CN1626141A - Medication for relieving cough and asthma - Google Patents
Medication for relieving cough and asthma Download PDFInfo
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- CN1626141A CN1626141A CN 200310107300 CN200310107300A CN1626141A CN 1626141 A CN1626141 A CN 1626141A CN 200310107300 CN200310107300 CN 200310107300 CN 200310107300 A CN200310107300 A CN 200310107300A CN 1626141 A CN1626141 A CN 1626141A
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- adjuvant
- starch
- medicine
- asthma
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Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A medicine for treating cough and asthma is disclosed. Its advantages are high safety and lower toxic by-effect.
Description
Technical field
The present invention relates to field of medicaments, particularly, relating to Chinese medicine is the preparation of the treatment wind and cold diseases caused by retention of fluid made of raw material, fever with aversion to cold, lossless, cough with asthma.
Background technology
XIAOQINGLONG TANG is the representative prescription of relieving the exterior syndrome with drugs of pungent in flavor and warm in nature that Zhang Zhongjing is created, and has the effect of the dissipating fluid-retention of inducing sweat, relieving cough and asthma.Be widely used in diseases such as wind and cold diseases caused by retention of fluid, fever with aversion to cold, lossless, cough with asthma thin sputum, determined curative effect, at present its improvement dosage form has the nineteen ninety-five version Pharmacopoeia of the People's Republic of China mixture and the electuary that record, its dosage form decoction is more in the past had large improvement, but still there are some defective in mixture and electuary, absorb by gastrointestinal as effective composition, liver first-pass effect etc. is arranged, influence the effect of medicine to a certain extent; Yunnan University of Traditional Chinese Medicine adopts orthogonal test to study the optimised process of XIAOQINGLONG TANG drop pill molding, and the employing polyethylene glycol 6000 is an adjuvant, makes drop pill.The synthetic chemical substance commonly used as modern medicine spreaded all over each corner of human lives, chemical synthetic drug becomes the main flow of medicine, yet, appearance along with multiple difficult serious symptom miscellaneous diseases, western medical treatment presents imperfect, the human lives and the healthy reality and the up-to-date successes achieved in research have all proposed query to this situation, particularly along with the continuous appearance of chemical drugs toxic and side effects, the change of spectrum of disease and conversion of medical, make modern medicine be subjected to unprecedented challenge, and people also place hope in the application and development of traditional medicine on gradually.Advocate back to nature, pay attention to plant amedica use, hanker after traditional remedies, the trend of advocating natural drug forms, making full use of natural materials is human best selections.
At present, in the world, natural drug all has certain market, along with people increasing and the aging of population to the health requirements level of understanding, sub-health stateization, people thirst for back to nature more, the problem of utilize the high Drug therapy of pure natural degree, preventing some chemical synthetic drugs cann't be solved, so the background that exceeds its original traditional national culture has been expanded in the application of natural plant.From natural drug, seek the little and inexpensive medicine of side effect and become the target that countries in the world pharmaceutical manufacturer is chased.The European Community has carried out unified legislation to medical herbs, state medical herbs status such as Canada and Australia have legalized, U.S. government has also drafted the plant amedica management method, the compound recipe mix preparation that begins to accept natural drug is as curative, and these provide good international environment for Chinese medicine enters international medical market as curative.On the other hand, along with the quickening of global economic integration progress, particularly China becomes a full member of WTO, and Chinese Medicine market incorporates the breadth and depth of international medical big market and will further aggravate.Face the enormous impact of Asian countries's traditional medicine product such as the keen competition of powerful transnational medical group and Japan, Korea S, India, Thailand and European countries' plant amedica such as Germany, France, numerous products that China's Chinese medicine produces are owing to still can not meet the standard of international medical market and requirement and being kept outside of the door.
Expansion and human back to nature requirement along with the market global range, use the low medicine of toxic and side effects, especially pure natural medical more and more becomes people's first-selection, dropping pill formulation be a kind of have efficient, quick-acting new medicine preparations, it has overcome the shortcoming and deficiency of Chinese medicine preparation in the past, but present dropping pill formulation generally faces following problem: 1, drop pill adjuvant pure natural degree is not high: at present, drop pill substrate adjuvant mostly is synthetic, natural degree is lower, the searching of new alternative substrate adjuvant, the searching of the alternative substrate adjuvant that particularly natural degree is high and preparation technology thereof determine, it is again very difficult thing, because the required preparation condition of at present common possible natural substrates adjuvant succedaneum is very harsh, it all is to influence the key that drop pill prepares molding that adjuvant temperature and drop pill thereof drip the system condition.The too high then viscosity of adjuvant melt temperature is low, and poor plasticity is though the adjuvant melt temperature is crossed lowplastcity by force, but drop pill has shortcomings such as easily sticking ball, distortion, therefore, seek pure natural degree height, and the adjuvant that is suitable for substituting existing drop pill substrate is a very job of hardships.2, the drop pill outlet encounters problems: along with expanding economy, more and more internationalize in market, China is also just making great efforts to adapt to this trend, present Chinese medicine dripping pills preparation as health food, successful export to many countries, but also face many problems at present, because different countries is different to the approval of the selected adjuvant of Chinese medicine dropping pill formulation, especially industrial flourishing Europe, more strict to food adjuvant and medical auxiliary materials, and as the selected chemosynthesis adjuvant (as Polyethylene Glycol) of the dropping pill formulation of health food outlet not in the catalogue of some national food additive, it is very unfavorable that this moves towards the international market to the Chinese medicine dropping pill formulation, becomes the stumbling-block that Chinese medicine enters the international market, therefore, seek the new of one or more, can be particularly important, also very urgent for the substrate adjuvant that the international market is accepted.3, the shortcoming of mouthfeel and onset speed: the mouthfeel of Chinese medicine and preparation thereof is relatively poor to be the big characteristics of one, people when taking some drugs to the frightened of disagreeable taste that medicine had even be better than fear far away to disease, What is more, some patients are because can not overcome the poor taste of Chinese medicine or its preparation or abnormal smells from the patient and abandon the treatment of Chinese medicine, though can improve mouthfeel as medicine being made capsule or sugar coated tablet, reducing stimulates, but disintegration rate prolongs, be unfavorable for the rapid onset of medicine, to some disease, particularly need the disease of the rapid onset of medicine inapplicable.4, the preparation process difficulty of drop pill suitability for industrialized production: in the replacement process of dropping pill formulation adjuvant, determining of the preparation process of its suitability for industrialized production is very difficult something, as the ratio of the melt temperature of substrate adjuvant, the proportioning of dripping system temperature, adjuvant and medicine, dropper bore, condensing agent etc. all are the factors that influence drop pill, therefore, the replacement of substrate and to be suitable for suitability for industrialized production be a job consuming time, as to expend substantial contribution.
