CN203724101U - Biosensor - Google Patents
Biosensor Download PDFInfo
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- CN203724101U CN203724101U CN201420051257.5U CN201420051257U CN203724101U CN 203724101 U CN203724101 U CN 203724101U CN 201420051257 U CN201420051257 U CN 201420051257U CN 203724101 U CN203724101 U CN 203724101U
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- Prior art keywords
- basic unit
- sap cavity
- biosensor
- upper strata
- notch
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Abstract
The utility model discloses a biosensor which comprises a sensor body and an electrode located inside the sensor body. The two ends of the sensor body are the collecting end and the electric contact end respectively, a liquid cavity serving as a liquid sample chamber is formed inside the collecting end, the two sides and the front side of the collecting end are respectively communicated with the liquid cavity, and a groove hole communicated with the liquid cavity is formed in the bottom face of the collecting end. According to the biosensor, a liquid sample inlet of the liquid cavity is designed to be an ultra-wide sampling inlet; when liquid samples are sucked into the liquid cavity, the liquid sample inlet can be easily aligned with the liquid samples small in size, a small number of samples scattered on the surface of the skin can be easily sucked, the blocking problem of the opening end is solved, and the problem that inaccurate testing results are possibly caused by the fact that when detection is carried out, the liquid sample chamber is not completely filled by the samples, and sucking is discontinuous is solved.
Description
Technical field
This utility model relates to biosensor technique field, particularly a kind of biosensor.
Background technology
In the time diagnosing some physically different, be very important to the Accurate Determining of some analyte in body fluid, particularly, diabetics needs their blood sugar level of running check, to regulate the intake of daily glucose, determine the consumption of insulin or using of other drug.In blood sugar test system, testing sensor, or be called glucose examination bar and hand-held blood glucose meter is being used by millions of diabeticss every day all over the world.
At present, on market, there are blood glucose meter and the examination bar of hundreds of brands.Wherein, disposable electrochemica biological sensor (or being called examination bar), is called for short biosensor, is widely known by the people, and is used to test the concentration of various body fluid (as analyte in blood).With regard to examination bar, their structure is very similar, all has sap cavity, and fluid sample is because capillarity enters from the opening of sap cavity, and the air in sap cavity is discharged from the steam vent of the other end.
Taking blood specimen collection as example, be to reduce the volume of sample, be also the pain in order to reduce sampling simultaneously, sap cavity is conventionally less, so since, the entrance of sap cavity also does very littlely.But the result of said structure setting is that sample is difficult to enter sap cavity or is difficult to be full of sap cavity.Observe clinically: user's finger usually can block entrance, cause sample introduction not smooth, make sample can not once be full of sap cavity; Some diabetes patient has defective vision, and the entrance of sap cavity even can not be found or aim to finger tremor; Also in some cases, blood usually can not form and drip shape at finger tip, but scatters along finger, and this has just more increased the difficulty of sample introduction.These problems can cause test result inaccurate clinically, affect diabetes patient's diagnosis and treatment, and for a paradiabetes people, test result inaccurate, directly causes the dosage of insulin not right, when serious, can cause patients ' lives danger.
Therefore, how reducing or eliminating the measurement error that user causes due to sampling difficulty in the time using biosensor, is those skilled in the art's technical problems urgently to be resolved hurrily.
Utility model content
In view of this, this utility model provides a kind of biosensor, by sampling end is designed, make sample inlet have multi-faceted opening, can reach and reduce or eliminate user causes measurement error in the time using biosensor object due to sampling difficulty.
For achieving the above object, this utility model provides following technical scheme:
A kind of biosensor, comprise sensor body and the electrode that is positioned at described sensor body inside, the two ends of described sensor body are respectively collection terminal and electrically contact end, described collection terminal inside is provided with the sap cavity as fluid sample chamber, the both sides of described collection terminal and front side communicate with described sap cavity respectively, and the bottom surface of described collection terminal is provided with the slotted eye communicating with described sap cavity.
