CN1879696A - Preparation for promoting secretion of saliva, its preparation method and application - Google Patents
Preparation for promoting secretion of saliva, its preparation method and application Download PDFInfo
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- CN1879696A CN1879696A CN 200610079648 CN200610079648A CN1879696A CN 1879696 A CN1879696 A CN 1879696A CN 200610079648 CN200610079648 CN 200610079648 CN 200610079648 A CN200610079648 A CN 200610079648A CN 1879696 A CN1879696 A CN 1879696A
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Abstract
Disclosed is a preparation for promoting the production of the body fluid, which is prepared from kudzu root and peppermint through conventional procedures, and can be made into medicine or health food that can be used for the treatment of halitosis and diabetes mellitus.
Description
Technical field
The present invention relates to a kind of promote the production of body fluid preparation and preparation method thereof and application that promotes salivation, belong to Chinese medicine or field of health care food.
Background technology
Saliva being is of value to health and life-prolonging important substance.Health preserving in ancient times scholar, the physician pays much attention to and give a lot of laudatory titles, reach 20 as gold paste, good wine, Jinin, Yuquan, manna, Shen Shui, Yu Chishui, Herba Herminii etc. surplus kind.The traditional Chinese medical science is looked the spleen being the foundation of acquired constitution, the kidney being the origin of congenital constitution, thinks that saliva is the spleen kidneyization, and saliva is relevant with vital movement.According to some doctor's nationalitys, document, newpapers and periodicals, magazine record, the function and the purposes of saliva mainly contain:
1, health care: the protein that the parotin in the saliva is made up of tens seed amino acids, content is atomic, acts on very greatly, helps to keep the normal activity of body, postpones organ senescence, strengthens immune function of human body.Saliva is again the ingredient of body fluid in the body, and body fluid is full could have good health and a long life.
2, bactericidal action: contain lysozyme in the saliva, can dissolve some antibacterial; Contain the change enzyme again, can make some pathogen become nonpathogenic bacteria, also can kill or suppress some alien bacteria such as Hemolytic streptococcus, escherichia coli, staphylococcus etc., can eliminate halitosis simultaneously.
3, facilitating digestion: saliva can promote the amylolysis in the food to become maltose and be converted into glucose, helps food digestion and absorbs.
4, lubricatedly help pharynx: saliva can make oral mucosa soft lubricated, is beneficial to chew, swallow, and also helps the function operation of language.
5, cushioning effect: saliva has stronger cushion effect, and inorganic constituents wherein has acid-base balance, ion exchange and the infiltrative effect regulated, and when in the oral cavity acid-base material being arranged, saliva can neutralize soon, makes it to keep neutral, faintly acid or alkalescence.
6, take care of one's teeth: some illness such as salivary gland inflammation, atrophy, hyperpyrexia, dehydration, diabetes etc. can cause that all salivation reduces, and cause the oral mucosa drying, and the oral cavity self-cleaning action weakens, and is easy to generate dental caries.Calcium phosphate in the saliva can make the tooth calcification, and can repair the small hole on the tooth, and the saliva of volume helps dental growth.Often swallowing saliva is particularly done from the child, can reduce or prevent the generation and the development of dental caries.
7, promote to grow: U.S. scientist found through experiments, a kind of special chemical substance---saliva somatomedin is arranged in the saliva, can promote the growth division of human body cell, quicken DNA (deoxyribonucleic acid) and proteinic synthetic in the cell, help the growth and the maturation of body.
8, detoxifcation anti-cancer: Japanese scientist finder's saliva has the toxic effect of the carcinogen of elimination, it is a kind of natural anticarcinogen, some carcinogen such as flavacin, benzopyrene, nitroso compound etc. are in vitro mixed with the saliva that the people spues and swing repeatedly about 30 seconds, the toxicity of invisible spectro carcinogen has 80%～100% to disappear.
9, anti-arthritis: Britain physician professor Huo Ji is by finding 29 routine rheumatic arthritis patients and 23 routine healthy person comparative studies, rheumatic arthritis patient's saliva is obviously reduced, thereby confirms that the saliva minimizing increases the weight of relevant with the rheumatic arthritis morbidity and the state of an illness.Professor Huo Ji points out that aptyalism can cause arthritis, should notice preventing that saliva from reducing or shortage.
