CN203379477U - Micro-needle roller device - Google Patents
Micro-needle roller device Download PDFInfo
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- CN203379477U CN203379477U CN201220695917.4U CN201220695917U CN203379477U CN 203379477 U CN203379477 U CN 203379477U CN 201220695917 U CN201220695917 U CN 201220695917U CN 203379477 U CN203379477 U CN 203379477U
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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Abstract
The utility model relates to a skin beauty treatment and administering device and a use thereof, and concretely relates to a micro-needle roller device. A protection cover is added, and a multi-direction slide or a multi-angle mobile embedded movable connection mode is used for a handle of a fixed frame and a support, a transdermal drug delivery, transdermal absorption, and sustained release system is improved, a lot of fine pipelines can be made by a needle roller in a short time, medicines and beauty treatment products can directly go through the skin epidermal layer and hypodermal cells, an epidermal wound is small, healing is fast, possibility of bacterium infection is greatly reduced, skin hardening or skin cell contraction are prevented, epidermal tissues are not thinned, multiple uses are allowed; the micro-needle roller device can be used for massaging head skin to stimulate growth of hair. The micro-needle roller device is also advantaged by simple manufacture technology, low cost, low side-effect, obvious effect, good controlling performance, convenient use, capability of being mastered via simple training, higher practicality, direct use for daily life, suitability for large scale production and business applications for industries such as medicines, beauty treatment, etc. and obvious effect.
Description
Technical field
This utility model relates to the technical fields such as medicine, beauty treatment, specifically relate to a kind of painless doser and structure and purposes that gives medicine, cosmetics etc. through skin, more particularly relate to a kind ofly for transdermal administration or cosmetics, reach that rapid transdermal absorbs or a kind of painless micropin roller devices and structure and the purposes of the good results such as slow release.
Background technology
(1) research overview of micropin roller
1, general introduction
21 century, medical circle has faced a new problem at medical domain: how medicine correctly is transported to the position that need to treat, drug effect is maximized the performance.The beauty treatment circle also faces same problem, more why be known as the high-tech nanotechnology, raw material is first-class and the product such as expensive beauty cream, cosmetic cream after use, effect does not have expectative so obvious, so medical circle is unprecedentedly active about the research of the science such as percutaneous dosing, Transdermal absorption, slow release in recent years.The gene biological cosmetics can be to the Skin Cell reparation of reforming, but how these compositions is transported to the needed position of skin to cell metabolism generation effect, becomes a difficult problem of gene biological beauty treatment.
Horny layer is the protective layer that skin surface is the firmest; it is also can not the go directly major obstacle of skin bottom of nutrient in general cosmetics; medical circle is constantly sought new method, allows the nutrition of beauty treatment aging resistance can penetrate horny layer, directly enters each layer of generation effect of skin.Many beauty apparatus are all to see through ultrasound wave intermediate frequency unidirectional current on the market, attempt to strengthen nutrient substance and pass through cuticular ability; How, effect is also not remarkable all the time, and this class technology of life-time service also can cause corse sweat pore.
Along with growth in the living standard, people are increasing to the demand that makes skin rejuvenation, health, in order to make skin, reach cosmetic result, and at present method commonly used has: grind off epidermis, pickling, laser and remove epidermis etc.The common ground of these methods is: they are all the epidermal tissues of removing skin surface, the epidermal tissue that makes the dermal tissue manufacture of epidermal tissue below make new advances, thus reach the effect that makes skin more healthy and smooth.But, use these methods also to have a lot of drawbacks to skin, the epidermis of human body is that the people resists the extraneous outermost layer barrier infected, and in old epidermal tissue, is removed and new epidermal tissue not yet grows in complete process, and skin very easily is subject to the infection of antibacterial and diseases induced; On the other hand, the convalescent period of these Therapeutic Method is long again, is generally the several months; And the skin of processing through these methods is understood attenuation, if overtreating possible scar also, so, for most people, these Therapeutic Method could only be used once at most.
2, micropin U.S.A moulds definition and principle
By scientific and technological development, laser beautifying is becoming the first-selection treatment of female skin aging, mottle, wrinkle etc. symptom with brand-new attitude.And biological beauty and skin nursing are also just constantly being innovated with completely new concept and technology, biological beauty is China's popular new technique instantly, particularly micropin beauty treatment, and one of popular new technique of first electing especially, its successful, simple to operate,
Now by vast beauty treatment mechanism, approved, but pain is still the major issue that microneedle therapy faces, the painless micropin of follow-up release can solve problems effectively, and it is wherein a kind of that micropin U.S.A moulds.
Micropin U.S.A moulds beauty treatment and comes from the U.S., claims again micropin mesoderm beauty curing (mesotherapy), or claims microneedle therapy (to be called for short: MTS).
It is the micropin that rolls on skin that micropin U.S.A moulds, use the micropin roller to stimulate human body skin, within very short time, micropin can produce and surpass 200 between the skin aspect, 000 fine conveyance conduit, make the various active compositions such as Growth of Cells peptide gene active component and multi-nutrition element directly effectively infiltrate deep skin, the product assimilation effect is more than 4000 times of common spread product; Be equipped with wrinkle removal, speckle dispelling, whitening, the products such as striae gravidarum, scar eliminating of repairing, dispel, can efficiently repair rapidly, active cell, promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination cicatrix, mottle, smooth wrinkle, thereby reach, subtract light wrinkle, treatment cicatrix, anti-acne, anti-acne seal and striae gravidarum, skin whitening, subtract the light color speckle, improve eye wrinkle-removing, black eye, tighten up and promote the ideal effect such as skin of face tissue.
The principle that micropin U.S.A moulds is a kind of therapy of being improved looks for the skin mesoderm, this therapy is skin care activity composition or nutritional labeling to be input to mesoderm by certain special installation (that is: instrument is moulded by U.S.A) play a role, and this U.S.A to mould instrument be exactly micropin roller (B.N.M meso Roller or Meso Roller, sometimes also be called for short: micropin) or U.S.A mould rifle (Meso Gun), different equipment has different action principles: the micropin roller is to utilize many little pins (small syringe needle) on roller to penetrate horny layer, chafe, within very short time, micropin can be made and surpass millions of ultra micro tubules, be equipped with wrinkle removal, whitening, repair, the striae gravidarum of dispelling, the specially good effect products such as scar eliminating, make active component effectively infiltrate skin and the importing of aidant component, subtract light wrinkle thereby reach, treatment cicatrix and striae gravidarum, the skin whitening, subtract the light color speckle, improve eye wrinkle-removing and black eye, tighten up and promote the ideal effects such as skin of face tissue, simultaneously micropin stimulates skin corium, and percutaneous self-healing ability promotes the ossein hypertrophy, the thickness hypertrophy that can make skin epidermis approximately 8%, can the match in excellence or beauty plastic operation of laser and filled type of its effect.And the microsyringe that rifle is automatization is moulded by U.S.A, directly composition is expelled to subcutaneous.These two kinds of equipment can be selected according to the needs of self, and the micropin roller is safe, easy to use, be widely used, and U.S.A mould rifle and mainly some superiority arranged tackling aspect partial-depth wrinkle and local weight reducing fat melting.
Micropin U.S.A mould be utilize a kind of deep layer be used for skin is carried out to aesthetic nursing, compared with superficiality nursing in the past, this treatment can reach effect more thoroughly, but also can guarantee can not cause extra infringement to skin, so be a kind of desirable beauty treatment means.
