CN1947800A - Hemostatic particles and preparation method thereof - Google Patents
Hemostatic particles and preparation method thereof Download PDFInfo
- Publication number
- CN1947800A CN1947800A CN 200610053680 CN200610053680A CN1947800A CN 1947800 A CN1947800 A CN 1947800A CN 200610053680 CN200610053680 CN 200610053680 CN 200610053680 A CN200610053680 A CN 200610053680A CN 1947800 A CN1947800 A CN 1947800A
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- Prior art keywords
- starch
- hemostatic
- solution
- preparation
- granules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 239000002245 particle Substances 0.000 title claims abstract description 7
- 229920002472 Starch Polymers 0.000 claims abstract description 30
- 239000008107 starch Substances 0.000 claims abstract description 30
- 235000019698 starch Nutrition 0.000 claims abstract description 22
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920001592 potato starch Polymers 0.000 claims abstract description 13
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims abstract description 9
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000004676 glycans Chemical class 0.000 claims abstract description 7
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 7
- 239000005017 polysaccharide Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000005662 Paraffin oil Substances 0.000 claims abstract description 5
- 238000004132 cross linking Methods 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 36
- 238000003756 stirring Methods 0.000 claims description 23
- 239000008187 granular material Substances 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000011259 mixed solution Substances 0.000 claims description 8
- 239000012188 paraffin wax Substances 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 4
- 239000012153 distilled water Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 4
- 229940057995 liquid paraffin Drugs 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- -1 liquid paraffin Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 238000003828 vacuum filtration Methods 0.000 claims description 2
- 208000032843 Hemorrhage Diseases 0.000 abstract description 14
- 210000004369 blood Anatomy 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000012798 spherical particle Substances 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 230000023597 hemostasis Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 5
- 230000000025 haemostatic effect Effects 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 108090000190 Thrombin Proteins 0.000 description 3
- 239000004531 microgranule Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 231100000957 no side effect Toxicity 0.000 description 3
- 229960004072 thrombin Drugs 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 2
- 108010073385 Fibrin Proteins 0.000 description 2
- 102000009123 Fibrin Human genes 0.000 description 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 229950003499 fibrin Drugs 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- FBPFZTCFMRRESA-ZXXMMSQZSA-N D-iditol Chemical compound OC[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-ZXXMMSQZSA-N 0.000 description 1
- 108010080379 Fibrin Tissue Adhesive Proteins 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 101710185622 Pyrrolidone-carboxylate peptidase Proteins 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000009455 aseptic packaging Methods 0.000 description 1
- 230000008952 bacterial invasion Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100536809A CN100453122C (en) | 2006-09-29 | 2006-09-29 | Hemostatic particles and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2006100536809A CN100453122C (en) | 2006-09-29 | 2006-09-29 | Hemostatic particles and preparation method thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1947800A true CN1947800A (en) | 2007-04-18 |
CN100453122C CN100453122C (en) | 2009-01-21 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB2006100536809A Active CN100453122C (en) | 2006-09-29 | 2006-09-29 | Hemostatic particles and preparation method thereof |
