CN1766095A - Probiotic composite enzyme production method - Google Patents
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- CN1766095A CN1766095A CN 200510103133 CN200510103133A CN1766095A CN 1766095 A CN1766095 A CN 1766095A CN 200510103133 CN200510103133 CN 200510103133 CN 200510103133 A CN200510103133 A CN 200510103133A CN 1766095 A CN1766095 A CN 1766095A
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Abstract
The invention relates to a production method for benefit fungus composite enzyme as powder, tablet or capsule riched in benefit microbial fungi, such as, aspergillus, yeast, lactobacillus and bacillus, and hydrolase, such as saccharifying enzyme, lipase and protease, which comprises: mixing material with starch, glucose, ferment juice, functional group and other supplementary materials, second fermenting, pinning, and tabletting. This product can maintenance the microecological balance of digestive system, enhances immunocompetence of sick mucous membrane system, reduces 50% cost, and prolongs quality assured time to three years.
Description
Technical field
The present invention relates to a kind of production method of probiotic composite enzyme, belong to the microbial fermentation processes of biological field.
Background technology
Probiotic bacterium (Probiotics) claim feeding micro-ecological conditioning agent or probiotics again.As far back as nineteen sixty-five, two scientist Lilly and Stillwell at first define: probiotic bacterium is a kind of microorganism secretion, stimulates the material of another kind of microorganism growth, represents the symbiotic meaning with Greek Probiotics.This is actually a kind of misunderstanding, and the meta-bolites of a kind of microorganism not only can promote the growth of certain micro-organisms, can also suppress other microbial growths.People find that through research and the practice in twenties years probiotic bacterium all responds to these two kinds of effects.Therefore scientist Fuller in 1989 probiotic bacterium from be newly defined as the eubiosis that can promote intestinal flora, to the microbial preparation of the work of host's beneficial effect.Microorganism feed addictive and microbiological feed have been developed on this basis again.(horse is cleer and peaceful etc., Chinese microecology magazine, 2000,5)
Probiotic composite enzyme is to use the microecology theory, and multiple digestive ferment and probiotics are organically combined by a certain percentage, can effectively promote metabolism, the accelerating growth of animal, production performance and the anti-stress level of raising animal.Probiotic composition has no side effect because of it is distinctive, can regulate the human body micro-flora, promotes health, becomes the focus in the functional food research day by day.(2002.5.1 submits to for Li Yan, Northeast Agricultural University's Master's thesis)
Along with the lifting of people's living standard, unconsciously, probiotic bacterium (Probiotics) hygiene has passed to China from Japan and America and Europe for a long time in vogue.A kind of probiotic composite enzyme from Japanese import is arranged at present, steady quality, to safeguarding the Digestive tract microecological balance, there is significant booster action in the consumer groups of suitable domestic market.To maldigestion, gastrointestinal disorder persons such as chronic diarrhoea have better curative effect.But because its cost height, the quality guaranteed period is low, and mouthfeel is poor, can't satisfy the needs of domestic market.
Summary of the invention
The objective of the invention is (to purchase in Japanese ferment world society and day this microbiological industry of island proper Co., Ltd. with the import probiotic composite enzyme, trade(brand)name BAIEMU-KOSO) is raw material, develop low, the long quality-guarantee period of cost, and the result of treatment product innovation identical with raw material, to satisfy the needs of domestic market.
The production method of probiotic composite enzyme of the present invention is to be that raw material carries out Secondary Fermentation with above-mentioned spissated probiotic composite enzyme, the probiotic composite enzyme pulvis, tablet or the capsule that obtain.
The present invention is a raw material with spissated probiotic composite enzyme, by Secondary Fermentation, success to produce curative effect identical with the raw material probiotic composite enzyme, but cost is low, long quality-guarantee period, probiotic composite enzyme product that mouthfeel is good.
Concentrated probiotics prozyme raw material used in the present invention is rich in beneficial microbe colony and a large amount of lytic enzymes such as saccharifying enzyme, lipase and proteolytic enzyme such as aspergillus, yeast, lactobacillus and genus bacillus.
The production process of probiotic composite enzyme of the present invention comprises the mixing of concentrated probiotics prozyme and auxiliary material, Secondary Fermentation and can, compressing tablet.
