CN1960701A - 使用吸收性织物的口腔护理方法 - Google Patents
使用吸收性织物的口腔护理方法 Download PDFInfo
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- CN1960701A CN1960701A CNA2005800171663A CN200580017166A CN1960701A CN 1960701 A CN1960701 A CN 1960701A CN A2005800171663 A CNA2005800171663 A CN A2005800171663A CN 200580017166 A CN200580017166 A CN 200580017166A CN 1960701 A CN1960701 A CN 1960701A
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- oral cavity
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- A—HUMAN NECESSITIES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
Landscapes
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Abstract
一种提高口腔护理剂效力的方法,该方法包括通过用吸收性织物擦拭表面来预处理口腔表面,该吸收性织物中已浸渍或其上涂覆口腔可接受的预处理剂,例如口腔护理剂的活化剂,其中所述擦拭将活化有效量的预处理剂从所述织物转移至口腔表面,其后将包含口腔护理剂的组合物施用于口腔表面。
Description
发明领域
[0001]本发明涉及口腔护理方法,更具体地说涉及牙齿表面护理的方法。
发明背景
[0002]某些用于口腔护理的药剂,例如用于清洁、增白和保护牙齿的药剂,当在活化剂的存在下起作用时,性能显示出提高。作为实例,过氧化合物使牙齿表面增白的效力可在某些活化剂,例如锰配位络合化合物及铁和铜盐的存在下提高。过氧化合物的另一类活化剂是碱化剂,典型地为碱性化合物例如碳酸盐或碳酸氢盐,众所周知在更高的pH下促进从过氧化合物例如过氧化氢中释放氧。作为再一个实例,用于通过在口腔中泡腾提供清洁口感和/或其他益处的碳酸氢盐,其作用可在酸化剂的存在下提高,该酸化剂加速该泡腾。作为还再一个实例,在钙盐和/或酸化剂的存在下,可促进可溶性氟化物来源例如氟化钠的氟离子加入至牙釉质中。
[0003]在这些和其他情况中,口腔护理剂与活化剂的过早相互作用可导致效力的部分或全部丧失。例如,如果为了储存于碱性介质中而配制过氧化合物,其作为增白剂的效力可由于氧的过早释放而降低。类似地,将碳酸氢钠在使用前暴露于酸性介质中导致二氧化碳的过早释放,并且当置于口腔时丧失了泡腾剂的功效。氟化钠与钙盐的共配制导致不溶性氟化钙的形成,及在储存一段时期后施用于牙齿时,结果是供摄取氟离子的利用度降低。
[0004]向口腔释放口腔护理剂和活化剂的努力包括以两组分产品同时释放此类药剂,其中这些药剂保持独立直到导入口中或在此之前不久。
[0005]例如,Gaffar&Fakhry-Smith的美国专利No.5,648,064中公开了两种组分的增白洁齿剂组合物,其中一种组分包含过氧化合物,而另一种包含锰配位络合物例如葡萄糖酸锰。维持此两种组分相互独立,直到调剂使用。
[0006]Hoic等的美国专利No.6,254,857中公开了两种组分的增白洁齿剂组合物,其中一种组分包含过氧化合物,而另一种包含铁盐和铜盐的混合物。维持此两种组分相互独立,直到调剂使用。
[0007]Banerjee&Friedman的美国专利申请公布No.2002/0141949中提出用敷料器,例如具有其中以干燥形式储存的活化剂(例如二氯化锰、柠檬酸锰、硫酸亚铁、碳酸钠、碳酸氢钠或催化酶)的牙刷将包含过氧化物漂白剂的凝胶施用到牙齿表面。
[0008]欧洲专利No.0897714中公开了两种组分的漱口剂产品,其中一种组分包含过氧化氢的水溶液(pH<4.5),而另一种包含缓冲盐的水溶液或水/醇溶液(pH>8)。此两种组分在使用前混合。
[0009]Pellico的美国专利No.5,928,628中公开了适用于从牙齿漂白用盘施用于牙齿的两种组分的漂白***。一种组分包含具有pH约4至约7的过氧化物凝胶,而另一种包含具有pH约9至约13的碱性凝胶。此两种组分在使用前混合。
[0010]Kiozpeoplou的美国专利No.4,487,757中提出,在牙膏容器的分离部分将牙膏分离成两部分,一部分包含稳定化的碱金属碳酸氢盐,而另一部分包含与该碳酸氢盐反应的酸或酸盐。该牙膏据称在刷牙时,此两部分充分混合期间剧烈地起泡。
[0011]Clarkson等的美国专利No.5,045,305中描述了一种包含两种分离的牙膏或漱口剂组分的口腔护理产品,一种组分包含氟化钠,而另一种包含氯化钙。此类组分在被导入到口中前混合。
[0012]Joziak等的美国专利No.6,346,235中公开了使用两种组分洁齿剂提高氟化物利用度的方法,其中一种组分包含在碱性环境中的氟化钠,而另一种包含在酸性环境中的磷酸盐离子源。
[0013]与上述公开相比,Curtis等的美国专利No.6,174,516中公开了一种连续处理方法。根据该’516专利,首先将具有碱性pH的水性清洗组合物施用于牙齿,其后用过氧化物洁齿剂刷牙。
[0014]Copelan&Copelan的美国专利No.5,133,971中公开了一种其中浸渍脱水组合物的膜,例如非织造纤维素纤维垫,该组合物包含用于牙齿卫生的药剂例如碳酸氢钠的组合。
[0015]上述专利及公布通过引用结合到本文中。
[0016]在本领域中对通过口腔护理剂与活化剂的相互作用,在口腔中活化口腔护理剂的替代方法仍有需求。
发明概要
[0017]现在,提供提高口腔护理剂效力的方法,该方法包括通过用吸收性织物擦拭表面来预处理口腔表面,该织物中已浸渍或其上涂覆口腔可接受的预处理剂,其中该擦拭将有效量的预处理剂从该织物转移到口腔表面,然后将包含口腔护理剂的组合物施用于口腔表面。
[0018]根据本发明的实施方案,该预处理剂为口腔护理剂的活化剂,该擦拭将活化有效量的活化剂从织物转移到口腔表面。
[0019]在特定的实施方案中,提供了使牙齿表面增白的方法,该方法包括用吸收性织物擦拭表面,该织物中已浸渍或其上涂覆口腔可接受的碱化剂,然后将包含口腔可接受的过氧化合物的组合物施用于该表面。