Country Status (1)
Country | Link |
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CN (1) | CN100453122C (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102139123A (en) * | 2011-03-25 | 2011-08-03 | 杜宝堂 | Method for preparing intra-operative hemostatic material by cross emulsification of plant starch |
CN102302796A (en) * | 2011-09-08 | 2012-01-04 | 江苏天麟生物医药科技有限公司 | Absorptive hemostatic biological material and preparation method thereof |
CN102406956A (en) * | 2011-03-09 | 2012-04-11 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
CN101361986B (en) * | 2007-08-09 | 2013-06-05 | 纪欣 | Modified starch absorbable or biocompatible hemostasia material and preparation method thereof |
CN104225662A (en) * | 2014-09-28 | 2014-12-24 | 沈丽青 | Hemostatic product and preparation method thereof |
CN104274486A (en) * | 2013-09-03 | 2015-01-14 | 江西丽华鑫朗药业科技有限公司 | Composite biodegradable styptic powder prepared by sodium hyaluronate |
CN104606723A (en) * | 2014-12-12 | 2015-05-13 | 重庆联佰博超医疗器械有限公司 | Absorbable starch bleeding-stopping powder, and preparation method and application thereof |
CN105597143A (en) * | 2016-02-01 | 2016-05-25 | 山东省药学科学院 | Method for preparing styptic powder by pure aqueous phase |
CN105688265A (en) * | 2016-01-22 | 2016-06-22 | 青岛中腾生物技术有限公司 | Absorbable hemostatic material as well as preparation method and use thereof |
CN105920662A (en) * | 2016-05-25 | 2016-09-07 | 重庆联佰博超医疗器械有限公司 | Absorbable wound buffer dressing |
CN105920661A (en) * | 2016-05-25 | 2016-09-07 | 重庆联佰博超医疗器械有限公司 | Absorbable wound buffering dressing |
CN106073992A (en) * | 2016-05-25 | 2016-11-09 | 重庆联佰博超医疗器械有限公司 | The buffering dressing of absorbability composite wound |
CN106955375A (en) * | 2016-12-07 | 2017-07-18 | 凯文蔡司淀粉科技有限公司 | A kind of medical treatment device for including plant polysaccharide stopped blooding for Minimally Invasive Surgery |
CN107802881A (en) * | 2016-12-07 | 2018-03-16 | 海南美享医药科技有限公司 | A kind of plant polysaccharide with anastalsis and preparation method thereof |
CN108434510A (en) * | 2018-05-23 | 2018-08-24 | 宁波宝亭生物科技有限公司 | A kind of preparation method of modified starch hemostatic microsphere |
CN108815564A (en) * | 2018-07-25 | 2018-11-16 | 青岛琛蓝海洋生物工程有限公司 | A kind of starch base styptic powder and preparation method thereof |
CN110665049A (en) * | 2019-10-25 | 2020-01-10 | 石家庄亿生堂医用品有限公司 | Method for preparing hemostatic starch microspheres by ultrasonic |
CN112843324A (en) * | 2021-01-13 | 2021-05-28 | 山东省药学科学院 | Preparation method of rapidly degradable hemostatic powder |
CN115154645A (en) * | 2022-08-23 | 2022-10-11 | 赛克赛斯生物科技股份有限公司 | Antibacterial hemostatic material, preparation method and application thereof, and medical material |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2783429B1 (en) * | 1998-09-18 | 2002-04-12 | Imedex Biomateriaux | BICOMPOSITE COLLAGENIC MATERIAL, ITS OBTAINING PROCESS AND ITS THERAPEUTIC APPLICATIONS |
AU2002361902A1 (en) * | 2001-12-31 | 2003-07-24 | Ares Medical, Inc. | Hemostatic compositions and methods for controlling bleeding |
US7019191B2 (en) * | 2003-03-25 | 2006-03-28 | Ethicon, Inc. | Hemostatic wound dressings and methods of making same |
US20040241212A1 (en) * | 2003-05-30 | 2004-12-02 | Pendharkar Sanyog Manohar | Biodegradable hemostatic wound dressings |
CA2530032C (en) * | 2003-06-16 | 2015-11-24 | Loma Linda University Medical Center | Deployable multifunctional hemostatic agent |
-
2006
- 2006-09-29 CN CNB2006100536809A patent/CN100453122C/en active Active
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101361986B (en) * | 2007-08-09 | 2013-06-05 | 纪欣 | Modified starch absorbable or biocompatible hemostasia material and preparation method thereof |
CN102406956A (en) * | 2011-03-09 | 2012-04-11 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
CN102406956B (en) * | 2011-03-09 | 2013-09-25 | 天津爱勒易医药材料有限公司 | Starch hemostatic microsphere and preparation method thereof |
CN102139123A (en) * | 2011-03-25 | 2011-08-03 | 杜宝堂 | Method for preparing intra-operative hemostatic material by cross emulsification of plant starch |
CN102139123B (en) * | 2011-03-25 | 2013-07-17 | 杜宝堂 | Method for preparing intra-operative hemostatic material by cross emulsification of plant starch |
CN102302796A (en) * | 2011-09-08 | 2012-01-04 | 江苏天麟生物医药科技有限公司 | Absorptive hemostatic biological material and preparation method thereof |
CN102302796B (en) * | 2011-09-08 | 2015-04-15 | 江苏天麟生物医药科技有限公司 | Absorptive hemostatic biological material and preparation method thereof |
CN104274486A (en) * | 2013-09-03 | 2015-01-14 | 江西丽华鑫朗药业科技有限公司 | Composite biodegradable styptic powder prepared by sodium hyaluronate |
CN104225662A (en) * | 2014-09-28 | 2014-12-24 | 沈丽青 | Hemostatic product and preparation method thereof |
CN104225662B (en) * | 2014-09-28 | 2016-03-23 | 沈丽青 | Hemostasia products and preparation method thereof |
CN104606723A (en) * | 2014-12-12 | 2015-05-13 | 重庆联佰博超医疗器械有限公司 | Absorbable starch bleeding-stopping powder, and preparation method and application thereof |
CN105688265A (en) * | 2016-01-22 | 2016-06-22 | 青岛中腾生物技术有限公司 | Absorbable hemostatic material as well as preparation method and use thereof |
CN105597143B (en) * | 2016-02-01 | 2018-12-18 | 山东省药学科学院 | A kind of method that pure water mutually prepares styptic powder |
CN105597143A (en) * | 2016-02-01 | 2016-05-25 | 山东省药学科学院 | Method for preparing styptic powder by pure aqueous phase |
CN105920662A (en) * | 2016-05-25 | 2016-09-07 | 重庆联佰博超医疗器械有限公司 | Absorbable wound buffer dressing |
CN105920661A (en) * | 2016-05-25 | 2016-09-07 | 重庆联佰博超医疗器械有限公司 | Absorbable wound buffering dressing |
CN106073992A (en) * | 2016-05-25 | 2016-11-09 | 重庆联佰博超医疗器械有限公司 | The buffering dressing of absorbability composite wound |
CN106955375A (en) * | 2016-12-07 | 2017-07-18 | 凯文蔡司淀粉科技有限公司 | A kind of medical treatment device for including plant polysaccharide stopped blooding for Minimally Invasive Surgery |
CN107802881A (en) * | 2016-12-07 | 2018-03-16 | 海南美享医药科技有限公司 | A kind of plant polysaccharide with anastalsis and preparation method thereof |
CN108434510A (en) * | 2018-05-23 | 2018-08-24 | 宁波宝亭生物科技有限公司 | A kind of preparation method of modified starch hemostatic microsphere |
CN108434510B (en) * | 2018-05-23 | 2021-03-02 | 宁波宝亭生物科技有限公司 | Preparation method of modified starch hemostatic microspheres |
CN108815564A (en) * | 2018-07-25 | 2018-11-16 | 青岛琛蓝海洋生物工程有限公司 | A kind of starch base styptic powder and preparation method thereof |
CN110665049A (en) * | 2019-10-25 | 2020-01-10 | 石家庄亿生堂医用品有限公司 | Method for preparing hemostatic starch microspheres by ultrasonic |
CN110665049B (en) * | 2019-10-25 | 2022-02-01 | 石家庄亿生堂医用品有限公司 | Method for preparing hemostatic starch microspheres by ultrasonic |
CN112843324A (en) * | 2021-01-13 | 2021-05-28 | 山东省药学科学院 | Preparation method of rapidly degradable hemostatic powder |
CN115154645A (en) * | 2022-08-23 | 2022-10-11 | 赛克赛斯生物科技股份有限公司 | Antibacterial hemostatic material, preparation method and application thereof, and medical material |
CN115154645B (en) * | 2022-08-23 | 2023-09-26 | 赛克赛斯生物科技股份有限公司 | Antibacterial hemostatic material, preparation method and application thereof, and medical material |
Also Published As
Publication number | Publication date |
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CN100453122C (en) | 2009-01-21 |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Hangzhou Singclean Medical Products Co., Ltd. Assignor: Shen Jing Contract record no.: 2010330001603 Denomination of invention: Hemostatic micro-granules and its prepn. method Granted publication date: 20090121 License type: Exclusive License Open date: 20070418 Record date: 20100809 |
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C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20160830 Address after: 311215, No. 10, East (125) Street, Xiasha economic and Technological Development Zone, Hangzhou, Zhejiang Patentee after: Hangzhou Singclean Medical Products Co., Ltd. Address before: 311402 Gaoqiao Industrial Park (Hefeng), Fuyang, Zhejiang Patentee before: Shen Jing |