CN100394986C - Wound dressing containing Ag-Zn composition - Google Patents
Wound dressing containing Ag-Zn composition Download PDFInfo
- Publication number
- CN100394986C CN100394986C CNB200410090621XA CN200410090621A CN100394986C CN 100394986 C CN100394986 C CN 100394986C CN B200410090621X A CNB200410090621X A CN B200410090621XA CN 200410090621 A CN200410090621 A CN 200410090621A CN 100394986 C CN100394986 C CN 100394986C
- Authority
- CN
- China
- Prior art keywords
- zinc
- argentiferous
- composition
- wound dressing
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000000203 mixture Substances 0.000 title claims abstract description 161
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- 239000011701 zinc Substances 0.000 claims abstract description 187
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 81
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 81
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 47
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- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 6
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- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 4
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
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Abstract
The present invention relates to a wound dressing containing silver-zinc compositions, which is composed of carriers and compositions containing silver and zinc attached to the carriers. The compositions containing silver and zinc comprise one or more than one of H4Ag2O6 solution, silver peroxide and silver oxide, and zinc salt as effective components. High molecular materials, inorganic minerals or active carbon is used as the carriers. The compositions containing silver and zinc are attached to the carriers with the methods of impregnating, applying, spraying and adsorbing, wherein the weight part ratio of silver to zinc is 1:0.01 to 100. The dressing has simple manufacture technology and low cost. The prepared wound dressing can be used for treating infected wounds, operative incisions, surgical wounds, body surface ulcers, various burns, scalds, wounds, etc., and thus, has wide range of application.
Description
Technical field
What the present invention relates to is medical wound dressing, particularly relates to a kind of wound dressing of argentiferous Zn composition.
Background technology
Skin is the barrier of keeping the health homeostasis and stoping the microorganism invasion.The many parts that take place after wound, burn and the health ulcer are sick and wounded relevant with the forfeiture skin barrier with general, rebuilding or recovering skin barrier is one of free-revving engine of treatment wound, burn and health ulcer etc., so an ideal wound dressing should possess following characteristics: 1. promote wound healing; 2. quick-acting haemostatic powder; 3. protect from infection; 4. good healing environment is provided.
Some wound dressings are preferably also arranged in the prior art, the for example wound dressing of developing with collagen protein, chitosan, antibacterial etc., certain superiority is all arranged on performance, but there are some problems in they in application, for example anthemorrhagic speed and effect are undesirable, and antibiotic infection performance also still awaits improving.
Silver is applied in the antiseptic dressing, antibiotic anti-infection property and the promotion healing ability that improves wound dressing had effect preferably.In existing antiseptic dressing technology, use wider argentiferous composition silver sulfadiazine, argentoproteinum are arranged and utilize silver nitrate for raw material and Organic substance for the dressing of preparing carriers etc., but these argentiferous compositions or method exist many problems to need to solve in actual application, for example: part patient is to sulfa drugs allergy, thereby inapplicable silver sulfadiazine; Argentoproteinum should use very inconvenient owing to cannot say for sure to deposit; Utilize the dressing of silver nitrate for feedstock production, because the existence of a large amount of nitrate anions and other foreign ion is arranged, thereby be unfavorable for wound healing.
Along with the further investigation of people to silver-colored anti-microbial property, find that the anti-microbial property of silver and the valence state of silver have very confidential relation, the high more antibacterial ability of valence state of silver is strong more.Wherein bivalence silver and trivalent silver bactericidal effect is 50～200 times of the silver-colored and argent of monovalence, and the sterilization speed of trivalent silver compound than silver-colored fast 240 times of monovalence (Soap/Cosmetics/Chemical Specialties, March, 1994, page52).In silver compound, H
4Ag
2O
6Contain high price silver with silver peroxide, and silver peroxide itself contains active oxygen, so anti-microbial property is better than other chemical compound of silver.The applicant holds Patent right Chinese patent ZL97108681.8, discloses H
4Ag
2O
6Preparation method as follows: (1) gets the oxide (comprising silver oxide or silver peroxide) of silver, adds distilled water; (2) after the stirring, add concentrated sulphuric acid, adjust pH value; (3) pour out clear liquor after the clarification, obtain precipitate; (4) in precipitate, add hydrogen peroxide, obtain H
4Ag
2O
6U.S. Pat 6436420B1 discloses silver peroxide has been applied to content in the antibiotic fabric.We find under study for action, and are though the antibacterial effect of silver is fine, still undesirable to the antibacterial effect of fungus.
The medical circle current research shows that zinc plays a very important role to wound healing.The reparation of wound tissue comprises a series of pathological changes such as fibroblast proliferation, collagen protein synthesis, collagen fiber maturation and the increase of wound tensile strength, and in this process, the physiological function that zinc element had has caused the attention of brainstrust.This is because zinc is the cofactor or the activation factor of 200 plurality of enzymes such as body archaeal dna polymerase, RNA polymerase, lactic acid dehydrogenase, so for sufficient energy supply of wound location and tissue regeneration important function is arranged.