Preferably, in above-mentioned biosensor, described sensor body comprises the first basic unit, the second basic unit, the first upper strata and second upper strata of stack successively, wherein:
The upper surface of described the first basic unit is provided with described electrode;
The part that described the second basic unit is positioned at described collection terminal is provided with the through hole of answering with described electrode pair;
The end that described the first upper strata is positioned at described collection terminal is provided with sap cavity notch, and part corresponding with described sap cavity notch in described the second upper strata and described the second basic unit forms described sap cavity with described sap cavity notch.
Preferably, in above-mentioned biosensor, the leading flank of described the first basic unit is provided with the first notch;
The leading flank of described the second basic unit is provided with the second notch;
The leading flank of described the first basic unit aligns with the leading flank of described the second basic unit, and described the first notch and described the second notch position correspondence are to form described slotted eye.
Preferably, in above-mentioned biosensor, described electrode comprises at least one reference electrode and at least one working electrode.
Preferably, in above-mentioned biosensor, each described electrode is all connected with described slotted eye.
Preferably, in above-mentioned biosensor, the described through hole in described the second basic unit is corresponding one by one with described electrode.
Preferably, in above-mentioned biosensor, the leading flank on described the first upper strata is positioned at the upper surface upside of described the second basic unit, and keeps the first predeterminable range with the leading flank of described the second basic unit;
The leading flank on described the second upper strata is positioned at the upper surface upside of described the second basic unit, and keeps the second predeterminable range with the leading flank of described the second basic unit, and described the first predeterminable range is greater than described the second predeterminable range.
Preferably, in above-mentioned biosensor, described sap cavity notch is arc-shaped slot.
Preferably, in above-mentioned biosensor, the part that described the second upper strata is positioned at described collection terminal is provided with the steam vent communicating with described sap cavity.
Preferably, in above-mentioned biosensor, described steam vent has multiple, and arranges successively along the bottom land of described arc-shaped slot.
Can find out from technique scheme, what this utility model was carried supplies biosensor, designs by the sampling end to sap cavity, makes sap cavity have a kind of super wide sampling entrance.When fluid sample is inhaled in sap cavity due to capillarity, the feed liquor direction that this entrance has multiple orientation such as comprising front side, left side, right side and bottom side (also comprising further top side) attracts in sap cavity.Especially the slotted eye that the bottom surface of collection terminal arranges, can allow blood sample to enter sap cavity by the bottom of biosensor, and this feature is even more important for the blood sample scattering at sample point.Thereby, above-mentioned biosensor is in the time sucking sap cavity by fluid sample, be easier to aim at the sample of small volume, be easy to suck a small amount of sample that skin surface scatters, and eliminated the blockage problem of opening, and reduced the indoor sample of fluid sample while detection full not exclusively, suck and discontinuous etc. may cause the inaccurate problem of test result.
Brief description of the drawings
In order to be illustrated more clearly in this utility model embodiment or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only embodiment more of the present utility model, for those of ordinary skill in the art, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
The overall structure schematic diagram of the biosensor that Fig. 1 provides for this utility model the first specific embodiment;
The overall structure schematic diagram of the biosensor that Fig. 2 provides for this utility model the second specific embodiment;
The side view of the biosensor that Fig. 3 provides for this utility model the first specific embodiment;
The side view of the biosensor that Fig. 4 provides for this utility model the second specific embodiment;
The decomposition texture schematic diagram of the biosensor that Fig. 5 provides for this utility model the first specific embodiment;
The top view of the biosensor that Fig. 6 provides for this utility model the first specific embodiment;
The structural representation of the first basic unit that Fig. 7 provides for this utility model the first specific embodiment;
The structural representation of the second basic unit that Fig. 8 provides for this utility model the first specific embodiment;
The structural representation on the first upper strata that Fig. 9 provides for this utility model the first specific embodiment;
The structural representation on the second upper strata that is provided with steam vent that Figure 10 provides for this utility model;
The structural representation on the second upper strata that steam vent is not set that Figure 11 provides for this utility model;
When the biosensor that Figure 12 provides for this utility model the first specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from front side;
When the biosensor that Figure 13 provides for this utility model the first specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from both sides;
When the biosensor that Figure 14 provides for this utility model the first specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from bottom side;
When the biosensor that Figure 15 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from top side;
When the biosensor that Figure 16 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from front side;
When the biosensor that Figure 17 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from both sides;
When the biosensor that Figure 18 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from bottom side.
