CN1633243A - 用于皮肤光保护作用的宠物食物组合物 - Google Patents
用于皮肤光保护作用的宠物食物组合物 Download PDFInfo
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- CN1633243A CN1633243A CNA038040832A CN03804083A CN1633243A CN 1633243 A CN1633243 A CN 1633243A CN A038040832 A CNA038040832 A CN A038040832A CN 03804083 A CN03804083 A CN 03804083A CN 1633243 A CN1633243 A CN 1633243A
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Abstract
用于宠物皮肤光保护作用的可摄入组合物,该组合物包含光保护有效量的、包含于可摄入载体中的i)至少一种益生乳酸细菌或其培养上清液,和ii)至少一种酵母和/或类胡萝卜素或其衍生物。
Description
发明领域
本发明涉及宠物食物组合物,用作皮肤的光保护作用,不论在皮肤暴露于紫外线辐射之前、之中和/或之后,本发明还涉及该组合物用作预防和/或削弱由这样的紫外线辐射引起的损伤的用途。它也涉及增强皮肤的光保护作用的方法。
发明背景
大气臭氧层的持续减少同时伴随着到达地球表面的紫外线辐射增加,这对人体健康的潜在影响已经引起了很大的兴趣。
确实,已知波长在320纳米至400纳米(UV-A)的光辐射促使人的表皮晒黑;然而这样的辐射可能对皮肤产生损伤,尤其是对于敏感的皮肤或连续暴露于太阳光辐射的皮肤。特别地,紫外线A导致皮肤弹性的损失和皱纹的出现,因此促使皮肤的过早老化。本领域已知波长在280至320纳米(UV-B)的光线引起红斑和皮肤灼伤,其能损害皮肤晒黑的自然进程。
虽然有必要暴露于紫外线辐射以产生维生素D,但是不断增加的证据提示广泛暴露于太阳光,特别是暴露于紫外线辐射,引起多种皮肤问题,包括诱发某些皮肤癌和诱使皮肤加速老化。
除了这些已确定的健康问题,研究也已经提供了证据提示暴露于紫外线辐射可能对生物体局部和全身的多种免疫应答有负面影响,其中所述局部为在紫外线照射的皮肤中,所述全身即在远离紫外线照射皮肤的部位。
因此,为了在暴露于紫外线辐射后维持适当的皮肤质量,有必要在暴露前做准备或处理皮肤,以在暴露期间保护它甚至减轻紫外线辐射对皮肤的有害作用,预防形成皮肤红斑、水肿和/或皮肤产生磷屑(角化过度症)。
因此,在本领域内需要能改进和/或加强宠物皮肤的光保护功能的口服组合物。
发明概述
因此,在第一个方面本发明旨在提供一种对皮肤起到光保护作用的可摄入的组合物,该组合物包含光保护有效量的包括在可口服载体中的i)至少一种益生乳酸细菌或它的培养上清液,和ii)至少一种酵母,和/或包含包括在可摄入载体中的一种类胡萝卜素或其衍生物。
本发明还涉及光保护有效量的i)至少一种益生乳酸细菌或它的培养上清液,和ii)至少一种酵母和/或一种类胡萝卜素或其衍生物的用途,用于制备可摄入的载体以保护宠物的皮肤免受诸如紫外线的辐射和所有相关的皮肤病,例如红斑、炎症、晒伤、功能障碍、光老化、免疫***的改变。
最后一个方面,本发明涉及用于改进宠物皮肤光保护功能的方法,它包括将组合物经口施与宠物的步骤,该组合物包含在可摄入载体中的的光保护有效量的i)至少一种益生乳酸细菌或它的培养上清液,和ii)至少一种酵母。
本发明也提供在宠物中减轻老化作用的方法,该方法包括给宠物喂饲如上描述的宠物食物组合物的步骤。
本发明的组合物对皮肤保护和皮肤着色有特别有益的效果,其有助于减小与紫外线相关的刺激对皮肤的影响。
发明详述
在以下叙述中,“NCC”指Nestlé Culture Col lection(Nestlé研究中心,Vers-chez-les-Blanc,洛桑,瑞士)。术语“光保护作用”用来描述阻滞或减少太阳辐射暴露对皮肤不利的临床的、组织学的和免疫学的影响。
根据本发明,目标组合物包含至少一种益生乳酸细菌或双歧杆菌或它们的培养上清液,和至少一种酵母和/或一种类胡萝卜素的组合混合物用作活性剂。
确实,现在已令人惊讶和出乎意料地证明这些非常特别的组分的混合物诱发对皮肤的光保护作用的增强效果或应答。
