CN1981872B - Puma在肿瘤放化疗增敏中的新用途 - Google Patents
Puma在肿瘤放化疗增敏中的新用途 Download PDFInfo
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- CN1981872B CN1981872B CN 200510130277 CN200510130277A CN1981872B CN 1981872 B CN1981872 B CN 1981872B CN 200510130277 CN200510130277 CN 200510130277 CN 200510130277 A CN200510130277 A CN 200510130277A CN 1981872 B CN1981872 B CN 1981872B
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Title |
---|
代文杰等.肝细胞基因转导载体***应用进展.中国普外基础与临床杂志9 1.2002,9(1),58-60. |
代文杰等.肝细胞基因转导载体***应用进展.中国普外基础与临床杂志9 1.2002,9(1),58-60. * |
曹冬炎等.耐药性卵巢癌的治疗.中国医刊 11.2005,(11),23-25. |
曹冬炎等.耐药性卵巢癌的治疗.中国医刊 11.2005,(11),23-25. * |
赵小平等.Bcl-2家族中唯BH3域蛋白的研究进展.生命科学17 5.2005,17(5),413页,第1栏,33-43行. |
赵小平等.Bcl-2家族中唯BH3域蛋白的研究进展.生命科学17 5.2005,17(5),413页,第1栏,33-43行. * |
郝延璋等.Puma/ Bbc3在细胞凋亡中的作用及其机制.医学分子生物学杂志1 6.2004,1(6),366-369. |
郝延璋等.Puma/ Bbc3在细胞凋亡中的作用及其机制.医学分子生物学杂志1 6.2004,1(6),366-369. * |
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