CN110339389A - A kind of oiliness surface of a wound application and preparation method thereof - Google Patents
A kind of oiliness surface of a wound application and preparation method thereof Download PDFInfo
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- CN110339389A CN110339389A CN201910609536.6A CN201910609536A CN110339389A CN 110339389 A CN110339389 A CN 110339389A CN 201910609536 A CN201910609536 A CN 201910609536A CN 110339389 A CN110339389 A CN 110339389A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a kind of oiliness surface of a wound application, the raw material including following parts by weight: 40~80 parts of sesame oil, 5~30 parts of castor oil, 1~10 part of beeswax, 1~6 part of radix scutellariae, 1~6 part of the coptis, 1~6 part of Cortex Phellodendri, 1~6 part of Chinese gall, 1~6 part of olibanum, 1~6 part of cape jasmine, 0.5~5 part of radix ampelopsis and 0.5~3 part of borneol.Oiliness surface of a wound application provided by the invention is cooperated by several drugs according to specific proportion, and, hemostasis and pain-relieving clearing heat and detoxicating from the surface of a wound to expelling pus and promoting granulation is played a positive role in wound healing overall process, it can accelerate wound healing, and form is more stable, drug treating time is longer, and wound healing effect is more excellent；And oiliness surface of a wound application has preferable bioadhesion performance to skin, gas permeability pastes and not will lead to pain when taking off, and is conveniently replaceable, and cost is relatively low.The present invention also provides a kind of preparation methods of oiliness surface of a wound application.
Description
Technical field
The invention belongs to medical material technical fields, and in particular to a kind of oiliness surface of a wound application and preparation method thereof.
Background technique
Skin is the important barrier of human body, and all kinds of operations, wound, burn, dermatitis etc. will lead to skin disruption and defect,
Cause various wounds, wound repair is the key areas of medical development, for mitigating sufferer pain, early recovery and is kept away
Scar has great significance after being excused from a college course again.
Clinically usually dressing is added to carry out surface of a wound nursing using drug, but patient is often required to during medical treatment according to doctor
It advises and hospital or the replacement of clinic progress drug and dressing is periodically gone to also increase patient while medical staff's workload increases
Financial burden also patient is made to hurry back and forth back and forth；For increasing gerontal patient and remote districts underdeveloped, suffer from
Person's dressing is even more difficult.On the other hand, currently on the market 80% or more Wound dressing with traditional dressings such as gauze, cottons
Based on, and traditional dressing is usually easy and wound adhesion, peeling from adult often can all experience a burst of " pain of tearing
Chu ", if these dressing peeled from the skin of baby, it is likely that skin can be damaged, lead to apparent scar.Although mesh
Before further developed the functional innovation dressing of moist wounds nursing, but since its price is relatively high, it is difficult to universal to use.
It is a kind of with preferable bioadhesion performance, good permeability therefore, it is necessary to develop, it is conveniently replaceable and wound at low cost
Face application.
Summary of the invention
It is an object of the invention to overcome above-mentioned technical deficiency, a kind of oiliness surface of a wound application, oiliness surface of a wound application are proposed
Have preferable bioadhesion performance to skin, gas permeability pastes and not will lead to pain when taking off, and is conveniently replaceable, cost compared with
It is low；The purpose of another aspect of the present invention is to provide a kind of preparation method of oiliness surface of a wound application.
To reach above-mentioned technical purpose, technical solution of the present invention provides a kind of oiliness surface of a wound application, including following weight
The raw material of part: 40~80 parts of sesame oil, 5~30 parts of castor oil, 1~10 part of beeswax, 1~6 part of radix scutellariae, 1~6 part of the coptis, Cortex Phellodendri 1~
6 parts, 1~6 part of Chinese gall, 1~6 part of olibanum, 1~6 part of cape jasmine, 0.5~5 part of radix ampelopsis and 0.5~3 part of borneol.
Technical solution of the present invention additionally provides a kind of preparation method of oiliness surface of a wound application, includes the following steps:
S1, it stocks up by weight；
S2, radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine and radix ampelopsis are pulverized and sieved, obtains medicinal powder；By the medicinal powder
It is uniformly mixed with sesame oil, castor oil and beeswax, heats and medicine oil is made；
S3, the medicine oil temperature reduce after mixed with the borneol of crushing, mixed oil liquid is obtained, by the mixed oil liquid
Temperature is down to room temperature, filtering, then non-woven fabrics is impregnated in filtered mixed oil liquid, obtains finished product.
