CN1616102A - Compound dry suspensoid agent for curing cold and its prescription and preparing method - Google Patents
Compound dry suspensoid agent for curing cold and its prescription and preparing method Download PDFInfo
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- CN1616102A CN1616102A CN 200410080500 CN200410080500A CN1616102A CN 1616102 A CN1616102 A CN 1616102A CN 200410080500 CN200410080500 CN 200410080500 CN 200410080500 A CN200410080500 A CN 200410080500A CN 1616102 A CN1616102 A CN 1616102A
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- pseudoephedrine hydrochloride
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Abstract
The compound dry suspensoid agent for treating cold contains in each bag: acetaminophen 100-250 mg, pseudoephedrine hydrochloride 15-30 mg, dextromethorphan hydrobromide 5-15 mg, Benadryl hydrochloride 5-25 mg, chlophenamine maleate 1-2 mg, and guaiamar 50-200 mg, as well as thickener and suspension assistant 1-3 % and aromatic corrective 75-95 %. The medicine of the present invention has the features of good taste, high medicine dissolving degree and high medicine bioavailability, so that it is suitable for all people, including infant, aged people and those with dysphagia.
Description
Technical field the present invention relates to compound dried suspension and the prescription and the preparation method of pharmaceutical treatment flu.
Gone on the market the at present pharmaceutical dosage form of treatment flu of background technology mostly is tablet and capsule, and the patient that tablet and capsule are not suitable for child, old people and dysphagia takes, and to the child, divided dose is not accurate enough when taking.Though the syrup listing that also has some suitable children, old people and dysphagia patien to take, but syrup exists and stores transportation inconvenience, carry trouble, repeatedly use problem such as pollution easily, and because syrup is a liquid preparation, some stability of drug are poor.
Summary of the invention the present invention is intended to overcome the tablet of treatment flu and patient that capsule is not suitable for child, old people and dysphagia takes and syrup is stored transportation inconvenience, carries trouble, repeatedly used problems such as pollution easily, medicine stability difference of having gone on the market, keep tablet, capsule and syrup characteristics separately, prepared the compound dried suspension that not only is suitable for the adult but also is particularly suitable for the treatment flu of child, old people and dysphagia patien's application.Be characterized in:
(1) stability is better.Because no matter dry suspension is being made or in storage process, all is being in dry anhydrous state all the time, and packing is tight, avoids contacting with dampness with air, thereby more stable than tablet and syrup.
(2) though dry suspension is a solid preparation, it adds mixing in water for oral taking that is has formed solution when taking, thus with syrup the same than tablet and capsule good absorbing, rapid-action, bioavailability is high.
(3) suitable crowd is wider.When dry suspension adds mixing in water for oral taking, formed like that as clear as crystal solution of similar syrup, mouthfeel is good, and patient is willing to accept, and the patient who not only is suitable for the adult but also is particularly suitable for infant, child, old people and dysphagia takes.
(4) dry suspension is a unit dose package, easy administered in divided doses, and taking dose is accurate, and can repeatedly not take easily as syrup and pollute, and the back residue medicine of recovering is easy to keeping, also can use in the future.
(5) produce, transport, preserve, carry and use more convenient.
The present invention treats in the compound dried suspension prescription of flu and contains antipyretic analgesic, vasoconstrictor, antitussive, antihistaminic and expectorant, also contains thickening agent, suspending agent and fragrant correctives.Characteristics are to adopt special prescription and preparation technology, make the medicine mouthfeel that makes good, drug dissolution and bioavailability height, and the patient who not only is suitable for the adult but also is particularly suitable for infant, child, old people and dysphagia takes.
Antipyretic analgesic, vasoconstrictor, antitussive, antihistaminic and expectorant in the compound dried suspension prescription of the invention described above treatment flu, specifically be meant acetaminophen, pseudoephedrine hydrochloride, dextromethorphan hydrobromide, diphhydramine hydrochloride, chlorphenamine maleate, guaifenesin, these medicines can be more than three kinds or three kinds applied in any combination in varing proportions.Every bag contains acetaminophen 0～300mg, best 100～250mg in the prescription, pseudoephedrine hydrochloride 5～40mg, best 15～30mg, dextromethorphan hydrobromide 0～20mg, best 5～15mg, diphhydramine hydrochloride 0～30mg, best 5～25mg, chlorphenamine maleate 0～3mg, best 1～2mg, guaifenesin 0～250mg, best 50～200mg.
Thickening agent, suspending agent in the compound dried suspension prescription of the invention described above treatment flu are specially hyprolose, hypromellose, carmethose, Polyethylene Glycol, polyvinyl alcohol, alginate, pectin, arabic gum, silica sol, xanthan gum, 30 POVIDONE K 30 BP/USP 30 etc., can be separately, also can mix use in varing proportions, total consumption be recipe quantity 0.5～4%, best 1%～3%, can the homodisperse suspendible after being added in the water to guarantee dry suspension.