Wherein, 10 for electrically contacting end, and 20 is sampling end, and 11 is the first working electrode, 12 is reference electrode, and 13 is the second working electrode, and 31 is the first through hole, and 32 is the second through hole, 33 is third through-hole, and 34 is slotted eye, and 41 is sap cavity notch, 44 is the first notch, and 54 is the second notch, and 74 is steam vent, 91 is side import, and 100 is sensor body, and 200 is the first basic unit, 300 is the second basic unit, and 400 is the first upper strata, and 500 is the second upper strata.
Detailed description of the invention
The utility model discloses a kind of biosensor, by sampling end is designed, make sample inlet have multi-faceted opening, can reach and reduce or eliminate user causes measurement error in the time using biosensor object due to sampling difficulty.
Below in conjunction with the accompanying drawing in this utility model embodiment, the technical scheme in this utility model embodiment is clearly and completely described, obviously, described embodiment is only this utility model part embodiment, instead of whole embodiment.Based on the embodiment in this utility model, those of ordinary skill in the art are not making the every other embodiment obtaining under creative work prerequisite, all belong to the scope of this utility model protection.
Refer to Fig. 1-Figure 18, the overall structure schematic diagram of the biosensor that Fig. 1 provides for this utility model the first specific embodiment, the overall structure schematic diagram of the biosensor that Fig. 2 provides for this utility model the second specific embodiment, the side view of the biosensor that Fig. 3 provides for this utility model the first specific embodiment, the side view of the biosensor that Fig. 4 provides for this utility model the second specific embodiment, the decomposition texture schematic diagram of the biosensor that Fig. 5 provides for this utility model the first specific embodiment, the top view of the biosensor that Fig. 6 provides for this utility model the first specific embodiment, the structural representation of the first basic unit that Fig. 7 provides for this utility model the first specific embodiment, the structural representation of the second basic unit that Fig. 8 provides for this utility model the first specific embodiment, the structural representation on the first upper strata that Fig. 9 provides for this utility model the first specific embodiment, the structural representation on the second upper strata that is provided with steam vent that Figure 10 provides for this utility model, the structural representation on the second upper strata that steam vent is not set that Figure 11 provides for this utility model, when the biosensor that Figure 12 provides for this utility model the first specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from front side, when the biosensor that Figure 13 provides for this utility model the first specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from both sides, when the biosensor that Figure 14 provides for this utility model the first specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from bottom side, when the biosensor that Figure 15 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from top side, when the biosensor that Figure 16 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from front side, when the biosensor that Figure 17 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from both sides, when the biosensor that Figure 18 provides for this utility model the second specific embodiment is worked, blood sample enters the work schematic diagram of sap cavity from bottom side.
The biosensor (for example disposable electrochemical sensor) that this utility model provides, for measuring the concentration of analyte of liquid biological sample.In the first specific embodiment, this biosensor comprises sensor body 100 and the electrode that is positioned at sensor body 100 inside, and the two ends of sensor body 100 are respectively collection terminal 20 and electrically contact end 10.Wherein, collection terminal 20 is for receiving fluid sample, the inside of collection terminal 20 is provided with the sap cavity as fluid sample chamber, the both sides of collection terminal 20 and front side (" front side " is the end face that sensor body 100 is positioned at collection terminal 20) communicate with sap cavity respectively, and the bottom surface of collection terminal 20 is provided with the slotted eye 34 communicating with sap cavity.
The biosensor visible, this utility model provides, designs by the sample inlet to sap cavity, makes sap cavity have a kind of super wide sampling entrance.When fluid sample is inhaled in sap cavity due to capillarity, this entrance has the feed liquor direction in multiple orientation such as comprising front side, left side, right side and bottom side, can easily fluid sample be attracted in sap cavity.Especially the slotted eye 34 that the bottom surface of collection terminal 20 arranges, can allow blood sample to enter sap cavity by the bottom of biosensor, and this feature is even more important for the blood sample scattering at sample point.Thereby, above-mentioned biosensor is in the time sucking sap cavity by fluid sample, be easier to aim at the sample of small volume, be easy to suck a small amount of sample that skin surface scatters, and eliminated the blockage problem of opening, and reduced the indoor sample of fluid sample while detection full not exclusively, suck and discontinuous etc. may cause the inaccurate problem of test result.