In order to change drop pill substrate adjuvant for a long time based on the situation of chemosynthesis adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and can not satisfy more and more that people require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect; Also can solve some problems that Chinese medicine preparation, particularly dropping pill formulation are run in exit procedure, strengthen the competitiveness of international market; The present invention has invented the pure Chinese medicine dripping pills preparation that a kind of toxic and side effects is low, evident in efficacy, moderate, adapt to industrialized great production by a large amount of tests and the research of preparation process.
Summary of the invention
The medicine that the purpose of this invention is to provide a kind of treatment cough with asthma with new type natural substrate adjuvant preparation.
Another object of the present invention provides a kind of preparation method for the treatment of cough with asthma pharmaceutical preparation.
It is resulting by a large amount of tests inventing selected substrate adjuvant, it is little to have molecular weight, soluble in water, and molten diffusing speed is faster, pure natural degree height, toxic and side effects is lower, and can reduce the medicine irritation abnormal smells from the patient, has the oral cavity of improvement acid-base value during the buccal of oral cavity, improve the characteristics of oral cavity smell, the used substrate adjuvant of the present invention is the agent of food sedan-chair flavor, takes that mouthfeel is good, the acceptant characteristics of patient, is the direction of following substrate adjuvant development.Medicine of the present invention is to invent on the basis of the little Green Dragon drop pill of XIAOQINGLONG TANG and Yunnan University of Traditional Chinese Medicine, to the prescription consumption, medicinal material extract technology, the consumption of adjuvant substrate, the drop pill moulding process has all carried out orthogonal test, drug component of the present invention, the selection of consumption and adjuvant thereof also gropes to sum up to draw through the inventor in a large number, each amounts of components all has curative effect preferably in following ranges: 60～200 parts in Herba Ephedrae, 60～200 parts of Ramulus Cinnamomi, 60～200 parts of the Radix Paeoniae Albas, 60～200 parts of Rhizoma Zingiberiss, 30～100 parts of Herba Asaris, 60～200 parts in Radix Glycyrrhizae, 90～270 parts of the Rhizoma Pinelliaes, 60～200 parts of Fructus Schisandrae Chinensis, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose; Preferred drug component consumption of the present invention and adjuvant thereof be chosen as 110～150 parts in Herba Ephedrae, 110～150 parts of Ramulus Cinnamomi, 110～150 parts of the Radix Paeoniae Albas, 110～150 parts of Rhizoma Zingiberiss, 50～80 parts of Herba Asaris, 110～150 parts in Radix Glycyrrhizae, 150～220 parts of the Rhizoma Pinelliaes, 110～150 parts of Fructus Schisandrae Chinensis, appropriate amount of auxiliary materials is made, filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose; Best drug component consumption of the present invention and adjuvant thereof be chosen as 125 parts in Herba Ephedrae, 125 parts of Ramulus Cinnamomi, 1125 parts of the Radix Paeoniae Albas, 125 parts of Rhizoma Zingiberiss, 62 parts of Herba Asaris, 125 parts in Radix Glycyrrhizae, 188 parts of the Rhizoma Pinelliaes, 125 parts of Fructus Schisandrae Chinensis, appropriate amount of auxiliary materials is made, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
Can also contain chemosynthesis adjuvant and animal origin adjuvant in the above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
In screening to above adjuvant, we find: plant colloid such as carrageenan, the tragakanta, pectin, agar, arabic gum, Ficus elastica, tamarind gum, locust bean gum, Pseudobulbus Bletillae (Rhizoma Bletillae) glue, guar gum, Konjac glucomannan, it is big that plant colloids such as POLY-karaya have viscosity, mobile poor, characteristics such as do not solidify after the condensation, and arabic gum has high dense low sticking character, can be mixed with the aqueous solution of 50% concentration and still have flowability, this is one of not available characteristics of other hydrophilic colloid, arabic gum has at high temperature, under the low concentration, can ooze, but not condensation, at low temperature, under the high concentration, be difficult for oozing, but characteristics such as energy condensation.Polysaccharide such as polysaccharide such as starch and derivant thereof (as gelling starch, carboxymethyl starch etc.), cellulose derivative (as methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose etc.), alginic acid, dextrin, cyclodextrin, lactose, in screening, find alginic acid have viscosity big, be the fruit jelly sample, dextrin has the colloid sample, characteristics such as lactose coagulability difference; And starch and derivant thereof are materials commonly used in the medical science adjuvant, thus in polysaccharide preferred starch and derivant thereof.Polyhydric alcohol such as sorbitol (88～102 ℃), xylitol (88～94.5 ℃), lactose (70～80 ℃), mannitol (166～169 ℃), maltose alcohol (135～140 ℃), isomalt polyhydric alcohol such as (98～103 ℃) screen, and find that it has following characteristics as drop pill substrate: sorbitol, lactose, isomalt are mobile poor; Mannitol, maltose alcohol fusing point are too high; The xylitol coagulability is poor slightly.After Preliminary screening, preferred xylitol, lactose, sorbitol in the selection of polyhydric alcohol, the best is an xylitol.Xylitol has following characteristics as drop pill substrate: in the time of 91 ℃, molten condition has appearred in xylitol, but not fusion fully, cooling rapidly, it separates out crystallization very soon, xylitol mixes the back good fluidity with extractum at certain proportion, can drip and can condensation, but be condensed into Powdered thing, loosely organized, the toughness extreme difference, that pinches is promptly broken.Organic acid and salt, alkali such as citric acid (100 ℃), sorbic acid (133 ℃), succinic acid (181～189 ℃), sodium acetate organic acid such as (58 ℃) and salt, alkali, its as drop pill substrate have fusing point too high, with Chinese medical concrete can't mixing etc. shortcoming.