益生菌是非病原的和不产生毒素的有机体,其通过胃和小肠段后仍存活。通过寄主的持续摄入,它们最终可能在肠中定居成相当大的量从而与潜在的其它病原细菌争夺养分和/或在胃肠壁上的附着位点并减少这些病原菌数和减少或预防感染。到目前为止已经发现许多不同的益生微生物,据报道它们都通过产生毒素、新陈代谢的副产物、短链脂肪酸等对肠道产生作用。
现已显示益生菌在远离它们定居区的位置对个体的身体也确实施加影响。且特别地,已令人惊讶地发现对皮肤具有协同的光保护功效的组合物可通过将益生微生物和酵母组合入可摄入的载体而获得。
在一个优选实施方案中,包含于载体中的益生菌选自于乳酸细菌,特别是乳杆菌属(Lactobacilli)、双歧杆菌属(Bifidobacteria)或肠球菌属(Enterococci);更优选约氏乳杆菌(Lactobacillus johnsonii)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillus rhamnosus)、副干酪乳杆菌(Lactobacillus paracasei)、干酪乳杆菌(Lactobacillus casei)或两歧双歧杆菌(Bifidobacterium bifidum)、短双歧杆菌(Bifidobacteriumbreve)、长双歧杆菌(Bifidobacterium longum)、动物双歧杆菌(Bifidobacterium animalis)、乳双歧杆菌(Bifidobacterium lactis)、婴儿双歧杆菌(Bifidobacterium infantis)、青春双歧杆菌(Bifzdobacteriumadolescentis)、假小链双歧杆菌(Bifidobacterium pseudocatenulatum)、粪肠球菌(Enterococcus faecium)、某种肠球菌(Enterococcus sp.)或它们的混合物。
根据一个最优选的实施方案,菌株约氏乳杆菌NCC 533、副干酪乳杆菌NCC 2461、青春双歧杆菌NCC 251和长双歧杆菌NCC 490作为例子被保藏在布达佩斯条约的巴斯德研究所(28 rue du Docteur Roux,F-75024Paris cedex 15)分别于1992年6月30日,1999年1月12日,1999年4月15日和1999年3月15日保藏且保藏号分别为CNCM I-1225、CNCMI-2116、CNCM I-2168和CNCM I-2170。
由Hansen(Chr.Hansen A/S,10-12 Boege Alle,P.O.Box 407,DK-2970 Hoersholm,Danemark)提供的乳双歧杆菌菌株(ATCC27536)也可使用。
根据本发明的益生微生物可以活的、半活的或去活的形式,如作为一种冷冻干燥的粉末被包含。且微生物的培养上清液可任选地以浓缩的形式被包括在产品中。它也可以包封的形式包括。当使用益生菌培养上清液时,上清液在被包括入产品之前可原样使用或经过一步或多步提纯步骤,以浓缩或分离活性成分/代谢物。用于提纯化合物和检测得到的级分中的化合物活性的方法和技术为本领域技术人员所熟知。
益生乳酸细菌存在于载体中的量可以至少是105菌落形成单位/克可摄入载体,优选从约105-1015菌落形成单位/克可摄入载体,且更优选从107-1012菌落形成单位/克可摄入载体。
它可单独的或者在混合物中以分散的形式被并入合适的载体如水、有机溶剂和包括油的脂肪物质。
根据本发明的组合物也包含酵母。在一个优选实施方案中,酵母是选自于子囊菌亚门(Ascomycotina)或半知菌亚门(Deuteromycotina)的任何食用级酵母。在一个优选实施方案中,酵母可选自德巴利酵母属(Debaryomyces)、克鲁维酵母属(Kluyveromyces)、酵母属(Saccharomyces)、Yarrowia、接合酵母属(Zygosaccharomyces)、假丝酵母属(Candida)和红酵母属(Rhodotorula),更优选酿酒酵母(Saccharomyces caerevisae)(面包酵母)。
这样的酵母可以干燥的或冷冻干燥的提取物的形式被使用。它存在于载体中的量可以至少是105菌落形成单位/克可摄入载体,优选从约105至1015菌落形成单位/克可摄入载体,和更优选从107至1012菌落形成单位/克可摄入载体,所述的量取决于特定酵母的性质和活性。
