CN1739650A - Cappillary artemisia-cape jasmine-rhubarb soft capsule and its prepn process - Google Patents
Cappillary artemisia-cape jasmine-rhubarb soft capsule and its prepn process Download PDFInfo
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Abstract
The present invention relates to new preparation form of capillary artemisia-cape jasmine-rhubarb medicine, and is especially one kind of capillary artemisia-cape jasmine-rhubarb soft capsule and its preparation process. The capillary artemisia-cape jasmine-rhubarb soft capsule consists of medicine liquid oil and covering, and the medicine liquid oil consists of capillary artemisia-cape jasmine-rhubarb extract, diluent, suspension assistant and wetter. Compared with available capillary artemisia-cape jasmine-rhubarb oral liquid, the capillary artemisia-cape jasmine-rhubarb soft capsule has the advantages of high stability, high bioavailability and high curative effect. In addition, the present invention has high flowability, high dispersion, accurate amount and other features.
Description
Technical field
Invention relates to the yellow new pharmaceutical preparation of mattress Cape jasmine, is specifically related to Yinzhi huang capsule and preparation technology thereof.
Background technology
Mattress Cape jasmine Huang derives from Herba Artemisiae Scopariae Decoction in the treatise on Febrile Diseases, and YINZHIHUANG ZHIJI is to be purified and formed by Herba Artemisiae Scopariae, Fructus Gardeniae, baicalin, Flos Lonicerae.Herba Artemisiae Scopariae has clearing away heat-damp and promoting diuresis, the effect of detoxifcation jaundice eliminating; Fructus Gardeniae clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body have the glutamate pyruvate transaminase of reduction and glutamic oxaloacetic transaminase, GOT effect; Baicalin heat-clearing and toxic substances removing, pathogenic fire purging, blood circulation promoting and blood stasis dispelling, the effect of detoxifcation, light a surname evacuation.Modern pharmacology studies show that: mattress Cape jasmine Huang has and protects the liver, function of gallbladder promoting, falls effects such as detoxifcation of enzyme, jaundice eliminating and antiviral, and the effect that promotes the Turnover of Mouse Peritoneal Macrophages phagocytic function is all arranged, and is mainly used in the acute and chronic viral hepatitis of treatment clinically.
The oral formulations of mattress Cape jasmine Huang mainly is a Yinzhihuang oral liquid in the market, Yinzhihuang oral liquid extracts for the plurality of Chinese component and makes, its complicated component, the instability that is subject to the extraneous factor influence and becomes, thereby affect the treatment, if but developed other oral solid formulation, as tablet or granule, its bioavailability of medicament would reduce again greatly.
Therefore, develop a kind of oral liquid bioavailability that neither reduces and simultaneously can solve its stable novel formulation again and be very important, and the Yinzhi huang capsule novel formulation has just in time overcome above-mentioned technological deficiency.
But, those of ordinary skills know, Chinese medicinal soft capsule is different with the Western medicine soft capsule, Western medicine soft capsule content composition is more single to be easy to make oil solution, and than being easier to capsuleization, and the prescription of Chinese medicine is very complicated, paste-forming rate is big, water absorption is strong, and the content preparation is comparatively complicated, and this just objectively requires soft capsule content not only to want uniform and stable but also will have good flowability.Therefore, preparation good effect, bioavailability height, stay-in-grade soft capsule, its technical difficulty is very big, be not those of ordinary skills adopt routine techniques can do and obtain.
Summary of the invention
The present invention is directed to above technological deficiency, a kind of new Yinzhi huang capsule and preparation technology thereof are provided.
Yinzhi huang capsule of the present invention is made up of medicinal liquid oil and capsule material, and its herb liquid oil is made up of the yellow extract of mattress Cape jasmine, diluent, suspending agent and wetting agent;
Because the complexity of Chinese medicine ingredients, technological deficiencies such as the content character is inhomogeneous, easy layering often appear in Chinese medicinal soft capsule, thereby cause loading amount inaccurate, the therapeutic effect that does not reach, and suitable adjuvant can make soft capsule content have good stable and flowability, have good suspendible effect simultaneously, therefore select suitable adjuvant to seem extremely important.