Micropin U.S.A moulds and can open towards the passage of skin basal layer moment, somatomedin is transported to the skin bottom endlessly: can activate self cell regeneration, strengthen self synthetic and Secretion, endogenous replenishing collagen and elastic fibers, remove interior free yl, reduce biological oxidation and aging; Can directly act on basal layer melanin, check melanin generates, and spot fading is accelerated metabolite and transported, and removes the free radical that causes human senility, thus delaying skin aging, and that skin and muscles are fair is smooth in order, fine and smooth as silk; Wrinkle removal simultaneously skin becomes delicate smooth and compacts beautifully, strongly promotes division and the growth of Skin Cell; Irritate the synthetic and secretion of hyaluronic acid, collagen protein and glycoprotein etc., make the wrinkle of skin Lock-out, skin recovers gloss and elasticity, is applicable to the dark person of local wrinkle.In the time of the micropin chafe, can also stimulate the hypertrophy of skin corium collagen and fibroblast, not only small wound healing is rapid, and preventing from scar.
Micropin U.S.A moulds and can effectively improve the face skin problems such as sunburn, chloasma, freckle, plumbous mercurialism, facial pigmentation skewness, the colour of skin are dark and gloomy, the coarse tarnish of skin; For acne pothole skin, the contained biology acne pothole skin-active composition of dispelling directly acts on the fibrocyte of deep skin fracture, promotes collagen protein synthesis, regenerate fibrous tissue, thereby arrive the reconstruction of deep layer reticular fiber structure, calm down the acne pothole, reappear smooth fine and smooth skin.
3, the characteristic of micropin beauty treatment
Effect and the characteristics of micropin beauty treatment:
1. utilize the normal healing ability of wound, can not make the skin hardening or cause that Skin Cell shrinks.
2. micropin can be made a large amount of microtubules, makes active component effectively infiltrate skin (only need to use five minutes, just can produce and surpass 200,000 micropores).
3. side effect is extremely low.
4. use after microneedle theraphy nursing simple and easy, can carry out general outdoor activities, comprise and getting sun.
Advantage is moulded by micropin U.S.A:
Naturality: do not affect histrionic muscles and face nerve, expression natural shape harmony after reduce wrinkle.
Safety: with the human body homology, without obviously rejection and side effect, after treatment, leave no trace, cicatrix, safe and reliable.
Persistency: promote human body cell continuous release collagen protein, elastin laminin, curative effect is permanent.
Simplicity: with doing with walking, noinvasive is painless, does not affect work and life, also referred to as " lunch break erugation ".
High efficiency: dispel true property wrinkle and reach more than 95%, reverse aging, young 5～10 years old.
The problem that the micropin roller solves:
1. subtract light wrinkle, bring out the ossein hypertrophy, treatment areolar tissue, skin thickness problem, treatment cicatrix and striae gravidarum;
2. skin whitening, subtract the light color speckle, improves eye wrinkle-removing, black eye, stimulates the ossein hypertrophy, tightens up and promote the skin of face tissue;
3. administer alopecia, care and household etc. and effectively carry nutrient.
Now a lot of cosmetics all have damage in various degree to skin, be undoubtedly a kind of injury concerning using such personage that likes to be beautiful, so they are more careful when selecting cosmetics, and the harm that micropin U.S.A moulds is almost non-existent, be substantially without a kind of more safe and reliable beauty method damaged to skin.
It is to mould instrument by U.S.A to reach cosmetic result after in the skin of the required nutrient importing of skin needs change, making skin fully absorb that micropin U.S.A moulds, it is different from other beauty method, be need not operate on, need not take medicine, accurate effective beauty method, it is a kind of point-to-point beauty method: the integrity that does not destroy skin texture, set up a large amount of skin microtubules, the transport substrate cosmetics; Progressively remove deep skin toxin and refuse; The chafe self-healing ability, promote skin metabolism, keeps skin elasticity and handsome U.S.; Active cell, reparation damaged tissues, participate in cellular metabolism directly, reaches wrinkle removing, lifting, whitening, antidotal effect; Utilize the normal healing ability of wound, induce nutrition and the collagen growth of skin self; Safe and reliable having no side effect.
The harm that micropin U.S.A moulds thus is almost non-existent, by short, the instant effect of time of its beauty treatment, without cicatrix, the crowd of various skin problem is suitable for.
The rise that micropin U.S.A moulds, solved the century difficult problem on the world of medicine, beauty treatment circle.Use B.N.M meso Roller chafe, make a large amount of microtubules, make active component effectively infiltrate skin.Trickle rolling acupuncture simultaneously, can also stimulate the hypertrophy of skin corium collagen protein and fibroblast.This kind of Wicresoft is that use is also less than 30G fine needle " micropin " carry out the aculea action, not only " Wicresoft hinders " healing is rapid, and preventing from scar.In other words, directly by Growth of Cells peptide gene active component and multi-nutrition element etc., give the skin cell rapid osmotic of different depth via very tiny pin hole.These tiny Wicresofts can't cause the excessive wound of skin and burden, in reparation period, can also activating cell, and promote collagen protein and elastic fiber hypertrophy, use and fill up pothole, desalination pox scar color element; + 6 also can allow Skin Cell see through microtubule directly absorbs the gene activity composition that skin needs, and assimilation effect approaches absolutely, therefore can give different formulas for demands of individuals, really makes new skin live again from inside to outside, thoroughly improves skin quality.
4, micropin roller
(1) textual investigation
The micropin roller is that instrument used is moulded by micropin U.S.A.Micropin, the needle set name, the appearance of micropin one word, can find at Huangdi's Internal Classics, and it refers to the fine fine little needle sets such as acupuncture needle." the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " in Huangdi's Internal Classics: " wanting, with logical its passages through which vital energy circulates of micropin, to adjust its vim and vigour ... ", nowadays, micropin just is widely used in beauty treatment.
The justice of micropin has two:
1. small pin, little pin." Plain Questions treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it is controlled should micropin." the Wang Bingci notes: " micro-, also tiny.Tiny pin, pulse-taking declines and contains also." " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint ": " wanting of little pin easily oldly and difficult enters." " class is through 19 volume acupuncture classes one ": " little pin, the i.e. meaning of micropin above.”
2. nine kinds of needles." Plain Questions treatment in accordance with local conditions opinion ": " its sick arthritis with muscular contracture, it is controlled should micropin.Therefore the nine kinds of needles person, also come from south." " Plain Questions knowledge ": " [nine kinds of needles], high cloud: ' " Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles opinion " Yellow Emperor, a legendary ruler want with logical its passages through which vital energy circulates of micropin.Micropin, little pin also.The little pin of qi uncle opinion and and in nine kinds of needles, therefore the person that says the nine kinds of needles also comes from south.' letter press: " the nine kinds of needles twelve source acupoint ": ' Supreme Being asks useless stone needle, wants with logical its passages through which vital energy circulates of micropin.And qi uncle answers to start from one finally nine.' micropin be nine kinds of needles, for stone needle, outside non-nine kinds of needles, micropin is arranged.Will cloud: ' micropin person.Its cutting edge of a knife or a sword is fine.The pin of shallow puncture also.' fear non-ly be.”
The micropin roller is medicine in France expert Horst doctor's invention the earliest, adopts Switzerland's high-quality medical treatment rustless steel, continues to use the casting method of German craftsman invention in 1896, in the subzero 60 supercool freeze techniques manufactures of spending Celsius, forms.So, the based on very high purity of micropin, very hard.