类胡萝卜素可以是具有或没有前维生素A活性的类胡萝卜素。它可以是β-胡萝卜素、γ-胡萝卜素、α-胡萝卜素、番茄红素、玉米黄素和叶黄素,或它们的混合物。类胡萝卜素可以是人工合成或天然来源或包含在天然提取物中。如果类胡萝卜素是天然来源,则优选获于植物材料,其中植物生长于自然条件下或在玻天然环境。提取类胡萝卜素的方法是本领域内熟知的。类胡萝卜素存在于载体中的量可以从10-12%至20%重量和优选从0.00001毫克至50毫克/天和更优选从0.001毫克-30毫克/天。
众多乳酸细菌、酵母和/或类胡萝卜素的混合物也可使用。
载体可以是任一种宠物食物或药用产品,或者营养增补剂或点心(treat),其中益生微生物即酵母和/或类胡萝卜素可以被包括在内。制备载体的方法是常识。
所述组合物可以作为正常饮食的增补剂或作为营养完全的宠物食物的组分施与宠物。它也可以是一种药用组合物。
根据本发明的营养完全的宠物食物组合物可以是粉末状的、干燥形式的点心或者是湿的、冷藏的或货架稳定的宠物食物产品。这些宠物食物可以通过本领域内已知的方法生产。除了植物和植物提取物,这些宠物食物可以包括淀粉源、蛋白源或脂质源中的任何一种或多种。
合适的淀粉源是,例如,谷类和荚果类诸如玉米、稻谷、小麦、大麦、燕麦、大豆,和这些物质的混合物。合适的蛋白源可以选自于任一种合适的动物或植物蛋白源;例如肉粉、禽肉粉、鱼粉、大豆蛋白浓缩物、乳蛋白、谷蛋白等。对于较老的动物,蛋白源优选包含高质量蛋白。合适的脂质源包括肉、动物脂肪和植物脂肪。
淀粉、蛋白和脂质源的选择很大程度上取决于动物的营养需要,适口性考虑,和所应用的产品类型。对于较老的宠物,宠物食物优选包含比年幼宠物食物较少比例的脂肪量。另外,淀粉源可以包括稻谷、大麦、小麦和玉米中的一种或多种。
宠物食物任选地也可以包含益生素或另一种活性剂,例如长链脂肪酸。益生素在宠物食物中的量优选低于10%重量。例如,益生素可以占宠物食物重量的约0.1%至约5%。对于用菊苣作为益生素源的宠物食物,被包括的菊苣的重量可以占饲料混合物的约0.5%至约10%;更优选约1%至约5%重量。
合适的长链脂肪酸包括亚油酸、α-亚油酸、γ-亚油酸、二十碳五烯酸和二十二碳六烯酸。鱼油是二十碳五烯酸和二十二碳六烯酸的合适来源。琉璃苣油、黑醋栗籽油和月见草油是γ-亚油酸的合适来源。红花油、向日葵油、玉米油和大豆油是亚油酸的合适来源。
如果需要,宠物食物可补充有矿物质和维生素使得它们营养完全。另外,多种其它成分,如糖、盐、香料、调料、调味剂等也可以如所需要的那样掺入宠物食物。
对于干燥的宠物食物,合适的处理是挤压蒸煮,尽管烘焙和其它合适的处理可被使用。如果挤压蒸煮,干燥的宠物食物通常以粗粉的形式被供给。如果使用益生素,在处理前,益生素可以和干燥的宠物食物的其它成分混合。一种合适的处理过程在欧洲专利申请号0850569中描述。如果使用益生微生物,生物体优选被涂在或填充进干燥的宠物食物。一种合适的处理过程在欧洲专利申请号0862863中描述。
对于湿的食物,在美国专利4,781,939和5,132,137中描述的处理方法可用于生产模拟的肉产品。生产块状产品的其它方法也可使用;例如在蒸汽炉上蒸煮。备选地,块产品可通过乳化合适的肉料成肉糜,加入合适的胶凝剂,并在装入罐或其它容器之前加热肉糜来生产。
在另一方面,本发明涉及改进宠物皮肤的光保护功能的方法,该方法包括将组合物经口施与宠物的步骤,该组合物包含在可摄入载体中的光保护有效量的i)至少一种益生乳酸细菌或者它的培养上清液,和ii)至少一种酵母和/或类胡萝卜素或它的衍生物。
被个体消耗的组合物的量取决于所欲达到的功效。但是,每日提供约105至1012个活的或死的生物体和0.00001毫克至50毫克类胡萝卜素的组合物的量通常是足够的。
组合物在个体暴露于紫外线辐射尤其是暴露于太阳光之前或其间被施与个体。如果暴露期间是可预知的,最好从10至20天前开始施用所述组合物,且在暴露期间继续施用时间。
为了进一步阐述本发明和它的优点,下面给出具体的例子,需要理解的是这些例子仅以阐述本发明为目的而决不限制本发明。在下面的例子中,同上面的描述一样,如果没有另外指明,所有份数和百分比指重量比。
实施例
实施例1:干燥的狗食
饲料混合物由约58%重量的玉米,约5.5%重量的玉米谷蛋白,约22%重量的鸡粉,2.5%的干菊苣,剩下的组分是盐、维生素和矿物质。
