CN1861062A - Medicine composition used for fish or other aquatic livings and its prepn. method - Google Patents
Medicine composition used for fish or other aquatic livings and its prepn. method Download PDFInfo
- Publication number
- CN1861062A CN1861062A CN 200610012853 CN200610012853A CN1861062A CN 1861062 A CN1861062 A CN 1861062A CN 200610012853 CN200610012853 CN 200610012853 CN 200610012853 A CN200610012853 A CN 200610012853A CN 1861062 A CN1861062 A CN 1861062A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- etamsylate
- fish
- lactic acid
- benzalkonium bromide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A composite medicine for treating the hemorrhage of aquatic living things (fish, shrimp, crab, turtle, eel, etc) is prepared from benzalkonium bromide, etamsylate, lactic acid and water through proportional mixing.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition that is used for aquatic biological, this pharmaceutical composition is mainly used in the control hemorrhagic disease of fish.
Background technology
Development along with the cause of breeding fish, fish disease becomes the higher Ctenopharyngodon idellus of the serious problems in the production, particularly economic benefit day by day, because its premunition is relatively poor, viral, bacterial diseasees such as hemorrhage, enteritis, gill rot, red skin very easily take place, and cause economic loss in various degree.
Hemorrhagic disease of grass carp is one of maximum infectious disease of Ctenopharyngodon idellus raising stage harm, be popular in the whole nation each culture the area, in the Yangtze river basin and ground such as Guangdong, Guangxi, Fujian the most serious, main epidemic season is 6～JIUYUE, optimum morbidity water temperature is more than 27 ℃.The popular object of hemorrhagic disease is mainly the Ctenopharyngodon idellus of 6～10cm, and the Ctenopharyngodon idellus mortality rate is general 30%～50% then, and Gao Shikeda 60%～80% also can infect above Ctenopharyngodon idellus of an age.Lower jaw, the gill cover and abdominal part pale red ecchymosis can appear in ill Ctenopharyngodon idellus, pop-eyed performance, whole-body muscle takes on a red color when serious, the gill filament is hemorrhage or be pale asphyxia, hemorrhage speckle appears in internal organs and tissue, intestinal hyperemia, but intestinal wall is still flexible, not rotten to the corn, this point can be distinguished mutually with bacterial enteritis when medical diagnosis on disease.
The cause of disease of hemorrhagic disease of grass carp is GCRV (Grass carp reovirus), claims that again (Grass carp hemorrhage virus, GCV), the main method of preventing and treating on producing is vaccination to GCHV at present.Having yet and use iodine noodles served with soy sauce, sesame butter, etc. powder, the grass disease fish of throwing something and feeding, and use other routine disinfection agent such as sodium dichloro cyanurate etc., though certain curative effect is arranged, is not too desirable.The control of hemorrhagic disease of grass carp is puzzlement raiser's a a great problem always.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition that is used for aquatic biological, this pharmaceutical composition can fast and effeciently be prevented and treated hemorrhagic disease of grass carp.
The present invention also aims to provide this preparation of drug combination method.
Pharmaceutical composition of the present invention is to be main active with the benzalkonium bromide, is equipped with other hemostasis factors and forms, and its component and content are:
Benzalkonium bromide 5%～45%
Etamsylate 5%～20%
Lactic acid 0.1%～1%
Water surplus,
Wherein all percents are percetage by weight.
The concrete preparation method of pharmaceutical composition of the present invention is that water is heated to 35 ℃, and order adds etamsylate, benzalkonium bromide, lactic acid, makes after stirring.
After the pharmaceutical composition of making after stirring was preferably in and keeps 1h in the container, discharging was packed again.
Pharmaceutical composition of the present invention is mainly used in the control hemorrhagic disease of grass carp.
The present invention is through behind the repeatedly control experiment of multiple medicine, a kind of more satisfactory pharmaceutical composition of hemorrhagic disease of grass carp of preventing and treating that screens.Wherein, benzalkonium bromide is a kind of quaternary cationics class wide-spectrum bactericide; Etamsylate can strengthen the resistance of blood capillary, reduces the permeability of blood capillary, and strengthens hematoblastic aggregation and adhesiveness, promotes platelet to discharge the blood coagulation activity material, shortens clotting time, reaches haemostatic effect; Lactic acid is a kind of phagostimulant.
The present invention is by the combination of benzalkonium bromide and etamsylate, hydrophobic group in its molecular structure and hydrophilic group can penetrate into the lipoids and the protein layer of cell serous coat respectively, the permeability of antibacterial is changed, cause the intracellular matter of antibacterial to run off and death.
Pharmaceutical composition of the present invention is faint yellow transparent thick liquid, it is at the various hemorrhagic disease that caused by antibacterial, virus of aquatic biological and the new product of developing, hemorrhagic disease to various fishes, shrimp, Eriocheir sinensis, Trionyx sinensis Wiegmann, Monopterus albus (Zuiew) etc. all has better curative effect, also can be used for raising together with in the ponds of fish, shrimp, Eriocheir sinensis etc., significant curative effect is arranged through clinical practice.
Pharmaceutical composition of the present invention has hemostasis, germ-resistant effect, wide spectrum, noresidue, has no side effect, and molecular structure stabilized, lasting effect is long.
The present invention is a kind of fluid product, and is easy to use.Using method: during the fingerling soaking therapy, drug level 5ppm, processing time 5～10min, during the full pool spilling head treatment, drug level is 50mL/ mu～75mL/ mu.
The specific embodiment
Embodiment 1
Prescription:
Benzalkonium bromide 12%
Etamsylate 8%
Lactic acid 0.1%
Water 79.9%.