The current Anti-slip handle of a micropin roller based on bionic design, the pure moulding of streamlined fashion, run-bake-needle fault not, needle point is round and smooth sharp, is the latest generation micropin roller of current leading industry.
(2) basic structure and specification
On the micropin roller, with a lot of diameter micropins the same with spacing, different needle roller spacing and the diameter of its micropin is understood some difference, is to select applicable micropin specification according to skin conditions, is generally the micropin that pin length is 0.3～1.25mm.Longer micropin is more deep to the stimulation of skin, and also relatively high to treatment personnel specification requirement, not the longer the better for the micropin that treatment is used; If be not suitable for patient's skin thickness, that effect can only be reciprocal, because it is to sting the expelling pathogenic factors from the exterior skin by micropin that the principle worked is moulded by micropin U.S.A, import to be applicable to again the essence of relevant skin problem or medicine etc., allow like this within essence or medicine etc. directly are penetrated into epidermis, improve and repair cortical tissue and cell.
So the treatment of the saturating property of such thorn need to allow professional doctors and nurses operate in medical cosmetology mechanism, people's one pin, strict sterilization, do not reuse, the safety of guarantee treatment.
Micropin specification (mm i.e. millimeter, is the length of pointer, is not the width of roller):
1. 0.25mm: be generally used for red blood streak, cell is more living;
2. 0.5mm: be generally used for wrinkle removal, whitening, speckle dispelling, receipts fine, soft fur hole;
3. 1.0mm: be generally used for recessed scar, pox hole, cicatrix reparation;
4. 1.5mm: be generally used for striae gravidarum.
(3) related products
The product that report is arranged at present, for example Mesomed micropin rod is to make with plastic cement, volume is light and handy, the above's about 200 very tiny medical titanium syringe needles that distribute.
A kind of commercially available micropin roller product section details is as follows:
Weight: 55 grams (comprising packing)
Package size: 16cm * 3.5cm * 5.5cm
Color: white orange or transparent orange
Micropin material: medical use rustless steel (silver)
Micropin is arranged: yi word pattern is in line
Ai disappears: EQ Gas, the Gamma Ai ray that disappears, ethanol, the UHT high temperature Ai that disappears
Abandon: be (Ai unless again disappeared)
Pin is long to be selected: 0.2mm/0.25mm/0.3mm/0.5mm/0.75mm/1.0mm/1.5mm/2.0mm/2.5mm/ 3.0mm
OEM/ODM selects: can
Environmental conservation: identify the greening material
Specification: ISO11137, CE, FDA
On the micropin roller, micropin quantity is 540, and pain reduces by half than common micropin; The kermesinus roller, bright pearl white handle.
The solid roller design of this product, guarantee to use safety.
The solid roller design of Britain's micropin is derived from the requirement of FDA and CE blueprint, and has adopted seamless technology production to guarantee that antibacterial can not grow at roller after sterilization, but more stops to appoint the disaster of bacterial invasion.Occurred on the market that recently some are convenient to the low-cost hollow roller micropin of producing, hollow roller can lower the trouble of much installing undoubtedly, but this designs exhausted large health test problems is but arranged.For example, in nursing the course for the treatment of, coat because of carelessness the fine blood streak remaining on facial skin care item or micropin and also can enter through the joint close on hollow roller the middle part of roller.If disappear, Ai does perfectly not, and the micropin roller that this FDA of not meeting or CE require is definitely likely make skin be subject to the crisis of bacterial invasion and leave behind permanent injury.
The whole handle of micropin requires through meeting ergonomic designs, and this design can reduce the strain on finger effectively and the grip that increases between finger tip and handle has avoided unclamping because of carelessness the injury that handle can be made (for example the barefoot hands is slippery absent-mindedly).The material that micropin is used can bear high temperature, heat-resisting not modification.
Have a kind of Product Report of painless aculea rolling instrument to claim: the life-span of high-quality micropin roller and effect are that the grinding state by the material of micropin itself and needle point determines.192 micropins of the painless micropin roller of this product are to be made by Korea S's high density medical stainless steel, in conjunction with international advanced pin technology processed, draw point is hard, and atomic thin, so can not cause client's pain while thrusting skin, the common needle roller of the above painless needle roller contrast same specification of 0.5mm could make client's pain reduce more than 50% 0.25mm it is 100% painless that the needle roller of length can reach!
Also have a kind of Product Report to claim: the structure of skin needle roller is composed as follows: needle body adopts selects 0Cr19Ni9 or other austenitic stainless steel wires in GB/T4240 " stainless steel silk ", through sharpening, injection moulding, inlay, the operation manufactures such as assembling, heat-sealing form.It is 0.2mm, 0.3mm, 0.5mm, 1.0mm, 1.5mm, 2.0mm that this product exposes the outer needle body length of surveying of roller sheet; The needle body diameter is 0.16mm, 0.18mm, 0.20mm, 0.22mm, 0.25mm, 0.30mm; The technical parameter of this product is: needle body hardness >=460HV, the numerical value of 0.2kg surface roughness Ra is not more than 0.5 μ m.The design of needle roller spreads all over intensive, and pin and pin only have 0.3mm apart, can reach the optimal healing effect to wound.
(4) relevant patent application
Patent of invention " a kind of miniature needle roller " (application number: 200810089036 is arranged, the applying date: 2008-04-16) claim: a kind of miniature needle roller, comprise a plurality of fine needle substrates 10, cylinder substrate 20 and pair of discs 30, described fine needle substrate 10 is comprised of a plurality of microneedle 11 of configuration at a certain distance, and there is jut 12 lower end, both sides of fine needle substrate 10; The both sides of described cylinder substrate 20 are provided with patchhole 21, and the jut 12 of fine needle substrate 10 lower ends, both sides can directly be inserted in this patchhole 21; Described disk 30 comprises the fixedly insertion section 31 of annular.Described whole cylinder substrate 20 and fine needle substrate 10 in conjunction with after, both sides in conjunction with protuberance 13 form an integral body in conjunction with fixed part 22, be inserted in the fixedly insertion section 31 of above-mentioned disk 30, while preventing from rotating, fine needle substrate 10 and cylinder substrate 20 break away from.After adopting this utility model, its simple and convenient assembly, save time and laborsaving, reaches the effect that fraction defective is minimum, productivity ratio is the highest.In addition, the effect that in the time of can also reaching pre-anti-rotation, fine needle substrate and cylinder substrate break away from mutually.
Utility model patent " skin needle roller " (application number: 200720035626.1 is arranged, the applying date: 2007.03.23) claim: a kind of skin needle roller, it comprises roller mount, be arranged at a plurality of needle bodies on the external peripheral surface of described roller mount, the diameter of described each needle body is 0.07～0.35 millimeter, and the length of exposing at the roller mount Outboard Sections of described each needle body is 0.1～3 millimeter.Drive needle body by roller mount rolls on the skin of human body, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thereby chafe, promotion ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be manufactured the epidermal tissue made new advances, thereby reaches the effect of health rejuvenation skin.Use this skin needle roller, can reach without removing epidermal tissue the effect that makes epidermal tissue's regeneration, and, because the epidermis wound is small, healing stage is very fast, the probability that is subject to the antibacterial infection also is lowered; In addition, it can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, and application risk goes the method for epidermis far below tradition.