[0020]还提供了用于实施本发明方法的药剂盒。该药剂盒包括(a)包含口腔护理剂的组合物,和(b)吸收性织物,其中已浸渍或其上涂覆口腔可接受的预处理剂,例如口腔护理剂的活化剂。在特定的实施方案中,该药剂盒包括(a)包含口腔可接受的过氧化合物的组合物,和(b)吸收性织物,其中已浸渍或其上涂覆口腔可接受的碱化剂。
[0021]本发明的再一个实施方案为用于将增白处理的牙齿表面预处理的物品,该物品包括润湿拭巾(towelette),该拭巾载有有效量的口腔可接受碱化剂水溶液,当用该拭巾擦拭表面时,该有效量在牙齿表面提供至少约7的pH。
发明详述
[0022]“口腔护理”剂在本文中为在增进口腔卫生或在使口腔表面美容提高方面,用于口腔疾病、障碍或不需要病症的局部治疗或预防的药剂。此类药剂通常可施用于口腔的内部,或施用于其特定的部位,例如舌、腭、颊粘膜、牙齿和/或龈。
[0023]“口腔表面”在本文中包括口腔内的任何软表面或硬表面,包括舌、硬腭和软腭、颊粘膜、龈和牙齿表面的表面。
[0024]“牙齿表面”在本文中为自然牙齿的表面,或包括牙冠、牙髓盖、填料、桥、托牙、牙植入物等的人造牙列的硬表面。
[0025]口腔护理剂的“效力”在本文中包括一种或多种以下的效果:(a)达到的有效性程度,(b)达到有效性给定程度的速度,和(c)效果的持续时间(有时称为“坚固度”的特性)。效力可以绝对条件或相对条件测定,例如通过与未处理的对照或与标准处理比较。
[0026]本文中有关口腔或牙齿表面的术语“预处理”指以使该表面对随后施用的口腔护理剂更能接受和/或更易响应的这种方式,影响该表面或其接近的环境。
[0027]用织物“擦拭”表面可能,但不是必要地涉及织物对该表面的侧运动,即摩擦动作。术语“擦拭”在本文中也包括简单的拭抹,即用织物单次或重复地接触该表面,而未明显地摩擦。
[0028]“活化剂”在本文中为增强口腔护理剂效力的药剂。例如,在极端的情况下,口腔护理剂在无活化剂的存在下可能不起作用;更典型的是有活化剂比没有活化剂,口腔护理剂在体外或体内试验测定中显示出更大或更快的功效,或坚固度的改善。
[0029]活化剂的“活化有效量”为足以促进如上所定义的口腔护理剂效力的量。
[0030]“碱化剂”在本文中为提高所施用表面临近环境pH的药剂。该pH可能,但不是必要地将初始酸性pH水平提高到约7的值或更高。
[0031]“口腔可接受的”化合物、组合物或溶媒为这样的化合物、组合物或溶媒:当以本文中所公开的量滞留在口腔中,不吞咽、持续如本文中所要求的足够允许施用于口腔表面的时间,对哺乳动物无害。一般而言,该化合物、组合物或溶媒即使无意中吞咽也是无害的。
[0032]本发明的方法可认为包括至少两步,其中第一步涉及用其中已浸渍或其上涂覆口腔可接受的预处理剂例如活化剂的吸收性织物,擦拭表面来预处理口腔表面,例如牙齿表面。
[0033]织物的性质和组成不是决定性的。织物可为织造(例如密织或稀织)或非织造,并且适当地由纤维,例如衍生自任何合适植物来源例如棉花或木浆的纤维素纤维组成。这些纤维本身和纤维间的孔或空隙可提供活化剂及其他物质(如果需要)保持的部位。当用该织物擦拭表面时,在其中浸渍或其上涂覆药剂的一部分转移到所擦拭的表面。
[0034]方便地,织物可为小拭子或适用于一次性使用的样品形式。该拭子或样品基本上可为层状物品,例如纸制拭巾或更等径的物品例如棉球。一种或多种此类物品可任选安装在或多或少非吸收性结构例如棒上,例如类似于Q-tips棉签。
[0035]拭巾可任选具有可灵活或舒适操作的、或多或少非吸收性衬片,因此在该情况下,拭巾具有吸收性面和非吸收性(衬或处理)面。在该情况下,需要使拭巾的吸收性面与非吸收性面可容易地由视觉(例如颜色)和/或触觉(例如质地)区别,以使在使用中将吸收性面导向口腔或牙齿表面。
[0036]在一个实施方案中,织物以润湿拭巾或湿擦拭物的形式提供,其中将预处理剂溶解或分散于液体介质中。在另一个实施方案中,织物以基本上干燥拭巾或干燥擦拭物的形式提供,其中先前用于涂覆或浸渍该织物的大部分或所有水或其他液体介质,例如通过蒸发已经除去。根据此后一个实施方案,预处理剂从织物转移到口腔表面依靠存在于口腔中的水分。
[0037]已注意到,干燥拭巾或擦拭物的使用不仅能释放预处理剂,而且能有效地导致在施用口腔护理剂之前,将过多的唾液从口腔表面除去。
[0038]不论潮湿还是干燥,拭巾或擦拭物可以密封的多个或单独包装,例如塑料或箔包装物的形式提供,该包装在使用前除去。
[0039]在本发明方法的实施方案中,预处理步骤用擦拭工具进行,其中该擦拭工具包括以任何本文中公开的形式及其等同形式涂覆或浸渍的织物。类似地,在本发明药剂盒的实施方案中,药剂盒中涂覆或浸渍的织物组分为如上述所定义的擦拭工具。
[0040]织物可具有其中浸渍,即占据织物孔和空隙的活化剂和其他任选物质。或者或另外,在织物的一个或多个表面可存在,例如包含活化剂和其他任选物质的半固体制剂的涂层或层。本文中“含有”活化剂或其他物质的织物,例如拭巾或擦拭物的叙述将理解为包括用该药剂或物质浸渍和/或涂覆的织物。
[0041]可用本领域已知的任何合适方法提供织物上的涂层。例如涂层可如涂布涂剂一样通过喷涂、刷涂或辊涂涂覆。通常将具有预处理剂和其他任选组分的涂料组合物,以用液体溶媒,例如水、乙醇或其混合物稀释的形式,涂布于该织物的表面。然后将该织物部分或完全干燥,提供用于本发明方法的涂覆织物。
[0042]同样地,可用本领域已知的任何合适方法,用预处理剂和其他任选物质浸渍织物。例如,织物可在所需要物质的液体(例如水和/或乙醇)溶液或分散液中浸浴,或将计量体积的该溶液或分散液例如可通过喷雾或用移液管分散在该织物上。或者,该溶液或分散液可通过印迹(blotting)、海棉擦法或辊涂转移到织物上。在任何上述方法中,然后,织物可在包装前未经干燥、或部分或完全干燥后包装。
[0043]在还另一种方法中,织物可经过含有固体形式预处理剂的干浴,接着通过机械辊轧将药剂浸渍到该织物中。
[0044]在一个实施方案中,随后施用的口腔护理剂可pH依赖性活化,预处理剂或活化剂是pH调节剂。当口腔护理剂是置于碱性环境时表现最好的口腔护理剂时,例如用于使牙齿表面增白的过氧化合物,合适的活化剂为碱化剂,例如碱金属碳酸盐或碳酸氢盐例如碳酸氢钠,或碱金属或碱土金属氢氧化物例如氢氧化钠或氢氧化钙。当随后施用的口腔护理剂是置于酸性环境时表现最好的口腔护理剂时,例如用作抗龋齿治疗的氟化物盐或用于通过泡腾提供清新口感的碳酸氢盐,合适的活化剂为酸化剂,例如有机或无机酸或酸盐,如盐酸、磷酸或柠檬酸。因此在任一情况中,合适的活化剂为在口腔表面提供有利于口腔护理剂活化的pH环境的活化剂。
[0045]任选合适的缓冲剂与pH调节剂一起存在,和/或在某些情况下,该pH调节剂本身可具有缓冲活性。