The present inventor finds by experimental study, and Yinzhi huang capsule medicinal liquid oil of the present invention should be made up of the diluent of the yellow extract of the mattress Cape jasmine of 1 weight fraction, 1.0-2.0 weight portion, the wetting agent that accounts for the suspending agent of diluent weight 1-4% and account for the 1-4% of diluent weight; More preferably form by the diluent of the yellow extract of the mattress Cape jasmine of 1 weight fraction, 1.20-1.60 weight portion, the wetting agent that accounts for the suspending agent of diluent weight 2-3% and account for diluent weight 2-3%.
Diluent among the present invention in the Yinzhi huang capsule can be selected the various diluent of this area routine for use, but should be prerequisite with discord active component generation chemical reaction of the present invention, diluent be preferably one or more the vegetable oil in Oleum Sesami, Oleum Arachidis hypogaeae semen, Semen Maydis oil, soybean oil, almond oil, walnut oil, Oleum Gossypii semen, Oleum Helianthi, Oleum Ricini and the olive oil among the present invention; Further be preferably one or more vegetable oil in Oleum Arachidis hypogaeae semen, Semen Maydis oil, the soybean oil; Wetting agent wherein is soil temperature class or spans; Be preferably Arlacel-80.
Not only the medicinal liquid oil quality directly influences soft capsule quality in Chinese medicinal soft capsule, the quality of capsule shells also directly determines the quality of soft gelatin pharmaceutical itself, it is having a strong impact on the disintegrate and the intravital bioavailability of Chinese medicinal soft capsule, therefore, it is particularly crucial that the prescription of capsule material seems, the capsule material of Yinzhi huang capsule of the present invention is the sizing material by 1 weight fraction, 0.5 the distilled water of the plasticizer of weight portion and 1 weight portion and an amount of opacifier, wherein sizing material is gelatin or arabic gum among the present invention, gelatin more preferably, the power value of freezing of gelatin should be greater than 180g among the present invention, moisture should be between 40%～50%, and the viscosity of glue should be controlled at 2700～3000mPa.s; Plasticizer is glycerol or sorbitol or both combination, more preferably glycerol; Opacifier of the present invention can be selected the opacifier of this area routine such as curcumin, milk chocolate palm fibre, ferrum oxide etc. for use, is preferably the milk chocolate palm fibre.
In the Yinzhi huang capsule of the present invention, the yellow extract of mattress Cape jasmine is made up of Herba Artemisiae Scopariae extract, 21.33 weight portion Fructus Gardeniae extracts, the baicalin of 133.33 weight portions and the Flos Lonicerae extract of 26.67 weight portions of 40 weight portions.
The yellow extract of mattress Cape jasmine of the present invention can adopt the technology of this area routine to be prepared, but the moisture in the yellow extract of the mattress Cape jasmine of its preparation exceeds to be no more than 3% (weight), and wherein the yield of Herba Artemisiae Scopariae extract should be more than 7% (percentage by weight); The yield of Flos Lonicerae extract should be more than 10% (percentage by weight); The yield of Fructus Gardeniae extract should be more than 8% (percentage by weight), and jasminoidin purity is more than 8% (percentage by weight); The baicalin yield should be more than 10% (percentage by weight), and baicalin purity is more than 90%.
Wherein, the moisture of the yellow extract of mattress Cape jasmine and the detection of yield in each extract and purity can adopt the detection method of various this areas routine to detect.
The yellow extract of mattress Cape jasmine of the present invention preferably adopts following method to make: get Herba Artemisiae Scopariae, decoct with water three times, add 10 times of water gagings at every turn, decocted 1.5 hours for the first time, second, respectively decocted for three times 1 hour, collecting decoction filters, and filtrate is concentrated into every 1ml and contains crude drug 2g (80 ℃ of surveys, proportion 1.12～1.15), add ethanol and make and contain alcohol amount and reach 70%, cold preservation 24 hours filters, filtrate recycling ethanol extremely every ml contains crude drug 5g (80 ℃ of surveys, proportion 1.17～1.20), adding ethanol again makes and contains alcohol amount and reach 85%, cold preservation 24 hours, filter, filtrate recycling ethanol extremely every ml contains crude drug 10g (80 ℃ of surveys, proportion 1.18～1.22), adds the about 5 times of amounts of water, cold preservation 48 hours, filter, filtrate is condensed into the thick paste shape, and vacuum drying promptly.