Histochemistry experiment confirm, zinc are present in the nucleus, are the indispensable factors of cell division.The bonded ratio of thymidine and DNA precursor descends during zinc deficiency, and dna content reduces in the tissue, influences histiocyte and grows normally, repairs and breed.Human body is taken in the zinc deficiency, shows serum albumin, prealbumin and retinaldehyde binding protein level and all descends, and carbamide row is rushed down also minimizing etc.In addition, the research data of relevant wound nutrition both at home and abroad proves further that also traumatic organism fibroblast proliferation number reduced when zinc was not enough, and the collagen synthetic quantity reduces, and the wound scar tissue is ripe slow, thereby its tensile strength is significantly lower.
Zinc truly has the effect that promotes healing in processes of wound repair, thereby reduces or shortage for the caused zinc of wound, must in time be replenished, and promotes wound healing.
Zinc also is a kind of traditional inorganic fungicide.Zinc is as anti-biotic material, and it is inchoate in recent years being paid attention to by people.Though the antibacterial ability of zinc ion is not as good as silver ion, the zinc ion antifungal is can the force rate silver ion strong, and is will zinc ion eager to excel in whatever one does to the more independent silver ion of the sterilization effect of fungus and mycete with silver ion combination back.
The compositions of argentiferous, zinc is used for anti-biotic material, existing in the prior art, for example: Chinese patent 00112519.2 discloses a kind of silver-colored Zn composition antibacterial, by aminoacid silver and amino-acid zinc, with and the argent that decompose to generate, the antibiotic property motif material that zinc oxide is formed antibacterial.Though this technology is combined as antibacterial with silver and zinc, the concentration of its silver ion is low, and the valence state of silver is also low, so its anti-microbial property is restricted; Utilize silver sulfadiazine and zinc sulfadiazine to be used for dressing in addition, but can't use and antibacterial effect has much room for improvement sulfa drugs patient hypersensitive.
Summary of the invention
At the problems referred to above, the purpose of this invention is to provide a kind of wound dressing of argentiferous Zn composition.
For achieving the above object, the present invention takes following technical scheme: a kind of wound dressing of argentiferous Zn composition, combination material by the argentiferous that adheres on carrier and the carrier, zinc composition is formed, and it is characterized in that: the combination material of described argentiferous, zinc composition comprises following composition: H
4Ag
2O
6Solution and silver peroxide (Ag
2O
2) at least a and zinc salt; Wherein silver is silver with the ratio of weight and number of zinc: zinc=1: 0.01～100.
Described zinc salt is selected from one or more in zinc sulfate, zinc nitrate, zinc acetate, zinc lactate, zinc gluconate, ethylenediaminetetraacetic acid zinc, malic acid zinc or the zinc citrate.
Described carrier is selected from a kind of in macromolecular material, inorganic mineral or the active carbon.
Described macromolecular material is selected from natural fiber and yarn fabric thereof, non-woven fabrics, foam plastics, biological fiber and woven fabric thereof, knitted fabric, non-woven fabrics and other polymer substance.Described foam plastics can be RPUF, flexible polyurethane foam, polystyrene foam plastics or polyethylene foams; Described biological fiber can be chitosan fiber powder, granule and woven fabric thereof, knitted fabric, non-woven fabrics or collagen fiber powder, granule and woven fabric thereof, knitted fabric, non-woven fabrics or alginic acid fibre powder, granule and woven fabric thereof, knitted fabric, non-woven fabrics; Described other polymer substance is selected from viscose glue, polypropylene and polypropylene fibre, polyethylene, polyurethane fibre, aramid fiber, poly-acetate, polyacrylic acid, polyacrylic acid amide, acrylic acid and acrylamide copolymer, polyurethane and polyurethane fiber, polyvinyl alcohol, polyvinyl alcohol and anhydride cross-linking agent, polyvinyl alcohol and acrylic acid graft copolymer, vinyl acetate and acrylate copolymerization hydrolysate, Polyethylene Glycol, polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, the fibre grafting acrylates, the fibre grafting acrylate, cellulose xanthogenation grafted propylene hydrochlorate, carbomer, hydroxyethyl-cellulose, arabic gum, corn starch, starch graft acrylamide, starch grafted acrylate, starch-grafted propylene fat, HANSHENGJIAO, lac, sodium alginate, gelatin, pectin, xanthan gum, collagen protein, hyaluronic acid, somatomedin, heparin, in chondroitin sulfate or the carboxymethyl starch one or more.
Described inorganic mineral is selected from one or more in graphite, bentonite, Kaolin, zeolite, Montmorillonitum, meerschaum, Gypsum Fibrosum, white carbon, quartz sand, attapulgite, kieselguhr or the chalky soil.
Described active carbon can be woven fabric, knitted fabric, non-woven fabrics and the activated carbon felt of active carbon powder, granule or NACF.
The combination material of described argentiferous, zinc composition is attached on the described carrier with the method for dipping, coating, spraying, absorption.
The wound dressing of described argentiferous Zn composition can be processed into applicator material, membrane, gel, dried glue granule, spray, liniment and powder agent.
The wound dressing of described argentiferous Zn composition can be used for the treatment of infected wound, operative incision, surgical wound, ulcer in body surface, various burn wound.
The H that the present invention relates to
4Ag
2O
6Solution is the antiseptic solution that the present patent application people ZL97108681.8 patent application is provided.
The antibacterial that the present invention relates to is the composite bactericidal agent of silver and zinc.The purpose that adds zinc in the agent of argentiferous composite bactericidal singly is not the synergism that is their sterilizations in order to improve the weather resisteant of silver, to the more important thing is, studies show that, when the proportioning of zinc and silver reach one regularly its sterilization functions increase greatly, shown in table 1, table 2.
Table 1:
| Valence state (chemical compound) | Ag％ | Zn％ | To Candida albicans sterilizing rate % (10 minutes 6.6 * 10 5cfu/ml) |
| Ag +(AgNO 3) | 0.01 | 0 | 87.31 |
| Ag 4+(H 4Ag 2O 6) | 0.01 | 0 | 98.05 |
| Ag 4+(H 4Ag 2O 6) | 0.01 | 1.0 | 99.99 |
| Silver oxide | 0.1 | 0 | 86.42 |
| Silver oxide | 0.1 | 1.0 | 98.91 |
| Silver peroxide | 0.1 | 0 | 90.10 |
| Silver peroxide | 0.1 | 1.0 | 99.80 |
Table 2:
| NO | Ag％(Ag 4+) | Zn％ | To Candida albicans sterilizing rate % (10 minutes 5.25 * 10 5cfu/ml) |
| 1 | 0.01 | 0 | 97.45 |
| 2 | 0.01 | 0.01 | 99.72 |
| 3 | 0.01 | 0.03 | 99.95 |
| 4 | 0.01 | 0.05 | 99.91 |
| 5 | 0.01 | 0.10 | 99.85 |
| 6 | 0.01 | 0.20 | 99.57 |
| 7 | 0.01 | 0.30 | 98.10 |
| 8 | 0.01 | 0.50 | 97.70 |
| 9 | 0.01 | 1.0 | 97.30 |
With natural fiber and yarn fabric thereof, non-woven fabrics, foam plastics is the wound dressing of the argentiferous Zn composition of the present invention of preparing carriers, is mainly used in general Wound care; With biological fiber and woven fabric thereof, knitted fabric, non-woven fabrics is the wound dressing of the argentiferous Zn composition of the present invention of preparing carriers, be mainly used in the nursing of special wound,, ulcer dark such as wound, operation wound etc., it can play antibiotic, promoting healing effect and without any side effects to human body.To be that the wound dressing of the argentiferous Zn composition of the present invention of preparing carriers has antibiotic, promoting healing and hemostatic effect with suction macromolecular material, active carbon and inorganic mineral, can be used for hemorrhage more wound.
The present invention is owing to take above technical scheme, and it has the following advantages: (1) wound dressing of the present invention has the effect of antibiotic, hemostasis, antiinflammatory, absorption wound surface exudate, deodorization and promotion wound healing, and the scope of application is extensive; (2) compositions of the argentiferous in the wound dressing of the present invention, zinc does not contain acid group and other harmful ion; (3) compositions of the argentiferous in the wound dressing of the present invention, zinc has the synergism of silver and zinc, and antibacterial action increases greatly; Desilver and zinc itself have outside the effect that promotes wound healing, add hemostasis that the special carrier material of dressing had and the effect that promotes wound healing, and the healing speed of wound is obviously accelerated; (4) wound dressing processing technology of the present invention is simple, and cost is low, is suitable for suitability for industrialized production, is widely used in the Wound care field, is a kind of ideal wound dressing.
The specific embodiment
Embodiment 1: with natural fiber or its yarn fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
Preparation H
4Ag
2O
6Solution: silver peroxide 500 grams are put into reaction pot, add 100 kilograms of deionized waters, be mixed with silver-containing solution; Stir silver-containing solution after 15 minutes, add 125 milliliters in perchloric acid, the pH value of regulating silver-containing solution is 2; Continue to stir then 2 hours, and dropwise added concentration again and be 600 milliliters of 15% hydrogen peroxide when pH value is stabilized in 2, restir got final product in 30 minutes.H
4Ag
2O
6The weight of contained silver ion accounts for 0.4% of mother solution weight in the solution.
The compositions of preparation argentiferous, zinc (parts by weight silver: zinc=1: 0.01): 100 gram zinc acetates are put into the dosing pot, add the H of above-mentioned preparation gradually
4Ag
2O
612 kilograms of solution stir while adding, and stir to get final product in 30 minutes, and silver content is 0.4% in the compositions liquid of prepared argentiferous, zinc, the content of zinc is 0.004%.
The argentiferous of above-mentioned preparation, the compositions liquid of zinc are poured in the liquid bath for 10 kilograms, again natural fiber or its yarn fabric, non-woven fabrics are kept flat in the compositions liquid of argentiferous in the liquid bath, zinc and soaked 30 minutes, the taking-up of immersion back is dried in the shade or is dried, and sterilizes then, packs.The wound dressing of made argentiferous Zn composition can promote the healing of various burn wounds, surgery damage wound, surgical wound, chronic surface ulcers etc.
Embodiment 2: with chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
Preparation H
4Ag
2O
6The method of solution is identical with embodiment 1.
The compositions of preparation argentiferous, zinc (parts by weight silver: zinc=1: 1): 1000 gram zinc acetates are put into the dosing pot, add the H of above-mentioned preparation gradually
4Ag
2O
612 kilograms of solution stir while adding, and stir to get final product in 30 minutes, and silver content is 0.4% in the compositions liquid of prepared argentiferous, zinc, the content of zinc is 0.4%.
The argentiferous of above-mentioned preparation, the compositions liquid of zinc are poured in the liquid bath for 10 kilograms, again chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics are kept flat in the compositions liquid of argentiferous in the liquid bath, zinc, soaked 30 minutes, the taking-up of immersion back is dried in the shade or is dried, and sterilizes then, packs.The wound dressing of made argentiferous Zn composition can promote the healing of various burn wounds, surgery damage wound, surgical wound, chronic surface ulcers etc.
Embodiment 3: with alginate fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
The argentiferous that embodiment 1 is prepared, the compositions of zinc (parts by weight silver: zinc=1: 0.01) pour in the liquid bath for 10 kilograms by liquid, again alginate fiber or its woven fabric, knitted fabric, non-woven fabrics are kept flat in the compositions liquid of argentiferous in the liquid bath, zinc and soaked 30 minutes, the taking-up of immersion back is dried in the shade or is dried, and sterilizes then, packs.The wound dressing of made argentiferous Zn composition can promote the healing of various burn wounds, surgery damage wound, surgical wound, chronic surface ulcers etc.
Embodiment 4: with chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
With 100 gram silver peroxide powder and 100 gram zinc lactate powder mixings, adding rare viscose glue then stirs for 2 kilograms, to mix and stir thing and be coated on chitosan fiber or its woven fabric, knitted fabric, the non-woven fabrics with coating machine, the wound dressing of argentiferous Zn composition is promptly made in 80 ℃ of oven dry.
Embodiment 5: with alginate fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
With 10 gram silver oxide powders and 100 gram zinc lactate powder mixings, adding rare viscose glue then stirs for 2 kilograms, to mix again and stir thing and be coated on alginate fiber or its woven fabric, knitted fabric, the non-woven fabrics with coating machine, 80 ℃ of oven dry, promptly make the wound dressing of argentiferous Zn composition, can be used for applicator material or stickup certainly.
Embodiment 6: with NACF or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
Preparation H
4Ag
2O
6The method of solution is identical with embodiment 1.
(parts by weight silver: zinc=1: 1) method is identical with embodiment 2 for the compositions of preparation argentiferous, zinc.
The argentiferous of above-mentioned preparation, the compositions liquid of zinc are poured in the liquid bath for 10 kilograms, again NACF or its woven fabric, knitted fabric, non-woven fabrics are kept flat in the compositions liquid of argentiferous in the liquid bath, zinc and soaked 30 minutes, the taking-up of immersion back is dried in the shade or is dried, and sterilizes then, packs.The wound dressing of made argentiferous Zn composition can be used for applicator material or stickup certainly, can promote the healing of various burn wounds, surgery damage wound, surgical wound, chronic surface ulcers etc.
Embodiment 7: with NACF and woven fabric thereof, knitted fabric, non-woven fabrics is the wound dressing of preparing carriers argentiferous Zn composition.
With 100 gram silver oxide powders and 50 gram zinc gluconate powder mixings, adding rare viscose glue then stirs for 2 kilograms, to mix again and stir thing and be sprayed on NACF or its woven fabric, knitted fabric, the non-woven fabrics with flush coater, 80 ℃ of oven dry, promptly make the wound dressing of argentiferous Zn composition, can be used for applicator material or stickup certainly.