Compared with prior art, the beneficial effect comprise that
1, oiliness surface of a wound application provided by the invention passes through radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine, radix ampelopsis, ice
The Chinese medicines such as piece, and sesame oil, castor oil and beeswax is cooperated to be used cooperatively, using the synergistic effect between each raw material, the surface of a wound obtained is applied
Patch irritation is small, has no toxic side effect, and uses safe and effective, good penetrability；Wherein, radix scutellariae, the coptis, Cortex Phellodendri, cape jasmine, radix ampelopsis, ice
Piece is the drug of bitter cold, has effects that heat-clearing and damp-drying drug, hemostasis and pain-relieving；Chinese gall, nature and flavor are sour, puckery, cold, to various carbuncle swells sores
Furuncle plays hemostasis astriction；Olibanum nature and flavor are pungent, bitter, tepor, have effects that the promoting flow of qi and blood circulation, detumescence and promoting granulation；By the above Chinese medicine
On the one hand compatible use reinforces clearing heat and detoxicating effect, helps surface of a wound hemostasis and pain-relieving, on the other hand helps wound surface convergence myogenic,
Promote wound healing；Secondly, sesame oil itself is sweet, cool in addition to property, there is myogenic meat, the pain that relieves the pain, subduing inflammation, lower heat toxin, benefit skin to split
The effect of except, sesame oil and castor oil are finish, have non-drying, to wound without obvious irritation, ointment can be kept wet
And it is comfortable；The above several drugs are cooperated by specific proportion, hemostasis and pain-relieving clearing heat and detoxicating from the surface of a wound to expelling pus and promoting granulation, in the surface of a wound
Healing overall process is played a positive role, and can accelerate wound healing, and form is more stable, drug treating time is longer, wound healing
Effect is more excellent；
2, oiliness surface of a wound application provided by the invention is by that by being sufficiently mixed, can form sesame oil, castor oil and beeswax
Sufficiently stable matrix structure, it is ensured that dressing use can play sufficiently long-acting, stable effect；Non-woven fabrics is impregnated in mixing again
In oil liquid, the oiliness environment of oleaginous base can not only moisten the nutrition surface of a wound, promote the healing of surface of a wound physiological, reduce or do not stay scar
Trace；Can also air-isolation and bacterium, do not easily cause superinfection, and non-woven fabrics softness pro-skin, have airing function, be conducive to surface of a wound generation
It thanks to the discharge of object, while can also prevent wound and dressing adhesion, paste and not will lead to pain when taking off, be not easy to stay scar；
3, oiliness surface of a wound application provided by the invention is not required to disinfectant, does not stimulate the surface of a wound, without pain, letter easy to use
Single, general place oneself can easily exchange cards containing all personal details and become sworn brothers, and can solve remote countryside and the inconvenient pain spot to hospital dressing crowd；
4, oiliness surface of a wound application provided by the invention is suitable for simply and easily postoperative, small area either shallow wound or chronic routed
The dressing of the ulcer surface of a wound applies, and pastes within one day one, easy to use and low-cost.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention
It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to
Limit the present invention.
The embodiment provides a kind of oiliness surface of a wound application, the raw material including following parts by weight:
40~80 parts of sesame oil, 5~30 parts of castor oil, 1~10 part of beeswax, 1~6 part of radix scutellariae, 1~6 part of the coptis, Cortex Phellodendri 1~6
Part, 1~6 part of Chinese gall, 1~6 part of olibanum, 1~6 part of cape jasmine, 0.5~5 part of radix ampelopsis, 0.5~3 part of borneol.
The pharmacological effect of each raw material is as follows:
Radix scutellariae: bitter cold in nature enters the heart, lung, gallbladder, large intestine channel；With heat-clearing and damp-drying drug, excess fire is rushed down, the effect of hemostasis and pain-relieving.
The coptis: bitter cold in nature, return heart, spleen, stomach, gallbladder, large intestine channel；With heat-clearing and damp-drying drug, the effect of purging fire for removing toxin.
