CN104147229B - A kind of compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type - Google Patents
A kind of compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type Download PDFInfo
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- CN104147229B CN104147229B CN201410422183.6A CN201410422183A CN104147229B CN 104147229 B CN104147229 B CN 104147229B CN 201410422183 A CN201410422183 A CN 201410422183A CN 104147229 B CN104147229 B CN 104147229B
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Abstract
The present invention relates to a kind of Chinese medicine composition and compound preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type.It is by Herba Epimedii, Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, each 333g of Radix Angelicae Sinensis, each 166.5g composition of FLOS MUME, Sword Jackbean Seed, Flos Albiziae, Herba Leonuri and Fructus Schisandrae Chinensis; Method for making: get Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis add 70% ethanol 6 times amount, reflux, extract, 2 times, each 1.5 hours, merging filtrate, obtained alcohol extract; Medicinal residues and all the other 5 taste medicines decoct with water twice, each 2 hours, merging filtrate, when being concentrated into 60 DEG C, relative density is the clear paste of 1.15, adds ethanol and makes alcohol content reach 60%, staticly settle, get supernatant and above-mentioned alcohol extract merges, when being evaporated to 60 DEG C, relative density is the thick paste of 1.30, drying under reduced pressure, pulverize, add adjuvant, mixing, granulate, incapsulate, to obtain final product.This product has nourishing YIN and invigorating YANG, effect of Chong and Ren Meridians regulating.
Description
Technical field
The present invention relates to a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type, see for female climacteric syndrome kidney yin and yang deficiency type disease: dizziness and tinnitus, forgetful, how cold how hot, face is warmed, perspiration and aversion to wind, soreness of the waist and knees, red tongue with thin fur, arteries and veins cone number.
Background technology
Climacteric syndrome is also known as " perimenopausal syndrome ", it is hypo-ovaria before and after postmenopausal women, sexual hormone disturbance caused by neuroendocrine disorders or decline, thus there is reproductive system change and a series of syndrome group based on autonomic nervous dysfunction, belong to traditional Chinese medical science menopausal syndrome, also known as " before and after cracked ends all cards ".How because of madam seventy-seven year, kidney qi degradation, conception vessel declines void, taichong channel declines few, menses will exhaust, asthenia of essence and blood, imbalance of YIN and YANG and the function caused is not normal, usually can show as and warm that sweating, flushing hectic fever, irritable, feelings will are indefinite, palpitation and insomnia, dizziness and tinnitus, puffiness of the face and limbs, back are miserable etc.According to statistics, climacteric women number about 1.3 hundred million residing for China now, and there is related symptoms at climacteric in the women reaching 100,000,000 more than, 85% wherein suffering from climacteric syndrome, part even has influence on its quality of life.We take from Wuxue City clinical practice Empirical formula for many years, take Herba Epimedii as monarch drug, adopt multi-medicament composition of prescription, and through Yaogu Sci-Tech Development Co., Ltd., Wuhan by existing new drug requirements of customs declaration, preferred formulation moulding process, develop Chinese medicine, natural drug new drug six class Herba Leonuri climacteric recovering capsule, Fang Zhongshi simply medical material has been imperial medical material, not containing drug toxicity and eighteen incompatible medicaments, the medicine of the incompatibilitys such as nineteen medicaments of mutual restraint, its reasonable recipe, there is treating both the principal and secondary aspects of a disease, easy to use, quality controllable, drug effect is definite, safe and reliable advantage, the demand of extensive patients can be met.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type, and this medicine has nourishing YIN and invigorating YANG, Chong and Ren Meridians regulating.Before and after menopause, dizziness and tinnitus, forgetful, how cold how hot, face is warmed, perspiration and aversion to wind, soreness of the waist and knees, red tongue with thin fur, arteries and veins cone number.
