CN1709385A - Chinese medicine external-application oil agent for treating skin and external disease - Google Patents
Chinese medicine external-application oil agent for treating skin and external disease Download PDFInfo
- Publication number
- CN1709385A CN1709385A CNA2005100428161A CN200510042816A CN1709385A CN 1709385 A CN1709385 A CN 1709385A CN A2005100428161 A CNA2005100428161 A CN A2005100428161A CN 200510042816 A CN200510042816 A CN 200510042816A CN 1709385 A CN1709385 A CN 1709385A
- Authority
- CN
- China
- Prior art keywords
- group
- parts
- present
- radix
- external
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to a Chinese medicine oil solution preparation for external application for curing skin and external diseases with obvious therapeutic effect. Said oil solution preparation for external application is made up by using (by weight portion) 10 portions of puccoon, 48 portions of lonicera stem and leaf, 15 portions of borneol, 2 portions of pearl and 42 portions of Chinese angelica root through conventional preparation process.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly a kind of Chinese medicine external-use oil preparation that is used for the treatment of skin swelling and ulcer.
Background technology
Skin swelling and ulcer comprises diseases such as skin wound infection, skin infection ulceration, is the common frequently-occurring disease of surgical clinical, and men and women, old and young all can suffer from, and it not only brings very big misery to the patient, also has a strong impact on its physical and mental health and work, life.Chinese patent gazette disclosed the name of being declared by the applicant to be called " a kind of Chinese medicine external-use oil preparation that is used for the treatment of skin swelling and ulcer ", publication number was 1470254 patent application on January 28th, 2004, and each raw material components and the proportioning value that constitute this oil preparation are: 5～50 unit of weights of Radix Arnebiae (Radix Lithospermi), 30～150 unit of weights of Caulis Lonicerae, 2～10 unit of weights of Margarita, 30～150 unit of weights of Radix Angelicae Sinensis, 10～150 unit of weights of Borneolum Syntheticum, 1000～3000 unit of weights of Oleum Sesami.But we find that the effect of this Chinese patent medicine is desirable not enough in actual application.In nearly 2 years time, we grope by a large amount of experiments on original basis, found best set of dispense ratio, and technology have been made external-use oil preparation routinely, and clinical pharmacodynamic experiment proves that its effect is more remarkable,
Summary of the invention
The objective of the invention is to: the Chinese medicine external-use oil preparation that provides a kind of curative effect to treat skin swelling and ulcer more significantly.
The present invention is achieved in that according to components by weight percent and calculates that external-use oil preparation of the present invention is to be prepared from by following materials of weight proportions medicine, wherein: 10 parts of Radix Arnebiae (Radix Lithospermi)s, 48 parts of Caulis Loniceraes, 15 parts of Borneolum Syntheticums, 2 parts of Margaritas, 42 parts of Radix Angelicae Sinensis.
External-use oil preparation of the present invention can prepare like this: Borneolum Syntheticum is ground into fine powder, and Margarita powder is broken into fine powder, and is standby; Radix Arnebiae (Radix Lithospermi), Caulis Lonicerae and Radix Angelicae Sinensis add Oleum Sesami in 100 ℃ of extraction secondaries, and extraction time is 1 hour for the first time, is 10 minutes for the second time, filters, and merging filtrate adds above-mentioned medicated powder, and adds Oleum Sesami to 1000ml, mixing, and packing, promptly.
Pharmacodynamic test of active extract proves: 42 parts of 10 parts of raw material weight proportioning Radix Arnebiae (Radix Lithospermi)s, 48 parts of Caulis Loniceraes, 15 parts of Borneolum Syntheticums, 2 parts of Margaritas, Radix Angelicae Sinensis are with former invention weight proportion 11: 5 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Caulis Loniceraes, 2 parts of Margaritas, 30 parts of Radix Angelicae Sinensis, 10 parts of Borneolum Syntheticums and former invention weight proportion 2: 50 parts of Radix Arnebiae (Radix Lithospermi)s, 150 parts of Caulis Loniceraes, 10 parts of Margaritas, 150 parts of Radix Angelicae Sinensis, Borneolum Syntheticum are compared for 150 parts, and results of pharmacodynamic test is significantly increased.
Pharmacodynamic test of active extract
One, purpose: contrast former invention pharmaceutical composition, observe the present invention to the influence of the damaging non-infectious union of wounded skin of Cavia porcellus, to intersect dish cause the influence of rat paw edema, to the influence of rat paw edema due to the Ovum Gallus domesticus album.
Two, method: utilize shears to cause the damaging non-infectious skin wound of Cavia porcellus, observe former invention pharmaceutical composition and the present invention preventive and therapeutic effect to the damaging non-infectious union of wounded skin of Cavia porcellus; Utilize intersection dish, Ovum Gallus domesticus album to make proinflammatory agent, observe former invention pharmaceutical composition and the present invention preventive and therapeutic effect rat paw edema.The result: the three can promote that all shears causes the healing of the damaging non-infectious skin wound of Cavia porcellus, to intersect dish, Ovum Gallus domesticus album causes rat paw edema that tangible preventive effect is arranged, the present invention obviously is better than former invention pharmaceutical composition.Illustrate that the present invention can promote obviously that shears causes the healing of the damaging non-infectious skin wound of Cavia porcellus, to intersect dish, Ovum Gallus domesticus album causes rat paw edema that tangible preventive effect is arranged.
1 material and method
1.1 animal, Cavia porcellus, male, 266 ± 32g; The Wistar rat, male, body weight 160-180g: rabbit, male and female half and half, 1.898 ± 0.129kg.
1.2 medicine
1, of the present invention group: Borneolum Syntheticum 15g is ground into fine powder, and Margarita 2g is ground into fine powder, and is standby; Radix Arnebiae (Radix Lithospermi) 10g, Caulis Lonicerae 48g and Radix Angelicae Sinensis 42g add Oleum Sesami in 100 ℃ of extraction secondaries, and extraction time is 1 hour for the first time, is 10 minutes for the second time, filters, and merging filtrate adds above-mentioned medicated powder, and adds Oleum Sesami to 1000ml, and mixing makes.(by 10 parts of Radix Arnebiae (Radix Lithospermi)s of the present invention, 48 parts of Caulis Loniceraes, 15 parts of Borneolum Syntheticums, 2 parts of Margaritas, 42 parts of proportionings of Radix Angelicae Sinensis)
2, former invention is 1 group: earlier Borneolum Syntheticum 10g, Margarita 2g are pulverized (the former becomes fine powder, and the latter becomes fine powder), Radix Arnebiae (Radix Lithospermi) 5g, Caulis Lonicerae 30g and Radix Angelicae Sinensis 30g are inserted in 100 ℃ of Oleum Sesami of 1000g again, heating 60min filters, and gets Borneolum Syntheticum and Pearl then and adds in the filtrate, stir evenly, promptly.(by former invention weight proportion 1: 5 parts of Radix Arnebiae (Radix Lithospermi)s, 30 parts of Caulis Loniceraes, 2 parts of Margaritas, 30 parts of Radix Angelicae Sinensis, 10 parts of Borneolum Syntheticums, 1000 parts of proportionings of Oleum Sesami)
3, former invention is 2 groups: earlier Borneolum Syntheticum 150g, Margarita 10g are pulverized (the former becomes fine powder, and the latter becomes fine powder), Radix Arnebiae (Radix Lithospermi) 50g, Caulis Lonicerae 150g and Radix Angelicae Sinensis 150g are inserted in the 3000g100 ℃ of Oleum Sesami again, heating 60min filters, and gets Borneolum Syntheticum and Pearl then and adds in the filtrate, stir evenly, promptly.(by former invention weight proportion 2: 50 parts of Radix Arnebiae (Radix Lithospermi)s, 150 parts of Caulis Loniceraes, 10 parts of Margaritas, 150 parts of Radix Angelicae Sinensis, 150 parts of Borneolum Syntheticums, 3000 parts of proportionings of Oleum Sesami)
1.3.1 influence to the damaging non-infectious union of wounded skin of Cavia porcellus
Get 50 of male guinea pigs, be divided into 5 groups immediately, every group 10, Oleum Sesami group, libano group (2mg/kg), former invention 1 group of (200mg/kg), former invention 2 groups of (200mg/kg), of the present invention group (200mg/kg), cut a kerf in the depilation district center with shears, major diameter 7.93 ± 1.27mm, after 24 hours, the beginning administration.Left side: give normal saline; Right side: be subjected to reagent, cover with one deck oilpaper and two-layer gauze, fixing with non-stimulated adhesive plaster sealing again, continue 6 hours, once a day, continuous 15 days, (criterion of cure was the healing state of wound: cicatrization after the observation drug of topical application, wound surface is grown flat substantially), dwindle percent with wound before and after the administration and respectively organize difference.See Table 1
Table 1 the present invention is to the influence of the damaging non-infectious union of wounded skin of Cavia porcellus (X ± SD)
| Group | The example number | Before the administration | After the administration | Minification (%) |
| 2 groups of the present invention group of 1 group of former invention of the former invention of Oleum Sesami libano | ??10 ??10 ??10 ??10 ??10 | ??8.1±2.2 ??8.0±1.9 ??8.3±1.7 ??7.9±2.0 ??8.2±1.7 | ??2.6±1.9 ??1.5±1.8 ??2.2±2.0 ??1.8±1.9 ??1.2±1.3 * | ??67.54 ??81.38 ??73.22 ??76.84 ??84.91 * |
Annotate: with the Oleum Sesami group relatively, 1. 2. p＜0.01, p＜0.05
Show by experimentation the damaging non-infectious union of wounded skin influence of Cavia porcellus, compare with the Oleum Sesami group, of the present invention group of process statistical procedures has significant difference (p＜0.05), though and 1 group of former invention, former invention slightly improve for 2 groups, but learn processing more by statistics with the Oleum Sesami group, and there was no significant difference, illustrate that both improve degree to the damaging non-infectious skin peptide wound healing of Cavia porcellus and all organize not as good as A.
1.3.2 the intersection dish is caused the influence of rat paw edema
Get 50 of Wistar rats, be divided into 5 groups immediately, every group 10, Oleum Sesami group, WUJI GAO group (1g/kg), former invention 1 group of (200mg/kg), former invention 2 groups of (200mg/kg), of the present invention group (200mg/kg) respectively organize the right back sufficient normal volume of rat (ml) by micro-capillary tube method mensuration before the experiment.Cause and evenly be coated with the different reagents that is subjected in right back sufficient sole of the foot portion before scorching, the blank group gives the Oleum Sesami of equal volume, only intersect dish 0.1ml/ in the subcutaneous injection 1% of the right back sufficient sole of the foot portion of rat after one hour, simultaneously respectively organize again coating once, mensuration causes the right back sufficient volume of inflammation back 1h, 2h, 4h, 6h, so that the difference of right back sufficient volume is the swelling degree before and after scorching, respectively organizes swelling degree difference.The results are shown in Table 2
Table 2 the present invention causes the influence (X ± SD) of rat paw edema to intersecting dish
| Group | The example number | ??1h | ??2h | ??4h | ??6h |
| 2 groups of the present invention group of 1 group of former invention of the former invention of Oleum Sesami WUJI GAO group | ??10 ??10 ??10 ??10 ??10 | ??0.17±0.07 ??0.09±0.05* ??0.17±0.08 ??0.16±0.05 ??0.15±0.07 | ??0.28±0.12 ??0.12±0.05** ??0.18±0.06* ??0.20±0.07* ??0.14±0.06** | ??0.31±0.13 ??0.10±0.08** ??0.17±0.07* ??0.26±0.09 ??0.12±0.08** | ??0.31±0.20 ??0.06±0.07** ??0.14±0.05* ??0.08±0.10** ??0.06±0.04** |
Compare * p＜0.05, * * p＜0.01 with matched group
The result shows, with matched group relatively, 2 groups, of the present invention group of 1 group of former invention, former invention cause rat paw edema in various degree inhibitory action are all arranged intersecting dish.And action intensity of the present invention is greater than the action intensity of 2 groups of 1 group of former invention and former inventions.
1.3.3 influence to rat paw edema due to the Ovum Gallus domesticus album
Get 50 of rats, be divided into 5 groups at random, every group 10, be respectively: (1) blank group: distilled water 1ml/100g body weight, prednisone acetate tablets group (10mg/kg), former invention 1 group of (200mg/kg), former invention 2 groups of (200mg/kg), of the present invention group (200mg/kg), each is organized before the administration earlier will the standardized clear horizontal line in upper end, every the right back ankle of rat joint (noting consistent as far as possible apart from the height of ankle) with marking pen, with the normal foot sole of the foot volume of the sufficient sole of the foot volume below the sufficient volumetric method measurement rat hindleg horizontal line labelling as this Mus.After measuring the right back sufficient sole of the foot normal volume of each rat, use different medicines by above-mentioned group.After administration, only cause inflammation from the right back sufficient plantar subcutaneous injection 20% fresh Ovum Gallus domesticus album normal saline solution 0.1ml/ of rat in 1 hour and cause pedal swelling.Cause scorching back 0.5,1,2,3,4,5 and 6 hour at the injection Ovum Gallus domesticus album, measure the volume of the right back sufficient sole of the foot of each rat respectively.So that the difference of the volume of rat paw is as swelling degree of the paw (ml) before and after scorching.Test bit is handled with statistics (t check).And by following formula calculating inflammation suppression ratio.
Result of the test sees Table 3.
Table 3 the present invention is to the influence of rat paw edema due to the Ovum Gallus domesticus album
| Group | Number of animals (only) | The rat paw edema degree of different time after causing inflammation (X ± S, ml) | ||||||
| ??0.5h | ??1h | ??2h | ??3h | ??4h | ??5h | ??6h | ||
| 2 groups of prednisone groups of 1 group of former invention of of the present invention group of former invention of blank group | ??10 ?? ??10 ??10 ? ??10 ? ??10 | ??0.65 ??±0.17 ??0.32 **??±0.24 ??(50.77％) ??0.58 ??±0.24 ??(10.77％) ??0.49 ??±0.20 ??(24.62％) ??0.55 ??±0.28 ??(15.38％) | ??0.85 ??±0.26 ??0.48 **??±0.20 ??(43.28％) ??0.70 ??±0.32 ??(17.65％) ??0.69 ??±0.23 ??(18.82％) ??0.55 *??±0.28 ??(35.29％) | ??0.67 ??±0.26 ??0.38 **??±0.20 ??(43.28％) ??0.66 ??±0.26 ??(1.49％) ??0.40 *??±0.20 ??(40.30％) ??0.36 **??±0.19 ??(46.27％) | ??0.53 ??±0.16 ??0.28 *??±0.20 ??(47.17％) ??0.38 ??±0.27 ??(28.30％) ??0.39 ??±0.23 ??(26.42％) ??0.28 **??±0.26 ??(47.17％) | ??0.41 ??±0.12 ??0.20 **??±0.16 ??(51.22％) ??0.16 **??±0.15 ??(60.98％) ??0.19 **??±0.19 ??(5366％) ??0.15 **??±0.18 ??(63.41％) | ??0.35 ??±0.18 ??0.12 **??±0.20 ??(65.71％) ??0.09 ??±0.16 ??(74.29％) ??0.14 ??±0.15 ??(60.00％) ??0.08 **??±0.14 ??(77.14％) | ??0.15 ??±0.16 ??0.09 **??±0.16 ??(40.00％) ??0.06 ??±0.14 ??(60.00％) ??0.09 ??±0.06 ??(40.84％) ??0.05 ??±0.11 ??(66.67％) |
Annotate: (1) compares * P＜0.05, * * P＜0.01 with the blank group
(2) numerical value is and blank group inhibition percentage rate relatively in the bracket.
As seen from Table 3, after of the present invention group of administration, rat paw edema due to the Ovum Gallus domesticus album is had significant inhibitory effect, and onset is very fast, the persistent period is also longer.After administration the suppression ratio of 1.5～6 hours (promptly cause scorching back 0.5,1,2,3,4,5 hour) be respectively 50.77%, 43.28%, 43.28%, 47.17%, 51.22% and 65.71%.P all＜0.05～0.01.1 group of former invention is causing scorching back 4 hours, and 2 groups of former inventions also had remarkable inhibitory action in 2,4 hours causing scorching back, and suppression ratio is respectively 60.98%, 40.30% and 53.66%, and P all＜0.05～0.01.Show that 1 group of former invention, 2 groups of former inventions, the present invention all have antiinflammatory action to rat paw edema (acute exudative inflammation) due to the Ovum Gallus domesticus album, but of the present invention group of effect is better, and acting duration is obviously than 1 group of former invention, former invention 2 group leaders.
1.3.4 the present invention is to the pharmacodynamic study of rabbit skin infection
Get 60 of rabbit, be divided into 6 groups at random, every group 10, be respectively the normal saline group, the Oleum Sesami group, gentamycin group (50 μ g/ml), of the present invention group (200mg/kg), 1 group of the present invention (200mg/kg), 2 groups of the present invention (200mg/kg), after every rabbit left and right sides back sterilized respectively with iodine tincture and 75% ethanol, by sterile working's step, cut the skin of 15 millimeters of skin diameters respectively, totally 5 place's wounds. with staphylococcus aureus 9421 infectious bacteria liquid (its concentration is equivalent to 107cfu/ml) infected wound, every wound infection 0.1ml of place, for bacterium liquid contacts the enough time with wound, cover on wound with kpetrolatum gauze, what will weave simultaneously seals the wire gauze medicated cap with all-purpose adhesive cloth, be bonded at wound circumference skin place with all-purpose adhesive, to keep wound moistening, the experimental rabbit cervical region is fixed with special circular aluminium gold clamping, makes mouth can't bait gauze cap and gauze can normally carry out so that test.Wound begins coating after infecting 24 hours, once a day, successive administration 9 days is used the cotton swab normal saline before administration every day, and sassafras bathes a wound, the kpetrolatum gauze that more renews after the administration.Experiment back rabbit is respectively organized wound diameter and sees Table 4, and count of bacteria the results are shown in Table 5 before and after the administration.
Wound diameter variation after table 4 drug withdrawal (X ± SD)
| Group | The example number | The wound meansigma methods |
| 1 group of 1 group of the present invention of of the present invention group of the present invention of normal saline Oleum Sesami gentamycin | ??10 ??10 ??10 ??10 ??10 ??10 | ??11.18±1.43 ??11.47±1.99 ??5.41±1.14 (2)??5.78±1.29 (2)??6.41±1.27 (2)(4)??8.47±1.35 (2)(4) |
Annotate: with the normal saline group relatively, 1. 2. p＜0.01, p＜0.05, with of the present invention group relatively, 3. 4. p＜0.01, p＜0.05
By observe respectively organize the rabbit drug withdrawal after the wound diameter result of variations show, each group of the present invention compares with the normal saline group, through statistical procedures significant difference is arranged all, of the present invention group of influence degree to wound diameter all is better than 1 group of the present invention, 2 groups of the present invention (p＜0.01).
Antibacterial variation before and after table 5 administration (X ± SD)
| Group | The example number | Before the administration | After the administration |
| 2 groups of 1 group of the present invention of of the present invention group of the present invention of normal saline Oleum Sesami gentamycin | ??10 ??10 ??10 ??10 ??10 ??10 | ??3.71±0.30 ??3.62±0.33 ??3.68±0.32 ??3.72±0.36 ??3.64±0.29 ??3.74±0.32 | ??2.60±0.19 ??2.68±0.34 ??0.18±0.16 (2)??0.92±0.45 (2)??1.29±0.23 (2)(4)??2.02±0.38 (1)(4) |
Annotate: with the normal saline group relatively, 1. 2. p＜0.01, p＜0.05, with of the present invention group relatively, 3. 4. p＜0.01, p＜0.05
Respectively organize rabbit antibacterial result of variations by observation and show, antibacterial all had significant change before and after each organized the rabbit administration, and the gentamycin group obviously is better than other each groups (p＜0.01), and of the present invention group obviously is better than 1 group of the present invention, 2 groups of the present invention (p＜0.01) again.
Claims (2)
1, a kind of Chinese medicine external-use oil preparation that is used for the treatment of skin swelling and ulcer is characterized in that each raw material components and proportioning value are:
10 parts of Radix Arnebiae (Radix Lithospermi)s, 48 parts of Caulis Loniceraes, 15 parts of Borneolum Syntheticums, 2 parts of Margaritas, 42 parts of Radix Angelicae Sinensis.