Used auxiliary material comprises and accounts for concentrated probiotics prozyme raw material and the starch of auxiliary material gross weight 28%-38% and the glucose of 20%-30% in the production process of the present invention.
Also add the ferment fruit juice that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight 1%-5% in the production process of the present invention.
Production process of the present invention is also added the functional factor that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight 5%-10%.(described functional factor is a prebiotics, is the chemical substance of the non-digestibility of a class, can selectively stimulate one or more probiotics growth and breedings in the intestines, plays and promotes host health and somatotrophic effect, and do not digested by the host.)
Functional factor used in the present invention comprises stachyose.
Production process of the present invention is: (one) concentrated probiotics prozyme raw material mixes with auxiliary material, i. will account for concentrated probiotics prozyme raw material and the starch of auxiliary material gross weight 30-35% and the glucose of 22-26%, in 18-20 ℃ of stirring and evenly mixing 40-50 minute, ii. add the concentrated probiotics prozyme raw material that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight 13-18%, in temperature 22-26 ℃ stirring and evenly mixing 35-45 minute, relative humidity 34-37%, iii. add the ferment fruit juice that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight 2-4%, in temperature 25-30 ℃ stirring and evenly mixing 25-30 minute, iv. add the functional factor stirring and evenly mixing that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight 6%-8%, v. add the concentrated probiotics prozyme raw material that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight 13-18%, in temperature 25-35 ℃ stirring and evenly mixing 28-34 minute, form raw mix, sieve.(2) fermentation, it is hundred grades sweathouse that the raw mix after sieving enters cleanliness factor, divides in fermentation box, fs, 0-48 hour, manually fully stir, temperature 35-40 ℃, subordinate phase, 48-68 hour, logical clean wind stirs, and per 8 hours once, temperature 27-35 ℃, phase III, 68-72 hour, static state, temperature 20-25 ℃.(3) can becomes pulvis, capsule or is pressed into tablet.
Beneficial effect of the present invention is:
1. the probiotic composite enzyme product by Secondary Fermentation has the remarkable effect of safeguarding the Digestive tract microecological balance.Measure through Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene, to maldigestion, gastrointestinal disorder person total effective rates such as chronic diarrhoea are 88.6%.And be cited as Chinese international subhealth state academy's successes symposial appointed product in 2002.The clinical experiment result of the Capital University of Medical Sciences shows that this product is taken through the patients after liver transplantation digestive tube, has effectively strengthened the immunologic function of its mucous membrane system, and prevention and the treatment early stage bacterium of post-transplantation and fungal infection are had tangible clinical meaning.(Li Ning etc., Chinese hospital infection magazine, 2002,12 (12), 898-900)
2. by probiotic composite enzyme pulvis, capsule or the tablet of Secondary Fermentation production, its cost has reduced about 50% than raw material itself.
3. by probiotic composite enzyme pulvis, capsule or the tablet of Secondary Fermentation production, its quality guaranteed period obviously prolongs than raw material, promptly extends to 3 years from 1 year.
4. by probiotic composite enzyme pulvis, capsule or the tablet of Secondary Fermentation production, the comfortable taste degree strengthens.
Embodiment
Further illustrate the present invention in the following embodiments, this does not limit the scope of the invention.
Embodiment one
Concentrated probiotics prozyme raw material is bought from Japanese ferment world society and day this microbiological industry of island proper Co., Ltd..
1. mixing of concentrated probiotics prozyme and auxiliary material:
Starch 320kg (account for raw mix gross weight 34.19%), glucose 250kg (account for raw mix gross weight 26.71%) are put into miniature stirrer, when 20 ℃ of temperature, stirred 48 minutes.The concentrated probiotics prozyme raw material of 146kg (account for raw mix gross weight 15.60%) 24 ℃ of addings, was stirred relative humidity 35% 42 minutes.Add 19.8kg (account for raw mix gross weight 2.1%) ferment fruit juice, 25 ℃ of temperature stirred 28 minutes.Add 47.2kg (account for raw mix gross weight 5.04%) functional factor stachyose, add then and add 153kg (account for raw mix gross weight 16.35%) concentrated probiotics prozyme raw material again, continue to stir 30 ℃ of temperature 27 minutes.Come out of the stove, cross 120 mesh sieves.
