CN204120992U - Three-dimensional optical molecular image navigation system - Google Patents
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- CN204120992U CN204120992U CN201420532142.8U CN201420532142U CN204120992U CN 204120992 U CN204120992 U CN 204120992U CN 201420532142 U CN201420532142 U CN 201420532142U CN 204120992 U CN204120992 U CN 204120992U
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Abstract
This utility model relates to a kind of three-dimensional optical molecular image navigation system.Described system comprises: system support module, light source module, optical signalling acquisition module, three-dimensional localization module and computer module; System support module supports the equipment in system; Light source module provides light source irradiation to imaging region; Optical signalling acquisition module gathers the optical signalling in imaging region; The depth information of three-dimensional localization module position probe device in imageable target; Computer module is to optimum configurations and carry out processing to view data and show.This utility model three-dimensional optical molecular image navigation system achieves the real time fusion imaging of optical fluorescence image and visible images to provide two dimensional navigation and to realize the continuous Dynamic Announce of 3 D anatomy structure image to provide three-dimensional navigation.
Description
Technical field
This utility model relates to optical molecular image technology field, particularly relates to a kind of three-dimensional optical molecular image navigation system.
Background technology
Molecular image is 21 century one of the most dazzling science and technology, and it refers to and detects molecule in organism on a molecular scale with no damage, and provides the Medical Imaging Technology of molecular distribution information in body.And be proved be a kind of can volume visualization molecule, gene, cellular level organism physiological and pathological change imaging tool.As wherein a kind of important molecular image image mode, optical molecular image relies on the advantage such as self low cost, high flux, non-intruding, noncontact, Non-ionizing radiation, highly sensitive, high specificity to be applied to the field such as the earlier detection of tumor, the research and development of medicine.
Optical molecular image technology is compared to traditional image technology, there is following advantage: one, process complicated to gene expression, bio signal transmission etc. can be become image intuitively by optical molecular image technology, makes people can understand the generation of disease, development mechanism and process better on a molecular scale; Its two, the molecular variant that disease is early stage and pathological change process can be found; Its three, can the mechanism of Continuous Observation medicine or gene therapy on live body and effect.Usually, the method chorista detection method of detection biological tissue molecule and body detection method two kinds, optical molecular image technology is as one at body detection method, and it is advantageous that can fast, at a distance, obtain the image of biological tissue's molecule with no damage.It can disclose the early molecule biological property of pathological changes, thus provides possibility, also for clinical diagnosis introduces new concept for the early diagnosis and therapy of disease.
Fluorescence excitation imaging technique is a kind of optical molecular image technology, the principle of fluorescence excitation imaging can be described as: by the excitation source of in vitro, fluorophor in irradiating biological body, it is made to reach higher-energy state, fluorophor absorbs luminous energy electron transition is arrived excited state, electronics is got back to the process of ground state can discharge fluorescence from excited state, this fluorescence comparatively exciting light moves to red end, the wavelength of the wavelength ratio fluorescence excitation of the fluorescence namely launched will be grown, fluorescence is propagated in organizer and some reaches body surface, the fluorescence sent from body surface is received by highly sensitive detector, thus formation fluoroscopic image.Usually, the fluorescence that fluorophor produces is after the absorption, scattering of organism inner tissue, when arriving surperficial, intensity is more weak, at this time, in the camera bellows environment that lucifuge condition is good, imaging operation is carried out with regard to needing, namely utilize highly sensitive CCD camera to catch the fluorescent photon arriving surface, the signal of then being caught by computer disposal also carries out imaging.
Optical molecular image navigation technology is exactly utilize a kind of technology of fluorescence excitation imaging technique for becoming experimental implementation person to provide navigation, the real time fusion imaging of fluoroscopic image and visible images, can guide imaging experiment operator to obtain the two-dimensional position information of fluorescence area.Dynamic 3 D anatomy structure data imaging can provide depth information for experimental implementation person continuously.Thus, three-dimensional optical molecular image navigation system can provide the image of two dimension to guide and the image of three-dimensional guides, and has good assosting effect for carrying out experimental implementation.