2, the preparation method of the Chinese medicine external-use oil preparation of treatment skin swelling and ulcer as claimed in claim 1, it is characterized in that: Borneolum Syntheticum is ground into fine powder, and Margarita powder is broken into fine powder, and is standby; Radix Arnebiae (Radix Lithospermi), Caulis Lonicerae and Radix Angelicae Sinensis add Oleum Sesami in 100 ℃ of extraction secondaries, and extraction time is 1 hour for the first time, is 10 minutes for the second time, filters, and merging filtrate adds above-mentioned medicated powder, and adds Oleum Sesami to 1000ml, mixing, and packing, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100428161A CN100336518C (en) | 2005-06-15 | 2005-06-15 | Chinese medicine external-application oil agent for treating skin and external disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100428161A CN100336518C (en) | 2005-06-15 | 2005-06-15 | Chinese medicine external-application oil agent for treating skin and external disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1709385A true CN1709385A (en) | 2005-12-21 |
| CN100336518C CN100336518C (en) | 2007-09-12 |
Family
ID=35705717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100428161A Active CN100336518C (en) | 2005-06-15 | 2005-06-15 | Chinese medicine external-application oil agent for treating skin and external disease |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100336518C (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1232269C (en) * | 2002-07-25 | 2005-12-21 | 咸阳步长医药科技发展有限公司 | Chinese medicinal external-use oil preparation for treating skin swelling and ulcer |
-
2005
- 2005-06-15 CN CNB2005100428161A patent/CN100336518C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN100336518C (en) | 2007-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106334067B (en) | Gynecological gel containing silver ion antibacterial agent, preparation method and application | |
| Pena | Melaleuca Alternifolia oil its use for Trichomonal vaginitis and other vaginal infections | |
| CA2820403C (en) | Multipurpose gel for vaginal dryness with direct and delayed effect | |
| CN110604810A (en) | Hydrolyzed collagen gel for gynecology and preparation method thereof | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN103656111A (en) | Internal traditional Chinese medicine preparation for preventing and treating diabetic foot and preparation method thereof | |
| Hanafiah et al. | The effect of 3% binahong leaf extract gel on the wound healing process of post tooth extraction | |
| CN108404111A (en) | One kind is with kidney bean phytolectin inhibitory anti-virus preparation as main component | |
| CN112245325A (en) | Health-care antibacterial gel and preparation method thereof | |
| CN104474536A (en) | Fresh agrimonia pilosa medicine preparation for treating wounds | |
| CN100336518C (en) | Chinese medicine external-application oil agent for treating skin and external disease | |
| CN103479817A (en) | Wound healing gel | |
| CN106237029B (en) | A kind of aloe antibiotic gel and preparation method thereof | |
| CN1112003A (en) | Health sticker for lactation | |
| CN102697925A (en) | Traditional Chinese medicine combination for treating aural eczema | |
| CN1068785C (en) | Chinese patent medicine for external application for curing diseases of scald, burn and dermal ulcer | |
| CN1244351C (en) | Compound powder peparation for curing gynecopathy, its preparation method and application | |
| CN103239594B (en) | Topical pharmaceutical composition for preventing and treating canine acariasis disease and preparation method thereof | |
| CN1186068C (en) | Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process | |
| CN1239172C (en) | Oil from trees | |
| Sonekar et al. | Clinical evaluation of panchavalkal kashay dhavan In the management of diabetic wound | |
| CN100356930C (en) | External-use powder for treating swelling anducler and actue-chronic osteomyelitis | |
| CN102000282B (en) | Pure traditional Chinese medicine paster for treating recurrent oral ulcer and preparation method thereof | |
| RU2432961C1 (en) | Medication for vaginal application, possessing contraceptive and protective against infectious diseases action | |
| CN1050758C (en) | Traditional Chinese medicine sterilizing agent and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: BAODING BUCHANG TIANHAO PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: BUCHANG MEDICAL SCIENCE + TECHNOLOGY DEVELOPING CO., LTD., XIANYANG CITY Effective date: 20100108 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20100108 Address after: Hebei Dingxing 86188 army hospital Patentee after: Baoding Buchang Tianhao Pharmaceutical Co., Ltd. Address before: Shaanxi city of Xi'an province high tech high road No. 50 Nanyang International Building, 20 floor Patentee before: Buchang Medical & Drug Science & Tech. Development Co., Ltd., Xianyang |
|
| C56 | Change in the name or address of the patentee |
Owner name: BAODING TIANHAO PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: BAODING BUCHANG TIANHAO PHARMACEUTICAL CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: Xinghua 072650 Hebei province Dingxing County Road No. 128 Patentee after: BAODING TIANHAO PHARMACEUTICAL CO., LTD. Address before: 072650 Hebei province Dingxing County 86188 army hospital Patentee before: Baoding Buchang Tianhao Pharmaceutical Co., Ltd. |