CN202490463U - Liquid chromatographic separation column capable of being manually assembled - Google Patents
Liquid chromatographic separation column capable of being manually assembled Download PDFInfo
- Publication number
- CN202490463U CN202490463U CN2012201170078U CN201220117007U CN202490463U CN 202490463 U CN202490463 U CN 202490463U CN 2012201170078 U CN2012201170078 U CN 2012201170078U CN 201220117007 U CN201220117007 U CN 201220117007U CN 202490463 U CN202490463 U CN 202490463U
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- cylindrical shell
- convex tendon
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Abstract
The utility model discloses a liquid chromatogram separation column capable of being manually assembled, and the liquid chromatographic separation column comprises a separation column main body and a chromatographic column head, wherein the separation column main body comprises a cylinder, a solid-phase absorptive agent which is filled inside the cylinder, an upper filter plate, a lower filter plate and a dividing separation blade, wherein the upper filter plate and the lower filter plate are respectively sealed on two ends of the solid-phase absorptive agent and are used for preventing the leakage of the solid-phase absorptive agent and for enabling the flowing phase to pass through, the dividing separation blade is arranged on the upper part of the upper filter plate, one end of the cylinder is provided with a liquid outlet, the other end of the cylinder is an opened end, the top of the opened end is provided with a shoulder, the outer side wall of the opened end is provided with an inner circular wall, the chromatographic column head is provided with a liquid inlet, an outer circular wall which is engaged with the inner circular wall in a rotating way and a groove which is matched with the shoulder, and a sealing ring is embedded inside the groove. The liquid chromatographic separation column is simple in structure, convenient and rapid to assemble in a manual way and repeatable to use, the leakage of the flowing phase can be avoided under the large working pressure, and the dropping of the chromatographic column head can be avoided.
Description
Technical field
But the utility model relates to a kind of liquid chromatogram splitter of assembled by hand, belongs to the liquid chromatography technology field.
Background technology
The fast liquid chromatography technology is a kind of quick preparative column chromatography form, and it is based on through pump and produces the elution speed of pressure acceleration flowing phase through the pre-filling type chromatography column, and its core component is the liquid chromatogram splitter.Its separation principle is: blend sample is dissolved in a kind of flowing phase; Make its with certain speed through the fixedly phase adsorbent of can in chromatography column; Because each component of mixture is at the different solubility of mutually fixing and flowing phase; Promptly different at two alternate distribution coefficients, so component of mixture will be crossed fixedly phase adsorbent with different data rate stream, thereby reach the purpose of separation.Yet for a long time, fast liquid chromatography is the glass column filled out of end user's frock always, but this glass column can not withstanding pressure, and danger coefficient is higher during the band press operation, and compares very expensive with plastic column.Chromatograph packing material is of a great variety in the market, and the chromatographic isolation expense cost is high, the customer requirement variation, and based on this a series of market demand, but the market prospects of the liquid chromatogram splitter of assembled by hand are quite wide.But also there is following problem in existing chromatography column on the market in design: 1. structure is complicated, and manufacturing cost and use cost are higher; 2. the chromatogram column cap that flowing phase seepage and chromatography column possibly take place when being with press operation comes off.
United States Patent (USP) 6565745 disclosed chromatography columns have directly been sealed cylindrical shell with the chromatogram column cap, and splitter is become one, and can directly use easily, but the operating pressure that this chromatography column can bear are smaller.The disclosed reusable chromatography column of Chinese patent CN101013116A is realized sealing through the wedge-type seal structure, and its smoothness to the sealing inclined-plane requires high, and any small defective can cause seepage to take place, and causes the splitter production cost higher; This splitter is through being screwed to piercing cap the pressure that provides downward on the cylinder in addition; Promote seal and insert cylinder; But this method is only applicable to the less splitter of diameter; Because along with the increase of splitter diameter, the motive force of seal being inserted cylinder will increase with square ratio, only depend on assembled by hand to be difficult to realize.
Summary of the invention
The purpose of the utility model provides a kind of simple in structure, and assembled by hand is convenient and swift, and is reusable, and under big operating pressure, can not produce the flowing phase seepage, but the liquid chromatogram splitter of the assembled by hand that the chromatogram column cap comes off can not take place yet.
The technical scheme that realizes above-mentioned purpose is: but a kind of liquid chromatogram splitter of assembled by hand; Comprise splitter body and chromatographic column; The splitter body comprises cylindrical shell, fill in cylindrical shell fixedly phase adsorbent be sealed in fixing adsorbent two ends mutually prevent fixing phase adsorbent spill can make also that flowing phase passes through on filter disc and following filter disc and the shunting catch that is positioned over filter disc top; One end of cylindrical shell is provided with liquid outlet; The other end of cylindrical shell is an openend, and the openend top is provided with convex shoulder, and the lateral wall of openend is provided with internal ring wall; Described chromatogram column cap is provided with inlet and rotates the external annulus of engagement and the groove that matches with convex shoulder with internal ring wall, is embedded with sealing ring in the groove.
Further, the outer face that is positioned at inlet of described chromatogram column cap is provided with first and radially strengthens convex tendon and first annular is strengthened convex tendon, and first radially strengthen convex tendon end and inlet join first annular reinforcement convex tendon and the inlet coaxial line.
Further, the outer wall of said chromatogram column cap is provided with the first anti-skidding bar shaped convex tendon.
Further, described inlet and liquid outlet are equipped with lock interface.
Further, the width D of the groove of said chromatogram column cap is slightly larger than the width d of convex shoulder, and the depth H of groove is slightly less than the height h of convex shoulder, and the line footpath M of sealing ring is slightly larger than the depth H of groove, and the internal diameter of sealing ring is slightly less than the internal diameter of groove.
Further, described external annulus is provided with internal thread, and described internal ring wall is provided with the external screw thread that matches with internal thread.
Further, described chromatogram column cap is provided with the first guiding mark, second mark that leads that aligns with the first guiding mark position when described cylindrical shell is provided with screwing hermetic.
Further, the cylindrical shell of internal ring wall lower end is provided with a circle annular convex rib, on the cylindrical shell of the lower end of annular convex rib, is evenly equipped with convex tendon.
Further, the outer face that is positioned at liquid outlet of said cylindrical shell is provided with second and radially strengthens convex tendon and second annular is strengthened convex tendon, and second radially strengthen convex tendon end and liquid outlet join second annular reinforcement convex tendon and the liquid outlet coaxial line.
Further, the inner face that is positioned at liquid outlet of said cylindrical shell is provided with the inner face of annular and strengthens convex tendon, and the width that inner face is strengthened convex tendon is successively decreased to barrel by this inner face, and the other end of inner face reinforcement convex tendon joins with following filter disc.
After adopting technique scheme; The end face of the groove of the chromatogram column cap of the utility model and the end face of convex shoulder are tightly connected through sealing ring crimp; The external annulus of chromatogram column cap and the internal ring wall of cylindrical shell are connected with a joggle through the internal and external threads rotation, and then both form firm seal.When liquid chromatogram is separated the cornice press operation; Because of receiving the influence of back pressure in the cylindrical shell; The chromatogram column cap receives a power that breaks away from cylindrical shell, and the cylindrical shell internal ring wall receives a power that is radially expanded simultaneously, and this power that is radially expanded makes the chromatogram column cap tightr with being connected of cylindrical shell; Further suppress coming off of chromatogram column cap, make the liquid chromatogram splitter can bear higher operating pressure.Simultaneously; The cooperation of convex shoulder and groove and sealing ring; Make that the utility model assembled by hand is more convenient, the utility model is applied to multiple manually or in the fast liquid chromatography piece-rate system of automation as universal splitter, have easy and simple to handle; Use cost is low, can increase substantially advantages such as production efficiency.
Description of drawings
But Fig. 1 is the structural representation of liquid chromatogram splitter of the assembled by hand of the utility model;
Fig. 2 is the A-A cutaway view of Fig. 1;
Fig. 3 is the vertical view of Fig. 1;
Fig. 4 is the upward view of Fig. 1.
The specific embodiment
For the content that makes the utility model is expressly understood more easily, below according to specific embodiment and combine accompanying drawing, the utility model is done further detailed explanation,
Shown in Fig. 1 ~ 4; But a kind of liquid chromatogram splitter of assembled by hand; Comprise splitter body 17 and chromatogram column cap 1; Splitter body 17 comprises cylindrical shell 18, fill in cylindrical shell 18 fixedly phase adsorbent 19 be sealed in fixing adsorbent 19 two ends mutually prevent fixing phase adsorbent 19 spill can make also that flowing phase passes through on filter disc 11 and following filter disc 20 and the shunting catch 10 that is positioned over filter disc 11 tops, an end of cylindrical shell 18 is provided with liquid outlet 24, the other end of cylindrical shell 18 is an openend; The openend top is provided with convex shoulder 7; The lateral wall of openend is provided with internal ring wall 8, chromatogram column cap 1 be provided with inlet 2 and with the external annulus 9 of internal ring wall 8 rotation engagement and with the groove 5 that convex shoulder 7 matches, be embedded with sealing ring 6 in the groove 5.
The outer face that is positioned at inlet 2 of chromatogram column cap 1 is provided with first and radially strengthens convex tendon 3 and first annular is strengthened convex tendon 4, and first radially strengthen convex tendon 3 end and inlet 2 join, first annular is strengthened convex tendon 4 and inlet 2 coaxial lines.
The outer wall of chromatogram column cap 1 is provided with the first anti-skidding bar shaped convex tendon 12.
Inlet 2 is equipped with lock interface with liquid outlet 24.
The width D of the groove 5 of chromatogram column cap 1 is slightly larger than the width d of convex shoulder 7, and the depth H of groove 5 is slightly less than the height h of convex shoulder 7, and the line footpath M of sealing ring 6 is slightly larger than the depth H of groove 5, and the internal diameter of sealing ring 6 is slightly less than the internal diameter of groove 5.
External annulus 9 is provided with internal thread, and described internal ring wall 8 is provided with the external screw thread that matches with internal thread.
Chromatogram column cap 1 is provided with the first guiding mark 13, the second guiding mark 16 that when cylindrical shell 18 is provided with screwing hermetic and the first guiding mark, 13 positions align.
The cylindrical shell 18 of internal ring wall 8 lower ends is provided with a circle annular convex rib 14, on the cylindrical shell of the lower end of annular convex rib 14, is evenly equipped with convex tendon 15.
The outer face that is positioned at liquid outlet 24 of cylindrical shell 18 is provided with second and radially strengthens convex tendon 22 and second annular is strengthened convex tendon 23, and second radially strengthen convex tendon 22 end and liquid outlet 24 join, second annular is strengthened convex tendon 23 and liquid outlet 24 coaxial lines.
The inner face that is positioned at liquid outlet 24 of cylindrical shell 18 is provided with the inner face of annular and strengthens convex tendon 21, and the width that inner face is strengthened convex tendon 21 is successively decreased to cylindrical shell 18 inside by this inner face, and the other end of inner face reinforcement convex tendon 21 joins with following filter disc 20.
The operation principle of the utility model is following:
The end face of the groove 5 of the chromatogram column cap 1 of the utility model and the end face of convex shoulder 7 are tightly connected through sealing ring 6 crimps; The external annulus 9 of chromatogram column cap 1 is connected with a joggle through the internal and external threads rotation with the internal ring wall 8 of cylindrical shell 18, and then both form firm seal.When liquid chromatogram is separated the cornice press operation; Because of receiving the influence of back pressure in the cylindrical shell 18; Chromatogram column cap 1 receives a power that breaks away from cylindrical shell 18, and cylindrical shell 18 internal ring walls 8 receive a power that is radially expanded simultaneously, and this power that is radially expanded makes chromatogram column cap 1 tightr with being connected of cylindrical shell 18; Further suppress coming off of chromatogram column cap 1, make the liquid chromatogram splitter can bear higher operating pressure.Simultaneously; The cooperation of convex shoulder 7 and groove 5 and sealing ring 6; Make that the utility model assembled by hand is more convenient, the utility model is applied to multiple manually or in the fast liquid chromatography piece-rate system of automation as universal splitter, have easy and simple to handle; Use cost is low, can increase substantially advantages such as production efficiency.
Above-described specific embodiment; Purpose, technical scheme and beneficial effect to the utility model have carried out further explain, it should be understood that the above is merely the specific embodiment of the utility model; Be not limited to the utility model; All within the spirit and principle of the utility model, any modification of being made, be equal to replacement, improvement etc., all should be included within the protection domain of the utility model.
Claims (10)
1. but the liquid chromatogram splitter of an assembled by hand; Comprise splitter body (17) and chromatogram column cap (1); Splitter body (17) comprises cylindrical shell (18), fill in cylindrical shell (18) fixedly phase adsorbent (19) be sealed in preventing that fixing phase adsorbent (19) from spilling and also making last filter disc (11) and following filter disc (20) that flowing phase passes through and the shunting catch (10) that is positioned over filter disc (11) top of fixing adsorbent (19) two ends mutually; It is characterized in that: an end of cylindrical shell (18) is provided with liquid outlet (24); The other end of cylindrical shell (18) is an openend; The openend top is provided with convex shoulder (7); The lateral wall of openend is provided with internal ring wall (8), described chromatogram column cap (1) be provided with inlet (2) and with the external annulus (9) of internal ring wall (8) rotation engagement and with the groove (5) that convex shoulder (7) matches, be embedded with sealing ring (6) in the groove (5).