Embodiment 8: be the wound dressing of preparing carriers argentiferous Zn composition with the active carbon powder.
(parts by weight silver: zinc=1: 1) method is identical with embodiment 2 for the compositions of preparation argentiferous, zinc.
1 kilogram of the active carbon of 200 mesh sieves will be crossed, join to mix in the compositions liquid of 5 kilograms of argentiferous, zinc of above-mentioned preparation and stirred 1 hour, filter then, wash, filter, dry down less than 60 ℃, grinding particle size to 1200 order, with the active carbon mix homogeneously of same weight and fineness, promptly get the hemostasis deodorization dressing of argentiferous Zn composition again.
Embodiment 9: the preparation of the wound dressing of membrane type argentiferous Zn composition.
30 gram polyurethane are joined in the 200ml ethanol and dissolve, add silver oxide 1 gram, zinc lactate 0.5 gram again, stir, continue to add chitosan 35 grams, stir, then with mixture sialorrhea film forming on optical flat, heating is mixed dried down at 30～50 ℃, be coated with in the one side of established thin film again and be covered with pressure sensitive adhesive, be cut into different size, make the membrane wound dressing of argentiferous Zn composition.
Embodiment 10: the preparation of the wound dressing of membrane type argentiferous Zn composition.
In 50 gram polyvinyl alcohol, add an amount of distilled water and make its dissolving, add silver peroxide 1.5 grams, malic acid zinc 1 gram again, stir, continue to add collagen protein 20 grams, chitosan 28 grams, stir, then with mixture sialorrhea film forming on optical flat, heating is mixed dried down at 30～50 ℃, be coated with in the one side of established thin film again and be covered with pressure sensitive adhesive, be cut into different size, make the film type wound dressing that contains biological polymeric compound composition and silver-colored Zn composition.
Embodiment 11: the preparation of the wound dressing of spray type argentiferous Zn composition.
(parts by weight silver: zinc=1: 0.01) 100 milliliters are mixed with 10 milliliters of glycerol, 5 milliliters of Oleum menthae, water-soluble chitosan fiber dust 5 grams with the compositions of embodiment 1 prepared argentiferous, zinc, add 80 milliliters of pure water again, stir, pack into and spray in the bottle, promptly make the wound dressing of spray type argentiferous Zn composition.
Embodiment 12: the preparation of the wound dressing of dried glue granular pattern argentiferous Zn composition.
Sodium carboxymethyl cellulose 40 grams, starch 10 grams, hydroxypropyl methyl fiber rope 10 grams, silver peroxide 0.5 gram, zinc gluconate 0.5 gram are mixed, add an amount of distilled water then and make its dissolving, mix homogeneously, granulate through 40 mesh sieves then, 50 ℃ of oven dry down, dried 30 minutes to 2 hours, again through 60 mesh sieve granulate, make the wound dressing of graininess argentiferous Zn composition, be applicable to the wound that transudate is more.
Embodiment 13: the preparation of the wound dressing of dried glue granular pattern argentiferous Zn composition.
With carboxymethyl starch sodium 30 grams, sodium alginate 20 grams, calcium alginate 10 grams and the argentiferous of embodiment 2 preparations, compositions (the parts by weight silver: 20 milliliters of mixing of liquid zinc=1: 1) of zinc, add an amount of distilled water again and make its dissolving, mix homogeneously, granulate through 40 mesh sieves then, 50 ℃ of oven dry down, dried 30 minutes to 2 hours, again through 60 mesh sieve granulate, make the wound dressing of graininess argentiferous Zn composition, this wound dressing can be made into bleeding-stopping dressing and be applied to heal a wound.
Embodiment 14: be the wound dressing of preparing carriers argentiferous Zn composition with the foam plastics.
It is to soak into 15 minutes in 1 ‰ the detergent liquid that flexible polyurethane foam is placed in concentration, wash with water clean then, putting into concentration again and be 1% Vc solution soaked into 2 minutes, add again embodiment 2 preparation argentiferous, (parts by weight silver: zinc=1: 1) liquid immersion is 2 minutes for the compositions of zinc, take out washing, airing then, promptly obtain the foam plastics of argentiferous Zn composition, can be used for applicator material or stickup certainly.
Embodiment 15: be the wound dressing of preparing carriers argentiferous Zn composition with the foam plastics.
It is to soak into 15 minutes in 1 ‰ the detergent liquid that polyethylene foams is placed in concentration, wash with water clean then, putting into concentration again and be 1% Vc solution soaked into 2 minutes, add again embodiment 1 preparation argentiferous, (parts by weight silver: zinc=1: 0.01) liquid immersion is 2 minutes for the compositions of zinc, take out washing then, airing promptly obtains the foam plastics of argentiferous Zn composition, can be used for applicator material or pastes certainly.