Cortex Phellodendri: bitter cold in nature returns kidney, bladder meridian；With heat-clearing and damp-drying drug, the effect of purging intense heat, except steaming, detoxification sore treatment.
Chinese gall: cold in nature sour, puckery, return lung, large intestine, kidney channel；With astringing lung-QI fall fire, astringing to arrest bleeding, the function of hygroscopic sore
Various carbuncle swells boils are played hemostasis astriction by effect.
Olibanum: nature and flavor are pungent, bitter, tepor, return heart, liver, the spleen channel；Have effects that the promoting flow of qi and blood circulation, detumescence and promoting granulation；Its bitter is logical
Leak into blood, can removing blood stasis and acesodyne, and the carbuncle that disappears that can invigorate blood circulation, putrefaction-removing granulation-promoting；Both enter blood system, and enter gas point, the stagnation of the circulation of vital energy in energy promoting circulation of blood, stagnation resolvation
Analgesic；Interior to declare logical internal organs qi and blood, external enwergy reaches channels and collaterals thoroughly, can be used for the pain card of all qi depressions to blood stasis.
Cape jasmine: bitter cold in nature, return heart, lung, tri-jiao channel；There is the effect of heat-clearing and damp-drying drug, purging intense heat, cool blood and hemostasis and pain-relieving.
Radix ampelopsis: bitter in taste, pungent, slightly cold, return heart, stomach meridian；With clearing heat and detoxicating, carbuncle that disappears dissipating bind, expelling pus and promoting granulation, swelling and pain relieving
The benefits of；It can the burning hot poison of removing summer-heat be evil and the function of expelling pus and promoting granulation analgesic, it may have clearing heat and cooling blood, astringing to arrest bleeding act on.
Borneol: nature and flavor are pungent, bitter, slightly cold, return heart, spleen, lung channel；The effect of heat-clearing and damp-drying drug, hemostasis and pain-relieving.
In some preferred embodiments of the invention, oiliness surface of a wound application, the raw material including following parts by weight: sesame oil
58~70 parts, 9~14 parts of castor oil, 6.8~7 parts of beeswax, 2~3.5 parts of radix scutellariae, 2~3.5 parts of the coptis, 2~3.5 parts of Cortex Phellodendri, five
2~2.5 parts of gall nut, 2~2.5 parts of olibanum, 2~2.5 parts of cape jasmine, 1~1.5 part of radix ampelopsis, 1.2~1.5 parts of borneol.
It is highly preferred that the oiliness surface of a wound applies, the raw material including following parts by weight: 70 parts of sesame oil, 9 parts of castor oil, beeswax
6.8 parts, 2 parts of radix scutellariae, 2 parts of the coptis, 2 parts of Cortex Phellodendri, 2 parts of Chinese gall, 2 parts of olibanum, 2 parts of cape jasmine, 1 part of radix ampelopsis and 1.2 parts of borneol.
The embodiments of the present invention also provide a kind of preparation methods of oiliness surface of a wound application, include the following steps:
(1) it stocks up by weight；
(2) radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine and radix ampelopsis are pulverized and sieved, obtains medicinal powder；By medicinal powder and fiber crops
Oil, castor oil and beeswax are uniformly mixed, and heat and medicine oil is made；
(3) it is mixed after the temperature of medicine oil reduces with the borneol of crushing, obtains mixed oil liquid, the temperature of mixed oil liquid is down to
Room temperature, filtering, then non-woven fabrics is impregnated in filtered mixed oil liquid, obtain finished product.
In some preferred embodiments of the invention, in step (2), when preparing medicinal powder, Chinese medicine material crosses 80 after crushing
Mesh.
In some preferred embodiments of the invention, in step (2), heating temperature is 110~130 when preparing medicine oil
DEG C, heating time is 1.5~2.5h.
In some preferred embodiments of the invention, the temperature of medicine oil is down to 90~100 DEG C by step (3).
In some preferred embodiments of the invention, borneol smashes it through 120 meshes in step (3).
Non-woven fabrics is impregnated in mixed oil liquid by step in (3), is not spy in dipping temperature and the dip time present invention
Other restriction, as long as can guarantee that mixed oil liquid can be sufficiently impregnated non-woven fabrics, those skilled in the art can be according to reality
Situation adjusts dipping temperature and dip time.
