CN202626202U - Multifunctional biological reaction constant temperature incubator - Google Patents
Multifunctional biological reaction constant temperature incubator Download PDFInfo
- Publication number
- CN202626202U CN202626202U CN 201220303250 CN201220303250U CN202626202U CN 202626202 U CN202626202 U CN 202626202U CN 201220303250 CN201220303250 CN 201220303250 CN 201220303250 U CN201220303250 U CN 201220303250U CN 202626202 U CN202626202 U CN 202626202U
- Authority
- CN
- China
- Prior art keywords
- casing
- reaction constant
- constant incubator
- drive roll
- platform
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/10—Rotating vessel
- C12M27/12—Roller bottles; Roller tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C12M41/14—Incubators; Climatic chambers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Clinical Laboratory Science (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Analytical Chemistry (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a multifunctional biological reaction constant temperature incubator, which includes a casing and an incubator body, wherein the incubator body is arranged in the casing. The multifunctional biological reaction constant temperature incubator is characterized in that a biological reactor cradle is arranged in the incubator body and includes a platform, an oscillating motor, a drive shaft motor, a driving roller and a driven roller, wherein the platform is hinged inside the incubator body through a rotating shaft; the oscillating motor is connected with the platform through a crankshaft and a connecting rod; the driving roller and the driven shaft are arranged on the upper surface of the platform; the driving shaft is connected with the output shaft of the drive shaft motor; the driven shaft is arranged on one side of the driving shaft in parallel; and the incubator body also includes a pressure roller, and the pressure roller is arranged above the central point of the axis connected line of the driven shaft and the driving shaft. The biological reactor cradle enables the hepatic cells to be uniformly mixed in the biological reactor, thereby being better suitable for the culture of the hepatic cells. The interior of the incubator has balanced temperature and is sterile.
Description
Technical field
The utility model relates to a kind of medicine equipment, particularly a kind of multifunctional bio reaction constant incubator that is used for the biological respinse constant temperature culture.
Background technology
In the prior art, constant incubator is mainly used in the biological respinse that takes place in the bio-reactor is played an auxiliary effect, and like sterilization, maintenance temperature equilibrium etc., like Fig. 3 and shown in Figure 4, prior biological reactor drum 21 main bodys are a tubular mostly.
Along with development of science and technology; The artificial liver technology is more and more ripe; Must carry out biological respinse and on bio-reactor 21 inwalls, carry out hepatocellular cultivation by bio-reactor 21 during the treatment of off-line artificial liver; For liver cell is better grown in bio-reactor 21; Exist two kinds of methods to reach this purpose in the prior art: a kind of is to realize through a kind of funnel type fluidized bed type device, and the bio-reactor that is the basis with the funnel type fluidized bed type device that is loaded with extensive microencapsulated hepatocyte inoculation has good effect to hepatocellular adherent growth; A kind of is through the material in the bio-reactor being stirred the purpose that makes the liver cell adherent growth to reach.Yet these two kinds of method claimed structures are all complicated, and cost of manufacture is also higher relatively.
In addition; The heating unit of existing constant incubator all is arranged on the bottom of incubator; From the bottom to heating in the whole box body; Hot gas flow rises from the bottom and then is full of whole incubator during heating, yet such incubator temperature up and down is different, and it is even to be difficult to reach in the casing constant temperature and temperature; And because the incubator bottom is too high near the heating unit temperature; In case the pipeline of the interior bio-reactor 21 of incubator comes in contact materials such as being easy to cause interior biology of incubator or blood with it and causes damage, and the particular case in the incubator can not be in real time by operator's understanding, in a single day the abnormal conditions operator being taken place in the incubator can not find and take measures in order to avoid result in greater loss timely.
The utility model content
To the deficiency that exists in the prior art, the purpose of the utility model is to provide a kind of multifunctional bio of the adherent growth that the interior liver cell of bio-reactor can be good that makes to react constant incubator.