Embodiment 16: be the wound dressing of preparing carriers argentiferous Zn composition with the foam plastics.
It is to soak into 15 minutes in 1 ‰ the detergent liquid that polystyrene foam plastics is placed in concentration, wash with water clean then, putting into concentration again and be 1% Vc solution soaked into 2 minutes, add again embodiment 1 preparation argentiferous, (parts by weight silver: zinc=1: 0.01) liquid immersion is 2 minutes for the compositions of zinc, take out washing then, airing promptly obtains the foam plastics of argentiferous Zn composition, can be used for applicator material or pastes certainly.
The wound dressing of the various argentiferous Zn compositions that the foregoing description is prepared, the comparative result of its deodoriging properties is as shown in table 3.
Table 3: the wound dressing deodoriging properties of various argentiferous Zn compositions relatively
| The dressing title | Benzene-absorbing rate (wt%) |
| With natural fiber or its yarn fabric, non-woven fabrics is the wound dressing (embodiment 1) of the argentiferous Zn composition of carrier | 45-50 |
| With chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 2) of the argentiferous Zn composition of carrier | 40-45 |
| With alginate fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 3) of the argentiferous Zn composition of carrier | 40-50 |
| With chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 4) of the argentiferous Zn composition of carrier | 40-45 |
| With alginate fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 5) of the argentiferous Zn composition of carrier | 40-45 |
| With NACF or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 6) of the argentiferous Zn composition of carrier | 8-10 |
| With NACF and woven fabric thereof, knitted fabric, non-woven fabrics is the wound dressing (embodiment 7) of the argentiferous Zn composition of carrier | 8-10 |
| With the active carbon powder is the wound dressing (embodiment 8) of the argentiferous Zn composition of carrier | 7-9 |
| With the polyurethane foam plastics is the wound dressing (embodiment 14) of the argentiferous Zn composition of carrier | 30-35 |
| With the polyethylene foams is the wound dressing (embodiment 15) of the argentiferous Zn composition of carrier | 35-40 |
| With the polystyrene foam plastics is the wound dressing (embodiment 16) of the argentiferous Zn composition of carrier | 30-40 |
Embodiment 17: the preparation of the hemostasis powder dressing of argentiferous, Zn composition.
1 kilogram of bentonite is crossed 200 mesh sieves, join then by 5 kilograms of argentiferous of embodiment 2 preparations, compositions (the parts by weight silver: zinc=1: 1) in the liquid of zinc, mix and stirred 1 hour, washing more after filtration,, filtration, dry down less than 60 ℃, be crushed to 1200 orders again, the chitosan mix homogeneously of last and same weight and fineness promptly gets the hemostasis powder dressing of argentiferous Zn composition.
Embodiment 18: the preparation of the bleeding-stopping dressing of argentiferous Zn composition.
1 kilogram of bentonite is crossed 200 mesh sieves, join then by 5 kilograms of argentiferous of embodiment 2 preparations, compositions (the parts by weight silver: zinc=1: 1) in the liquid of zinc, mix and stirred 1 hour, washing more after filtration,, filtration, dry down less than 60 ℃, be crushed to 1200 orders again, the alginate mix homogeneously of last and same weight and fineness promptly gets the bleeding-stopping dressing of argentiferous Zn composition.
Embodiment 19: the preparation of the hemostasis powder dressing of argentiferous Zn composition.
1 kilogram of zeolite is crossed 200 mesh sieves, join then by 5 kilograms of argentiferous of embodiment 2 preparations, compositions (the parts by weight silver: zinc=1: 1) in the liquid of zinc, mix and stirred 1 hour, washing more after filtration,, filtration, dry down less than 60 ℃, be crushed to 1200 orders again, the chitosan mix homogeneously of last and same weight and fineness promptly gets the hemostasis powder dressing of argentiferous Zn composition.
Embodiment 20: the preparation of the hemostasis powder dressing of argentiferous Zn composition.
1 kilogram of zeolite is crossed 200 mesh sieves, join compositions (the parts by weight silver: zinc=1: 1) in the liquid of 5 kilograms of argentiferous zinc of embodiment 2 preparations then, mix and stirred 1 hour, washing more after filtration,, filtration, dry down less than 60 ℃, be crushed to 1200 orders again, the alginate mix homogeneously of last and same weight and fineness promptly gets the hemostasis powder dressing of argentiferous Zn composition.
Embodiment 21: the preparation of the hemostasis powder dressing of argentiferous Zn composition.
100 gram silver peroxides are crossed 200 mesh sieves, with 120 gram malic acid zinc, 200 gram polyacrylic acid, 200 gram carboxymethyl starch mixings, be crushed to 1200 orders more then, promptly get the hemostasis powder dressing of argentiferous Zn composition.
Embodiment 22: the preparation of the hemostasis powder dressing of argentiferous Zn composition.
100 gram silver oxide are crossed 200 mesh sieves, with 50 gram zinc citrates, 200 gram hydroxyethyl-celluloses, 200 gram sodium alginate mixings, be crushed to 1200 orders more then, promptly get the hemostasis powder dressing of argentiferous Zn composition.
Adopt the wound dressing of above-mentioned argentiferous Zn composition, tame rabbit muscle hemostasis is tested, its haemostatic effect is as shown in table 4.
Table 4:
| The dressing kind | Average bleeding stopping period (s) |
| With natural fiber or its yarn fabric, non-woven fabrics is the wound dressing (embodiment 1) of the argentiferous Zn composition of carrier | 69 |
| With chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics is the argentiferous zinc combination of carrier | 46 |
| The wound dressing of thing (embodiment 2) | |
| With alginate fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 3) of the argentiferous Zn composition of carrier | 45 |
| With chitosan fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 4) of the argentiferous Zn composition of carrier | 40 |
| With alginate fiber or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 5) of the argentiferous Zn composition of carrier | 35 |
| With NACF or its woven fabric, knitted fabric, non-woven fabrics is the wound dressing (embodiment 6) of the argentiferous Zn composition of carrier | 48 |
| With NACF and woven fabric thereof, knitted fabric, non-woven fabrics is the wound dressing (embodiment 7) of the argentiferous Zn composition of carrier | 53 |
| With the active carbon powder is the wound dressing (embodiment 8) of the argentiferous Zn composition of carrier | 46 |
| With the polyurethane foam plastics is the wound dressing (embodiment 14) of the argentiferous Zn composition of carrier | 51 |
| With the polyethylene foams is the wound dressing (embodiment 15) of the argentiferous Zn composition of carrier | 49 |
| With the polystyrene foam plastics is the wound dressing (embodiment 16) of the argentiferous Zn composition of carrier | 47 |
| The bentonite powder bleeding-stopping dressing (embodiment 17) of argentiferous Zn composition | 35 |
| The bentonite powder bleeding-stopping dressing (embodiment 18) of argentiferous Zn composition | 38 |
| The zeolite powder bleeding-stopping dressing of argentiferous Zn composition (embodiment 19) | 35 |
| The zeolite powder bleeding-stopping dressing of argentiferous Zn composition (embodiment 20) | 31 |
| The polyacrylic acid of argentiferous Zn composition, carboxymethyl starch hemostasis powder dressing (embodiment 21) | 30 |
| The hydroxyethyl-cellulose of argentiferous Zn composition, sodium alginate hemostasis powder dressing (embodiment 22) | 31 |
Embodiment 23: the preparation of the gel wound dressing of argentiferous Zn composition.
Following ingredients is mixed the gel wound dressing that obtains the argentiferous Zn composition with conventional method.
Silver peroxide 1.0g
Malic acid zinc 0.5g
Polyethylene Glycol 60.0g
Sodium carboxymethyl cellulose 35.0g
Methyl hydroxybenzoate 0.4g
Nipasol 0.1g
Add pure water to 1000.0g
Mentioned component is mixed fill behind the mixing.
Embodiment 24: the preparation of the gel wound dressing of argentiferous Zn composition.
Following ingredients is mixed the gel wound dressing that obtains the argentiferous Zn composition with conventional method.
Silver oxide 1.0g
Zinc citrate 2.0g
Polyethylene Glycol 40.0g
Carbomer 30.0g
Sodium carboxymethyl cellulose 20.0g
Nipasol 0.1g
Add pure water to 1000.0g
Mentioned component is mixed fill behind the mixing.
Embodiment 25: the preparation of the gel wound dressing of argentiferous Zn composition.
Following ingredients is mixed the gel wound dressing that obtains the argentiferous Zn composition with conventional method.
The prepared argentiferous of embodiment 2, compositions (the parts by weight silver: liquid 50ml zinc=1: 1) of zinc
Polyethylene Glycol 65.0g
Sodium carboxymethyl cellulose 45.0g
Oleum menthae 2.0ml
Nipasol 0.1g
Add pure water to 1000.0g
Mentioned component is mixed fill behind the mixing.
Embodiment 26: the clinical trial of shallow II degree and deep ii degree burn wound surface is treated in the wound dressing of argentiferous Zn composition.
Select each 36 example of shallow II degree and deep ii degree burn wound surface patient, adopt the method for the wound dressing of local application argentiferous Zn composition to carry out clinical trial.The experimental group wound surface adopts the gel dressing of the prepared argentiferous Zn composition of embodiment 23,34,25, outerly wraps up with common gauze; The matched group wound surface adopts the outer burn ointment monolayer petrolatum oil gauze that is coated with to cover, and adds the common gauze wrapping of multilamellar.Clinical test results shows that the wound dressing of argentiferous Zn composition has the effect of significant promotion wound healing.Clinical trial experimental group and matched group wound healing situation see Table 5.