Get Fructus Gardeniae, be ground into coarse powder, decoct with water three times, add 8 times of water gagings, first at every turn, secondary respectively decocted 1 hour, decocted for the third time 0.5 hour, collecting decoction filters, and filtrate is concentrated into every 1ml and contains crude drug 1g (80 ℃ of surveys, proportion 1.10～1.13), adding ethanol makes and contains alcohol amount and reach 70%, cold preservation 24 hours, filter, filtrate recycling ethanol extremely every ml contains crude drug 3g (80 ℃ of surveys, proportion 1.17～1.20), add ethanol and make and contain alcohol amount and reach 85%, cold preservation 24 hours filters, filtrate recycling ethanol extremely every ml contains crude drug 5g (80 ℃ of surveys, proportion 1.20～1.23), add the about 5 times of amounts of water, cold preservation 48 hours, filter, filtrate is condensed into the thick paste shape, vacuum drying promptly, this product contains jasminoidin (C
17H
24O
10), should be less than 8.0%.
Get Radix Scutellariae, be ground into coarse powder, decoct with water three times, add 8 times of water gagings at every turn, decocted 1 hour, collecting decoction filters, and filtrate is heated to 80 ℃, add hydrochloric acid and regulate pH1～2, leave standstill, filter, precipitate adds 2 times of water gagings and stirs into pasty state, add 40% sodium hydroxide and regulate pH to 6.5～7, filter, filtrate adds equivalent ethanol, is heated to 80 ℃, add hydrochloric acid and regulate pH to 1～2, baicalin is separated out, filter, use washing with alcohol, drying promptly gets this product and contains baicalin C
21H
18O
11Must not be less than 90.0%.
Extracting honeysuckle decocts with water secondary, adds 10 times of water gagings at every turn, decocts 1 hour, collecting decoction filters, and filtrate is concentrated into and contains crude drug 2g (70 ℃ of surveys among every 1ml, proportion 1.18～1.21), be chilled to 45-60 ℃, add the 20-40% aqua calcis and regulate pH value to 12, filter, precipitate adds 2 times of amount ethanol, leaves standstill, regulate pH value to 3.0-4.0 with 50% sulphuric acid, filter, filtrate is regulated pH value to 6.5-7.0 with 40% sodium hydroxide solution, reclaim ethanol, concentrate thick paste, vacuum drying is promptly.
Preparation of soft capsule technology of the present invention can adopt this area routine techniques to be prepared, but in order to reach better technique effect, preferably adopts following prepared: the yellow extract of mattress Cape jasmine is pulverized, and 100 orders sieve, and are standby; Get suspending agent, wetting agent,, join in the diluent stirring and evenly mixing in 60 ℃ of heating in water bath fusings; Then the yellow extract fine powder of mattress Cape jasmine is added in the diluent, stirring and evenly mixing is milled with the colloid mill circulation then, and particle diameter remains between the 70-90 μ m, abundant mixing, and Guo Mu Sieve makes soft capsule content; Get sizing material, plasticizer, distilled water, opacifier and after changing glue, make rubber, carry out the embedding pelleting then, make soft capsule.
The yellow extract of mattress Cape jasmine that adopts the yellow extract preparation technology of mattress Cape jasmine of the present invention to make keeps the active component in the crude drug to the full extent, stable and the lighter color of extract yield, the character homogeneous, water content is controlled at below 2.5%, overcome the long high temperature heat drying of clear paste in the traditional handicraft and problems such as complexion changed and ingredient heat loss have taken place, shortened man-hour, improved work efficiency, reduce germ contamination, quick, easy.
Simultaneously, Yinzhi huang capsule of the present invention is compared to have with the prior art oral liquid and is stablized, the bioavailability height, therapeutic effect is good, and similar technology soft capsule technology with other is compared, medicinal liquid have better stability and mobile, be uniformly dispersed, install accurately, appearance looks elegant, characteristics such as disintegration rate is fast, bioavailability is higher.
The specific embodiment
The present invention further sets forth the present invention by following examples and test example, but is not limited to this.
