CN1895471A - Chinese-medicinal jet embrocation for healing wound and its preparation - Google Patents
Chinese-medicinal jet embrocation for healing wound and its preparation Download PDFInfo
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- CN1895471A CN1895471A CNA2006100869563A CN200610086956A CN1895471A CN 1895471 A CN1895471 A CN 1895471A CN A2006100869563 A CNA2006100869563 A CN A2006100869563A CN 200610086956 A CN200610086956 A CN 200610086956A CN 1895471 A CN1895471 A CN 1895471A
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- borneolum syntheticum
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Abstract
A Chinese medicine in the form of spray liniment for fast healing of wound without scar is prepared from 18 Chinese-medicinal materials including coptis root, astragalus root, scutellaria root, flavescent sophora root, etc through rinsing, pulverizing, dispensing and filtering.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relating to a kind of is raw material with the Chinese herbal medicine, is used for the treatment of diseases such as burn, herpes, skin ulcer, but and has Chinese medicine liniment spray of antibiotic analgesic antiphlogistic quickly-healing wound and preparation method thereof.
Technical background
Since founding the state, follow economical development at full speed and progress of science and technology, the clinical treatment level of China progressively reaches rank first.But, be difficult to find that a kind of product can cicatrize a wound fast, the problem of anti-inflammatory analgetic for various burn and scald patients, long-term wound patient and suffer from various dermatosis patients more.
July 25 calendar year 2001 on the Chinese patent communique Granted publication a kind of patent of invention number be the patent of 98110254.9 " a kind of external Chinese patent medicine that is used for the treatment of diseases such as scald, burn, skin ulcer ", it provides a kind of Chinese patent medicine powder of being made up of dried Alumen, Radix Et Rhizoma Rhei, Gypsum Fibrosum Preparatum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Olibanum, Myrrha, though it has reducing swelling and alleviating pain, arresting hemostasia and suppuration, activating blood circulation to dissipate blood stasis, the no scar in back heals, but its manufacture method more complicated, the healing cycle is long.
Summary of the invention
In order to overcome the deficiencies in the prior art, the purpose of this invention is to provide a kind of is raw material with the Chinese herbal medicine, but the cure rate height, has no side effect and have the Chinese medicine liniment spray of antibiotic analgesic antiphlogistic quickly-healing wound.
Another object of the present invention provides a kind of this liniment spray preparation of drug combination method.
The object of the present invention is achieved like this: but a kind of Chinese medicine liniment spray of quickly-healing wound, form by Rhizoma Polygoni Cuspidati, Rhizoma Coptidis, Cortex Phellodendri, the Radix Astragali, Radix Scutellariae, catechu, SHANZHIZI, Radix Sophorae Flavescentis, Fructus Evodiae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi), Radix Sanguisorbae, Radix Ampelopsis, Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum Chinese crude drug, according to listed as parts by weight, the drug component of this Chinese medicine liniment spray is:
Rhizoma Polygoni Cuspidati 100～180, Rhizoma Coptidis 50～120, Cortex Phellodendri 50～120,
The Radix Astragali 50～100, Radix Scutellariae 50～100, catechu 30～80,
SHANZHIZI 30～50, Radix Sophorae Flavescentis 30～50, Fructus Evodiae 30～50,
Radix Et Rhizoma Rhei 30～50, Radix Arnebiae (Radix Lithospermi) 30～50, Radix Sanguisorbae 20～40,
Radix Ampelopsis 20～40, Galla Chinensis 10～30, Olibanum 10～30,
Myrrha 10～30, Fructus Schisandrae Chinensis 10～30, Borneolum Syntheticum 80～150.
Optimum weight part proportioning of pharmaceutical composition of the present invention is:
Rhizoma Polygoni Cuspidati 140, Rhizoma Coptidis 110, Cortex Phellodendri 110, the Radix Astragali 75, Radix Scutellariae 75,
Catechu 55, SHANZHIZI 40, Radix Sophorae Flavescentis 40, Fructus Evodiae 40, Radix Et Rhizoma Rhei 40,
Radix Arnebiae (Radix Lithospermi) 40, Radix Sanguisorbae 30, Radix Ampelopsis 30, Galla Chinensis 20, Olibanum 20,
Myrrha 20, Fructus Schisandrae Chinensis 20, Borneolum Syntheticum 115.
What the pharmaceutical dosage form of pharmaceutical composition of the present invention adopted is liniment spray, also can adopt any medically said dosage form.
The preparation method of pharmaceutical composition liniment spray of the present invention is:
1. rinsing: with above-mentioned 18 flavor Chinese crude drugs select, rinsing, dry in the sun.
2. pulverize: the medical material after drying, pulverize according to the weight portion back of weighing, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis are crossed 50 mesh sieve, in the container bag of packing into, standby; Except that Borneolum Syntheticum, remaining 13 flavor Chinese crude drug is crossed 30 mesh sieve, in another container bag of packing into then, standby.
3. make liquid: Borneolum Syntheticum is dissolved in fills in 95% the alcoholic solution, according to 1: 500ml ratio obtain solution.
4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the ethanol that contains Borneolum Syntheticum mix in the hermetic container of liquid, placed 7～10 days, temperature remains in 25～35 degrees centigrade indoor.Put into the hermetic container of the mixed liquid of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, placed 10～20 days again, temperature remains in 20～30 degrees centigrade indoor.
5. test: detect bases, glycoside with the reagent paper chromatography; Observe solution colour then, as be dark brown, get final product filtering solution.
6. filter: will be the dark brown mixed solution and filter with 30～50 mesh sieves, and wait post precipitation reuse 50～70 mesh sieves to filter, the solution after the filtration is placed in the container of sealing lucifuge, can use.
The above Chinese liquor of also available 60 degree of solution in the preparation of the present invention substitutes, and operates according to above-mentioned pharmacy step, and it is 35～50 degrees centigrade, 20～40 days by a definite date that the solution that fills medicine is placed on room temperature, can finish whole process of preparation.
Finished product of the present invention is auburn water formulation.
During use, the situation impaired according to wound, spray is wiped and is got final product.