Particularly, electrically contacting in above-mentioned biosensor holds 10 for being connected with testing equipment, and preferably testing equipment is hand-held instrument.The analyte that can measure comprises glucose, lactic acid, uric acid, beta-hydroxybutyric acid, kreatinin, creatine, cholesterol, triglyceride, hemoglobin, bilirubin, ethanol etc.; The fluid sample that can measure can whole blood sample, blood serum sample, plasma sample, or other body fluid such as tear, interstitial fluid, urine.But be not limited to this, the biosensor application that those skilled in the art can also provide this utility model is in the test of other any fluid sample, this utility model is to this and be not specifically limited.
Refer to Fig. 5, in order further to optimize technique scheme, sensor body 100 comprises the multi-layer insulation layer of stack successively, is followed successively by from bottom to up the first basic unit 200, the second basic unit 300, the first upper strata 400 and the second upper strata 500.Wherein: the upper surface of the first basic unit 200 is provided with electrode (being conductive coating), the electric contact points that is used as working electrode, reference electrode and is connected with test instrumentation; The part that the second basic unit 300 is positioned at collection terminal 20 is provided with the through hole of answering with electrode pair, so that a part for conductive coating is come out, for limiting electrode area and load chemical reagent; The top that the first upper strata 400 is positioned at collection terminal 20 is provided with part corresponding with sap cavity notch 41 in sap cavity notch 41, the second upper stratas 500 and the second basic unit 300 and forms sap cavity (as shown in Figure 1 and Figure 5) with sap cavity notch 41.
Particularly, in above-mentioned biosensor, between multi-layer insulation layer, fit together by binding agent or other modes.Leading flank that it should be noted that the first basic unit 200, the second basic unit 300 and the second upper strata 500 aligns respectively, and the leading flank on the first upper strata 400 is clipped between the second basic unit 300 and the second upper strata 500.In other words, the front end (i.e. the end corresponding with sampling end 20) on the first upper strata 400 is positioned on the upper surface of the second basic unit 300, and keep certain distance with the leading flank of the second basic unit 300, to make the both sides of sampling end 20 there is the sample delivery point (referring to the side import 91 shown in Fig. 3) of multi-faceted injection port.Thus, formed sap cavity or the thin layer pond for contain fluid sample at the sampling end 20 of biosensor by the upper surface of the second basic unit 300 and the lower surface on the first upper strata 400.Wherein, the length of side import 91 is preferably from 0.01 millimeter to 2.5mm, and preferably from 0.1 to 0.3 millimeter, more preferably about 0.25 millimeter.
And, in above-mentioned biosensor, the leading flank of the first basic unit 200 is provided with the first notch 44, the leading flank of the second basic unit 300 is provided with second its position of notch 54(, shape is consistent with the first notch 44 with size), the leading flank of the first basic unit 200 aligns with the leading flank of the second basic unit 300, the first notch 44 and the second notch 54 position correspondences are to form slotted eye 34, and slotted eye 34 is for being positioned at a sample delivery point of front side in multi-faceted injection port.Although only demonstrate a slotted eye 34 at sampling end middle part in Fig. 1, can also some identical slotted eyes be set along the front end face of sampling end 20 in other embodiments, multiple slotted eyes may form as zigzag thief hatch front end.Further, the shape of slotted eye 34 can be but be not limited to circular arc, square, rectangle, triangle, trapezoid, inverted trapezoidal.Preferred embodiment is that slotted eye 34 is semicircular notch, is located at the centre of sampling end 20, and the diameter of semicircular notch is 0.1 to 2mm, and more preferably, diameter is in 1mm left and right.