Because of above single adjuvant existing shortcoming in as the drop pill preparation process, particularly we by above-mentioned Preliminary screening after, determine two kinds of adjuvants are used and screen: mainly be that above various adjuvants are carried out combined sorting, final determine following several: the plant colloid cooperates with the plant colloid, the cooperating of polyhydric alcohol and polyhydric alcohol, polyhydric alcohol and plant colloidally cooperate, the cooperating of the cooperating of xylitol and arabic gum, lactose and arabic gum, based on the composite auxiliary material of xylitol.Find preferred the cooperation to be xylitol, lactose and the compound use of other adjuvant, this kind combination has following characteristics: make up with mannitol: can drip not condensation; Make up with sorbic acid: both do not dissolve each other; Make up with lactose: can drip the energy condensation, but frangible; Make up with pomelo-pectin, tragakanta, sodium alginate: viscosity is big, can't drip; Make up with arabic gum: can drip, coagulability is poor slightly; Make up with dextrin: can drip, coagulability is poor slightly; Make up with starch: can drip, coagulability is also better.Determine that at last best of breed is that xylitol cooperates with arabic gum with starch, xylitol with starch, lactose.
At xylitol and starch, lactose and starch, in the research of xylitol and arabic gum combination, xylitol and starch Application of composite being prepared some required in the process of drop pill factors investigated, mainly is to the xylitol type, condensed fluid, condensate temperature influences the drop pill mouldability, xylitol and starch proportion influence mouldability, temperature is to the influence of drop pill mouldability, the extractum amount influences the drop pill mouldability, mixing time influences the drop pill mouldability, the dropper bore is to the influence of drop pill particle diameter, the formulation optimization of drop pill, the Preliminary Determination of drop pill, dissolve scattered time limit is investigated.Find that the solid xylitol has three types of powder, granular and crystallinity, and the easiest fusion of powder xylitol, again can fine dissolving be dispersed in the mixed liquor that starch, extractum forms, good fluidity, drippage is easy, and granular and crystalline xyhose alcohol is difficult for fusion, solubility property is also slightly poor, the mix flow that they and starch, extractum form is relatively poor, viscosity is very big, almost cannot drip, and therefore drips first-selected powder xylitol in the system process at drop pill.
At ratio of adjuvant molding is found in the sex research, in the combination of xylitol and starch, lactose and starch, xylitol and arabic gum, low melting point substrate adjuvant is 1: 0～1: 1.5 with the ratio of the weight of plasticity substrate adjuvant, be preferably 1: 0.1～1: 0.9, the best is 1: 0.1～1: 0.5.Low melting point substrate adjuvant of being formed within this scope and plasticity substrate adjuvant, the drug matrices fused solution all can ooze, and can condensation.Specific to each combination, xylitol is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and lactose is preferably 1: 0.2 with the ratio of the weight of starch～1: 0.3, and the ratio of the weight of xylitol and arabic gum is preferably 1: 0.2～and 1: 0.4.Find that in the research of temperature temperature is big especially to the influence of drop pill mouldability to the influence of drop pill mouldability, when temperature is too low, owing to the too big effect that oozes that influences drop pill of viscosity of substrate, when temperature is too high, not condensation of drop pill.Find that mixing time can have influence on the mouldability of drop pill in mixing time in to the sex research of drop pill molding, mixing time is too short, and mobile poor, influence oozes, and mixing time is oversize, influences the condensation of drop pill.Dripping under the system temperature, mixing time in 1～120 minute all can, suitable mixing time was at 10～30 minutes.Consider that mixing time can not be too short in the suitability for industrialized production, adopt the method that low temperature stirs for a long time, high temperature drips system.Find that in the research of dropper bore to the influence of drop pill particle diameter the dropper bore influences the size of drop pill and the flowability of fusion substrate, the system effect is dripped in influence.Drop pill diminishes and diminishes along with bore, but after 1.4 millimeters, along with the bore change of size that diminishes is not obvious, but the matrix flow reduction, system is dripped in influence.
So in the preparation method of preparation, medicine mixes mixing time with the substrate adjuvant be 10～30 minutes; The mixed heating and melting temperature of medicine and substrate adjuvant is 45～115 ℃, dripping the system temperature is 45～95 ℃, and liquid coolant is liquid paraffin, methyl-silicone oil or vegetable oil (Oleum Glycines, Semen Ricini wet goods), and the temperature of liquid coolant is-20～25 ℃, dropper mouth internal diameter is 1.0～4.0 millimeters; Preferred heating and melting temperature is 60～85 ℃, and dripping a system temperature is 60～85 ℃, and condensing agent is liquid paraffin, methyl-silicone oil, and the condensing agent temperature is 0～18 ℃, and the dropper bore is 1.1～3.5 millimeters, and the difference of dropper mouth external diameter and internal diameter is less for well; Best heating and melting temperature is that to make temperature be that 64 ℃, dropper bore are that 1.2～2.5 millimeters, condensing agent are 0 ℃ methyl-silicone oil to 64 ℃, droplet.
The substrate adjuvant of the best of the present invention is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be lactose and starch, lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch; Or be xylitol and arabic gum, the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
Xylitol is a kind of natural plant sweetening agent, approve through World Health Organization (WHO), xylitol is a kind of safest sweeting agent, countries in the world are extensive use of in fields such as food and oral-cavity articles, xylitol enters the help that need not insulin in the cell, when sugar utilizes obstacle, can not cause blood sugar increasing yet, can improve diabetics symptom, have the ketoplastic effect of powerful inhibition, can promote the generation of liver glycogen, directly infiltrate the Developmental and Metabolic Disorder that tissue is participated in metabolism, can be corrected protein, fat and steroid; Xylose is the internal metabolism intermediate product, and body has higher toleration to it.Clinical practice proves: the highest oral dosis tolerata can reach 220g every day, and intravenous drip every day can reach 100g.The oral 25700mg/Kg of median lethal dose(LD 50) (LD50) mice, quiet notes 6400mg/Kg, the quiet notes of rat 6200mg/Kg.
Medicine mesostroma adjuvant of the present invention and amount of drug are than can being the scope that allows on the galenic pharmacy, medicine described here can be that crude drug also can be the effective ingredient extract, in order to adapt to industrialized great production, the ratio range of mesostroma adjuvant of the present invention and medicine refers to the weight proportion of adjuvant and extract drugs extractum, and the substrate adjuvant is 1: 0.1～1: 1 with the ratio of the weight of drug extract; Preferred substrate adjuvant is 1: 0.1～1: 0.6 with the ratio of the weight of extract drugs extractum; Best substrate adjuvant is 1: 0.2～1: 0.4 with the ratio of the extraction extractum weight of medicine.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.The preparation of effective ingredient of the present invention can be adopted following method: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous backflow extraction method, macroreticular resin absorbing method preparation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also can be with these medicines decocting together, the condensed water decocting liquid is made oral liquid then; But, preferably adopt following technology to extract, but this can not limit protection scope of the present invention to raw material in order to make each crude drug of this medicine better bring into play drug effect.
