CN1913872A - 潮湿敏感药物的预定量干粉吸入剂 - Google Patents
潮湿敏感药物的预定量干粉吸入剂 Download PDFInfo
- Publication number
- CN1913872A CN1913872A CNA2004800412129A CN200480041212A CN1913872A CN 1913872 A CN1913872 A CN 1913872A CN A2004800412129 A CNA2004800412129 A CN A2004800412129A CN 200480041212 A CN200480041212 A CN 200480041212A CN 1913872 A CN1913872 A CN 1913872A
- Authority
- CN
- China
- Prior art keywords
- dry powder
- excipient
- powder inhaler
- container
- dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Packages (AREA)
- Materials For Medical Uses (AREA)
- Table Devices Or Equipment (AREA)
- Containers Having Bodies Formed In One Piece (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
计算基于 | 在HandiHaler中的Spiriva,商品样品,FPD | 在C-haler中的Spiriva,FPD |
定量剂量 | 18% | 47% |
释放剂量 | 36% | 56% |
Claims (19)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0303269-5 | 2003-12-03 | ||
SE0303269A SE0303269L (sv) | 2003-12-03 | 2003-12-03 | Medicinsk produkt |
SE03032695 | 2003-12-03 | ||
SE03035698 | 2003-12-22 | ||
SE0303569-8 | 2003-12-22 | ||
SE0303569A SE0303569L (sv) | 2003-12-03 | 2003-12-22 | DPI för avlämning av fuktkänsliga medikament |
US10/933219 | 2004-09-03 | ||
US10/933,219 US20050121032A1 (en) | 2003-12-03 | 2004-09-03 | Pre-metered dry powder inhaler for moisture-sensitive medicaments |
PCT/SE2004/001794 WO2005053648A1 (en) | 2003-12-03 | 2004-12-02 | Pre-metered dry powder inhaler for moisture-sensitive medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1913872A true CN1913872A (zh) | 2007-02-14 |
CN1913872B CN1913872B (zh) | 2011-05-25 |
Family
ID=29778162
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800412129A Active CN1913872B (zh) | 2003-12-03 | 2004-12-02 | 潮湿敏感药物的预定量干粉吸入器 |
CN2004800413545A Active CN1913873B (zh) | 2003-12-03 | 2004-12-02 | 包含装在防水容器中的tiotropium的医学产品 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2004800413545A Active CN1913873B (zh) | 2003-12-03 | 2004-12-02 | 包含装在防水容器中的tiotropium的医学产品 |
Country Status (25)
Country | Link |
---|---|
US (4) | US20050124644A1 (zh) |
EP (1) | EP1706099B1 (zh) |
JP (1) | JP2007513152A (zh) |
KR (1) | KR101124071B1 (zh) |
CN (2) | CN1913872B (zh) |
AT (1) | ATE507821T1 (zh) |
AU (1) | AU2004294886B2 (zh) |
BR (1) | BRPI0417155A (zh) |
CA (1) | CA2547781A1 (zh) |
CY (1) | CY1111735T1 (zh) |
DE (1) | DE602004032575D1 (zh) |
DK (1) | DK1706099T3 (zh) |
ES (1) | ES2362750T3 (zh) |
HK (1) | HK1100643A1 (zh) |
IL (1) | IL175887A (zh) |
MX (1) | MXPA06006238A (zh) |
NZ (1) | NZ547905A (zh) |
PL (1) | PL1706099T3 (zh) |
PT (1) | PT1706099E (zh) |
RU (1) | RU2369385C2 (zh) |
SE (1) | SE0303269L (zh) |
SG (1) | SG148206A1 (zh) |
SI (1) | SI1706099T1 (zh) |
WO (1) | WO2005053644A1 (zh) |
ZA (4) | ZA200605380B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110833539A (zh) * | 2012-11-09 | 2020-02-25 | 丝维塔斯治疗公司 | 超低密度的肺部粉末 |
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US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US7080644B2 (en) | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
EP1894591B1 (en) | 2002-03-20 | 2013-06-26 | MannKind Corporation | Cartridge for an inhalation apparatus |
SE0303571D0 (sv) * | 2003-12-03 | 2003-12-22 | Microdrug Ag | Medical product for moisture-sensitive medicaments |
SE0303269L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Medicinsk produkt |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
SE0303270L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
SE0303569L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | DPI för avlämning av fuktkänsliga medikament |
AU2004294889B2 (en) * | 2003-12-03 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Medical product containing tiotropium |
PL1691783T3 (pl) * | 2003-12-03 | 2010-05-31 | Boehringer Ingelheim Int | Inhalator suchego proszku ze wstępnym odmierzaniem do leków wrażliwych na wilgoć |
