CN1973669A - Feed additive capable of inhibiting urease activity and its prepn - Google Patents
Feed additive capable of inhibiting urease activity and its prepn Download PDFInfo
- Publication number
- CN1973669A CN1973669A CNA2006101550659A CN200610155065A CN1973669A CN 1973669 A CN1973669 A CN 1973669A CN A2006101550659 A CNA2006101550659 A CN A2006101550659A CN 200610155065 A CN200610155065 A CN 200610155065A CN 1973669 A CN1973669 A CN 1973669A
- Authority
- CN
- China
- Prior art keywords
- wall material
- urease activity
- feed addictive
- gelatin
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000694 effects Effects 0.000 title claims abstract description 35
- 108010046334 Urease Proteins 0.000 title claims abstract description 33
- 239000003674 animal food additive Substances 0.000 title abstract description 4
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 239000000463 material Substances 0.000 claims abstract description 97
- 239000007788 liquid Substances 0.000 claims abstract description 36
- 108010010803 Gelatin Proteins 0.000 claims abstract description 19
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 19
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 19
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 19
- 239000008273 gelatin Substances 0.000 claims abstract description 19
- 229920000159 gelatin Polymers 0.000 claims abstract description 19
- 235000019322 gelatine Nutrition 0.000 claims abstract description 19
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 19
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 19
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 19
- 239000007787 solid Substances 0.000 claims abstract description 17
- 238000003756 stirring Methods 0.000 claims abstract description 17
- 229940090496 Urease inhibitor Drugs 0.000 claims abstract description 8
- 239000002601 urease inhibitor Substances 0.000 claims abstract description 8
- 239000000203 mixture Substances 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 3
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 claims description 22
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 22
- 229930016911 cinnamic acid Natural products 0.000 claims description 22
- 235000013985 cinnamic acid Nutrition 0.000 claims description 22
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 22
- 240000002234 Allium sativum Species 0.000 claims description 21
- 235000004611 garlic Nutrition 0.000 claims description 21
- WHGYBXFWUBPSRW-UHFFFAOYSA-N Cycloheptaamylose Natural products O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO WHGYBXFWUBPSRW-UHFFFAOYSA-N 0.000 claims description 18
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 18
- 239000008158 vegetable oil Substances 0.000 claims description 18
- 230000018044 dehydration Effects 0.000 claims description 16
- 238000006297 dehydration reaction Methods 0.000 claims description 16
- 238000000265 homogenisation Methods 0.000 claims description 16
- 241000196324 Embryophyta Species 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract description 8
- 241001465754 Metazoa Species 0.000 abstract description 4
- 229910021529 ammonia Inorganic materials 0.000 abstract description 4
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- 239000001116 FEMA 4028 Substances 0.000 abstract 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 238000009395 breeding Methods 0.000 abstract 1
- 230000001488 breeding effect Effects 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000011162 core material Substances 0.000 abstract 1
- 238000003912 environmental pollution Methods 0.000 abstract 1
- 239000007789 gas Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 239000007921 spray Substances 0.000 description 20
- 239000000047 product Substances 0.000 description 17
- 230000005764 inhibitory process Effects 0.000 description 15
- 239000007864 aqueous solution Substances 0.000 description 14
- 238000001035 drying Methods 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 238000009360 aquaculture Methods 0.000 description 6
- 244000144974 aquaculture Species 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000010630 cinnamon oil Substances 0.000 description 4
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000010081 allicin Nutrition 0.000 description 3
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- -1 di(2-ethylhexyl)phosphate acid amides Chemical class 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 description 1
- 241000522254 Cassia Species 0.000 description 1
- 206010059410 Faecaluria Diseases 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- YSMRWXYRXBRSND-UHFFFAOYSA-N TOTP Chemical compound CC1=CC=CC=C1OP(=O)(OC=1C(=CC=CC=1)C)OC1=CC=CC=C1C YSMRWXYRXBRSND-UHFFFAOYSA-N 0.000 description 1
- RRUDCFGSUDOHDG-UHFFFAOYSA-N acetohydroxamic acid Chemical compound CC(O)=NO RRUDCFGSUDOHDG-UHFFFAOYSA-N 0.000 description 1
- 229960001171 acetohydroxamic acid Drugs 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000004054 benzoquinones Chemical class 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fodder In General (AREA)
Abstract
The present invention discloses one kind of feed additive capable of inhibiting urease activity and its preparation process. The preparation process includes compounding wall material solution with beta-cyclodextrin, gelatin and/or sodium carboxymethyl cellulose, adding urease inhibitor as core material while stirring to form mixture liquid with solid content of 15-20 %; heating the mixture to 60-65 deg.c and homogenizing at high pressure of 35-40 MPa to form homogeneous stable material liquid; spray drying the material liquid at material feeding temperature of 60-65 deg.c, air intake temperature of 170-180 deg.c, air outlet temperature of 80-90 deg.c, nozzle diameter of 0.15 mm and nozzle pressure of 1.8x10<5> Pa. The feed additive can inhibit activity of urease, reduce exhausted ammonia and other bad smell gases, raise the producibility of animal and reduce the environmental pollution caused by livestock breeding.
Description
Technical field
The present invention relates to a kind of feed addictive that suppresses urease activity and preparation method thereof.
Background technology
Along with the continuous development of aquaculture, fecaluria and foul smell that aquaculture produces are also more and more serious to the influence of environment.For reducing the negative effect that aquaculture is brought, the research that reduces foul smell dischargings such as ammonia by various means has become home and abroad environment nutrition scholar's research focus.But the efficient of the urease inhibitor (as di(2-ethylhexyl)phosphate acid amides, tricresyl phosphate acid amides, tricresyl phosphate acid amides benzene, phosphoric acid ring triamide, hydroxamic acid and derivative acetohydroxamic acid thereof, xenol, benzoquinones etc.) that present domestic research is more is not high, and some also has very big harm to human body or environment.Thereby, highly effective and safe, there is the deodorant of the plant type that enriches plant origin to have good market prospects certainly in China.But the active component in the plant is often effective, active strong, there is smell unstable or that have some animals to dislike simultaneously, effect is unsatisfactory in actual applications, the invention provides a kind of plant type deodorization feed additive of efficient inhibition urease activity, the active component that extracts in the plant has been carried out the bag quilt, it can obviously suppress urease activity, increase the amount retained of total nitrogen in the slurry of feces and urine, foul smell such as minimizing ammonia are to the discharging of environment, improve and culture air quality, improve the production performance of animal.Its Application and Development can obviously reduce the aquaculture pollution on the environment, promotes the sustainable development of aquaculture.
The reference technology that allicin extracts: the garlic peeling is cleaned and is smashed into mashed garlic to pieces, mashed garlic is at 40 ℃ of water-bath 0.5h, press solid-liquid ratio lg: 4ml and add volume fraction 95% ethanol extraction 1.5h under 30 ℃, control vapo(u)rizing temperature then at 50 ℃, pressure is at 0.01MPa, the Rotary Evaporators rotating speed reduces pressure concentrated at 75r/s, obtain allicin (Ceng Zheling etc. 2006).
Cinnamon oil extracts the reference technology separate with cinnamic acid: get three mouthfuls of round-bottomed flasks that Chinese cassia tree 200g after the pulverizing places 5000ml, add 2L distilled water, soak 1～2h, press (appendix XD) extraction of Pharmacopoeia of the People's Republic of China version in 2000 cinnamon oil.Then the 5ml cinnamon oil is mixed with the saturated solution of sodium bisulfite of 15ml, behind the shake well 1h, have addition product to separate out, suction filtration, the absolute ether that filtrate was heavily steamed with equivalent extracts 4 times, and each 10min obtains unreacted oil.Addition product adds 0.1mol/L NaOH to all dissolvings, and the absolute ether extraction of heavily steaming with equivalent 4 times obtains comparatively pure cinnamic acid and corresponding derivative (Zhou Feng etc. 2006) thereof after boiling off ether.Above-mentioned in the present invention comparatively pure cinnamic acid that obtains and corresponding derivative thereof promptly are considered as cinnamic acid.
List of references:
Ceng Zheling etc., the Study on extraction of allicin, food and fermentation industries, 2006 (2): 121-123. Zhou Feng etc., cinnamon oil extracts active ingredients, purifying and identification research, Food Science, 2006 (4): 59-61.
Summary of the invention
The invention provides a kind of feed addictive that suppresses urease activity and preparation method thereof.
Suppress the feed addictive of urease activity and be made up of core and wall material, core is a urease inhibitor, and the wall material is one or more mixtures in cycloheptaamylose, gelatin and three kinds of materials of sodium carboxymethylcellulose.
Described urease inhibitor is the cinnamic acid that extracts from plant respectively and the mixture of garlic vegetable oil, and wherein the proportioning of cinnamic acid and garlic vegetable oil is 1: 0.01～1.The cycloheptaamylose in the wall material and the portfolio ratio of gelatin are: 1: 0.05-0.5.The portfolio ratio of cycloheptaamylose and sodium carboxymethylcellulose is: 1: 0.1-10.The portfolio ratio of gelatin and sodium carboxymethylcellulose is: 1: 0.01-1.The portfolio ratio of cycloheptaamylose, gelatin and sodium carboxymethylcellulose is: 1: 0.05-0.5: 0.1-1.
The preparation method who suppresses the feed addictive of urease activity: with one or more mixing in cycloheptaamylose, gelatin and three kinds of materials of sodium carboxymethylcellulose, be made into wall material solution, add the urease inhibitor core while stirring, make core and wall material than 1ml: 8～10g, the mixed liquor solid content is 15～20%.Mixed material heated carry out high-pressure homogeneously to 60～65 ℃, homogenization pressure 35～40MPa forms uniform and stable material liquid behind the homogeneous.With the material liquid dehydration that atomizes in spray drying tower, operational factor is: 60～65 ℃ of feeding temperatures, 170～180 ℃ of EATs, 80～90 ℃ of leaving air temps, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.
The present invention can obviously suppress urease activity, increases the amount retained of total nitrogen in the slurry of feces and urine, and foul smell such as minimizing ammonia improve and culture air quality to the discharging of environment, obviously improve the production performance of animal, obviously reduce the aquaculture pollution on the environment.Feed addictive of the present invention is Powdered, various composition stable performance, easy to use, safe in utilization for a long time, pollution-free, noresidue, has no side effect.Constant product quality is fit to modernization industry and produces.Have remarkable economic efficiency and social benefit.
The specific embodiment
The feed addictive that suppresses urease activity is Powdered, is that the compound with this powdery adds in mixed feed, concentrated feed or the premixed feed during application, and evenly mixes, and its addition is amounted in the mixed feed content and counted 0.1～0.5%.
Embodiment 1:
Cycloheptaamylose is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 8g, the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.With material liquid atomizing dehydration in the small-sized spray dance of B CHI Mini Spray Dryer B-191 drying machine, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 25ml/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 2:
Cycloheptaamylose is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 10g, the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-150 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 170kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 3:
Gelatin is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 8g, the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.With material liquid atomizing dehydration in the small-sized spray dance of B CHI Mini Spray Dryer B-191 drying machine, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 25ml/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 4:
Gelatin is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 10g, the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 65 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-50 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 170kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 5:
Sodium carboxymethylcellulose is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 10g, the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 65 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-150 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 170kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 6:
Sodium carboxymethylcellulose is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 8g, the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.With material liquid atomizing dehydration in the small-sized spray dance of B CHI Mini Spray Dryer B-191 drying machine, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 25ml/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 7:
Cycloheptaamylose is mixed in 1: 0.05 ratio with gelatin, be made into the wall material aqueous solution, add while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 8g, the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 65 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.With material liquid atomizing dehydration in the small-sized spray dance of B CHI Mini Spray Dryer B-191 drying machine, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 25ml/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 8:
Cycloheptaamylose is mixed in 1: 0.5 ratio with gelatin, be made into the wall material aqueous solution, add while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 10g, the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-50 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 170kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 9:
Sodium carboxymethylcellulose is mixed with cycloheptaamylose, mixed proportion is 0.1: 1, is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 8g, the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in medium-sized drying machine with centrifugal spray LPG-25 type, atomizes, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 20kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 10:
Sodium carboxymethylcellulose is mixed with cycloheptaamylose, and mixed proportion is 10: 1, is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, makes core and wall material than 1ml: 10g, and the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 65 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-50 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 60kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 11:
Sodium carboxymethylcellulose is mixed with gelatin, and mixed proportion is 0.01: 1, is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, makes core and wall material than 1ml: 8g, and the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.With material liquid atomizing dehydration in the small-sized spray dance of B CHI Mini Spray Dryer B-191 drying machine, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 25ml/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 12:
Sodium carboxymethylcellulose is mixed with gelatin, and mixed proportion is 1: 1, is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, makes core and wall material than 1ml: 10g, and the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 60 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-50 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 60kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 13:
Sodium carboxymethylcellulose is mixed with cycloheptaamylose, gelatin, mixed proportion is 0.1: 1: 0.05, is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 0.01 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 8g, the mixed liquor solid content is 15%.Mixed material heated carry out high-pressure homogeneously to 65 ℃, homogenization pressure 35MPa forms uniform and stable material liquid behind the homogeneous.With material liquid atomizing dehydration in the small-sized spray dance of B CHI Mini Spray Dryer B-191 drying machine, operational factor: 170 ℃ of EATs, 80 ℃ of leaving air temps, charging rate 25ml/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Embodiment 14:
Sodium carboxymethylcellulose is mixed with cycloheptaamylose, gelatin, mixed proportion is 1: 1: 0.5, is made into the wall material aqueous solution, adds while stirring by the cinnamic acid of 1: 1 proportioning and the core of garlic vegetable oil, make core and wall material than 1ml: 10g, the mixed liquor solid content is 20%.Mixed material heated carry out high-pressure homogeneously to 65 ℃, homogenization pressure 40MPa forms uniform and stable material liquid behind the homogeneous.The material liquid dehydration that in large centrifugal spray dryer LPG-50 type, atomizes, operational factor: 180 ℃ of EATs, 90 ℃ of leaving air temps, charging rate 60kg/h, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.Spray-dired product is a kind of feed addictive of efficient inhibition urease activity.
Claims (7)
1. feed addictive that suppresses urease activity, it is characterized in that: be made up of core and wall material, core is a urease inhibitor, the wall material is one or more mixtures in cycloheptaamylose, gelatin and three kinds of materials of sodium carboxymethylcellulose.
2. a kind of feed addictive that suppresses urease activity according to claim 1, it is characterized in that: described urease inhibitor is the cinnamic acid that extracts from plant respectively and the mixture of garlic vegetable oil, and wherein the proportioning of cinnamic acid and garlic vegetable oil is 1: 0.01～1.
3. a kind of feed addictive that suppresses urease activity according to claim 1 is characterized in that: the cycloheptaamylose in the described wall material and the portfolio ratio of gelatin are: 1: 0.05-0.5.
4. a kind of feed addictive that suppresses urease activity according to claim 1 is characterized in that: the cycloheptaamylose in the described wall material and the portfolio ratio of sodium carboxymethylcellulose are: 1: 0.1-10.
5. a kind of feed addictive that suppresses urease activity according to claim 1 is characterized in that: the portfolio ratio that described wall material is gelatin and sodium carboxymethylcellulose is: 1: 0.01-1.
6. a kind of feed addictive that suppresses urease activity according to claim 1 is characterized in that: the portfolio ratio of cycloheptaamylose, gelatin and sodium carboxymethylcellulose in the described wall material is: 1: 0.05-0.5: 0.1-1.
7. preparation method who suppresses the feed addictive of urease activity according to claim 1, it is characterized in that: with one or more mixing in cycloheptaamylose, gelatin and three kinds of materials of sodium carboxymethylcellulose, be made into wall material solution, add the urease inhibitor core while stirring, make core and wall material than 1ml: 8～10g, the mixed liquor solid content is 15～20%.Mixed material heated carry out high-pressure homogeneously to 60～65 ℃, homogenization pressure 35～40MPa forms uniform and stable material liquid behind the homogeneous.With the material liquid dehydration that atomizes in spray drying tower, operational factor is: 60～65 ℃ of feeding temperatures, 170～180 ℃ of EATs, 80～90 ℃ of leaving air temps, nozzle diameter 0.15mm, nozzle exit pressure 1.8 * 10
5Pa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101550659A CN100444745C (en) | 2006-12-07 | 2006-12-07 | Feed additive capable of inhibiting urease activity and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101550659A CN100444745C (en) | 2006-12-07 | 2006-12-07 | Feed additive capable of inhibiting urease activity and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1973669A true CN1973669A (en) | 2007-06-06 |
| CN100444745C CN100444745C (en) | 2008-12-24 |
Family
ID=38124236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101550659A Expired - Fee Related CN100444745C (en) | 2006-12-07 | 2006-12-07 | Feed additive capable of inhibiting urease activity and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100444745C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171690A (en) * | 2014-08-06 | 2014-12-03 | 广州市信农生物科技有限公司 | Feed additive used for repelling mosquitoes and removing odor of pigsty |
| CN109534936A (en) * | 2018-12-29 | 2019-03-29 | 河南心连心化肥有限公司 | A kind of multiple slow-release stable urea of high dispersive, process units and production technology |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1210853A (en) * | 1997-05-16 | 1999-03-17 | 中国农业科学院畜牧研究所 | Synthesis and use of rumen microorganism urease inhibitor |
| CN1164266C (en) * | 2001-09-29 | 2004-09-01 | 东北农业大学 | Special inhibitor for ruminant urease |
-
2006
- 2006-12-07 CN CNB2006101550659A patent/CN100444745C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104171690A (en) * | 2014-08-06 | 2014-12-03 | 广州市信农生物科技有限公司 | Feed additive used for repelling mosquitoes and removing odor of pigsty |
| CN109534936A (en) * | 2018-12-29 | 2019-03-29 | 河南心连心化肥有限公司 | A kind of multiple slow-release stable urea of high dispersive, process units and production technology |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100444745C (en) | 2008-12-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2015090204A1 (en) | Method for producing biological feed additive using cassava residue and ethanol waste mash | |
| CN101928159B (en) | Method for producing organic fertilizer by using water hyacinth | |
| CN105777437A (en) | Preparing method for high-activity humic acid bio-fertilizer | |
| CN111345402A (en) | Functional additive and preparation method and application thereof | |
| WO2015090205A1 (en) | Method for producing biological feed additive by utilizing cassava residue and alcohol waste mash | |
| CN106343182A (en) | Feed additive for reducing nitrogen excretion of ruminants and preparation method of feed additive | |
| CN103651269A (en) | Method for breeding earthworms with Chinese medicine residues | |
| CN101611762B (en) | Compound quick-action inhibitor against generation of methane and preparation method and application thereof | |
| CN112568328A (en) | Enteric coated nano zinc oxide particle and production method thereof | |
| CN104119110A (en) | Production method for vinasse bio-organic fertilizer | |
| CN100444745C (en) | Feed additive capable of inhibiting urease activity and its prepn | |
| CN102295475A (en) | Organic fertilizer prepared from solid and liquid products obtained by gasification of biomass and preparation method thereof | |
| CN101524112A (en) | Circulation process of environment-friendly treatment system of feces and the like waste in breeding farm | |
| CN101530166A (en) | Organic iron feedstuff additive and preparing method and use thereof | |
| CN106866194A (en) | Biogas slurry organic fertilizer and preparation method thereof | |
| FI118596B (en) | Method for treating biomass | |
| CN109320129A (en) | A kind of lignocellulose type cement grinding aid and preparation method thereof | |
| CN106995788A (en) | A kind of complex microorganism preparations and preparation method and application for decomposing human feces | |
| CN102815975A (en) | Novel ecological preparation for resource utilization of municipal refuse | |
| CN103892045A (en) | Livestock and poultry feed produced by sophora japonica solid dregs, and preparation method thereof | |
| CN1672738A (en) | Deodorizing additive of compound plant extract for farm animal and its use | |
| CN102224888B (en) | Calf fodder and its preparation method | |
| KR20150055998A (en) | Feed and Feed additives for reducing bad odor of excretion | |
| CN208327868U (en) | A kind of system that cow dung prepares soil conditioner | |
| CN107778102A (en) | A kind of preparation method of chicken manure fertilizer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081224 Termination date: 20151207 |
|
| EXPY | Termination of patent right or utility model |