The preparation method of medicine of the present invention is as follows:
(a) take by weighing 60～200 parts in Herba Ephedrae, 60～200 parts of Ramulus Cinnamomi, 60～200 parts of the Radix Paeoniae Albas, 60～200 parts of Rhizoma Zingiberiss, 30～100 parts of Herba Asaris, 60～200 parts in Radix Glycyrrhizae, 90～270 parts of the Rhizoma Pinelliaes, 60～200 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 3～10 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in crude drug 0.1～1: 0.1～1 amount, add equivalent ethanol, and after fully stirring, cold preservation 12～36 hours filters, and decompression filtrate recycling ethanol gets thick paste;
(c) in appropriate amount of auxiliary materials, add above-mentioned extractum and volatile oil, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
Preferred manufacturing procedure comprises the following steps:
(a) take by weighing 110～150 parts in Herba Ephedrae by proportioning raw materials, 110～150 parts of Ramulus Cinnamomi, 110～150 parts of the Radix Paeoniae Albas, 110～150 parts of Rhizoma Zingiberiss, 50～80 parts of Herba Asaris, 110～150 parts in Radix Glycyrrhizae, 150～220 parts of the Rhizoma Pinelliaes, 110～150 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 5～8 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 20～30 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c) in appropriate amount of auxiliary materials, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
Best preparation method comprises the following steps:
(a) take by weighing 125 parts in Herba Ephedrae by proportioning raw materials, 125 parts of Ramulus Cinnamomi, 125 parts of the Radix Paeoniae Albas, 125 parts of Rhizoma Zingiberiss, 62 parts of Herba Asaris, 125 parts in Radix Glycyrrhizae, 188 parts of the Rhizoma Pinelliaes, 125 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c) in appropriate amount of auxiliary materials, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
The best preparation method of medicine of the present invention is:
(a) take by weighing 125 parts in Herba Ephedrae by proportioning raw materials, 125 parts of Ramulus Cinnamomi, 125 parts of the Radix Paeoniae Albas, 125 parts of Rhizoma Zingiberiss, 62 parts of Herba Asaris, 125 parts in Radix Glycyrrhizae, 188 parts of the Rhizoma Pinelliaes, 125 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c) be 1: 0.2～1: 0.3 xylitol and starch mixture to ratio an amount of, weight; Or the ratio of weight is 1: 0.2～1: 0.3 lactose and starch mixture; Or the ratio of weight is to add above-mentioned extractum and volatile oil in 1: 0.2～1: 0.4 xylitol and the arabic gum mixture, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
More than each single medicinal material, especially adjuvant drug, messenger drug or adjuvant drug and messenger drug in forming, can be replaced by suitable Chinese medicine individually or simultaneously with the identical property of medicine, effect, it is constant to replace back Chinese medicine preparation and drug effect thereof.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The drop pill that the present invention is prepared, conventional drop pill advantage is simple as preparing except having, steady quality, can make liquid medicine solidification, convenient drug administration, efficient, quick-acting, its biggest advantage is:
1, the selected adjuvant pure natural of the present invention degree height: the substrate adjuvant that employed substrate adjuvant derives from natural plants or originates based on natural plants among the present invention, selected substrate adjuvant is xylitol and starch or lactose and starch or xylitol and arabic gum, this substrate adjuvant has pure natural degree height, toxic and side effects is low, mouthfeel is good, dissolve scattered time limit is short, rapid-action, it is a kind of new medium adjuvant, can be used for substituting present chemosynthesis adjuvant, the drop pill made from this kind adjuvant, it is low to solve the pure natural degree that present drop pill substrate faced, and more and more can not satisfy people and require back to nature, take low toxicity, the problem of the pure natural medical that has no side effect.
2, some problems in the outlet of solution Chinese medicine: medicine of the present invention also can solve Chinese medicine preparation, some problems of in exit procedure, being run into of dropping pill formulation particularly, solve because different countries, especially the European countries of industry prosperity are to the difference identification of the selected adjuvant of Chinese medicine dropping pill formulation, overcome as the selected adjuvant Polyethylene Glycol of the dropping pill formulation of the health food outlet defective in some national food additive catalogue not, improve the Chinese medicine dripping pills preparation and move towards the international market, strengthen the competitiveness of international market.
3, solve the relatively poor problem of dropping pill formulation taste and further improve drug effect speed (dissolve scattered time limit): the medicinal dropping ball made from this kind substrate adjuvant of the present invention, can improve Chinese medicine preparation, the particularly present not good shortcoming of dropping pill formulation taste, improve mouthfeel, more easy for patients to accept, and the drop pill that adopts the selected adjuvant of medicine of the present invention to make has shorter dissolve scattered time limit, making drug effect faster, is the medicine that cough with asthma is treated in a kind of onset faster.
4, higher safety and solve some problems in the drop pill storage process: the selected substrate of the present invention is not only additive, nutrient commonly used in the food industry, and can do medicinal, but do not see that it uses as the drug matrices adjuvant, therefore, with regard to substrate, be perfectly safe, have no side effect, a large amount of evidences, the drop pill made from this adjuvant can reduce effective ingredient separating out in storage process, the sticking ball of drop pill, easy shortcomings such as moisture absorption deliquescing, but the big production of suitability for industrialized.
Reasonable recipe of the present invention, poisonous side effect of medicine is low, and it is bigger to have overcome western medicine cough with asthma poisonous side effect of medicine, and the shortcoming that the Chinese medicine curative effect is low, flavour of a drug are many or the natural degree of substrate adjuvant is low is the medicine of the relieving cough and asthma determined of a kind of economy, material benefit, curative effect.
In order to understand the present invention better, dissolve scattered time limit, drop pill soft durometer, the drop pill with little Green Dragon drop pill glues test explanation advantages of the present invention such as ball below.
Test example 1: dissolve scattered time limit contrast experiment example
In vitro tests
The present invention be that the little Green Dragon drop pill that adjuvant is made compares with the Polyethylene Glycol, by measuring index such as dissolve scattered time limit, investigate its good releasing effect.
1. test medication: the little Green Dragon drop pill of the new substrate of the present invention (newly); With the Polyethylene Glycol is the little Green Dragon drop pill (old) that adjuvant is made.
2. method and result:
Dissolve scattered time limit: by " method is measured result such as table 1 under this item of Chinese pharmacopoeia.