Fragrant correctives in the compound dried suspension prescription of the invention described above treatment flu can be sucrose, glucose, mannitol, lactose, glycyrrhetate, steviosin, saccharin sodium, ascorbic acid, citric acid, synthetic and natural perfume material, can be separately, also can mix use in varing proportions, total consumption is 60～98%, best 75～95% of a recipe quantity, so that the dry suspension that makes is fragrant and sweet good to eat, patient takes like a shot.
Preparation the present invention treats the compound dried suspension of flu, can the medicine and the adjuvant that contain moisture is dry in advance, be ground into the above fine powder of 100 orders, then by the dilution method mix homogeneously that progressively increases step by step, for the medicine of easy oxidation also can be separately with the cellulose family enclose or make particulate, behind the total mix homogeneously of medicine, can pack packing on request, every bag of 1～2g.
The compound dried suspension that the present invention treats flu be applicable to treatment and alleviate the cough, the expectoration that cause by flu, tracheitis, bronchitis etc., pant, nasal obstruction, watery nasal discharge, shed tears, symptoms such as sneeze, heating, headache, pharyngalgia, whole body extremities aching pain.
Specific embodiment the present invention can be illustrated with prescription and the preparation method of following feature embodiment.
Embodiment 1, the pseudo-numb Lamine of U.S. breath dry suspension:
Prescription: acetaminophen 162.5g
Pseudoephedrine hydrochloride 15g
Diphhydramine hydrochloride 12.5g
Dextromethorphan hydrobromide 7.5g
Xanthan gum 20g
Hyprolose 24g
Glycyrrhizic acid 8.5g
Spice 30g
Cane sugar powder 1720g
Make 1000 bags
Preparation method: all supplementary materials are dried to moisture below 1% except that spice, are ground into 100 order fine powders.Take by weighing in the prescription each supplementary material fine powder by the dilution method mix homogeneously that progressively increases step by step, packing promptly.
Embodiment 2, phenol guaifenesin, pseudoephedrine hydrochloride and dextromethorphan hydrobromide dry suspension:
Prescription: acetaminophen 250g
Pseudoephedrine hydrochloride 30g
Dextromethorphan hydrobromide 15g
Guaifenesin 100g
Xanthan gum 16g
Hyprolose 10g
Hypromellose 20g
Steviosin 5g
Spice 30g
Cane sugar powder 1524g
Make 1000 bags
Preparation method is with embodiment 1.
Embodiment 3, the guaifenesin, pseudoephedrine hydrochloride and dextromethorphan hydrobromide dry suspension:
Prescription: guaifenesin 100g
Pseudoephedrine hydrochloride 30g
Dextromethorphan hydrobromide 15g
Carmethose 7.5g
Xanthan gum 7.5g
Silica sol 12g
Saccharin sodium 1.5g
Spice 15g
Cane sugar powder 1311.5g
Make 1000 bags
Preparation method is with embodiment 1.
Embodiment 4, the paracetamol pseudoephedrine hydrochloride and cholrphenamine maleate dry suspension:
Prescription: acetaminophen 250g
Pseudoephedrine hydrochloride 15g
Chlorphenamine maleate 1g
Xanthan gum 15g
Hypromellose 18g
Glycyrrhizic acid 6g
Spice 15g
Cane sugar powder 1180g
Make 1000 bags
Preparation method is with embodiment 1.
Embodiment 5, the pseudoephedrine hydrochloride dry suspension:
Prescription: pseudoephedrine hydrochloride 30g
Dextromethorphan hydrobromide 10g
Chlorphenamine maleate 2g
Xanthan gum 12g
Hypromellose 6g
Steviosin 6g
Spice 18g
Cane sugar powder 916g
Make 1000 bags
Preparation method is with embodiment 1.
Embodiment 6, the acetaminophen compound dry suspension:
Prescription: acetaminophen 162.5g
Pseudoephedrine hydrochloride 15g
Chlorphenamine maleate 1g
Dextromethorphan hydrobromide 7.5g
Xanthan gum 12g
Hypromellose 15g
Glycyrrhizic acid 9g
Spice 30g
Cane sugar powder 1248g
Make 1000 bags
Preparation method is with embodiment 1.
Above feature embodiment 1 to feature embodiment 6, for the medicine example hydrochloric acid pseudoephedrine of easy oxidation also can be separately with the cellulose family enclose or make particulate, and then with other medicines and adjuvant powder mix homogeneously, pack packing on request gets final product.
The product that makes by above-mentioned prescription and preparation method meets the prescription of Chinese Pharmacopoeia to dry suspension.
Claims (6)
- Compound dried suspension and the prescription and the preparation method of 1, treatment flu.Contain antipyretic analgesic, vasoconstrictor, antitussive, antihistaminic and expectorant in this dry suspension prescription, also contain thickening agent, suspending agent and fragrant correctives.Characteristics are to adopt special prescription and preparation technology, make the medicine mouthfeel that makes good, drug dissolution and bioavailability height, and the patient who not only is suitable for the adult but also is particularly suitable for infant, child, old people and dysphagia takes.