(5) up-to-date basic technology progress
" Science and Technology Daily " December in 2011 reports on the 23rd: the engineer develops painless silk micropin, can accurately control drug release.According to U.S.'s physicist, organize 22 (Beijing time) of net December, the bioengineer of engineering college of U.S. Tufts University to develop a kind of painless silk microneedle device, can be by sustained release in long-time, the unnecessary medicine without cold preservation.This micropin has biocompatibility and biological degradability concurrently, can under normal temperature and pressure, manufacture, and can load the biochemical drug easily be damaged and keep its activity.Relevant paper is published on " advanced function material " website.
Demonstrator Trials shows, the New type silk micropin can be sent macromole, catalator medicine, horseradish peroxidase with controllable speed, also keeps the biological activity of medicine simultaneously; The silk micropin that loads tetracycline can also suppress the growth of staphylococcus aureus, shows that this micropin is in delivering therapeutic agents, also has the potential value of prevention local infection.
Although some medicine can directly be swallowed, some can't bear the gastrointestinal digest and decompose.Hypodermic mode is more painful, can not slowly discharge medicine.Only have small-molecule drug seldom to enter in body by the mode sticked.Silk micropin 1 micron size only, can penetrate upper strata skin and can not touch nerve, is a kind of new painless type mechanisms for drug release.But have at present a lot of difficult problems to hinder the development of this technology, as the vulnerability of biological product make medicine in manufacture process loss of activity, can not accurately control drug release or put infection that skin penetration that medicine is too much, small brings etc.
For these problems, research worker has been developed new fabrication schedule, and process comprises pressure, temperature and water treatment etc.They are formed from aluminium the micropin master mold, line up 500 microns high, and needle type radius is less than the array of 10 microns; With resilient dimethione, (be called for short: PDMS) be cast on master mold and form die; Again the silk protein solution that medicine is housed is injected to die.After the silk drying, then the silk micropin that comprises medicine is taken off to further processing.Post processing comprises with steam limbers up it, then, by the various processing of temperature, machinery and electronics, makes it have corresponding diffusibility and drug releasing rate.
Research worker means, regulates the post-treatment condition of fibroin, as changed drying time, is mainly the secondary structure of controlling it, can accurately control drug releasing rate.Through discharging the dynamic model test, drug releasing rate can reduce by 5.6 times, and this has solved a drug release difficult problem for a long time, can also be used in other biological storage aspect.
Paper co-author, Ta Fusi biomedical engineering chairman David Kapp orchid also point out, this micropin is very flexible, can enlarge or dwindle, transport or store without cold preservation, and it is easy just as plaster or binder that management is got up.
The non-fresh thing of microneedle therapy.Ancestor " the Ling Shu Miraculous Pivot or Divine Axis nine kinds of needles twelve source acupoint " just has cloud: " wanting, with logical its passages through which vital energy circulates of micropin, to adjust its vim and vigour ... ".Although the size of those micropins cannot compare really with the present pinpoint array less than 10 microns radiuses, the principle of from outward appearance to inner essence curing the sickness to save the patient, broadly similar.As for the main innovate point of Tufts University, in fact show that they select silk and organosilicon to make base material, utilize material behavior to realize slow release, controlled release.When microneedle therapy, heal to become in maturation, examination water can not be the patient of hanging down, but the woman that large quantities of wish is held for happy own person.
(2) research overview of needle roller
1, general introduction
The product somewhat similar with micropin has the device containing needle roller, is a kind of for the particularly machinery of the Suzhou embroidery skill of handling needles of embroidering.
2, needle roller
Needle roller (needle roller) refers to the small diameter cylinders roller that the length-to-diameter rate is greater than 2.5, belonging to the rolling bearing (three grades of subjects) in the mechanical machine components of one-level subject (secondary subject) of application branch of learning, is a kind of in the sewing of one of Suzhou embroidery skill of handling needles bar.Palpus, the eyebrow of the suitable embroidered beast of this needle roller, personage's hair, the pleat stricture of vagina of clothes and thin narrow pattern line kind etc.The tight Jing'an of two lines, become striped, and the lines turnover is more flexible.Embroider straight line, curve all more appropriate.
The embroidery step: after rising before the grain pattern lines, fall, the pin pin is tightly secret, and the same ，Yue of lines length divides in mono-city left and right.Turning point can be slightly short, so that turnover.After embroidering the first pin, second pin that should fall at the first pin 1/2nd places, ensconce under last pin needle tracking.The 3rd pin drops on 1/2nd places of the second pin, tightly presses the end of the first needlework bar, by that analogy.
Needle bearing (needle roller bearing): referring to that rolling element is the radial bearing of needle roller, is the roller bearing with cylindrical roller, its diameter relatively, and roller is not only carefully but also long.This roller is called needle roller.Although have less cross section, bearing still has higher load-bearing ability, therefore, is specially adapted to the restricted occasion of radial space.
The needle roller contoured surface shrinks a little at the proximal end face place.The result of needle roller and Race Line Contact correction can avoid producing damaging edge stress.The supporting rollern needle bearing is the heavy wall outer ring, through the high nitrogen of high temperature, quenches, and the roller of high-accuracy sorting, by the lip-guided of high rigidity outer ring, utilizes the wire contact, and roller can directly easily rotate on raceway, and can bear huge load.For removing stress, the outer ring of support roller adopts the cambered surface design, all size models such as curving roll is with single, double sealing ring, is not with sealing ring, band sealing ring.Band sealing ring storage grease space is large, provide the lithium saponify permanence lubricated, and extends lubricated interval.The sealing ring material is band skeleton acrylonitrile-butadiene rubber or ST12, and its operating temperature scope is-30 ℃ to+100 ℃ or-30 ℃ to+180 ℃.The curving roll of closely packed formula can bear heavier extremely strong load and high performance operation.The RSTO outer ring is without rib, without the inner ring supporting rollern.
The characteristics of needle bearing and purposes:
Needle bearing is equipped with (roller length is diameter 3～10 times, thin and long roller, diameter generally is not more than 5mm), so the radial structure compactness, when its internal diameter size is identical with the other types bearing with load-carrying ability, the external diameter minimum, be specially adapted to the radially restricted supporting result of installation dimension.According to the use occasion difference, can select bearing or needle roller and retainer assembly without inner ring, the journal surface now matched with bearing and shell aperture surface are directly as the inside and outside rolling surface of bearing, for guaranteeing load-carrying ability and behavior in service and having the lasso bearing identical, the hardness of axle or shell aperture raceway face, machining accuracy and surface quality should be similar with the raceway of bearing ring.This kind of bearing only can bear radial load.
The type of needle bearing:
The bearing that can be used for common engineering, as: open type drawn cup needle roller bearing, closed drawn cup needle roller bearing, tool inner ring needle bearing and do not have inner ring needle bearing/without inner ring without the retainer needle bearing, retainer is arranged and fills needle bearing without retainer.
Although above-mentioned needle roller device is different from technical field of the present utility model, with beauty treatment micropin roller devices described in the utility model, the place that can be worth reference and reference is also still arranged on the product manufacturing technology.
Therefore, find novel, Transdermal absorption better effects if, use that painless micropin roller devices is still imperative more easily.
By literature search etc., up to the present, not yet find that there is the painless micropin roller devices product of renewal and the report of the aspects such as structure and purposes thereof.