Medicine of the present invention is made up of the raw material of Chinese medicine of following weight proportioning:
Herba Epimedii 166.5 ~ 499.5g FLOS MUME 55.5 ~ 277.5g Radix Rehmanniae Preparata 166.5 ~ 499.5g
Fructus Schisandrae Chinensis 55.5 ~ 277.5g Radix Polygoni Multiflori Preparata 166.5 ~ 499.5g Sword Jackbean Seed 55.5 ~ 277.5g
Radix Angelicae Sinensis 166.5 ~ 499.5g Flos Albiziae 55.5 ~ 277.5g Herba Leonuri 55.5 ~ 277.5g
The preferred weight proportioning of each raw material of the present invention is:
Herba Epimedii 277.5 ~ 388.5g FLOS MUME 111 ~ 222g Radix Rehmanniae Preparata 277.5 ~ 388.5g
Fructus Schisandrae Chinensis 111 ~ 222g Radix Polygoni Multiflori Preparata 277.5 ~ 388.5g Sword Jackbean Seed 111 ~ 222g
Radix Angelicae Sinensis 277.5 ~ 388.5g Flos Albiziae 111 ~ 222g Herba Leonuri 111 ~ 222g
The optimum weight proportioning of each raw material of the present invention is:
Herba Epimedii 333g FLOS MUME 166.5g Radix Rehmanniae Preparata 333g
Fructus Schisandrae Chinensis 166.5g Radix Polygoni Multiflori Preparata 333g Sword Jackbean Seed 166.5g
Radix Angelicae Sinensis 333g Flos Albiziae 166.5g Herba Leonuri 166.5g
Preparation method of the present invention is: above ten simply, gets Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, adds 70% ethanol 6 times amount, reflux, extract, 2 times, each 1.5 hours, merging filtrate, filters, obtains alcohol extract; Medicinal residues and all the other 5 taste medicines decoct with water twice, each 2 hours, and decocting liquid filters, merging filtrate, when being concentrated into 60 DEG C, relative density is the clear paste of 1.15, adds ethanol and makes alcohol content reach 60%, leave standstill and make precipitation, get supernatant and above-mentioned alcohol extract merges, recovery ethanol and when being evaporated to 60 DEG C relative density be the thick paste of 1.30,80 DEG C of drying under reduced pressure, pulverize, add appropriate amount of auxiliary materials, mixing, granulate, incapsulate, to obtain final product.
Medicine of the present invention can add one or more pharmaceutic adjuvants as required, pharmaceutic adjuvant can be diluent, binding agent, correctives, excipient, as sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin, magnesium stearate, micropowder silica gel.
The present invention can make any one according to existing process of Chinese medicine preparation and be applicable to clinical pharmaceutical preparation, comprises solid preparation (hard capsule, granule, tablet, dispersible tablet, soft capsule, drop pill, pill), liquid preparation (syrup, soft extract, oral liquid, mixture) etc.The preferred dosage form of the present invention is capsule, tablet.
The present invention is formed by ten a herb prescriptions, Herba Epimedii acrid, sweet, warm in side, and returning liver, kidney channel, have kidney-replenishing effect, is be monarch drug; Radix Rehmanniae Preparata is sweet, tepor, returns liver, kidney channel, has enrich blood YIN nourishing and Herba Epimedii and is all monarch drug, together play effect of nourishing YIN and invigorating YANG; Radix Polygoni Multiflori Preparata is bitter, sweet, puckery, tepor, returns liver, the heart, kidney channel, and what have nourishing the liver and kidney act as ministerial drug, the nourishing the liver of principal drug assistance kidney tonifying; Sword Jackbean Seed is sweet, and temperature, returns stomach, kidney channel, effect of tool kidney tonifying complement; Schizandronic acid, sweet, temperature, returns lung, the heart, kidney channel, effect of tool kidney calming; Flos Albiziae is sweet, flat, GUIXIN, Liver Channel, and energy nourishing kidney-yin, is all adjuvant drug with Sword Jackbean Seed, Radix Schisandrae Bicoloris, and principal drug assistance plays the merit of the kidney invigorating altogether; Radix Angelicae Sinensis sweet, acrid, warm, returns liver, the heart, spleen channel, has the effectiveness of menstruction regulating and pain relieving, except helping the monarch and his subjects will play except the effect of the liver benefiting, also reaches the object of YIN nourishing by nourishing " the foundation of acquired constitution "; FLOS MUME is sour, puckery, flat, returns liver, spleen, lung, large intestine channel, energy dispersing the stagnated live-QI to relieve the stagnation of QI; Radix Angelicae Sinensis and FLOS MUME are all adjuvant drug, together reach that tonifying liver is soothing the liver, effect of kidney tonifying YIN nourishing in side; Herba Leonuri is bitter, pungent, and be slightly cold, return liver, pericardium, urinary bladder channel, have promoting blood flow to regulate menstruation effect, its property is cold, can in anti-side other property of medicine excessively dry, make medicine in itself and the Radix Cynanchi Atrati side of being all.Full side plays nourishing YIN and invigorating YANG altogether, the merit of Chong and Ren Meridians regulating.Before and after menopause, dizziness and tinnitus, forgetful, how cold how hot, face is warmed, perspiration and aversion to wind, soreness of the waist and knees, red tongue with thin fur, arteries and veins cone number.