The optical molecular image-guidance system of current existing molding mainly provides the guiding of the image information of two dimension, adopt the continuous dynamic imaging of fluoroscopic image or adopt the continuous dynamic imaging of the fusion image of fluoroscopic image and visible images to provide navigation for imaging experiment operator, and three-dimensional optical molecular image navigation system is while providing real time fusion imaging, the 3-D view of picture target anatomical structure information can also be provided as.
Utility model content
The purpose of this utility model is the defect for prior art, a kind of three-dimensional optical molecular image navigation system is provided, to realize the real time fusion imaging of optical fluorescence image and visible images to provide two dimensional navigation, and realize the continuous Dynamic Announce of 3 D anatomy structure image to provide three-dimensional navigation.
For achieving the above object, this utility model provides a kind of three-dimensional optical molecular image navigation system, and described system comprises: system support module (101), light source module (107), optical signalling acquisition module (114), three-dimensional localization module (122) and computer module (125);
System support module (101) supports the equipment in system;
Light source module (107) provides light source irradiation to imaging region;
Optical signalling acquisition module (114) gathers the optical signalling in imaging region;
The depth information of three-dimensional localization module (122) position probe device in imageable target;
Computer module (125) is to optimum configurations and carry out processing to view data and show;
Described system support module (101) is connected with light source module (107) by light source bracket (102); System support module (101) is connected with optical signalling acquisition module (114) by optical table support (106); System support module (101) is connected with three locating modules (122) by three positioner supports (100); System support module (101) is connected with computer module (125) with computer display support (104) by main frame support (103).
This utility model three-dimensional optical molecular image navigation system, according to the feature of fluorescence excitation Real Time Imaging Technology and the data characteristics of 3 D anatomy structure image, and based on the long-term research experience in fluorescence excitation technical field of imaging, provide three-dimensional optical molecular image navigation system, adopt two CCD camera, an excitation source, a white light source, a synchronizer trigger, the devices such as a positioner realize the real time fusion imaging of optical fluorescence image and visible images to provide two dimensional navigation and to realize the continuous Dynamic Announce of 3 D anatomy structure image to provide three-dimensional navigation.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of this utility model three-dimensional optical molecular image navigation system;
Fig. 2 is the air navigation aid flow chart of this utility model three-dimensional optical molecular image navigation system.
Detailed description of the invention
Below by drawings and Examples, the technical solution of the utility model is described in further detail.
The content that this utility model three-dimensional optical molecular image navigation system relates to comprises computer digital image processing method, fluorescence excitation image realtime imaging method, visible images realtime imaging method, fluorescence excitation and visible images real time fusion formation method, 3 D anatomy structure cross section information realtime imaging method.
This utility model three-dimensional optical molecular image navigation system is according to the data characteristics of the feature of fluorescence excitation Real Time Imaging Technology and 3 D anatomy structure image, and based on the long-term research experience in fluorescence excitation technical field of imaging, provide three-dimensional optical molecular image navigation system, adopt two CCD camera, an excitation source, a white light source, a synchronizer trigger, the devices such as a positioner realize the real time fusion imaging of optical fluorescence image and visible images to provide two dimensional navigation and to realize the continuous Dynamic Announce of 3 D anatomy structure image to provide three-dimensional navigation.
Fig. 1 is the schematic diagram of this utility model three-dimensional optical molecular image navigation system, and as shown in the figure, native system specifically comprises: system support module 101, light source module 107, optical signalling acquisition module 114, three-dimensional localization module 122 and computer module 125.
System support module 101 is connected with light source module 107 by light source bracket 102; System support module 101 is connected with optical signalling acquisition module 114 by optical table support 106; System support module 101 is connected with three locating modules 122 by three positioner supports 100; System support module 101 is connected with computer module 125 with computer display support 104 by main frame support 103.
