CN1989090A - 顺式－1,2－取代的二苯乙烯衍生物及其用于制备治疗和/或预防糖尿病的药物的用途 - Google Patents

顺式－1,2－取代的二苯乙烯衍生物及其用于制备治疗和/或预防糖尿病的药物的用途 Download PDF

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CN1989090A
CN1989090A CNA200580024419XA CN200580024419A CN1989090A CN 1989090 A CN1989090 A CN 1989090A CN A200580024419X A CNA200580024419X A CN A200580024419XA CN 200580024419 A CN200580024419 A CN 200580024419A CN 1989090 A CN1989090 A CN 1989090A
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cis
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hydrogen
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CN1989090B (zh
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康志云
吴祖泽
孙庄蓉
唐仲雄
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Institute of Radiation Medicine of CAMMS
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    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
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Abstract

本发明涉及顺式1，2－取代的二苯乙烯衍生物或其药学上可接受的盐、糖苷或溶剂化物，含有所述化合物的药物组合物，以及所述化合物用于制备治疗和/或预防糖尿病或改善糖尿病并发症的药物的用途。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN200580024419XA 2004-07-21 2005-07-20 顺式-1,2-取代的二苯乙烯衍生物及其用于制备治疗和/或预防糖尿病的药物的用途 Expired - Fee Related CN1989090B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN200580024419XA CN1989090B (zh) 2004-07-21 2005-07-20 顺式-1,2-取代的二苯乙烯衍生物及其用于制备治疗和/或预防糖尿病的药物的用途

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN200410069374.5 2004-07-21
CNA2004100693745A CN1723884A (zh) 2004-07-21 2004-07-21 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途
CN200580024419XA CN1989090B (zh) 2004-07-21 2005-07-20 顺式-1,2-取代的二苯乙烯衍生物及其用于制备治疗和/或预防糖尿病的药物的用途
PCT/CN2005/001086 WO2006007794A1 (fr) 2004-07-21 2005-07-20 Derives de stilbene cis-1,2-substitues et utilisation de ceux-ci pour la preparation de medicaments servant au traitement ou a la prevention du diabete

Publications (2)

Publication Number Publication Date
CN1989090A true CN1989090A (zh) 2007-06-27
CN1989090B CN1989090B (zh) 2011-06-01

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CNA2004100693745A Pending CN1723884A (zh) 2004-07-21 2004-07-21 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途
CN200580024419XA Expired - Fee Related CN1989090B (zh) 2004-07-21 2005-07-20 顺式-1,2-取代的二苯乙烯衍生物及其用于制备治疗和/或预防糖尿病的药物的用途

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CNA2004100693745A Pending CN1723884A (zh) 2004-07-21 2004-07-21 顺式－1，2－取代的二苯乙烯衍生物用于制备治疗或预防糖尿病的药物的用途

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US (1) US8039513B2 (zh)
EP (1) EP1801087B1 (zh)
JP (1) JP4991537B2 (zh)
CN (2) CN1723884A (zh)
WO (1) WO2006007794A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
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WO2024061362A1 (zh) * 2022-09-22 2024-03-28 中国科学院上海药物研究所 用于防治血管扩张性疾病的化合物及其制法和用途

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* Cited by examiner, † Cited by third party
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CA2593576C (en) * 2004-01-20 2013-04-23 Brigham Young University Novel sirtuin activating compounds and methods for making the same
CN101450889B (zh) 2007-12-03 2012-05-30 中国科学院理化技术研究所 光催化1,2-二苯乙烯类似物发生顺反异构化反应的方法
EP2519100B1 (en) 2009-12-29 2017-03-15 Mapi Pharma Limited Intermediate compounds and processes for the preparation of tapentadol and related compounds
CN102584805B (zh) * 2011-12-07 2015-04-01 浙江农林大学 天然植物中一个活性成分的制备方法
CN105362282A (zh) * 2015-07-23 2016-03-02 黄冈师范学院 一种治疗糖尿病的活性物质及其制备方法和药物

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US4996237A (en) * 1987-01-06 1991-02-26 Arizona Board Of Regents Combretastatin A-4
US5731353A (en) * 1993-09-08 1998-03-24 Ajinomoto Co., Inc. Stilbene derivatives and pharmaceutical compositions containing them
TW325458B (en) 1993-09-08 1998-01-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions comprising the same for anti-cancer
JPH0959245A (ja) 1995-08-25 1997-03-04 Yamanouchi Pharmaceut Co Ltd Ｎ−（２−プロペノイル）グアニジン誘導体
FR2778337B1 (fr) * 1998-05-05 2001-08-31 Inst Nat Sante Rech Med Antagonistes des ligands du recepteur des arylhydrocarbures
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JP2000256259A (ja) * 1999-03-11 2000-09-19 Nippon Zoki Pharmaceut Co Ltd メイラード反応阻害剤
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CN1224383C (zh) * 1999-11-05 2005-10-26 中国人民解放军军事医学科学院放射医学研究所 一类新型降低血糖化合物
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CN1398838A (zh) 2001-07-26 2003-02-26 中国人民解放军军事医学科学院放射医学研究所 二苯乙烯类化合物制备以及它们在治疗和预防糖尿病中的应用
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024061362A1 (zh) * 2022-09-22 2024-03-28 中国科学院上海药物研究所 用于防治血管扩张性疾病的化合物及其制法和用途

Also Published As

Publication number Publication date
CN1723884A (zh) 2006-01-25
JP2008506722A (ja) 2008-03-06
EP1801087A1 (en) 2007-06-27
CN1989090B (zh) 2011-06-01
JP4991537B2 (ja) 2012-08-01
EP1801087B1 (en) 2012-08-29
US8039513B2 (en) 2011-10-18
EP1801087A4 (en) 2009-09-16
US20090076114A1 (en) 2009-03-19
WO2006007794A1 (fr) 2006-01-26

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