Pharmaceutical composition of the present invention not only has reducing swelling and alleviating pain, antimicrobial antiphlogistic, removing the necrotic tissue and promoting granulation, sterilizing and itch-relieving, and can activating blood circulation to dissipate blood stasis, arresting hemostasia and suppuration, the no cicatrix in back more.
The effect of the Chinese medicine ingredients of liniment spray pharmaceutical composition of the present invention is:
1, Rhizoma Polygoni Cuspidati:
Another name is bitter cane, sour cane, speckle cane, acid bucket Radix Crotalariae szemoensis, speckle Zhuan Gen etc.
Main component: root and rhizome contain dissociated anthraquinone and anthraquinone glycoside.Root hydroxyl anthraquinone is mainly emodin, physcione and chrysophanol, and anthracene glycoside A, i.e. physcione 8-β-D-glycoside, anthracene glycoside B, i.e. emodin.Other contains tannin and several polysaccharide.Stem contains tannin 3.3%, Isoquercitrin, emodin etc.Withe contains tannin 13.4%.The sour leaf of tender stem is mainly oxalic acid etc.Still contain diphenylethylene compounds: resvertrol, resvertrol glycoside also contain multiple polysaccharide and condensed tannin.Other gets a noval chemical compound 2-methoxyl group-6-acetonyl juglone.The property feeble QI, mildly bitter flavor.
Have heat-clearing and toxic substances removing, clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, the analgesic therapy of invigorating blood circulation, clearing away heat-damp and promoting diuresis, heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing etc.Be mainly used in treatment rheumatism bones and muscles pain, jaundice due to damp-heat, the stranguria with turbid discharge leukorrhagia, abdominal mass is gathered, the anal fistula hematochezia, injury from falling down is scalded malignant boil tinea disease etc.
2, Rhizoma Coptidis:
Another name is Wang Lian, Zhi Lian, flavor company, Rhizoma Coptidis, Rhizoma Coptidis, chicken feet Rhizoma Coptidis etc.
Main component: the rhizome master contains berberine 5%-8%, also contains coptisine, 13-methyl-.psi.-coptisine., palmatine, jateorhizine, table coptisine and the little wall alkali of 5-hydroxyl etc.; Because they have analog structure, often are referred to as Rhizoma Coptidis alkaloid.In addition, still contain magnoline and ferulic acid, chlorogenic acid etc.
Feeble QI, flavor are extremely bitter.
Have clearing away heat-fire detoxifcation, heat clearing and damp drying, the relieving restlessness that clears away heart-fire, clearing away heat to stop bleeding, being used for fire, to contain the haematemesis of the absurd row of forcing blood, epistaxis etc. hemorrhage.
Cure mainly: row pyretic toxicity when controlling, typhoid fever, intenseness of heat is vexed, the feeling of fullness vomiting, bacillary dysentery, diarrhea of heat type stomachache, pulmonary tuberculosis is told, nosebleed, hematochezia, quenches one's thirst infantile malnutrition, ascariasis, pertussis, laryngopharynx swelling and pain, acute catarrhal conjunctivitis, aphtha, skin sore, eczema, the burning hot wound of soup.
3, Cortex Phellodendri:
Another name is: bark of a cork tree wood, bark of a cork tree skin, Cortex Phellodendri, yellow POLO, Huang Baili, wampee etc.
Main component: it is about 1.6% that 1) Cortex Phellodendri contains berberine, and contain a small amount of phellodendrine, magnoline, jateorhizine, palmatine, candicine, Caulis menispermi and appoint alkali; Other contains limonin and obacunone.Also have γ-and cupreol, stigmasterol, 7-Dehydrostigmaslerol etc.It is about 9% that root bark is isolated berberine, and jateorhizine, phellodendrine, candicine are still arranged.2) the wampee bark contains berberine and reaches 3%.3) bald leaf wampee bark contains berberine and reaches 6.5%, and contains a small amount of palmatine, jateorhizine, phellodendrine, magnoline and cupreol etc.
Feeble QI, flavor are very bitter.
Have clearing away heat-fire detoxifcation, heat clearing and damp drying, rush down the kidney fire.
Cure mainly: control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice, flaccidity, nocturnal emission, stranguria with turbid discharge, hemorrhoid are had blood in stool, leucorrhea with red and white discharge, hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.
4, the Radix Astragali:
Another name is: wear crushed grain, wear mulberry, solely mulberry, another name for Sichuan Province fat, hundred, Rhizoma Paridis tetraphyllae, hundred medicine brocades, continuous Radix Astragali etc.
Main component: Radix Astragali contains sucrose, glucuronic acid, phlegmatic temperament, several aminoacid, bitter principle, choline, betanin, folic acid (the 65 micrograms/dried root of 100 grams), tells 2 ', 4 '-dihydroxy-5 again, 6-dimethoxy isoflavan and kumatakenin.
Feeble QI, it is little sweet to distinguish the flavor of, and that chews littlely has a beany flavor.
Have invigorating the spleen and replenishing QI, strengthening superficial resistance to stop perspiration, benefiting qi and raising yang, inducing diuresis to remove edema, the evacuation of pus of holder skin ulcer, treatment prostate hyperplasia, urine retention, surgery ulcer, leukopenia, chronic tracheitis, chronic diarrhea proctoptosis, uterine prolapse, weak sweating due to debility, body void is easy to catch cold, bad, the anemia of hematopoietic function, chronic nephritis, albuminuria, edema, hypertension, the deficiency of vital energy, chronic ulcer, open sore part disunion of a specified duration, apoplexy retreat that disease, metrorrhagia are lost blood, diabetes etc.
Cure mainly: control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and do not hold back for a long time.Invigorating the spleen and replenishing QI.Control the internal injury overstrain, diarrhea due to hypofunction of the spleen, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, and the card of all weakness of QI blood deficiency.
5, Radix Scutellariae:
Another name is: rotten intestinal, Huang Wen, rainbow win, through a kind of reed mentioned in ancient books, interior-deficiency, KONGXINCAO, Chimonanthus salicifolius S.Y.Hu. etc.