The little Green Dragon drop pill (newly) that three batches in table 1 is made with the new medium adjuvant with the polyethylene glycol 6000 be little Green Dragon drop pill (old) dissolve scattered time limit made of adjuvant, weight differential relatively
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | |
| Dissolve scattered time limit (newly) (30 minutes) | ??2′1″ ????5′0″ | ??2′1″ ????5′6″ | ??2′2″ ????5′1″ | ??2′2″ ????5′4″ | ??2′5″ ????5′3″ | ??2′8″ ????5′2″ | ??2′11″ ????5′5″ | |
| 2 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ??2′1″ ????5′0″ | ??2′1″ ????5′1″ | ??2′2″ ????5′3″ | ??2′5″ ????5′4″ | ??2′5″ ????5′5″ | ??2′6″ ????5′10″ | ??2′9″ ????5′10″ | |
| 3 batches | Weight differential (± 15%) | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% | All in 10% |
| Dissolve scattered time limit (newly) (30 minutes) (old) | ??2′1″ ????5′0″ | ??2′1″ ????5′1″ | ??2′3″ ????5′3″ | ??2′2″ ????5′8″ | ??2′7″ ????5′6″ | ??2′6″ ????5′10″ | ??2′9″ ????5′10″ | |
Test data shows, the dissolve scattered time limit of the new little Green Dragon drop pill of substrate is lacking of the little Green Dragon drop pill made of adjuvant with the Polyethylene Glycol, and the ball method of double differences of the little Green Dragon drop pill that new and old substrate is made is different all to be controlled in the pharmacopeia prescribed limit.Result of the test explanation, the molten diffusing speed of the little Green Dragon drop pill made from novel adjuvant is faster, is more conducive to medicine and plays a role in the shortest time; The ball method of double differences of new substrate drop pill different to be that the little Green Dragon drop pill made of adjuvant is similar with the Polyethylene Glycol, the ball method of double differences is different all to be controlled in the pharmacopeia prescribed limit, the difference not statistically significant illustrates the alternative present chemosynthesis adjuvant of this natural substrates adjuvant, but suitability for industrialized production.
Test example 2: the present invention with the polyethylene glycol 6000 be the sticking ball comparative observation of little Green Dragon drop pill soft durometer, drop pill that adjuvant is made
Buy three batches of commercially available little Green Dragon drop pill, be loaded in the porcelain vase respectively, and use the bottle stopper good seal.Putting it into the bottom has in the exsiccator of saturated Nacl (humidity 75%) solution, exsiccator is put into 40 ℃ of drying baker of constant temperature again, and timing sampling is observed situations such as drop pill soft durometer, the sticking ball of drop pill, the results are shown in Table 2.1, table 2.2.
Three batches in table 2.1 is that the little Green Dragon drop pill reserved sample observing that adjuvant is made compares with the polyethylene glycol 6000
| 0 month | January | February | March | June | December | 18 months | ||
| 1 batch | Criterion | The result | ||||||
| Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly | |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 2 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
| 3 batches | Sticking ball | Not sticking | Not sticking | Not sticking | Not sticking | Not sticking | Sticking slightly | Sticking slightly |
| Soft durometer | Firmly | Firmly | Firmly | Firmly | Firmly | Harder | Harder | |
Table 2.2: the three batches of little Green Dragon drop pill made from the new medium adjuvant (newly) with the polyethylene glycol 6000 be little Green Dragon drop pill (old) character observation made of adjuvant relatively
| 0 month | January | February | March | June | December | 18 months | ||
| Criterion | The result | |||||||
| 1 batch | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) do not glue (newly) slightly | Sticking (old) be sticking (newly) slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 2 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) glues (newly) slightly slightly |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard (old) hard (newly) | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
| 3 batches | Sticking ball | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) | Sticking (old) do not glue (newly) slightly | Sticking (old) do not glue (newly) slightly | Sticking (old) be sticking (newly) not |
| Soft durometer | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | (old) hard (newly) firmly | Hard slightly (old) hard (newly) | Hard slightly (old) be hard (newly) slightly | |
Test data shows, the new little Green Dragon drop pill of substrate soft durometer changes and be that the little Green Dragon drop pill made of adjuvant is similar, strong slightly with the Polyethylene Glycol; The sticking ball variation of the drop pill of new substrate drop pill, firmness change and be that the little Green Dragon drop pill made of adjuvant is similar with the Polyethylene Glycol.The result of the test explanation, the sticking ball of the little Green Dragon drop pill that new and old substrate adjuvant is made changes, firmness change is similar, and the alternative present chemosynthesis adjuvant of this natural substrates adjuvant is described, but suitability for industrialized production.
The specific embodiment
Embodiment 1:
(a). get Herba Ephedrae 125g, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g, xylitol, starch are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c). with extract: the mixture of xylitol and starch: water with 1: 1.8: 0.5 ratio mixing, spray volatile oil, stir, heating in water bath, at 88～92 ℃, dropping-pill machine draught animals footpath 2.5/3.5 millimeter, to drip speed be under 10～14 droplets/minute the condition, splash in 2～6 ℃ the liquid paraffin, wiping, promptly.
Embodiment 2:
(a). get Herba Ephedrae 125g, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c). with extract: the mixture of xylitol and arabic gum: water with 1: 1.8: 0.5 ratio mixing, spray volatile oil, stir, heating in water bath, at 88～92 ℃, dropping-pill machine draught animals footpath 2.5/3.5 millimeter, to drip speed be under 10～14 droplets/minute the condition, splash in 2～6 ℃ the liquid paraffin, wiping, promptly.
Embodiment 3:
(a). get Herba Ephedrae 125g, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c). with extract: the mixture of lactose and starch: water with 1: 1.8: 0.5 ratio mixing, spray volatile oil, stir, heating in water bath, at 88～92 ℃, dropping-pill machine draught animals footpath 2.5/3.5 millimeter, to drip speed be under 10～14 droplets/minute the condition, splash in 2～6 ℃ the liquid paraffin, wiping, promptly.
Embodiment 4:
(a). get Herba Ephedrae 80g, Ramulus Cinnamomi 70g, Radix Paeoniae Alba 60g, Rhizoma Zingiberis 75g, Herba Asari 40g, Radix Glycyrrhizae 65g, Rhizoma Pinelliae 100g, five tastes 60g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 10 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 0.5: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 30 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c). with extract: the mixture of xylitol and arabic gum: water with 1: 1.8: 0.5 ratio mixing, spray volatile oil, stir, heating in water bath, at 88～92 ℃, dropping-pill machine draught animals footpath 2.5/3.5 millimeter, to drip speed be under 10～14 droplets/minute the condition, splash in 2～6 ℃ the liquid paraffin, wiping, promptly.
