CN204789331U - Optic fibre surface plasma resonance image sensor based on smart mobile phone monitoring platform - Google Patents
Optic fibre surface plasma resonance image sensor based on smart mobile phone monitoring platform Download PDFInfo
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- CN204789331U CN204789331U CN201520544872.4U CN201520544872U CN204789331U CN 204789331 U CN204789331 U CN 204789331U CN 201520544872 U CN201520544872 U CN 201520544872U CN 204789331 U CN204789331 U CN 204789331U
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Abstract
The utility model belongs to biochemical sensing field, optic fibre surface plasma resonance image sensor based on smart mobile phone monitoring platform. Utilize the resonant principle of surperficial plasma, in office more where, any time, through connecting an ordinary computer, just can carry out SPR's detection. Technical scheme is: utilize the LED light source to form monochromatic light, light has the optic fibre of flow -through cell through the package, and the optic fibre of flow -through cell position department can produce the SPR phenomenon through special treatment, and the effect of flow -through cell is convenient measuring to biochemical liquid, can the real -time measurement. Light through optic fibre is accepted by terminal camera, demonstrates the facula on the cell -phone screen. Through the programming, realize the measurement to facula intensity. This system of that is to say can become the information into of biochemical liquid the information of facula intensity, and anytime and anywhere that can convenient and fast carries on that SPR is biochemical to be detected. The utility model discloses a SPR is biochemical to be detected can carrying on at anytime and anywhere, simple swift, moreover low cost.
Description
Technical field
The utility model belongs to a kind of biochemical sensitive technical field, relates to the principle of surface plasma body resonant vibration (SPR).
Background technology
Surface plasma resonance (SurfacePlasmonResonance, SPR) sensor is a kind of novel photoelectric detecting technology, its crucial probe portion is a sensitizing range based on surface plasmon resonance effect, when incident light is when meeting certain condition, cause the resonance of metal free electron, thus make the reflected light of specific wavelength obviously weaken to realize sensing effect.Compared with traditional sensor, it has the advantages such as equipment is simple, highly sensitive, good stability, fast response time, be widely used at many key areas such as medical science, biology, environment, food inspection, pharmacy and move to maturity gradually, there is good development prospect.
At present, lens type spr sensor has had commercial finished product instrument abroad, and also can realize hyperchannel on-line checkingi, but due to its complex structure, bulky, be not suitable for portable type measuring etc., application is very restricted.The unique advantage such as itself small size, high flexibility and cost of optical fiber is low, becomes a kind of developing direction of portable sensor.Optical fiber SPR sensor, compared with glass prism SPR sensor, has highly sensitive, fast response time, and dynamic range is large, anti-electromagnetic interference (EMI), and superelevation insulate, and passivity, be suitable for real-time detection, volume is little, dirigibility advantages of higher.
But current optical fiber SPR sensor needs to use in the lab, no matter wavelength SPR, polarization SPR, angle SPR or image SPR needs the experiment equipments such as light source, (FBG) demodulator, CCD, cost is higher, and higher to requirement for experiment condition.
Utility model content
The technical problems to be solved in the utility model is to provide a kind of portable fiber-optic SPR imageing sensor, optical fiber element is used to substitute prism element, significantly simplify light path and control system, the LED flashlamp of use smart mobile phone and camera are as light source and detector, whole system structure is simple, with low cost, may be used for the quick detection carrying out biological sample.This sensor does not need large-scale experimental apparatus, is easy to carry.Damage can not be produced to sample, low to the requirement of working environment.This sensor can not only realize biochemistry detection, and adds reference channel, guarantees the accuracy of experimental result.
The technical scheme that the utility model adopts is: a kind of optical fiber surface plasmon resonance body imageing sensor based on smart mobile phone monitoring platform, and this optical fiber surface plasmon resonance body imageing sensor comprises two passes: test channel and reference channel; Test channel: the LED flashlamp on mobile phone by optical fiber and fiber sensing element, final Fiber connection camera; Reference channel is that the optical fiber be directly connected by LED flashlamp and camera is formed; Fiber sensing element forms closed-loop path by optical fiber and LED flashlamp and camera, light sends from LED flashlamp, successively by optical fiber and fiber sensing element, be caught on camera head from the injection of the fiber sensing element other end again to catch and synthetic image, enter the signal of optical fiber as Measurement channel of shooting head end, changed by the light intensity of mobile phone computed image, realize the detection to testing sample;
LED flashlamp is provided with lens and filter plate outward successively;
Described fiber sensing element is namely by the fiber area that flow cell wraps up, and fiber sensing element adopts optical fiber light-guiding kapillary, and after being removed 5-10mm covering by flow cell wrapping portion, the golden film of plating 45-55nm thickness is made;
Described fiber sensing element is wrapped up by flow cell, and flow cell has flow cell entrance and flow cell outlet, testing sample is flowed into by flow cell entrance, after flowing through fiber sensing element surface, then exports outflow by flow cell.
Effect of the present utility model and benefit can carry out SPR biochemistry detection whenever and wherever possible, simple and fast, and with low cost.
Accompanying drawing explanation
Accompanying drawing 1 is the optical fiber image sensor system schematic diagram based on smart mobile phone detection platform.
In figure: 1LED flashlamp; 2 lens; 3 filter plates; 4 optical fiber; 5 flow cell entrances; 6 flow cell outlets; 7 fiber sensing element; 8 flow cells; 9 reference channels; 10 Measurement channel; 11 cameras; 12 mobile phones.
Embodiment
Embodiment of the present utility model is described in detail below in conjunction with technical scheme and accompanying drawing.
1. instrument
(1) smart mobile phone, as Fig. 1.
(2) liquid communication ponds, as Fig. 1.
(3) optical fiber, material is the plastic optical fiber HPOF produced by Chang Fei company, Hewlett-Packard 400/430-37/730E.Length is 15 ㎝, and the diameter of fibre core and covering is respectively 400 μm and 430 μm of numerical apertures are 0.37, light-conducting capillaries SPR sensing element, the LTSP150/375 that material is produced by Mo Shi company of the U.S., length 4cm, inside and outside through being respectively 150 μm and 375 μm, numerical aperture 0.22.
2. apparatus and process
Utilize grinding technique to carry out microstructure process to the end face of light-conducting capillaries, two end faces are made into plane.Then remove the covering of 5mm in middle part, use coating machine to plate the golden film of 50nm, install flow cell in the position of plated film.Optical fiber two ends polish, as reference passage.Two import and export optical fiber, and wherein one end is aimed at LED, and the other end is aimed at camera, as Fig. 1.
3. operate
Proving installation as shown in Figure 1.Testing sample is con A.In implementation process, from the light of LED by entering into camera after optical fiber, mobile phone screen can detect two circular light spots.When passing into the liquid that refractive index becomes large successively in flow cell, SPR phenomenon can be there is in the region of the gold-plated film of optical fiber, along with the rising of liquid refractivity, can find that the other end light intensity of the optical fiber as Measurement channel strengthens gradually, and not have the fiber end face light intensity of plated film there is no marked change.By program, hot spot is processed, the relation of relative intensity (ratio of test channel and reference channel hot spot light intensity) and liquid refractivity can be obtained, thus complete the measurement of refractive index.Gray level image is converted to by the coloured image captured by camera.In gray level image, the brightness of each image represents with gray-scale value, and gray-scale value can change to 100% (black) from 0% (white).So the intensity of photo can be weighed by the gray-scale value sum of pixels all on picture.This system, for testing the solution of different refractivity, obtains good linear response curve, and due to the existence of reference channel, even if when light source there occurs larger fluctuation, still obtains ideal test result.In addition can carry out chemical modification as the optical fiber of test channel makes it have specific recognition function.
Claims (1)
1. based on an optical fiber surface plasmon resonance body imageing sensor for smart mobile phone monitoring platform, it is characterized in that, this optical fiber surface plasmon resonance body imageing sensor is made up of test channel and reference channel:
Test channel comprises smart mobile phone LED flashlamp, lens, filter plate, flow cell, fiber sensing element and camera, flow cell has flow cell entrance and flow cell outlet; Scioptics, filter plate is sent from smart mobile phone LED flashlamp, flow cell entrance is delivered to by optical fiber, exported by flow cell after fiber sensing element and flow out, be caught on camera head from the injection of the fiber sensing element other end to catch and synthetic image, enter the signal of optical fiber as Measurement channel of shooting head end, changed by the light intensity of mobile phone computed image, realize the detection to testing sample;
Reference channel comprises smart mobile phone LED flashlamp, lens, filter plate, optical fiber and camera; Send scioptics, filter plate from smart mobile phone LED flashlamp, after entering optical fiber, directly deliver to camera;
The fiber area that described fiber sensing element is wrapped up by flow cell, it adopts optical fiber light-guiding kapillary, after being removed 5-10mm covering by flow cell wrapping portion, the golden film of plating 45-55nm thickness.
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| CN201520544872.4U CN204789331U (en) | 2015-07-24 | 2015-07-24 | Optic fibre surface plasma resonance image sensor based on smart mobile phone monitoring platform |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105466808A (en) * | 2016-01-13 | 2016-04-06 | 中国计量学院 | Liquid refractive index optical fiber sensor based on image analysis and surface plasma resonance |
| CN106442418A (en) * | 2016-09-06 | 2017-02-22 | 大连理工大学 | Low-cost spectroscopic imaging system based on surface plasma resonance |
| KR101732875B1 (en) * | 2016-05-18 | 2017-05-08 | 경상대학교산학협력단 | Biosensor measuring device using a smartphone |
| CN108489940A (en) * | 2018-03-15 | 2018-09-04 | 温州生物材料与工程研究所 | Mobile phone biochemistry imaging device based on surface plasma body resonant vibration |
-
2015
- 2015-07-24 CN CN201520544872.4U patent/CN204789331U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105466808A (en) * | 2016-01-13 | 2016-04-06 | 中国计量学院 | Liquid refractive index optical fiber sensor based on image analysis and surface plasma resonance |
| CN105466808B (en) * | 2016-01-13 | 2018-08-03 | 中国计量学院 | A kind of liquid refractivity fibre optical sensor based on image analysis and surface plasma body resonant vibration |
| KR101732875B1 (en) * | 2016-05-18 | 2017-05-08 | 경상대학교산학협력단 | Biosensor measuring device using a smartphone |
| CN106442418A (en) * | 2016-09-06 | 2017-02-22 | 大连理工大学 | Low-cost spectroscopic imaging system based on surface plasma resonance |
| CN108489940A (en) * | 2018-03-15 | 2018-09-04 | 温州生物材料与工程研究所 | Mobile phone biochemistry imaging device based on surface plasma body resonant vibration |
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