In addition,, in above-mentioned biosensor, preferably make the second upper strata 500 there is identical width and length with the second basic unit 300.And the tail end on the tail end of the second basic unit 300, the tail end on the first upper strata 400 and the second upper strata 500 is in alignment with each other, is positioned on the upper surface of the first basic unit 200, and keeps certain distance with the trailing flank of the first basic unit 200.And the conductive surface (electrode) that the first basic unit 200 exposes is for being connected with test instrumentation, hold 10 to form electrically contacting of biosensor.Need to further illustrate, above " leading flank " of each insulation material layer all refers to the end face that is positioned at collection terminal 20.
Refer to Fig. 1, Fig. 9 and Figure 10, in a preferred embodiment, the sap cavity notch 41 that the end on the first upper strata 400 arranges is arc-shaped slot (being preferably semicircular notch), the part that the second upper strata 500 is positioned at collection terminal 20 is provided with the steam vent 74 communicating with sap cavity, this steam vent 74 has multiple (for example five), and the bottom land along arc-shaped slot is arranged successively, thereby effectively avoid fluid sample to overflow from steam vent.Preferably, steam vent 74 is circular port, and its diameter is less than 0.5mm, is preferably about 0.1 millimeter.But be not limited to this, due to the unique design of above-mentioned super wide sampling entrance, in sap cavity, air effusion is not a problem, thereby in other specific embodiment, sampling entrance and steam vent can be united two into one, even the second upper strata 500 does not arrange steam vent (as shown in figure 11), now, in the sampling end 20 of sensor body 100, because sample inlet is super wide injection port, the effect of discharge liquor intracavity air there is multi-faceted sample introduction direction, therefore in sample introduction, can be played in other position of this sample inlet.
In the above-described embodiments, the electrode of the first basic unit 200 upper surface settings at least comprises a reference electrode and at least one working electrode, has two electrical pickofves at least thereby electrically contact end 10.Preferably, in the first basic unit 200, be provided with three electrodes (electrically contact end and have three electrical pickofves), be respectively the first working electrode 11, reference electrode 12 and the second working electrode 13, each electrode is all connected with the first notch 44 (thereby being connected with slotted eye 34), as shown in Figure 7; Through hole in the second basic unit 300 comprises the first through hole 31, the second through holes 32, and 33, three through holes of third through-hole are corresponding one by one with three electrodes, as shown in Figure 6 and Figure 8.But be not limited to this, the through hole number in the second basic unit 300 can be one or more.Particularly, the diameter range of this through hole is from 0.1mm to 2.5mm, preferably, this diameter range from 0.5mm to 1.5mm, more preferably about 1mm.Above-mentioned through hole all has certain degree of depth, and this depends on the thickness of the second used basic unit 300, and when after the first basic unit 200 and 300 laminatings of the second basic unit, the region that above-mentioned through hole forms defines the area of electrode, can load chemical reagent on electrode.Particularly, the thickness of the second basic unit 300 is 0.01mm
0.2mm, preferably 0.05mm left and right.Particularly, above-mentioned through hole is all arranged in sap cavity, and they are all of similar shape and size, and is triangularly arranged, but they can have different shapes, size, put in order and relative position.Perforate can obtain by cross cutting insulant, also can obtain by cut.The second basic unit 300 can fit in the first basic unit 200 in several ways, and as binding agent, hot pressing, ultrasonic bond, photosynthesis etc., the second basic unit 300 also can make by silk screen printing insulant.In addition, the second basic unit 300 can be certain thickness one side glue.
In the above-described embodiments, the first basic unit 200 can be various insulant, and as various polymeric materials, preferred material is various plastics.The material that can be used for forming the first basic unit 200 includes but not limited to polyethylene, polypropylene, polystyrene, polrvinyl chloride, politef, Merlon, polyethylene terephthalate, poly-naphthalene, polyimides and their combination.First basic unit's 200 upper surfaces can be carbon, various metal or metal-oxide as the conductive coating of electrode.This conductive coating can obtain by various well-known methods, includes but not limited to printing (as silk screen printing), coating (as reverse roll), vapour deposition process, sputtering method, chemical deposition, electrochemical deposition.Conductive coating can be to cover on the insulant of a full wafer, if so, must be divided into some electric conductance region.This can realize by etching/line order.Etch process can chemically complete, also can be by the method for mechanical groove, or by carrying out groove with laser.Particularly, this conductive material can be but be not limited to various material with carbon elements, and various noble metals are as various metal-oxides such as gold, platinum, palladium, iridium, rhodium, ruthenium and their combination, Indium sesquioxide., stannum oxide.
