CN1628754A - Local externally applied itch stopping garlic paint - Google Patents

Local externally applied itch stopping garlic paint Download PDF

Info

Publication number
CN1628754A
CN1628754A CN 200410020382 CN200410020382A CN1628754A CN 1628754 A CN1628754 A CN 1628754A CN 200410020382 CN200410020382 CN 200410020382 CN 200410020382 A CN200410020382 A CN 200410020382A CN 1628754 A CN1628754 A CN 1628754A
Authority
CN
China
Prior art keywords
varnish
antipruritic
extract
bulbus allii
garlic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN 200410020382
Other languages
Chinese (zh)
Other versions
CN100488543C (en
Inventor
王传
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Qingsong Pharmaceutical Group Co ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CNB2004100203820A priority Critical patent/CN100488543C/en
Publication of CN1628754A publication Critical patent/CN1628754A/en
Application granted granted Critical
Publication of CN100488543C publication Critical patent/CN100488543C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Medicines Containing Plant Substances (AREA)

Abstract

The invention provides a partially externally used relieve itching epithem and its preparation process, wherein the epithem employs garlic as the principal active composition, the preparation comprises selecting fresh ripened garlic bulb or haulm or scape and disintegrating, charging different solvent, steeping or mixing, extracting 0.5-12 hours at 20-90 deg. C, stewing 10-20 hours at 4-25 deg. C, decompressing and concentrating, and mixing the extract and right amount of medicinal adjuvant.