The technical scheme of the utility model is achieved in that
A kind of multifunctional bio reaction constant incubator comprises shell and casing thermostatically controlled, and said casing is arranged in the said shell; In said casing, be provided with a bio-reactor reel cage; Said bio-reactor reel cage comprises platform, swings motor, drives spindle motor, drive roll and driven roll, and said platform is hinged in the said casing through a rotating shaft, and said swing motor is connected with said platform through a crankshaft-and-connecting-rod; Be provided with drive roll and driven roll at said platform upper surface; Said drive roll is connected with the said output shaft that drives spindle motor, and said driven roll is set in parallel in a side of said drive roll, also comprises a pressure roller that upper-lower position is adjustable; Said pressure roller is arranged on the top of the mid point of said driven roll and said drive roll axle center line, and said pressure roller and said drive roll laterally arrange.
Above-mentioned multifunctional bio reaction constant incubator, said drive roll and said rotating shaft vertical setting each other.
Above-mentioned multifunctional bio reaction constant incubator, said shell is provided with external door, and said casing is provided with inside door and purifying air mouth, and said inside door is over against said external door.
Above-mentioned multifunctional bio reaction constant incubator evenly is equipped with many carbon fibre heating wires on said cabinet exterior, in said casing, be provided with TP, and the place is provided with the air blast disturbing flow device that is used for air disturbance at said purifying air mouth.
Above-mentioned multifunctional bio reaction constant incubator; Also comprise high-voltage electric field air cleaning unit and ultraviolet disinfector; Said high-voltage electric field air cleaning unit is arranged on said purifying air mouth; Said air blast disturbing flow device is arranged on the position over against said air cleaning unit, and said ultraviolet disinfector is arranged on the inside of said casing.
Above-mentioned multifunctional bio reaction constant incubator; Also comprise video monitoring apparatus, said video monitoring apparatus comprises camera and image display, and said camera is arranged in the said casing; Said image display is arranged on the said shell, and said camera is connected with said image display.
Above-mentioned multifunctional bio reaction constant incubator also comprises fire wall, and said fire wall is arranged in the said casing, is distributed with the little mesh of any amount on the said fire wall, and is gapped between said fire wall and the said box body wall.
Above-mentioned multifunctional bio reaction constant incubator, said air blast disturbing flow device is a fan.
Above-mentioned multifunctional bio reaction constant incubator, said TP is connected with said image display.
The beneficial effect of the utility model is: be provided with the bio-reactor reel cage in the multifunctional bio reaction constant incubator and make liver cell better in the inwall adherent growth of bio-reactor; Through the carbon fibre heating wires cabinet exterior is wound up; The feasible thermal balance that adds to casing; The temperature of each several part can raise simultaneously in the casing; The temperature of guaranteeing each several part in the biological respinse incubator can remain unanimity, makes biological respinse incubator internal medium cleanliness factor reach 300,000 grades of purification levels through high-voltage electric field purifying air and disinfection by ultraviolet light sterilization, and good flow-disturbing is arranged so that the inner constant temperature of incubator reaches stable and running balance.
Description of drawings
Fig. 1 is the body structure synoptic diagram of the utility model multifunctional bio reaction constant incubator,
Fig. 2 is the structural representation of the utility model multifunctional bio reaction constant incubator,
Fig. 3 is the bio-reactor reel cage of the utility model multifunctional bio reaction constant incubator and the main TV structure synoptic diagram of bio-reactor,
Fig. 4 is the bio-reactor reel cage of the utility model multifunctional bio reaction constant incubator and the left TV structure synoptic diagram of bio-reactor.
Among the figure: 1-shell, 2-casing, 3-inside door, 4-external door, 5-purifying air mouth, 6-carbon fibre heating wires; The 7-TP, 8-fan, 9-high-voltage electric field air cleaning unit, 10-ultraviolet disinfector, 11-image display, 12-camera; The 13-fire wall, the 14-platform, 15-swings motor, and 16-drives spindle motor, the 17-drive roll; The 18-driven roll, 19-pressure roller, 20-bent axle, 21-bio-reactor, 22-rotating shaft.
