CN1586528A - Method for nano plant Chinese medicine - Google Patents
Method for nano plant Chinese medicine Download PDFInfo
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- CN1586528A CN1586528A CN 200410060720 CN200410060720A CN1586528A CN 1586528 A CN1586528 A CN 1586528A CN 200410060720 CN200410060720 CN 200410060720 CN 200410060720 A CN200410060720 A CN 200410060720A CN 1586528 A CN1586528 A CN 1586528A
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Abstract
The present invention provides nanometerizing plant Chinese medicinal materials. Single or compound Chinese medicinal material is crushed in a closed high speed centrifugal shearing and smashing machine at normal temperature to form solid particle of 50-200 nm average size. During the crushing, the main shaft rotating at high speed provides powerful centrifugal force and high frequency shearing force in the ceramic crushing rings symmetrically distributed in the subsidiary shaft, and through cutting and crushing material grains in short time, the plant cell wall is broken and the effective components are released directly to improve the medicine leaching rate and raise the medicine bioavailability. The operation may be continuous, semi-continuous or intermittent and may be a dry or wet process. The present invention has no pollution, no loss in effective components, short time and simple operation.
Description
Technical field
The present invention relates to a kind of method with the botanical herbs nanorize.
Background technology
Chinese medicine is with a long history, has the advantage that drug effect is peculiar, side effect is little, but because to decoct trouble, flavour of a drug hardship, dosage big, and is difficultly accepted by the patient.The Effective Components of Chinese Herb majority is present in the Cell sap, and the release of effective ingredient need be passed through diffusion, the osmosis of cell wall, cell membrane, and existing Chinese medicine breaking method is difficult to cell broken fully, fully effective component extracting.By the Chinese patent medicine of former medicine preparation also all the ubiquity dissolution rate reduce, the shortcoming of drug effect difference.Effective Components of Chinese Herb often uses organic reagent to extract, and not only extraction ratio is low, causes the particularly waste of valuable ingredient of Chinese medicine of raw material, and can't avoid pollution problems.
Nanotechnology at present also brings life for the modernization of Chinese medicine in the development of medicine, biological field, if botanical herbs is crushed to nano level granule, make plant cell wall broken fully, directly stripping of the content in the breaking cellular wall cell is easily directly absorbed by human body.In addition, its specific surface area increases greatly, increase with the medicine-feeding part contact area, and its adhesion property makes medicine prolong at the absorption site adsorption time, therefore can effectively improve ingredient absorption in vivo speed and degree of absorption, thereby increase its bioavailability.
The objective of the invention is to shear ultrafine crusher with the botanical herbs nanorize, significantly improve the dissolution and the bioavailability of medicine, to overcome the deficiencies in the prior art with the totally enclosed type high speed centrifugation.
The totally enclosed type high speed centrifugation is sheared ultrafine crusher (pulverization principle of ultrafine crusher such as accompanying drawing 2) and is adopted advanced superfine technique, the a plurality of potteries that are symmetrically distributed on powerful centrifugal force that obtains by the main shaft high speed rotating and the countershaft are pulverized the altofrequency shearing force of ring, at short notice to raw material particle cutting, roll, it is ground into homogenizing superfines in the nanometer range.This instrument pulverization cylinder chuck can feed cooling water, makes crushing process near carrying out under the room temperature, has guaranteed that medicine active component in crushing process is not destroyed.Pulverizing ring that contacts with medicine and pulverization cylinder inwall all are ceramic material, are easy to clean and sterilization; Pulverization cylinder adopts double mechanical seal, and the medicine superfine grinding is finished under nonpollution environment.In addition, can select dry method or wet method with the botanical herbs nano-pulverization according to the requirement of pharmaceutical preparation.If the requirement of medication preparation or the situation that needs the tracing observation medicine to pulverize can be selected semicontinuous or intermittently operated, in time adjust the disintegrating process parameter.
Because plant cell wall, cell membrane are broken fully after the superfine grinding, effective ingredient can directly contact with solvent, has therefore reduced loss of active ingredients.It is good to pulverize back medicine homogeneity, can be prepared into various dosage forms as requested.For example make granule or capsule, directly make tablet or pill (watered pill or honeyed pill) etc.