[0046]作为示例,已发现用浸渍碳酸氢钠的润湿拭巾擦拭牙齿表面或模拟的牙齿表面,在提供高pH的表面环境方面意外地有效。在这点上,碱化剂浸渍拭巾的效力可通过基本上按下述进行的测试确定。
[0047]用水性溶媒配制浓度约1%至约40%重量的碱化剂溶液,提供测试溶液。该水性溶媒可主要由水组成,或可含有一种或多种另外的溶剂例如乙醇,及任选其他组分例如湿润剂。然后,向干燥的拭巾涂布不超过该拭巾吸收容量的测定体积的测试溶液。或者,该拭巾可用该测试溶液浸泡至其完全吸收的容量。任一方法,拭巾用碱化剂浸渍。
[0048]浸渍碱化剂后,拭巾可以或无需部分或完全干燥后使用。
[0049]模拟人牙齿表面合适的基体,例如合成羟磷灰石盘或牛齿,用水清洗,然后用已浸渍的拭巾擦拭。可用合适的指示剂,例如酚酞确定在所处理的表面上是否已达到pH阈值,例如在酚酞的情况下pH约为9。
[0050]本领域技术人员基于本发明公开,将容易地设计出使用适当指示剂的类似测试方案,用于评价酸化剂-浸渍的拭巾。
[0051]预处理剂或活化剂可不同于pH调节剂。例如,在一个实施方案中,当口腔护理剂为过氧化合物时,预处理剂或活化剂包括包含铁、铜或锰的化合物或络合物,例如二氯化锰、柠檬酸锰、葡萄糖酸锰、硫酸亚铁、硫酸铜、其混合物等。
[0052]在另一个实施方案中,预处理剂或活化剂为提高随后施用的口腔护理剂坚固度的聚合物。例如,当口腔护理剂为抗菌剂时,任何一种或多种存在于拭巾或其他涂覆或浸渍织物的某些聚合物,可在所治疗表面的临近环境中导致更大的抗菌活性寿命。提供抗菌活性和/或坚固度增强的聚合物在本文中称为“抗菌增强剂”(AEAs)。
[0053]用作AEAs的聚合物包括例如低聚物、均聚物、共聚物等。AEA可以是天然或合成的,可以是水不溶性或水溶性或可溶胀的。在一个实施方案中,该AEA可水化或在唾液中形成水凝胶。通常AEA的重均分子量为约100至约1,000,000,例如约1,000至约1,000,000,或约2,000至约500,000,或约2,500至约250,000。
[0054]AEAs具有含至少一个促进释放的基团,及至少一个促进保持的有机基团的化学结构。“促进释放的基团”为使AEA与口腔(例如牙齿)表面粘附或基本上、粘合、粘结或结合的基团。“促进保持的有机基团”,通常为疏水性的,使随后施用的抗菌剂与AEA粘附或结合,因此提高了该抗菌剂在口腔表面的滞留。
[0055]举例来讲,AEA为阴离子聚合物,例如包含含有重复单元的链或主链的聚羧酸酯,该重复单元各自具有至少一个碳原子,以及与链或主链中的原子偕位、连位或结合的至少一个直接或间接促进释放的单价侧基和至少一个直接或间接促进保持的单价侧基。此类聚羧酸酯可以游离酸形式或作为部分或完全中和的碱金属(例如钾、钠)盐或铵盐采用。此外的实例为马来酸酐或马来酸与另一种可聚合烯属不饱和单体例如甲基乙烯基醚的1∶4-4∶1共聚物,该共聚物的分子量为约30,000至约1,000,000,例如约30,000至约500,000。聚乙烯基甲基醚/马来酸酐(PVME/MA)共聚物可从例如ISP,Wayne,NJ以GantrezTM商标例如GantrezTMS-97获得。
[0056]用于本发明方法第一步的拭巾、拭子或其他织物除预处理剂之外,可具有在其上涂覆或在其中浸渍的另外组分。例如,潮湿的拭巾可含有湿润剂例如甘油或山梨醇以及预处理剂,以帮助该拭巾保持潮湿。
[0057]用于本发明方法的织物,例如潮湿或干燥的拭巾,可任选在其中或在其上含有至少一种香料。可使用任何口腔可接受的天然或合成香料,例如油、醛、酯、醇等及混合物,包括其多组分混合物。香料包括但不限于:香草醛、洋苏草、墨角兰、欧芹油、留兰香油、肉桂油、冬绿油(水杨酸甲酯)、薄荷油、丁香油、玉桂油、茴香油、桉树油、柑橘油,包括那些衍生自柠檬、柑橘、酸橙、葡萄柚、杏、香蕉、葡萄、苹果、草莓、樱桃、菠萝等的水果油和香精,豆和坚果例如咖啡、可可、可乐果、花生、杏仁等来源的调味剂,被吸收和封囊化的香料等。本文中的香料也包括在口中提供芳香和/或其他感觉效果,包括冷或暖效果的组分。示例性的此类组分包括薄荷醇、3-萜醇乙酸酯、乳酸薄荷醇酯、樟脑、桉树油、桉油醇、茴香脑、丁香酚、肉桂、烷酮(oxanone)、α-紫罗兰酮(irisone)、propenyl guaiethol、百里酚、芫荽醇、苯甲醛、肉桂醛、N-乙基-对-薄荷烷-3-甲酰胺、3-1-薄荷氧基丙-1,2-二醇、N,2,3-三甲基-2-异丙基-丁酰胺、肉桂醛甘油缩醛(CGA)、薄荷酮甘油缩醛(MGA)、辣椒、烟酸苄酯等。
[0058]在拭巾或其他织物中加入合适的香料可能非常有益。某些使用者有可能发现用含有碳酸氢盐或其他活化剂的潮湿或干燥拭巾擦拭口腔表面,例如擦拭牙齿的动作不舒服或不令人愉快。香料在拭巾中的存在可大大改善此类使用者对擦拭步骤感觉上的接受性,因此改善了使用者的依从性。
[0059]在提供口腔表面有效预处理的擦拭期间,擦拭的持续时间和侧运动(摩擦)(如果有)的强度,可由本领域技术人员不用做不适当的试验就可确定。可以预期,润湿拭巾将比干燥拭巾需要更短的与表面接触的持续时间,但是在任一情况下,擦拭约3至约300秒,例如约5至约120秒,或约10至约60秒通常足够。
[0060]在再一个实施方案中,提供了用于对增白处理的牙齿表面预处理的物品。该物品包含润湿拭巾,该拭巾载有有效量的口腔可接受碱化剂例如碳酸氢钠的水溶液,当用该拭巾擦拭表面时,该有效量在牙齿表面提供至少约7的pH。该拭巾足够湿润,以维持碱化剂处于基本上溶解形式的程度,因此施用于牙齿表面时基本上无磨蚀作用。
[0061]该实施方案中的拭巾通常用基本上水不渗透性包装物,例如塑料或箔制小袋一次使用性包装。如上所述,其他组分可与碱化剂一起存在,包括例如一种或多种湿润剂和香料。
[0062]本发明方法的第二步涉及在如上所述预处理后,将包含口腔护理剂,例如过氧化合物、氟离子源或碳酸氢盐的组合物施用于口腔表面。
[0063]该组合物可为,例如漱口剂或清洗剂、口腔喷雾剂、洁齿剂、口腔带、液体增白剂或口香糖。清洗剂包括适用于通过装置例如高压水喷嘴冲洗的液体。洁齿剂包括但不限于牙膏、凝胶和散剂。本文中“液体增白剂”包括半液体组合物例如凝胶以及可流动液体,只要该组合物能够通过用牙刷或其他合适的装置涂抹,施用于牙齿表面。“涂抹”在本发明上下文中指将组合物的薄层施用于牙齿表面,例如,如Colgate-Palmolive Co.,New York,NY销售的ColgateSimplyWhiteNight清洁增白凝胶的包装上指明的那样。
[0064]本文中活性组分或载体组分的分类清晰且方便,且不应得出特定的组分必须在该组合物中按照其在本文中的分类起作用的推论。此外,特定组分可起多种作用,因此本文中组分作为例证一种功能类别的公开,不排除它也可以例证另一种功能类别的可能。
