CN1723778A - Silver-contg. type antibiotic agent, prepn. method and application thereof - Google Patents
Silver-contg. type antibiotic agent, prepn. method and application thereof Download PDFInfo
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- CN1723778A CN1723778A CN 200410069799 CN200410069799A CN1723778A CN 1723778 A CN1723778 A CN 1723778A CN 200410069799 CN200410069799 CN 200410069799 CN 200410069799 A CN200410069799 A CN 200410069799A CN 1723778 A CN1723778 A CN 1723778A
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Abstract
An Ag-contained antibacterial material used for preparing sterilizer, medical antibacterial materials and other antibacterial products is composed of the chitin and/or its derivatives as matrix and Ag-contained compound attached to said matrix.
Description
Technical field
The present invention relates to a kind of anti-biotic material and preparation method thereof and application, particularly about a kind of silver-containing antibacterial material and preparation method thereof and application.
Background technology
Antibiotic is the important medicine of a class on the clinical medicine.But antibiotic abuse also can produce serious adverse consequences, and especially bacterial drug resistance and drug-fast bacteria infection have become the difficult problem in the clinical treatment.So people strive to find better antibacterials and material.Silver is used existing very long history as anti-biotic material, and its advantage is: broad-spectrum antiseptic, have no drug resistance, safety, antibacterial efficacy are lasting etc.Silver is applied to a lot of fields in the prior art, as bactericide, antiseptic dressing, purifier, ceramics etc.
The sterilization mechanism of silver is, silver and sulfydryl in the pathogenic bacteria metabolic enzyme combine, and make enzyme deactivation, not energy metabolism and death of pathogenic bacteria; The peptide glycan reaction that exposes on silver and the bacteria cell wall forms the invertibity compound, makes it not advance cell to oxygen transport, stops the germ activity, causes its death; DNA base combination in silver and the pathogenic bacteria, silver ion forms cross-linked each other, causes the dna structure sex change, suppresses it and duplicates, and makes the pathogenic bacteria inactivation; Oxygen effect in silver and the water and air can produce reactive oxygen species, and these materials can destroy intracellular various important biomolecule macromolecule and film, also can form other activating oxide, destroys growth and the breeding of bacterium.
Along with the further investigation of people to silver-colored anti-microbial property, discovery is with the silver salt of solubility during as anti-biotic material, easily decompose the appearance color that makes product etc. changes owing to its character is unstable, thereby limited the scope of its application, so people have carried out research and the application as anti-biotic material of the oxide that utilizes argent or silver and peroxide.Chinese patent 92109288.1 discloses a kind of long-acting broad-spectrum antiseptic fabric and preparation method thereof, and this method is silver nitrate to be dissolved in the ammoniacal liquor obtain (Ag (NH
3)
2)
+, again with reductant with (Ag (NH
3)
2)
+Being reduced into simple substance silver is fixed on the fabric.Chinese patent 99111155.9, Chinese patent 01129506.6 and Chinese patent 02117479.2 are disclosed all to be silver nitrate to be dissolved in the ammoniacal liquor obtain (Ag (NH
3)
2)
+, again with reductant with (Ag (NH
3)
2)
+Be reduced into simple substance silver and be fixed on the fabric, then with oxidant further with the oxidation of argentiferous fabric to obtain the silver-containing antibacterial fabric.U.S. Pat 6436420B1 is disclosed be with silver peroxide by reactive deposition on fabric.Though above technology has solved discoloration problem, production technology is all complicated, and brings more impurity into.
Chitin and derivative thereof all are natural polymers, and be biodegradable again, and safety non-toxic has excellent biological compatibility and chemical property stable, is widely used in industries such as chemical industry, environmental protection, food, cosmetics, weaving, medicine, papermaking and agricultural.People are by discovering, chitin and derivative thereof have significant bacteriostasis.