System support module 101 is for providing a supporting role the equipment used in system; Light source module 107 is for providing light source irradiation to imaging region; Optical signalling acquisition module 114 is for gathering the optical signalling in imaging region; Three-dimensional localization module 122 is for the depth information of position probe device in imageable target.Computer module 125 is for carrying out necessary optimum configurations and carrying out processing to view data and show to this system.
System support module 101 comprises three positioner supports 100, light source bracket 102, main frame support 103, computer display support 104, system frame 105, optical table support 106.Wherein: three positioner supports 100 support three locating modules 122.Light source bracket 102 is for supporting light sources module 107.Main frame support 103 is for supporting main frame.Computer display support 104 is for supporting computer display.System frame 105 is for supporting 3 D locating device support 100, light source bracket 102, main frame support 104, computer display support 105 and optical table support 106.Optical table support 106 is for support of optical signal acquisition module 114; Three positioner supports 102 are connected with system frame 105; Light source bracket 102 is connected with system frame 105; Main frame support 103 is connected with system frame 105; Computer display support 104 is connected with system frame 105; Optical table support 106 is connected with system frame 105.
Light source module 107 comprises fluorescence excitation light source 108, white light source 109, first optical filter 110, second optical filter 111.Wherein: fluorescence excitation light source 108, for providing fluorescence excitation; First optical filter 111, is built in fluorescence excitation light source 108, and the fluorescence excitation that fluorescence excitation light source 108 provides is by being irradiated to imaging region 112 after the first optical filter 110.Visible light source 109, for providing visible ray; Second optical filter 111, is built in visible light source 109, and the visible ray 109 that visible light source provides is by being irradiated to imaging region 112 after the second optical filter 111.
Optical signalling acquisition module 114 comprises optical lens 115, Amici prism 116, the 3rd optical filter the 117, four optical filter 118, CCD Visible Light Camera 119, CCD fluorescence camera 121, synchronous triggering device 121.Wherein: optical lens 116 is connected with Amici prism 116; 3rd optical filter 117 is positioned at the seam of Amici prism 116 and CCD fluorescence camera 120; 4th optical filter 118 is positioned at the seam of Amici prism 116 and CCD Visible Light Camera 119; CCD Visible Light Camera is connected with Amici prism, for gathering the visible ray in imaging region 112; CCD fluorescence camera 120 is connected with Amici prism, for gathering the fluorescence excitation in imaging region 112, synchronous triggering device is connected with CCD fluorescence camera 120, CCD Visible Light Camera 119 and main frame, for synchronously triggering CCD fluorescence camera 120 and CCD Visible Light Camera 121 obtains fluoroscopic image and visible images.
Three-dimensional localization module 122 comprises probe unit 123, positioner 124.Wherein: positioner 124 is connected with system support module 101 by 3 D locating device support 100; Probe unit 123 can move to all directions at imaging region 122.Probe unit 113 is for the anatomical structure cross section information in detection imaging target 113.Positioner 124 is for the position of position probe device 123 in imageable target 113.When probe unit 113 inserts in imageable target 113, positioner can the particular location of needle point of position probe device 123, and calculates the degree of depth that probe tip is positioned at imageable target 113.
Computer module 125 comprises software control module 126, data memory module 127, data processing module 128, data disaply moudle 129.Wherein: software control module 126 is for arranging some basic parameters in three-dimensional localization module 122, optical signalling acquisition module 114, light source module 107.The imageable target 113 anatomical structure three-dimensional data information of data memory module 127 for collecting before storing imaging experiment, and the optical data that in imaging experiment, optical signalling acquisition module 114 collects.Data processing module 128 is according to the positional information returned in three-dimensional localization module 122, extract the cross-section data information of the anatomical structure data at the imageable target 113 interior location place, needle point place of probe unit 123, and be presented on data disaply moudle 129, can simultaneously continuously Dynamic Announce X-Y plane, X-Z plane, the cross section information of Y-Z plane and the three-dimensional image information of 3 D anatomy structure data.Simultaneously, the process such as the fluoroscopic image data that optical signalling acquisition module collects by data processing module 128 and the adjustment of visible images data luminance, feature extraction, feature enhancing, coupling, fusion, obtain the fusion image of fluoroscopic image and visible images, and be dynamically presented on data disaply moudle 129 continuously.Data disaply moudle 129 is mainly used in video data processing module 128 by the object information after date processing.Software control module 126 is connected with data memory module 127; Software control module 126 is connected with data processing module 128; Software control module 126 is connected with data disaply moudle 129; Data memory module 127 is connected with data processing module 128; Data processing module 128 is connected with data disaply moudle 129.