Summary of the invention
The technical problem of the required solution of this utility model is to disclose a kind of a kind of painless micropin roller devices and structure and purposes that reaches the good results such as Transdermal absorption, slow release for transdermal administration or cosmetics, this device has the new roles such as Quick medicine, easy to use, infection chance is few, can be used in the technical fields such as medicine, beauty treatment, the above-mentioned defect existed to overcome prior art.
That is to say, this utility model is for the deficiencies in the prior art, by practical studies and theory studies such as zoopery and clinical trials, one of purpose is intended to provide a kind of new doser, and a kind of safer, more convenient, painless micropin roller devices of more easily controlling is provided; Two of the purpose of this utility model is to provide a kind of purposes of new micropin tourelle.
Micropin roller devices described in the utility model (sometimes also claim: skin micropin roller devices, micropin tourelle, skin micropin tourelle, needle roller device, skin needle roller device, skin needle roller etc.) refers in the technical fields such as medicine, beauty treatment, a kind ofly is directly used in product quick, painless Transdermal absorption; Preferably be directly used in the product of beauty industry, i.e. the U.S. molding product of a kind of new micropin.
(1) technical conceive
Explore and improve existing micropin technology and supporting micropin roller devices is a urgent task of Chinese medical, beauty industry safety, Quick medicine or cosmetics, particularly to study and improve and can fast medicine, cosmetics correctly be transported to the subcutaneous location that need to treat, effect is maximized, be the forward position of the academic researchs such as percutaneous dosing, Transdermal absorption, slow release, can solve a difficult problem of biological beauty.
Horny layer is the protective layer that skin surface is the firmest; it is also can not the go directly major obstacle of skin bottom of effective ingredient in general medicine, cosmetics etc.; medical circle, beauty culture are all constantly being sought new method; allow relevant effective ingredient can penetrate horny layer, directly enter each layer of generation effect of skin.
In actual use, the designer finds existing painless micropin roller devices, and general skin micropin roller devices for example is when particularly facial skin is used in use, when processing skin, higher to operation requirements:
The one, while dragging back and forth skin micropin roller devices, skin creases easily, if excessive velocities causes hemorrhage or pain, need to take moderate speed;
The 2nd, need skin surface to be processed likely uneven, particularly in face, often need to convert at any time the angle and direction dragged in the process dragged, increase the uncontrollability of operation, improved the requirement of operation;
The 3rd, the needle body length of same skin micropin roller devices is fixed, different parts or different demand to same client, often need to use two or more skin micropin roller devices, increase customer cost, use in turn different skin micropin roller devices, also increased the chance that may cause infection;
The 4th, need to first process skin, after forming a large amount of trickle ducts, could administration or cosmetics etc., be difficult to carry out simultaneously, operation is not in time or other are improper, has increased the chance that may cause infection.
Therefore, for reducing infection chance, improving safety, increase control convenient, convenient more people use, and particularly are convenient to client oneself and directly use this micropin roller devices, according to this idea and thinking, the designer has consulted a large amount of data, compare existing various product, by experimentation and analysis and theory study repeatedly, successfully obtain result of study and the application product of expection.
This utility model be mainly for utility model patent " skin needle roller " (application number: 200720035626.1, the applying date: 2007.03.23) carry out improvedly, and its purposes is expanded to a plurality of technical fields such as medicine, beauty treatment.
The particularly woman's beauty treatment of improving looks is the focus that the whole world all is concerned about, rapid transdermal administration, Transdermal absorption, slow release etc. are also the focuses that pharmaceuticals industry generally is concerned about.When microneedle therapy, heal to become in maturation, the woman that will have more large quantities of wishs to hold for happy own person.If spread is used this utility model micropin roller devices, this technology will have significant social benefit, economic benefit.
(2) micropin roller devices
This utility model has carried out many-sided test and study to the micropin roller devices at beautifying skin, rapid transdermal administration, Transdermal absorption, slow release etc. and has explored.
The technical solution of the utility model is as follows:
A kind of micropin roller devices, it comprises fixed mount, needle roller, 8 three part (see figure 1)s of protective cover:
Described fixed mount comprises handle 1, the support 6 be flexibly connected with handle 1 by junction 9, the roller bearing 4 be connected with support 6; But the embedded mode that described handle 1 preferably adopts multi-faceted slip or multi-angle to move carries out activeness with support 6 and is connected (seeing Fig. 1, Fig. 2), described handle 1 and the junction 9 of support 6 are that embedded mode that the multi-faceted slip of employing or multi-angle move carries out activeness and is connected;
Described needle roller comprises roller mount 2, be arranged at a plurality of needle bodies 3 on the external peripheral surface of roller mount 2, the roller bearing hole 7 of offering at the axial line place of roller mount 2; By roller bearing 4 by roller mount 2 pivotal mounting on support 6, be convenient to control roller mount 2 roll (seeing Fig. 3, Fig. 4) by the mode pushed away or draw on human body skin;
Described roller mount 2 is hollow cylinders, preferably hollow cylinder; Needle body 3 is hollow needle body; And each row needle body 3 is directly fixed on roller mount 2, on the external peripheral surface of roller mount 2, by multiple row, distribute, preferably by 3～9 column distributions, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2; The material that roller mount 2 is used has elasticity, and when dragging this utility model device, under the pressure dragged, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3;
The diameter of described each needle body 3 is 0.07～0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1～3 millimeter; Drive needle body by roller mount 2 and roll on the skin of human body, needle body can pierce through the epidermal tissue of skin, and it is caused to small wound, then reaches dermal tissue;
Described protective cover 8(is shown in Fig. 2, Fig. 3, Fig. 5, Fig. 6) be that its bottom surface has the three-dimensional cover that the needle body 3 extending part sizes on a breach 12 and this breach 12 and roller mount 2 adapt, and this protective cover 8 is installed on support 6, be that middle part or both sides 11 by its upper end are connected with support 6, preferred mode is that protective cover 8 is to be connected with support 6 by both sides 11; Protective cover 8 can be to be fixedly connected with the connected mode of support 6, can be also in the situation that needle body 3 length are fixing, according to the requirement of needle body 3 exposed lengths, carries out the packaged type connection, and preferably packaged type connects; This packaged type connects the connecting portion be included on support 6 and presets 2～5 holes, draw-in groove or chute 10, and the middle part of protective cover 8 upper ends or both sides 11 are connected with hole, draw-in groove or chute 10, preferably 3 holes, draw-in groove or chutes;
It is a plane or curved surface that these protective cover 8 bottom surface breach 12 are sentenced outer part, preferred curved surface, further preferred arc-shaped curved surface; While dragging back and forth skin micropin roller devices, skin creases easily, and uses this protective cover 8; can be before needle body 3 arrives skin; bottom surface by this protective cover 8 first makes skin smooth, solves back and forth the unmanageable problem of dragging speed, makes this utility model device be easier to control.