Embodiment
Present embodiment is to bioreactor of artificial liver and combine accompanying drawing that the utility model is done further explanation:
As Fig. 1, Fig. 3 and shown in; A kind of multifunctional bio reaction constant incubator; Comprise shell 1 and stainless steel casing 2, said casing 2 is arranged in the said shell 1, in said casing 2, is provided with a bio-reactor reel cage; Said bio-reactor reel cage comprises platform 14, swing motor 15, drives spindle motor 16, drive roll 17, driven roll 18 and pressure roller 19; Said platform 47 is hinged in the said casing 2 through a rotating shaft 22, and said swing motor 15 is connected with said platform 14 with connecting rod through a bent axle 20, is provided with drive roll 17 and driven roll 18 at said platform 14 upper surfaces; Said drive roll 17 and said rotating shaft 22 mutual vertical settings; Said pressure roller 19 is arranged on the top of the mid point of said driven roll 18 and said drive roll 17 axial connecting lines, and said pressure roller 19 laterally arranges with said drive roll 17, for example regulates height that bolt regulates pressure roller 19 with the requirement that adapts to the different diameter bio-reactor with push down bio-reactor 21 downwards through the up-down adjustment device; Said drive roll 17 is connected with the said output shaft that drives spindle motor 16; Said driven roll 18 is set in parallel in a side of said drive roll 17, and drive roll, driven roll and pressure roller can adopt rubber roll, bio-reactor 21 is placed between drive roll 17, the driven roll 18 is held by two rollers; Push down bio-reactor through pressure roller 19 from the top; Bio-reactor 21 and said drive roll 17 axially identical, swing motor 15 output shafts drive bent axle 20 and rotate, and bent axle 20 drives platforms 14 20 swings around the shaft and makes and places the also swing thereupon of bio-reactor 21 on the platform 14; Drive spindle motor 16 output shafts and drive drive roll 17 rotations; Drive roll 17 drives bio-reactor 21 and rotates, and bio-reactor 21 drives driven roll 18 and rotates when rotating, and the pressure roller 19 of bio-reactor 21 tops also rotates along with the rotation of bio-reactor 21; Drive roll 17 and driven roll 18 are in order to carry bio-reactor 21; Pressure roller 19 in order to limit bio-reactor 21 not can because of its with drive roll 17 between mutual motion and come off, it also swings along with swinging up and down of platform 14 at self axial direction due bio-reactor 21 when rolling, so bio-reactor 21 interior liver cells can very good adherent growth.
As depicted in figs. 1 and 2; Said shell 1 is provided with external door 4; Said casing is provided with inside door 3 and purifying air mouth 5, and said inside door 3 evenly is equipped with many carbon fibre heating wires 6 and is used for 2 heating of stainless steel casing over against said external door 4 on said casing 2 outer walls; On casing 2 outer walls, adopt low voltage to organize carbon fibre heating wires 6 is distributed in the mode upper and lower, back, that left and right surfaces is parallelly connected and connects up more; Adopt the low-voltage power supply type of heating, satisfy maximum design temperature and be 65 degrees centigrade constant temperature requirement, make that the temperature in the casing 2 can raise from each surface of casing 2 simultaneously; In said casing 2, be provided with TP 7, realize spatial temperature thermostatically controlled in the casing through TP 7 and unit and carbon fibre heating wires.Be provided with fan 8 at said purifying air mouth 5 places and constitute the air blast disturbing flow device; Utilize in the time of heating and implement air disturbance in 8 pairs of casings of fan 2; Make the temperature of casing 2 interior everywheres can reach balance fast; The distance between two groups of carbon fibre heating wires 6 and the power of fan 8 will keep free temperature to select according to size, warm up time and the institute of casing 2; And on shell 1, be provided with external door 4, be equipped with inside door 3 on the casing 2 and can guarantee further that the temperature in the casing 2 remains on a stable scope.
As shown in Figure 2; Also comprise high-voltage electric field air cleaning unit 9 and ultraviolet disinfector 10; Said high-voltage electric field air cleaning unit 9 is arranged on fan 8 outlets of said air blast disturbing flow device 5; Said fan 8 is arranged on over against the position of said high-voltage electric field air cleaning unit electric field region, and said ultraviolet disinfector 10 is arranged on the inside of said casing 2, air in the electric field of high-voltage electric field air cleaning unit 9 through the time carried out sterilization by high-voltage electric field and purify.Parts such as 10 pairs of casing 2 internal surfaces of ultraviolet disinfector in the casing 2 and bio-reactor and air are further sterilized, and fully guarantee casing 2 interior gnotobasiss.
As depicted in figs. 1 and 2, also comprise video monitoring apparatus, said video monitoring apparatus comprises camera 12 and image display 11; Said camera 12 is arranged in the said casing 2; Be preferably placed at platform 14 top positions, said image display 11 is arranged on the said shell 1, and said camera 12 is connected with said image display 11; Said TP 7 is connected with said image display 11; Monitor the picture in the casing 2 in real time through camera 12, through TP 7 the intravital temperature conditions of case is sent to image display, operator can obtain real-time pictures and the temperature in the casing 2; In case the situation in the casing 2 occur unusual, thereby operator can operate accordingly immediately to deal with problems and avoid causing serious loss.
As shown in Figure 1; Also comprise fire wall 13, be distributed with the little mesh of any amount on the said fire wall 13, said ultraviolet disinfector 10 is installed on the said fire wall 13; Said fire wall 13 will guarantee that with distance between said casing 2 walls gapped dividing plate that makes of dividing plate does not contact with cabinet wall fully; For example equal 1cm, place on bio-reactor 21 culture apparatuses in the casing 2 to have many pipelines, fire wall 13 can effectively solve the pipeline too high problem of thermal radiation closely on 2 pairs of biological respinse culture apparatuses of casing; Can also avoid simultaneously casing 2 inner wall temperatures overload to cause pipeline to contact, damage materials such as biological and blood with casing 2 inwalls.
The foregoing description only is to give an example for what the content that the utility model clearly is described was done, and is not the qualification of the utility model being created embodiment.For the those of ordinary skill in affiliated field, on the basis of above-mentioned explanation, can also make other multi-form variation or change.Here need not also can't give exhaustive to all embodiments.Any conspicuous variation of being extended out within all spirit and principles at the utility model or change still are in the utility model and create among the protection domain of claim.
Claims (10)
1. a multifunctional bio reaction constant incubator comprises shell and casing, and said casing is arranged in the said shell; It is characterized in that, in said casing, be provided with a bio-reactor reel cage, said bio-reactor reel cage comprises platform, swings motor, drives spindle motor, drive roll and driven roll; Said platform is hinged in the said casing through a rotating shaft; Said swing motor is connected with said platform through a crankshaft-and-connecting-rod, is provided with drive roll and driven roll at said platform upper surface, and said drive roll is connected with the said output shaft that drives spindle motor; Said driven roll is set in parallel in a side of said drive roll; Also comprise a pressure roller, said pressure roller is arranged on the top of the mid point of said driven roll and said drive roll axle center line, and said pressure roller and said drive roll laterally arrange.
2. multifunctional bio reaction constant incubator according to claim 1 is characterized in that, said drive roll and said rotating shaft vertical setting each other.
3. multifunctional bio reaction constant incubator according to claim 1 and 2 is characterized in that said drive roll, driven roll and pressure roller are rubber roll.
4. multifunctional bio reaction constant incubator according to claim 1 is characterized in that said shell is provided with external door, and said casing is provided with inside door and purifying air mouth, and said inside door is over against said external door.
5. multifunctional bio reaction constant incubator according to claim 4; It is characterized in that; On said cabinet exterior, evenly be equipped with many carbon fibre heating wires, in said casing, be provided with TP, the place is provided with the air blast disturbing flow device at said purifying air mouth.
6. according to claim 4 or 5 described multifunctional bio reaction constant incubators; It is characterized in that; Also comprise high-voltage electric field air cleaning unit and ultraviolet disinfector; Said high-voltage electric field air cleaning unit is arranged on said purifying air mouth, and said air blast disturbing flow device is arranged on over against the position of said high-voltage electric field air cleaning unit, and said ultraviolet disinfector is arranged on the inside of said casing.
7. multifunctional bio reaction constant incubator according to claim 1; It is characterized in that; Also comprise video monitoring apparatus, said video monitoring apparatus comprises camera and image display, and said camera is arranged in the said casing; Said image display is arranged on the said shell, and said camera is connected with said image display.