Below in conjunction with specific embodiment, the present invention will be described in further detail.It should be appreciated that tool described herein
Body embodiment is only used to explain the present invention, is not intended to limit the present invention.
Experimental method in the present invention is unless otherwise specified conventional method.
Experimental material used in the present invention is that market is commercially available unless otherwise specified.
Embodiment 1:
The embodiment of the present invention 1 provides a kind of oiliness surface of a wound application, the raw material including following parts by weight: 70 parts of sesame oil,
9 parts of castor oil, 6.8 parts of beeswax, 2 parts of radix scutellariae, 2 parts of the coptis, 2 parts of Cortex Phellodendri, 2 parts of Chinese gall, 2 parts of olibanum, 2 parts of cape jasmine, 1 part of radix ampelopsis
With 1.2 parts of borneol.
Oiliness surface of a wound application is prepared with the following method:
(1) radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine, radix ampelopsis are crushed, crosses 80 meshes, obtains medicinal powder；
(2) medicinal powder is added in the mixed liquor of sesame oil, castor oil and beeswax, is heated to 120 DEG C, stirred 2 hours, medicine is made
Oil；
(3) borneol is crushed to 120 mesh, borneol is added when medicine oil temperature is down to 95 DEG C, is uniformly mixed, is mixed
Oil liquid is closed, the temperature of mixed oil liquid is down to room temperature, non-woven fabrics is impregnated in mixed oil liquid, until being sufficiently impregnated by the filtering of 300 mesh
Afterwards, by cutting and cooling down, finished product is obtained.
Embodiment 2:
The embodiment of the present invention 2 provides a kind of oiliness surface of a wound application, the raw material including following parts by weight: 58 parts of sesame oil,
14 parts of castor oil, 7 parts of beeswax, 3.5 parts of radix scutellariae, 3.5 parts of the coptis, 3.5 parts of Cortex Phellodendri, 2.5 parts of Chinese gall, 2.5 parts of olibanum, cape jasmine
2.5 parts, 1.5 parts of radix ampelopsis and 1.5 parts of borneol.
Oiliness surface of a wound application is prepared with the following method:
(1) radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine, radix ampelopsis are crushed, crosses 80 meshes, obtains medicinal powder；
(2) medicinal powder is added in the mixed liquor of sesame oil, castor oil and beeswax, is heated to 110 DEG C, stirred 2.5 hours, is made
Medicine oil；
(3) borneol is crushed to 120 mesh, borneol is added when medicine oil temperature is down to 90 DEG C, is uniformly mixed, is mixed
Oil liquid is closed, the temperature of mixed oil liquid is down to room temperature, non-woven fabrics is impregnated in mixed oil liquid, until being sufficiently impregnated by the filtering of 300 mesh
Afterwards, by cutting and cooling down, finished product is obtained.
Embodiment 3:
The embodiment of the present invention 3 provides a kind of oiliness surface of a wound application, the raw material including following parts by weight: 40 parts of sesame oil,
25 parts of castor oil, 8.5 parts of beeswax, 5 parts of radix scutellariae, 5 parts of the coptis, 5 parts of Cortex Phellodendri, 3.5 parts of Chinese gall, 3.5 parts of olibanum, 3.5 parts of cape jasmine,
0.5 part and 0.5 part of borneol of radix ampelopsis.
Oiliness surface of a wound application is prepared with the following method:
(1) radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine, radix ampelopsis are crushed, crosses 80 meshes, obtains medicinal powder；
(2) medicinal powder is added in the mixed liquor of sesame oil, castor oil and beeswax, is heated to 130 DEG C, stirred 1.5 hours, is made
Medicine oil；
(3) borneol is crushed to 120 mesh, borneol is added when medicine oil temperature is down to 100 DEG C, is uniformly mixed, obtains
The temperature of mixed oil liquid is down to room temperature by mixed oil liquid, and non-woven fabrics is impregnated in mixed oil liquid by the filtering of 300 mesh, until sufficiently leaching
After stain, by cutting and cooling down, finished product is obtained.