For the anti-infectious function of chitin and derivative thereof, its mechanism mainly contains following several explanation: (1) stimulates body to promote the increase of PEC, and activating macrophage, thereby the generation of increase active oxygen are again by peroxidizing property sterilization mechanism generation effect; (2) to the direct activation of macrophage and increase the killing activity of macrophage; (3) activate the T lymphocyte and show killing activity, and can bring out delayed type hypersensitivity, DTH by sensitized T cell; (4) activate the T lymphocyte MAF is discharged, and then activating macrophage, and make F
3, C
3Acceptor obtains expressing and lysosomal generation.
The use in conjunction of silver and chitin and derivative thereof also has report in the prior art, and BP GB19990003842 is disclosed to be the chitin derivativ shitosan to be immersed in the silver nitrate Ag
+Be reduced in the shitosan that argent is deposited on crosslinked.U.S. Pat 5420197 discloses a kind of stabilizing gel, and wherein antimicrobial component comprises flamazine, and gel rubber material is a shitosan.
Summary of the invention
The purpose of this invention is to provide a kind of silver-containing antibacterial material and preparation method thereof and application.
For achieving the above object, the present invention takes following technical scheme:
A kind of silver-containing antibacterial material is made up of chitin and/or its derivative host and the Ag-containing compound that adheres on it thereof basically.
Described Ag-containing compound is silver oxide, silver peroxide or silver ion.
Described chitin derivativ is chitosan and carboxymethyl chitosan.
Described silver oxide, silver peroxide or silver ion account for 0.001～25% of composition total weight.
Also contain percentage by weight in the described composition and be 75～99.99% chitosan or carboxymethyl chitosan.
Described adhesive is selected from copolymer, epoxy resin, white glue with vinyl, polyvinyl alcohol or the polyurethane of esters of acrylic acid, esters of acrylic acid and vinyl acetate.
A kind of silver-containing antibacterial preparation methods, step is as follows:
1) preparation contains the solvent of aqua ammonia or glacial acetic acid or adhesive;
2) silver oxide, silver peroxide are added in the solvent of step 1 configuration, stir, place, adjusting the pH value is 2～10.
3) powder, particle, fiber, woven cloth, nonwoven or the felt that chitin and/or its derivative are made put into the solution of step 2 configuration, soaked 30 minutes to 16 hours, or with the solution coat of step 2 configuration, spray on powder, particle, fiber, woven cloth, nonwoven or the felt that chitin and/or its derivative make, the distilled water rinsing, 50～100 ℃ of down oven dry 5 minutes to 3 hours, promptly get the silver-containing antibacterial material.
Described solvent is 5～80% Dilute Ammonia Solution or 5～80% glacial acetic acid solution.
Also add adhesive in described step 2 solution.
Described adhesive is selected from copolymer, epoxy resin, white glue with vinyl, polyvinyl alcohol or the polyurethane of esters of acrylic acid, esters of acrylic acid and vinyl acetate.
The inventor studies show that, because the silver-containing antibacterial material has strong anti-microbial property, can be used for preparing bactericide and antibiotic material in medical use.
Described bactericide comprises the medicine of the gel, membrane agent, dried jelly, artificial skin or the treatment wound that are loaded with the silver-containing antibacterial material composition.
Described bactericide, can be further used for making have microbe killing properties can daily necessities.
The described daily necessities that has microbe killing properties energy comprises adult-incontinence articles, sanltary towel, baby paper diaper, underwear, clothes, shoe-pad, wallpaper, curtain, footwear or sofa or automobile lining cloth, bedding, filter screen filter cloth, agent of deodorising and sterilizing, deodorizing sterilizing device, water purification installation and cosmetics.
Described antibiotic material in medical use comprises woven cloth, nonwoven, felt and fiber and the medical antibacterial dressing thereof that is loaded with the silver-containing antibacterial material.
In silver-containing antibacterial preparation methods disclosed by the invention, because silver oxide, silver peroxide can dissolve in Dilute Ammonia Solution and glacial acetic acid solution and not decompose, so most of molecular state with silver oxide, silver peroxide exists in solution, there is the small amount of silver ion to exist.Wherein silver oxide, silver peroxide major part are deposited on chitin and the derivative thereof.The saccharide residue of chitin and derivative thereof is at C
2On an acetylamino or amino are arranged, at C
3On a hydroxyl is arranged, on conformation, all be equatorial bond, this special structure makes them be closed by huge legendary turtle under pH=2～10 conditions the silver ion in the solution.