Fig. 2 is the air navigation aid flow chart of this utility model three-dimensional optical molecular image navigation system, as shown in the figure, the system shown in composition graphs 1, this method specifically comprises:
Step S1: system frame 102 and optical table support 106 are adjusted to suitable height by system support module 101.Open main frame 301, computer display 302, positioner 124, synchronous triggering device 121, CCD fluorescence camera 120, CCD Visible Light Camera 119, fluorescence excitation light source 108, visible light source 109 pairs of imaging regions 112 irradiate.
Step S2: open the software control module 126 in computer module 125, data memory module 127, data processing module 128, data disaply moudle 129, the synchronous trigger rate of synchronous triggering device 121 is set in software control module 126, CCD fluorescence camera 120 and CCD Visible Light Camera 119 camera exposure time, camera shutter mode, whether autostore view data, the parameters such as the positional parameter of positioner, then control both optical signal acquisition module 114 and three-dimensional localization module 122, optical signalling acquisition module 114 pairs of imaging regions 112 are made to carry out data acquisition, positioner 122 pairs of probe units 123 of three-dimensional localization module are made to carry out location positioning.
Step S3: according to the synchronous trigger rate arranged in software control module 126, synchronous triggering device 121 can the synchronous CCD of triggering fluorescence camera 120 and the synchronous view data obtained in imaging region 122 of CCD Visible Light Camera 119.
Positioner 124 pairs of probe units 123 simultaneously in three-dimensional localization module 122 carry out location positioning, the position of position probe device in imageable target 113.
Step S4:CCD fluorescence camera 120 and CCD Visible Light Camera 119 by the view data that captures by data line transfer to computer module 125, data processing module 128 in computer module 125 processes the view data transmitted, the fluoroscopic image data capture CCD fluorescence camera 120 and CCD Visible Light Camera 119 and visible images data carry out brightness adjustment, feature extraction, feature strengthens, add pseudo-colours, coupling, the process such as fusion, and the view data after merging is presented in data disaply moudle 129, be stored in needing the data stored in data memory module 127.
Simultaneously, according to the positional information of the position probe device 123 that three-dimensional localization module transmits, cross section information corresponding for the anatomical information of the imageable target 113 obtained before the experiment in data memory module 127 is extracted, and be presented in data disaply moudle 129, meanwhile, also by the 3 D anatomy structure information displaying of imageable target 113 in data disaply moudle 129.
Step S5: in data disaply moudle 129, has some rendering preferences, such as: display fusion image data, display fluoroscopic image data, and display White-light image data, display 3 D anatomy structure view data, interface data of display imageable target 113 etc.User also can select corresponding option as required in data disaply moudle 129.
Can find out according to above scheme, this utility model has following beneficial effect:
1. utilize this utility model, can only by the fluoroscopic image realizing just can continuously, dynamically obtaining in imaging region 112 and White-light image, and the fluoroscopic image data and White-light image data that utilize computer module to merge to collect, and do real time fusion display, efficiently solve continuously, dynamically show this problem of fusion image.
2. utilize this utility model, can control both optical signal acquisition module 114 and three-dimensional localization module 122 easily by the software control module 126 in computer module 125, making optical signalling acquisition module 114 gather fluoroscopic image data and White-light image data, is three-dimensional localization module positioning position information., effectively processed by data processing module 128 pairs of data meanwhile, make the clear picture that finally obtains and feature is given prominence to.Function is remarkable, simple and convenient.