Main component: root contains baicalin 4.0%-5.0%, baicalin, wogonoside, wogonin, neobaicalein, 7-methoxyl group baicalin, 7-methoxyl group demethyl wogonin, oroxylin A, skullcapflavone, skullcapflavone.Skullcapflavone I 5,2-dihydroxy-7,8-dimethoxy flavone.Report still contains oroxylin A glucuronide, 5,7-dihydroxy-6,8,2 in addition, 3-tetramethoxy flavone, 5,8,2-trihydroxy-7-methoxy flavone, 5,8,2-trihydroxy-6,7-dimethoxy flavone, 5,7,4-trihydroxy-6-methoxy flavone, dihydro oroxylin A and chrysin.
Feeble QI, bitter in the mouth.
Have clearing away heat-fire, heat clearing and damp drying, clearing heat and preventing abortion, clearing away heat to stop bleeding.
Cure mainly: control the high fever excessive thirst, the cough due to lung-heat, damp-heat dysentery, yellow pox, pyretic stranguria is told, is defeated in battle, is collapsed.Leak conjunctival congestion and swelling pain, frequent fetal movement, carbuncle furuncle.
6, catechu:
Another name is: (Dai Nationality's language name) thanked in CATECHU, gambier, Catechu, black father's mud, the folded mud of crow, Wu Dingni, west.
This product beginning is stated from principle of Correct Diet, says it " go expectorant heat, go up yearningly, diuresis, removing stagnancy of indigested food and making QI downward, clear god sleeps less." Compendium of Material Medica is called black father's mud, Catechu, the folded mud of crow.Li Shizhen (1518-1593 A.D.) is said: " black father or make black fourth, all kind language does not have and corrects a wrongly written character or a misspelt word, and goes out kind Java, south, Siam Laos, it is made in ground such as modern Yunnan "." Bencao Jingshu " cloud: black father's mud, moderns use external treatment more, and are for oral administration very few.
7, SHANZHIZI
Another name is: Mu Dan, bright, ancient wine vessel, stand, little ancient wine vessel, yellow Ovum Gallus domesticus, yellow sprout, Fructus Gardeniae etc.
Main component: contain flavonoid gardenin, pectin, tannin, crocin, crocetin, D-mannitol, nonacosane, cupreol.Other contains the glycoside of the smelly formaldehyde structure of multiple tool ring.
Feeble QI, distinguish the flavor of little acid and hardship.
Have clearing heat and relieving fidgetness, eliminating damp-heat, cooling blood for hemostasis.
Cure mainly: control the calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea is quenched one's thirst, conjunctival congestion, pharyngalgia is spitted blood, epistaxis, dysentery, hematuria, pathopyretic ulcer is sprained and is swollen and ache.
8, Radix Sophorae Flavescentis:
Another name is: bitter bone, river ginseng, phoenix claw, cattle ginseng, hardship, water Chinese scholartree etc.
Main component: root contains multiple alkaloid (1%-2.5%), based on d-matrine and d-oxymatrine.Other contains micro-d-sophoranole, 1-anagyrine, 1-methylcytisine, 1-Baptisia leaf alkali, 1-sophocarpine, N-N-oxysophocarpine, the bright alkali of 1-ethyl Chinese scholartree, sophoridine, tetrandrine etc.Flavone compound has Radix Sophorae Flavescentis, different kurarinone, nor-kurarinone, inferior kurarinone, Radix Sophorae Flavescentis alcohol element, inferior Radix Sophorae Flavescentis alcohol element, plain, the nor-Radix Sophorae Flavescentis alcohol of neokurarinol element, nor-dehydration Herba Epimedii element, different dehydration Herba Epimedii element, lupulin, different lupulin and Russian red clover Koryo Chinese scholartree glycoside etc.
Feeble QI, flavor are extremely bitter.
Have heat clearing and damp drying, removing dampness to relieve itching, clearing away heat and promoting diuresis.
Cure mainly: control toxic-heat and blood stasis, discharging fresh blood stool, jaundice, leucorrhea with red and white discharge, infantile pneumonia, infantile malnutrition, acute tonsillitis, anal fistula, proctoptosis, skin pruritus, the mange malignant boil, erosion of vulva pruritus due to damp pathogen, scrofula is scalded.
9, Fructus Evodiae:
Another name is: Fructus Evodiae, left power, spicy, gas spicy, bent medicine, tea are peppery etc.
Main component: it is evodene, ocimene, obaculactone, evodol etc. that fruit contains volatile oil.Also contain xanthoxylic acid.Contain alkaloid again: rutaecarpin, rutaecarpine, wuchuyine, Hydroxyevodiamine, evocarpine.Also contain two kinds of nonnitrogenous materials of neutrality: evodinone and evogin.Contain evodine again.Stone tiger fruit contains obaculactone, rutaecarpin, rutaecarpine, Hydroxyevodiamine.Still contain undersaturated ketone, claim stone tiger beetle element, volatile oil, anthocyanin and steroidal compounds temporarily.Underdone fruit contains rutaecarpin, Demethyl Evodiamin, Fructus Evodiae quinoline ketone alkali, Hydroxyevodiamine, dehydroevodiamine and another kind of alkaloid evoxine and still contains evodol, limonin.Seed fatty acids 25 wherein has cis-5,8-14 carbon two diluted acids.
Gas fragrance is strong, and acrid in the mouth is peppery and bitter.
Cure mainly: the contrary acid regurgitation of stopping vomiting, headache due to JUE YIN disorder, the coldness of ZANG-organ is vomited and diarrhoea, abdominal distention, beriberi, hernia, aphthous ulcer, impetigo etc.Has the soothing the liver therapeutic method to keep the adverse QI flowing downwards, warming spleen and stomach for dispelling cold.
10, Radix Et Rhizoma Rhei:
Another name is: Radix Et Rhizoma Rhei, yellow good, fire ginseng, skin are high etc. as, general, bright and beautiful stricture of vagina, Radix Et Rhizoma Rhei.