Embodiment 4:
The embodiment of the present invention 4 provides a kind of oiliness surface of a wound application, the raw material including following parts by weight: 75 parts of sesame oil,
5 parts of castor oil, 3 parts of beeswax, 1.5 parts of radix scutellariae, 1.5 parts of the coptis, 1.5 parts of Cortex Phellodendri, 1.5 parts of Chinese gall, 1.5 parts of olibanum, cape jasmine 1.5
Part, 5 parts of radix ampelopsis and 3 parts of borneol.
Oiliness surface of a wound application is prepared using method in the same manner as in Example 1.
Test example 1
(1) research object: 180 because of operation etc. small area caused by a variety of causes, either shallow wound surface patient.It will suffer from
Person is divided into observation I group, observation II at random, observes III, observation IV and control group, and every group each 36.Wherein observation I group male 17
Example, female 19, the age 28~77 years old, average age (40 ± 3.9) year；It is 20 male to observe II group, female 16, the age 27~75
Year, average age (41 ± 3.1) year；It is 18 male to observe III group, female 18, the age 25~73 years old, average age (39 ± 4.5)
Year；Observe IV group male 21, female 15, the age 26~70 years old, average age (38 ± 3.7) year；Control group male 22, female 14
Example, the age 25~72 years old, average age (39 ± 4.2) year.When five groups of Gender ages, the wound depth, wound size, treatment
Between, kinds of Diseases etc. compare that there was no significant difference, be comparable (P > 0.05).
(2) test method: control group treatment method: control group patient's route dressing change method is given；Hydrogen peroxide, life are used first
It manages salt water and Iodophor and cleans the surface of a wound, clean after the surface of a wound and cover wound with sterile gauze, the case where according to diffusate, replace drug.
Observation group's treatment method: observation I~IV group patient gives the treatment method of the application of the surface of a wound made of the present embodiment 1~4 respectively, first
The surface of a wound first is cleaned with hydrogen peroxide, physiological saline and Iodophor, dressing covering wound is made with Examples 1 to 4 respectively after cleaning the surface of a wound,
Once a day.
(3) efficacy assessment standard: including patient outcomes and patient satisfaction.The therapeutic effect of patient is analyzed, first
The area of the original surface of a wound of patient is measured, later, the area reduced within the same time to patient wound measures,
Area/original surface of a wound the area reduced by calculating patient wound, carries out the comparison of therapeutic effect.By patient outcomes point
For 4 grades, it is respectively: cures (wound heals completely, and local organization is repaired completely)；Effective (wound face has apparent diminution,
And area is reduced for the 50% of the wound gross area)；Effectively (wound face has the diminution of part, and reducing area is the wound gross area
25%~50%)；(25% or the wound face that the wound area of diminution is less than the gross area are deepened) in vain.Organize medical care people
Member carries out writing for patient satisfaction survey's table, by providing investigation table of satisfaction degree to patient, and analyzes and count patient satisfaction
Degree evidence.
(4) statistical method: statistical procedures are carried out using software to the data obtained and analysis of making comparisons, enumeration data are adopted
With chi-square criterion, P < 0.05 is statistically significant.
(5) result: 1. therapeutic effect: the therapeutic effect of five groups of patients after the treatment is compared, and observation I group always has
Efficiency is 95.45%, and the total effective rate of observation II group is 94.63%, and the total effective rate of observation III group is 91.76%, observes IV
The total effective rate of group is 92.18%, is above the 70.45% of control group, and observation I~IV group and control group difference have statistics
Meaning (P < 0.05).2. satisfaction: the dissatisfaction of observation I group is 0%, and the dissatisfaction of observation II group is 0%, observes III
The dissatisfaction of group is 2%, and the dissatisfaction of observation IV group is 1%, is far below the 31.81% of control group；Observe I~IV group
Be satisfied in the main and very satisfied be above control group.Five groups of patients are in dissatisfaction, degree of being satisfied in the main, very satisfied degree ratio
More there is significant difference, has statistical significance (P < 0.05).