MXPA06009516A (es) | 2004-02-24 | 2007-03-26 | Microdose Technologies Inc | Inhalador con sensor de flujo direccional. |
CA2575692C (en) | 2004-08-20 | 2014-10-14 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
ES2540853T3 (es) | 2004-08-23 | 2015-07-14 | Mannkind Corporation | Sales de dicetopiperazina para la administración de fármacos |
TWI274641B (en) * | 2005-08-30 | 2007-03-01 | Rexon Ind Corp Ltd | Cutting machine |
JP5167133B2 (ja) | 2005-09-14 | 2013-03-21 | マンカインド コーポレイション | 結晶性微粒子表面に対する活性薬剤の親和性の増大に基づく薬物処方の方法 |
EP2497484A3 (en) | 2006-02-22 | 2012-11-07 | MannKind Corporation | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US8415390B2 (en) | 2008-05-30 | 2013-04-09 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
US9119777B2 (en) | 2008-05-30 | 2015-09-01 | Microdose Therapeutx, Inc. | Methods and compositions for administration of oxybutynin |
US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
US8371294B2 (en) | 2008-02-29 | 2013-02-12 | Microdose Therapeutx, Inc. | Method and apparatus for driving a transducer of an inhalation device |
KR101672684B1 (ko) | 2008-06-13 | 2016-11-03 | 맨카인드 코포레이션 | 건조 분말 흡입기 및 약물 투여 시스템 |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
CA2728523C (en) | 2008-06-20 | 2020-03-10 | Mannkind Corporation | An interactive apparatus and method for real-time profiling of inhalation efforts |
TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
ES2739352T3 (es) | 2009-02-26 | 2020-01-30 | Glaxo Group Ltd | Formulaciones farmacéuticas que comprenden 4-{(1R)-2-[(6-{2-[(2,6-diclorobencil)oxi]etoxi}hexil)amino]-1-hidroxietil}-2-(hidroximetil)fenol |
CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US8985101B2 (en) | 2009-05-21 | 2015-03-24 | Microdose Therapeutx, Inc. | Method and device for clamping a blister within a dry powder inhaler |
AU2010249402B2 (en) | 2009-05-21 | 2014-08-21 | Microdose Therapeutx, Inc. | Rotary cassette system for dry powder inhaler |
BRPI1013154B1 (pt) | 2009-06-12 | 2020-04-07 | Mannkind Corp | Micropartículas de dicetopiperazina com áreas de superfície específicas definidas, pó seco compreendendo as referidas micropartículas, método para formação das referidasmicropartículas e formação de micropartículas de fumaril diacetopiperazina, uso das referidas micropartículas e sistema de inalação |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
CN105381524A (zh) | 2010-01-05 | 2016-03-09 | 微剂量治疗技术公司 | 吸入设备和方法 |
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WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
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CN108057154B (zh) | 2012-07-12 | 2021-04-16 | 曼金德公司 | 干粉药物输送***和方法 |
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EP3587404B1 (en) | 2013-03-15 | 2022-07-13 | MannKind Corporation | Microcrystalline diketopiperazine compositions, methods for preparation and use thereof |
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US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
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PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
GB0015043D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Medicament dispenser |
SE517227C2 (sv) | 2000-09-25 | 2002-05-14 | Microdrug Ag | Inhalator för torrt pulver med folieskärare |
JP3870159B2 (ja) * | 2000-10-12 | 2007-01-17 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | チオトロピウムを含む新規吸入性粉剤 |
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DE10126924A1 (de) * | 2001-06-01 | 2002-12-05 | Boehringer Ingelheim Pharma | Inhalationskapseln |
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UA80123C2 (en) | 2002-04-09 | 2007-08-27 | Boehringer Ingelheim Pharma | Inhalation kit comprising inhalable powder of tiotropium |