Main component: chrysophanol one 1 one glycosides or chrysophan; Emodin one 6 one glycosides; Aloe-emodin one 8 one glycosides; Chrysophanic acid one 8 one glycosides; The physcione glycoside.Radix Et Rhizoma Rhei contains rheotannic acid and related substances thereof again, as gallic acid, and cachou extract and tetrarin.A gallic acid part is free, and a part and glucose are combined into galloyl glucose.Gallic acid, cinnamic acid and rheosmin are given birth in the tetrarin hydrolysis.These tannic acids and related substances thereof have anti-diarrhea effect, and be just opposite with the discharge function of the glycoside of anthraquinone derivative.
Be purple fluorescence under feeble QI, the bitter and puckery flavor, ultra-violet lamp.
Function cures mainly: control the excess-heat constipation, delirium is gone mad, the food stagnation feeling of fullness, dysentery is from the beginning of, tenesmus, stasis of blood menolipsis is closed, lump in the abdomen, the time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia is spitted blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, it is red to urinate, carbuncle and ulcer toxic swelling, furuncle, burn.
11, Radix Arnebiae (Radix Lithospermi):
Another name is: Asia puecon grass, Zi Dan, blood, Lacca, crow rank grass, Radix Arnebiae (Radix Lithospermi), mountain Radix Arnebiae (Radix Lithospermi), red Shi Gen etc.
Main component: Radix Arnebiae (Radix Lithospermi) contains Acetyl-shikonin Acetylshikonin, shikonin, alkannan, isobutyryl shikonin, β, beta-dimethyl-acryloyl shikonin, β-hydroxyl isovaleryl shikonin, 3,4-dimethyl pentene-3-acyl group shikonin.The false Radix Arnebiae (Radix Lithospermi) in Xinjiang-Tibet contains β-Qiang Jiyiwuxianzicaokun, 3,4-dimethyl pentene-3-acyl group shikonin.
Cure mainly: control warm macule, jaundice due to damp-heat, purpura tells, nosebleed, hematuria, stranguria with turbid discharge, dysentery, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Have clearing away heat and cooling blood, laxation relieving constipation.
12, Radix Sanguisorbae:
Another name is: it is red etc. that white Radix Sanguisorbae, Mus tail Radix Sanguisorbae, puckery Radix Sanguisorbae, horse connect saddle potato, mountain Fructus Jujubae root, Geranium strictipes R. Kunth, Radix Geranii Strictipedis, Fructus Jujubae.
Main component: it is about 17% that root contains tannin, triterpenoid saponin 2.5～4.0%, and root contains zigu-glucoside, and leaf and stem also contain Quercetin, kaempferol, flower and contain multiple anthocyanin.Call Radix Sanguisorbae acid dilactone and sanguiin H-1 again, H-2, H-3, H-6.
Odorless, mildly bitter flavor is puckery.
Function cures mainly: control haematemesis, epistaxis, dysentery, metrorrhagia, hemorrhoidal hamorrhage, anal fistula, carbuncle, eczema, incised wound, burn.Have cooling blood for hemostasis, skin ulcer is held back in detoxifcation: external can harness the river burning hot wound, eczema, eczema, skin ulceration etc.
13, Radix Ampelopsis:
Another name is: Bletilla striata (Thunb.ex A.Murray)Rchb.f., the Kunlun, cat ovum, goose hatch, JIANZHONGXIAO, wear mountain mouse, white water tank, mountain region melon, ferrum mouse etc.
Main component: mucous matter of root piece and starch.The powder that separate out on the congener surface is produced in Fujian, is Ampelopstin (3,5,7,3 ', 4 ', 5 '-hexahydroxy flavanone).This thing adds soda boiling and boils, then dehydrogenation and give birth to myricetin.Also contain tannin, flavonoid glycoside, glucose etc.
It is little sweet to distinguish the flavor of.
Cure mainly: control carbuncle, furuncle, scrofula is scalded pyrexial malaria, infantile convulsion, dysentery, hemorrhoidal hamorrhage, anal fistula.Heat-clearing and toxic substances removing is treated skin ulcer: cure mainly sore and toxic, from the beginning of disappearing, can hold back after bursting, Orally taken and externally all can.The also available burning hot wound of harnessing the river.
14, Galla Chinensis:
Another name is: Conch Meretricis seu Cyclinae, hundred worm storehouses, wooden Radix Aconiti Lateralis Preparata etc.
Main component: the Fructus rhois chinensis insect gall contains a large amount of gallotannic acids and resin, fat, starch.Contain Gallotannin, gallic acid, fat, resin and waxiness etc.
Character: be irregular cryptomere or Pedicellus et Pericarpium Trapae shape, some strumaes or horn shape branch are arranged, surperficial yellowish-brown has the fine hair of the soft cunning of canescence to taupe brown, and the matter heavily fortified point is crisp, hollow, conscience body and white crust and the powdery Excreta of the visible pitchy times aphid in broken back.With skin depth, greyish brown, the complete not broken person of color is good.
Cure mainly: control chronic cough of deficiency lung, chronic dysentery, chronic diarrhea, proctoptosis, spontaneous perspiration, night sweat, epistaxis, metrorrhagia, traumatic hemorrhage, toxic swelling, furuncle are had blood in stool in seminal emission.Have the pathogenic fire reducing of astringing the lung, relieving diarrhea with astringents, reinforcing the kindey to control nocturnal emission, arresting sweating, hemostasis etc.
15, Olibanum:
Another name is: smoked Lu Xiang, horse hair perfume (or spice), nipple perfume (or spice), the perfume (or spice) that collapses, the west is fragrant, it pool is fragrant, Moller is fragrant, bathe perfume (or spice) etc.
Main component: resinous 60～70%, natural gum 27～35%, volatile oil 3～8%.The main component of resin is free a, B one boswellic acid 33%, in conjunction with boswellic acid 1.5%, and olibanoresene 33%.Natural gum is the calcium salt and the magnesium salt 20% of arabitic acid, bassorin 6%; In addition, still contain amaroid 0.5%.It is faint yellow that volatile oil is, and fragrance is arranged, and contains pinene, racemization one limonene and a, B one phellandrene, and its main fragrance ingredient is not bright.And a derivant and a sylvan, neutral fraction contain α-, the derivant such as the α-amyrenone of β-amyrin still contain viridiflorol, Olibanum terpenes and oxidation Olibanum terpenes.