Test example 2
(1) research object: chronic infection wound patient 170, inclusion criteria: age > 18 years old, ulcer area 4.3~
12.7cm2, blood glucose is normal；It is divided into five groups using random digits table, control group patient 34, male 18, female 16, the age is
20~67 years old, average (46.2 ± 11.3) year, ulcer area is 4.3~12.7cm2, average (7.8 ± 1.5) cm2；I group is observed to suffer from
Person 34, male 20, female 14, the age is 21~68 years old, average (46.3 ± 10.6) year, ulcer area is 4.4~
12.7cm2, average (7.7 ± 1.6) cm2；II group patient 34 is observed, male 17, female 17, the age is 21~65 years old, average
(45.8 ± 9.7.) year, ulcer area be 4.5~12.5cm2, average (7.6 ± 1.7) cm2；Observe III group patient 34, male 20
Example, female 14, the age is 22~69 years old, average (46.7 ± 10.2) year, ulcer area is 4.3~12.7cm2, average (7.8 ±
1.4)cm2；Observe IV group patient 34, male 19, female 15, the age be 20~66 years old, be averaged (46.1 ± 10.7) year, ulcer
Area is 4.5~12.6cm2, average (7.7 ± 1.5) cm2；Five groups of patient ages, gender, ulcer areas compare, and difference is without statistics
It learns meaning (P > 0.05), is comparable.
(2) method: when first visit, giving the effective debridement treatment of patient wound, the scab shell tissue of necrosis is removed, as far as possible cruelly
Expose the surface of a wound, measure the size of wound area, gives accurate pain scores and wound surface scoring, after effective debridement, make
Use normal saline flushing.Control group patient is nursed using common dressing.Embodiment 1 is respectively adopted in observation I~IV group patient
The application of the surface of a wound made of~4 is nursed.Carry out pain scores and wound surface scoring, record again when dressing 1 week, 2 weeks
Five groups of patient outcomes' (fully recover, is effective, progressive, invalid) and surface of a wound recovery situation (total dressing change frequency, wound healing time).
(3) efficacy assessment standard:
1. pain scores standard: being evaluated using visual analogue scales (VAS), i.e. a Line Chart is divided into 10 etc.
Grade, score is higher, indicates that pain intensity is bigger, it is that pain intensity is commented that when pain Assessment, which measures pain intensity numerical value with ruler,
Point.
2. wound surface standards of grading: full marks 16 divide, and score is higher, and the surface of a wound restores better.
3. the evaluation criteria of therapeutic effect: (1) fully recovering: wound healing.(2) effective: to there is granulation to bear, diffusate obviously subtracts
Few, the surface of a wound is obviously reduced.(3) progress: the state of an illness improves, and diffusate is reduced, and the surface of a wound has diminution.(4) invalid: the state of an illness without improvement,
Even deteriorate.
(4) statistical method: this data data uses software row statistical analysis, and measurement data is with (x ± s) table
Show, examined using t, as a percentage, using chi-square criterion, P < 0.05 is that difference is statistically significant to enumeration data.
(5) result:
1. pain scores compare: pain scores difference is unobvious when five groups of patient's first visits；But five groups changing dressing for patient 1 week, 2 weeks
When pain scores compare, observation I group pain intensity average value be 0.22 ± 0.13；Observing II group pain intensity average value is 0.25
±0.16；Observing III group pain intensity average value is 0.33 ± 0.18；Observe IV group pain intensity average value for 0.31 ±
0.15；Control group pain intensity average value is 2.32 ± 1.03；Observe I~IV group and statistically significant (the P < of control group difference
0.05).As time went on, pain scores reduce.Wherein, pain scores are low when observing I~IV group changing dressing for patient 1 week, 2 weeks
In control group (P < 0.05).
2. surface of a wound scoring is compared: wound surface diversity of values is not statistically significant (P > 0.05) when five groups of patient's first visits.But
Wound surface scoring is compared at five groups changing dressing for patient 1 week, 2 weeks, and observation I group wound surface grade average is 15.1 points；Observation
II group wound surface grade average is 14.5 points；Observing III group wound surface grade average is 12.3 points；Observe IV group wound
Mouth surface of a wound grade average is 12.8 points；Control group wound surface grade average is 10.7 points；Observe I~IV group and control group
Difference is statistically significant.As time went on, wound surface scoring increases.Wherein, observation I~IV group changing dressing for patient 1 week, 2
Wound surface scoring is above control group (P < 0.05) when all.
3. therapeutic effect compares: when five groups of patient outcomes' distributions are compared, difference is statistically significant.Observe I group
Total effective rate is 95.53%, and the total effective rate of observation II group is 93.87%, and the total effective rate of observation III group is 92.32%, is seen
The total effective rate for examining IV group is 93.13%, is above the 76.36% of control group, and observation I~IV group patient outcomes are better than pair
According to group (P < 0.05).
4. surface of a wound recovery situation compares: for five groups of total dressing change frequencies of patient compared with wound healing time, difference has statistics
Meaning (P < 0.05).Wherein, the observation total dressing change frequency of I~IV group patient is less than control group (P < 0.05).Observe I group patient
Wound healing average time is 11 days, and observation II group wounds healing average time is 11 days, and observation III group wounds are cured
Closing average time is 14 days, and observation IV group wounds healing average time is 13 days, earlier than 19 days (P < of control group
0.05)。
By test example 1~2 it is found that a kind of oiliness surface of a wound application provided by the present invention can accelerate being cured for chronic infection wound
Close, significant in efficacy and pain is lighter, to the dressing of postoperative, small area either shallow wound or chronic ulcer application aspect have than
More significant clinical value safely and effectively, facilitates economy, is worth clinical promotion and application.
The above described specific embodiments of the present invention are not intended to limit the scope of the present invention..Any basis
Any other various changes and modifications that technical concept of the invention is made should be included in the guarantor of the claims in the present invention
It protects in range.
Claims (8)
1. a kind of oiliness surface of a wound application, which is characterized in that the raw material including following parts by weight: 40~80 parts of sesame oil, castor oil 5~
30 parts, 1~10 part of beeswax, 1~6 part of radix scutellariae, 1~6 part of the coptis, 1~6 part of Cortex Phellodendri, 1~6 part of Chinese gall, 1~6 part of olibanum, Cape jasmine
1~6 part of son, 0.5~5 part of radix ampelopsis and 0.5~3 part of borneol.
2. oiliness surface of a wound application according to claim 1, which is characterized in that the oiliness surface of a wound application includes following weight
The raw material of part: 58~70 parts of sesame oil, 9~14 parts of castor oil, 6.8~7 parts of beeswax, 2~3.5 parts of radix scutellariae, 2~3.5 parts of the coptis, Huang
2~3.5 parts of cypress, 2~2.5 parts of Chinese gall, 2~2.5 parts of olibanum, 2~2.5 parts of cape jasmine, 1~1.5 part of radix ampelopsis and borneol 1.2~
1.5 part.
3. oiliness surface of a wound application according to claim 2, which is characterized in that the oiliness surface of a wound application, including weigh as follows
Measure the raw material of part: 70 parts of sesame oil, 9 parts of castor oil, 6.8 parts of beeswax, 2 parts of radix scutellariae, 2 parts of the coptis, 2 parts of Cortex Phellodendri, 2 parts of Chinese gall, cream
2 parts fragrant, 2 parts of cape jasmine, 1 part of radix ampelopsis and 1.2 parts of borneol.
4. a kind of preparation method of oiliness surface of a wound application as claimed in any one of claims 1 to 3, which is characterized in that including such as
Lower step:
S1, it stocks up by weight；
S2, radix scutellariae, the coptis, Cortex Phellodendri, Chinese gall, olibanum, cape jasmine and radix ampelopsis are pulverized and sieved, obtains medicinal powder；By the medicinal powder and fiber crops
Oil, castor oil and beeswax are uniformly mixed, and heat and medicine oil is made；
S3, the medicine oil temperature reduce after mixed with the borneol of crushing, mixed oil liquid is obtained, by the temperature of the mixed oil liquid
It is down to room temperature, filters, then non-woven fabrics is impregnated in filtered mixed oil liquid, obtains finished product.
5. the preparation method of oiliness surface of a wound application according to claim 4, which is characterized in that prepare institute in the step S2
When stating medicinal powder, Chinese medicine material crosses 80 meshes after crushing.
6. the preparation method of oiliness surface of a wound application according to claim 4, which is characterized in that prepare institute in the step S2
When stating medicine oil, heating temperature is 110~130 DEG C, and heating time is 1.5~2.5h.
7. the preparation method of oiliness surface of a wound application according to claim 4, which is characterized in that by medicine oil in the step S3
Temperature be down to 90~100 DEG C.
8. the preparation method of oiliness surface of a wound application according to claim 4, which is characterized in that by borneol in the step S3
Smash it through 120 meshes.
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