将饲料混合物装进预调节器并被湿润。然后湿润的食物被放入一个挤压机-蒸煮器并制成胶状。离开挤压机的胶状基质被强迫通过一个模具并被挤压。压出物被切成适于狗食用的碎块,在约110℃干燥约20分钟,并冷却形成小球。这时,菌株CNCM I-1225、CNCM I-2116、CNCM I-2168、CNCM I-2170或ATCC 27536之一的冷冻干燥粉和酿酒酵母的冷冻干燥粉(每种冷冻干燥粉相应的量大约是1.0E+05-1.0E+12菌落形成单位/天)可被加入并与产品混合。另外,小球于50-60℃干燥数分钟后,将等量的细菌喷到冷却的小球上面。
此干燥狗食有助于保护宠物皮肤的抵抗太阳有害紫外线的天然防御能力。
实施例2:罐装宠物食物和增补剂。
由73%家畜肉、猪肺和牛肝(磨细)、16%的小麦面粉、2%的染料、维生素和无机盐制备混合物。该混合物在12℃被乳化并以布丁的形式被挤压然后在90℃蒸煮。冷却至30℃并被切成块状。45%的这些块状物与用98%的水、1%的染料和1%的瓜尔豆胶制成的55%的调味料混合。充填锡罐并在125℃灭菌40分钟。在作为一份食物提供前,欲与宠物食物混合的益生增补剂额外包装(如小袋),其中具有菌株CNCM I-1225、CNCM I-2116、CNCM I-2168、CNCM I-2170或ATCC 27536之一和β-胡萝卜素和冷冻干燥的酿酒酵母。喂宠物的相应的量大约是105-1012菌落形成单位/天的微生物和0.1至50毫克的类胡萝卜素,可作为锡罐的附加物被供给(如在锡罐上层)。
Claims (18)
1.用于皮肤光保护作用的可摄入组合物,其包含光保护有效量的、包含于可摄入载体中的i)至少一种益生乳酸细菌或其培养上清液,和ii)至少一种酵母和/或类胡萝卜素或其衍生物。
2.根据权利要求1的组合物,其中乳酸细菌选自乳酸菌,优选乳杆菌属(Lactobacilli)、双歧杆菌属(Bifidobacteria)或肠球菌属(Enterococci)。
3.根据权利要求1或2的组合物,其中乳酸细菌是约氏乳杆菌(Lactobacillus johnsonii)、罗伊氏乳杆菌(Lactobacillus reuteri)、鼠李糖乳杆菌(Lactobacillus rhamnosus)、副干酪乳杆菌(Lactobacillusparacasei)、干酪乳杆菌(Lactobacillus casei)或两歧双歧杆菌(Bifidobacterium bifidum)、短双歧杆菌(Bifidobacterium breve)、长双歧杆菌(Bifidobacterium longum)、动物双歧杆菌(Bifidobacteriumanimalis)、乳双歧杆菌(Bifidobacterium lactis)、婴儿双歧杆菌(Bifidobacterium infantis)、青春双歧杆菌(Bifzdobacteriumadolescentis)、假小链双歧杆菌(Bifidobacterium pseudocatenulatum)、粪肠球菌(Enterococcus faecium)、某种肠球菌(Enterococcus sp.)或它们的混合物。
4.根据权利要求1至3中任意一项所述的组合物,其中乳酸细菌是CNCM I-1225、CNCM I-2116、CNCM I-2168或CNCM I-2170。
5.根据权利要求1至4中任意一项所述的组合物,其中益生乳酸细菌以活的、半活的或者以去活形式包含于载体中,优选以冷冻干燥粉形式包含于载体中。
6.根据权利要求1至5中任意一项所述的组合物,其中类胡萝卜素是具有或没有前维生素A活性的类胡萝卜素,如β-胡萝卜素、γ-胡萝卜素、α-胡萝卜素、番茄红素、玉米黄素和叶黄素,或为它们的混合物。
7.根据权利要求1至6中任意一项所述的组合物,其中酵母选自德巴利酵母属(Debaryomyces)、克鲁维酵母属(Kluyveromyces)、酵母属(Saccharomyces)、Yarrowia、接合酵母属(Zygosaccharomyces)、假丝酵母属(Candida)和红酵母属(Rhodotorula),或它们的一种混合物。
8.根据权利要求7的组合物,其中酵母是酿酒酵母(S.cerevissae)。
9.根据权利要求1至8中任意一项所述的组合物,其为i)粉状、干燥的或湿的、冷藏的或货架稳定形式的营养完全的宠物食物形式或ii)饮食添加剂或增补剂或点心的形式。
10.光保护有剂量的至少一种益生乳酸细菌或其培养上清液和至少一种酵母和或类胡萝卜素的用途,用于制备可摄入的载体,以保护皮肤免受太阳辐射并减轻或预防所有相关的皮肤病。
11.根据权利要求10的用途,其中乳酸细菌是约氏乳杆菌、罗伊氏乳杆菌、鼠李糖乳杆菌、副干酪乳杆菌、干酪乳杆菌或两歧双歧杆菌、短双歧杆菌、长双歧杆菌、动物双歧杆菌、乳双歧杆菌、婴儿双歧杆菌、青春双歧杆菌、假小链双歧杆菌、粪肠球菌、某种肠球菌或它们的混合物。
12.根据权利要求10或11的用途,其中乳酸细菌是CNCM I-1225、CNCM I-2116、CNCM I-2168、CNCM I-2170或ATCC 27536。
13.根据权利要求10至12中任意一项所述的用途,其中酵母选自德巴利酵母属、克鲁维酵母属、酵母属、Yarrowia、接合酵母属、假丝酵母属和红酵母属,或为它们的混合物。
14.根据权利要求10至13中任意一项所述的用途,其中益生乳酸细菌存在于载体中的量为约105至1012个菌落形成单位/克载体,酵母为约105至1015个菌落形成单位/克载体。
15.根据权利要求10至13中任意一项所述的用途,其中类胡萝卜素存在于载体中的量为10-12%至20%重量。
16.根据权利要求10至15中任意一项所述的用途,用于制备轻减宠物光致老化作用的组合物。
17.用于改进宠物皮肤光保护功能的方法,该方法包括将组合物经口施与宠物的步骤,该组合物包含在可摄入载体中的i)至少一种益生乳酸细菌或其培养上清液,和ii)至少一种酵母和/或类胡萝卜素或其衍生物。
18.根据权利要求17的方法,其中组合物为根据权利要求1至9中任意一项的组合物。
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CN109475583B (zh) * | 2016-03-24 | 2022-07-29 | 株式会社明治 | 用于抑制红斑产生的组合物及其使用方法和制造方法、抑制红斑产生的方法、乳酸菌产物 |
CN111909882A (zh) * | 2020-09-10 | 2020-11-10 | 青岛普罗百世生物科技有限公司 | 一种副干酪乳杆菌及其在宠物犬犬粮中的应用 |
CN111909882B (zh) * | 2020-09-10 | 2022-05-13 | 青岛普罗百世生物科技有限公司 | 一种副干酪乳杆菌及其在宠物犬犬粮中的应用 |
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AU2003210311A1 (en) | 2003-09-09 |
EP1478242B1 (en) | 2014-04-30 |
BR0307840A (pt) | 2004-12-07 |
EP1478242A1 (en) | 2004-11-24 |
ES2462535T3 (es) | 2014-05-23 |
MXPA04008187A (es) | 2004-11-26 |
ZA200407552B (en) | 2005-12-28 |
JP2010263910A (ja) | 2010-11-25 |
CN100592905C (zh) | 2010-03-03 |
RU2334404C2 (ru) | 2008-09-27 |
US20050158291A1 (en) | 2005-07-21 |
JP2005517419A (ja) | 2005-06-16 |
AU2003210311B2 (en) | 2008-02-14 |
AU2003210311C1 (en) | 2009-04-02 |
WO2003070019A1 (en) | 2003-08-28 |
TW200303724A (en) | 2003-09-16 |
CA2476619A1 (en) | 2003-08-28 |
RU2004127988A (ru) | 2005-05-10 |
AR038593A1 (es) | 2005-01-19 |
CA2476619C (en) | 2011-09-20 |
US20090104169A1 (en) | 2009-04-23 |
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