Feeble QI fragrance, mildly bitter flavor.
Cure mainly: control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Have promoting blood circulation and stopping pain, detumescence and promoting granulation: can be used for skin infection from the beginning of, red and swollen heat pain; Or the skin infection diabrosis, do not close up for a long time; And scrofula, the hard person that do not disappear of sucutaneous nodule.
16, Myrrha:
Another name: myrrh, bright Myrrha etc.
Main component: myrrh is resinous 25～35%, volatile oil 2.5～9%, and natural gum is about 57～65%, is moisture and various impurity about 3～4% in addition.Still contain heeraboresene, commiferin.Volatile oil is resinophore in air, contains eugenol, a phenyl methylcarbamate, cumaldehyde, pinene, cinene, limonene, cinnamic aldehyde, heerabolene etc.The natural gum hydrolysis gets arabinose, galactose and xylose.
Gas is fragrant beautiful special, and flavor is extremely bitter.
Function cures mainly: control traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Blood circulation promoting and blood stasis dispelling, the reducing swelling and alleviating pain effect is similar to Olibanum.Be used for diseases such as the carbuncle skin ulcer swells and ache, traumatic injury stasis of blood pain, amenorrhea more, also can be used for the vexed pain in ambition of qi depression to blood stasis.
17, Fructus Schisandrae Chinensis:
Another name: profound and, can and, five Fructus Armeniacae Mumes etc.
Main component: it is about 3% that fruit contains volatile oil, and the sesquialter that volume wherein arranged is alkene, β 2-bisabolence, β-chamigrene and ylangene etc. all.Contain citric acid 12% in the dry fruit, malic acid 10%, and a small amount of tartaric acid.Still contain monosaccharide, resin etc.
The sarcocarp sour in the mouth; Seed little Cheng Erxin that distinguishes the flavor of.
Cure mainly: control chronic cough of deficiency lung, lung is suffered from a deficiency of the kidney and is coughed, spontaneous perspiration, and night sweat is quenched one's thirst, nocturnal emission, spermatorrhea, incessant chronic diarrhea, cardiopalmus, insomnia.Have the nourishing kidney of astringing the lung, arresting seminal emission antidiarrheal: deficiency of kidney-QI, spleen-kidney vacuity cold, promote the production of body fluid mind tranquilizing and the heart calming: heat impairing vital QI the moon, the sweating body is tired, restlessness and thirst, heart deficiency of the kidney yin, the heart is become homeless foster, restlessness of asrhenia type and insomnia, cardiopalmus dreaminess, arresting sweating, also available controlling quenched one's thirst.
18, Borneolum Syntheticum:
Another name is: Borneolum Syntheticum, brain, auspicious Borneolum Syntheticum, Flos Mume brain, Borneolum Syntheticum brain, borneol Mei Bing etc.
Main component: this product is the crystallization that obtains from the resin of Borneolum Syntheticum and volatile oil, is to be close to pure dextro Borneolum Syntheticum.Contain multiple ter penoids in the resin of Borneolum Syntheticum and the volatile oil.Except that Borneolum Syntheticum, still contain sesquiterpenes such as oxalene, beta-elemene, caryophyllene, triterpenoids such as oleanolic acid, alphitolic acid, asiatic acid, dipterocarpol, dryobalanone, erythrodiol.
Character: for translucent seemingly Flos Mume lobe bulk, flaky crystalline solid, so claim " borneol "; Diameter 0.1-0.7cm, thick about 0.1cm; Off-white color is light taupe brown extremely, gas delicate fragrance, and it is refrigerant to distinguish the flavor of, and that chews slowly dissolves.Do not have black smoke during burning or little black smoke arranged.
Cure mainly: control the apoplexy locked mouth, calentura coma, frightened expectorant fan, deafness with qi stagnation, sore throat, aphtha, otitis media, carbuncle, hemorrhoid, conjunctivitis, enterobiasis.Have the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain, pull out dried removing dampness, arresting hemostasia and suppuration.
The present invention makes full use of the effect that aforementioned pharmaceutical compositions supplements and complements each other according to Chinese medical theory, reaches the effect of clearing away heat-fire, clearing away heat to stop bleeding, reducing swelling and alleviating pain, sterilizing and itch-relieving jointly, injury from falling down, scald is had the effect of activating blood circulation to dissipate blood stasis, back no cicatrix; Dermatosiss such as malignant boil tinea disease, skin sore, eczema, skin pruritus, mange malignant boil, erosion of vulva pruritus due to damp pathogen there are anti-inflammation, removing the necrotic tissue and promoting granulation, the effect of arresting hemostasia and suppuration.
Compared with the prior art, the present invention not only preparation technology is simple, and the cicatrix disappearance is fast, does not rebound, and pure Chinese medicinal preparation has no side effect.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
In order to test the direct influence of Chinese medicine liniment spray of the present invention to skin, the present invention has carried out
1. the acute toxicity test of skin:
10 of the mouse of selection 200～250mg are divided into two batch total amount groups and experimentize: the A group is subtotal amount group, and wound is a cross, directly liniment spray of the present invention is acted on the wound, and spray in a day is wiped once; B group is big metering group, and wound is two crosss, directly with liniment spray wiping of the present invention on wound, secondary is wiped in spray in a day; After one week, none death of two groups mouse, the wound epidermis of A group mouse has been tied snap, comes off; And the wound epidermis knot of B group mouse is all taken off, and epidermis does not have any cicatrix, and the mental status is good, does not have any abnormal conditions and occurs.