In silver-containing antibacterial preparation methods disclosed by the invention, owing to utilize adhesive, silver oxide or silver peroxide are fixed on the powder or particle of chitin and derivative thereof, or be fixed on the fiber that contains chitin and derivative thereof, woven cloth, nonwoven and the felt, silver oxide or silver peroxide are slowly discharged play bactericidal action.Preparation method disclosed by the invention has realized evenly being coated with or adsorbing the purpose of silver peroxide, and has made silver ion and chitin and derivative chelating thereof on chitin and derivative thereof.Preparation method of the present invention, technology is simple, is suitable for industrial-scale production.The chitin of argentiferous provided by the invention and the composition of derivative thereof are a kind of novel silver-containing antibacterial materials.Utilize chitin and derivative thereof to have the stable performance of biological degradation, safety non-toxic, good biocompatibility and chemical property, with silver peroxide with silver ion is organic combines, do not destroy its chemical property.Compare with existing anti-biotic material and to have tangible advantage.
The silver-containing antibacterial material is applied to prepare bactericide and antibiotic material in medical use field, has broad prospects.
Description of drawings
Fig. 1 is the application schematic diagram that silver-containing antibacterial material of the present invention applies at medical antibacterial
Fig. 2 is the application schematic diagram of silver-containing antibacterial material of the present invention on adult-incontinence articles
Embodiment
Below by specific embodiment the present invention is elaborated.
Embodiment 1: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
(1) the Dilute Ammonia Solution 1000ml of preparation 10%.
(2) 10 gram silver oxides or silver peroxides are joined in 10% the Dilute Ammonia Solution, through stirring, placing, regulating its pH value is 7.5.
(3) with the powder or the particle of chitin and derivative thereof, or be loaded with the fiber of chitin and derivative thereof, woven cloth, nonwoven and felt, put into the solution of step 2, soaked 6 hours, through the abundant rinsing of distilled water, remove residual aqua ammonia,, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material then 85 ℃ of down oven dry 3 hours.
Embodiment 2: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
(1) the Dilute Ammonia Solution 1000ml of preparation 15%.
(2) 10 gram silver oxides or silver peroxides are joined in 15% the Dilute Ammonia Solution, through stirring, placing, regulating its pH value is 8.0.
(3) with the powder or the particle of chitin and derivative thereof, or be loaded with the fiber of chitin and derivative thereof, woven cloth, nonwoven and felt, put into step 2, soaked 4 hours, through the abundant rinsing of distilled water, remove residual aqua ammonia,, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material then 75 ℃ of down oven dry 2 hours.
Embodiment 3: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
(1) the glacial acetic acid solution 1000ml of preparation 45%.
(2) 10 gram silver oxides or silver peroxides are added in 45% the glacial acetic acid solution, through stirring, placing, regulating its pH value is 4.
(3) with the powder or the particle of chitin and derivative thereof, or be loaded with the fiber of chitin and derivative thereof, woven cloth, nonwoven and felt, put into the solution of step 2, soaked 2 hours, through the abundant rinsing of distilled water, remove residual glacial acetic acid,, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material then 60 ℃ of down oven dry 1 hour.
Embodiment 4: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
(1) the glacial acetic acid solution 1000ml of preparation 30%.
(2) 10 gram silver oxides or silver peroxides are added in 30% the glacial acetic acid solution, through stirring, placing, regulating its pH value is 3.
(3) with the powder or the particle of chitin and derivative thereof, or be loaded with the fiber of chitin and derivative thereof, woven cloth, nonwoven and felt, put into the solution of step 2, soaked 30 minutes, through the abundant rinsing of distilled water, remove residual glacial acetic acid,, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material then 70 ℃ of down oven dry 1 hour.
Embodiment 5: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
(1) the polyacrylic resin solution 1000ml of preparation 50%.
(2) 10 gram silver oxides or silver peroxides are added in 50% the polyacrylic resin solution, through stirring, placing, regulating its pH value is 5.5.