3. utilize this utility model, by the convenient design of support, can the operation such as easy of rise, movement.Meanwhile, by selecting rational optical filter and suitable fluorescence intensity, darker fluorescence information can be detected, the optical signalling that can farthest remain with.
4. pass through this utility model, owing to needing to carry out lucifuge process in experimentation, simultaneously, by placing the first optical filter 110 and place 2 optical filters 111 in fluorescence excitation light source 108 in visible light source 109, make to be irradiated to fluorescence signal on imaging region 112 and visible light signal has different spectral regions, in practical operation, experimenter can see white light information clearly, also can observe obvious fluorescence information simultaneously, and both fuse informations.
5. pass through this utility model, by the positioner 124 in three-dimensional localization module 122, can the position of position probe device 123 in imageable target 113, simultaneously by the anatomical information of the imageable target of storage in computer module 125, can extract and show the anatomical structure cross section information of the imageable target 113 of the position in probe unit 123 needle point place imageable target 113, also can show the anatomical structure three-dimensional data information of imageable target.
Above-described detailed description of the invention; the purpose of this utility model, technical scheme and beneficial effect are further described; be understood that; the foregoing is only detailed description of the invention of the present utility model; and be not used in restriction protection domain of the present utility model; all within spirit of the present utility model and principle, any amendment made, equivalent replacement, improvement etc., all should be included within protection domain of the present utility model.
Claims (6)
1. a three-dimensional optical molecular image navigation system, it is characterized in that, described system comprises: system support module (101), light source module (107), optical signalling acquisition module (114), three-dimensional localization module (122) and computer module (125);
System support module (101) supports the equipment in system;
Light source module (107) provides light source irradiation to imaging region;
Optical signalling acquisition module (114) gathers the optical signalling in imaging region;
The depth information of three-dimensional localization module (122) position probe device in imageable target;
Computer module (125) is to optimum configurations and carry out processing to view data and show;
Described system support module (101) is connected with light source module (107) by light source bracket (102); System support module (101) is connected with optical signalling acquisition module (114) by optical table support (106); System support module (101) is connected with three locating modules (122) by three positioner supports (100); System support module (101) is connected with computer module (125) with computer display support (104) by main frame support (103).
2. system according to claim 1, it is characterized in that, described system support module (101) comprises three positioner supports (100), light source bracket (102), main frame support (103), computer display support (104), system frame (105), optical table support (106), wherein:
Described three positioner supports (100) support three locating modules (122);
Described light source bracket (102) supports described light source module (107);
Described main frame support (103) supports main frame;
Described computer display support (104) supports computer display; Described system frame (105) supports described 3 D locating device support (100), light source bracket (102), main frame support (104), computer display support (105) and optical table support (106);
Described optical table support (106) is for supporting described optical signalling acquisition module (114);
Described three positioner supports (122) are connected with system frame (105); Light source bracket (102) is connected with system frame (105); Main frame support (103) is connected with system frame (105); Computer display support (104) is connected with system frame (105); Optical table support (106) is connected with system frame (105).
3. system according to claim 1, it is characterized in that, described light source module (107) comprises fluorescence excitation light source (108), white light source (109), the first optical filter (110), the second optical filter (111); Wherein:
Described fluorescence excitation light source (108) provides fluorescence excitation; Described first optical filter (110) is built in described fluorescence excitation light source (108), and the fluorescence excitation that described fluorescence excitation light source (108) provides is by being irradiated to described imaging region (112) after described first optical filter (110);
Described visible light source (109) provides visible ray; Described second optical filter (111), be built in described visible light source (109), the visible ray (109) that described visible light source provides is by being irradiated to described imaging region (112) after described second optical filter (111).
