CN1810278A - 一种治疗颈、腰椎病中药的肠溶包衣组合物 - Google Patents
一种治疗颈、腰椎病中药的肠溶包衣组合物 Download PDFInfo
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- CN1810278A CN1810278A CN 200510005001 CN200510005001A CN1810278A CN 1810278 A CN1810278 A CN 1810278A CN 200510005001 CN200510005001 CN 200510005001 CN 200510005001 A CN200510005001 A CN 200510005001A CN 1810278 A CN1810278 A CN 1810278A
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Abstract
Description
time(min) | pH | 1.10mg/cm2 | 8.44mg/cm2 | 15.22mg/cm2 |
5 | 1.2 | 0.21 | 0.15 | 0.16 |
15 | 1.2 | 0.26 | 0.44 | 0.26 |
30 | 1.2 | 0.71 | 1.04 | 0.38 |
60 | 1.2 | 4.43 | 1.55 | 0.84 |
90 | 1.2 | 8.78 | 2.75 | 1.7 |
120 | 1.2 | 9.13 | 6.45 | 4.03 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
5 | 81.7 | 87.6 | 81.8 | 83.7 | 85.6 | 87.3 | 84.6 | 2.6 |
10 | 86.8 | 88.1 | 89.3 | 86.5 | 89.3 | 90.6 | 88.4 | 1.6 |
20 | 87.5 | 87.9 | 91.0 | 87.6 | 90.4 | 90.6 | 89.2 | 1.6 |
30 | 86.2 | 87.4 | 91.7 | 88.0 | 89.7 | 89.8 | 88.8 | 2.0 |
45 | 87.0 | 87.4 | 91.4 | 87.5 | 89.7 | 89.9 | 88.8 | 1.8 |
60 | 87.5 | 88.9 | 92.0 | 86.4 | 90.4 | 91.0 | 89.4 | 2.2 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
5 | 75.8 | 72.3 | 77.5 | 71.6 | 74.4 | 72.9 | 74.1 | 2.2 |
10 | 89.5 | 88.8 | 93.2 | 88.3 | 91.2 | 89.1 | 90.0 | 1.8 |
20 | 93.6 | 94.9 | 96.6 | 93.5 | 95.8 | 95.3 | 95.0 | 1.2 |
30 | 93.3 | 95.0 | 96.3 | 93.9 | 96.9 | 95.4 | 95.1 | 1.4 |
45 | 93.0 | 94.2 | 96.8 | 93.2 | 96.8 | 94.1 | 94.7 | 1.7 |
60.0 | 92.2 | 93.8 | 96.2 | 92.0 | 96.9 | 94.7 | 94.3 | 2.0 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 68.4 | 70.0 | 71.2 | 71.1 | 68.8 | 70.4 | 70.0 | 1.2 |
10 | 88.5 | 89.6 | 92.0 | 88.0 | 88.7 | 91.5 | 89.7 | 1.7 |
20 | 94.4 | 94.7 | 99.7 | 94.2 | 96.1 | 98.6 | 96.3 | 2.3 |
30 | 95.4 | 95.1 | 99.0 | 94.1 | 97.1 | 100.7 | 96.9 | 2.5 |
45 | 94.5 | 94.4 | 100.5 | 95.3 | 96.1 | 100.3 | 96.9 | 2.8 |
60 | 94.9 | 94.6 | 99.2 | 94.7 | 95.8 | 100.1 | 96.6 | 2.4 |
time(min) | pH | 2.20mg/cm2 | 13.25mg/cm2 | 24.45mg/cm2 |
5 | 1.2 | 0.17 | 0.16 | 0.21 |
15 | 1.2 | 0.25 | 0.25 | 0.5 |
30 | 1.2 | 0.71 | 0.31 | 0.6 |
60 | 1.2 | 4.83 | 0.86 | 0.77 |
90 | 1.2 | 8.38 | 1.49 | 0.87 |