In the above-described embodiments, the first upper strata 400 has identical width with the second basic unit 300 in fact, and the first upper strata 400 is as sept or pad between the second basic unit 300 and the second upper strata 500.(for example pressure-sensitive double faced adhesive tape) also made by plastic insulation material in the first upper strata 400, and the two sides of its material scribbles binding agent.There is a semicircular sap cavity notch 41 at sampling end 20, after fitting with each basic unit and the second upper strata, form the sap cavity as fluid sample chamber.The diameter of sap cavity notch 41 is at least 1mm.Half diameter of a circle can be the width that is more than or equal to the second basic unit 300, and preferably half diameter of a circle is slightly less than the width of the second basic unit 300; More preferably this radius is about 2mm to 20mm.The width of supposing each layer of insulation material layer of the biosensor that this utility model provides is 6mm left and right, and preferably, the diameter of above-mentioned semicircle sap cavity notch 41 is approximately 5.2 millimeters.Sap cavity notch 41 can have different shape and size, is not departing under the prerequisite of scope and spirit of the present utility model, and this shape can include but not limited to semicircle, circular arc, square, rectangle, triangle, trapezoid, inverted trapezoidal etc.Obviously, the thickness of sap cavity notch 41 and size have been determined the volume of thin layer pond or sap cavity.Preferably, the thickness range on the first upper strata 400 is from 0.01mm to 0.5mm, and the volume that can calculate thus this sap cavity is approximately 0.1 microlitre to 5 microlitre.
In addition, than the first basic unit 200, the second basic unit 300 and the second upper strata 500, the first upper strata 400 sampling ends 20 are slightly shorter, the leading flank that the first basic unit 200, the second basic unit 300 and the second upper strata 500 are positioned at sampling end 20 is in alignment with each other, and does not expose on the first upper strata 400, thereby leave lateral opening 91 in the both sides of the sampling end 20 of this biosensor.Therefore, sampling entrance extends to side mouth from front opening and bottom opening, thereby forms a super wide opening that exceedes 180 degree, and liquid sample can enter sap cavity from any position of the described super wide opening that exceedes 180 degree.
In the above-described embodiments, the second upper strata 500 is to be made up of plastics or polymeric material, for making the polymeric material on the second upper strata 500, includes but not limited to polyethylene, polyethylene terephthalate, poly-naphthalene, polyimides and their combination.Further, the second upper strata 500 is the capillary hydrophilic surface of promotion in the one side towards sap cavity.In fact, the second upper strata 500 can be covered by hydroaropic substance towards whole of sap cavity, then fits on the first upper strata 400.
In the above-described embodiments, on the first working electrode 11, reference electrode 12 and the second working electrode 13, can be loaded with analyte to produce the chemical reagent of detectable electrochemical signals.This chemical reagent can contain the enzyme relevant to determinand, antibody, antigen, chelating agent, substrate or their combination.Reagent and test analyte react, the signal that generation can Electrochemical Detection, this signal and the proportional relation of test analyte concentration, thereby the concentration of quantitative analysis determinand.Particularly, mentioned reagent comprises a kind of enzyme conventionally, as, glucoseoxidase, glucose dehydrogenase, cholesterol oxidase, creatininase, Lactate Oxidase, peroxidase, uricase, xanthine oxidase etc.For example, if the analyte of testing sensor is glucose, enzyme used is glucoseoxidase or glucose dehydrogenase; If the analyte of testing sensor is uric acid, enzyme used is uricase.It should be pointed out that in some cases, for obtaining test signal, can use multiple enzymes.For example, for testing the sensor of cholesterol, enzyme used comprises cholesteryl esterase, cholesterol oxidase and peroxidase.
For testing sensor is effectively worked, on the first working electrode 11, reference electrode 12 and the second working electrode 13, also need to add electron mediator, surfactant, buffer agent, stabilizing agent and binding agent etc.Preferred electron mediator or be oxide morphology, or be reduction form.In this utility model, operable electron mediator includes but not limited to various metals or noble metal complexes, as the potassium ferricyanide, potassium ferrocyanide, cobalt phthalocyanine, various ferrocene and various organic oxidation reduction amboceptor, as green in methylene blue, methylene, 7,7,8,8-four cyano, sulfur fulvalene, toluidine blue, meldola blue, N-toluphenazine Methylsulfate, 3,3', 5,5'-tetramethyl benzidine, pyrogallol, benzoquinone, woods phenanthroline-5,6-diketone etc.For example, if be glucoseoxidase or glucose dehydrogenase for constructing the enzyme of biosensor, the potassium ferricyanide can be used as electron mediator, if comprise peroxidase for the enzyme of constructing biosensor, potassium ferrocyanide can be used as electron mediator.
In specific embodiment, the second working electrode 13 is as a blank electrode, and without loading the chemical reagent reacting with determinand, make the background signal can be measured, and can be from the signal of analyte, the signal producing from the first working electrode 11, deduct, thereby eliminate the impact of various interfering materials.
In addition, this utility model also provides the second specific embodiment, and the second specific embodiment is similar to the first specific embodiment, and its difference is only, the leading flank dislocation layout on the leading flank of the second basic unit 300 in biosensor and the second upper strata 500, as shown in Figure 2.Be specially: the leading flank on the first upper strata 400 is positioned on the upper surface of the second basic unit 300, and keep the first predeterminable range with the leading flank of the second basic unit 300; The leading flank on the second upper strata 500 is positioned on the upper surface of the second basic unit 300, and keeps the second predeterminable range with the leading flank of the second basic unit 300, and the first predeterminable range is greater than the second predeterminable range.Same, " leading flank " above refers to the side that is positioned at collection terminal 20 ends.
In the second specific embodiment, because second upper strata 500 at sampling end 20 places is shorter than basic unit, make the biosensor after laminating form sample introduction opening on top.The biosensor that this utility model provides has novel super wide injection port, fluid sample (as blood sample) can be sucked sap cavity from any part of injection port, not only from front end sample introduction, also can be from the bottom of injection port, top, left comer and right corner sample introduction, so just improve widely sample introduction difficulty, especially very little to sample size sample, and the sample scattering at sampled point, and can avoid the generation of shutoff injection port.In order to make sample enter sap cavity from top entrance smoothly, can be by whole the second basic unit 300, or the part that at least the second basic unit 300 comes out is coated hydrophilic layer.
To sum up, in the first specific embodiment providing at this utility model, both sides and be provided with sample introduction opening above, add that bottom opening combines, and form super wide thief hatch, always have the direction of four sample introductions, before comprising, left and right, bottom.In a second embodiment, both sides and be provided with sample introduction opening above, the sample introduction opening that adds upper bottom portion and top combines, and forms super wide sampling opening, always has the direction of five sample introductions, before comprising, left and right, top and bottom.Three-dimensional thief hatch advantage like this, can be with illustrating by Figure 12 and Figure 18.Figure 12 to Figure 14 has illustrated that respectively blood sample enters the sap cavity of the biosensor that the first specific embodiment provides from different directions, and Figure 15 to Figure 18 has illustrated that respectively blood sample enters the sap cavity of the biosensor that the second specific embodiment provides from different directions.Attention: the approach axis of arrow express liquid sample; And for ease of explanation, Figure 14 and Figure 18 have turned biosensor respectively.
Obviously, the biosensor no matter the first specific embodiment or the second specific embodiment provide, when work, even if thief hatch is by shutoff, or blood sample scatters in collection point, super wide thief hatch still can collect the fluid sample (as blood sample) of small size (being less than 1 microlitre) in sap cavity easily, realizes accurately and measuring.
Those skilled in the art hold intelligible, although above-described embodiment has been described the structure of single biosensor, design used and material also can be made multiple sensors simultaneously.This material by the material on the material of the material of the first basic unit by from relatively large, the second basic unit, the first upper strata and the second upper strata completes, to realize batch production.