4. system according to claim 1, it is characterized in that, described optical signalling acquisition module (114) comprises optical lens (115), Amici prism (116), the 3rd optical filter (117), 4th optical filter (118), CCD Visible Light Camera (119), CCD fluorescence camera (121), synchronous triggering device (121); Wherein:
Described optical lens (115) is connected with described Amici prism (116); Described 3rd optical filter (117) is positioned at the seam of described Amici prism (116) and described CCD fluorescence camera (120); Described 4th optical filter (118) is positioned at the seam of described Amici prism (116) and described CCD Visible Light Camera (119); Described CCD Visible Light Camera (119) is connected with described Amici prism (116), gathers the visible ray in imaging region (112); Described CCD fluorescence camera (120) is connected with described Amici prism (116), gather the fluorescence excitation in described imaging region (112), synchronous triggering device (121) is connected with described CCD fluorescence camera (120), CCD Visible Light Camera (119) and main frame, obtains fluoroscopic image and visible images for synchronously triggering described CCD fluorescence camera (120) and CCD Visible Light Camera (121).
5. system according to claim 1, is characterized in that, described three-dimensional localization module (122) comprises probe unit (123), positioner (124); Wherein:
Described probe unit (113) detects the anatomical structure cross section information in described imageable target (113); The position of described probe unit (123) in described imageable target (113) located by described positioner (124);
Described positioner (124) is connected with system support module (101) by 3 D locating device support (100); Probe unit (123) moves to all directions at imaging region (122);
When described probe unit (113) inserts in described imageable target (113), the position of the needle point of described probe unit (123) located by described positioner (124), and calculates the degree of depth that needle point is positioned at described imageable target (113).
6. system according to claim 1, it is characterized in that, described computer module (125) comprises software control module (126), data memory module (127), data processing module (128), data disaply moudle (129); Wherein:
Described software control module (126) arranges the basic parameter in described three-dimensional localization module (122), optical signalling acquisition module (114), light source module (107);
Imageable target (113) the anatomical structure three-dimensional data information that described data memory module (127) storage of collected arrives, and the optical data that described optical signalling acquisition module (114) collects;
Described data processing module (128) is according to the positional information returned in three-dimensional localization module (122), the cross-section data information of the anatomical structure data at imageable target (113) interior location place described in the needle point place extracting probe unit (123), and be presented on described data disaply moudle (129), Dynamic Announce (X-Y) plane, (X-Z) plane, the cross section information of (Y-Z) plane and the three-dimensional image information of 3 D anatomy structure data;
The fluoroscopic image data that described optical signalling acquisition module (114) collects by described data processing module (128) and the adjustment of visible images data luminance, feature extraction, feature strengthen, coupling, fusion treatment, obtain the fusion image of fluoroscopic image and visible images, to be dynamically presented at described in number according to the show in module (129);
Described data disaply moudle (129) show described data processing module (128) carry out date processing after object information;
Described software control module (126) is connected with data memory module (127); Software control module (126) is connected with data processing module (128); Software control module (126) is connected with data disaply moudle (129); Data memory module (127) is connected with data processing module (128); Data processing module (128) is connected with data disaply moudle (129).
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188628A (en) * | 2014-09-16 | 2014-12-10 | 中国科学院自动化研究所 | Three-dimensional optical molecular image navigation system and three-dimensional optical molecular image navigation method |
| CN115393348A (en) * | 2022-10-25 | 2022-11-25 | 绵阳富临医院有限公司 | Burn detection method and system based on image recognition and storage medium |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104188628A (en) * | 2014-09-16 | 2014-12-10 | 中国科学院自动化研究所 | Three-dimensional optical molecular image navigation system and three-dimensional optical molecular image navigation method |
| WO2016041155A1 (en) * | 2014-09-16 | 2016-03-24 | 中国科学院自动化研究所 | Three-dimensional optical molecular image navigation system and method |
| CN115393348A (en) * | 2022-10-25 | 2022-11-25 | 绵阳富临医院有限公司 | Burn detection method and system based on image recognition and storage medium |
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