2. Secondary Fermentation:
Mixture after sieving is by stainless steel tank, enters cleanliness factor and be hundred grades sweathouse.Divide in fermentation box, each fermentation box is of a size of 30 * 20 * 8.The fermentation frame apart from ground high 1.5m, three layers, the layer apart from 0.5m, transverse distance 0.4m between fermentation box, 1.2m between frame and the frame, 37 ℃ of temperature, relative humidity 37%.
Fs (0-48 hour), manually fully stir 37 ℃ of temperature.Subordinate phase (the 48th hour the-the 68th hour), logical clean wind stirs, and per 8 hours are once, 30 ℃ of temperature.Phase III (the 68th hour the-the 72nd hour), static state, 22 ℃ of temperature.
3. can
Fermentation back directly can becomes capsule, is used for oral.
Embodiment two
Raw material sources are identical with embodiment one.
1. the preparation of fermentation raw material mixture:
Starch 680kg (account for raw mix gross weight 32.91%), glucose 540kg (account for raw mix gross weight 26.14%) are put into miniature stirrer, when 18 ℃ of temperature, stirred 45 minutes.The concentrated probiotics prozyme raw material of 340kg (account for raw mix gross weight 16.46%) 22 ℃ of addings, was stirred relative humidity 36% 38 minutes.Add 82.4kg (account for raw mix gross weight 3.99%) ferment fruit juice, 26 ℃ of temperature, churning time 27 minutes.Add 24.72kg (account for raw mix gross weight 1.20%) functional factor stachyose and 98.88kg (account for raw mix gross weight 4.79%) functional factor oligofructose.Add then and add 300kg (account for raw mix gross weight 14.52%) concentrated probiotics prozyme raw material again, continue to stir 28 ℃ of temperature 32 minutes.Come out of the stove, cross 150 mesh sieves.
2. Secondary Fermentation:
Mixture after sieving is transported between the clean area solid fermentation.Divide in fermentation box, each fermentation box is of a size of 50 * 30 * 20.The fermentation frame apart from ground high 1.3m, four layers, the layer apart from 0.7m, transverse distance 0.4m between fermentation box, 1.2m between frame and the frame, 37 ℃ of temperature, humidity 20-45%.
Fs (0-48 hour), manually fully stir 37 ℃ of temperature.Subordinate phase (the 48th hour the-the 68th hour), logical clean wind stirs, and per 8 hours are once, 30 ℃ of temperature.Phase III (the 68th hour the-the 72nd hour), static state, 22 ℃ of temperature.
3. can
Product after the fermentation directly is packaged into pockaged powder, available warm boiled water.
Embodiment three
Raw material sources are identical with embodiment one.
1. the preparation of fermentation raw material:
Starch 430kg (account for raw mix gross weight 32.38%), glucose 315kg (account for raw mix gross weight 23.72%) are put into electric blender, when 20 ℃ of temperature, stirred 40 minutes.The concentrated probiotics prozyme raw material of 195kg (account for raw mix gross weight 14.68%) 23 ℃ of addings, was stirred relative humidity 36% 45 minutes.Add 66.5kg (account for raw mix gross weight 5%) ferment fruit juice, 27 ℃ of temperature stirred 28 minutes.Add 90.5kg (account for raw mix gross weight 6.81%) functional factor stachyose.Add then and add 231kg (account for raw mix gross weight 17.39%) concentrated probiotics prozyme raw material again, continue to stir 34 ℃ of temperature 33 minutes.Come out of the stove, cross 100 mesh sieves.
2. Secondary Fermentation:
Mixture after sieving is by stainless steel tank, enters cleanliness factor and be hundred grades sweathouse.Divide in fermentation box, each fermentation box is of a size of 50 * 30 * 20.The fermentation frame apart from ground high 1.5m, three layers, the layer apart from 0.5m, transverse distance 0.4m between fermentation box, 1.2m between frame and the frame, 37 ℃ of temperature, humidity 20-45%.
Fs (0-48 hour), manually fully stir 37 ℃ of temperature.Subordinate phase (the 48th hour the-the 68th hour), logical clean wind stirs, and per 8 hours are once, 30 ℃ of temperature.Phase III (the 68th hour the-the 72nd hour), static state, 22 ℃ of temperature.
3. compacting is used for oral in flakes.