Embodiment 5
(a). get Herba Ephedrae 100g, Ramulus Cinnamomi 200g, Radix Paeoniae Alba 60g, Rhizoma Zingiberis 60g, Herba Asari 30g, Radix Glycyrrhizae 60g, Rhizoma Pinelliae 90g, Fructus Schisandrae Chinensis 60g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 0.4: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 20 hours filters, and decompression filtrate recycling ethanol gets thick paste;
(c). with thick paste and substrate auxiliary materials and mixing, spray volatile oil, stir, heating in water bath moves in the drop pill machine, and 80～90 ℃ drip system, splash in the methyl-silicone oil, wiping, promptly.
Embodiment 6
(a). get Herba Ephedrae 200g, Ramulus Cinnamomi 100g, Radix Paeoniae Alba 200g, Rhizoma Zingiberis 180g, Herba Asari 90g, Radix Glycyrrhizae 200g, Rhizoma Pinelliae 250g, Fructus Schisandrae Chinensis 150g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 5 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 0.6: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 18 hours filters, and decompression filtrate recycling ethanol gets thick paste;
(c). with extract: the mixture of xylitol and arabic gum: water with 1: 2.0: 0.6 ratio mixing, spray volatile oil, stir, heating in water bath, at 88～95 ℃, dropping-pill machine draught animals footpath 2.5/3.5 millimeter, to drip speed be under 10～50 droplets/minute the condition, splash in the methyl-silicone oil, wiping, promptly.
Embodiment 7
(a). get Herba Ephedrae 180g, Ramulus Cinnamomi 120g, Radix Paeoniae Alba 110g, Rhizoma Zingiberis 60g, Herba Asari 80g, Radix Glycyrrhizae 140g, Rhizoma Pinelliae 115g, Fructus Schisandrae Chinensis 105g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 3 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 0.2: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, and decompression filtrate recycling ethanol gets thick paste;
(c). with extract: the mixture of xylitol and starch: water with 1: 1.5: 0.6 ratio mixing, spray volatile oil, stir heating in water bath, be under 10～14 droplets/minute the condition in 80～100 ℃, droplets speed, splash in 2～6 ℃ the liquid paraffin, wiping, promptly.
Embodiment 8
(a). get Herba Ephedrae 110g, Ramulus Cinnamomi 110g, Radix Paeoniae Alba 110g, Rhizoma Zingiberis 110g, Herba Asari 50g, Radix Glycyrrhizae 110g, Rhizoma Pinelliae 150g, Fructus Schisandrae Chinensis 110g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 8 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 20 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c). with extract: the mixture of xylitol and arabic gum: water with 1: 1.8: 0.5 ratio mixing, spray volatile oil, stir, heating in water bath, in 88～92 ℃ of insulations splash into 0～15 ℃ liquid paraffin, wiping, promptly.
Embodiment 9
(a). get Herba Ephedrae 150g, Ramulus Cinnamomi 150g, Radix Paeoniae Alba 110g, Rhizoma Zingiberis 150g, Herba Asari 80g, Radix Glycyrrhizae 150g, Rhizoma Pinelliae 220g, Fructus Schisandrae Chinensis 150g is standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 8 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c). with extract: the mixture of xylitol and arabic gum: water with 1: 1: 0.5 ratio mixing, spray volatile oil, stir, heating in water bath, in 85～110 ℃ of insulations splash into 0～20 ℃ vegetable oil, wiping, promptly.
Embodiment 10
(a). get Herba Ephedrae 125g, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g, xylitol 416g, starch 84g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in xylitol and starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 600g drop pill, promptly.
Embodiment 11
(a). get Herba Ephedrae 125g, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g, lactose 192g, starch 58g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 7 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1.1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 18 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in lactose and starch, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10 minutes, insulation is 1.2 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
Embodiment 12
(a). get Herba Ephedrae 125g, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g, xylitol 312.5g, arabic gum 187.5g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 4 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1.2 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in xylitol and arabic gum mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 80 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.5 millimeters at 70 ℃ of temperature following system, dropper bore, splashes in 5 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
Embodiment 13
(a). get Herba Ephedrae 110g, Ramulus Cinnamomi 110g, Radix Paeoniae Alba 110g, Rhizoma Zingiberis 150g, Herba Asari 50g, Radix Glycyrrhizae 150g, Rhizoma Pinelliae 150g, Fructus Schisandrae Chinensis 150g, xylitol 285g, starch 225g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 8 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 105 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 20 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in xylitol and starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 2.6 millimeters at 60 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
Embodiment 14
(a). get Herba Ephedrae 150g, Ramulus Cinnamomi 110g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 130g, Herba Asari 75g, Radix Glycyrrhizae 100g, Rhizoma Pinelliae 200g, Fructus Schisandrae Chinensis 120g, xylitol 168g, hydroxypropyl starch 34g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 7 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1.5 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 26 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in xylitol and hydroxypropyl starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10 minutes, insulation is 1.7 millimeters at 65 ℃ of temperature following system, dropper bore, splashes in 0～10 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 10000 drop pill, promptly.
Embodiment 15
(a). get Herba Ephedrae 200g, Ramulus Cinnamomi 100g, Radix Paeoniae Alba 80g, Rhizoma Zingiberis 70g, Herba Asari 60g, Radix Glycyrrhizae 180g, Rhizoma Pinelliae 100g, Fructus Schisandrae Chinensis 110g, sorbitol 360g, starch 140g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 5～8 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1.3 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 20 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in sorbitol and starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 26 minutes, insulation is 1.1～3.5 millimeters at 68 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made the 600g drop pill, promptly.
Embodiment 16
(a). get Herba Ephedrae 200g, Ramulus Cinnamomi 60g, Radix Paeoniae Alba 60g, Rhizoma Zingiberis 60g, Herba Asari 100g, Radix Glycyrrhizae 200g, Rhizoma Pinelliae 90g, Fructus Schisandrae Chinensis 200g, lactose 350g, pectin 100g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 3 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1.4 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 12 hours filters, and decompression filtrate recycling ethanol gets thick paste;
(c): in lactose and pectin mixture, add above-mentioned extractum and volatile oil, fully mix, mixture is at 105～115 ℃ of heating and meltings, stir, mixing time is 5 minutes, insulation, at 60～67 ℃ of temperature following system, dropper bore is 1.20～2.0 millimeters, splash in 0～8 ℃ the methyl-silicone oil, make the 600g drop pill, promptly.
Embodiment 17
(a). take by weighing Herba Ephedrae 125g by proportioning raw materials, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g, starch 35g, xylitol 171g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in xylitol and starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 10000 drop pill, promptly.
Embodiment 18
(a). take by weighing Herba Ephedrae 125g by proportioning raw materials, Ramulus Cinnamomi 125g, Radix Paeoniae Alba 125g, Rhizoma Zingiberis 125g, Herba Asari 62g, Radix Glycyrrhizae 125g, Rhizoma Pinelliae 188g, Fructus Schisandrae Chinensis 125g, starch 48g, standby as sugar alcohol 158g;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in lactose and starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 60～68 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 62～66 ℃ of temperature following system, dropper bore, splashes in 0～8 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 10000 drop pill, promptly.
Embodiment 19
(a). take by weighing Herba Ephedrae 150g by proportioning raw materials, Ramulus Cinnamomi 150g, Radix Paeoniae Alba 150g, Rhizoma Zingiberis 150g, Herba Asari 80g, Radix Glycyrrhizae 150g, Rhizoma Pinelliae 220g, Fructus Schisandrae Chinensis 150g, xylitol 185g, starch 25g are standby;
(b). Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 8 times of water gagings carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 30 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c): in xylitol and starch mixture, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 30 minutes, insulation is 1.21～3.5 millimeters at 60～65 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made 10000 drop pill, promptly.
Claims (13)
1, a kind of medicine for the treatment of cough with asthma, it is characterized in that it is by 60～200 parts in Herba Ephedrae, 60～200 parts of Ramulus Cinnamomi, 60～200 parts of the Radix Paeoniae Albas, 60～200 parts of Rhizoma Zingiberiss, 30～100 parts of Herba Asaris, 60～200 parts in Radix Glycyrrhizae, 90～270 parts of the Rhizoma Pinelliaes, 60～200 parts of Fructus Schisandrae Chinensis, appropriate amount of auxiliary materials is made, wherein adjuvant comprises filler and plasticity substrate, said filler is selected from the natural adjuvant of following one or more plant origins: erythritol, sorbitol, fructose, D-ribonic acid-gamma lactone, arabitol, trehalose, D-ribose, low melting-point agarose, Lac, xylitol, Raffinose, glucose, malic acid, citric acid, isomalt, lactose, maltose etc., and they contain the water of crystallization chemical compound; Said plasticity substrate is selected from the natural adjuvant of following one or more plant origins: starch and derivant thereof, cellulose and derivant thereof, arabic gum, dextran, chitin, sesbania gum, carrageenan, Ficus elastica, Furcellaran, tragakanta, carrageenin, tamarind gum, pectin, xanthan gum, alginic acid and salt thereof, dextrin, cyclodextrin, agar, lactose; Described starch and derivant thereof such as pregelatinized Starch, modified starch, hydroxypropyl starch, carboxymethyl starch, described cellulose and derivant thereof such as methylcellulose, microcrystalline Cellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, cross-linking sodium carboxymethyl cellulose, hydroxyethylmethyl-cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose.
2, the medicine of treatment cough with asthma as claimed in claim 1, it is characterized in that it is by 110～150 parts in Herba Ephedrae, 110～150 parts of Ramulus Cinnamomi, 110～150 parts of the Radix Paeoniae Albas, 110～150 parts of Rhizoma Zingiberiss, 50～80 parts of Herba Asaris, 110～150 parts in Radix Glycyrrhizae, 150～220 parts of the Rhizoma Pinelliaes, 110～150 parts of Fructus Schisandrae Chinensis, appropriate amount of auxiliary materials is made, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: sorbitol, xylitol, lactose, maltose, and they contain the water of crystallization chemical compound; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: pregelatinized Starch, carboxymethyl starch, methylcellulose, sodium carboxymethyl cellulose, hydroxypropyl emthylcellulose, arabic gum, alginic acid, dextrin, cyclodextrin, agar, lactose.
3, the medicine of treatment cough with asthma as claimed in claim 1, it is characterized in that it is by 125 parts in Herba Ephedrae, 125 parts of Ramulus Cinnamomi, 1125 parts of the Radix Paeoniae Albas, 125 parts of Rhizoma Zingiberiss, 62 parts of Herba Asaris, 125 parts in Radix Glycyrrhizae, 1 88 parts of the Rhizoma Pinelliaes, 125 parts of Fructus Schisandrae Chinensis, appropriate amount of auxiliary materials is made, and filler adjuvant wherein is selected from following one or more the natural adjuvant of plant origin: xylitol, lactose; Plasticity substrate wherein is selected from following one or more the natural adjuvant of plant origin: starch, arabic gum.
4, as the medicine of claim 1,2 or 3 described treatment cough with asthma, it is characterized in that it can also contain chemosynthesis adjuvant and animal origin adjuvant in above-mentioned dressing, wherein filler comprises phenylglycol, hexadecanol, octadecanol, sodium stearate, tristerin, tripalmitin, carbamide, polyoxyethylene monostearate, polyoxyethylene alkyl ether; Wherein plasticity substrate comprises polyvinylpyrrolidone, crospolyvinylpyrrolidone, carbomer, polyvinyl alcohol, acrylic resin, poloxamer, gelatin.
5, the medicine of treatment cough with asthma as claimed in claim 3 is characterized in that described adjuvant is xylitol and starch, and xylitol is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
6, the medicine of treatment cough with asthma as claimed in claim 3 is characterized in that described adjuvant is lactose and starch, and lactose is 1: 0.2～1: 0.3 with the ratio of the weight of starch.
7, the medicine of treatment cough with asthma as claimed in claim 3 is characterized in that described adjuvant is xylitol and arabic gum, and the ratio of the weight of xylitol and arabic gum is 1: 0.2～1: 0.4.
8,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 1 as the medicine of claim 1,2 or 3 described treatment cough with asthma.
9,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.1～1: 0.6 as the medicine of claim 1,2 or 3 described treatment cough with asthma.
10,, it is characterized in that the adjuvant and the ratio of the weight of extract drugs extractum are 1: 0.2～1: 0.4 as the medicine of claim 1,2 or 3 described treatment cough with asthma.
11, the preparation method of claim 1,2 or 3 described treatment cough with asthma medicines is characterized in that this method comprises the steps:
(a) take by weighing 60～200 parts in Herba Ephedrae, 60～200 parts of Ramulus Cinnamomi, 60～200 parts of the Radix Paeoniae Albas, 60～200 parts of Rhizoma Zingiberiss, 30～100 parts of Herba Asaris, 60～200 parts in Radix Glycyrrhizae, 90～270 parts of the Rhizoma Pinelliaes, 60～200 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 3～10 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in crude drug 0.1～1: 0.1～1 amount, add equivalent ethanol, and after fully stirring, cold preservation 12～36 hours filters, and decompression filtrate recycling ethanol gets thick paste;
(c): in appropriate amount of auxiliary materials, add above-mentioned extractum and volatile oil, fully mix, mixture is at 45～115 ℃ of heating and meltings, stir, mixing time is 1～120 minute, insulation, at 45～95 ℃ of temperature following system, dropper bore is 1.0～4.0 millimeters, splash in-20～25 ℃ liquid paraffin, methyl-silicone oil or the vegetable oil, make drop pill, promptly.
12, the preparation method of treatment cough with asthma medicine as claimed in claim 11 is characterized in that this method comprises the steps:
(a) take by weighing 110～150 parts in Herba Ephedrae, 110～150 parts of Ramulus Cinnamomi, 110～150 parts of the Radix Paeoniae Albas, 110～150 parts of Rhizoma Zingiberiss, 50～80 parts of Herba Asaris, 110～150 parts in Radix Glycyrrhizae, 150～220 parts of the Rhizoma Pinelliaes, 110～150 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 5～8 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 20～30 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c) in appropriate amount of auxiliary materials, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 60～85 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.1～3.5 millimeters at 60～85 ℃ of temperature following system, dropper bore, splashes in 0～18 ℃ the liquid paraffin, methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
13, the preparation method of treatment cough with asthma medicine as claimed in claim 11 is characterized in that this method comprises the steps:
(a) take by weighing 125 parts in Herba Ephedrae, 125 parts of Ramulus Cinnamomi, 125 parts of the Radix Paeoniae Albas, 125 parts of Rhizoma Zingiberiss, 62 parts of Herba Asaris, 125 parts in Radix Glycyrrhizae, 188 parts of the Rhizoma Pinelliaes, 125 parts of Fructus Schisandrae Chinensis are standby;
(b) Ramulus Cinnamomi, Rhizoma Zingiberis, Herba Asari are added 6 times of water gagings and carry out vapor distillation, collect volatile oil; Medicinal residues and other medical material merge, and decocting 3 times filters, and decocting liquid is concentrated into works as relatively in 1: 1 amount of crude drug, adds equivalent ethanol, and after fully stirring, cold preservation 24 hours filters, decompression filtrate recycling ethanol, and thick paste gets extract in 70 ℃ of forced air dryings;
(c) in appropriate amount of auxiliary materials, add above-mentioned extractum and volatile oil, fully mix, mixture stirs at 64 ℃ of heating and meltings, mixing time is 10～30 minutes, insulation is 1.2～2.5 millimeters at 64 ℃ of temperature following system, dropper bore, splashes in 0 ℃ the methyl-silicone oil, liquid coolant is use up and wiped to the drop pill drop that forms, back packing to be dried is made drop pill, promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101073001A CN100421721C (en) | 2003-12-11 | 2003-12-11 | Medication for relieving cough and asthma |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101073001A CN100421721C (en) | 2003-12-11 | 2003-12-11 | Medication for relieving cough and asthma |
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| CN100421721C CN100421721C (en) | 2008-10-01 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009117952A1 (en) * | 2008-03-25 | 2009-10-01 | 深圳力瑞医药科技有限公司 | A pharmaceutical composition with effects of antitussive, antiasthma, moisturizing throat and dissipating phlegm and its preparation method |
| CN102552837A (en) * | 2010-12-27 | 2012-07-11 | 江西济民可信集团有限公司 | Preparation method of xiaoqinglong mixture |
| CN102764414A (en) * | 2011-05-05 | 2012-11-07 | 北京亚东生物制药有限公司 | Method for preparing Xiaoqinglong mixture |
| CN103463604A (en) * | 2013-09-23 | 2013-12-25 | 刘雅娟 | Drug for treating cough and asthma |
| CN104189881A (en) * | 2014-09-29 | 2014-12-10 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating asthma |
| CN105267340A (en) * | 2015-10-14 | 2016-01-27 | 天津现代职业技术学院 | Preparation method for refined ephedra decoction dropping pill |
| CN106692940A (en) * | 2017-03-23 | 2017-05-24 | 黑龙江童医生儿童生物制药有限公司 | Children sterile oral liquid preparation and preparation method thereof |
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2003
- 2003-12-11 CN CNB2003101073001A patent/CN100421721C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009117952A1 (en) * | 2008-03-25 | 2009-10-01 | 深圳力瑞医药科技有限公司 | A pharmaceutical composition with effects of antitussive, antiasthma, moisturizing throat and dissipating phlegm and its preparation method |
| CN102552837A (en) * | 2010-12-27 | 2012-07-11 | 江西济民可信集团有限公司 | Preparation method of xiaoqinglong mixture |
| CN102764414A (en) * | 2011-05-05 | 2012-11-07 | 北京亚东生物制药有限公司 | Method for preparing Xiaoqinglong mixture |
| CN102764414B (en) * | 2011-05-05 | 2014-11-26 | 北京亚东生物制药有限公司 | Method for preparing Xiaoqinglong mixture |
| CN103463604A (en) * | 2013-09-23 | 2013-12-25 | 刘雅娟 | Drug for treating cough and asthma |
| CN104189881A (en) * | 2014-09-29 | 2014-12-10 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating asthma |
| CN105267340A (en) * | 2015-10-14 | 2016-01-27 | 天津现代职业技术学院 | Preparation method for refined ephedra decoction dropping pill |
| CN105267340B (en) * | 2015-10-14 | 2019-08-09 | 天津现代职业技术学院 | A kind of preparation method refining Mahuang Tang dripping pill |
| CN106692940A (en) * | 2017-03-23 | 2017-05-24 | 黑龙江童医生儿童生物制药有限公司 | Children sterile oral liquid preparation and preparation method thereof |
| CN106692940B (en) * | 2017-03-23 | 2020-07-31 | 黑龙江童医生儿童生物制药有限公司 | A sterile oral liquid for children and its preparation method |
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| Publication number | Publication date |
|---|---|
| CN100421721C (en) | 2008-10-01 |
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Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
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| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300402 Tianjin science and Technology Park of Beichen Xinyi Road Liaohe Road No. 1 white Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081001 Termination date: 20191211 |