2. the test result of Chinese medicine liniment spray of the present invention in clinical trial:
Select medical history, the state of an illness, age, 900 exceptions that sex is suitable to hinder the patient and be divided into two groups of tests that compare, comprising wound, burn, scald, eczema ulcer, dermatocandidiasis are arranged.Group on probation adopts the Chinese medicine liniment spray of the present invention of external on probation to the patient, and every day 2 times, 14 days is a course of treatment; And " SHAOSHANG PENWUJI " medicine and 1% " Terbinafine Cream " and " SANHUANG GAO " that contrast groups adopts Hainan to produce, 2 times on the one, external, 14 days is one-period.The results are shown in Table 1.
Table 1 group on probation compares with the contrast groups curative effect
| Group name | Produce effects | Effectively | Invalid | Total effective rate |
| Group on probation | 138 examples | 357 examples | 5 examples | 99％ |
| 86％ | 58％ | 10％ |
| Contrast groups | 112 examples | 265 examples | 23 examples | 94％ |
| 76％ | 64％ | 17％ |
Result of the test: the total effective rate of Chinese medicine liniment spray of the present invention reaches 99%, obviously is better than contrast groups.
The contrast test of the property of medicine that 3. sterilizes:
Getting gram negative bacteria, gram positive bacteria and fungus is object of study, 's 20%, 40%, 80%, 100% variable concentrations with the liniment spray of the present invention of test group with the normal saline dilution, compare test with oxytetracycline, streptomycin, the chloromycetin of matched group, it is the bacterium sample that gram negative bacteria, gram positive bacteria and fungus are selected escherichia coli, staphylococcus aureus and Aspergillus niger respectively for use, and the result is as follows:
| Strain | Test group | Matched group | ||||||
| Oxytetracycline | Streptomycin | Chloromycetin | ||||||
| 10％ | 20％ | 40％ | 80％ | 100％ | ||||
| Escherichia coli | 4 | 12 | 22 | 28 | 29 | 28 | 22 | 29 |
| Staphylococcus aureus | 6 | 15 | 20 | 22 | 24 | 20 | 20 | 21 |
| Aspergillus niger | 3 | 12 | 15 | 18 | 18 | - | - | - |
The result shows:
Liniment spray of the present invention is diluted at 10% o'clock and has had the inhibitory action stronger to escherichia coli, staphylococcus aureus and Aspergillus niger, and along with the raising of variable concentrations, inhibitory action significantly is higher than matched group, has good antibacterial property.
Case 1
Liu Guofeng, man, 46 years old, welder.
In July, 2004, at ring bone place, left side wind weldering burn, area was at 6～8cm because of apprentice's operate miss, and the III degree is burnt.Hospitalize was not felt any better in 5 days, use " hundred disappear spirit " of the present invention liniment spray upon somebody's introduction after, any cicatrix is not stayed in recovery from illness in 8 days.
Case 2
Zhang Yan, woman, 42 years old
JIUYUE in 2003 is gone to a doctor evening on the 7th, and the fish oil splash is scalded to facial skin when cooking at home, by oneself: adopt ice cube to apply face, the damage of epidermis large tracts of land is come off.Behind " hundred disappear spirit " of the present invention from using liniment spray, recovery from illness in 12 days.
Case 3
Zhong Nan, man, 29 years old, Pekinese.Show effect repeatedly around mouthful throughout the year and suffer from impetigo, obstinate.
Use recovery from illness, recurrence so far in " hundred disappear spirit " of the present invention liniment spray 10 days from February 15th, 2003.
Case 4
Ma Hongzhi, man, 34 years old, driver.
In July, 2003 because of automobile before water tank water boil, and cause the scald of right half side body I degree, II degree and III degree in various degree." hundred disappear spirit " of the present invention from using liniment spray is wiped, is used antiinflammatory dead point medicine simultaneously by 4～6 sprays every day, and recovery from illness does not stay any cicatrix after 7 days.
Case 5
Dan Guofang, man, 74 years old, hemiplegia.
Because of bed throughout the year, respectively there is area at rumpbone place and rump place at 3～5cm, 2～6cm, and the decubital ulcer of 2cm is arranged deeply." hundred disappear spirit " of the present invention through using liniment spray was fully recovered after 10 days.
Case 6
Zhou Yan, woman, 38 years old
On July 8th, 2005 went to a doctor, and suffered from the pudendal ulcer disease for many years, obstinate.Behind " hundred disappear spirit " of the present invention from using liniment spray, after 8 days, recovery from illness.
Embodiment 1
Take by weighing Rhizoma Polygoni Cuspidati 100 gram, Rhizoma Coptidis 50 grams, Cortex Phellodendri 50 grams, the Radix Astragali 50 grams, Radix Scutellariae 50 grams, catechu 30 grams, SHANZHIZI 30 grams, Radix Sophorae Flavescentis 30 grams, Fructus Evodiae 30 grams, Radix Et Rhizoma Rhei's 30 grams, Radix Arnebiae (Radix Lithospermi) 30 grams, Radix Sanguisorbae 20 grams, Radix Ampelopsis 20 grams, Galla Chinensis 10 grams, Olibanum 10 grams, Myrrha 10 grams, Fructus Schisandrae Chinensis 10 grams, Borneolum Syntheticum 80 grams, select, rinsing, dry in the sun 1., earlier.
2., pulverize: the medical material after drying is pulverized, and except that Borneolum Syntheticum, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis is crossed 50 mesh sieve, and is in the container bag of packing into, standby; Then remaining 13 flavor medicine is crossed 30 mesh sieve, in another container bag of packing into, standby.
3. make liquid: Borneolum Syntheticum is dissolved in fills in 95% the alcoholic solution, according to 1: 500ml ratio obtain solution.
4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the ethanol that contains Borneolum Syntheticum mix in the hermetic container of liquid, placed 9 days, temperature remains in 25 degrees centigrade indoor.
Put into the mixed liquid hermetic container of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, placed 15 days again, temperature remains in 30 degrees centigrade indoor.
5. test: analyse detection bases, glycoside with reagent paper, observe solution colour then, as be dark brown, get final product filtering solution.
6. filter: will be the dark brown mixed solution and filter with 30 mesh sieves, and wait post precipitation reuse 50 mesh sieves to filter, the solution after the filtration is placed in the container of sealing lucifuge, can use.