This utility model is mainly used in the percutaneous drug delivery at the positions such as the health, face of human body or cosmetics etc., can be used for the direct administration of human buttock or skin of abdomen to reach the effect of quick weight-lossing, be preferred for the percutaneous drug delivery of human face or cosmetics etc., and except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Existing micropin roller devices (" skin needle roller " application number: 200720035626.1, the applying date: 2007.03.23) comprise fixed mount and needle roller two parts, described fixed mount comprises handle 1, roller bearing 4, support 6; Described needle roller comprises roller mount 2, needle body 3, roller bearing hole 7; Each modular construction and basic annexation are as follows:
Described handle 1 is fixedly connected with support 6, and support 6 is connected with roller bearing 4; Described roller mount 2 comprises a plurality of wheel sheets 5 in the form of annular discs, described a plurality of sheet 5 of taking turns is arranged in order and connects in end, described a plurality of needle body 3 distributes by multiple row on the external peripheral surface of roller mount 2, and each row needle body 3 is fixedly clamped respectively between adjacent wheel sheet 5; Axial line place in described roller mount 2 offers roller bearing hole 7, by roller bearing 4 by roller mount 2 pivotal mounting on support 6, be convenient to control roller mount 2 by the mode pushed away or draw and roll on human body skin;
The diameter of described each needle body 3 is 0.07～0.35 millimeter, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1～3 millimeter;
Preferred mode is: described a plurality of needle bodies 3 are usually pressed 3～9 column distributions on roller mount 2, and described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2.
This utility model improves and mainly contains following three aspects:
The one, improved the connected mode (see figure 1) of handle 1 and support 6, handle 1 adopts the on-fixed connected modes with the junction 9 of support 6, but handle 1 adopts multi-faceted slip or multi-angle to move embedded mode to carry out activeness with support 6 and be connected; This improvement has solved and has been difficult to the problem that arbitrarily conversion drags angle and direction, has increased handlingly, is easier to use;
The 2nd, in roller mount 2 outsides increases, the 3rd part---protective cover 8(is shown in Fig. 2, Fig. 3, Fig. 5, Fig. 6), this protective cover 8 is installed on support 6, protective cover 8 be that both sides 11 are connected with support 6, bottom surface has a breach 12 and this breach and roller mount 2 on the three-dimensional cover that adapts of needle body 3 extending part sizes; Protective cover 8 is that both sides 11 can be to be fixedly connected with support 6 connected modes, can be also in the situation that needle body 3 length are fixing, according to the requirement of needle body 3 exposed lengths, carries out the packaged type connection, and preferably packaged type connects; This packaged type connection is included on support 6 and presets 2～5 holes, draw-in groove or chute 10, and the both sides 10 of protective cover 8 are connected with hole, draw-in groove or chute 10, preferably 3 holes, draw-in groove or chutes 10; Solve same customer need and use the problem of two or more skin micropin roller devices, reduce customer cost, also reduce the chance that may cause infection;
Part beyond these protective cover 8 bottom surface indentation, there is a plane or curved surface, preferred curved surface, further preferred arc-shaped curved surface; While dragging back and forth skin micropin roller devices, skin creases easily, and uses this protective cover 8, can be before needle body 3 arrives skin, bottom surface by this protective cover 8 first makes skin smooth, solves back and forth the unmanageable problem of dragging speed, makes this utility model device be easier to control;
The 3rd, improve roller mount 2 and needle body 3(and see Fig. 3, Fig. 4), described roller mount 2 is hollow cylinders, no longer comprises a plurality of wheel sheets 5 in the form of annular discs, preferably cylinder; Needle body 3 by solid change into hollow; And each row needle body 3 is fixedly clamped respectively and changes each row needle body 3 into be directly fixed on roller mount 2 between adjacent wheel sheet 5; The material that roller mount 2 is used has elasticity, and when dragging this utility model device, under the pressure dragged, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3.Adopt disposable occupation mode, when this improvement just can solve processing skin, the problem of administration simultaneously or cosmetics, reduced operation sequence and infection chance, is more convenient for using, and is easy to promote.
Improve and introduce with further elaborating of technical scheme and can find out from above population structure, the micropin tourelle is a kind of novel device for purposes such as beauty treatment, administrations, can be used in client or patient's the aspect such as beautifying skin, percutaneous drug delivery, not only simple in structure, easy operation, usage charges are low, and firmly symmetrical stable, but the dragging speed self regulation has reduced the chance infected, use safelyr, having improved can be handling.
(3) technology speciality
This utility model provides a kind of new beautifying skin, the apparatus of percutaneous drug delivery for medical treatment, beauty industry, thereby improve and improve medicine, cosmetics correctly being transported to the systems such as the subcutaneous location that need to treat, particularly percutaneous dosing, Transdermal absorption, slow release.This utility model is safe and effective, and practicality is stronger, and its preparation technology is simple, inexpensive, simple to operate, convenient and swift, through simple training, can grasp, and can be directly used in daily life.
The utility model has the advantages that: the needle roller therapy utilizes the normal healing ability of skin to complete, and can not make the skin hardening or cause the contraction of Skin Cell, and needle roller can be made a large amount of microtubules, is beneficial to directly infiltrate subcutaneous by medicine, nutritional solution etc.Use the rear nursing of needle roller treatment simple and easy, can carry out general outdoor activities, comprise and getting sun.In addition, this skin needle roller can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, because the epidermis wound is small, healing stage is very fast, the probability that is subject to the antibacterial infection also is lowered, application risk is far below the method for traditional removal epidermis in the past, and, except the skin of health and face, also this skin needle roller can be applied to massage skin of head, with blood circulation promoting, stimulate the growth of hair.
Drive needle body by roller mount rolls on the skin of human body, needle body can pierce through skin epidermis and skin corium cell, stimulate the wound self-healing ability of skin corium, thereby chafe, promotion ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be manufactured the epidermal tissue made new advances, thereby reaches the effect of health rejuvenation skin.Use this micropin roller devices, can reach without removing epidermal tissue the effect that makes epidermal tissue's regeneration, and, because the epidermis wound is small, healing stage is very fast, the probability that is subject to the antibacterial infection also is lowered; In addition, it can not make epidermal tissue's attenuation yet, can repeatedly use.This skin needle roller is easy to use, application risk goes the method for epidermis far below tradition, this micropin roller devices can effectively promote the penetration of medicine, cosmetics of skin etc., the effect that medicine, cosmetics etc. pass through skin epidermis and skin corium cell is especially remarkable, is the scientific and technological new technique of the carrying methods such as medicine, cosmetics.Moreover the micropin roller devices stimulates the wound self-healing ability of skin corium, thus chafe, promote the ossein hypertrophy, for the natural reaction to the epidermis tissue injury, dermal tissue can be manufactured the epidermal tissue made new advances, and can make the about percentage eight of thickness hypertrophy of skin epidermis.And the side effect of micropin roller devices technology is extremely low, safe and reliable.
This utility model is studied the apparatus of Transdermal absorption targetedly, and it uses safety, has brought into play to greatest extent effect; Product property is stable, can be suitable for suitability for industrialized production; The successful of Transdermal absorption medicine, cosmetics etc., and the scope of application is wide, therefore is easy to apply, and can have a tremendous social and economic benefits in the short period of time.
This utility model provides a kind of new apparatus source for Transdermal absorption, thus to existing Transdermal absorption product systems particularly the Drug Percutaneous Absorption product carried out improvement, improved, thereby the application of having expanded existing Transdermal absorption product.
This utility model is safe and effective, and practicality is stronger, inexpensive, convenient and swift, and easy, the easy operation of its preparation technology is easy to use, evident in efficacy, can be used for all kinds of Transdermal absorption.
This utility model is studied Transdermal absorption targetedly, has found a kind of new micropin roller devices, and the micropin tourelle has been expanded to new purposes, also, for Transdermal absorption provides a kind of new rule of origin, has made beyond thought achievement; Simultaneously, this utility model is used safety, handling good, the Transdermal absorption successful, brought into play to greatest extent the effect of product, be more suitable for large-scale production and the business application of the industry such as medicine, beauty treatment and industry, can have a tremendous social and economic benefits in the short period of time.