Embodiment 1
The preparation of the yellow extract of mattress Cape jasmine
The preparation of Herba Artemisiae Scopariae extract: get Herba Artemisiae Scopariae 1kg, decoct with water three times, add 10 times of water gagings at every turn, for the first time decocted second 1.5 hours, respectively decocted collecting decoction for three times 1 hour, filter, filtrate is concentrated into every 1ml and contains crude drug 2g (80 ℃ of surveys, proportion 1.12～1.15), adds ethanol and makes and contain alcohol amount and reach 70%, cold preservation 24 hours, filter, filtrate recycling ethanol extremely every ml contains crude drug 5g (80 ℃ of surveys, proportion 1.17～1.20), adding ethanol again makes and contains alcohol amount and reach 85%, cold preservation 24 hours filters, and filtrate recycling ethanol extremely every ml contains crude drug 10g (80 ℃ of surveys, proportion 1.18～1.22), add the about 5 times of amounts of water, cold preservation 48 hours filters, filtrate is condensed into the thick paste shape, vacuum drying (0.06～-0.08Mpa, 80～85 ℃), promptly.
The preparation of Fructus Gardeniae extract: get Fructus Gardeniae 1kg, be ground into coarse powder, decoct with water three times, add 8 times of water gagings, first at every turn, secondary respectively decocted 1 hour, decocted for the third time 0.5 hour, collecting decoction filters, and filtrate is concentrated into every 1ml and contains crude drug 1g (80 ℃ of surveys, proportion 1.10～1.13), add ethanol and make and contain alcohol amount and reach 70%, cold preservation 24 hours filters, filtrate recycling ethanol extremely every ml contains crude drug 3g (80 ℃ of surveys, proportion 1.17～1.20), adding ethanol makes and contains alcohol amount and reach 85%, cold preservation 24 hours, filter, filtrate recycling ethanol extremely every ml contains crude drug 5g (80 ℃ of surveys, proportion 1.20～1.23), adds the about 5 times of amounts of water, cold preservation 48 hours, filter, filtrate is condensed into the thick paste shape, vacuum drying (0.06～-0.08Mpa, 80～85 ℃), promptly.
The preparation of baicalin: get Radix Scutellariae 1kg, be ground into coarse powder, decoct with water three times, add 8 times of water gagings at every turn, decocted 1 hour, collecting decoction filters, and filtrate is heated to 80 ℃, add hydrochloric acid and regulate pH1～2, leave standstill, filter, precipitate adds 2 times of water gagings and stirs into pasty state, add 40% sodium hydroxide and regulate pH to 6.5～7, filter, filtrate adds equivalent ethanol, is heated to 80 ℃, add hydrochloric acid and regulate pH to 1～2, baicalin is separated out, filter, use washing with alcohol, drying, promptly.This product contains baicalin C
21H
18O
11Must not be less than 90.0%.
The preparation of Flos Lonicerae: extracting honeysuckle 1kg, decoct with water secondary, add 10 times of water gagings at every turn, decocted 1 hour, collecting decoction filters, and filtrate is concentrated into and contains crude drug 2g (70 ℃ of surveys among every 1ml, proportion 1.18～1.21), be chilled to 45-60 ℃, add the 20-40% aqua calcis and regulate pH value to 12, filter, precipitate adds 2 times of amount ethanol, leave standstill, regulate pH value to 3.0-4.0, filter with 50% sulphuric acid, filtrate is regulated pH value to 6.5-7.0 with 40% sodium hydroxide solution, reclaim ethanol, concentrate thick paste, vacuum drying (0.06～-0.08Mpa, 80～85 ℃), get Flos Lonicerae extract.
The preparation of Yinzhi huang capsule
Embodiment 2
Prescription: Herba Artemisiae Scopariae extract 40g, Fructus Gardeniae extract 21.33g, baicalin 133.33g, Flos Lonicerae extract 26.67g; Soybean salad oil 350g, Cera Flava 7.3g, Arlacel-80 7.3g, gelatin 200g, glycerol 100g, water 200ml, milk chocolate palm fibre 0.6g,
Preparation technology: get the yellow extract of mattress Cape jasmine, pulverize, cross 100 mesh sieves, standby; Get recipe quantity Cera Flava, Arlacel-80,, add in the soybean salad oil stirring and evenly mixing in 60 ℃ of heating in water bath fusings; Said extracted thing fine powder is added in the fluid, and stirring and evenly mixing is regulated the colloid mill fineness between 5～15 μ m, adds the medicinal liquid circulation and mills 0.5 hour, and fully mixing filters, and makes soft capsule content; Get gelatin, glycerol, distilled water, milk chocolate palm fibre, make rubber after changing glue, the embedding pelleting is made 1000 of soft capsules, and dry 12 hours, ethanol was washed ball, drying, chosen ball, promptly.