2. but the liquid chromatogram splitter of assembled by hand according to claim 1; It is characterized in that: the outer face that is positioned at inlet (2) of described chromatogram column cap (1) is provided with first and radially strengthens the convex tendon (3) and the first annular reinforcement convex tendon (4); And first radially strengthen convex tendon (3) end and inlet (2) join, first annular is strengthened convex tendon (4) and inlet (2) coaxial line.
3. but the liquid chromatogram splitter of assembled by hand according to claim 1, it is characterized in that: the outer wall of said chromatogram column cap (1) is provided with the first anti-skidding bar shaped convex tendon (12).
4. but the liquid chromatogram splitter of assembled by hand according to claim 1, it is characterized in that: described inlet (2) and liquid outlet (24) are equipped with lock interface.
5. but the liquid chromatogram splitter of assembled by hand according to claim 1; It is characterized in that: the width D of the groove (5) of said chromatogram column cap (1) is slightly larger than the width d of convex shoulder (7); The depth H of groove (5) is slightly less than the height h of convex shoulder (7); The line footpath M of sealing ring (6) is slightly larger than the depth H of groove (5), and the internal diameter of sealing ring (6) is slightly less than the internal diameter of groove (5).
But 6. the liquid chromatogram splitter of assembled by hand according to claim 1, it is characterized in that: described external annulus (9) is provided with internal thread, and described internal ring wall (8) is provided with the external screw thread that matches with internal thread.
7. but the liquid chromatogram splitter of assembled by hand according to claim 1; It is characterized in that: described chromatogram column cap (1) is provided with the first guiding mark (13), the second guiding mark (16) that described cylindrical shell (18) and first guiding mark (13) position when being provided with screwing hermetic aligns.
8. but the liquid chromatogram splitter of assembled by hand according to claim 1; It is characterized in that: the cylindrical shell (18) of internal ring wall (8) lower end is provided with a circle annular convex rib (14), on the cylindrical shell of the lower end of annular convex rib (14), is evenly equipped with convex tendon (15).
9. but the liquid chromatogram splitter of assembled by hand according to claim 1; It is characterized in that: the outer face that is positioned at liquid outlet (24) of said cylindrical shell (18) is provided with second and radially strengthens the convex tendon (22) and the second annular reinforcement convex tendon (23); And second radially strengthen convex tendon (22) end and liquid outlet (24) join, second annular is strengthened convex tendon (23) and liquid outlet (24) coaxial line.
10. but the liquid chromatogram splitter of assembled by hand according to claim 1; It is characterized in that: the inner face that is positioned at liquid outlet (24) of said cylindrical shell (18) is provided with the inner face of annular and strengthens convex tendon (21); The width that inner face is strengthened convex tendon (21) is successively decreased to cylindrical shell (18) inside by this inner face, and the other end of inner face reinforcement convex tendon (21) joins with following filter disc (20).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201170078U CN202490463U (en) | 2012-03-26 | 2012-03-26 | Liquid chromatographic separation column capable of being manually assembled |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012201170078U CN202490463U (en) | 2012-03-26 | 2012-03-26 | Liquid chromatographic separation column capable of being manually assembled |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202490463U true CN202490463U (en) | 2012-10-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012201170078U Expired - Lifetime CN202490463U (en) | 2012-03-26 | 2012-03-26 | Liquid chromatographic separation column capable of being manually assembled |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN202490463U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103752039A (en) * | 2014-01-07 | 2014-04-30 | 南京诺云生物科技有限公司 | Self-supporting modular chromatographic column and application thereof |
| CN111108378A (en) * | 2017-09-01 | 2020-05-05 | 百特基公司 | Chromatography cartridge and method for producing the same |
-
2012
- 2012-03-26 CN CN2012201170078U patent/CN202490463U/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103752039A (en) * | 2014-01-07 | 2014-04-30 | 南京诺云生物科技有限公司 | Self-supporting modular chromatographic column and application thereof |
| CN103752039B (en) * | 2014-01-07 | 2015-09-30 | 南京诺云生物科技有限公司 | Self-supporting modularity chromatographic column and uses thereof |
| CN111108378A (en) * | 2017-09-01 | 2020-05-05 | 百特基公司 | Chromatography cartridge and method for producing the same |
| CN111108378B (en) * | 2017-09-01 | 2022-12-09 | 百特基公司 | Chromatography cartridge and method for producing the same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20121017 |