(3) with the powder or the particle of chitin and derivative thereof, or be loaded with the fiber of chitin and derivative thereof, woven cloth, nonwoven and felt, put into the solution of step 2, soaked 8 hours, through the abundant rinsing of distilled water, remove residual polyacrylic resin,, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material then 50 ℃ of oven dry 5 minutes.
Embodiment 6: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
With the solution of any routine step 2 in embodiment 1,2,3,4 or 5, be sprayed directly on the powder or particle of the chitin of argentiferous and derivative thereof; Or be sprayed directly on woven cloth, nonwoven, felt or the fiber that is loaded with chitin and derivative thereof, 70 ℃ of down oven dry 4 hours, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
Embodiment 7: silver-containing antibacterial material and be loaded with the preparation of woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
In embodiment 1,2,3 or 4, in the solution of any routine step 2, directly add polyacrylic resin, and then be applied on the powder or particle of chitin and derivative thereof; Or be sprayed directly on woven cloth, nonwoven, felt or the fiber that is loaded with chitin and derivative thereof, 70 ℃ of down oven dry 3 hours, promptly get the silver-containing antibacterial material or be loaded with woven cloth, nonwoven, felt or the fiber of silver-containing antibacterial material.
The inventor shows by the comparative studies to the minimum inhibitory concentration of different bacterium of silver peroxide, chitin and derivative thereof and silver-containing antibacterial material, after silver oxide and chitin and derivative huge legendary turtle thereof are closed, the argentiferous chitin that forms and the composition of derivative thereof, its anti-microbial property obviously is better than silver oxide, chitin or/and and the independent anti-microbial property of derivative.Result relatively is shown in table 1～table 3.
Table 1: silver peroxide is to the minimum inhibitory concentration of different bacterium
| Bacterial culture | Silver peroxide MIC concentration (ppm/ml) |
| Staphylococcus aureus | 10 |
| Bacillus cereus | 25 |
| Escherichia coli | 18 |
| Pseudomonas aeruginosa | 12 |
| Comma bacillus | 11 |
| Microsporum canis | 11 |
| Acrothesium floccosum | 6 |
| Candida albicans | 35 |
| Spherical chlosma | 22 |
Table 2: chitin and derivative thereof are to the minimum inhibitory concentration of different bacterium
| Bacterial culture | Chitin and derivative MIC concentration (ppm/ml) thereof | |||
| DD69 | SC1 | SC2 | SBC | |
| Staphylococcus aureus | 100 | 100 | ＞2000 | 200 |
| Bacillus cereus | 1000 | 500 | --- | ＞2000 |
| Escherichia coli | 100 | 100 | --- | 100 |
| Pseudomonas aeruginosa | 200 | 200 | ＞2000 | 100 |
| Comma bacillus | 200 | ＞2000 | ＞2000 | 2000 |
| Microsporum canis | 200 | 500 | 1000 | 1000 |
| Acrothesium floccosum | 500 | 100 | ＞2000 | 2000 |
| Candida albicans | 300 | 300 | 400 | 1000 |
| Spherical chlosma | 200 | 200 | ＞2000 | 2000 |
Annotate: DD69-69% deacetylation shitosan; SC1-0.63% sulphation shitosan; SC2-13.03% sulphation shitosan; SBC-benzene sulfated chitosan.
Table 3: the silver-containing antibacterial material is to the minimum inhibitory concentration (argentiferous 1%) of different bacterium
| Bacterial culture | Silver-containing antibacterial material MIC concentration (ppm/ml) | |||
| Argentiferous DD69 | Argentiferous SC1 | Argentiferous SC2 | Argentiferous SBC | |
| Staphylococcus aureus | 20 | 20 | 200 | 30 |
| Bacillus cereus | 80 | 100 | --- | 800 |
| Escherichia coli | 10 | 10 | --- | 10 |
| Pseudomonas aeruginosa | 20 | 20 | 800 | 30 |
| Comma bacillus | 20 | 500 | 1000 | 500 |
| Microsporum canis | 40 | 50 | 20 | 50 |
| Acrothesium floccosum | 200 | 100 | 1000 | 800 |
| Candida albicans | 20 | 30 | 50 | 100 |
| Spherical chlosma | 30 | 20 | 1000 | 800 |
Annotate: argentiferous DD69-contains 69% deacetylation shitosan of silver peroxide and small amount of silver ion (1%);
Argentiferous SC1-contains 0.63% sulphation shitosan of silver oxide and small amount of silver ion (1%);
Argentiferous SC2-contains 13.03% sulphation shitosan of silver peroxide and small amount of silver ion (1%);
Argentiferous SBC-contains the benzene sulfated chitosan of silver oxide and small amount of silver ion (1%).
Embodiment 8: the preparation of silver-containing antibacterial material film agent.
Get the silver-containing antibacterial material powder that any example obtains in embodiment 1,2,3,4,5,6 or 7, be dissolved in the mixed solvent of water and ethanol or acetone (ratio of water and organic solvent is 6: 4), stir, then with mixture hydrostomia film forming on optical flat, 0.5～15 μ m, 40 ℃ down heating mix and do, be coated with in the one side of film again and be covered with pressure sensitive adhesive, be cut into the membrane agent of different size, become a kind of medical bactericide.
Embodiment 9: the preparation of silver-containing antibacterial material gel.
Get any example obtains in embodiment 1,2,3,4,5,6 or 7 silver-containing antibacterial material powder or particle 10 grams, mix for 2 milliliters with sodium carboxymethylcellulose 15 grams, humectant propane diols, adding distil water to 100 gram, stir, get the silver-containing antibacterial material gel, packing gets final product then, becomes a kind of medical bactericide.
Embodiment 10: the application of argentiferous chitin and derivative antibiotic material in medical use thereof-membrane agent preparation
Get chitosan composition 16 grams of argentiferous 0.1%, add 750 ml distilled waters, under agitation drip 7 milliliters of hydrochloric acid, added back 1 hour, the pH value of solution is 3.0.Other gets 16 gram gelatin, dissolves in 90 milliliters 50 ℃ distilled water, takes advantage of heat to pour in the argentiferous chitosan solution, stirs 30 minutes, and this moment, the pH value was 4.8.Then in 2 hours, while stirring with about 48 milliliters 5%NaHCO
3Solution is added dropwise in the above-mentioned argentiferous chitosan solution, and regulating the pH value is 5.7.In addition, 6.4 gram glycerine are dissolved in 20 ml distilled waters, be added in the above-mentioned mixed solution, stirred 15 minutes, use the polyester cloth suction filtration, remove insoluble matter, filtrate is diluted with 100 ml distilled waters, casting film-forming on polystyrene plate then, air drying 7 days, carefully take film off, packing gets final product.
Embodiment 11: the application of silver-containing antibacterial material in medical antibacterial dressing.
As shown in Figure 1, the woven cloth, nonwoven or the fiber that are loaded with the silver-containing antibacterial material that any example among embodiment 1,2,3,4 or 5 is prepared is as the antibiotic layer 2 of medical dressing, nexine 3 addings promotion bioactivator of wound healing at medical dressing comprises growth factor, collagen, hyaluronic acid etc. again, the skin 1 of medical dressing is a separation layer, the medical dressing that above three-decker is made is used for the nursing of various wounds.
Embodiment 12: the application of silver-containing antibacterial material on adult-incontinence articles.
As shown in Figure 2, the innermost layer of adult-incontinence articles (promptly pressing close to one deck of human body skin) is cotton yarn layer of cloth 1; The outside successively second layer is the nonwoven that is loaded with the silver-containing antibacterial material or the antibiotic layer 2 of fiber, and antibiotic layer 2 is made by prepared nonwoven that is loaded with the silver-containing antibacterial material or the fiber of any example among embodiment 1,2,3,4 or 5; Outside successively the 3rd layer is water accepting layer 3; Outside successively the 4th layer is antiseized nonwoven layer 4, and above four-layer structure is made a kind of adult-incontinence articles that is loaded with the silver-containing antibacterial material.
Claims (15)
1, a kind of silver-containing antibacterial material is made up of chitin and/or its derivative host and the Ag-containing compound that adheres on it thereof basically.
2, silver-containing antibacterial material as claimed in claim 1 is characterized in that: described Ag-containing compound is silver oxide, silver peroxide or silver ion.
3, silver-containing antibacterial material as claimed in claim 1 or 2 is characterized in that: described chitin derivativ is chitosan and carboxymethyl chitosan.
4, silver-containing antibacterial material as claimed in claim 1 or 2, it is characterized in that: described silver oxide, silver peroxide or silver ion account for 0.001～25% of composition total weight.
5, silver-containing antibacterial material as claimed in claim 1 or 2 is characterized in that: also contain percentage by weight in the described composition and be 75～99.99% chitosan or carboxymethyl chitosan.
6, silver-containing antibacterial material as claimed in claim 5 is characterized in that: described adhesive is selected from copolymer, epoxy resin, white glue with vinyl, polyvinyl alcohol or the polyurethane of esters of acrylic acid, esters of acrylic acid and vinyl acetate.
7, a kind of silver-containing antibacterial preparation methods, step is as follows:
1) preparation contains the solvent of aqua ammonia or glacial acetic acid or adhesive;
2) silver oxide, silver peroxide are added in the solvent of step 1 configuration, stir, place, adjusting the pH value is 2～10;
3) powder, particle, fiber, woven cloth, nonwoven or the felt that chitin and/or its derivative are made put into the solution of step 2 configuration, soaks 30 minutes to 16 hours; Or with the solution coat of step 2 configuration, spray on powder, particle, fiber, woven cloth, nonwoven or the felt that chitin and/or its derivative make, distilled water rinsing, 50～100 ℃ of oven dry 5 minutes to 3 hours promptly gets the silver-containing antibacterial material.
8, silver-containing antibacterial preparation methods as claimed in claim 7 is characterized in that: described solvent is 5～80% Dilute Ammonia Solution or 5～80% glacial acetic acid solution.
9, silver-containing antibacterial preparation methods as claimed in claim 7 is characterized in that: also add adhesive in described step 2 solution.
10, as claim 7 or 8 or 9 described silver-containing antibacterial preparation methods, it is characterized in that: described adhesive is selected from copolymer, epoxy resin, white glue with vinyl, polyvinyl alcohol or the polyurethane of esters of acrylic acid, esters of acrylic acid and vinyl acetate.
11, the application of a kind of silver-containing antibacterial material on preparation bactericide and antibiotic material in medical use.
12, application as claimed in claim 11 is characterized in that: described bactericide is the medicine of gel, membrane agent, dried jelly, artificial skin or treatment wound.
13, the application of silver-containing antibacterial material in the preparation daily necessities.
14, application as claimed in claim 13 is characterized in that: the described daily necessities that has microbe killing properties energy comprises adult-incontinence articles, sanltary towel, baby paper diaper, underwear, clothes, shoe-pad, wallpaper, curtain, footwear or sofa or automobile lining cloth, bedding, filter screen filter cloth, agent of deodorising and sterilizing, deodorizing sterilizing device, water purification installation or cosmetics.
15, application as claimed in claim 9 is characterized in that: described antibiotic material in medical use comprises woven cloth, nonwoven, felt and fiber and the medical antibacterial dressing thereof that is loaded with the silver-containing antibacterial material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410069799 CN1723778A (en) | 2004-07-20 | 2004-07-20 | Silver-contg. type antibiotic agent, prepn. method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410069799 CN1723778A (en) | 2004-07-20 | 2004-07-20 | Silver-contg. type antibiotic agent, prepn. method and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1723778A true CN1723778A (en) | 2006-01-25 |
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ID=35923508
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|---|---|---|---|
| CN 200410069799 Pending CN1723778A (en) | 2004-07-20 | 2004-07-20 | Silver-contg. type antibiotic agent, prepn. method and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012106983A1 (en) * | 2011-02-11 | 2012-08-16 | 佛山市优特医疗科技有限公司 | Antibacterial fibrous dressing containing nano-sized metal and preparation method thereof |
| CN101024798B (en) * | 2007-02-06 | 2012-10-10 | 陕西科技大学 | Method for preparing porcelain washing liquid |
| CN104324407A (en) * | 2014-09-26 | 2015-02-04 | 福州大学 | Preparation method of nano silver chloride/chitosan fiber anti-bacterial dressing |
| CN104863007A (en) * | 2015-04-03 | 2015-08-26 | 华南理工大学 | Chitin crystal bar-based nano-silver composite antibacterial paper, and preparation method and application thereof |
| CN105669251A (en) * | 2016-01-03 | 2016-06-15 | 安徽律正科技信息服务有限公司 | Antimicrobial agent for glass ceramic |
| CN107938374A (en) * | 2017-12-20 | 2018-04-20 | 合肥洁诺无纺布制品有限公司 | A kind of preparation method of the medical coated non-woven of anti-pollution type |
| CN108060585A (en) * | 2017-12-20 | 2018-05-22 | 合肥洁诺无纺布制品有限公司 | A kind of preparation method of high-strength medical coated non-woven |
| CN110584239A (en) * | 2019-09-04 | 2019-12-20 | 深圳市圆方科技新材料有限公司 | Antibacterial mask and manufacturing method thereof |
| CN111962307A (en) * | 2020-08-06 | 2020-11-20 | 南京诺全生物医疗科技有限公司 | Antibacterial material capable of providing nitric oxide by itself and preparation method and application thereof |
| CN112402684A (en) * | 2020-11-25 | 2021-02-26 | 联科华技术有限公司 | Monoatomic antibacterial disinfecting hemostatic gauze and preparation method thereof |
-
2004
- 2004-07-20 CN CN 200410069799 patent/CN1723778A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024798B (en) * | 2007-02-06 | 2012-10-10 | 陕西科技大学 | Method for preparing porcelain washing liquid |
| WO2012106983A1 (en) * | 2011-02-11 | 2012-08-16 | 佛山市优特医疗科技有限公司 | Antibacterial fibrous dressing containing nano-sized metal and preparation method thereof |
| CN104324407B (en) * | 2014-09-26 | 2016-01-27 | 福州大学 | The preparation method of a kind of nano silver/silver chloride/chitin fiber antiseptic dressing |
| CN104324407A (en) * | 2014-09-26 | 2015-02-04 | 福州大学 | Preparation method of nano silver chloride/chitosan fiber anti-bacterial dressing |
| CN104863007B (en) * | 2015-04-03 | 2017-04-19 | 华南理工大学 | Chitin crystal bar-based nano-silver composite antibacterial paper, and preparation method and application thereof |
| CN104863007A (en) * | 2015-04-03 | 2015-08-26 | 华南理工大学 | Chitin crystal bar-based nano-silver composite antibacterial paper, and preparation method and application thereof |
| CN105669251A (en) * | 2016-01-03 | 2016-06-15 | 安徽律正科技信息服务有限公司 | Antimicrobial agent for glass ceramic |
| CN107938374A (en) * | 2017-12-20 | 2018-04-20 | 合肥洁诺无纺布制品有限公司 | A kind of preparation method of the medical coated non-woven of anti-pollution type |
| CN108060585A (en) * | 2017-12-20 | 2018-05-22 | 合肥洁诺无纺布制品有限公司 | A kind of preparation method of high-strength medical coated non-woven |
| CN110584239A (en) * | 2019-09-04 | 2019-12-20 | 深圳市圆方科技新材料有限公司 | Antibacterial mask and manufacturing method thereof |
| CN111962307A (en) * | 2020-08-06 | 2020-11-20 | 南京诺全生物医疗科技有限公司 | Antibacterial material capable of providing nitric oxide by itself and preparation method and application thereof |
| CN111962307B (en) * | 2020-08-06 | 2023-02-03 | 南京诺令生物科技有限公司 | Antibacterial material capable of providing nitric oxide by itself and preparation method and application thereof |
| CN112402684A (en) * | 2020-11-25 | 2021-02-26 | 联科华技术有限公司 | Monoatomic antibacterial disinfecting hemostatic gauze and preparation method thereof |
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