- 2, the dosage form of the compound dried suspension of the described treatment flu of claim 1, prescription and preparation method thereof, feature embodiment 1 prescription and the preparation method that cease pseudo-numb Lamine dry suspension, phenol guaifenesin, pseudoephedrine hydrochloride and dextromethorphan hydrobromide dry suspension, guaifenesin, pseudoephedrine hydrochloride and dextromethorphan hydrobromide dry suspension, paracetamol pseudoephedrine hydrochloride and cholrphenamine maleate dry suspension, pseudoephedrine hydrochloride dry suspension and acetaminophen compound dry suspension to feature embodiment 6 cited representative U.S.As particularly, but the present invention is not limited to the prescription among 6 cited embodiment.
- 3, antipyretic analgesic, vasoconstrictor, antitussive, antihistaminic and the expectorant in the compound dried suspension prescription of the described treatment flu of claim 1 and claim 2, specifically be meant acetaminophen, pseudoephedrine hydrochloride, dextromethorphan hydrobromide, diphhydramine hydrochloride, chlorphenamine maleate, guaifenesin, these medicines can be more than three kinds or three kinds applied in any combination in varing proportions.Every bag contains acetaminophen 0～300mg, best 100～250mg in the prescription, pseudoephedrine hydrochloride 5～40mg, best 15～30mg, dextromethorphan hydrobromide 0～20mg, best 5～15mg, diphhydramine hydrochloride 0～30mg, best 5～25mg, chlorphenamine maleate 0～3mg, best 1～2mg, guaifenesin 0～250mg, best 50～200mg.
- 4, thickening agent, the suspending agent in the compound dried suspension prescription of the described treatment flu of claim 1 and claim 2 is specially hyprolose, hypromellose, carmethose, Polyethylene Glycol, polyvinyl alcohol, alginate, pectin, arabic gum, silica sol, xanthan gum, 30 POVIDONE K 30 BP/USP 30 etc., can be separately, also can mix use in varing proportions, total consumption be recipe quantity 0.5～4%, best 1%～3%, can the homodisperse suspendible after being added in the water to guarantee dry suspension.
- 5, the fragrant correctives in the compound dried suspension prescription of the described treatment flu of claim 1 and claim 2 can be sucrose, glucose, mannitol, lactose, glycyrrhetate, steviosin, saccharin sodium, ascorbic acid, citric acid, synthetic and natural perfume material, can be separately, also can mix use in varing proportions, total consumption is 60～98%, best 75～95% of a recipe quantity, so that the dry suspension that makes is fragrant and sweet good to eat, patient takes like a shot.
- 6, the special prescription of the compound dried suspension of the described treatment flu of claim 1 and claim 2 and preparation technology are broken into medicine and ingredient powder fine powder and adopt the abundant mix homogeneously of dilution method that progressively increases step by step, for the medicine example hydrochloric acid pseudoephedrine of easy oxidation also can be separately with the cellulose family enclose or make particulate, and then with other medicines and adjuvant powder mix homogeneously, pack packing gets final product on request.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN 200410080500 CN1616102A (en) | 2004-10-12 | 2004-10-12 | Compound dry suspensoid agent for curing cold and its prescription and preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410080500 CN1616102A (en) | 2004-10-12 | 2004-10-12 | Compound dry suspensoid agent for curing cold and its prescription and preparing method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493503C (en) * | 2006-10-24 | 2009-06-03 | 浙江康德药业集团有限公司 | Taste masked dry suspension for treating infant cold and method for preparing same |
| CN102657616A (en) * | 2012-04-30 | 2012-09-12 | 青岛国海生物制药有限公司 | Paracetamol dry suspension for treating common cold in children |
| CN103127113A (en) * | 2013-02-19 | 2013-06-05 | 青岛正大海尔制药有限公司 | Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof |
| US10610559B2 (en) * | 2016-06-27 | 2020-04-07 | Uwais M. Syed | Combined herbal and pharmaceutical composition and method |
-
2004
- 2004-10-12 CN CN 200410080500 patent/CN1616102A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493503C (en) * | 2006-10-24 | 2009-06-03 | 浙江康德药业集团有限公司 | Taste masked dry suspension for treating infant cold and method for preparing same |
| CN102657616A (en) * | 2012-04-30 | 2012-09-12 | 青岛国海生物制药有限公司 | Paracetamol dry suspension for treating common cold in children |
| CN103127113A (en) * | 2013-02-19 | 2013-06-05 | 青岛正大海尔制药有限公司 | Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof |
| CN103127113B (en) * | 2013-02-19 | 2014-07-30 | 青岛正大海尔制药有限公司 | Compound pseudoe-phedrine hydro-chloride dry suspension and preparation method thereof |
| US10610559B2 (en) * | 2016-06-27 | 2020-04-07 | Uwais M. Syed | Combined herbal and pharmaceutical composition and method |
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