120 | 1.2 | 8.63 | 3.17 | 1.15 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 88.7 | 83.4 | 86.5 | 87.9 | 81.8 | 88.3 | 86.1 | 2.9 |
10 | 89.4 | 90.3 | 93.2 | 94.9 | 92.1 | 92.1 | 92.0 | 2.0 |
20 | 91.0 | 91.6 | 94.3 | 94.0 | 92.7 | 92.6 | 92.7 | 1.3 |
30 | 89.7 | 93.1 | 93.6 | 94.3 | 92.7 | 92.4 | 92.6 | 1.6 |
45 | 90.3 | 92.1 | 93.9 | 94.8 | 94.5 | 93.0 | 93.1 | 1.7 |
60 | 89.7 | 92.1 | 93.6 | 93.9 | 94.1 | 91.6 | 92.5 | 1.7 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 78.0 | 78.8 | 81.6 | 83.2 | 78.4 | 80.5 | 80.1 | 2.0 |
10 | 91.0 | 91.4 | 91.6 | 93.9 | 95.2 | 92.3 | 92.6 | 1.6 |
20 | 93.1 | 93.1 | 93.8 | 94.3 | 98.8 | 95.0 | 94.7 | 2.2 |
30 | 94.7 | 93.6 | 93.7 | 94.8 | 99.9 | 95.4 | 95.3 | 2.3 |
45 | 94.0 | 93.8 | 93.2 | 94.6 | 99.7 | 95.4 | 95.1 | 2.4 |
60.0 | 93.9 | 92.9 | 93.3 | 95.6 | 98.7 | 94.7 | 94.9 | 2.1 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 68.7 | 73.1 | 71.0 | 68.6 | 73.6 | 76.0 | 71.8 | 2.9 |
10 | 90.7 | 91.4 | 89.7 | 88.1 | 93.2 | 92.9 | 91.0 | 1.9 |
20 | 98.9 | 96.2 | 98.1 | 95.5 | 99.9 | 96.7 | 97.6 | 1.7 |
30 | 100.0 | 95.9 | 97.6 | 97.2 | 100.1 | 97.2 | 98.0 | 1.7 |
45 | 98.9 | 96.1 | 97.8 | 97.6 | 100.3 | 96.8 | 97.9 | 1.5 |
60 | 100.7 | 96.3 | 98.6 | 96.3 | 100.5 | 95.8 | 98.0 | 2.2 |
time(min) | pH | 0.55mg/cm2 | 4.44mg/cm2 | 7.89mg/cm2 |
5 | 1.2 | 0.11 | 0.03 | 0.4 |
15 | 1.2 | 0.23 | 0.27 | 0.49 |
30 | 1.2 | 0.77 | 0.39 | 0.62 |
60 | 1.2 | 4.36 | 0.88 | 0.7 |
90 | 1.2 | 8.15 | 1.72 | 0.81 |
120 | 1.2 | 9.62 | 4.01 | 0.99 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 77.7 | 81.2 | 76.9 | 77.6 | 76.5 | 82.8 | 78.8 | 2.6 |
10 | 88.3 | 85.2 | 84.6 | 88.4 | 89.6 | 86.2 | 87.0 | 2.0 |
20 | 89.4 | 85.2 | 85.2 | 89.3 | 92.1 | 85.4 | 87.8 | 2.9 |
30 | 89.6 | 86.8 | 85.6 | 90.2 | 92.0 | 86.4 | 88.5 | 2.5 |
45 | 89.4 | 86.2 | 85.5 | 90.5 | 90.2 | 86.7 | 88.1 | 2.2 |
60 | 89.3 | 86.9 | 85.2 | 89.9 | 91.3 | 85.2 | 87.9 | 2.6 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 77.2 | 76.1 | 74.3 | 78.2 | 75.7 | 77.6 | 76.5 | 1.4 |
10 | 92.9 | 91.9 | 89.1 | 92.4 | 90.0 | 90.9 | 91.2 | 1.5 |
20 | 96.3 | 94.1 | 90.4 | 96.3 | 92.0 | 92.4 | 93.6 | 2.4 |
30 | 95.2 | 93.7 | 90.3 | 93.9 | 90.9 | 91.5 | 92.6 | 2.0 |