To the above-mentioned explanation of the disclosed embodiments, make professional and technical personnel in the field can realize or use this utility model.To be apparent for those skilled in the art to the multiple amendment of these embodiment, General Principle as defined herein can, in the situation that not departing from spirit or scope of the present utility model, realize in other embodiments.Therefore, this utility model will can not be restricted to these embodiment shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (10)
1. a biosensor, comprise sensor body (100) and be positioned at the inner electrode of described sensor body (100), the two ends of described sensor body (100) are respectively collection terminal (20) and electrically contact end (10), described collection terminal (20) inside is provided with the sap cavity as fluid sample chamber, it is characterized in that, the both sides of described collection terminal (20) and front side communicate with described sap cavity respectively, and the bottom surface of described collection terminal (20) is provided with the slotted eye (34) communicating with described sap cavity.
2. biosensor according to claim 1, is characterized in that, described sensor body (100) comprises the first basic unit (200), the second basic unit (300), the first upper strata (400) and the second upper strata (500) of stack successively, wherein:
The upper surface of described the first basic unit (200) is provided with described electrode;
The part that described the second basic unit (300) is positioned at described collection terminal (20) is provided with the through hole of answering with described electrode pair;
The end that described the first upper strata (400) is positioned at described collection terminal (20) is provided with sap cavity notch (41), and the upper part corresponding with described sap cavity notch (41) of described the second upper strata (500) and described the second basic unit (300) forms described sap cavity with described sap cavity notch (41).
3. biosensor according to claim 2, is characterized in that, the leading flank of described the first basic unit (200) is provided with the first notch (44);
The leading flank of described the second basic unit (300) is provided with the second notch (54);
The leading flank of described the first basic unit (200) aligns with the leading flank of described the second basic unit (300), and described the first notch (44) and described the second notch (54) position correspondence are to form described slotted eye (34).
4. biosensor according to claim 2, is characterized in that, described electrode comprises at least one reference electrode and at least one working electrode.
5. biosensor according to claim 4, is characterized in that, each described electrode is all connected with described slotted eye (34).
6. biosensor according to claim 4, is characterized in that, the described through hole in described the second basic unit (300) is corresponding one by one with described electrode.
7. biosensor according to claim 2, is characterized in that, the leading flank on described the first upper strata (400) is positioned at the upper surface upside of described the second basic unit (300), and keeps the first predeterminable range with the leading flank of described the second basic unit (300);
The leading flank on described the second upper strata (500) is positioned at the upper surface upside of described the second basic unit (300), and keeps the second predeterminable range with the leading flank of described the second basic unit (300), and described the first predeterminable range is greater than described the second predeterminable range.
8. according to the biosensor described in claim 2-7 any one, it is characterized in that, described sap cavity notch (41) is arc-shaped slot.
9. biosensor according to claim 8, is characterized in that, the part that described the second upper strata (500) is positioned at described collection terminal (20) is provided with the steam vent (74) communicating with described sap cavity.
10. biosensor according to claim 9, is characterized in that, described steam vent (74) has multiple, and arranges successively along the bottom land of described arc-shaped slot.
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104407028A (en) * | 2014-11-27 | 2015-03-11 | 三诺生物传感股份有限公司 | Method and system for controlling test strip electrodes |
CN105572199A (en) * | 2015-12-17 | 2016-05-11 | 三诺生物传感股份有限公司 | Working electrode biological reactant and electrode type test strip |
CN115236155A (en) * | 2022-06-27 | 2022-10-25 | 南京纽邦生物科技有限公司 | Biological sensor |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104407028A (en) * | 2014-11-27 | 2015-03-11 | 三诺生物传感股份有限公司 | Method and system for controlling test strip electrodes |
WO2016082441A1 (en) * | 2014-11-27 | 2016-06-02 | 三诺生物传感股份有限公司 | Test strip electrode control method and system |
US10156538B2 (en) | 2014-11-27 | 2018-12-18 | Sinocare Inc. | Control method and system for test strip electrodes |
CN105572199A (en) * | 2015-12-17 | 2016-05-11 | 三诺生物传感股份有限公司 | Working electrode biological reactant and electrode type test strip |
CN115236155A (en) * | 2022-06-27 | 2022-10-25 | 南京纽邦生物科技有限公司 | Biological sensor |
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