8. multifunctional bio reaction constant incubator according to claim 1; It is characterized in that, also comprise fire wall, said fire wall is arranged in the said casing; Be distributed with the little mesh of any amount on the said fire wall, gapped between said fire wall and the said box body wall.
9. multifunctional bio reaction constant incubator according to claim 6 is characterized in that said air blast disturbing flow device is a fan.
10. multifunctional bio reaction constant incubator according to claim 7 is characterized in that said TP is connected with said image display.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220303250 CN202626202U (en) | 2012-06-27 | 2012-06-27 | Multifunctional biological reaction constant temperature incubator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220303250 CN202626202U (en) | 2012-06-27 | 2012-06-27 | Multifunctional biological reaction constant temperature incubator |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202626202U true CN202626202U (en) | 2012-12-26 |
Family
ID=47379421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220303250 Expired - Fee Related CN202626202U (en) | 2012-06-27 | 2012-06-27 | Multifunctional biological reaction constant temperature incubator |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202626202U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103217327A (en) * | 2013-03-28 | 2013-07-24 | 广州安必平医药科技有限公司 | Tissue slice and cell smear sample treating device |
| CN106037941A (en) * | 2016-05-25 | 2016-10-26 | 苏州通快净化科技有限公司 | Thermostatic cabinet box for operating room |
| CN106399097A (en) * | 2016-11-02 | 2017-02-15 | 广东石油化工学院 | Constant-temperature incubator |
-
2012
- 2012-06-27 CN CN 201220303250 patent/CN202626202U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103217327A (en) * | 2013-03-28 | 2013-07-24 | 广州安必平医药科技有限公司 | Tissue slice and cell smear sample treating device |
| CN106037941A (en) * | 2016-05-25 | 2016-10-26 | 苏州通快净化科技有限公司 | Thermostatic cabinet box for operating room |
| CN106399097A (en) * | 2016-11-02 | 2017-02-15 | 广东石油化工学院 | Constant-temperature incubator |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN202626202U (en) | Multifunctional biological reaction constant temperature incubator | |
| CN203938669U (en) | A kind of straw compost helical stir type CO 2generating apparatus | |
| CN209412196U (en) | A kind of lactic acid bacteria Batch Culture device | |
| CN105393803A (en) | Incubator for edible mushrooms | |
| CN107624721A (en) | A kind of intelligent sericultural equipment | |
| CN202945244U (en) | Novel intelligent fermentation tank | |
| CN214572033U (en) | Liver cell culture storage device | |
| CN104193439A (en) | Vertical organic fertilizer fermentation equipment | |
| CN207276602U (en) | A kind of heavy duty detergent bacterial manure installation for fermenting | |
| CN201942676U (en) | Universal multifunctional solid-state fermentation reactor | |
| CN211199244U (en) | Culture solution temperature regulating device for biological cell culture | |
| CN111500433A (en) | Stem cell culture system | |
| CN209162076U (en) | A kind of constant incubator of the Microbiological detection of foods convenient for observation | |
| CN207918856U (en) | A kind of medical Incubators for bacteria culture | |
| CN204022836U (en) | Microbial cultivation device | |
| CN207362244U (en) | A kind of medical inspection microbial culture garden | |
| CN206502818U (en) | A kind of microbial cultivation device | |
| CN108949502A (en) | A kind of installation for fermenting of the biotechnology research and development convenient for adjusting temperature | |
| TW201127953A (en) | Precisely monitoring equipment for beneficial fungi solid state fermentation | |
| CN208964913U (en) | A kind of water isolation type electro-heating standing-temperature cultivator | |
| CN206980603U (en) | A kind of solid material sterilizing is ripening device used | |
| CN207891277U (en) | A kind of microbial-bacterial fertilizer installation for fermenting | |
| CN205258477U (en) | Horizontal microorganism powder culture tank | |
| CN204918570U (en) | Biological fungus liquid fermenting installation | |
| CN202089965U (en) | Novel solid-state fermentation tank |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121226 Termination date: 20150627 |
|
| EXPY | Termination of patent right or utility model |