CN1883486A - Method for preparing compound double-layered tablet of carisoprodol-aspirin - Google Patents
Method for preparing compound double-layered tablet of carisoprodol-aspirin Download PDFInfo
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- CN1883486A CN1883486A CN 200510046724 CN200510046724A CN1883486A CN 1883486 A CN1883486 A CN 1883486A CN 200510046724 CN200510046724 CN 200510046724 CN 200510046724 A CN200510046724 A CN 200510046724A CN 1883486 A CN1883486 A CN 1883486A
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- aspirin
- enteric
- carisoprodol
- double
- liquid
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Abstract
The invention relates to the process for preparing double layer compound tablets of Carisoprodol and Aspilin as skeletal muscle relaxant, which comprises making Aspirin enteric granules, the carrying out pelletization to Carisoprodol through double layered pelleting machines.
Description
Invention field:
The present invention relates to contain carisoprodol and aspirin is the preparation method of the central skeletal muscle relaxant compound double-layer tablet of effective ingredient.
Background technology:
The skeletal muscle relaxant that compound double-layered tablet of carisoprodol-aspirin is American Pharmacopeia 26 editions, 27 editions determined curative effects that record, toxic and side effects is little is widely used in clinical in the U.S. and Europe.The chief editor of American Medical Association " clinical medicine " given higher rating to this medicine.
Because carisoprodol has certain alkalescence, aspirin has certain acidity, will make two compositions produce drug interaction by traditional handicraft mixing granulation tabletting, influences drug quality and stability.For this reason, United States Patent (USP) (US4,534,973) once disclosed makes the granule that discharges in the common stomach respectively with carisoprodol and aspirin, makes the method for double-layer tablet then through bi-layer tablet press.This method interacts to avoiding two medicines, ensures drug quality and has played positive role.But consider the double-layer tablet of the traditional method of granulating compacting of above-mentioned United States Patent (USP) system's employing, contact interface part between the two-layer medicine of double-layer tablet still has certain interaction, and the aspirin of this recipe quantity under one's belt stripping be conspicuous to stimulation and the damage that gastric mucosa brings, therefore part has the patient of bleeding tendency can not take this medicine clinically.Be the harmful effect of avoiding above-mentioned situation to bring, we have designed a kind of new carisoprodol and aspirin double-layer tablet preparation method.
Summary of the invention:
Carisoprodol of the present invention and the preparation of aspirin double-layer tablet are the aspirin granules of getting the conventional method preparation, adopt enteric material to carry out spray coating, and coating solution atomisation drop is covered particle surface, and the dry rapidly enteric coating layer that forms.Enteric solubility film coating agent weight only is the heavy 3.5-4.5% of particle cores, can keep aspirin granule prescription supplementary material dosage not change, so the sheet of double-layer tablet does not heavily have tangible increase.
The basic composition of the film coating prescription among the present invention is as follows:
II acrylic resin alcoholic solution (50g/L) 200ml, diethyl phthalate 2ml, Oleum Ricini 6ml, polyoxyethylene sorbitan monoleate 2ml, dimethicone 2ml, titanium dioxide (120 order) 6g, Pulvis Talci (120 order) 6g.
Enteric material among the present invention comprises pharmaceutically acceptable enteric film coating material of enteric solubility acrylic resin, hydroxypropylmethyl cellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), Lac and other.
The invention will be further described by the following examples.
Embodiment
(1) preparation of enteric thin film bag liquid
[prescription]
II acrylic resin alcoholic solution (50g/L) 200ml
Diethyl phthalate 2ml
Oleum Ricini 6ml
Polyoxyethylene sorbitan monoleate 2ml
Dimethicone 2ml
Titanium dioxide (120 order) 6g
Pulvis Talci (120 order) 6g
[method for making]
It is in 70% the ethanol that the II acrylic resin is added volume fraction, adds a cover to place after stirring a little and spends the night, and stirs and makes dissolving, is made into the concentration of 50g/L.Other get ethanol an amount of with prescription in after all the other compositions grind evenly, again with coating material solution mix homogeneously, promptly.
(2) preparation of carisoprodol-aspirin double-layer tablet
Get carisoprodol fine powder 200g, aspirin fine powder 350g, granulate according to a conventional method respectively, the aspirin granule that makes is sprayed with enteric thin film bag liquid, make fully to cover particle surface, the dry rapidly clothing layer that forms.Get carisoprodol granule and aspirin enteric-coated granule, use the bi-layer tablet press tabletting, make 1000 of compound double-layered tablet of carisoprodol-aspirin.
Claims (7)
1. preparation method that contains carisoprodol and aspirin oral administered compound double-layer tablet, it is characterized in that, the preparation of granules of the aspirin layer in this double-layer tablet, the plain particles spray of adopting aspirin is with enteric coating liquid, make the interface of two medicine layers that drug interaction not take place, ensure drug quality and medicine stability; Aspirin layer granule bag in this double-layer tablet is with enteric coating, avoided the stimulation and the bleeding tendency that discharge under one's belt after oral.
2. the preparation method described in the claim 1, the prescription of the medicine of double-layer tablet consists of carisoprodol and aspirin.
3. the preparation method described in the claim 1, the prescription of enteric film coating liquid consists of: a kind of film former, three kinds of solvents, a kind of solubilizing agent, two kinds of plasticizers.
4. the film former of the described enteric film coating of claim 3 liquid is pharmaceutically acceptable enteric film coating material of enteric solubility acrylic resin, hydroxypropylmethyl cellulose phthalate (HPMCP), cellulose acetate phthalate (CAP), Lac and other.Be preferably II acrylic resin alcoholic solution, its concentration is 10g/L～50g/L, and its consumption is 100ml～300ml.
5. the solvent of the described enteric film coating of claim 3 liquid is respectively diethyl phthalate, Oleum Ricini, dimethicone.Consumption is respectively diethyl phthalate 0.1ml～5ml, Oleum Ricini 1ml～10ml, dimethicone 0.5ml～5ml.
6. the solubilizing agent of the described enteric film coating of claim 3 liquid is a polyoxyethylene sorbitan monoleate, and its consumption is 0.5ml～5ml.
7. the plasticizer of the described enteric film coating of claim 3 liquid is respectively titanium dioxide (120 order), Pulvis Talci (120 order).Consumption is respectively titanium dioxide 1g～10g, Pulvis Talci 1g～10g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510046724 CN1883486A (en) | 2005-06-22 | 2005-06-22 | Method for preparing compound double-layered tablet of carisoprodol-aspirin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510046724 CN1883486A (en) | 2005-06-22 | 2005-06-22 | Method for preparing compound double-layered tablet of carisoprodol-aspirin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1883486A true CN1883486A (en) | 2006-12-27 |
Family
ID=37581869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510046724 Pending CN1883486A (en) | 2005-06-22 | 2005-06-22 | Method for preparing compound double-layered tablet of carisoprodol-aspirin |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1883486A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198147A (en) * | 2010-03-24 | 2011-09-28 | 济南瑞安药业发展有限公司 | New preparation method for aspirin-containing compound preparation |
| CN102885797A (en) * | 2012-10-29 | 2013-01-23 | 福州海王福药制药有限公司 | Composition containing pravastatin calcium as well as preparation method and application thereof |
-
2005
- 2005-06-22 CN CN 200510046724 patent/CN1883486A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102198147A (en) * | 2010-03-24 | 2011-09-28 | 济南瑞安药业发展有限公司 | New preparation method for aspirin-containing compound preparation |
| CN102885797A (en) * | 2012-10-29 | 2013-01-23 | 福州海王福药制药有限公司 | Composition containing pravastatin calcium as well as preparation method and application thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |