CN1626145A - Medication for treating cough - Google Patents
Medication for treating cough Download PDFInfo
- Publication number
- CN1626145A CN1626145A CN 200310107304 CN200310107304A CN1626145A CN 1626145 A CN1626145 A CN 1626145A CN 200310107304 CN200310107304 CN 200310107304 CN 200310107304 A CN200310107304 A CN 200310107304A CN 1626145 A CN1626145 A CN 1626145A
- Authority
- CN
- China
- Prior art keywords
- adjuvant
- bulbus fritillariae
- medicine
- mentholum
- starch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
A medicine for treating cough is disclosed. Its advantages are high safety and lower toxic by-effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the preparation of the raw material treatment cough of making.
Background technology
Cough is the multiple disease that a kind of coverage rate is wide, harm is bigger.And owing to the cough of catching a cold and bronchitis causes reaches more than several hundred million person-times every year.According to the statistics made by the departments concerned, the frequency of China's flu is: the adult suffers from 3-4 time every year approximately, and children's suffers from 6 every year approximately, and annual morbidity sum is more than billions of person-times.The characteristics of cough are airway obstruction or hypersecretion, when breathe stepping serious the obstruction, and patient's complication such as acutely might causing pulmonary heart disease of coughing, serious harm patient's body health influences quality of life of people.
In the market in the cough-relieving medicine of Xiao Shouing, no matter Chinese medicine, Western medicine mostly are dosage forms such as syrup, tablet and capsule greatly.Exist the sugar content height, dosage is big, take and carry inconvenience and certain shortcomings such as toxic and side effects are arranged, the cough medicine of Western medicine all has different untoward reaction with the expectorant major part, the synthetic chemical substance that modern medicine is commonly used has spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past to cough tendril-leaved fritillary bulb loquat drop pills as controlling of Tianjin Chinese medicine six factories production, have: three little triple effect five convenience " characteristics; but also face following problem at present: 1; drop pill adjuvant pure natural degree is not high: at present; drop pill substrate adjuvant mostly is synthetic; natural degree is lower; the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that its Chinese medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of medicine or abnormal smells from the patient and abandon the treatment of medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The purpose of this invention is to provide a kind of medicine of coughing with the treatment of new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of cough pharmaceutical preparation.
Be monarch drug with the Folium Eriobotryae among the present invention, the Folium Eriobotryae bitter in the mouth is cold in nature, and delicate fragrance is not dry.Can lung moistening relieve inflammation or internal heat, lowering the adverse-rising QI to resolve phlegm, cough-relieving is coughed surely, gets its lung heat clearing away, sputum eliminating, and the merit of making lung-QI pure and descending is to control the disease of expectorant heat stagnation lung.Compendium of Material Medica is said: " Folium Eriobotryae is controlled the disease of lung stomach, mostly gets the merit ear of its therapeutic method to keep the adverse QI flowing downwards.It is suitable that expectorant falls in the next fire of gas, and contrary person is not contrary, and the habitual vomiter does not vomit, and thirsty person is not thirsty.The person of coughing or not." " Bencao Congxin " also carries it that " lung heat clearing gas is arranged.Lung qi falls.Relieving cough and resolving phlegm " effect.Pathogenic heat is violated lung, the phlegm stagnancy QI rising in reverse order cough card, when being led, so think monarch by it.Minister is with Rhizoma pinelliae cordatae, Bulbus Fritillariae Uninbracteatae, to help the power of Folium Eriobotryae expelling phlegm for arresting cough.The hot temperature of Rhizoma pinelliae cordatae is and dry, and this is the key medicine of drying dampness to eliminate phlegm, warming for resolving cold-phlegm, the outstanding kind damp-phlegm of controlling internal organs.And Bulbus Fritillariae Uninbracteatae then has the effect of Qinghua heat-phlegm, nourishing the lung to arrest cough.Institute says as " book on Chinese herbal medicine justice ": " Rhizoma Pinelliae, Bulbus Fritillariae Uninbracteatae.All control phlegmatic cough.But the solely kind clearing heat in the lung of the double spleen lung of controlling of the Rhizoma Pinelliae, Bulbus Fritillariae Uninbracteatae: its suffering of the Rhizoma Pinelliae, Bulbus Fritillariae Uninbracteatae is used its hardship; Its temperature of the Rhizoma Pinelliae, Bulbus Fritillariae Uninbracteatae is used its cold; Rhizoma Pinelliae speed, Bulbus Fritillariae Uninbracteatae property is slow." the two mutually 5, usefulness mutually each other, the power of controlling phlegm-damp is special.Subtract and the suffering of Rhizoma pinelliae cordatae is dry.Assistant is let out with the hot hardship of loosing of Radix Platycodonis, and a surname opens lung qi, and promoting the circulation of QI reduces phlegm.Radix Platycodonis is the medicine of ascending lung qi, with Folium Eriobotryae one rise and one drop, both must rise in order to do clearing heat in QI system, and foul smell descends from gram, and then lung qi is declared respectful proper; Compatibility is with the product of the hot cold of book lotus brain in the side, and Mentholum one can be evacuated pathogenic factor in the exterior.Opening lung-energy can be gone into lung again with cough-relieving.Say as " book on Chinese herbal medicine is looked for the truth ": " thinking the energy that a surname's wind direction is led " with this, so making for full side.
The selected substrate adjuvant of the present invention is resulting by a large amount of tests, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is low, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.
The consumption of drug component of the present invention and the selection of adjuvant thereof also grope to sum up to draw through the inventor in a large number, each component raw material survival dose all has curative effect preferably in following ranges: Folium Eriobotryae 20～120g, the Rhizoma Pinelliae 8～35g, Bulbus Fritillariae Cirrhosae extract 1～25ml, Radix Platycodonis 2～12g, Mentholum 0.05～0.3g, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; The consumption of preferred drug component of the present invention and adjuvant thereof are that Folium Eriobotryae 55～75g, the Rhizoma Pinelliae 15～25g, Bulbus Fritillariae Cirrhosae extract 2～10ml, Radix Platycodonis 5～7g, Mentholum 0.1～0.2g, appropriate amount of auxiliary materials are made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; The consumption of best drug component of the present invention and adjuvant thereof are that Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae fluid extract 7ml, Mentholum 0.15g, appropriate amount of auxiliary materials are made, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Rhizoma Pinelliae the best in the foregoing invention is a Rhizoma pinelliae cordatae, and Bulbus Fritillariae Uninbracteatae the best is a Bulbus Fritillariae Ussuriensis.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters, preferred heating and melting temperature is 58～85 ℃, dripping the system temperature is 58～85 ℃, condensing agent is liquid paraffin, methyl-silicone oil, the condensing agent temperature is 0～18 ℃, the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 62～68 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0～8 ℃ methyl-silicone oil to 62～68 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than being the scope that allows on the galenic pharmacy, and medicine described here can be that crude drug also can be the effective ingredient extract.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a) get Folium Eriobotryae 20～120g, the Rhizoma Pinelliae 8～35g, Bulbus Fritillariae Uninbracteatae 1～25g, Radix Platycodonis 2～12g, Mentholum 0.05～0.3g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 50～95% ethanol, dipping, slowly percolation is collected the liquid 1～25ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 1～15ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 1～4 hour for the first time, 1～3 hour for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in appropriate amount of auxiliary materials, add above-mentioned standby extractum, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred manufacturing procedure comprises the following steps:
(a) get Folium Eriobotryae 55～75g, the Rhizoma Pinelliae 15～25g, Bulbus Fritillariae Uninbracteatae 2～10g, Radix Platycodonis 5～7g, Mentholum 0.1～0.2g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 60～85% ethanol, dipping, slowly percolation is collected the liquid 1～12ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 2～10ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2～3 hours for the first time, 1.5～2.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in appropriate amount of auxiliary materials, add above-mentioned standby extractum, fully mix, mixture is at 58～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 58～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, make drop pill, promptly.
Best preparation method comprises the following steps:
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae 7g, Mentholum 0.15g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in appropriate amount of auxiliary materials, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make drop pill, promptly.
The best preparation method of medicine of the present invention is:
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g, Mentholum 0.15g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Ussuriensis fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) be 1: 0.2～1: 0.3 xylitol and starch mixture to ratio an amount of, weight; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is to add above-mentioned standby extractum in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make drop pill, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, and efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis substrate adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of drop pill taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that cough is treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill that this adjuvant is made can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
The present invention is under instruction of Chinese Medicine theory, preparation technology's test that process is a large amount of and pharmacology, the resulting preparation of pharmacodynamics test.The present invention is evident in efficacy, and the effect of have cough-relieving, Dingchuan, eliminating the phlegm is used for the treatment of chronic bronchitis, asthmatic bronchitis, the caused cough of flu clinically.Poisonous side effect of medicine of the present invention is low, it is bigger to have overcome western medicine cough toxic and side effects, the Chinese medicine curative effect is low, flavour of a drug are many, the shortcoming of incompatibility large-scale production, in addition, the food adjuvant that this substrate adjuvant is a kind of excellent taste, can reduce the penetrating odor of medicine, improve the medicine mouthfeel, be the medicine of the treatment cough determined of a kind of economy, material benefit, curative effect.
In order to understand the present invention better, control with new substrate below and cough fritillary-loquat and drip and take the Polyethylene Glycol as test explanation advantages of the present invention such as controlling of making of substrate adjuvant dissolve scattered time limit, the ball method of double differences of coughing tendril-leaved fritillary bulb loquat drop pills are different, drop pill soft durometer, the sticking balls of drop pill.
Test example 1: dissolve scattered time limit, the different contrast experiment's example of the ball method of double differences
In vitro tests
The present invention be that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills and compared with the Polyethylene Glycol, by measuring dissolve scattered time limit, investigate its good releasing effect; By measuring indexs such as the ball method of double differences is different, whether ripe, whether be fit to suitability for industrialized production if investigating its preparation technology.
1. test medication: the new substrate of the present invention is controlled and is coughed tendril-leaved fritillary bulb loquat drop pills (newly), is that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills (old) with the Polyethylene Glycol.
2. method and result:
Dissolve scattered time limit: by " method is measured under this item of Chinese pharmacopoeia; The ball method of double differences is different: by " method is measured under this item of Chinese pharmacopoeia.Result of the test sees Table 1.
Three batches in table 1 is coughed tendril-leaved fritillary bulb loquat drop pills (newly) with controlling of making of new medium adjuvant and is that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills (old) dissolve scattered time limit, weight differential relatively with the polyethylene glycol 6000
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ??1′52″ ????4′55″ | ??1′52″ ????4′55″ | ??1′56″ ????4′56″ | ??1′56″ ????4′58″ | ??1′58″ ????4′58″ | ??1′57″ ????4′59″ | ??2′0″ ????5′0″ | |
| 2 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ??1′51″ ????4′53″ | ??1′53″ ????4′53″ | ??1′53″ ????4′55″ | ??1′55″ ????4′56″ | ??1′58″ ????4′58″ | ??1′57″ ????4′58″ | ??1′59″ ????4′59″ | |
| 3 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ??1′52″ ????4′53″ | ??1′52″ ????4′53″ | ??1′53″ ????4′55″ | ??1′54″ ????4′56″ | ??1′56″ ????4′56″ | ??1′59″ ????4′58″ | ??1′59″ ????4′59″ |
Test data shows, it is that controlling of making of adjuvant coughed lacking of tendril-leaved fritillary bulb loquat drop pills with the Polyethylene Glycol that new substrate is controlled the dissolve scattered time limit of coughing tendril-leaved fritillary bulb loquat drop pills, and new and old substrate is made controls that the ball method of double differences of coughing tendril-leaved fritillary bulb loquat drop pills is different all to be controlled in the pharmacopeia prescribed limit.Presentation of results, with novel adjuvant make to control the molten diffusing speed of coughing tendril-leaved fritillary bulb loquat drop pills faster, be more conducive to medicine and play a role, the different not statistically significant of the ball method of double differences, suitability for industrialized production greatly in the shortest time.
Test example 2: the present invention be that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills soft durometer, the sticking ball comparative observation of drop pill with the polyethylene glycol 6000
The present invention be that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills and compared with the Polyethylene Glycol, by measuring indexs such as above-mentioned, investigate its effect.
1. test medication: the new substrate of the present invention is controlled and is coughed tendril-leaved fritillary bulb loquat drop pills (newly), is provided by the Jinshili Medicine Research ﹠. Development Co., Ltd., Tianjin; Be that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills (old) with the Polyethylene Glycol, commercially available.
2. method and result:
Get new, old substrate and control and cough three batches of tendril-leaved fritillary bulb loquat drop pills, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that controlling of making of adjuvant coughed the tendril-leaved fritillary bulb loquat drop pills reserved sample observing relatively with the polyethylene glycol 6000
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly | |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 2 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 3 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
Table 2.2: cough tendril-leaved fritillary bulb loquat drop pills (newly) with controlling of making of new medium adjuvant and be that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills (old) character observation relatively with the polyethylene glycol 6000 for three batches
| 0 month | January | February | March | June | December | 18 months | ||
| Criterion | The result | |||||||
| 1 batch | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | Hard slightly (old) be hard (newly) slightly | |
| 2 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 3 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
Test data shows, new substrate is controlled and coughed the tendril-leaved fritillary bulb loquat drop pills soft durometer and change to the Polyethylene Glycol to be that controlling of making of adjuvant coughed tendril-leaved fritillary bulb loquat drop pills similar, strong slightly; New substrate is controlled the sticking ball variation of the drop pill of coughing tendril-leaved fritillary bulb loquat drop pills, firmness change and is that controlling of making of adjuvant coughed the similar of tendril-leaved fritillary bulb loquat drop pills with the Polyethylene Glycol.Presentation of results, new and old substrate adjuvant is made controls that the sticking ball of coughing tendril-leaved fritillary bulb loquat drop pills changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1
(a) get Folium Eriobotryae 20g, Rhizoma Pinelliae 8g, Bulbus Fritillariae Uninbracteatae 3g, Radix Platycodonis 2g, Mentholum 0.05g, xylitol 21.6g, starch 4.4g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 95% ethanol, dipping, slowly percolation is collected the liquid 1～4ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 2ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and starch mixture, add above-mentioned standby extractum, fully mix, mixture stirs at 90～115 ℃ of heating and meltings, and mixing time is 3 minutes, insulation, in following system of 50～55 ℃ of temperature, the dropper bore is 4.0 millimeters, splashes in 5 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 2
(a) get Folium Eriobotryae 120g, Rhizoma Pinelliae 35g, Bulbus Fritillariae Uninbracteatae 25g, Radix Platycodonis 12g, Mentholum 0.3g, lactose 12g, starch 3g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 50% ethanol, dipping, slowly percolation is collected the liquid 20～25ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 25ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 4 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in lactose and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 85～90 ℃ of heating and meltings, stir, mixing time is 10 minutes, insulation, at 60～65 ℃ of temperature following system, dropper bore is 1.2 millimeters, splash in-20～25 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 3
(a) get Folium Eriobotryae 120g, Rhizoma Pinelliae 8g, Bulbus Fritillariae Uninbracteatae 20g, Radix Platycodonis 2g, Mentholum 0.2g, xylitol 15g, arabic gum 5g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 60% ethanol, dipping, slowly percolation is collected the liquid 2～20ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 20ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 3.5 hours for the first time, 2.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and arabic gum mixture, add above-mentioned standby extractum, fully mix, mixture is at 70～85 ℃ of heating and meltings, stir, mixing time is 8 minutes, insulation, at 65～75 ℃ of temperature following system, dropper bore is 1.20～2.0 millimeters, splash in 0～5 ℃ the vegetable oil, make 1000 drop pill, promptly.
Embodiment 4
(a) get Folium Eriobotryae 55g, Rhizoma Pinelliae 15g, Bulbus Fritillariae Uninbracteatae 10g, Radix Platycodonis 7g, Mentholum 0.2g, xylitol 20.5g, xanthan gum 5.5g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 85% ethanol, dipping, slowly percolation is collected the liquid 1～12ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 10ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and xanthan gum mixtures, add above-mentioned standby extractum, fully mix, mixture is at 80～85 ℃ of heating and meltings, stir, mixing time is 15 minutes, insulation, at 70～80 ℃ of temperature following system, dropper bore is 1.1～1.5 millimeters, splash in 0～18 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 5
(a) get Folium Eriobotryae 75g, Rhizoma Pinelliae 15g, Bulbus Fritillariae Uninbracteatae 2g, Radix Platycodonis 7g, Mentholum 0.1g, sorbitol 23.6g, chitin 3.5g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 60% ethanol, dipping, slowly percolation is collected the liquid 1～4ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 2ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 3 hours for the first time, 2.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in sorbitol and chitin mixture, add above-mentioned standby extractum, fully mix, mixture is at 58～65 ℃ of heating and meltings, stir, mixing time is 30 minutes, insulation, at 58～65 ℃ of temperature following system, dropper bore is 3.5 millimeters, splash in 0～15 ℃ the liquid paraffin, make 1000 drop pill, promptly.
Embodiment 6
(a) get Folium Eriobotryae 55g, Rhizoma Pinelliae 25g, Bulbus Fritillariae Uninbracteatae 10g, Radix Platycodonis 7g, Mentholum 0.2g, xylitol 15.3g, starch 4.7g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 75% ethanol, dipping, slowly percolation is collected the liquid 1～12ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 10ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 78～85 ℃ of heating and meltings, stir, mixing time is 20 minutes, insulation, at 58～60 ℃ of temperature following system, dropper bore is 2.8 millimeters, splash in 0～5 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 7
(a) get Folium Eriobotryae 250g, Rhizoma Pinelliae 35g, Bulbus Fritillariae Uninbracteatae 55g, Radix Platycodonis 35g, Mentholum 0.4g, xylitol 480g, alginic acid 145g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 65% ethanol, dipping, slowly percolation is collected the liquid 35～55ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 55ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 3 hours for the first time, 2.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and alginic acid mixture, add above-mentioned standby extractum, fully mix, mixture is at 58～68 ℃ of heating and meltings, stir, mixing time is 50 minutes, insulation, at 60～65 ℃ of temperature following system, dropper bore is 3.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 1000g drop pill, promptly.
Embodiment 8
(a) get Folium Eriobotryae 350g, Rhizoma Pinelliae 55g, Bulbus Fritillariae Uninbracteatae 55g, Radix Platycodonis 55g, Mentholum 0.3g, xylitol 500g, starch 100g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 75% ethanol, dipping, slowly percolation is collected the liquid 35～55ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 55ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2 hours for the first time, 2.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 58～60 ℃ of heating and meltings, stir, mixing time is 120 minutes, insulation, at 58～60 ℃ of temperature following system, dropper bore is 3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, make the 1000g drop pill, promptly.
Embodiment 9
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma Pinelliae 20g, Bulbus Fritillariae Uninbracteatae 7g, Mentholum 0.15g, xylitol 16.6g, starch 3.4g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 10
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae 7g, Mentholum 0.15g, xylitol 14.3g, arabic gum 5.7g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and arabic gum mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 11
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae 7g, Mentholum 0.15g, lactose 15.4g, starch 4.6g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in lactose and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 12
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae 7g, Mentholum 0.15g, isomalt 18.2g, tragakanta 1.8g, standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 75% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in isomalt and tragakanta mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 13
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis 7g, Mentholum 0.15g, xylitol 20g, cyclodextrin 5g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 4 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Ussuriensis fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in cyclodextrin and xylitol blend, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 14
(a) get Folium Eriobotryae 300g, Rhizoma Pinelliae 45g, Bulbus Fritillariae Uninbracteatae 45g, Radix Platycodonis 45g, Mentholum 0.34g, xylitol 625g, starch 125g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Cirrhosae 45g, be ground into coarse powder,, make solvent with 70% ethanol according to the method under pharmacopeia appendix IO fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid 38ml that just filters, in addition device is preserved, and continues percolation, treats that soluble component filters out fully, be concentrated into an amount of, after adding the liquid mixing of just filtering, continue to be concentrated into 45ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 1000g drop pill, promptly.
Embodiment 15
(a) get Folium Eriobotryae 300g, Rhizoma Pinelliae 45g, Bulbus Fritillariae Uninbracteatae 45g, Radix Platycodonis 45g, Mentholum 0.34g, xylitol 680g, Arabic 170g glue is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Cirrhosae 45g, be ground into coarse powder,, make solvent with 70% ethanol according to the method under pharmacopeia appendix IO fluid extract and the extractum item, flood after 5 days, slowly percolation is collected the liquid 38ml that just filters, in addition device is preserved, and continues percolation, treats that soluble component filters out fully, be concentrated into an amount of, after adding the liquid mixing of just filtering, continue to be concentrated into 45ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Uninbracteatae fluid extract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in xylitol and arabic gum mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 1000g drop pill, promptly.
Embodiment 16
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis fluid extract 7ml, Mentholum 0.15g, xylitol 17.5g, starch 3.5g are standby;
(b) the above five tastes except that Mentholum, Bulbus Fritillariae Ussuriensis fluid extract, are got all the other Radix Platycodonis three flavors and are decocted with water secondary, 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with the Bulbus Fritillariae Ussuriensis fluid extract, put coldly, add Mentholum, stir, make standby extractum;
(c) in xylitol and starch mixture, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 17
Get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis fluid extract 7ml, Mentholum 0.15g, lactose 25g, starch 5g are standby
The above five tastes are got Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae and are decocted with water secondary, filter, merging filtrate is concentrated in right amount, adds Bulbus Fritillariae Ussuriensis fluid extract and Mentholum, add in xylitol and the starch mixture, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Embodiment 18
Get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Ussuriensis fluid extract 7ml, Mentholum 0.15g, xylitol 21.5g, starch 4.5g are standby
The above five tastes are got Folium Eriobotryae, Radix Platycodonis, Rhizoma pinelliae cordatae and are decocted with water secondary, filter, merging filtrate is concentrated in right amount, adds Bulbus Fritillariae Ussuriensis fluid extract and Mentholum, add in xylitol and the starch mixture, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make 1000 drop pill, promptly.
Claims (14)
1, a kind of medicine for the treatment of cough, it is characterized in that it mainly is by Folium Eriobotryae 20～120g, the Rhizoma Pinelliae 8～35g, Bulbus Fritillariae Cirrhosae extract 1～25ml, Radix Platycodonis 2～12g, Mentholum 0.05～0.3g, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2, the medicine of treatment cough as claimed in claim 1, it is characterized in that it is to be made by Folium Eriobotryae 55～75g, the Rhizoma Pinelliae 15～25g, Bulbus Fritillariae Cirrhosae extract 2～10ml, Radix Platycodonis 5～7g, Mentholum 0.1～0.2g, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, the medicine of treatment cough as claimed in claim 1 or 2, it is characterized in that it is to be made by Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae fluid extract 7ml, Mentholum 0.15g, appropriate amount of auxiliary materials, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
4, as the medicine of claim 1,2 or 3 described treatment coughs, it is characterized in that the Rhizoma Pinelliae wherein can be a Rhizoma pinelliae cordatae, Bulbus Fritillariae Uninbracteatae can be a Bulbus Fritillariae Ussuriensis.
5, the medicine of coughing as claim 1,2 or 3 described treatments, it is characterized in that it can also contain chemosynthesis adjuvant and animal origin adjuvant in above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
6, the medicine of treatment cough as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
7, the medicine of treatment cough as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
8, the medicine of treatment cough as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
9, as the medicine of claim 1,2 or 3 described treatment coughs, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 1.
10, as the medicine of claim 1,2 or 3 described treatment coughs, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 0.6.
11, as the medicine of claim 1,2 or 3 described treatment coughs, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2～1: 0.4.
12, the preparation method of the medicine of claim 1,2 or 3 described treatment coughs is characterized in that this method comprises the steps:
(a) get Folium Eriobotryae 20～120g, the Rhizoma Pinelliae 8～35g, Bulbus Fritillariae Uninbracteatae 1～25g, Radix Platycodonis 2～12g, Mentholum 0.05～0.3g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 50～95% ethanol, dipping, slowly percolation is collected the liquid 1～25ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 1～15ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 1～4 hour for the first time, 1～3 hour for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with Bulbus Fritillariae Cirrhosae fluidextract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in appropriate amount of auxiliary materials, add above-mentioned standby extractum, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
13, the preparation method of the medicine of treatment cough as claimed in claim 12 is characterized in that this method comprises the steps:
(a) get Folium Eriobotryae 55～75g, the Rhizoma Pinelliae 15～25g, Bulbus Fritillariae Uninbracteatae 2～10g, Radix Platycodonis 5～7g, Mentholum 0.1～0.2g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 60～85% ethanol, dipping, slowly percolation is collected the liquid 1～12ml that just filters, and device is preserved in addition, continue percolation, treat that soluble component filters out fully, be concentrated in right amount, add after the liquid of just filtering mixes, continue to be concentrated into 2～10ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2～3 hours for the first time, 1.5～2.5 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with Bulbus Fritillariae Cirrhosae fluidextract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in appropriate amount of auxiliary materials, add above-mentioned standby extractum, fully mix, mixture is at 58～85 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 58～85 ℃ of temperature following system, dropper bore is 1.1～3.5 millimeters, splash in 0～18 ℃ the liquid paraffin, methyl-silicone oil, make drop pill, promptly.
14, the preparation method of the medicine of treatment cough as claimed in claim 12 is characterized in that this method comprises the steps:
(a) get Folium Eriobotryae 68g, Radix Platycodonis 6g, Rhizoma pinelliae cordatae 20g, Bulbus Fritillariae Uninbracteatae 7g, Mentholum 0.15g is standby;
(b) the above five tastes except that Mentholum, are got Bulbus Fritillariae Uninbracteatae and are ground into coarse powder, according to the method under pharmacopeia appendix IO fluid extract and the extractum item, make solvent with 70% ethanol, flood after 5 days, slowly percolation is collected the liquid 4～10ml that just filters, and device is preserved in addition, continue percolation, the soluble component of waiting is filtered out fully, is concentrated in right amount, and adding is just filtered after the liquid mixing, continue to be concentrated into 7ml, filter; All the other Radix Platycodoniss three flavors decoct with water secondary, and 2.5 hours for the first time, 2 hours for the second time, collecting decoction, filtrate is concentrated in right amount, mixes with Bulbus Fritillariae Cirrhosae fluidextract, puts coldly, and the adding Mentholum stirs, and makes standby extractum;
(c) in appropriate amount of auxiliary materials, add above-mentioned standby extractum, fully mix, mixture is at 62～68 ℃ of heating and meltings, stir, mixing time is 10～30 minutes, insulation, at 62～68 ℃ of temperature following system, dropper bore is 1.2～2.5 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make drop pill, promptly.
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| CNB200310107304XA CN100455314C (en) | 2003-12-11 | 2003-12-11 | Medication for treating cough |
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| CNB200310107304XA CN100455314C (en) | 2003-12-11 | 2003-12-11 | Medication for treating cough |
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| CN100455314C CN100455314C (en) | 2009-01-28 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101104025B (en) * | 2007-07-30 | 2011-10-19 | 徐萍儿 | Decoction medicine for treating cough caused by long-lasting diseases and preparation method |
| CN102406820A (en) * | 2011-11-08 | 2012-04-11 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of fritillary and loquat dripping pills for treating cough |
| CN102485257A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicinal composition with lung ventilating, stagnated qi dispersing, heat clearing and phlegm eliminating effects and its preparation method |
| CN102485256A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and preparation method thereof |
| CN102626483A (en) * | 2012-04-18 | 2012-08-08 | 广州潘高寿药业股份有限公司 | Application of Chinese medicinal composition to preparation of medicament for preventing and improving lung PM2.5 deposition |
| CN103083528A (en) * | 2011-11-08 | 2013-05-08 | 天津中新药业集团股份有限公司第六中药厂 | Tendril-leaved fritillary bulb loquat dropping pill for treating cough and preparation method |
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2003
- 2003-12-11 CN CNB200310107304XA patent/CN100455314C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101104025B (en) * | 2007-07-30 | 2011-10-19 | 徐萍儿 | Decoction medicine for treating cough caused by long-lasting diseases and preparation method |
| CN102485257A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicinal composition with lung ventilating, stagnated qi dispersing, heat clearing and phlegm eliminating effects and its preparation method |
| CN102485256A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and preparation method thereof |
| CN102485257B (en) * | 2010-12-03 | 2013-10-09 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicinal composition with lung ventilating, stagnated qi dispersing, heat clearing and phlegm eliminating effects and its preparation method |
| CN102485256B (en) * | 2010-12-03 | 2013-10-16 | 天津中新药业集团股份有限公司第六中药厂 | Chinese medicine composition for diffusing lung, depressing qi, clearing heat, and eliminating phlegm and preparation method thereof |
| CN102406820A (en) * | 2011-11-08 | 2012-04-11 | 天津中新药业集团股份有限公司第六中药厂 | Preparation method of fritillary and loquat dripping pills for treating cough |
| CN103083528A (en) * | 2011-11-08 | 2013-05-08 | 天津中新药业集团股份有限公司第六中药厂 | Tendril-leaved fritillary bulb loquat dropping pill for treating cough and preparation method |
| CN102626483A (en) * | 2012-04-18 | 2012-08-08 | 广州潘高寿药业股份有限公司 | Application of Chinese medicinal composition to preparation of medicament for preventing and improving lung PM2.5 deposition |
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| Publication number | Publication date |
|---|---|
| CN100455314C (en) | 2009-01-28 |
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Granted publication date: 20090128 Termination date: 20191211 |