Method for making:
Water is heated to 35 ℃, adds etamsylate, be stirred to dissolving fully, add benzalkonium bromide, stir 30min, add phagostimulant lactic acid then, restir 30min places reactor to keep 1h, and discharging is packaged to be finished product.
Embodiment 2
Prescription:
Benzalkonium bromide 20%
Etamsylate 10%
Lactic acid 0.2%
Water 69.8%.
Method for making:
Water is heated to 35 ℃, adds etamsylate, be stirred to dissolving fully, add benzalkonium bromide, stir 30min, add phagostimulant lactic acid then, restir 30min places reactor to keep 1h, and discharging is packaged to be finished product.
Embodiment 3
Prescription:
Benzalkonium bromide 25%
Etamsylate 15%
Lactic acid 0.5%
Water 59.5%.
Method for making is with embodiment 1.
Embodiment 4
Prescription:
Benzalkonium bromide 40%
Etamsylate 20%
Lactic acid 1%
Water 39%.
Method for making is with embodiment 1.
Claims (4)
1, a kind of pharmaceutical composition that is used for aquatic biological, its component and content are:
Benzalkonium bromide 5%～45%
Etamsylate 5%～20%
Lactic acid 0.1%～1%
Water surplus,
All percents are percetage by weight.
2, claim 1 preparation of drug combination method is that water is heated to 35 ℃, and order adds etamsylate, benzalkonium bromide, lactic acid, stirs and makes.
3, preparation of drug combination method according to claim 2, behind the pharmaceutical composition maintenance 1h that it is characterized in that making, discharging is packed again.
4, the application of claim 1 pharmaceutical composition on the control hemorrhagic disease of grass carp.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610012853 CN1861062A (en) | 2006-06-14 | 2006-06-14 | Medicine composition used for fish or other aquatic livings and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610012853 CN1861062A (en) | 2006-06-14 | 2006-06-14 | Medicine composition used for fish or other aquatic livings and its prepn. method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1861062A true CN1861062A (en) | 2006-11-15 |
Family
ID=37388649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610012853 Pending CN1861062A (en) | 2006-06-14 | 2006-06-14 | Medicine composition used for fish or other aquatic livings and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1861062A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734153A (en) * | 2014-01-20 | 2014-04-23 | 王德昌 | Water-soluble biological insecticide containing active abamectin and preparation method of biological insecticide |
| ES2734584A1 (en) * | 2018-05-22 | 2019-12-10 | Dobecure S L | ETHAMSYLATE FOR THE TREATMENT OF INFECTIONS BY HERPES VIRUSES (Machine-translation by Google Translate, not legally binding) |
-
2006
- 2006-06-14 CN CN 200610012853 patent/CN1861062A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734153A (en) * | 2014-01-20 | 2014-04-23 | 王德昌 | Water-soluble biological insecticide containing active abamectin and preparation method of biological insecticide |
| CN103734153B (en) * | 2014-01-20 | 2016-04-27 | 王德昌 | A kind of water-soluble biological insecticide containing active Avermectin and preparation method thereof |
| ES2734584A1 (en) * | 2018-05-22 | 2019-12-10 | Dobecure S L | ETHAMSYLATE FOR THE TREATMENT OF INFECTIONS BY HERPES VIRUSES (Machine-translation by Google Translate, not legally binding) |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Langdon et al. | Outbreaks of an EHNV-like iridovirus in cultured rainbow trout, Salmo gairdneri Richardson, in Australia. | |
| CN1644077A (en) | Plant additive premixed forage for aquatic culture and bait therefrom | |
| CN104969887A (en) | Fishpond fish farming method | |
| Atray et al. | Ultrasonographic diagnosis and surgical management of double intestinal intussusception in 3 dogs | |
| US20200236975A1 (en) | Probiotic bacteria for fish | |
| CN107412256A (en) | Disease is treated with poly- N acetyl glucosamines nanofiber | |
| CN101759259A (en) | Shuanghuanglian oral liquid for aquatic product culture and a preparing method thereof | |
| CN1861062A (en) | Medicine composition used for fish or other aquatic livings and its prepn. method | |
| CN1762460A (en) | The Chinese herbal medicine compound prescription of control seawater fish shield balantidiasis | |
| CN1632105A (en) | Bacillus subtilis preparation | |
| CN101584704A (en) | Medicinal application of medicinal salt or derivative of heparin and low molecular heparin | |
| CN105497898B (en) | MAPK signal pathway inhibitors are as the application for preparing treatment cystic echinococcosis drug | |
| CN101708187B (en) | Dry powder preparation for preventing and controlling saprolegniasis of aquatic animals and preparation method thereof | |
| CN105265364A (en) | Fishpond fish farming method | |
| Doane et al. | Well-differentiated liposarcoma in a bonnet macaque (Macaca radiata) | |
| CN102037917B (en) | Application of bdellovibrio sp. leech plasmid bacterium solution in cultivating penaeus monodon | |
| CN1090491A (en) | Prevent and treat pyemic method | |
| CN1739530A (en) | Aspirin-Al-lysine for injection | |
| CN107920994A (en) | The composition and method of lamellar body for therapeutic purposes | |
| CN1299684C (en) | Aquatic animal antibacterial agent and preparation method thereof | |
| CN101810638B (en) | Preparation method of endogenous interferon inducer injection and nanometer microencapsulation solution | |
| CN1899299A (en) | Chitosan powder medicine for fishing and its producing process | |
| CN1943599A (en) | Eye medicine for treating and preventing and curing cataract and its preparing method | |
| CN109966289A (en) | Application of the dephnetin in anti-chicken coccidiasis | |
| CN1062737C (en) | Medicament for preventing and curing several fish diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |