CN1660260A - Effervescence grains of reducing fever and relieving a cough for infant and preparation method - Google Patents

Abstract

A Chinese medicine in the form of effervescent particles for treating infantile cold and cough is prepared from auxiliary and 7 Chinese-medicinal materials including ephedra, bitter apricot kernel, gypsum, liquorice root. Its preparing process is also disclosed.

Description

Infantile heat-clearing and antitussive effervescent granule and method for making thereof

Technical field

The invention belongs to a kind of is the medicine of preparation of raw material with the Chinese herbal medicine, particularly belongs to the effervescent granule of heat clearing away and cough-relieving.

Background technology

Fever caused by exogenous pathogens is the symptom of common respiratory tract disease, is common in pediatric patient.Fever caused by exogenous pathogens can influence patient's life and normal development.China has accumulated rich experience over thousands of years aspect treatment infantile fever caused by exogenous pathogens disease, and traditional traditional Chinese medical science and herbalist have many prescriptions.Commercially available " infantile heat-clearing and antitussive oral liquid " is exactly one of them kind.Some be used for the application of antipyretic Chinese herbal medicine formula patent of invention, for example No. 95106240.9 " Antifebrile oral liquor ", No. 00121310.5 " a kind of antipyretic and preparation method thereof ", No. 02159199.7 " a kind of children's antipyretic medicines " etc. are arranged in recent years.

The medicament of above-mentioned all treatment fever caused by exogenous pathogens all has certain effect.But doctors are still exploring better prescription, to alleviate the patient suffering as early as possible, to recover patient health.

Summary of the invention

It is the clearing and antitussive effervescent granule that raw material is made that purpose of the present invention just is to provide a kind of Chinese medicine that adopts, and makes the pediatric patient can be in shorter time, and symptom is alleviated and disappeared.

Solution of the present invention is based on commercially available " infantile heat-clearing and antitussive oral liquid ", with reference to inventor's medical practice experience, takes the novel form of release for making things convenient for pediatric patient.

Infantile heat-clearing and antitussive effervescent granule of the present invention is made by crude drug and adjuvant, and wherein the component of crude drug and consumption thereof (consumption is a weight portion) are as follows:

Herba Ephedrae 90 Semen Armeniacae Amarums 120 Gypsum Fibrosum 270 Radix Glycyrrhizaes 90 Radix Scutellariaes 180 Radix Isatidis 180

Rhizoma Menispermi 90

The quality proportioning of the mixture of said medicine and adjuvant is:

Medicinal mixture 5%～80%,

Adjuvant 20%～95%

Adjuvant wherein can be an acidic excipient, comprises citric acid, tartaric acid, sodium dihydrogen phosphate, Sodium Acid Pyrophosphate, sodium sulfite etc., and basic auxiliary, comprises sodium bicarbonate, sodium carbonate, potassium bicarbonate, sodium glycine carbonate, sodium sesquicarbonate etc.; Also need add filler soluble starch, cane sugar powder.

The quality proportioning of used acidic excipient and basic auxiliary is:

Acidic excipient 40%～50%

Basic auxiliary 50%～60%.

In the said herbal medicine, Herba Ephedrae (Ephedra sinica), warm in nature, acrid in the mouth is bitter, diaphoresis is arranged, relieving asthma, the effect of diuretic, cold table reality that can cure the wound, fever with chills, headache nasal obstruction, cough and asthma (seeing 2221 pages of the new medical college volumes in Jiangsu " Chinese medicine voluminous dictionary "); Semen Armeniacae Amarum, i.e. Semen Armeniacae Amarum, warm in nature for the core of the dry seed of rosaceous plant Fructus Pruni (Prunusarmeniaca), bitter in the mouth, poisonous, the effect of expelling phlegm for arresting cough is arranged, relievining asthma can be controlled diseases (seeing " Chinese medicine voluminous dictionary " 1100 pages) such as exogenous cough, dyspnea with fullness of the chest, sore throat; Gypsum Fibrosum (Cypsum), acrid-sweet flavor, cold in nature, the effect that has expelling pathogenic factors from muscles for clearing heat, relieving restlessness to quench the thirst can control that the calentura high fever does not move back, vexed coma, thirsty and dry pharynx, lung-heat dyspnea with rapid respiration (seeing " Chinese medicine voluminous dictionary " 592 pages); Radix Glycyrrhizae (Glycyrrhizauralensis), flat, the sweet in the mouth of property has and middle emergency, lung moistening, antidotal effect, can control laryngopharynx swelling and pain, the lung diseases such as cough (seeing " Chinese medicine voluminous dictionary " 567 pages) of withering; Radix Scutellariae (Scutellaria baicalensis), cold in nature, bitter in the mouth has the effect of heat clearing and damp drying, eliminating fire and detoxication, removing heat from blood heat extraction, can control high fever excessive thirst, cough due to lung-heat, damp-heat dysentery (seeing " Chinese medicine voluminous dictionary " 2017 pages); Radix Isatidis (Isatis tinctoria), cold in nature, bitter in the mouth has the effect of heat clearing away, detoxifcation, removing heat from blood, can control influenza, pneumonia (seeing " Chinese medicine voluminous dictionary " 1250 pages); Rhizoma Menispermi, promptly Radix Sophorae Tonkinensis is the root of leguminous plant root of subprostrate sophora (Sophora subprostrata), bitter in the mouth is cold in nature, relieves inflammation or internal heat, detoxifies, detumescence, analgesic effect, can soothe sore throat, sore throat, dyspnea with fullness of the chest heat syndrome cough see " Chinese medicine voluminous dictionary " 182 pages).

The preparation method of infantile heat-clearing and antitussive effervescent granule of the present invention comprises:

(1) gets the decocting that Herba Ephedrae, Gypsum Fibrosum add 8～12 times in proportion and boil 10～120min, add in proportion again and fry the Semen Armeniacae Amarum of processing and Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis, Rhizoma Menispermi in advance, decocted 1～4 hour; The decocting that adds 6～10 times of doses for the 2nd time boiled 0.5～3 hour, merged decoction liquor;

(2) decoction liquor with above-mentioned merging filters, and filtrate decompression is concentrated into 200～2000ml, leaves standstill after 6～36 hours to filter, and filtrate is condensed into the extractum that density is 1.05～1.35 (50～60 ℃), and is standby;

(3) gained extractum is divided into two parts, gets a acidic excipient and the filler of adding, another part adds basic auxiliary and filler, and then the mixed soft material of difference, granulate oven dry, hybrid particles, granulate, pack promptly makes the infantile heat-clearing and antitussive effervescent granule after the assay was approved.

The preferred processing condition of above method for making is:

The water yield that step (1) adds for the first time is 10 times of dose; Herba Ephedrae and Gypsum Fibrosum decocted 0.5 hour earlier; Add that decocting time is 2.0 hours behind the remaining medicine, amount of water is 8 times of dose for the second time, decocts 1 hour the best;

Step (2) is evaporated to 600ml and is advisable, and leaves standstill 24 hours the bests;

Step (3) acidic excipient selects for use citric acid, basic auxiliary to select for use sodium bicarbonate, filler to add sucrose the best.

Infantile heat-clearing and antitussive effervescent granule usage of the present invention is for oral administration, and the patient obeys 4 every day, and in crude drug, 1 years old with interior each 2.5g; 1～3 year old each 5g; 4～6 years old each 7.5g; 7～14 years old each 10g; Take with the eliminating cold for resuscitation water dissolution.

Infantile heat-clearing and antitussive effervescent granule of the present invention is based on the infantile heat-clearing and antitussive oral liquid, further develops, and it has good heat clearing away, lung qi dispersing, relievings asthma, the sore-throat relieving effect.Be used for diseases such as Sheng, fever with chills, cough expectorant Huang, tachypnea dyspnea with rapid respiration, xerostomia hoarseness, laryngopharynx swelling and pain in children's exogenous, the evil poison clinically.This product is taken safety, effective, convenient, and medicine stability is good.

The specific embodiment

Embodiment prepares the infantile heat-clearing and antitussive effervescent granule by the following method:

(1) gets Herba Ephedrae 90g, Gypsum Fibrosum 270g and add the 3600ml clear water and decoct 10～120min, add again and fry the Semen Armeniacae Amarum 120g that processs and Radix Glycyrrhizae 90g, Radix Scutellariae 180g, Radix Isatidis 180g, Rhizoma Menispermi 90g in advance, decocted 2 hours; The decocting that adds 8 times of doses for the 2nd time boiled 1 hour, merged decoction liquor;

(2) decoction liquor with above-mentioned merging filters, and filtrate decompression is concentrated into 600ml, leaves standstill after 24 hours to filter, and filtrate is condensed into the extractum that density is 1.05～1.35 (50～60 ℃), and is standby;

(3) gained extractum is divided into two parts, get a acidic excipient citric acid 90g of adding and sucrose 350g, another part adds basic auxiliary sodium bicarbonate 108g and sucrose 350g, mixed then soft material is granulated, oven dry, hybrid particles, granulate, pack promptly makes infantile heat-clearing and antitussive effervescent granule 1000g (net weight) after the assay was approved.

Claims (5)

1 infantile heat-clearing and antitussive effervescent granule is made by crude drug and adjuvant, it is characterized in that the component of crude drug and consumption (consumption is a weight portion) thereof are as follows:

Herba Ephedrae 90 Semen Armeniacae Amarums 120 Gypsum Fibrosum 270 Radix Glycyrrhizaes 90 Radix Scutellariaes 180 Radix Isatidis 180

Rhizoma Menispermi 90

The quality proportioning of the mixture of said medicine and adjuvant is:

Medicinal mixture 5%～80%,

Adjuvant 20%～95%.

2 according to the described infantile heat-clearing and antitussive effervescent granule of claim 1, it is characterized in that adjuvant wherein can be an acidic excipient, comprise citric acid, tartaric acid, sodium dihydrogen phosphate, Sodium Acid Pyrophosphate, sodium sulfite etc., and basic auxiliary, comprise sodium bicarbonate, sodium carbonate, potassium bicarbonate, sodium glycine carbonate, sodium sesquicarbonate etc.; Add filler soluble starch, cane sugar powder again.

3 according to claim 1 or 2 described infantile heat-clearing and antitussive effervescent granules, it is characterized in that the quality proportioning of used acidic excipient and basic auxiliary is:

Acidic excipient 40%～50%

Basic auxiliary 50%～60%.

4 according to the bring down a fever method for making of effervescent granule of the described children's Chai Gui of claim 1, and its feature comprises:

(1) gets the decocting that Herba Ephedrae, Gypsum Fibrosum add 8～12 times in proportion and boil 10～120min, add in proportion again and fry the Semen Armeniacae Amarum of processing and Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis, Rhizoma Menispermi in advance, decocted 1～4 hour; The decocting that adds 6～10 times of doses for the 2nd time boiled 0.5～3 hour, merged decoction liquor;

(2) decoction liquor with above-mentioned merging filters, and filtrate decompression is concentrated into 200～2000ml, leaves standstill after 6～36 hours to filter, and filtrate is condensed into the extractum that density is 1.05～1.35 (50～60 ℃), and is standby;

(3) gained extractum is divided into two parts, gets a acidic excipient and the filler of adding, another part adds basic auxiliary and filler, and then the mixed soft material of difference, granulate oven dry, hybrid particles, granulate, pack promptly makes the infantile heat-clearing and antitussive effervescent granule after the assay was approved.

5 method for makings according to the described infantile heat-clearing and antitussive effervescent granule of claim 1 is characterized in that the preferred processing condition of above method for making is:

The water yield that step (1) adds for the first time is 10 times of dose; Herba Ephedrae and Gypsum Fibrosum decocted 0.5 hour earlier; Add that decocting time is 2.0 hours behind the remaining medicine, amount of water is 8 times of dose for the second time, decocts 1 hour the best;

Step (2) is evaporated to 600ml and is advisable, and leaves standstill 24 hours the bests;

Step (3) acidic excipient selects for use citric acid, basic auxiliary to select for use sodium bicarbonate, filler to add sucrose the best.