Description

The antipruritic varnish of Bulbus Allii local topical
Technical field
The present invention relates to contain the external preparation of Chinese medicine ingredients, say so more specifically about being the antipruritic varnish of local topical of main active with Bulbus Allii or its extract.Be applied in application on human skin pruritus position and produce obviously and rapidly antipruritic effect.
Background technology
Skin pruritus is the skin pruritus that people often run in the daily life problem a variety of causes causes, as senile skin pruritus, and the atopic dermatitis disease of itching, foot's skin is itched due to the tinea pedis, allergy causes that skin is itched etc. is clinically extensively and the symptom of sending out repeatly.The due to mosquito bites red swelling of the skin was itched and was difficult to especially avoid summer.Skin pruritus, though be unlikely to life-threatening, the gargalesthesia of outbreak causes very big discomfort, has had a strong impact on people's work and sleep the people again and again.To the treatment of this disease, mainly be in the past,, took Claritin usually as the erythra pruritus that allergy is caused at the cause of disease.To pruritus due to the fungoid tinea, oral usually or smear antifungal agent outward.To due to mosquito bites itch and atopic dermatitis due to itch, usually smear adrenocortical hormones external agent, and to the geroderma pruritus, the external use anti pruritic agent that contains aromatic oil more commonly used.Though said medicine has certain curative effect, its application has limitation, and some oral drugs and external hormone medicine also have many side effect, the another one problem, the said medicine antipruritic effect is slow and antipruritic effect is not obvious, the cause of disease such as have only to disappear after, gargalesthesia just ends.
Japan Patent 08-165233A discloses one " bath shampoo that the antipruritic effect is arranged " except that containing general bath shampoo composition, the extract that moisture-keeping function is arranged that also contains Bulbus Allii extract and have the itching-relieving action plant extract in addition and extract from animal tissue.But this bath shampoo is to be applied in before shower on the skin, takes a shower then and washes out, rather than be applied on the skin as external used medicine, puts and stays the place of itching, and itching-relieving action is not obvious, uses also very inconvenience, only could use before shower.
At the problems referred to above, particularly consider due to mosquito bites red swelling of the skin pruritus in summer, foot pruritus due to the veteran form skin pruritus, tinea pedis, take place frequently every day, and troublesome can't bear to stand.Therefore, from natural plants research, attempt to develop rapid, the obvious and preparation and easy to use of a kind of antipruritic effect, cheap external use anti pruritic medicament just seems particularly important.
The inventor has compared the effect of the traditional Chinese medicine that has itching-relieving action of multiple China to the human body pruritus simultaneously through experimentation painstakingly repeatedly for many years, found that, Bulbus Allii and extract thereof have tangible antipruritic function rapidly to the disease of itching due to a variety of causes.
Bulbus Allii is the Liliaceae allium, and the Latin formal name used at school is Allium Sativam L, is distributed in other various places of the China and the world.Its underground bulb is mainly as flavoring agent.Its fresh and tender full stand and scape be the Chang Zuowei vegetable again.The Compendium of Materia Medica record, the hot temperature of this product abnormal smells from the patient is returned spleen, lung, kidney channel.Main cholera, uneasy in the abdomen, rapid digestion of food, reason stomach, warming middle-JIAO.Remove evil addiction poison.Modern medicine studies show that, Bulbus Allii or its extract have antibioticly, parasite killing, antitumor, separate liver poison, blood pressure lowering, blood fat reducing, anticoagulant, blood sugar lowering, antioxidation isoreactivity.Again to the report of hyperlipemia, atherosclerosis, influenza, cruchet's disease, pertussis, tubercle bacillus affection, bacillary and amebic dysentery, enteritis, dyspepsia, helminth, trichomonas vaginitis and cutaneous diseases, has good effect clinically.
Summary of the invention
The shortcoming that one object of the present invention is to overcome prior art is with not enough, and providing a kind of is the antipruritic varnish of local topical of main active with the Bulbus Allii extract.It has rapid-action, antipruritic effect is obvious, nontoxic, the characteristics that have no side effect.
Another object of the present invention is to provide a kind of is main active with the Bulbus Allii extract, also contains the antipruritic varnish that other antibiotic, itching relieving Chinese medicinal plant are made simultaneously.
A further object of the present invention is to provide the application of a kind of antipruritic varnish in preparation treatment tinea pedis medicine.
Of the present invention is the antipruritic varnish of local topical of main active with the Bulbus Allii extract, mainly comprises
(1). choose fresh ripe garlic bulb or new fresh and tender Bulbus Allii stem and leaf and scape, the preferred maturity garlic bulb is pulverized.
(2). doubly measure the adding different solvents by the heavy 0.5-5 of raw material and soak or stirring;
(3) .20-90 ℃ of extraction extracted 0.5-12 hour, removed by filter filtering residue, and extracting solution left standstill 10-20 hour in 4-25 ℃;
(4). get Bulbus Allii extract behind the extracting solution concentrating under reduced pressure;
(5). extract and proper quantity of medicinal auxiliary material are mixed and made into antipruritic varnish; Wherein by weight, contain garlic bulb 10-700g in every hectogram or per hundred milliliters of antipruritic varnishs.
Described Bulbus Allii extract comprises: 1, ripe garlic bulb or other parts after grinding, the juice that squeeze and filter goes out and the concentrate of juice (concentrate and extract drying solid thing).2, each medicinal part of Bulbus Allii (mainly being bulb) is after grinding, with the extract (comprise liquid extract, half consolidates shape concentrate or exsiccant solid extract) of different solvents extraction.
Described different solvents is a pure water, aquiferous ethanol and ethanol, aqueous propylene glycol and propylene glycol, aqueous acetone or acetone etc.Preferred pure water, aquiferous ethanol, ethanol.
Described extracting method specifically can prepare as follows: after the medicinal part of fresh garlic is ground, add its weight 0.5-5.0 extraction solvent doubly, preferred 2-5 doubly soaks and extracts or stir and extract, and temperature 20-90 ℃, preferred 25-70 ℃.Extraction time 0.5-12 hour, preferred extraction time 1-5 hour.After the extraction, remove by filter filtering residue.As use water extraction, and extracting solution is then placed more than 10 hours in 4 ℃ or room temperature, filters out deposit, and clear liquid can be directly used in preparation external use anti pruritic varnish.As with containing alcohol or ketone organic solvent extraction, then decompression removes organic solvent, and water liquid is also placed more than 10 hours in 4 ℃ or room temperature, filters out precipitate, and clear liquor can be directly used in preparation external use anti pruritic varnish.
By the present invention, Bulbus Allii external use anti pruritic varnish contains the amount of Bulbus Allii or its extract, calculates to contain fresh ripe garlic bulb in Unit Weight or the unit volume, and 100ml masking liquid or 100g are coated with and contain garlic bulb 10-700g in the cream, preferred 40-100g.
By the present invention, the independent application of Bulbus Allii extract just has strong antipruritic effect, but the present invention also can contain at least a other has anti-inflammation, the plant of itching-relieving action, comprise Flos Chrysanthemi Indici (chysanthenumindium L), Herba Menthae (Menta haplocylyx Briq, and other kinds) still can replace with the Mentholum or the menthol of appropriate amount.Herba Schizonepetae (Schizonepeta tendifolia Briq), Folium Perillae (Perilla frutescens L), Folium Artemisiae Argyi extracts such as (Artemisia argyi le VL et vant).Its extracting method can adopt and the identical prepared of above-mentioned Bulbus Allii extracting method.Or the water that adopts the Chinese medicine routine is carried, precipitate with ethanol, go up the method that macroporous resin separates eluting and make extracts such as Flos Chrysanthemi Indici, Herba Schizonepetae, Folium Perillae, Folium Artemisiae Argyi.
These plants can strengthen the itching-relieving action of Bulbus Allii, when suitably reducing Bulbus Allii or extract consumption, good antipruritic effect is also arranged, and can reduce the distinctive stink of Bulbus Allii.Bulbus Allii extract and other have the proportioning of the plant of itching-relieving action, press solid or concentrated extract and calculate, and other plant extract is minimum to be 0.1 times of Bulbus Allii extract, is preferably 0.5-5.0 times.
The antipruritic varnish of local topical of Bulbus Allii of the present invention (and containing other itching-relieving action plant extracts) comprises and can directly use Bulbus Allii to press juice, garlic extract (not containing or contain small amount of ethanol).The externally-used embrocation of preferred Bulbus Allii extract (and containing the plant extract that itching-relieving action is arranged in addition) preparation.Described external use anti pruritic liniment comprises liquid masking liquid (solution, suspension, emulsion) and ointment (comprising ointment, gel, cream) etc.
The antipruritic varnish of local topical of the present invention except that containing antipruritic active component, still can add pharmaceutic adjuvant commonly used such as excipient, spice, pigment, solubilizing agent, penetrating agent etc.
Varnish of the present invention can prepare by the conventional method of external medicine preparation:
1. liquid varnish: with the Bulbus Allii aqueous extract (as extracting with ethanol water, extracting solution then boils off ethanol, and aqueous extract) or Bulbus Allii extract condensed matter (or solids) and be dissolved in the pure water, add appropriate amount ethanol or propylene glycol, spice, pigment are formulated.
2. antipruritic ointment (comprising gel, cream): Bulbus Allii is extracted concentrate or solids joins in ointment or the gel substrate, add appropriate amount spice simultaneously, pigment grinds mixing and promptly gets the external paste.
Bulbus Allii and other have the varnish of the plant extract of itching-relieving action, also by preparing with quadrat method.
Pruritus of the present invention comprises: the mosquito bite red swelling of the skin is itched, senile skin pruritus, and tinea is itched (comprising foot Testudinis tinea) due to the fungus, and atopic dermatitis is itched, and allergic skin is itched etc.
The inventor's surprised discovery in experiment in addition, Bulbus Allii external use anti pruritic varnish has shown excellent curative in preparation treatment tinea pedis medicine.Suffer from tinea pedis experimenter for many years and using this varnish 10-15 days, behind the every day minimum secondary, tinea pedis is cured, and does not have recurrence.
Be the clinical effectiveness statistics antipruritic on probation of Bulbus Allii local topical varnish below:
Mosquito bite is itched:
5-65 year health volunteer 50 examples time, behind the mosquito bite, skin erythema occurs and itches, with cotton balls Bulbus Allii antipruritic liquid (or Itch Stopping Gel) is applied to the place of itching, the inferior antipruritic effect that produces immediately of 65% example, all the other example time gargalesthesias obviously alleviate, itched in several minutes and end, red and swollen place also dies down.
Senile skin pruritus:
Age 60-75 year health volunteer, 20 examples are suffered from skin pruritus for many years, show effect 2-3 time every day, mostly occur at skin of back, itch unbearably.Be coated with this antipruritic varnish during the pruritus outbreak, 65% patient only itches or gargalesthesia is arranged slightly, and 35% example is inferior obviously to be alleviated, and can fall asleep, but can not eradicate, and has only antipruritic effect.
Tinea pedis is itched:
Age 25-65 year health volunteer, 50 examples time (8 people) are suffered from tinea pedis for many years more, once used antifungal external agent such as daktarin, more back recurrence, the variable interval every day pruritus occurs unbearably, smear this product after, 80% example is inferior can gargalesthesia antipruritic at once or slightly, all the other people also obviously alleviate, and in addition, 6 people are arranged after repeatedly smearing this product (10-15 days, every day minimum secondary), tinea pedis is cured.
Of the present invention is the antipruritic varnish of local topical of main active with the Bulbus Allii extract, antipruritic demonstration on probation, and antipruritic effect is obviously rapid, and preparation and easy to use, cheap, tinea not only there is good antipruritic effect, the treatment of tinea (as tinea pedis) also there is good result.Varnish is applied in the place of itching to get final product.
The specific embodiment
The present invention will be further described below in conjunction with instantiation:
Example 1:
Garlic bulb is pressed the juice preparation: ripe garlic bulb 100g, grind pressure juice, and Bulbus Allii juice is placed more than 10 hours in 4 ℃ or room temperature, leach precipitate, must clarify Bulbus Allii juice 50ml, can directly or through suitable dilute with water can be used as the preparation externally-used embrocation.
Example 2:
Ripe garlic bulb 100g grinds adding pure water 200ml in 65 ± 5 ℃, stirs 2 hours, places room temperature and filters, and gets aqueous extract.4 ℃ of this extracting solution were placed 8 hours, or static 12 hours of room temperature, the centrifugal filtration disgorging, primary water extracting solution 180ml, can be directly used in the preparation varnish, or behind the concentrating under reduced pressure, refabrication externally-used embrocation behind preparation concentrated extract or the solid extract.
Example 3:
Ripe garlic bulb 100g, grind and add 70% ethanol water 500ml, stir extraction in 4 hours, placement room temperature in 75 ± 5 ℃, remove by filter the Bulbus Allii slag, extracting solution was placed 6 hours in 4 ℃, remove by filter precipitate, clear liquor pressure reducing and steaming ethanol, add pure water to 200ml, this water liquid was placed 10 hours in room temperature, the centrifugal filtration disgorging must extract water liquid, can directly prepare externally-used embrocation again as preparation external use anti pruritic varnish or after further concentrating under reduced pressure must extract concentrate (thickness semisolid or solid).
Example 4:
Flos Chrysanthemi Indici was gathered autumn, was collected in Greater, Baoding, Hebei province Flos Chrysanthemi Indici (through identifying) (yellow flower and pistil).Dry, get 50g and add water 120ml pure water, soaked 4 hours in 65 ℃, extracting solution is got in squeezing, and room temperature was placed 6 hours, removed by filter precipitate, get light yellowish brown fragrance clear liquor, this also can directly and behind Bulbus Allii extract merging preparation external use anti pruritic varnish or the concentrating under reduced pressure prepare varnish again.
According to said method can make the clear liquor of Herba Schizonepetae, Folium Perillae, Folium Artemisiae Argyi, behind concentrating under reduced pressure, make the extract of Herba Schizonepetae, Folium Perillae, Folium Artemisiae Argyi;
Example 5:
Press the garlic bulb extracting solution 200ml of embodiment 3 preparations, add the appropriate amount propylene glycol, make content reach 20%, the water extract concentrated solution 50ml (containing derived essential oil) that adds fresh Folium Artemisiae Argyi 50g preparation then, and the essence of appropriate amount, stirring and dissolving makes masking liquid behind the mix homogeneously.
Example 6
Press the garlic bulb extracting solution 150ml of embodiment 1 or 2 preparations, press the Flos Chrysanthemi Indici extracting solution 50ml that example 4 extracts, both merge mix homogeneously, add the appropriate amount propylene glycol, make to contain 20%, add Mentholum 1g then, add the appropriate amount pigment simultaneously and the spice mix homogeneously is made antipruritic masking liquid.
Example 7:
Get carbomer (Chinese Pharmacopoeia standard) 2.0g powder, under slowly stirring, be added in the 180ml pure water to dissolving, get gelling material, splash into saturated aqueous sodium carbonate then, regulate PH7.0-7.5, add 100g garlic bulb extract concentrated solution then, reach suitable spice, pigment, Mentholum, stir,, remove bubble and promptly get the antipruritic gel of smearing in 60-65 ℃ of decompression.
Example 8:
By the 200g garlic bulb water concentration of the embodiment 2 preparation extractum that contracts, it is joined among the oil-in-water ointment 100g, add the alcoholic solution of 0.75g Mentholum and the essence of appropriate amount simultaneously, mixed grinding is even, makes the antipruritic ointment agent.

Claims (6)

1, a kind of is that the antipruritic varnish of local topical of main active is characterized in that with the Bulbus Allii extract, this varnish is obtained by following method: choose fresh ripe garlic bulb or stem and leaf or scape and pulverize, doubly measuring the adding different solvents by the heavy 0.5-5 of raw material soaks or stirring, extracted 0.5-12 hour in 20-90 ℃, remove by filter filtering residue, extracting solution is in 4-25 ℃, left standstill 10-20 hour, get Bulbus Allii extract after getting the supernatant concentrating under reduced pressure, extract and proper quantity of medicinal auxiliary material are mixed and made into antipruritic varnish; Wherein by weight, contain garlic bulb 10-700g in every hectogram or per hundred milliliters of antipruritic varnishs.
2, antipruritic varnish as claimed in claim 1 is characterized in that also containing the extract of Herba Menthae, Flos Chrysanthemi Indici, Herba Schizonepetae, Folium Perillae, Folium Artemisiae Argyi; Wherein extract be by weight Bulbus Allii extract 0.1-5 doubly.
3, antipruritic varnish as claimed in claim 1 is characterized in that, described different solvents is pure water, ethanol, ethanol water, propylene glycol, acetone and their aqueous solution.
4, antipruritic varnish as claimed in claim 1 is characterized in that, described varnish is liquid masking liquid, ointment, gel, cream.
5, antipruritic varnish as claimed in claim 1 is characterized in that described pruritus comprises that mosquito bite, red swelling of the skin are itched, senile skin pruritus, and tinea causes due to the fungus itches, atopic dermatitis and allergic skin pruritus.
6, the application of the described antipruritic varnish of claim 1 in preparation treatment tinea pedis medicine.
CNB2004100203820A 2004-08-30 2004-08-30 Local externally applied itch stopping garlic liniments Expired - Fee Related CN100488543C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CNB2004100203820A CN100488543C (en) 2004-08-30 2004-08-30 Local externally applied itch stopping garlic liniments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNB2004100203820A CN100488543C (en) 2004-08-30 2004-08-30 Local externally applied itch stopping garlic liniments

Publications (2)

Publication Number Publication Date
CN1628754A true CN1628754A (en) 2005-06-22
CN100488543C CN100488543C (en) 2009-05-20

Family

ID=34845688

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100203820A Expired - Fee Related CN100488543C (en) 2004-08-30 2004-08-30 Local externally applied itch stopping garlic liniments

Country Status (1)

Country Link
CN (1) CN100488543C (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104415212A (en) * 2013-08-27 2015-03-18 北京继开德铭医药科技有限公司 Application of composition of garlic total polysaccharide and sulfur-containing amino acid in resisting skin desquamation and itching
CN107198757A (en) * 2017-06-30 2017-09-26 康国军 It is a kind of to treat the Chinese herbal medicine fluid that brothers bacterium catches an illness
CN107519318A (en) * 2017-08-29 2017-12-29 宁波保税区攀峒信息科技有限公司 A kind of Chinese herbal medicine liquid for alleviating skin symptom
CN108434307A (en) * 2018-03-09 2018-08-24 新疆埃乐欣药业有限公司 Antipruritic anti-acne garlic ointment of inhibiting bacteria and diminishing inflammation and its preparation method and application
CN108635495A (en) * 2018-08-13 2018-10-12 谭绍江 Liquid is embrocated in a kind of external application after hornet bites

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104415212A (en) * 2013-08-27 2015-03-18 北京继开德铭医药科技有限公司 Application of composition of garlic total polysaccharide and sulfur-containing amino acid in resisting skin desquamation and itching
CN107198757A (en) * 2017-06-30 2017-09-26 康国军 It is a kind of to treat the Chinese herbal medicine fluid that brothers bacterium catches an illness
CN107519318A (en) * 2017-08-29 2017-12-29 宁波保税区攀峒信息科技有限公司 A kind of Chinese herbal medicine liquid for alleviating skin symptom
CN108434307A (en) * 2018-03-09 2018-08-24 新疆埃乐欣药业有限公司 Antipruritic anti-acne garlic ointment of inhibiting bacteria and diminishing inflammation and its preparation method and application
CN108635495A (en) * 2018-08-13 2018-10-12 谭绍江 Liquid is embrocated in a kind of external application after hornet bites

Also Published As

Publication number Publication date
CN100488543C (en) 2009-05-20

Similar Documents

Publication Publication Date Title
CN100346805C (en) Xanthoceras sorbifolia bunge shell extract for treating cerebral hypofunction and anti-diabetic activity
CN101062289A (en) External application medicine combination for treating gout
CN112190593B (en) Polysaccharide composition for inhibiting TRPV1 pathway and preparation method and application thereof
CN105395919A (en) Composition containing black fungus extract and having effect of reducing blood fat and preparation method of composition
CN113018202A (en) Dendrobium officinale polysaccharide/astragalus polysaccharide composite hydrogel as well as preparation method and application thereof
CN101933965A (en) Mugwort extract and preparation process thereof, and application in controlling postmeal gucose
CN100488543C (en) Local externally applied itch stopping garlic liniments
CN104306732A (en) A roxburgh anoectochilus terminal bud-dendrobium officinale soft capsule and a preparing method thereof
CN103565686A (en) Permanent plant hair dye and preparation method thereof
CN101721543A (en) Pure traditional Chinese medicine lotion for treating gynecological diseases
CN101972284B (en) Preparation method of pine needle fat soluble extract and application thereof in preparing drug for treating gastric ulcer
CN1611232A (en) Medicinal composition with main effect of antifatigue, radioresistance and melancholia-resistance and its preparing method
CN100455300C (en) Compound wild kiwi tablet and its preparing method
CN107412393B (en) Preparation method and application of clausena lansium leaf polyphenol extract
CN1418674A (en) Medicine compositions for treating acne, and its prepn. method
CN111543638A (en) Sea cucumber polysaccharide product with auxiliary blood sugar reducing effect and preparation method thereof
CN111700927A (en) Medicinal and edible composition with blood sugar reducing effect and preparation method and application thereof
CN101062283A (en) Tea for reducing blood sugar and its preparing method
CN1302792C (en) Medicine composition with the action of relieving alcoholism and protecting liver and its application
CN1261111C (en) Jinyukang-oral medicine for curing depression
CN1237998C (en) Effervescence tablet for treating children's cough and asthma and its preparation
CN104474103A (en) Natural plant hypoglycemic agent and preparation method thereof
CN1120952A (en) Cosmetic with fuction of curing scar and acne and its preparation method
CN109718320B (en) Functional beverage for reducing uric acid
CN114931214B (en) Chinese herbal medicine composition for improving hearing impairment and preparation method and application thereof

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: TIANJIN QINGSONG MEDICINE TECHNOLOGY CO., LTD.

Free format text: FORMER OWNER: WANG ZHUAN JIAN

Effective date: 20080418

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20080418

Address after: Xikang Road Heping District, Tianjin city Chinese No. 72-74 Yunxiang Building 29 post encoding: 300074

Applicant after: Tianjin Qingsong Pharmaceutical Technology Co.,Ltd.

Address before: Tianjin City, Nankai District Yuquanlu Road No. 5 4-403 post Chamaecyparis pisifera encoding: 300193

Applicant before: Wang Chuanjian

C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: TIANJIN HUAYAO PHARMA CO., LTD

Free format text: FORMER OWNER: GREENPINE (TIANJIN) PHARMA CO., LTD.

Effective date: 20110402

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: 300074 29/F, YUNXIANG BUILDING, NO. 72-74, XIKANG ROAD, HEPING DISTRICT, TIANJIN CITY, CHINA TO: 300074 29/F, YUNXIANG BUILDING, NO. 72-74, XIKANG ROAD, HEPING DISTRICT, TIANJIN CITY

TR01 Transfer of patent right

Effective date of registration: 20110402

Address after: Xikang Road Heping District of Tianjin city in 300074 72-74, Yunxiang 29 storey building

Patentee after: TIANJIN HUAYAO PHARMACEUTICAL Co.,Ltd.

Address before: Xikang Road Heping District, Tianjin city 300074 China No. 72-74 Yunxiang Building 29

Patentee before: Tianjin Qingsong Pharmaceutical Technology Co.,Ltd.

ASS Succession or assignment of patent right

Owner name: TIANJIN GREENPINE CHINESE MEDICINE PHARMACEUTICAL

Free format text: FORMER OWNER: TIANJIN HUAYAO PHARMA CO., LTD

Effective date: 20120918

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20120918

Address after: Xikang Road Heping District of Tianjin city in 300074 72-74, Yunxiang 29 storey building

Patentee after: TIANJIN GREENPINE CHINESE MEDICINE PHARMACEUTICAL CO.,LTD.

Address before: Xikang Road Heping District of Tianjin city in 300074 72-74, Yunxiang 29 storey building

Patentee before: Tianjin Huayao Pharmaceutical Co.,Ltd.

CP03 Change of name, title or address
CP03 Change of name, title or address

Address after: No.16, LingHang Road, Tianjin Binhai New Area pilot free trade zone (Airport Economic Zone), 300450

Patentee after: Qingsong Pharmaceutical Group Co.,Ltd.

Address before: 300074 29th floor, Yunxiang building, 72-74 Xikang Road, Heping District, Tianjin

Patentee before: TIANJIN GREENPINE CHINESE MEDICINE PHARMACEUTICAL Co.,Ltd.

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090520