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SE525027C2 (sv) * | 2002-04-12 | 2004-11-16 | Microdrug Ag | Anordning utgörande en pulverlufthyvel |
SE524957C2 (sv) * | 2002-04-12 | 2004-11-02 | Microdrug Ag | Förfarande för uppdelning och fördelning i luft av torrt pulvermedikament |
SE524990C2 (sv) * | 2002-04-12 | 2004-11-09 | Microdrug Ag | Preparation av terapeutiskt torrt pulver samt förfarande för uppdelning och spridning i luft av medicinskt pulver |
GB0225621D0 (en) * | 2002-11-02 | 2002-12-11 | Glaxo Group Ltd | Medicament carrier |
CN1292748C (zh) * | 2003-03-05 | 2007-01-03 | 南昌弘益科技有限公司 | 噻托溴铵吸入粉雾剂及其制备工艺 |
US20050055014A1 (en) * | 2003-08-04 | 2005-03-10 | Coppeta Jonathan R. | Methods for accelerated release of material from a reservoir device |
SE0303270L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Metod för administration av tiotropium |
SE0303570L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Fukt-känslig medicinsk produkt |
SE0303571D0 (sv) * | 2003-12-03 | 2003-12-22 | Microdrug Ag | Medical product for moisture-sensitive medicaments |
SE0303569L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | DPI för avlämning av fuktkänsliga medikament |
SE0303269L (sv) * | 2003-12-03 | 2005-06-04 | Microdrug Ag | Medicinsk produkt |
-
2003
- 2003-12-03 SE SE0303269A patent/SE0303269L/sv unknown
- 2003-12-08 US US10/728,986 patent/US20050124644A1/en not_active Abandoned
-
2004
- 2004-12-02 EP EP04801707A patent/EP1706099B1/en not_active Revoked
- 2004-12-02 JP JP2006542535A patent/JP2007513152A/ja active Pending
- 2004-12-02 CA CA002547781A patent/CA2547781A1/en not_active Abandoned
- 2004-12-02 CN CN2004800412129A patent/CN1913872B/zh active Active
- 2004-12-02 ES ES04801707T patent/ES2362750T3/es active Active
- 2004-12-02 PL PL04801707T patent/PL1706099T3/pl unknown
- 2004-12-02 PT PT04801707T patent/PT1706099E/pt unknown
- 2004-12-02 ZA ZA200605380A patent/ZA200605380B/en unknown
- 2004-12-02 NZ NZ547905A patent/NZ547905A/en unknown
- 2004-12-02 AU AU2004294886A patent/AU2004294886B2/en active Active
- 2004-12-02 SI SI200431694T patent/SI1706099T1/sl unknown
- 2004-12-02 MX MXPA06006238A patent/MXPA06006238A/es active IP Right Grant
- 2004-12-02 WO PCT/SE2004/001790 patent/WO2005053644A1/en active Application Filing
- 2004-12-02 DK DK04801707.3T patent/DK1706099T3/da active
- 2004-12-02 KR KR1020067011729A patent/KR101124071B1/ko active IP Right Grant
- 2004-12-02 SG SG200808774-4A patent/SG148206A1/en unknown
- 2004-12-02 AT AT04801707T patent/ATE507821T1/de active
- 2004-12-02 RU RU2006122849/15A patent/RU2369385C2/ru active
- 2004-12-02 ZA ZA200604616A patent/ZA200604616B/xx unknown
- 2004-12-02 ZA ZA200605379A patent/ZA200605379B/en unknown
- 2004-12-02 BR BRPI0417155-1A patent/BRPI0417155A/pt not_active Application Discontinuation
- 2004-12-02 DE DE602004032575T patent/DE602004032575D1/de active Active
- 2004-12-02 CN CN2004800413545A patent/CN1913873B/zh active Active
- 2004-12-02 ZA ZA200604618A patent/ZA200604618B/xx unknown
-
2006
- 2006-05-24 IL IL175887A patent/IL175887A/en active IP Right Grant
- 2006-06-08 US US11/448,773 patent/US20060257327A1/en not_active Abandoned
-
2007
- 2007-08-03 HK HK07108468.9A patent/HK1100643A1/xx unknown
-
2008
- 2008-10-21 US US12/255,086 patent/US20090041682A1/en not_active Abandoned
-
2009
- 2009-04-03 US US12/417,814 patent/US20090192185A1/en not_active Abandoned
-
2011
- 2011-07-22 CY CY20111100727T patent/CY1111735T1/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110833539A (zh) * | 2012-11-09 | 2020-02-25 | 丝维塔斯治疗公司 | 超低密度的肺部粉末 |
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US20070020198A1 (en) | Medical product containing tiotropium |
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