Embodiment 3
Prescription: Herba Artemisiae Scopariae extract 40g, Fructus Gardeniae extract 21.33g, baicalin 133.33g, Flos Lonicerae extract 26.67g; Oleum Arachidis hypogaeae semen 380g, Cera Flava 10g, Arlacel-80 10g, gelatin 200g, glycerol 100g, water 200ml, milk chocolate palm fibre 0.6g,
Preparation technology: get the yellow extract of mattress Cape jasmine, pulverize, cross 100 mesh sieves, standby; Get recipe quantity Cera Flava, Arlacel-80,, add in the Oleum Arachidis hypogaeae semen stirring and evenly mixing in 60 ℃ of heating in water bath fusings; Said extracted thing fine powder is added in the fluid, and stirring and evenly mixing is regulated the colloid mill fineness between 5～15 μ m, adds the medicinal liquid circulation and mills 0.5 hour, and fully mixing filters (crossing 100 Mu Sieve), makes soft capsule content; Get gelatin, glycerol, distilled water, milk chocolate palm fibre, after changing glue, make rubber, the embedding pelleting, dry 12 hours, ethanol was washed ball, drying, is chosen ball, promptly.
The preparation of embodiment 4 Yinzhi huang capsules
Prescription: Herba Artemisiae Scopariae extract 40g, Fructus Gardeniae extract 21.33g, baicalin 133.33g, Flos Lonicerae extract 26.67g; Semen Maydis oil 280g, Cera Flava 5.5g, Arlacel-80 5.5g, water 200ml, glycerol 100g, gelatin 200g, milk chocolate palm fibre 0.6g,
Preparation technology: get the yellow extract of mattress Cape jasmine, pulverize, cross 100 mesh sieves, standby; Get recipe quantity Cera Flava, Arlacel-80,, add in the Semen Maydis oil oil stirring and evenly mixing in 60 ℃ of heating in water bath fusings; Said extracted thing fine powder is added in the fluid, and stirring and evenly mixing is regulated the colloid mill fineness between 5～15 μ m, adds the medicinal liquid circulation and mills 0.5 hour, and fully mixing filters (crossing 100 Mu Sieve), makes soft capsule content;
Get gelatin, glycerol, distilled water, milk chocolate palm fibre, make rubber after changing glue, the embedding pelleting is made 1000 of soft capsules, and dry 12 hours, ethanol was washed ball, drying, chosen ball, promptly.
Embodiment 5
Prescription: Herba Artemisiae Scopariae extract 40g, Fructus Gardeniae extract 21.33g, baicalin 133.33g, Flos Lonicerae extract 26.67g; Soybean salad oil 350g, aluminum monostearate 7.3g, soil temperature-807.3g, water 200ml, glycerol 100g, gelatin 200g, milk chocolate palm fibre 0.6g,
Preparation technology: get the yellow extract of mattress Cape jasmine, pulverize, cross 100 mesh sieves, standby; Get the recipe quantity aluminum monostearate, soil temperature-80 melts in 60 ℃ of heating in water bath, adds in the soybean salad oil stirring and evenly mixing; Said extracted thing fine powder is added in the fluid, and stirring and evenly mixing is regulated the colloid mill fineness between 5～15 μ m, adds the medicinal liquid circulation and mills 0.5 hour, and fully mixing filters (crossing 100 Mu Sieve), makes soft capsule content;
Get gelatin, glycerol, distilled water, milk chocolate palm fibre, after changing glue, make rubber, the embedding pelleting, dry 12 hours, ethanol was washed ball, drying, is chosen ball, promptly.