[0065]在有效的口腔护理活性剂中,非限定性地有那些针对牙齿的外观和结构变化,牙菌斑、结石、龋牙、空洞、脓肿、炎性和/或出血性龈、龈炎、大多数口腔感染和/或炎性病症、牙齿敏感性、口臭等的治疗和预防的活性剂。因此,用于本发明方法和药剂盒的组合物可含有一种或多种活性剂例如增白剂、磨擦剂、防结石(抑制牙结石)剂、氟离子源、亚锡离子源、锌离子源、抗微生物剂、抗氧化剂、催涎剂、口腔清净剂、防牙菌斑剂、抗炎剂、脱敏剂、牙周病药剂、止痛剂和营养素。
[0066]本文中有效的活性剂通常以经选择是安全和有效的量存在于组合物中。在本发明上下文中“安全和有效的”量为当组合物按本文所描述的重复使用时,足以提供所期望的益处,例如治疗、预防或美容作用,而无不适当的副作用例如毒性、刺激性或变应性反应,并与合理的益处/风险比率相称的量。该安全和有效的量通常,但不是必须,应在由适当的管理机构批准的范围内。在具体的情况下,安全和有效的量取决于许多因素,包括所期望的特定益处或正治疗或需要预防的病症、使用或被给予的特定患者、组合物、使用的频率和持续时间等。
[0067]在有效的载体中,有稀释剂、碳酸氢盐、pH调节剂、表面活性剂、泡沫调节剂、特定口腔护理活性剂的稳定剂包括过氧化物稳定剂、增稠剂、粘性调节剂、口感调节剂、湿润剂、甜味剂、香料和着色剂。可任选存在一种载体物质或多于一种相同或不同类别的载体物质。
[0068]在一个实施方案中,组合物包括至少一种过氧化合物作为增白剂,以及任选一种或多种另外的增白剂例如二氧化氯、亚氯酸盐和次氯酸盐(例如,碱金属和碱土金属例如锂、钾、钠、镁、钙和钡的亚氯酸盐和次氯酸盐)。合适的过氧化合物包括过氧化氢、碱金属和碱土金属的过氧化物、有机过氧化合物和过氧酸及其盐。任何释放过羟基(OOH-)离子的口腔可接受的化合物是有效的。过氧化合物可任选以聚合物-过氧化物复合物,例如聚乙烯吡咯烷酮-过氧化氢复合物的形式存在。
[0069]碱金属和碱土金属的过氧化物包括过氧化锂、过氧化钾、过氧化钠、过氧化镁、过氧化钙和过氧化钡。
[0070]有机过氧化合物包括,例如过氧化碳酰氨(也称为过氧化氢脲)、甘油基过氧化氢、烷基过氧化氢、二烷基过氧化物、烷基过氧酸、过氧酯、二酰基过氧化物、过氧化苯甲酰、单过氧邻苯二甲酸酯(盐)等。
[0071]过氧酸及其盐包括有机过氧酸例如烷基过氧酸和单过氧邻苯二甲酸盐,以及无机过氧酸盐包括碱金属和碱土金属例如锂、钾、钠、镁、钙和钡的过硫酸盐、二过硫酸盐、过碳酸盐、过磷酸盐、过硼酸盐和过硅酸盐。另一种有效的过氧化合物是过一水焦磷酸钠。
[0072]增白剂以当按照本文中所公开的内容施用时,有效导致牙齿表面增白的总量存在于本发明实施方案的组合物中。以组合物重量计,过氧化合物可示例性地以相当于约0.1%至约10%,例如约1%至约5%的过氧化氢总量存在。
[0073]如上所指出,当存在于组合物中的口腔护理剂为过氧化合物时,用于预处理口腔表面的织物可含有过氧化合物的活化剂,例如碱化剂,或铁、铜或锰化合物或络合物。
[0074]在再一个实施方案中,组合物包含氟离子源,例如氟化物、单氟磷酸盐或氟硅酸盐。可使用口腔可接受的任何这种盐,包括但不限于碱金属(例如钾、钠)、铵、亚锡和铟盐等。通常使用释放氟离子的水溶性盐。一种或多种释放氟离子的盐以提供共约100至约20,000ppm,约200至约5,000ppm,或约500至约2,500ppm氟离子的量存在于该实施方案的组合物中。当氟化钠为唯一存在的释放氟离子的盐时,例如约0.01%至约5%,约0.05%至约1%或约0.1%至约0.5%重量的氟化钠可存在于组合物中。
[0075]如上所指出,当存在于组合物中的口腔护理剂为氟离子源时,用于预处理口腔表面的织物可含有氟化物源的活化剂,例如酸化剂。
[0076]在再一个实施方案中,组合物包含至少一种碳酸氢盐,用于例如由于泡腾和二氧化碳的释放赋予牙齿和牙龈“清洁感觉”。可使用任何口腔可接受的碳酸氢盐,包括但不限于碱金属碳酸氢盐例如碳酸氢钠和碳酸氢钾、碳酸氢铵等。以组合物重量计,一种或多种碳酸氢盐任选存在的总量为0.1%至约50%,例如约1%至约20%。
[0077]如上所指出,当存在于组合物中的口腔护理剂为碳酸氢盐时,用于预处理口腔表面的织物可含有过氧化合物的活化剂,例如酸化剂以促进泡腾。
[0078]组合物可任选包含至少一种用作例如清洁剂和/或抛光剂的磨擦剂。可使用任何口腔可接受的磨擦剂,但是应选择类型、细度(粒度)和磨擦剂的量,以使牙釉质在组合物的正常使用中不被过度地磨损。合适的磨擦剂包括但不限于例如硅胶、水合二氧化硅、热解二氧化硅或沉淀二氧化硅形式的二氧化硅;例如水合氧化铝或煅烧氧化铝形式的氧化铝;硅酸铝;膨润土;不溶性磷酸盐;碳酸钙;树脂型磨擦剂,例如脲-醛缩合产物等。在用作磨擦剂的不溶性磷酸盐中,有正磷酸盐、聚偏磷酸盐和焦磷酸盐。示例性实例有正磷酸二钙二水合物、焦磷酸钙、β-焦磷酸钙、磷酸三钙、聚偏磷酸钙和不溶性聚偏磷酸钠。一种或多种磨擦剂任选以磨擦有效总量,通常约5%至约70%,例如约10%至约50%或约15%至约30%重量存在于组合物中。磨擦剂(如果存在)的平均粒度通常为约0.1至约30μm,例如约1至约20μm或约5至约15μm。
[0079]在上述磨擦剂中,包括二氧化硅、水合二氧化硅、热解二氧化硅、硅胶及沉淀二氧化硅、氧化铝、水合氧化铝、煅烧氧化铝、硅酸铝和膨润土的含硅和/或含铝磨擦剂,当以磨擦有效量使用时,通常与过氧化合物不相容,大部分是因为例如这些的矿物质产品中可能存在的过渡金属杂质。因此当组合物中包括过氧化合物时,应避免此类不相容的磨擦剂。如果需要,在含有过氧化合物的组合物中可包括与过氧化合物不相容的磨擦剂,例如不溶性磷酸盐。
[0080]在特定的实施方案中,以组合物重量计,一种或多种含硅和/或含铝磨擦剂,例如水合二氧化硅存在的总量为约15%至约30%。
[0081]组合物可任选包括主要因其高清洁功效而选择的第一种磨擦剂,和主要因其抛光功效和/或增强口感而选择的第二种磨擦剂。此类第一种和第二种磨擦剂在本文中分别称为“高度清洁”和“prophy”磨擦剂。例如,以组合物重量计,可包括高度清洁二氧化硅和prophy二氧化硅各自示例性的总量为约5%至约15%。