In a word, this utility model active adaption the job demand of modern beauty, medicine and scientific research field and the needs of human nature service, this utility model, for the research and development Transdermal absorption provides new apparatus source, has important value to improving existing Transdermal absorption system.
The accompanying drawing explanation
The schematic diagram that accompanying drawing 1 is this utility model fixed mount;
The schematic diagram that accompanying drawing 2 is this utility model protective cover 8;
Accompanying drawing 3 is the cross section schematic diagram from this utility model roller bearing side;
The schematic diagram that accompanying drawing 4 is this utility model needle roller;
The side design sketch that accompanying drawing 5 is this utility model device;
The bottom surface design sketch that accompanying drawing 6 is this utility model device;
Accompanying drawing 7 is dynamics and depth relationship curve chart;
Accompanying drawing 8, be the experiment effect figure (Franz diffusion cell method) of transdermal administration;
Accompanying drawing 9, be the experimental result picture of matched group;
Accompanying drawing 10, be experimental group (use micropin group) experimental result picture;
In above diagram:
1, hands handle; 2, roller mount; 3, needle body; 4, roller bearing; 6, support; 7, roller bearing hole;
8, protective cover; 9, the junction of handle 1 and support 6; 10, hole, draw-in groove or chute;
11, the both sides 11 of protective cover 8; 12, the breach of protective cover 8 bottom surfaces.
The specific embodiment
This utility model has been studied existing Transdermal absorption device, and a kind of new Transdermal absorption product and structure and purposes are provided, and is convenient to the safe and effective use of the industries such as beauty treatment, medicine.
The micropin roller devices is introduced existing micropin scroll techniques, and its device is transformed, and makes it to possess several functions.This apparatus can be applicable to the Transdermal absorption of beauty parlor, hospital, research institution and uses, and is conducive to improve the transdermal drag delivery system, and application prospect is preferably arranged.
In this utility model, the embodiment of the above-described specific embodiment and the following stated is all in order to set forth better this utility model, is not for limiting the scope of utility model.Below by embodiment, this utility model is described in detail.
This utility model finally need to be prepared into the Transdermal absorption product and be applied, and below will enumerate embodiment and be further described.If you have questions, can contact directly 13386272938 or 15900897066 with the designer.Provide several Transdermal absorption products and using method and some experimental study contents by aforementioned summary of the invention in the above-described specific embodiment and the following example, but should be appreciated that this utility model is not limited in listed research contents herein, should also be appreciated that term as used herein is only for describing specific embodiment, and be not to restriction of the present utility model.
Now, with regard to this utility model device, specifically be described below:
Shown in Fig. 1～4, this utility model relates to a kind of micropin roller devices, it comprises fixed mount, needle roller, 8 three parts of protective cover, and described fixed mount comprises handle 1, the support 6 be flexibly connected with handle 1 by junction 9, the roller bearing 4 be connected with support 6; The embedded mode that described handle 1 adopts multi-faceted slip or multi-angle to move with carry out activeness with support 6 and be connected;
Described needle roller comprises roller mount 2, be arranged at a plurality of needle bodies 3 on the external peripheral surface of roller mount 2, the roller bearing hole 7 of offering at the axial line place of roller mount 2; By roller bearing 4 by roller mount 2 pivotal mounting on support 6;
Described roller mount 2 is hollow cylinders; Needle body 3 is hollow needle body, and each row needle body 3 is directly fixed on roller mount 2, on the external peripheral surface of roller mount 2, by multiple row, distribute, and described each row needle body 3 is 0.07～0.35 millimeter along evenly the arrange diameter of described each needle body 3 of the circumferencial direction of roller mount 2, and the length of exposing at roller mount 2 Outboard Sections of described each needle body 3 is 0.1～0.3 millimeter; Drive needle body by roller mount 2 and roll on the skin of human body, needle body can pierce through the epidermal tissue of skin, and it is caused to small wound, then reaches dermal tissue; The material that roller mount 2 is used has elasticity, and when dragging this utility model device, under the pressure dragged, pharmaceutical liquid or cosmetics liquid can directly directly enter subcutaneous by roller mount 2 by needle body 3; The axial line place of described roller mount 2 offers roller bearing hole 7, in roller bearing hole 7, can insert roller bearing 4, and after being arranged on support 6 by roller bearing 4, roller mount 2 can be rotated around the Pivot Point Center line; Described protective cover 8 is that its bottom surface has the three-dimensional cover that a breach 12 and this breach 12 and needle body 3 extending part sizes on roller mount 2 adapt, and this protective cover 8 is installed on support 6, is that the both sides 11 by its upper end are connected with support 6 movable types; This packaged type connects the preferably connecting portion on support 6 and presets 2～5 holes, draw-in groove or chute 10, and the both sides 11 of protective cover 8 upper ends are connected with hole, draw-in groove or chute 10; It is an arc-shaped curved surface that these protective cover 8 bottom surface breach 12 are sentenced outer part.
After connecting, the rear portion that the operator can hold support 6 has handle 1 and promotes it, support 6 is moved, the roller mount 2 be pivotally connected on support 6 rolls on the skin of human body, thereby extract rapidly after driving the epidermal tissue that needle body 3 pierces through skin, make 3 pairs of epidermises of needle body cause small wound and reach dermal tissue, and for the natural reaction to the epidermis tissue injury, dermal tissue can be manufactured the epidermal tissue made new advances and go to repair these small wounds, thereby reaches effect young, health skin.
This skin needle roller can be applicable to massage health and the facial skin of human body, by needle body 3, utilizes natural method to stimulate the ossein hypertrophy, and can not destroy skin epidermis, thereby promote the regeneration function of skin, reaches cosmetic result; This skin needle roller also can be applicable to massage the skin of head of human body, select the scalp massage of 3 pairs of human bodies of needle body of appropriate diameter, by the epidermal tissue that gives scalp, cause small wound, can promote the blood circulation of scalp, stimulate the growth of hair, to reach the hair caring effect.
Usually in the embodiment adopted at this utility model, described a plurality of needle bodies 3 are by 3～9 column distributions on roller mount 2, and preferably needle body 3 is distributed as 7 row; Described each row needle body 3 is evenly arranged along the circumferencial direction of roller mount 2, be that each individuality in every row needle body 3 is arranged along the circumferencial direction of roller mount 2 equally spacedly, this makes this utility model when application, the epidermal tissue of 3 pairs of skins of needle body causes uniform wound, dermal tissue will produce uniformly new epidermal tissue, thereby can improve cosmetic result.
Utilize the device of technical solutions of the utility model, particular content is as follows:
Table 1, micropin are used dynamics and depth relationship research
After micropin roller transformation, during use, protective cover makes skin smooth, makes to roll easily to carry out, and simultaneously, the diversity that micropin thrusts skin depth under identical dynamics reduces (table 1, Fig. 7), uses easy operating.
The effectiveness of embodiment 2, transdermal administration (Franz diffusion cell method) research
Utilize the device of technical solutions of the utility model, particular content is as follows:
Get 2 nude mice skins, remove subcutaneous tissue, normal saline flushing.Blank group is processed without micropin, and experimental group is processed with transformation micropin roller.Blank group and experimental group skin are fixed in to Franz between coyote hole and receiving chamber, and stratum corneum side is to giving coyote hole, and effectively infiltrating area is 0.85cm
2.To add in receiving chamber water-alcohol solution (isopropyl alcohol: normal saline=1:1) until with skin close contact (4ml), get rid of bubble, be placed in (37.0 ± 0.5) ℃ water bath with thermostatic control, (200 ± 1) r/min constant speed electromagnetic agitation.0.2g tretinoin emulsifiable paste is applied on the Corium Mus horny layer, respectively at 1,2,3,4,5,6,8,10,12h takes out 0.2ml receiving liquid (after getting liquid, supplementing rapidly the water-alcohol solution of equivalent), with HPLC, surveys concentration.Calculate the accumulation infiltration capacity.The lucifuge operation.
Calculate each by accumulation infiltration capacity formula and accumulate infiltration capacity constantly.Formula is:
Wherein: Q is the accumulation infiltration capacity, receiving liquid Chinese medicine concentration when Cn is this sub-sampling, and V is acceptable solution volume in receiving chamber, and Ci is acceptable solution Chinese medicine concentration for for the first time to previous sample the time, and S is i sub-sampling amount.
After using transformation micropin roller, the drug osmotic amount obviously increases, and with experimental group, compares and approximately improves 4 times, sees Fig. 8.
Utilize the device of technical solutions of the utility model, particular content is as follows:
After nude mice anesthesia, with repacking micropin roller, process, after processing, 3d puts to death nude mice, the skin histology of skin administration of learning from else's experience is fixing with 10% formaldehyde (PBS dilution), ethanol dehydration, paraffin embedding, section (5 μ m), put on microscope slide, HE dyeing, under microscope, tissues observed reaction and inflammatory cell situation, take pictures.What without micropin, process is matched group.
The HE dyeing course:
1. hematoxylin dye liquor dyeing 5～15min.
2. flowing water rinses 3～5min.
3. 0.5～1% hydrochloride alcohol solution breaks up the several seconds.
4. flowing water rinses, and weak alkaline aqueous solution shows blue 1min.
5. eosin stain dyeing 10min.
6. washing, the dehydration of ethanol gradient, dimethylbenzene is transparent.
7. mounting, put on the table the absorbent paper of a cleaning, to take out from dimethylbenzene containing the microscope slide of material to be placed on paper and (cut into slices one facing up), promptly in the central authorities of section, drip natural gum (must not carry out again) after the dimethylbenzene drying, hold with the right hand right side that pincet is clamped coverslip lightly, tilt to make a little its left side and envelope to hide agent and contact, and then put down lentamente, avoid producing bubble.
The HE coloration result: matched group (see figure 9) microscope undertissue is normal, uses micropin group (see figure 10) and matched group to organize and do not show inflammatory reaction without significant difference epidermal area and skin corium.
Claims (10)
1. a micropin roller devices, is characterized in that, described this micropin roller devices comprises fixed mount, needle roller, (8) three parts of protective cover;
Described fixed mount comprises handle (1), the support (6) be flexibly connected with handle (1) by junction (9), the roller bearing (4) be connected with support (6);
Described needle roller comprises roller mount (2), be arranged at a plurality of needle bodies (3) on the external peripheral surface of roller mount (2), the roller bearing hole (7) of offering at the axial line place of roller mount (2); By roller bearing (4) by roller mount (2) pivotal mounting on support (6);
Described roller mount (2) is a hollow cylinder, and the material used has elasticity;
Described needle body (3) is hollow needle body, is directly fixed on the external peripheral surface of roller mount (2), by multiple row, distributes;
Described protective cover (8) is that its bottom surface has the three-dimensional cover that needle body (3) the extending part size on a breach (12) and this breach (12) and roller mount (2) adapts, and this protective cover (8) is installed on support (6).
2. micropin roller devices according to claim 1, is characterized in that, described handle (1) and the junction (9) of support (6) are that the embedded mode that adopts multi-faceted slip or multi-angle to move carries out activeness and is connected.
3. micropin roller devices according to claim 1, is characterized in that, described roller mount (2) is a hollow cylinder.
4. micropin roller devices according to claim 1, is characterized in that, described each row needle body (3) is pressed 3～9 column distributions on the external peripheral surface of roller mount (2), and evenly arranges along the circumferencial direction of roller mount (2).
5. micropin roller devices according to claim 1, is characterized in that, the diameter of described each needle body (3) is 0.07～0.35 millimeter, and the length of exposing at roller mount (2) Outboard Sections of described each needle body (3) is 0.1～3 millimeter.
6. micropin roller devices according to claim 1, is characterized in that, the mode that described protective cover (8) is installed on support (6) is that middle part or both sides (11) by its upper end are connected with support (6).
7. micropin roller devices according to claim 6, is characterized in that, the mode that described protective cover (8) is connected with support (6) by its both sides (11) is that packaged type connects.
8. micropin roller devices according to claim 7; it is characterized in that; described protective cover (8) is connected with the packaged type of support (6) junction be included on support (6) by its both sides (11) and presets 2～5 holes, draw-in groove or chutes (10), and the both sides (11) of protective cover (8) are connected with hole, draw-in groove or chute (10).
9. micropin roller devices according to claim 1, is characterized in that, described this protective cover (8) bottom surface indentation, there (12) part in addition is a plane or curved surface.
10. micropin roller devices according to claim 9, is characterized in that, described this protective cover (8) bottom surface indentation, there (12) part in addition is arc-shaped curved surface.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220695917.4U CN203379477U (en) | 2012-12-14 | 2012-12-14 | Micro-needle roller device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201220695917.4U CN203379477U (en) | 2012-12-14 | 2012-12-14 | Micro-needle roller device |
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| CN203379477U true CN203379477U (en) | 2014-01-08 |
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| CN201220695917.4U Expired - Fee Related CN203379477U (en) | 2012-12-14 | 2012-12-14 | Micro-needle roller device |
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| Country | Link |
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| CN (1) | CN203379477U (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103120827A (en) * | 2012-12-14 | 2013-05-29 | 上海市第七人民医院 | Micro-needle roller device |
| US9474685B2 (en) | 2011-09-28 | 2016-10-25 | Sure-Shot Medical Device Inc. | Apparatus for localized dermatological treatment |
| CN106806985A (en) * | 2017-01-19 | 2017-06-09 | 汉典生物科技（上海）有限公司 | A kind of beauty micropin roller |
| US9820954B2 (en) | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
| US11432990B2 (en) | 2013-08-30 | 2022-09-06 | ISOS Solutions, LLC | Textured apparatus with therapeutic material incorporated therein and methods of manufacturing same |
-
2012
- 2012-12-14 CN CN201220695917.4U patent/CN203379477U/en not_active Expired - Fee Related
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9474685B2 (en) | 2011-09-28 | 2016-10-25 | Sure-Shot Medical Device Inc. | Apparatus for localized dermatological treatment |
| CN103120827A (en) * | 2012-12-14 | 2013-05-29 | 上海市第七人民医院 | Micro-needle roller device |
| US11432990B2 (en) | 2013-08-30 | 2022-09-06 | ISOS Solutions, LLC | Textured apparatus with therapeutic material incorporated therein and methods of manufacturing same |
| US9820954B2 (en) | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
| CN106806985A (en) * | 2017-01-19 | 2017-06-09 | 汉典生物科技（上海）有限公司 | A kind of beauty micropin roller |
| CN106806985B (en) * | 2017-01-19 | 2023-03-31 | 汉典生物科技（上海）有限公司 | Cosmetic micropin gyro wheel |
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