Embodiment 6
Prescription: Herba Artemisiae Scopariae extract 40g, Fructus Gardeniae extract 21.33g, baicalin 133.33g, Flos Lonicerae extract 26.67g; Soybean salad oil 350g, Cera Flava 7.3g, Arlacel-80 7.3g, water 200ml, sorbitol 100g, arabic gum 200g, milk chocolate palm fibre 0.6g,
Preparation technology: get the yellow extract of mattress Cape jasmine, pulverize, cross 100 mesh sieves, standby; Get recipe quantity Cera Flava, Arlacel-80,, add in the soybean salad oil stirring and evenly mixing in 60 ℃ of heating in water bath fusings; Said extracted thing fine powder is added in the fluid, and stirring and evenly mixing is regulated the colloid mill fineness between 5～15 μ m, adds the medicinal liquid circulation and mills 0.5 hour, and fully mixing filters (crossing 100 Mu Sieve), makes soft capsule content;
Get arabic gum, sorbitol, distilled water, milk chocolate palm fibre, after changing glue, make rubber, the embedding pelleting, dry 12 hours, ethanol was washed ball, drying, is chosen ball, promptly.
Test example 1 Yinzhi huang capsule study on the stability
Investigation method: get this product (embodiment of the invention 1 and 2 preparations, the plastic-aluminum bubble-cap, 12/plate, 0.6g/ grain) place under the room temperature condition respectively and constant temperature and humidity (37 ℃ of temperature, humidity 75%) preserve under the condition, of that month examination was once examined once in later every month, three totally months, examination once (2004.1～2004.7) again in six months.
The investigation project: the stability test of " soft capsule " requires content, and the examination project of this product is decided to be five of character, discriminating, disintegration, assay, limit test of microbe etc.
Conclusion: from investigating result " Yinzhi huang capsule " frequent 0～6 month preliminarily stabilised investigation of relaxing the bowels with purgatives of warm nature and constant temperature and humidity (37 ℃ of temperature as can be seen, humidity 75%) 0～6 month accelerated stability is investigated under the condition, every index was compared there was no significant difference with 0 month, all meet preparation quality standard (draft) regulation, show this product steady quality, preparation technology's rationally feasible (specifically seeing Table 1 table 2).
Table 1 preparation preliminarily stabilised investigation report
Sample title: Yinzhi huang capsule lot number 040105
Table 4 preparation accelerated stability investigation report
(constant temperature and humidity: 37 ℃ of temperature, humidity 75%)
Sample title: Yinzhi huang capsule lot number 040105
Claims (11)
1, a kind of Yinzhi huang capsule is characterized in that being made up of medicinal liquid oil and capsule material, and its herb liquid oil is made up of the yellow extract of mattress Cape jasmine, diluent, suspending agent and wetting agent.
2, according to the Yinzhi huang capsule of claim 1, it is characterized in that being made up of medicinal liquid oil and capsule material, its herb liquid oil is made up of the diluent of the mattress Cape jasmine Huang extract of 1 weight portion, 1.0-2.0 weight portion, the wetting agent that accounts for the suspending agent of diluent weight 1-4% and account for diluent weight 1-4%.
3, Yinzhi huang capsule according to claim 2, it is characterized in that being made up of medicinal liquid oil and capsule material, its herb liquid oil is made up of the diluent of the mattress Cape jasmine Huang extract of 1 weight portion, 1.2-1.6 weight portion, the wetting agent that accounts for the suspending agent of diluent weight 2-3% and account for diluent weight 2-3%.
4,, it is characterized in that diluent is one or more the vegetable oil in Oleum Sesami, Oleum Arachidis hypogaeae semen, Semen Maydis oil, soybean oil, almond oil, walnut oil, Oleum Gossypii semen, Oleum Helianthi, Oleum Ricini and the olive oil according to the described Yinzhi huang capsule of claim 1-3; Suspending agent is one or more in Cera Flava, aluminum monostearate, the ethyl cellulose (100CP); Wetting agent is Tweens or spans.
5, Yinzhi huang capsule according to claim 4 is characterized in that diluent is one or more vegetable oil in Oleum Arachidis hypogaeae semen, Semen Maydis oil, the soybean oil; Suspending agent is a Cera Flava; Wetting agent is the sorbester p17 class.
6,, it is characterized in that the capsule material is by the sizing material of 1 weight fraction, plasticizer and the distilled water of 1 weight portion and an amount of opacifier of 0.5 weight portion according to the described Yinzhi huang capsule of claim 1-3.
7, Yinzhi huang capsule according to claim 6 is characterized in that sizing material is gelatin or arabic gum; Plasticizer is glycerol or sorbitol or both combinations; Opacifier is the milk chocolate palm fibre.
8,, it is characterized by the yellow extract of mattress Cape jasmine and form by Herba Artemisiae Scopariae extract, 21.33 weight portion Fructus Gardeniae extracts, the baicalin of 133.33 weight portions and the Flos Lonicerae extract of 26.67 weight portions of 40 weight portions according to the described Yinzhi huang capsule of claim 1-3.
9, Yinzhi huang capsule according to claim 8 is characterized in that the moisture of the yellow extract of mattress Cape jasmine should not surpass 3% (w/w), and wherein the yield of Herba Artemisiae Scopariae extract should be more than 7% (w/w); The yield of Flos Lonicerae extract should be more than 10% (w/w); The yield of Fructus Gardeniae extract should be more than 8% (w/w), and jasminoidin purity is more than 8%; The baicalin yield should be more than 10% (w/w), and baicalin purity is more than 90%.
10, Yinzhi huang capsule according to claim 9 is characterized in that the yellow extract of mattress Cape jasmine adopts following method to make: get Herba Artemisiae Scopariae, decoct with water three times, add 10 times of water gagings at every turn, decocted second 1.5 hours for the first time, respectively decocted for three times 1 hour, collecting decoction filters, and filtrate is concentrated into every 1ml and contains crude drug 2g (80 ℃ of surveys, proportion 1.12～1.15), add ethanol and make and contain alcohol amount and reach 70%, cold preservation 24 hours filters, filtrate recycling ethanol extremely every ml contains crude drug 5g (80 ℃ of surveys, proportion 1.17～1.20), adding ethanol again makes and contains alcohol amount and reach 85%, cold preservation 24 hours, filter, filtrate recycling ethanol extremely every ml contains crude drug 10g (80 ℃ of surveys, proportion 1.18～1.22), adds the about 5 times of amounts of water, cold preservation 48 hours, filter, filtrate is condensed into the thick paste shape, vacuum drying (0.06～-0.08Mpa, 80～85 ℃), promptly;
Get Fructus Gardeniae, be ground into coarse powder, decoct with water three times, add 8 times of water gagings, first at every turn, secondary respectively decocted 1 hour, decocted for the third time 0.5 hour, collecting decoction filters, and filtrate is concentrated into every 1ml and contains crude drug 1g (80 ℃ of surveys, proportion 1.10～1.13), add ethanol and make and contain alcohol amount and reach 70%, cold preservation 24 hours filters, filtrate recycling ethanol extremely every 1ml contains crude drug 3g (80 ℃ of surveys, proportion 1.17～1.20), adding ethanol makes and contains alcohol amount and reach 85%, cold preservation 24 hours, filter, filtrate recycling ethanol extremely every ml contains crude drug 5g (80 ℃ of surveys, proportion 1.20～1.23), adds the about 5 times of amounts of water, cold preservation 48 hours, filter, filtrate is condensed into the thick paste shape, vacuum drying (0.06～-0.08Mpa, 80～85 ℃), promptly;
Get Radix Scutellariae, be ground into coarse powder, decoct with water three times, add 8 times of water gagings at every turn, decocted 1 hour, collecting decoction filters, and filtrate is heated to 80 ℃, add hydrochloric acid and regulate pH1～2, leave standstill, filter, precipitate adds 2 times of water gagings and stirs into pasty state, add 40% sodium hydroxide and regulate pH to 6.5～7.0, filter, filtrate adds equivalent ethanol, is heated to 80 ℃, add hydrochloric acid and regulate pH to 1.0～2.0, baicalin is separated out, filter, use washing with alcohol, drying, promptly;
Extracting honeysuckle decocts with water secondary, adds 10 times of water gagings at every turn, decocted 1 hour, collecting decoction filters, and filtrate is concentrated into and contains crude drug 2g (70 ℃ of surveys among every 1ml, proportion 1.18～1.21), be chilled to 45-60 ℃, add the 20-40% aqua calcis and regulate pH value to 12, filter, precipitate adds 2 times of amount ethanol, leave standstill, regulate pH value to 3.0-4.0, filter with 50% sulphuric acid, filtrate is regulated pH value to 6.5-7.0 with 40% sodium hydroxide solution, reclaim ethanol, concentrate thick paste, vacuum drying (0.06～-0.08Mpa, 80～85 ℃), get Flos Lonicerae extract.
11, the preparation technology of the described Yinzhi huang capsule of a kind of claim 1-3 is characterized by: the yellow extract of mattress Cape jasmine is pulverized, and 100 orders sieve, and are standby; Get suspending agent, wetting agent,, join in the diluent stirring and evenly mixing in 60 ℃ of heating in water bath fusings; Then the yellow extract fine powder of mattress Cape jasmine is added in the diluent, stirring and evenly mixing is milled with the colloid mill circulation then, and particle diameter remains between the 70-90 μ m, and fully mixing is crossed mesh sieve, makes soft capsule content; Get sizing material, plasticizer, distilled water, opacifier and after changing glue, make rubber, carry out the embedding pelleting then, make soft capsule.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100568374A CN100356946C (en) | 2004-08-24 | 2004-08-24 | Cappillary artemisia-cape jasmine-rhubarb soft capsule and its prepn process |
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|---|---|---|---|
| CNB2004100568374A CN100356946C (en) | 2004-08-24 | 2004-08-24 | Cappillary artemisia-cape jasmine-rhubarb soft capsule and its prepn process |
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| Publication Number | Publication Date |
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| CN1739650A true CN1739650A (en) | 2006-03-01 |
| CN100356946C CN100356946C (en) | 2007-12-26 |
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| CNB2004100568374A Active CN100356946C (en) | 2004-08-24 | 2004-08-24 | Cappillary artemisia-cape jasmine-rhubarb soft capsule and its prepn process |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002849B (en) * | 2007-01-30 | 2011-01-26 | 中国人民解放军第三○二医院 | Traditional Chinese medicine extractive or tablet for treating hepatitis, and its preparing method |
| CN101204447B (en) * | 2007-12-19 | 2011-08-24 | 姚俊华 | Anti-hepatitis-jaundice soft capsule and preparation method thereof |
| CN101204446B (en) * | 2007-12-19 | 2011-08-24 | 姚俊华 | Soft capsule containing medicine for acute and chronic hepatitis |
| CN101199631B (en) * | 2007-12-19 | 2011-11-30 | 姚俊华 | Soft capsule containing micropowder silicagel and preparing method |
| CN101204445B (en) * | 2007-12-19 | 2012-09-12 | 姚俊华 | Soft capsule for hepatitis and preparation method thereof |
| CN105902652A (en) * | 2016-06-23 | 2016-08-31 | 合肥华方医药科技有限公司 | Orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and preparation method thereof |
| CN106236889A (en) * | 2016-08-29 | 2016-12-21 | 凯里市新元药店 | A kind of treat hot-tempered Chinese medicine formula |
-
2004
- 2004-08-24 CN CNB2004100568374A patent/CN100356946C/en active Active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101002849B (en) * | 2007-01-30 | 2011-01-26 | 中国人民解放军第三○二医院 | Traditional Chinese medicine extractive or tablet for treating hepatitis, and its preparing method |
| CN101204447B (en) * | 2007-12-19 | 2011-08-24 | 姚俊华 | Anti-hepatitis-jaundice soft capsule and preparation method thereof |
| CN101204446B (en) * | 2007-12-19 | 2011-08-24 | 姚俊华 | Soft capsule containing medicine for acute and chronic hepatitis |
| CN101199631B (en) * | 2007-12-19 | 2011-11-30 | 姚俊华 | Soft capsule containing micropowder silicagel and preparing method |
| CN101204445B (en) * | 2007-12-19 | 2012-09-12 | 姚俊华 | Soft capsule for hepatitis and preparation method thereof |
| CN105902652A (en) * | 2016-06-23 | 2016-08-31 | 合肥华方医药科技有限公司 | Orally taken lyophilized powder containing capillary artemisia, cape jasmine and scutellaria baicalensis and preparation method thereof |
| CN106236889A (en) * | 2016-08-29 | 2016-12-21 | 凯里市新元药店 | A kind of treat hot-tempered Chinese medicine formula |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100356946C (en) | 2007-12-26 |
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