[0082]组合物可任选包含至少一种抗微生物(例如抗菌)剂。可使用任何口腔可接受的抗微生物剂,包括但不限于:三氯生(5-氯-2-(2,4-二氯苯氧基)苯酚);2,2′-二羟基-5,5′-二溴二苯基醚;8-羟基喹啉及其盐;铜(II)化合物例如氯化铜(II)、氟化铜(II)、硫酸铜(II)和氢氧化铜(II);锌离子源例如柠檬酸锌、硫酸锌、甘氨酸锌和柠檬酸锌钠;邻苯二甲酸及其盐,例如邻苯二甲酸镁一钾;海克替啶;奥替尼啶;血根碱;氯化苯甲烃铵;水杨酰苯胺;度米芬;氯化烷基吡啶,例如氯化鲸蜡基吡啶(CPC)(包括CPC与锌和/或酶的组合)、氯化十四烷基吡啶及氯化N-十四烷基-4-乙基吡啶;奥替尼啶;碘;磺胺类;二双胍类例如阿来西定、氯己定及二葡萄糖酸氯己定;苯酚类;哌啶子基衍生物,例如地莫匹醇和辛哌醇;木兰提取物;葡萄籽提取物;苯酚;百里酚;丁香酚;薄荷醇;香茅醇;香芹酚;柠檬醛;桉油醇;儿茶酚;4-烯丙基儿茶酚;己基间苯二酚;卤化双酚类,例如2,2′-亚甲基双(4-氯-6-溴苯酚);水杨酸甲酯;抗生素,例如奥格门汀、阿莫西林、四环素、多西环素、米诺环素、甲硝唑、新霉素、卡那霉素及克林霉素等。Gaffar等的美国专利No.5,776,435中提供了有效抗菌剂的再一个示例性列表,该专利通过引用结合到本文中。一种或多种抗微生物剂任选以抗微生物有效总量存在,以组合物重量计通常为约0.05%至约3%,例如约0.1%至约1%。
[0083]在抗微生物剂中,非离子剂例如卤化二苯醚(例如三氯生和2,2′-二羟基-5,5′-二溴二苯基醚)和苯酚化合物通常与过氧化合物不相容,因此当组合物中包括过氧化合物时应避免此类化合物。
[0084]如上所指出,当存在于组合物中的口腔护理剂为非阳离子抗菌剂时,用于预处理口腔表面的织物可含有AEA,例如PVME/MA共聚物,以提高抗菌剂的坚固度。
[0085]组合物可任选包含至少一种防结石剂。可使用任何口腔可接受的防结石剂,包括但不限于磷酸酯(盐)和聚磷酸酯(盐)(例如焦磷酸酯(盐))、聚氨基丙磺酸(AMPS)、柠檬酸锌三水合物、多肽例如聚天门冬氨酸和聚谷氨酸、聚烯属磺酸酯、聚烯属磷酸酯,二膦酸酯(盐)例如氮杂环烷烃-2,2-二膦酸酯(盐)(例如氮杂环庚烷-2,2-二膦酸)、N-甲基氮杂环戊烷-2,3-二膦酸、乙烷-1-羟基-1,1-二膦酸(EHDP)及乙烷-1-氨基-1,1-二膦酸酯(盐)、膦酰基烷烃羧酸及任何这些防结石剂的盐,例如其碱金属盐和铵盐。有效的示例性无机磷酸盐和聚磷酸盐包括一碱价、二碱价和三碱价磷酸钠、三聚磷酸钠、四聚磷酸钠、焦磷酸一-、二-、三-和四钠、焦磷酸二氢二钠、三偏磷酸钠、六偏磷酸钠等,其中钠可任选被钾或铵代替。其他有效的防结石剂包括PVME/MA共聚物,例如可从ISP,Wayne,NJ,以GantrezTM商标获得的那些共聚物。一种或多种防结石剂任选以防结石有效总量存在于组合物中,通常为约0.01%至约50%,例如约0.05%至约25%,或约0.1%至约15%重量。
[0086]在特定的实施方案中,任选与总量约1%至约15%重量的一种或多种聚磷酸盐,例如焦磷酸四钠、焦磷酸四钾、三聚磷酸钠和/或三聚磷酸钾一起,一种或多种PVME/MA共聚物以组合物重量计为约0.3%至约3%的总量存在。
[0087]组合物可任选包含至少一种亚锡离子源,用于例如帮助减少龈炎、牙菌斑、结石、龋齿或敏感性。可使用任何口腔可接受的亚锡离子源,包括但不限于氟化亚锡、其他卤化亚锡例如氯化亚锡二水合物、焦磷酸亚锡、有机亚锡羧酸盐例如甲酸亚锡、乙酸亚锡、葡萄糖酸亚锡、乳酸亚锡、酒石酸亚锡、草酸亚锡、丙二酸亚锡和柠檬酸亚锡、stannous ethylene glyoxide等。以组合物重量计,一种或多种亚锡离子源任选并示例性以约0.01%至约10%,例如约0.1%至约7%,或约1%至约5%的总量存在。
[0088]组合物可任选包含至少一种锌离子源,用作例如抗微生物剂、防结石剂或口腔清净剂。可使用任何口腔可接受的锌离子源,包括但不限于柠檬酸锌、硫酸锌、甘氨酸锌、柠檬酸锌钠等。以组合物重量计,一种或多种锌离子源任选并示例性以约0.05%至约3%,例如约0.1%至约1%的总量存在。
[0089]组合物可任选包含至少一种抗氧化剂。可使用任何口腔可接受的抗氧化剂,包括但不限于丁基化羟基茴香醚(BHA)、丁基化羟基甲苯(BHT)、维生素A、胡萝卜素类、维生素E、黄酮类、多酚类、抗坏血酸、草药抗氧化剂、叶绿素、褪黑激素等。一种或多种抗氧化剂任选以抗氧化有效总量存在。在特定的实施方案中,BHA和BHT中至少一种以约0.01%至约0.1%重量的总量存在于组合物中。
[0090]组合物可任选包含用于例如改善口腔干燥的催涎剂(唾液刺激剂)。可使用任何口腔可接受的催涎剂,包括但不限于食用酸例如柠檬酸、乳酸、苹果酸、琥珀酸、抗坏血酸、己二酸、富马酸和酒石酸。一种或多种催涎剂任选以唾液刺激有效总量存在于组合物中。
[0091]组合物可任选包含口腔清净剂。可使用任何口腔可接受的口腔清净剂,包括但不限于锌盐例如葡萄糖酸锌、柠檬酸锌和亚氯酸锌、α-紫罗兰酮等。一种或多种口腔清净剂任选以口腔清净有效总量存在于组合物中。
[0092]组合物可任选包含防牙菌斑剂,包括牙菌斑破坏剂。可使用任何口腔可接受的防牙菌斑剂,包括但不限于:亚锡、铜、镁和锶盐、二甲聚硅氧烷共聚醇(copolyol)例如鲸蜡基二甲聚硅氧烷共聚醇、番木瓜酶、葡糖淀粉酶、葡萄糖氧化酶、尿素、乳酸钙、甘油磷酸钙、聚丙烯酸锶及螯合剂例如柠檬酸和酒石酸及其碱金属盐。一种或多种防牙菌斑剂任选以防牙菌斑有效总量存在于组合物中。
[0093]组合物可任选包含至少一种抗炎剂。可使用任何口腔可接受的抗炎剂,包括但不限于:甾体抗炎剂例如氟轻松(flucinolone)和氢化可的松;及非甾体抗炎剂(NSAIDs),例如酮咯酸、氟比洛芬、布洛芬、萘普生、消炎痛、双氯芬酸、依托度酸、消炎痛、舒林酸、托美丁、酮洛芬、非诺洛芬、吡罗昔康、萘丁美酮、阿司匹林、二氟尼柳、甲氯芬那酸盐、甲芬那酸、羟基保泰松和苯基丁氮酮。一种或多种抗炎剂任选以抗炎有效量存在于组合物中。
[0094]组合物可任选包含至少一种脱敏剂。在这方面可使用示例性钾盐例如柠檬酸钾、酒石酸钾、氯化钾、硫酸钾和硝酸钾,同样可使用硝酸钠。或者或另外可使用局部或全身止痛剂例如阿司匹林、可待因、扑热息痛、水杨酸钠或水杨酸三乙醇胺。一种或多种脱敏剂和/或止痛剂任选以脱敏和/或止痛有效量存在于组合物中。
[0095]组合物可任选包含至少一种营养素。合适的营养素包括维生素、矿物质和氨基酸。
[0096]组合物可任选包含至少一种增稠剂,用于例如赋予组合物所需要的一致性和/或口感。增稠剂包括有机、粘土-基和胶体二氧化硅增稠剂。可使用任何口腔可接受的有机增稠剂,包括但不限于:卡波姆,也称为羧基乙烯基聚合物,例如以CarbopolTM商标销售的那些卡波姆包括Carbopols 934、956、974和980;聚乙烯吡咯烷酮;角叉菜胶,也称为爱尔兰苔藓,更特别是ι-角叉菜胶(ι-角叉菜胶);纤维素类聚合物,例如羟乙基纤维素、羟丙基甲基纤维素、羧甲基纤维素(CMC)及羧甲基-羟乙基纤维素及其盐,例如CMC钠;淀粉及天然树胶例如梧桐胶、黄原胶、***胶和黄芪胶。可使用任何口腔可接受的粘土-基增稠剂,包括包含天然、改性和/或合成粘土类的此类增稠剂。示例性的包含至少一种绿土类粘土的增稠剂,包括贝得石(beidellite)、膨润土、水辉石、蒙脱石、滑石粉和镁滑润石(stevensite),并且可使用合成相应物例如胶体硅酸镁铝和LaponiteTM。也可使用疏水性改性的粘土,例如疏水性改性的膨润土。以组合物重量计,一种或多种增稠剂任选以约0.01%至约15%,例如约0.1%至约10%,或约0.2%至约5%的总量存在。