Embodiment four
Raw material sources are identical with embodiment one.
1. the preparation of fermentation raw material:
Starch 900kg (account for raw mix gross weight 30%), glucose 750kg (account for raw mix gross weight 25%) are put into miniature stirrer, when 18 ℃ of temperature, stirred 46 minutes.The concentrated probiotics prozyme raw material of 540kg (account for raw mix gross weight 18%) 23 ℃ of addings, was stirred relative humidity 37% 45 minutes.Add 60kg (account for raw mix gross weight 2%) ferment fruit juice, 28 ℃ of temperature stirred 30 minutes.Add 80kg (account for raw mix gross weight 2.67%) functional factor stachyose and 160kg (account for raw mix gross weight 5.33%) functional factor soybean oligosaccharide.Add then and add 510kg (account for raw mix gross weight 17%) concentrated probiotics prozyme raw material again, continue to stir 27 minutes, come out of the stove, cross 120 mesh sieves in 30 ℃ of temperature.
2. Secondary Fermentation:
Mixture after sieving is by stainless steel tank, enters cleanliness factor and be hundred grades sweathouse.Divide in fermentation box, each fermentation box is of a size of 50 * 30 * 20.The fermentation frame apart from ground high 1.5m, three layers, the layer apart from 0.5m, transverse distance 0.4m between fermentation box, 1.2m between frame and the frame, 37 ℃ of temperature, humidity 20-45%.
Fs (0-48 hour), manually fully stir 37 ℃ of temperature.Subordinate phase (the 48th hour the-the 68th hour), logical clean wind stirs, and per 8 hours are once, 30 ℃ of temperature.Phase III (the 68th hour the-the 72nd hour), static state, 22 ℃ of temperature.
3. can
Be packaged into pulvis respectively or be pressed into tablet.
Embodiment five
Raw material sources are identical with embodiment one.
1. the preparation of fermentation raw material:
Starch 320kg (account for raw mix gross weight 32.52%), glucose 210kg (account for raw mix gross weight 21.34%) are put into miniature stirrer, when 20 ℃ of temperature, stirred 40 minutes.The concentrated probiotics prozyme raw material of 170kg (account for raw mix gross weight 17.28%) 23 ℃ of addings, was stirred relative humidity 37% 35 minutes.Add 20.8kg (account for raw mix gross weight 2.11%) ferment fruit juice stirring and evenly mixing, 30 ℃ of temperature, 29 minutes time.Add 33.28kg (account for raw mix gross weight 3.38%) functional factor stachyose and 49.92 (account for raw mix gross weight 5.07%) functional factor galactosyl lactose.Add then and add 180kg (account for raw mix gross weight 18.29%) concentrated probiotics prozyme raw material again, continue to stir 30 ℃ of temperature 27 minutes.Come out of the stove, cross 100 mesh sieves.
2. Secondary Fermentation:
Mixture after sieving is by stainless steel tank, enters cleanliness factor and be hundred grades sweathouse.Divide in fermentation box, each fermentation box is of a size of 50 * 30 * 20.The fermentation frame apart from ground high 1.5m, three layers, the layer apart from 0.5m, transverse distance 0.4m between fermentation box, 1.2m between frame and the frame, 37 ℃ of temperature, humidity 20-45%.
Fs (0-48 hour), manually fully stir 37 ℃ of temperature.Subordinate phase (the 48th hour the-the 68th hour), logical clean wind stirs, and per 8 hours are once, 30 ℃ of temperature.Phase III (the 68th hour the-the 72nd hour), static state, 22 ℃ of temperature.
3. can
Can becomes capsule or is pressed into tablet.
Claims (8)
1. the production method of a probiotic composite enzyme is characterized in that described probiotic composite enzyme is is that raw material carries out Secondary Fermentation with spissated probiotic composite enzyme, the probiotic composite enzyme pulvis, tablet or the capsule that obtain.
2. according to the described production method of claim 1, it is characterized in that described probiotic composite enzyme raw material is rich in beneficial microbe colony and a large amount of lytic enzymes such as saccharifying enzyme, lipase and proteolytic enzyme such as aspergillus, yeast, lactobacillus and genus bacillus.
3. according to the described production method of claim 2, the production process that it is characterized in that described probiotic composite enzyme comprises the mixing of concentrated probiotics prozyme and auxiliary material, Secondary Fermentation and can.
4. according to the described production method of claim 3, it is characterized in that described auxiliary material comprises starch and the 20%-30% glucose of the 28%-38% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight.
5. according to the described production method of claim 4, it is characterized in that also adding the ferment fruit juice of the 1%-5% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight.
6. according to the described production method of claim 5, it is characterized in that also adding the functional factor of the 5%-10% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight.
7. according to the described production method of claim 6, it is characterized in that described functional factor comprises stachyose.
8. according to the described production method of claim 7, it is characterized in that described production process mixing for (one) concentrated probiotics prozyme raw material and auxiliary material, i. will account for the starch of 30%-35% of concentrated probiotics prozyme raw material and auxiliary material gross weight and the glucose of 22%-26%, in 18-20 ℃ of stirring and evenly mixing 40-50 minute, ii. the concentrated probiotics prozyme raw material that adds the 13%-18% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight, in temperature 22-26 ℃ stirring and evenly mixing 35-45 minute, relative humidity 34%-37%, iii. the ferment fruit juice that adds the 2%-4% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight, in temperature 25-30 ℃ stirring and evenly mixing 25-30 minute, iv. the functional factor stirring and evenly mixing that adds the 6%-8% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight, v. the concentrated probiotics prozyme raw material that adds the 13%-18% that accounts for concentrated probiotics prozyme raw material and auxiliary material gross weight, in temperature 25-35 ℃ stirring and evenly mixing 28-34 minute, form raw mix, sieve, (2) fermentation, it is hundred grades sweathouse that raw mix after sieving enters cleanliness factor, divide in fermentation box, fs, 0-48 hour, manually fully stir, temperature 35-40 ℃, subordinate phase, 48-68 hour, logical clean wind stirred, and per 8 hours once, temperature 27-35 ℃, phase III, 68-72 hour, static state, temperature 20-25 ℃, (three) can becomes pulvis, capsule or be pressed into tablet.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210642A (en) * | 2010-04-06 | 2011-10-12 | 保罗生物园科技股份有限公司 | Cleaning cosmetic composition and preparation method thereof |
| CN102210643A (en) * | 2010-04-06 | 2011-10-12 | 保罗生物园科技股份有限公司 | Anti-wrinkle cosmetic composition and preparation method thereof |
| CN102283796A (en) * | 2010-04-06 | 2011-12-21 | 保罗生物园科技股份有限公司 | Acne-removing cosmetic composition and preparation method thereof |
| CN101700253B (en) * | 2009-12-03 | 2012-04-18 | 内蒙古双奇药业股份有限公司 | Probiotic tablet and preparation method thereof |
| CN103053792A (en) * | 2013-01-09 | 2013-04-24 | 李晓叶 | Production process of composite probiotics |
-
2005
- 2005-09-16 CN CNB2005101031332A patent/CN100420743C/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700253B (en) * | 2009-12-03 | 2012-04-18 | 内蒙古双奇药业股份有限公司 | Probiotic tablet and preparation method thereof |
| CN102210642A (en) * | 2010-04-06 | 2011-10-12 | 保罗生物园科技股份有限公司 | Cleaning cosmetic composition and preparation method thereof |
| CN102210643A (en) * | 2010-04-06 | 2011-10-12 | 保罗生物园科技股份有限公司 | Anti-wrinkle cosmetic composition and preparation method thereof |
| CN102283796A (en) * | 2010-04-06 | 2011-12-21 | 保罗生物园科技股份有限公司 | Acne-removing cosmetic composition and preparation method thereof |
| CN103053792A (en) * | 2013-01-09 | 2013-04-24 | 李晓叶 | Production process of composite probiotics |
| CN103053792B (en) * | 2013-01-09 | 2014-02-12 | 李晓叶 | Production process of composite probiotics |
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| CN100420743C (en) | 2008-09-24 |
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Assignee: Polo Biological Garden Technology Co.,Ltd. Assignor: Beijing Sino Paul Biological Technology Co.,Ltd. Contract record no.: 2010110000212 Denomination of invention: Probiotic composite enzyme production method Granted publication date: 20080924 License type: Exclusive License Open date: 20060503 Record date: 20101209 |