Embodiment 2
1. take by weighing Rhizoma Polygoni Cuspidati 180 gram, Rhizoma Coptidis 120 grams, Cortex Phellodendri 120 grams, the Radix Astragali 100 grams, Radix Scutellariae 100 grams, catechu 80 grams, SHANZHIZI 50 grams, Radix Sophorae Flavescentis 50 grams, Fructus Evodiae 50 grams, Radix Et Rhizoma Rhei's 50 grams, Radix Arnebiae (Radix Lithospermi) 50 grams, Radix Sanguisorbae 40 grams, Radix Ampelopsis 40 grams, Galla Chinensis 30 grams, Olibanum 30 grams, Myrrha 30 grams, Fructus Schisandrae Chinensis 30 grams, Borneolum Syntheticum 150 grams earlier, select, rinsing, dry in the sun.
2. the medical material after drying is pulverized: except that Borneolum Syntheticum, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis are crossed 50 mesh sieve, and in the container bag of packing into, standby; Then remaining 13 flavor medicine is crossed 30 mesh sieve, in another container bag of packing into, standby.
3. make liquid: Borneolum Syntheticum is dissolved in fills in 95% the alcoholic solution, according to 1: 500ml ratio obtain solution.
4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the ethanol that contains Borneolum Syntheticum mix in the hermetic container of liquid, placed 8 days, temperature remains in 30 degrees centigrade indoor.Put into the mixed liquid hermetic container of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, placed 20 days again, temperature remains in 25 degrees centigrade indoor.
5. test: analyse detection bases, glycoside with reagent paper, observe solution colour then, as be dark brown, get final product filtering solution.
6. filter: will be the dark brown mixed solution and filter with 50 mesh sieves, and wait post precipitation reuse 70 mesh sieves to filter, the solution after the filtration is placed in the container of sealing lucifuge, can use.
Embodiment 3
1. take by weighing Rhizoma Polygoni Cuspidati 140 gram, Rhizoma Coptidis 110 grams, Cortex Phellodendri 110 grams, the Radix Astragali 75 grams, Radix Scutellariae 75 grams, catechu 55 grams, SHANZHIZI 40 grams, Radix Sophorae Flavescentis 40 grams, Fructus Evodiae 40 grams, Radix Et Rhizoma Rhei's 40 grams, Radix Arnebiae (Radix Lithospermi) 40 grams, Radix Sanguisorbae 30 grams, Radix Ampelopsis 30 grams, Galla Chinensis 20 grams, Olibanum 20 grams, Myrrha 20 grams, Fructus Schisandrae Chinensis 20 grams, Borneolum Syntheticum 115 grams earlier, select, rinsing, dry in the sun.
2. pulverize: the medical material after drying is pulverized, and except that Borneolum Syntheticum, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis is crossed 50 mesh sieve, and is in the container bag of packing into, standby; Then remaining 13 flavor medicine is crossed 30 mesh sieve, in another container bag of packing into, standby.
3. make liquid: Borneolum Syntheticum is dissolved in fills in 95% the alcoholic solution, according to 1: 500ml ratio obtain solution.
4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the ethanol that contains Borneolum Syntheticum mix in the hermetic container of liquid, placed 7 days, temperature remains in 25 degrees centigrade indoor.Put into the mixed liquid hermetic container of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, placed 14 days again, temperature remains in 20 degrees centigrade indoor.
5. test: analyse detection bases, glycoside with reagent paper, observe solution colour then, as be dark brown, get final product filtering solution.
6. filter: will be the dark brown mixed solution and filter with 40 mesh sieves, and wait post precipitation reuse 60 mesh sieves to filter, the solution after the filtration is placed in the container of sealing lucifuge, can use.
Embodiment 4
Take by weighing Rhizoma Polygoni Cuspidati 140 gram, Rhizoma Coptidis 110 grams, Cortex Phellodendri 110 grams, the Radix Astragali 75 grams, Radix Scutellariae 75 grams, catechu 55 grams, SHANZHIZI 40 grams, Radix Sophorae Flavescentis 40 grams, Fructus Evodiae 40 grams, Radix Et Rhizoma Rhei's 40 grams, Radix Arnebiae (Radix Lithospermi) 40 grams, Radix Sanguisorbae 30 grams, Radix Ampelopsis 30 grams, Galla Chinensis 20 grams, Olibanum 20 grams, Myrrha 20 grams, Fructus Schisandrae Chinensis 20 grams, Borneolum Syntheticum 115 grams, select, rinsing, dry in the sun 1., earlier.
2. the medical material after drying is pulverized: except that Borneolum Syntheticum, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis are crossed 50 mesh sieve, and in the container bag of packing into, standby; Then remaining 13 flavor medicine is crossed 30 mesh sieve, in another container bag of packing into, standby.
3. make liquid: Borneolum Syntheticum is dissolved in 60 degree sorghum wine according to 1: in the solution of 500ml ratio preparation.
4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the Chinese liquor that contains Borneolum Syntheticum mix in the liquid hermetic container, will place 10 days, temperature remains in 25 degrees centigrade indoor.Put into the mixed liquid hermetic container of the Chinese liquor of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, it is 40 degrees centigrade, 30 days by a definite date that the solution that fills medicine is placed on room temperature.
5. test: analyse detection bases, glycoside with reagent paper, observe solution colour then, as be dark brown, get final product filtering solution.
6. filter: will be the dark brown mixed solution and filter with 40 mesh sieves, and wait post precipitation reuse 60 mesh sieves to filter, the solution after the filtration is placed in the container of sealing lucifuge, can use.
Embodiment 5
1. take by weighing Rhizoma Polygoni Cuspidati 140 gram, Rhizoma Coptidis 110 grams, Cortex Phellodendri 110 grams, the Radix Astragali 75 grams, Radix Scutellariae 75 grams, catechu 55 grams, SHANZHIZI 40 grams, Radix Sophorae Flavescentis 40 grams, Fructus Evodiae 40 grams, Radix Et Rhizoma Rhei's 40 grams, Radix Arnebiae (Radix Lithospermi) 40 grams, Radix Sanguisorbae 30 grams, Radix Ampelopsis 30 grams, Galla Chinensis 20 grams, Olibanum 20 grams, Myrrha 20 grams, Fructus Schisandrae Chinensis 20 grams, Borneolum Syntheticum 115 grams earlier, select, rinsing, dry in the sun.