Table 5 clinical trial experimental group and matched group wound healing situation
Claims (9)
1. the wound dressing of an argentiferous Zn composition is made up of the combination material of the argentiferous that adheres on carrier and the carrier, zinc composition, it is characterized in that, the combination material of described argentiferous, zinc composition comprises following composition: H4Ag
2O
6At least a and zinc salt in solution and the silver peroxide; Wherein silver is silver with the ratio of weight and number of zinc: zinc=1: 0.01～100.
2. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 1 is characterized in that: described zinc salt is selected from one or more in zinc sulfate, zinc nitrate, zinc acetate, zinc lactate, zinc gluconate, ethylenediaminetetraacetic acid zinc, malic acid zinc or the zinc citrate.
3. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 1 is characterized in that: described carrier is selected from a kind of in macromolecular material, inorganic mineral or the active carbon.
4. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 3, it is characterized in that: described macromolecular material is selected from natural fiber and yarn fabric thereof, non-woven fabrics, foam plastics, the chitosan fiber powder, granule and woven fabric thereof, knitted fabric, non-woven fabrics or collagen fiber powder, granule and woven fabric thereof, knitted fabric, non-woven fabrics or alginic acid fibre powder, granule and woven fabric thereof, knitted fabric, non-woven fabrics, viscose glue, polypropylene and polypropylene fibre, polyethylene, polyurethane fibre, aramid fiber, poly-acetate, polyacrylic acid, polyacrylic acid amide, acrylic acid and acrylamide copolymer, polyurethane and polyurethane fiber, polyvinyl alcohol, polyvinyl alcohol and anhydride cross-linking agent, polyvinyl alcohol and acrylic acid graft copolymer, vinyl acetate and acrylate copolymerization hydrolysate, Polyethylene Glycol, polyvinylpyrrolidone, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, the fibre grafting acrylates, fibre grafting acrylate, cellulose xanthogenation grafted propylene hydrochlorate, carbomer, hydroxyethyl-cellulose, arabic gum, corn starch, starch graft acrylamide, starch grafted acrylate, starch-grafted propylene fat, HANSHENGJIAO, lac, sodium alginate, gelatin, pectin, xanthan gum, collagen protein, hyaluronic acid, somatomedin, heparin, chondroitin sulfate or carboxymethyl starch.
5. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 4 is characterized in that: described foam plastics is RPUF, flexible polyurethane foam, polystyrene foam plastics or polyethylene foams.
6. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 3 is characterized in that: described inorganic mineral is selected from one or more in graphite, bentonite, Kaolin, zeolite, Montmorillonitum, meerschaum, Gypsum Fibrosum, white carbon, quartz sand, attapulgite, kieselguhr or the chalky soil.
7. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 3 is characterized in that: described active carbon is woven fabric, knitted fabric, non-woven fabrics and the activated carbon felt of active carbon powder, granule or NACF.
8. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 1 is characterized in that: the combination material of described argentiferous, zinc composition is attached on the described carrier with the method for dipping, coating, spraying, absorption.
9. the wound dressing of a kind of argentiferous Zn composition as claimed in claim 1 is characterized in that: the dosage form of the wound dressing of described argentiferous Zn composition is applicator material, membrane, gel, dried glue granule, spray, liniment and powder agent.
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Effective date of registration: 20150909 Address after: 518000 Guangdong city of Shenzhen province Nanshan District high tech Industrial Park, North Central Avenue, North Song Ping Road No. 1 Lite technology building south 10 layer 1001 Patentee after: SHENZHEN YUANXING NANO PHARMACEUTICAL TECHNOLOGY CO.,LTD. Address before: 100081, Beijing, Zhongguancun Haidian District South Street, No. 12, Huan Tai Building, room 808, room 8 Patentee before: BIO-PHARM SCIENCE & TECHNOLOGY Co.,Ltd. |
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Address after: 518000 Nanshan High-tech Industrial Park, Shenzhen City, Guangdong Province, No. 1 North Songpingshan Road, North Ring Road, No. 10 Floor 001, South Block of Yuanxing Science and Technology Building Patentee after: SHENZHEN YUANXING PHARMACEUTICAL CO.,LTD. Address before: 518000 Nanshan High-tech Industrial Park, Shenzhen City, Guangdong Province, No. 1 North Songpingshan Road, North Ring Road, No. 10 Floor 001, South Block of Yuanxing Science and Technology Building Patentee before: SHENZHEN YUANXING NANO PHARMACEUTICAL TECHNOLOGY CO.,LTD. |
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