[0097]组合物可任选包含至少一种粘性调节剂,用于例如抑制组分的沉淀或分离,或用于提高液体组合物搅拌时的再分散。可使用任何口腔可接受的粘性调节剂,包括但不限于矿物油、凡士林、粘土及有机改性的粘土、二氧化硅等。以组合物重量计,一种或多种粘性调节剂任选以约0.01%至约10%,例如约0.1%至约5%的总量存在。
[0098]组合物可任选包含至少一种pH调节剂。此类pH调节剂包括降低pH的酸化剂、升高pH的碱化剂和将pH控制在所需要范围内的缓冲剂。可使用任何口腔可接受的pH调节剂,包括但不限于羧酸、磷酸和磺酸、酸盐(例如柠檬酸一钠、柠檬酸二钠、苹果酸一钠等)、碱金属氢氧化物例如氢氧化钠、碳酸盐例如碳酸钠、碳酸氢盐、倍半碳酸盐、硼酸盐、硅酸盐、磷酸盐(例如磷酸二氢钠、磷酸三钠、焦磷酸盐等)、咪唑等。一种或多种pH调节剂任选以将组合物有效维持在所需要pH范围内的总量存在。
[0099]组合物可任选包含至少一种表面活性剂,用于例如使其他组分增溶,并因此提供提高的稳定性,用于帮助通过去垢清洁牙齿表面,及用于搅动时提供泡沫,例如在刷牙期间。可使用任何口腔可接受的表面活性剂,包括阳离子、阴离子、非离子和两性类型的表面活性剂。
[0100]合适的阳离子表面活性剂包括但不限于具有C8-20脂族链的季铵化合物,例如氯化月桂基三甲基铵、氯化鲸蜡基吡啶、氟化鲸蜡基吡啶、溴化鲸蜡基三甲基铵、氯化二异丁基苯氧基乙基-二甲基苄基铵、亚硝酸可可烷基三甲基铵等。可污染牙齿的阳离子化合物,例如氯己定可考虑在本文中使用,不过要留意该缺点。
[0101]合适的阴离子表面活性剂包括但不限于C8-20烷基硫酸、C8-20脂肪酸的磺化甘油单酯、肌氨酸、牛磺酸等的水溶性盐。这些和其他种类的阴离子表面活性剂的示例性实例包括月桂基硫酸钠、椰子油磺酸甘油单酯钠、月桂基肌氨酸钠、月桂基异乙二磺酸钠、月桂基磺基乙酸钠、月桂基醚羧酸钠、十二烷基苯磺酸钠,以及月桂酰基肌氨酸、肉豆蔻酰基肌氨酸、棕榈酰基肌氨酸、硬脂酰基肌氨酸和油酰基肌氨酸的钠和钾盐。
[0102]合适的非离子表面活性剂包括但不限于泊咯沙姆、聚氧化乙烯脱水山梨醇酯、乙氧基化脂肪醇、乙氧基化烷基酚、叔胺氧化物、叔膦氧化物、二烷基亚砜等。
[0103]合适的两性表面活性剂包括但不限于具有阴离子基团例如羧酸酯、硫酸酯、磺酸酯、磷酸酯或膦酸酯的C8-20脂族仲胺和叔胺衍生物。实例包括可可酰氨基丙基甜菜碱和月桂酰氨基丙基甜菜碱。
[0104]以组合物重量计,一种或多种表面活性剂任选以约0.01%至约10%,例如约0.05%至约5%或约0.1%至约2%的总量存在。
[0105]组合物可任选包含至少一种泡沫调节剂,用于例如增加由搅动,例如刷组合物产生泡沫的量、稠度或稳定性。可使用任何口腔可接受的泡沫调节剂,包括但不限于聚乙二醇类(PEGs),也称为聚氧化乙烯。高分子量的PEGs是合适的,包括那些平均分子量为约200,000至约7,000,000,例如约500,000至约5,000,000或约1,000,000至约2,500,000的PEG。以组合物重量计,一种或多种PEG任选以约0.1%至约10%,例如约0.2%至约5%或约0.25%至约2%的总量存在。
[0106]组合物可任选包含至少一种湿润剂,用于例如防止组合物由于暴露于空气中而硬化,和/或用于改善口感。可使用任何口腔可接受的湿润剂,包括但不限于多元醇例如丙二醇、丁二醇、丙三醇、山梨糖醇、木糖醇或低分子量PEGs。大部分湿润剂也起甜味剂的作用。以组合物重量计,一种或多种湿润剂任选以约1%至约80%,例如约5%至约65%或约10%至约50%的总量存在。
[0107]在特定的实施方案中,组合物为凝胶剂,该凝胶剂包含占组合物重量约10%至约60%重量的甘油,任选还有量为约2%至约20%重量的低分子量PEG例如PEG 600。
[0108]在另一个特定的实施方案中,组合物为糊剂,该糊剂包含占组合物重量约10%至约50%的山梨醇,任选还有量为约5%至约25%的甘油。
[0109]组合物可任选包含至少一种甜味剂,用于例如增加组合物的味道。可使用任何口腔可接受的天然或人造、有营养或无营养的甜味剂,包括但不限于葡萄糖、聚葡萄糖、蔗糖、麦芽糖、糊精、干转化糖、乳糖、甘露糖、木糖、核糖、果糖、半乳糖、玉米糖浆(包括高果糖玉米糖浆和玉米糖浆固体)、部分水解淀粉、氢化淀粉水解产物、山梨醇、甘露醇、木糖醇、麦芽糖醇、异麦芽酮糖醇(isomalt)、三氯蔗糖(sucralose)、阿斯巴甜、乙酰舒泛、纽甜(neotame)、D-色氨酸、糖精及其盐(例如糖精钠)、祝马丁、二氢查耳酮、二肽-基强甜味剂、环磺酸盐(例如环磺酸钠)等。一种或多种甜味剂任选以强烈取决于所选择特定甜味剂的总量存在,但以组合物重量计,通常约0.005%至约5%。
[0110]在特定的实施方案中,组合物包含占约0.1%至约1%重量的糖精钠。
[0111]组合物可任选包含至少一种香料,用于例如增加组合物的味道。可使用任何口腔可接受的天然或合成香料,包括但不限于上述作为涂覆或浸渍织物的任选组分所列举的那些香料。以组合物重量计,一种或多种香料任选以约0.01%至约5%,例如约0.1%至约2.5%的总量存在。
[0112]组合物可任选包含至少一种着色剂。本文中的着色剂包括颜料、染料、色淀和赋予特定光彩或反射性的试剂例如珠光剂。着色剂可起许多作用,包括例如在牙齿表面提供白色或浅色涂层,在已与组合物有效接触的牙齿表面位置起指示剂作用,和/或改变组合物的外观,特别是颜色和/或浑浊,以提高对消费者的吸引力。可使用任何口腔可接受的着色剂,包括但不限于滑石、云母、碳酸镁、碳酸钙、硅酸镁、硅酸镁铝、二氧化硅、二氧化钛、氧化锌;红、黄、棕和黑色氧化铁;亚铁氰化铁铵、锰紫罗兰、群青、二氧化钛化的云母、氯氧化铋等。以组合物重量计,一种或多种着色剂任选以约0.001%至约20%,例如约0.01%至约10%或约0.1%至约5%的总量存在。
[0113]在特定的实施方案中,组合物可包含两种或多种具有对比色的组分,当从管或其他分配器中挤出时提供有斑纹的效果。例如,组合物可包含含有兰色着色剂的凝胶组分,和含有显白色二氧化钛的糊剂组分。