Not only people's saliva has many functions like this, and the saliva of animal also has some effect: use tongue licking wounds energy accelerating wound healing in injured back as animal; The bald head that the saliva of cattle is licked (being coated with) people can impel hair growth promoting etc.
Because saliva has the human body many-side unique effects of health care anti-cancer particularly, therefore go through and praised highly by the Chinese and foreign department scholar.The argumentation of curing in the nationality relevant saliva health preserving at all times is a lot, and the Huangdi's Internal Classics before two thousand years is just pointed out to swallow saliva and can be got rid of illness and take care of health.The Northern and Southern Dynasties cure tame TAO Hong-Jing and say: " pharynx Yuquan person makes us prolonging life, and removes all kinds of diseases and ailments ".Here it is, and the descendant is referred to as important health care's method of " swallowing saliva health preserving ".
Write articles according to Zhourong's base: " saliva being go a long way health and valuable material should often be swallowed, and except nonvoluntary waste, losing, also should adopt various measures and ptyalize." (swallowing saliva health preserving, SiChuan publishing house, 1989,75.)
The health preserving scholar all proposes at all times, can be consciously stirs oral cavity methods such as (stirring the sea) by clicking the teeth or the tip of the tongue top palate or tongue and impels salivary glands secrete saliva, and gradation is swallowed slowly, the merit that has health preserving to prolong life.But these methods waste time and energy and produce little effect.In addition, but once had doctor family to recommend to suck Radix Ophiopogonis or chew gum saliva stimulating gland hypertrophy saliva, but repeatedly on probation through many people, its effect is very not obvious.Because about people to three ten years old, the parotid gland of secreting parotin in a large number begins atrophy, and after this with advancing age, salivary gland function is faded, and the physiological phenomenon of xerostomia appears in the corresponding minimizing of salivation amount, and motherland's medical science thinks that this is due to body fluid lacks.Therefore, that many people wish is can be safe in utilization nontoxic, can be effectively and promote rapidly the promote the production of body fluid medicine or the health food of salivation not increase the saliva product but occur this type of on the market so far.
Summary of the invention
The object of the present invention is to provide a kind of preparation that promotes the production of body fluid that promotes salivation.
Another object of the present invention is to provide the preparation method and the main production equipments thereof of this preparation that promotes the production of body fluid.
The present invention also aims to provide the application of this preparation that promotes the production of body fluid.
Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to xerostomia, ozostomia mechanism, achieve with reference to modern pharmacological research, from motherland's medicine treasure-house, filter out promote the production of body fluid, quench the thirst, sore-throat relieving, the homologous natural edible-plant medicine of medicated diet, by theory of Chinese medical science ancestral side, adopt modern sophisticated equipment, make medicine improve biological activity, promote salivation, eliminate xerostomia, halitosis symptom, and can reach the health-care effect of swallowing saliva health preserving.
Primary raw material of the present invention is the Chinese medicine Radix Puerariae, is the dry root of legume pueraria lobata or Radix Puerariae rattan, and other raw material comprises the Chinese medicine Herba Menthae, is the dry aerial parts of labiate Herba Menthae.
Radix Puerariae sweet in the mouth cool in nature is nontoxic, ends excessive thirst, rushes down stomach-fire, blood pressure lowering, and preventing thrombosis, the antidiarrheal blood sugar lowering, blood circulation promoting and blood stasis dispelling, the expansion cardiovascular and cerebrovascular vessel are improved blood circulation, but auxiliary treatment hypertension, coronary heart disease, diabetes etc.
Herba Menthae is cool in nature, ends excessive thirst, treats ability to speak, clearing throat, wind-dispelling heat-dissipating detoxifcation, anti-inflammatory analgetic, blood vessel dilating.Two medicines cooperate, and promoting the production of body fluid, quench the thirst, complementing each other aspect the moistening and cleaning throat, bring out the best in each other, and have synergistic function.
The specific embodiment:
The preparation that promotes the production of body fluid of the present invention comprises that following bulk drugs makes:
Radix Puerariae 30～200 Herba Menthaes 1～15
Formula optimization weight (part) ratio range for preparing the preparation that promotes the production of body fluid of the present invention is:
Radix Puerariae 70～150 Herba Menthaes 2～10
The optimum weight of the preparation that promotes the production of body fluid of the present invention (part) proportioning is:
Radix Puerariae 100 Herba Menthaes 5
Above-mentioned each component is made the promote the production of body fluid production method of preparation of the present invention to be comprised the following steps:
A, with Radix Puerariae remove impurity, clean silt, water logging runs through, and is cut into sheet or blockage, soaks about 1 hour, pulls out, drop goes to drip.With the common method finish-drying.
B, exsiccant Radix Puerariae sheet, piece are adopted disintegrating apparatus---comprise that universal mill, pulverizing mill are processed into powder, thin more good more, preferred fine powder level is above until cell wall breaking level micropowder or nanoscale micropowder, be beneficial to enlarge the contact area in medicine and oral cavity, promote the absorption of oral mucosa to medicine, thereby the raising bioavailability reduces taking dose, increases substantially and takes effect.
C, Radix Puerariae powder sieve is removed fiber and coarse powder.
D, dry Herba Menthae is followed an example to do (choose decontamination, remove undesirable root, cutting sieve dedust bits) are made as powder according to b, c method then, sieve.
E, Radix Puerariae, Herba Menthae powder that c, d are obtained take by weighing mix homogeneously by weight ratio, and be stand-by with the conventional method sterilization.
The Radix Puerariae that said method is obtained adopts common process adding acceptable accessories or makes acceptable clinically medicinal preparation for oral administration or health food with food with the powder that mixes of Herba Menthae, the dosage form of medicine or the kind of health food comprise tablet, powder, capsule, granule, oral liquid, syrup, beverage etc., can be used for promoting salivation and treatment or prevention xerostomia, ozostomia and adjuvant therapy of diabetes.
Because Radix Puerariae and Herba Menthae not only belong to medicine but also belong to food, are the homologous plants of medicated diet.Therefore, Radix Puerariae and the Herba Menthae mixed-powder that adopts said method to obtain can be used as the raw material of producing health food again.National correlation department has been ratified 27 kinds of health cares to health food, and " moistening and cleaning throat " function wherein is applicable to range of application of the present invention.Therefore, the health food or the functional food that can cooperate food or food production to have " cleaning throat and moistening larynx " effect in the above-mentioned preparation that promotes the production of body fluid.The visual different auxiliary material of adapted amount of mixed-powder and adjuvant or the kind of food, characteristics etc. are allotment arbitrarily.The dose of various dosage forms is in pure Radix Puerariae dry powder, and be 3～15g general every day, in case of necessity consumption a little.Consumption is basic identical when making health food.
Above-mentioned adjuvant comprises excipient or food, they contain water, alcohol, binding agent, filler, sweeting agent, flavoring agent, food additive etc., wherein comprise natural prodcuts or sintetics and varieties of food items such as starch, sugar, citric acid, Fructus Citri Limoniae alcohol, antiseptic, food glue, edible essence, food coloring.The consumption of adjuvant and/or food can be taken the circumstances into consideration adapted with custom with pharmaceutical dosage form or food variety and user's hobby.
Radix Puerariae is used as medicine, take with decoct or its extract clinically, the present invention then need not decoct or extract, as long as its raw medicinal herbs just can directly be prepared into promote the production of body fluid medicine or health food after soaking the drying and crushing sterilization, both amounts of ptyalizing fast, bring unforeseeable technique effect, helping by suitability for industrialized production again is Chinese patent medicine or health food, is easy to carry, takes and store.These preparation methoies of Radix Puerariae and give birth to method and increase the saliva effect and do not see literature record so far, this is the difference with traditional usage.In order to simplify processing link, also available its extract Oleum menthae of the Herba Menthae in the raw material substitutes.
Beneficial effect
Use the present invention and can obtain following beneficial effect:
1, promotes salivation.Edible Radix Puerariae promotes the production of body fluid behind the preparation, and the oral cavity is fast born fluid in one minute, and saliva such as gush are even often suffer from xerostomia person or middle-aged and elderly people also has effect like this.Simultaneously, every function of above-mentioned saliva also manifests thereupon gradually, has clear and definite, stable health-care effect.
2, can eliminate halitosis.The reason that causes halitosis is a lot, mainly is the gastric heat disease, causes the salivation amount to reduce, and is dry in mouthful, and antibacterial takes advantage of the occasion to breed in a large number.Owing to take kudzu vine root preparation and can produce a large amount of salivas rapidly and have sterilizing function, add that Radix Puerariae itself has strong heat clearing away and rushes down the stomach-fire effect, two kinds of effectiveness is worked along both lines, treating both the principal and the secondary aspects of a disease at the same time, and treatment or prevention gastric heat ozostomia are had curative effect preferably.
3, adjuvant therapy of diabetes.Radix Puerariae is one of conventional Chinese medicine of treatment diabetes.The classical symptom of diabetics is " three-many-one-little ", wherein more than two be polydipsia, polyuria.Because the normal sense of patient is thirsty, the daily drink amount has more several times than ordinary person, and polydipsia must cause polyuria.The patient is impaired because of self beta Cell of islet, glucose is not fully absorbed in the body, part enters blood (hyperglycemia), part excretes (the glycosuria name of disease produces thus) with urine, sick body tired gradually become thin (losing weight), impel patient to increase food-intake (polyphagia), run off because of the polydipsia polyuria is a large amount of again but enter the glucose that the food of human body is decomposed to form.Each side's reciprocal causation like this, add fuel to the flames, form vicious cycle, the state of an illness increases the weight of day by day.Radix Puerariae is clinical blood-sugar lowering tcm drug commonly used, and the existing hypoglycemic effect of the diabetic to take preparation that promotes the production of body fluid of the present invention again can fast born fluid, alleviate thirsty, in time cut off the vicious cycle chain, alleviate polydipsia, polyuria symptom synchronously, diabetes are had the certain auxiliary treatment or the effect of prevention.
Advantage of the present invention
1, plant Radix Puerariae, the Herba Menthae safety non-toxic of the present invention's application, integration of edible and medicinal herbs, the raw material abundance, cheap, it is easily simple to prepare its product (medicine or health food promote the production of body fluid), taking convenience, suitable crowd is very wide.
2, Radix Puerariae, the Herba Menthae powder product that adds preparations such as an amount of sweeting agent, citric acid has sour-sweet algefacient peculiar flavour.Good palatability when taking, application person's compliance is good, generally likes edible this quasi drugs and health food.
3, the present invention preparation promote the production of body fluid medicine or food to go on business, travel particularly in the open air, the personnel of desert work, life and military personnel and because of insufficient water sources or drinking-water, urination inconvenience person; normal trouble xerostomia, ozostomia person; the diabetics of thirsty polydipsia; promoting the production of body fluid to quench thirst immediately after taking; alleviate the xerostomia symptom rapidly, obtain the health-care effect of swallowing saliva health preserving simultaneously.
Embodiment 1
Dry Radix Puerariae, Herba Menthae are pulverized, sieve with universal mill respectively, with two medicines mix homogeneously by weight ratio, sterilization, get 50～98% mixed-powder and add adjuvant such as binding agent, sweeting agent or excipient (2～50%) with the common process mixing, make dried granule, dry again, promptly get granule.
Embodiment 2
With the dried granule that embodiment 1 obtains, dry again, compacting promptly gets tablet in flakes.
Embodiment 3
With the dried granule that embodiment 1 obtains, dry again, incapsulate, make capsule.
Embodiment 4
Use pulverizing mill (Chinese medicine cell grade disintegrating apparatus) to become≤70 microns micropowder respectively dry Radix Puerariae, Herba Menthae, press embodiment 1～3 described method, be made as granule, tablet or capsule respectively with comminution by gas stream.
Embodiment 5
The week * *, the man, 55 years old, the private prosecution xerostomia was month surplus, the normal sense of nearly section halitosis, hoarseness is got up every night and is drunk water.All normal with 2 hours after the meal blood glucose on an empty stomach through check, get rid of diabetic symptom.System causes that body fluid is short and causes in the mouth dry thirsty because of gastric heat.With the Radix Puerariae Herba Menthae sheet that promotes the production of body fluid, each 1, oral at any time, consumption per day 6～15g.Promptly feel saliva increasing from taking first, thirsty alleviation, the whole day oral cavity is moistening comfortable.Logotype one all xerostomias, halitosis transference cure.After this decrement is only obeyed several pieces every day, and continuous clothes were consolidated curative effect on the 10th.