45 | 94.8 | 92.2 | 89.7 | 93.7 | 89.3 | 89.7 | 91.6 | 2.3 |
60 | 92.8 | 91.5 | 88.8 | 92.7 | 88.1 | 88.8 | 90.4 | 2.1 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 67.1 | 64.3 | 67.3 | 62.8 | 63.3 | 68.0 | 65.5 | 2.3 |
10 | 89.2 | 84.8 | 87.0 | 84.6 | 84.7 | 88.7 | 86.5 | 2.1 |
20 | 99.5 | 94.0 | 94.3 | 95.7 | 95.5 | 97.7 | 96.1 | 2.1 |
30 | 99.4 | 95.5 | 95.2 | 95.5 | 95.3 | 98.6 | 96.6 | 1.9 |
45 | 100.5 | 96.1 | 94.4 | 96.0 | 96.0 | 97.8 | 96.8 | 2.1 |
60 | 100.3 | 95.2 | 95.8 | 95.9 | 96.9 | 98.5 | 97.1 | 2.0 |
time(min) | pH | 2.35mg/cm2 | 10.67mg/cm2 | 19.97mg/cm2 |
5 | 1.2 | 0.26 | 0.18 | 0.42 |
15 | 1.2 | 0.24 | 0.26 | 0.47 |
30 | 1.2 | 0.69 | 0.32 | 0.64 |
60 | 1.2 | 3.41 | 0.89 | 0.72 |
90 | 1.2 | 7.73 | 1.67 | 0.81 |
120 | 1.2 | 8.48 | 4.96 | 1.01 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 81.5 | 79.2 | 78.5 | 83.2 | 78.2 | 82.5 | 80.5 | 2.2 |
10 | 92.2 | 92.1 | 88.7 | 89.9 | 90.4 | 94.6 | 91.3 | 2.1 |
20 | 94.2 | 93.8 | 91.2 | 92.0 | 93.6 | 95.8 | 93.4 | 1.6 |
30 | 94.7 | 93.0 | 91.1 | 91.2 | 93.0 | 95.4 | 93.1 | 1.8 |
45 | 94.7 | 93.6 | 90.9 | 90.6 | 93.2 | 95.5 | 93.1 | 2.0 |
60 | 94.2 | 94.0 | 90.5 | 91.1 | 93.4 | 95.7 | 93.2 | 2.0 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 73.9 | 75.3 | 76.1 | 74.2 | 72.9 | 75.0 | 74.6 | 1.1 |
10 | 90.7 | 90.6 | 91.1 | 90.2 | 92.1 | 88.5 | 90.5 | 1.2 |
20 | 95.6 | 95.2 | 92.8 | 94.4 | 98.4 | 92.4 | 94.8 | 2.2 |
30 | 96.3 | 95.3 | 94.3 | 93.7 | 98.2 | 93.0 | 95.1 | 1.9 |
45 | 95.9 | 95.1 | 93.5 | 94.0 | 98.0 | 91.3 | 94.6 | 2.3 |
60 | 96.6 | 96.1 | 92.6 | 94.4 | 98.2 | 91.7 | 94.9 | 2.5 |
∑Q(%) | 1 | 2 | 3 | 4 | 5 | 6 | 平均值 | SD(%) |
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
5 | 62.8 | 66.8 | 67.9 | 66.5 | 64.5 | 65.7 | 65.7 | 1.8 |
10 | 85.7 | 87.7 | 91.2 | 86.8 | 87.8 | 86.2 | 87.6 | 2.0 |
20 | 96.2 | 96.2 | 100.5 | 97.2 | 98.4 | 94.5 | 97.2 | 2.1 |
30 | 98.4 | 97.5 | 100.2 | 97.2 | 98.8 | 96.3 | 98.1 | 1.4 |
45 | 97.2 | 97.1 | 100.2 | 97.3 | 99.2 | 94.7 | 97.6 | 1.9 |
60 | 97.7 | 97.2 | 102.2 | 96.4 | 99.2 | 94.9 | 97.9 | 2.5 |
给药后血流增加量ml/min0 | ||||||
时间(min) | 生理盐水 | 根痛平颗粒 | 甲基丙烯酸树脂包衣肠溶片 | 羟丙甲纤维素酞酸酯包衣肠溶颗粒 | 虫胶包衣肠溶微丸胶囊 | 醋酸纤维素酞酸酯包衣多单元肠溶片 |