The climacteric syndrome model that pharmacodynamic experiment is set up by extracing rat both sides ovary, with diethylstilbestrol tablet, GENGNIANAN PIAN for contrast, gavage is after 30 days, and result display Herba Leonuri climacteric recovering capsule can increase rat uterus weight, improve estrogen (SE
2) level, reducing luteotropic hormone (LH) level, prompting Herba Leonuri climacteric recovering capsule can improve climacteric syndrome symptom.And by hospital application is faced to the routine patient of kidney yin and yang deficiency type climacteric syndrome 158, find serum SE after patient medication
2level significantly improves, and FSH level obviously declines (P<0.5), has statistical significance; And the total effective rate improved symptoms such as patient's soreness of the waist and knees, dry mouth and throat, headache and dizziness, Hiccough and deafs is 87.6%, illustrates that this capsule clinical effectiveness is satisfactory.
An important feature of the present invention is pure Chinese medicinal preparation, and determined curative effect, toxic and side effects are little, forms by motherland's traditional medicine prescription, the place of the through disease of drug effect.Meanwhile, after preparations shaping, facilitate carrying and taking of patient, and quality controllable, safety good.
Detailed description of the invention
Realize illustrating further of the present invention by following detailed description of the invention, but should not be understood to any limitation of the invention.
Press column weight amount and take raw material:
Herba Epimedii 333g FLOS MUME 166.5g Radix Rehmanniae Preparata 333g
Fructus Schisandrae Chinensis 166.5g Radix Polygoni Multiflori Preparata 333g Sword Jackbean Seed 166.5g
Radix Angelicae Sinensis 333g Flos Albiziae 166.5g Herba Leonuri 166.5g
Preparation method: above ten simply, gets Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, adds 70% ethanol 6 times amount, reflux, extract, 2 times, each 1.5 hours, and filter, merging filtrate, obtains alcohol extract; Medicinal residues and all the other 5 taste medicines decoct with water twice, each 2 hours, and decocting liquid filters, merging filtrate, when being concentrated into 60 DEG C, relative density is the clear paste of 1.15, adds ethanol and makes alcohol content reach 60%, leave standstill and make precipitation, get supernatant and above-mentioned alcohol extract merges, recovery ethanol and when being evaporated to 60 DEG C relative density be the thick paste of 1.30,80 DEG C of drying under reduced pressure, pulverize, add appropriate amount of auxiliary materials, mixing, granulate, incapsulate, to obtain final product.
Claims (3)
1. treat a Chinese medicine for female climacteric syndrome kidney yin and yang deficiency type, it is characterized in that it is made up of the raw material of Chinese medicine of following weight proportion:
Herba Epimedii 333g FLOS MUME 166.5g Radix Rehmanniae Preparata 333g
Fructus Schisandrae Chinensis 166.5g Radix Polygoni Multiflori Preparata 333g Sword Jackbean Seed 166.5g
Radix Angelicae Sinensis 333g Flos Albiziae 166.5g Herba Leonuri 166.5g.
2. the preparation method of the Chinese medicine for the treatment of female climacteric syndrome kidney yin and yang deficiency type according to claim 1, is characterized in that: get Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, adds 70% ethanol 6 times amount, reflux, extract, 2 times, each 1.5 hours, merging filtrate, filter, obtain alcohol extract; Medicinal residues and FLOS MUME, Radix Rehmanniae Preparata, Sword Jackbean Seed, Flos Albiziae, Herba Leonuri decoct with water twice, each 2 hours, and decocting liquid filters, merging filtrate, when being concentrated into 60 DEG C, relative density is the clear paste of 1.15, adds ethanol and makes alcohol content reach 60%, leave standstill and make precipitation, get supernatant and above-mentioned alcohol extract merges, recovery ethanol and when being evaporated to 60 DEG C relative density be the thick paste of 1.30,80 DEG C of drying under reduced pressure, pulverize, add adjuvant, mixing, granulate, incapsulate, to obtain final product.
3. preparation method according to claim 2, is characterized in that: described adjuvant is one or more in sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, microcrystalline Cellulose, aspartame, steviosin, magnesium stearate, micropowder silica gel.
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| CN105477264A (en) * | 2015-12-16 | 2016-04-13 | 青岛麦瑞特医药技术有限公司 | Medicinal preparation for treating urethral syndrome |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908539A (en) * | 2011-08-04 | 2013-02-06 | 苏吉永 | Traditional Chinese medicine for treating menopausal night sweats and preparation method of same |
| CN103169881A (en) * | 2012-12-28 | 2013-06-26 | 青岛华仁信息技术开发有限公司 | Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908539A (en) * | 2011-08-04 | 2013-02-06 | 苏吉永 | Traditional Chinese medicine for treating menopausal night sweats and preparation method of same |
| CN103169881A (en) * | 2012-12-28 | 2013-06-26 | 青岛华仁信息技术开发有限公司 | Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王治强治疗更年期综合征经验;王昃睿等;《中医杂志》;20071231;第48卷(第04期);310-311 * |
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