2. pulverize: the medical material after drying is pulverized, and except that Borneolum Syntheticum, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis is crossed 50 mesh sieve, and is in the container bag of packing into, standby; Then remaining 13 flavor medicine is crossed 30 mesh sieve, in another container bag of packing into, standby.
3. make liquid: Borneolum Syntheticum is dissolved in the 65 degree Chinese liquor of Shandong Fu Rui brewery production, according to 1: 500ml ratio preparation Chinese liquor mixes liquid.
4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the Chinese liquor that contains Borneolum Syntheticum mix in the liquid hermetic container, will place 15 days, temperature remains in 28 degrees centigrade indoor.
Put into the mixed liquid hermetic container of the Chinese liquor of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, it is 35 degrees centigrade, 40 days by a definite date that the solution that fills medicine is placed on room temperature.
5. test: analyse detection bases, glycoside with reagent paper, observe solution colour then, as be dark brown, get final product filtering solution.
6. filtration: will be the dark brown mixed solution and filter with 40 mesh sieves, post precipitation reuse 65 mesh sieves filters, and the solution after the filtration is placed in the container that seals lucifuge and can uses.
Claims (4)
- But 1, a kind of Chinese medicine liniment spray of quickly-healing wound, form by Rhizoma Polygoni Cuspidati, Rhizoma Coptidis, Cortex Phellodendri, the Radix Astragali, Radix Scutellariae, catechu, SHANZHIZI, Radix Sophorae Flavescentis, Fructus Evodiae, Radix Et Rhizoma Rhei, Radix Arnebiae (Radix Lithospermi), Radix Sanguisorbae, Radix Ampelopsis, Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum Chinese crude drug, according to listed as parts by weight, the drug component of this Chinese medicine liniment spray is:Rhizoma Polygoni Cuspidati 100～180, Rhizoma Coptidis 50～120, Cortex Phellodendri 50～120,The Radix Astragali 50～100, Radix Scutellariae 50～100, catechu 30～80,SHANZHIZI 30～50, Radix Sophorae Flavescentis 30～50, Fructus Evodiae 30～50,Radix Et Rhizoma Rhei 30～50, Radix Arnebiae (Radix Lithospermi) 30～50, Radix Sanguisorbae 20～40,Radix Ampelopsis 20～40, Galla Chinensis 10～30, Olibanum 10～30,Myrrha 10～30, Fructus Schisandrae Chinensis 10～30, Borneolum Syntheticum 80～150.
- But 2, the Chinese medicine liniment spray of a kind of quickly-healing wound according to claim 1 is characterized in that: optimum weight part proportioning of pharmaceutical composition is:Rhizoma Polygoni Cuspidati 140, Rhizoma Coptidis 110, Cortex Phellodendri 110, the Radix Astragali 75, Radix Scutellariae 75,Catechu 55, SHANZHIZI 40, Radix Sophorae Flavescentis 40, Fructus Evodiae 40, Radix Et Rhizoma Rhei 40,Radix Arnebiae (Radix Lithospermi) 40, Radix Sanguisorbae 30, Radix Ampelopsis 30, Galla Chinensis 20, Olibanum 20,Myrrha 20, Fructus Schisandrae Chinensis 20, Borneolum Syntheticum 115.
- 3, a kind of method for preparing pharmaceutical composition liniment spray of the present invention is:1. rinsing: with above-mentioned 18 flavor Chinese crude drugs select, rinsing, dry in the sun.2. pulverize: the medical material after drying, pulverize according to the weight portion back of weighing, earlier Galla Chinensis, Olibanum, Myrrha, Fructus Schisandrae Chinensis are crossed 50 mesh sieve, in the container bag of packing into, standby; Except that Borneolum Syntheticum, remaining 13 flavor Chinese crude drug is crossed 30 mesh sieve, in another container bag of packing into then, standby.3. make liquid: Borneolum Syntheticum is dissolved in fills in 95% the alcoholic solution, according to 1: 500ml ratio obtain solution.4. mix liquid: the Galla Chinensis, Olibanum, Myrrha, the Fructus Schisandrae Chinensis mixed bag that are equipped with are put into the ethanol that contains Borneolum Syntheticum mix in the hermetic container of liquid, placed 7～10 days, temperature remains in 25～35 degrees centigrade indoor.Put into the hermetic container of the mixed liquid of Galla Chinensis that above-mentioned preparation is housed, Olibanum, Myrrha, Fructus Schisandrae Chinensis, Borneolum Syntheticum with 13 flavor medicated bags are housed, placed 10～20 days again, temperature remains in 20～30 degrees centigrade indoor.5. test: detect bases, glycoside with the reagent paper chromatography; Observe solution colour then, be dark brown, get final product filtering solution.6. filter: will be the dark brown mixed solution and filter with 30～50 sieves, and wait post precipitation reuse 50～70 mesh sieves to filter, the solution after the filtration is placed in the container of sealing lucifuge, can use.
- 4, a kind of method for preparing pharmaceutical composition liniment spray of the present invention according to claim 3, it is characterized in that: the solution in the preparation of the present invention can substitute with the above Chinese liquor of 60 degree, operate according to the described pharmacy step of claim 3, it is 35～50 degrees centigrade, 20～40 days by a definite date that the solution that fills medicine is placed on room temperature, can finish whole process of preparation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100869563A CN1895471A (en) | 2006-06-20 | 2006-06-20 | Chinese-medicinal jet embrocation for healing wound and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006100869563A CN1895471A (en) | 2006-06-20 | 2006-06-20 | Chinese-medicinal jet embrocation for healing wound and its preparation |
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| CN110339389A (en) * | 2019-07-08 | 2019-10-18 | 生升美高科技(武汉)有限责任公司 | A kind of oiliness surface of a wound application and preparation method thereof |
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