给药前 | 23.6±7.1 | 36.1±14.3 | 25.3±5.5 | 24.1±5.6 | 32.1±14.8 | 26.2±12.5 |
5min | 1.3±2.4 | 2.7±9.0 | / | / | / | / |
10min | 1.0±1.2 | 14.1±5.7 | / | / | / | / |
15min | / | / | 1.6±5.7 | 1.1±7.0 | 2.6±9.6 | 1.7±5.4 |
20min | 4.3±2.8 | 18.7±8.3 | / | / | / | / |
30min | 2.8±2.3 | 17.0±6.1 | 2.9±4.4 | 2.8±6.3 | 4.8±8.8 | 3.7±8.3 |
60min | 3.6±2.7 | 10.0±7.7 | 16.7±10.8 | 15.9±8.5 | 13.1±8.1 | 16.1±10.8 |
90min | / | / | 26.0±6.2 | 26.7±9.7 | 21.6±8.3 | 24.6±5.3 |
120min | / | / | 25.2±5.1 | 24.8±9.8 | 31.2±9.1 | 27.1±7.3 |
180min | / | / | 23.4±7.8 | 27.5±7.7 | 28.3±5.9 | 22.1±5.2 |
240min | / | / | 13.1±6.8 | 14.6±7.3 | 12.2±4.9 | 14.7±8.4 |
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Cited By (3)
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CN104825503A (zh) * | 2015-04-24 | 2015-08-12 | 成都汇智远景科技有限公司 | 东革阿里提取物肠溶片 |
CN105968385A (zh) * | 2016-05-31 | 2016-09-28 | 上海浦力膜制剂辅料有限公司 | 一种虫胶水分散体的制备方法及其在包衣上的应用 |
CN110251478A (zh) * | 2019-05-15 | 2019-09-20 | 浙江维康药业股份有限公司 | 一种用于微滴丸的耐高温肠溶包衣工艺 |
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CN87104143A (zh) * | 1987-06-06 | 1988-12-28 | 连云港制药厂 | 有色肠溶薄膜衣片包衣溶液处方 |
DK0386967T3 (da) * | 1989-03-10 | 1995-11-20 | Yamanouchi Pharma Co Ltd | Coatingmateriale til styring af lægemiddelafgivelse i langtidsvirkende formuleringer |
CN1042696C (zh) * | 1993-05-13 | 1999-03-31 | 江西南昌桑海制药厂 | 强力维c银翘片的薄膜包衣工艺 |
CN1090483C (zh) * | 1997-07-31 | 2002-09-11 | 谢理峰 | 钾镁缓释片及生产方法 |
UA73092C2 (uk) * | 1998-07-17 | 2005-06-15 | Брістол-Майерс Сквібб Компані | Таблетка з ентеросолюбільним покриттям і спосіб її приготування |
CN1353983A (zh) * | 2000-11-18 | 2002-06-19 | 唐修文 | 肠溶片包衣配制液及其制备方法 |
CN1296046C (zh) * | 2003-12-23 | 2007-01-24 | 广州市医药工业研究所 | 盐酸地尔硫䓬控释胶囊剂及其制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104825503A (zh) * | 2015-04-24 | 2015-08-12 | 成都汇智远景科技有限公司 | 东革阿里提取物肠溶片 |
CN105968385A (zh) * | 2016-05-31 | 2016-09-28 | 上海浦力膜制剂辅料有限公司 | 一种虫胶水分散体的制备方法及其在包衣上的应用 |
CN110251478A (zh) * | 2019-05-15 | 2019-09-20 | 浙江维康药业股份有限公司 | 一种用于微滴丸的耐高温肠溶包衣工艺 |
CN110251478B (zh) * | 2019-05-15 | 2021-06-18 | 浙江维康药业股份有限公司 | 一种用于微滴丸的耐高温肠溶包衣工艺 |
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