Embodiment 6
Promote the production of body fluid preparation and the health food that will contain Radix Puerariae, Herba Menthae powder preparation are distributed to voluntary trier 86 people, xerostomia person 35 people (hold concurrently halitosis person 20 people) wherein, requirement is promoted the production of body fluid and is wet one's whistle and curiosity seeker 51 people (hold concurrently and suffer from glycosuria patient 19 people), 14～82 years old age, repeatedly take every day, all takes effect then and there, and body fluid is from gushing in edible back one minute of the private prosecution, the oral cavity is moistening comfortable, promotes the production of body fluid to increase saliva effective percentage 100%.Xerostomia, halitosis symptom all disappeared at 5～10 days.The xerostomia symptom is greatly improved behind the diabetic to take, and amount of drinking water reduces significantly, and is very nearly the same with ordinary person.Have two juvenile these nothings to feel yearningly, pursue " having a taste of what is just in season " because of curiosity and serve on several pieces, allegation saliva continuously outflows, and does not have the swallowing saliva custom again, is difficult to adaptation for the moment, allows it eat salty peppery food, can contain salivary flow.
Claims (10)
1, a kind of preparation that promotes the production of body fluid that promotes salivation is characterized in that it is to comprise that following bulk drugs makes:
Radix Puerariae 30～200 Herba Menthaes 1～15.
2, the preparation that promotes the production of body fluid according to claim 1 is characterized in that the weight proportion of described raw material is:
Radix Puerariae 70～150 Herba Menthaes 2～10.
3, the preparation that promotes the production of body fluid according to claim 1 is characterized in that the weight proportion of described raw material is:
Radix Puerariae 100 Herba Menthaes 5.
4, according to claim 1, the 2 or 3 described preparations that promote the production of body fluid, it is characterized in that the preparation method of its crude drug comprises the following steps:
A, with Radix Puerariae clean, run through, cut into slices, drying;
B, use disintegrating apparatus---to comprise universal mill or pulverizing mill---dry Radix Puerariae sheet to be processed into powder, it is above until cell wall breaking level micropowder wherein to comprise the fine powder level;
C, the Radix Puerariae powder is sieved;
D, the dry Herba Menthae after will concocting are prepared as powder according to b, c method, sieve;
E, Radix Puerariae, mixing, the sterilization, stand-by by weight ratio of Herba Menthae powder that c, d are obtained.
5, the preparation that promotes the production of body fluid according to claim 4 is characterized in that and the mixed-powder of sterilized Radix Puerariae and Herba Menthae can be adopted common process and adjuvant make clinical acceptable medicinal preparation for oral administration or health food.
6, the preparation that promotes the production of body fluid according to claim 5 is characterized in that described adjuvant comprises excipient or food, and they contain water, alcohol, binding agent, filler, sweeting agent, flavoring agent or food additive.
7,, it is characterized in that described pharmaceutical dosage form or health food kind comprise tablet, powder, capsule, granule, oral liquid, syrup, beverage according to claim 5 or the 6 described preparations that promote the production of body fluid.
8, according to claim 1, the 2 or 3 described application of preparation in the medicine of preparation promotion salivation, treatment or prevention halitosis or xerostomia of promoting the production of body fluid.
9, according to claim 1, the 2 or 3 described application of preparation in the medicine of preparation promotion salivation, adjuvant therapy of diabetes of promoting the production of body fluid.
10, promote salivation, have the application in " moistening and cleaning throat " health care foods in preparation according to claim 1, the 2 or 3 described preparations that promote the production of body fluid.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610079648 CN1879696A (en) | 2006-05-01 | 2006-05-01 | Preparation for promoting secretion of saliva, its preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610079648 CN1879696A (en) | 2006-05-01 | 2006-05-01 | Preparation for promoting secretion of saliva, its preparation method and application |
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| CN1879696A true CN1879696A (en) | 2006-12-20 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854538A (en) * | 2017-11-10 | 2018-03-30 | 厦门敖依生物科技有限公司 | A kind of Chinese medicine for treating dry |
| CN112043757A (en) * | 2020-09-22 | 2020-12-08 | 上海中医药大学附属曙光医院 | Health-preserving coffee and traditional Chinese medicine composition for people with qi-yin deficiency type metabolic syndrome |
-
2006
- 2006-05-01 CN CN 200610079648 patent/CN1879696A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107854538A (en) * | 2017-11-10 | 2018-03-30 | 厦门敖依生物科技有限公司 | A kind of Chinese medicine for treating dry |
| CN112043757A (en) * | 2020-09-22 | 2020-12-08 | 上海中医药大学附属曙光医院 | Health-preserving coffee and traditional Chinese medicine composition for people with qi-yin deficiency type metabolic syndrome |
| CN112043757B (en) * | 2020-09-22 | 2022-03-25 | 上海中医药大学附属曙光医院 | Health-preserving coffee and traditional Chinese medicine composition |
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