[0114]凝胶组合物可通过将组分在任何合适的混合装置中混合制备。糊剂组合物可通过以下通用方法制备。将水和增稠剂,通常与湿润剂和甜味剂一起,在合适的混合装置中混合,直到获得均匀的凝胶相。可向凝胶相中加入其他组分,例如颜料和氟离子源,进一步混合直到均匀。其后,加入磨擦剂和/或其他所需要的组分例如防结石剂、抗菌剂、香料和表面活性剂,并将所得混合物任选在约20至约100mmHg的真空下高速混合,提供均匀的可挤出糊剂。
[0115]由本发明方法处理的口腔表面可为人或非人受试者,例如非人哺乳动物受试者如伴侣动物,例如狗或猫的口腔表面。在一个实施方案中,口腔表面为一个或多个自然牙齿表面,但是该方法也适用于人造牙齿表面,例如牙冠、牙髓盖、填料、牙桥、托牙或牙齿植入物。
[0116]方法的实施可由本文中所描述的单一两步施用组成,或可包括重复此类施用。在一个实施方案中,本发明方法以固定的间隔重复实施,例如在家和/或在专业或临床场所,按每天两次或一次、每周两次或一次、每月两次或一次的计划或方案实施。
[0117]牙齿表面白度的增加可由视觉观察,例如借助于比色图表、比色计(gauges)或色标,例如,如Browning(2003),Journal of EstheticRestorative Dentistry 15 Supp.1,S13-S20所描述,该文献通过引用结合到本文中。
[0118]或者,白度的增加可通过比色法,用任何合适的仪器例如Minolta色度计,例如CR-321型(Minolta Corp.,Ramsey,NJ)测定。仪器可编程控制,例如,根据国际照明委员会(CIE)建立的标准测定HunterLab值或L*a*b*值。L*a*b****提供三维颜色空间的数字表示,其中L*代表亮度轴,a*代表红-绿轴及b*代表黄-蓝轴。L*和b*轴通常为牙齿白度测定的最大适用性。白度的增加可根据处理前、后L*、a*和b*值的差值计算,或根据未处理和处理表面之间的差值计算。有用的参数为ΔE*,用以下公式,按L*、a*和b*值的差值平方和的平方根计算:
ΔE*=[(ΔL*)2+(Δa*)2+(Δb*)2]1/2
ΔE*值越高,表明白度增加越大。在各个实施方案中,本发明方法可影响ΔE*值至少约1,或至少约3,或至少约5。
[0119]可评价本发明增白治疗的效力,例如,在临床研究中使用人志愿者,或在动物体内根据适当的方案进行。
[0120]用于增白治疗评价的合适体外方案也可获得,包括本文实施例中及发表的文献中所描述的那些。见例如Stookey等(1982),Journalof Dental Research 61(11),1236-1239,和Rice等(2001),Journal ofClinical Dentistry 12(2),34-37,两者均通过引用结合到本文中。
[0121]本发明的药剂盒包括包含口腔护理剂的组合物,例如包含口腔可接受的过氧化合物的增白组合物。该组合物,如上所描述,可示例性为漱口液或清洗液、口腔喷雾剂、凝胶或糊剂洁齿剂、口腔带、液体增白剂或口香糖。组合物通常以合适的包装提供,例如分配容器,如当组合物为洁齿剂时为管或泵。
[0122]药剂盒还包含吸收性织物,例如湿润或干燥拭巾形式的织物,其中已浸渍或其上涂覆口腔可接受的预处理剂。预处理剂可为口腔护理剂的活化剂,例如碱化剂例如碱金属碳酸盐或碳酸氢盐,例如碳酸氢钠,其中该口腔护理剂为过氧化合物。
[0123]药剂盒的织物和口腔护理剂组合物组分可分别包装或一起包装,并可分别销售或作为一个产品销售。一般提供根据本发明方法使用药剂盒的说明书。
[0124]对于在专业场所(例如牙医或牙科卫生学者办公室或诊所)或使用者在家或旅行时实施本发明,药剂盒是有用的。虽然特别适用于人使用,但药剂盒也可用于非人动物,例如家庭宠物如狗的口腔护理给予。
[0125]通过参考以下非限定性实施例,可进一步理解本发明。
实施例
实施例1
[0126]制备具有表1所示组合物的溶液A-I。这些溶液的每一种均能均匀地分散在拭巾上。
表1:溶液A-I的组合物
组分 | 重量% | ||||||||
A | B | C | D | E | F | G | H | I | |
乙醇 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
甘油 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 |
碳酸钠 | 5 | ||||||||
碳酸氢钠 | 5 | 10 | |||||||
氢氧化钠 | 5 | ||||||||
氢氧化钙 | 5 | ||||||||
磷酸 | 5 | ||||||||
盐酸 | 5 | ||||||||
柠檬酸 | 5 | ||||||||
Gantrez | 5 | ||||||||
调味剂 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
水 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 | 适量 |
[0127]测试了用溶液A润湿的拭巾对合成羟磷灰石(SHAP)盘表面pH的影响。最初,SHAP盘用水洗涤以除去任何细颗粒和灰尘。然后该盘表面用含有溶液A的润湿拭巾擦拭。然后用酚酞指示剂测试该表面的pH。酚酞变成粉红色,表明pH>9。
[0128]用牛齿作为基体进行类似的测试。再用含有溶液A的润湿拭巾擦拭,按酚酞指示,得到的表面pH>9。
[0129]用溶液B、C和D润湿的拭巾获得类似的结果。
实施例2
[0130]用含有实施例1中溶液B的润湿拭巾擦拭进行或未进行表面预处理,比较ColgateSimply White液体增白剂使模拟牙齿表面(咖啡染色的蛋壳或茶染色的Formica层压材料)增白的效力。
[0131]蛋最初在沸水中煮20分钟。冷却后,将蛋室温浸泡在咖啡中30分钟,然后用水洗涤。选择咖啡染色均匀的蛋进行测试,每次处理两个蛋。将每个蛋划分成三个区域。第一个区域用浸泡在实施例1中溶液B的拭巾擦拭。第二个区域用水浸泡的拭巾(作为对照擦拭。第三个区域未处理。其后立即,将液体增白剂施用到第一和第二个区域,并放置2.5分钟,接着用流动的自来水洗涤该蛋。
[0132]通过与第三个区域的五个部位比较,测定了第一个和第二个区域中各自五个部位增白的程度。使用Minolta CR-321型色度计,用如上所描述的L*a*b****测定颜色变化,其中ΔE*值越高,表明白度增加越大。结果如表2所示。
表2:蛋壳白度的增加
处理 | 平均ΔE* |
用水擦拭,然后施用液体增白剂 | 8.08 |
用溶液B擦拭,然后施用液体增白剂 | 19.20 |
[0133]在茶染色的层压材料上重复该测试。液体增白剂施用了三次,每次持续时间2分钟,各自预先用含有水或溶液B的拭巾擦拭。色度计结果如表3所示。
表3:层压材料白度的增加
处理 | 平均ΔE* |
用水擦拭,然后施用液体增白剂 | 6.60 |
用溶液B擦拭,然后施用液体增白剂 | 13.28 |
[0134]当表面按照本发明用含有溶液B的拭巾擦拭预处理时,在两表面上可见增白显著改善。增白的改善也可用含有其他碱化剂(溶液A、C和D)的拭巾获得。在这些研究中,碱化剂的效力顺序如下:碳酸氢钠(B)>碳酸钠(A)>氢氧化钠(C)>氢氧化钙(D)。
Claims (34)
1.一种提高口腔护理剂效力的方法,所述方法包括通过用吸收性织物擦拭表面来预处理口腔表面,该吸收性织物中已浸渍或其上涂覆口腔可接受的预处理剂,其中所述擦拭将有效量的预处理剂从所述织物转移至所述口腔表面,其后将包含所述口腔护理剂的组合物施用于所述口腔表面。
2.权利要求1的方法,其中所述预处理剂为所述口腔护理剂的活化剂,且其中所述擦拭将活化有效量的所述活化剂从所述织物转移至所述口腔表面。
3.权利要求1的方法,其中所述口腔表面为牙齿表面。
4.权利要求1的方法,其中所述吸收性织物为拭巾形式。
5.权利要求1的方法,其中所述吸收性织物还含有香料。
6.权利要求1的方法,其中所述口腔护理剂可pH依赖性活化,且其中所述预处理剂为pH调节剂,该pH调节剂在口腔表面提供有利于所述口腔护理剂活化的pH环境。
7.权利要求6的方法,其中所述口腔护理剂为过氧化合物,且其中所述pH调节剂为碱化剂。
8.权利要求7的方法,其中所述碱化剂为碱金属碳酸盐或碳酸氢盐。
9.权利要求7的方法,其中所述碱化剂为碳酸氢钠。
10.一种使牙齿表面增白的方法,所述方法包括用吸收性织物擦拭表面,该吸收性织物中已浸渍或其上涂覆口腔可接受的碱化剂,其后将包含口腔可接受的过氧化合物的组合物施用于所述表面。
11.权利要求10的方法,其中所述吸收性织物为拭巾形式。
12.权利要求10的方法,其中所述吸收性织物还含有香料。
13.权利要求10的方法,其中所述碱化剂为碱金属碳酸盐或碳酸氢盐。
14.权利要求10的方法,其中所述碱化剂为碳酸氢钠。
15.权利要求10的方法,其中所述过氧化合物选自过氧化氢、碱金属和碱土金属的过氧化物、有机过氧化合物、过氧酸及其盐和聚合物-过氧化物复合物。
16.权利要求10的方法,其中所述过氧化合物为过氧化氢。
17.权利要求10的方法,其中所述包含过氧化合物的组合物为增白带。
18.权利要求10的方法,其中所述包含过氧化合物的组合物为液体增白剂。
19.权利要求10的方法,其中所述包含过氧化合物的组合物为半固体洁齿剂。
20.一种用于口腔护理的药剂盒,所述药剂盒包含(a)包含口腔护理剂的组合物,和(b)其中已浸渍或其上涂覆口腔可接受的预处理剂的吸收性织物。
21.权利要求20的药剂盒,其中所述预处理剂为所述口腔护理剂的活化剂。
22.权利要求20的药剂盒,其中所述吸收性织物为拭巾形式。
23.权利要求20的药剂盒,其中所述吸收性织物还含有香料。
24.权利要求20的药剂盒,其中所述口腔护理剂为口腔可接受的过氧化合物,且所述预处理剂为碱化剂。
25.权利要求24的药剂盒,其中所述碱化剂为碱金属碳酸盐或碳酸氢盐。
26.权利要求24的药剂盒,其中所述碱化剂为碳酸氢钠。
27.权利要求24的药剂盒,其中所述过氧化合物选自过氧化氢、碱金属和碱土金属的过氧化物、有机过氧化合物、过氧酸及其盐和聚合物-过氧化物复合物。
28.权利要求24的药剂盒,其中所述过氧化合物为过氧化氢。
29.权利要求24的药剂盒,其中所述包含过氧化合物的组合物为增白带。
30.权利要求24的药剂盒,其中所述包含过氧化合物的组合物为液体增白剂。
31.权利要求24的药剂盒,其中所述包含过氧化合物的组合物为半固体洁齿剂。
32.一种用于将增白处理的牙齿表面预处理的物品,所述物品包含润湿拭巾,该拭巾载有有效量的口腔可接受碱化剂的水溶液,当用该拭巾擦拭表面时,该有效量在牙齿表面提供至少约7的pH。
33.权利要求32的物品,其中所述碱化剂为碳酸氢钠。
34.权利要求32的物品,其中所述拭巾还含有香料。
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US10/811,723 | 2004-03-29 | ||
US10/811,723 US20050210615A1 (en) | 2004-03-29 | 2004-03-29 | Oral care method |
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US (1) | US20050210615A1 (zh) |
EP (1) | EP1744721A1 (zh) |
CN (1) | CN1960701A (zh) |
AR (1) | AR048115A1 (zh) |
AU (1) | AU2005229069A1 (zh) |
BR (1) | BRPI0509481A (zh) |
CA (1) | CA2559727A1 (zh) |
RU (1) | RU2006138059A (zh) |
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CN102353669A (zh) * | 2011-06-16 | 2012-02-15 | 占春瑞 | 烟花爆竹药剂中氯酸盐快速检测试剂及方法 |
CN104394937A (zh) * | 2011-12-19 | 2015-03-04 | 高露洁-棕榄公司 | 液体活化*** |
CN104394937B (zh) * | 2011-12-19 | 2017-09-22 | 高露洁-棕榄公司 | 液体活化*** |
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BRPI0509481A (pt) | 2007-09-11 |
AU2005229069A1 (en) | 2005-10-13 |
RU2006138059A (ru) | 2008-05-10 |
US20050210615A1 (en) | 2005-09-29 |
WO2005094766A1 (en) | 2005-10-13 |
CA2559727A1 (en) | 2005-10-13 |
AR048115A1 (es) | 2006-03-29 |
TW200600112A (en) | 2006-01-01 |
ZA200607758B (en) | 2008-05-28 |
EP1744721A1 (en) | 2007-01-24 |
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