A series of nanometer formulation medicines of Yang Mengjun invention are the prepared slices of Chinese crude drugs that adopt microwave extracting, concentrating under reduced pressure, the preparation of supersonic jet technology.Temperature is between 30 ℃-60 ℃.The present invention's difference with it is that preparation process carries out in room temperature, free of contamination hermetic container, the method that adopts mechanical force is directly with the plant medicine miniaturization, and the pulverizing time is short, and is that full powder is used as medicine, no loss of active ingredients.
Also have in addition by jet mill Chinese crude drug is carried out the report that micronizing is handled, for example the high velocity air that utilizes of Li Jianli invention is pulverized the method for preparing the ultra micro Chinese herbal medicine powder, comprise operations such as air compression, air storage, pulverizing, minimum grain diameter is at 0.5-10 μ m.And operation of the present invention is simple, and directly pulverize the back that feeds intake, and the mean diameter of the final microgranule that obtains is 50-200nm.
After Chinese medicine is crushed to Nano grade, medicine dissolution in vitro and the absorption property in gastrointestinal will be better than the medicine of traditional method preparation.
Consult through document and patent widely, still find no by superfine grinding method and be prepared into the relevant report of particle diameter at the nanometer botanical herbs of 50-200nm.
Summary of the invention
The present invention prepares nanometer botanical herbs powder body by totally enclosed type high speed centrifugation shearing ultrafine crusher dry method and wet method.The a plurality of potteries that are symmetrically distributed on powerful centrifugal force that obtains by the main shaft high speed rotating in the crushing process and the countershaft are pulverized the altofrequency shearing force of ring, at short notice the raw material particle is cut, rolls, make the cell wall of plant cell be broken, effective ingredient directly discharges, thereby effectively improve the dissolution rate of medicine, significantly improve bioavailability of medicament.
Details are as follows to technological process of the present invention (referring to Fig. 1) specific implementation process below:
(1) dry process nanometer botanical herbs powder.
The monotaste plant medicine is according to " the kind selection that Chinese pharmacopoeia is recorded, the compound plant medicine is according to " the former medicine of Chinese pharmacopoeia regulation proportioning.After the medical material cold drying, routine is ground into fine powder, makes each uniform component distribution in the fine powder.Fine powder is put into the totally enclosed type high speed centrifugation that has chuck to be sheared in the pulverization cylinder of ultrafine crusher, rise airtight with knob control pulverization cylinder with main shaft, string has a plurality of potteries to pulverize ring on six countershafts around the main shaft owing to be symmetrically distributed in, and fine powder just enters pottery and pulverizes in the slit of ring.The pulverization cylinder chuck feeds cooling water makes operating temperature be controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is controlled at the 800-2400rpm scope, and the pulverizing time is controlled at 30-90 minute scope.Powerful centrifugal force that the main shaft high speed rotating obtains during pulverizing and pottery are pulverized the altofrequency shearing force of ring, at short notice to the cutting of raw material particle, roll, it is ground into homogenizing superfines in the nanometer range.
(2) wet method prepares nanometer botanical herbs powder.
In the rough machined botanical herbs fine powder of process, add distilled water and make dispersant, the weight ratio of Chinese medicine fine powder and distilled water is 1: 20～30, after being uniformly dispersed, soaked 1～24 hour, transfer to then in the pulverization cylinder of the ultrafine crusher that has chuck, it is airtight with main shaft to rise with knob control pulverization cylinder, and the peptizaiton of dispersant makes fine powder be distributed in pottery and pulverizes in the slit of ring.Feeding cooling water makes operating temperature be controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is controlled at the 800-2400rpm scope, and the pulverizing time is controlled at 30-90 minute scope.
Carry out the mensuration of granularity and particle size distribution through ZetaPALS light scattering particle size distribution instrument, the Chinese medicinal powder particle diameter of dry method and wet method preparation is at 50-200nm, and particle size distribution is even.
According to the requirement of pharmaceutical preparation, can select continuous, semicontinuous or intermittently operated.
The Nano Chinese medicine powder body of the present invention's preparation is compared with the medicine of traditional method preparation, and dissolution in vitro and bioavailability improve, and pollution-free, no loss of active ingredients, and the time is short, easy and simple to handle, has great Pharmaceutical using value.
Description of drawings
Fig. 1: preparation technology's flow chart of Nano Chinese medicine powder body.
Fig. 2: the pulverization principle figure of ultrafine crusher.
Fig. 3: the particle size distribution figure of nanometer six drugs containing rehmanniae powder body.
Fig. 4: the optical microphotograph feature photo of nanometer six drugs containing rehmanniae powder body.
Fig. 5: the optical microphotograph feature photo of nanometer Radix Notoginseng powder body.
Fig. 6: the particle size distribution figure of nanometer Rhizoma Chuanxiong powder body.
Specific embodiments
Introduce specific embodiments of the present invention in detail below in conjunction with accompanying drawing.
Embodiment 1: wet method prepares nanometer six drugs containing rehmanniae powder.The former medicine of regulation proportioning six drugs containing rehmanniae according to Chinese Pharmacopoeia: Radix Rehmanniae Preparata 160g, Fructus Corni 80g, Rhizoma Dioscoreae 80g, Poria 60g, Cortex Moutan 60g, Rhizoma Alismatis 60g, after the cold drying, routine is ground into fine powder, makes each uniform component distribution in the fine powder.
In the six drugs containing rehmanniae fine powder, add distilled water and make dispersant, the weight ratio of Chinese medicine fine powder and distilled water is 1: 20, after being uniformly dispersed, soaked 24 hours, transfer to the totally enclosed type high speed centrifugation again and shear in the pulverization cylinder of ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and the peptizaiton of distilled water makes raw material powder be distributed in pottery and pulverizes in the slit of ring.The pulverization cylinder chuck inserts cooling water makes operating temperature be controlled at room temperature.Pulverization cylinder is carried out continuous pulverizing after airtight, and the speed of mainshaft is 1500rpm, and the pulverizing time is 60 minutes.The particle diameter of powder is determined as 161.9nm through ZetaPALS light scattering particle size distribution instrument after the superfine grinding, and particle size distribution as shown in Figure 3.Can see narrower particle size distribution, illustrate by the totally enclosed type high speed centrifugation and shear the six drugs containing rehmanniae nanometer powder that ultrafine crusher can obtain even particle distribution.The optical microphotograph feature of nanometer six drugs containing rehmanniae powder can't be seen the feature of crude drug as shown in Figure 4 behind the six drugs containing rehmanniae nanorize, cell membrane and cell wall are broken fully, so directly stripping of effective ingredient.
Gained solution behind the six drugs containing rehmanniae nano-pulverization can be directly as drink liquid; The separating out of starch and polysaccharide increases six drugs containing rehmanniae viscosity, can directly make pill after concentrating and need not add adjuvant.
Get nanometer six drugs containing rehmanniae powder and six drugs containing rehmanniae fine powder and be the contrast experiment of dissolution in vitro.According to " the second method agar diffusion method in two dissolution determination methods of Chinese pharmacopoeia version in 2000, utilize dissolution test system, with the paeonol is the stripping index, is release medium with the simulated gastric fluid, puts medicated powder 2.000g in every glass, stir with 100 rev/mins stirring paddles, sampling in per 9 minutes is once used the chloroform extraction paeonol, the amount of the paeonol of parallel assay different time fine powder and nano powder stripping, each surveys five parts.Carry out statistical analysis with t-check, P＜0.05 o'clock has significant difference.Table 1, table 2 are respectively the measurement result of the dissolution in vitro of six drugs containing rehmanniae fine powder and nanometer powder.
Table 1: the dissolution of six drugs containing rehmanniae fine powder (mg/2g)
| The 12345 meansigma methods time of sequence number (min) |
| ???????0.01697???0.02544???0.04917???0.02071???0.03171???0.028907??9 ???????0.02003???0.06777???0.03645???0.06253???0.04849???0.047056??18 ???????0.05753???0.09281???0.05753???0.04405???0.05492???0.061369??27 ???????0.07261???0.0804????0.07048???0.04608???0.05419???0.064753??36 ???????0.06922???0.08754???0.07478???0.09436???0.05659???0.076499??45 |
Annotate: dissolution is linear in time, and the dissolution of each time point has significant difference (P=0.004612)
Table 2: the dissolution (mg/2g) of nanometer six drugs containing rehmanniae powder
| Sequence number 12345 meansigma methodss |
| 0.1002451 0.0681837 0.1084982 0.0915309 0.0715428 0.0880001 0.0853484 0.097533 0.0853484 0.0915309 0.0890173 0.0897556 0.1151863 0.1114894 0.1093873 0.1082034 0.0983398 0.1085212 0.0788021 0.0925522 0.1090902 0.0711174 0.0745659 0.0852256 0.1177196 0.088274 0.1084982 0.084868 0.0860727 0.0970865 mean values 0.0994603 0.0916065 0.1041645 0.0905957 0.0833661 0.0937178 |
Annotate: dissolution is non-linear relation in time, the dissolution there was no significant difference (P=0.06471) of each time point
The dissolution in vitro description of test: the stripping of the index components paeonol of fine powder need be passed through diffusion, the osmosis of cell membrane, cell wall, and therefore, its dissolution and time are linear.And the cell wall of nanometer powder, cell membrane are broken fully, so the stripping in a large number of paeonol within a short period of time, do not have linear relationship with the time.After 45 minutes, the accumulation dissolution of nanometer powder will be higher than the accumulation dissolution of fine powder, illustrates that nano-pulverization can significantly improve the dissolution of six drugs containing rehmanniae.
Embodiment 2: wet method prepares nanometer six drugs containing rehmanniae powder.In the six drugs containing rehmanniae fine powder, add distilled water and make dispersant, the weight ratio of Chinese medicine fine powder and distilled water is 1: 25, after being uniformly dispersed, soaked 12 hours, transfer to the totally enclosed type high speed centrifugation again and shear in the pulverization cylinder of ultrafine crusher, the pulverization cylinder chuck inserts cooling water makes operating temperature be controlled at room temperature.Pulverization cylinder is carried out continuous pulverizing after airtight, and the speed of mainshaft is 800rpm, and the pulverizing time is 90 minutes.The particle diameter of powder is determined as 200nm through ZetaPALS light scattering particle size distribution instrument after the superfine grinding.
Embodiment 3: wet method prepares nanometer six drugs containing rehmanniae powder.In the six drugs containing rehmanniae fine powder, add distilled water and make dispersant, the weight ratio of Chinese medicine fine powder and distilled water is 1: 30, after being uniformly dispersed, soaked 1 hour, transfer to the totally enclosed type high speed centrifugation again and shear in the pulverization cylinder of ultrafine crusher, the pulverization cylinder chuck inserts cooling water makes operating temperature be controlled at room temperature.Pulverization cylinder is carried out continuous pulverizing after airtight, and the speed of mainshaft is 2400rpm, and the pulverizing time is 30 minutes.The particle diameter of powder is determined as 134nm through ZetaPALS light scattering particle size distribution instrument after the superfine grinding.
Embodiment 4: wet method prepares the nanometer Notoginseng Root: in the Radix Notoginseng fine powder, add distilled water and make dispersant, the weight ratio of Radix Notoginseng fine powder and distilled water is 1: 30, after being uniformly dispersed, soaked 24 hours, transfer to the totally enclosed type high speed centrifugation again and shear in the pulverization cylinder of ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and fine powder just enters into the slit that pottery is pulverized ring.The pulverization cylinder chuck inserts cooling water makes operating temperature be controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is 800rpm, and the pulverizing time is 90 minutes.The particle diameter of powder is determined as 168.1nm through ZetaPALS light scattering particle size distribution instrument after the superfine grinding.The optical microphotograph feature of nanometer Radix Notoginseng powder body can be seen the feature of no former plant tissue behind the Radix Notoginseng nanorize as shown in Figure 5, and cell wall and cell membrane are broken fully, directly stripping of effective ingredient.
The broken back of Radix Notoginseng nanopowder gained solution can be made pill after perhaps concentrating directly as drink liquid.
Group dosage (g/Kg) number of animals (only) bleeding stopping period (min)
Normal saline group/5 10.94 ± 3.1
Fine powder group 0.7 5 6.68 ± 0.78
*
Nano powder group 0.7 5 4.51 ± 1.64
*
Radix Notoginseng has anastalsis, gets Radix Notoginseng nanopowder and Radix Notoginseng fine powder and does Radix Notoginseng to the hemorrhage influence experiment of mice docking.Get 20 of kunming mices, male and female half and half are divided into 4 groups at random, respectively gastric infusion, once a day, successive administration 4 days, 1h after the last administration blocks mouse tail point 0.3cm place in order to cutting, treat that blood automatic one goes out to pick up counting, inhale to dehematize with filter paper every 30s and drip once, till blood stops (depletion of blood when filter paper is inhaled) naturally, the record bleeding time.Each administration group and normal saline group are relatively carried out the t check, the results are shown in Table 3.
Table 3: Radix Notoginseng is irritated stomach to the mice influence in docking bleeding time (n=5, x ± min)
Annotate: compare with the normal saline group
*P＜0.05, nano powder group and former powder group be P＜0.05 relatively.
By table 3 as seen: compare with the normal saline group (1), and fine powder and nano powder all can obviously reduce the bleeding time (P＜0.05) of mice, show that the two all has the hemostatic effect.(2) nano powder group and fine powder group comparison bleeding stopping period have significant difference (P＜0.05), show that the anastalsis of Radix Notoginseng nanopowder obviously is better than the Radix Notoginseng fine powder.After being the Radix Notoginseng nanometer, drug effect is improved.
Embodiment 5: wet method prepares the nanometer Notoginseng Root: in the Radix Notoginseng fine powder, add distilled water and make dispersant, the weight ratio of Radix Notoginseng fine powder and distilled water is 1: 20, after being uniformly dispersed, soaked 6 hours, transfer to the totally enclosed type high speed centrifugation again and shear in the pulverization cylinder of ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and fine powder just enters into the slit that pottery is pulverized ring.The pulverization cylinder chuck inserts cooling water makes operating temperature be controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is 1200rpm, and the pulverizing time is 60 minutes.The particle diameter of powder is determined as 153.8nm through ZetaPALS light scattering particle size distribution instrument after the superfine grinding.
Embodiment 6: dry process nanometer Notoginseng Root: the Radix Notoginseng fine powder is put into the totally enclosed type high speed centrifugation shear in the pulverization cylinder of ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and fine powder just enters into the slit that pottery is pulverized ring.The pulverization cylinder chuck inserts cooling water makes operating temperature be controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is 2400 scopes, and the pulverizing time is 30 minutes.The particle diameter of powder is determined as 142.5nm through ZetaPALS light scattering particle size distribution instrument after the superfine grinding.
Embodiment 7: dry process nanometer Szechwan Lovage Rhizome: after the Rhizoma Chuanxiong rhizome is cleaned oven dry, routine is ground into fine powder, put into the totally enclosed type high speed centrifugation and shear in the ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and fine powder just enters into the slit that pottery is pulverized ring.Operating temperature is controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is 2400rpm, and the pulverizing time is 30 minutes.The mean diameter of powder is 50nm after the Rhizoma Chuanxiong superfine grinding.The particle size distribution of nanometer Szechwan Lovage Rhizome as shown in Figure 6.Can see narrower particle size distribution, illustrate by the totally enclosed type high speed centrifugation and shear the Rhizoma Chuanxiong nanometer powder end that ultrafine crusher can obtain even particle distribution.
With the ferulic acid is the stripping index, adds the artificial gastric acid of 300mL (pH=2.1) in Rhizoma Chuanxiong nanometer powder and fine powder, and constant temperature (37 ℃) is crossed the leaching clear liquid again through filtering with microporous membrane with it after stirring 30min; Difference by ferulic acid stripping quantity in the Rhizoma Chuanxiong before and after the high-performance liquid chromatogram determination nano-pulverization.Result such as following table:
Table 4: the external stripping quantity of ferulic acid in the Rhizoma Chuanxiong
Sample stripping quantity (mg/3g)
Rhizoma Chuanxiong nanometer powder 0.37701
Rhizoma Chuanxiong fine powder 0.27647
By table 4 as seen, the more former Rhizoma Chuanxiong fine powder of the Rhizoma Chuanxiong nanometer powder broken back external stripping quantity of ferulic acid has improved 36.4%, so nanotechnology can promote the stripping of effective ingredient in the Chinese medicine.
Can be directly after Rhizoma Chuanxiong nanometer powder is broken as powder, make capsule or be pressed into tablet.
Embodiment 8: dry process nanometer Szechwan Lovage Rhizome: after the Rhizoma Chuanxiong rhizome is cleaned oven dry, routine is ground into fine powder, put into the totally enclosed type high speed centrifugation and shear in the ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and fine powder just enters into the slit that pottery is pulverized ring.Operating temperature is controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is 1700rpm, and the pulverizing time is 60 minutes.The mean diameter of powder is 60.3nm after the Rhizoma Chuanxiong superfine grinding.
Embodiment 9: dry process nanometer Szechwan Lovage Rhizome: after the Rhizoma Chuanxiong rhizome is cleaned oven dry, routine is ground into fine powder, put into the totally enclosed type high speed centrifugation and shear in the ultrafine crusher, it is airtight with main shaft to rise with knob control pulverization cylinder, and fine powder just enters into the slit that pottery is pulverized ring.Operating temperature is controlled at room temperature.Crusher cavity is carried out continuous pulverizing after airtight, and the speed of mainshaft is 800rpm, and the pulverizing time is 90 minutes.The mean diameter of powder is 83.6nm after the Rhizoma Chuanxiong superfine grinding.
Claims (3)
1, a kind of method of botanical herbs nanorize is characterized in that being divided into two kinds of dry process method and wet preparation methods:
1. dry process: after the medical material cold drying, routine is ground into 80-200 order fine powder, then fine powder being put into the totally enclosed type high speed centrifugation that has chuck shears in the pulverization cylinder of ultrafine crusher and carries out continuous pulverizing, operating temperature is controlled at room temperature, the speed of mainshaft is 800-2400rpm, the pulverizing time is 30-90 minute, and being ground into particle diameter is 50-200nm homogenizing superfines;
2. wet method preparation: in the rough machined botanical herbs fine powder of process, add distilled water and make dispersant, the weight ratio of Chinese medicine fine powder and distilled water is 1: 20～30, after being uniformly dispersed, soaked 1～24 hour, then fine powder is put into the totally enclosed type high speed centrifugation that has chuck and sheared in the pulverization cylinder of ultrafine crusher and carry out continuous pulverizing, operating temperature is controlled at room temperature, the speed of mainshaft is 800-2400rpm, and the pulverizing time is 30-90 minute, and being ground into particle diameter is 50-200nm homogenizing superfines.
2, according to the method for the described botanical herbs nanorize of claim 1, it is characterized in that crushing process carries out under air-proof condition, the medicine superfine grinding is finished under nonpollution environment.
3,, it is characterized in that to select continuous, semicontinuous or intermittently operated according to the method for the described botanical herbs nanorize of claim 1.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102578382A (en) * | 2012-03-29 | 2012-07-18 | 常熟市润丰农业有限公司 | Preparation method for duck feed traditional Chinese medicine healthcare licking brick |
| CN102763840A (en) * | 2011-05-05 | 2012-11-07 | 吕胜一 | Infinite expansion method of food field and manufacturing equipment |
| CN103006717A (en) * | 2012-12-05 | 2013-04-03 | 深圳市岩代投资有限公司 | Method for extracting ingredients with lucid ganoderma effects |
| CN104611180A (en) * | 2015-02-13 | 2015-05-13 | 南通蛇类治疗研究所 | Nanoemulsion health wine made of selenium-enriched plants |
| CN105030847A (en) * | 2015-06-23 | 2015-11-11 | 上海善力健生物科技有限公司 | Preparation method of nanometer Chinese herbal medicine ultrafine powder |
| CN110960602A (en) * | 2019-12-20 | 2020-04-07 | 上海健康医学院 | Method for extracting and nanocrystallizing insoluble components in plant |
| CN113876877A (en) * | 2021-11-04 | 2022-01-04 | 纳元(宁波)生物医药科技有限公司 | Micro traditional Chinese medicine tablet and preparation method thereof |
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2004
- 2004-08-13 CN CN 200410060720 patent/CN1586528A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102763840A (en) * | 2011-05-05 | 2012-11-07 | 吕胜一 | Infinite expansion method of food field and manufacturing equipment |
| CN102578382A (en) * | 2012-03-29 | 2012-07-18 | 常熟市润丰农业有限公司 | Preparation method for duck feed traditional Chinese medicine healthcare licking brick |
| CN102578382B (en) * | 2012-03-29 | 2013-12-11 | 常熟市润丰农业有限公司 | Duck feed additive |
| CN103006717A (en) * | 2012-12-05 | 2013-04-03 | 深圳市岩代投资有限公司 | Method for extracting ingredients with lucid ganoderma effects |
| CN103006717B (en) * | 2012-12-05 | 2014-04-30 | 深圳市岩代投资有限公司 | Method for extracting ingredients with lucid ganoderma effects |
| CN104611180A (en) * | 2015-02-13 | 2015-05-13 | 南通蛇类治疗研究所 | Nanoemulsion health wine made of selenium-enriched plants |
| CN105030847A (en) * | 2015-06-23 | 2015-11-11 | 上海善力健生物科技有限公司 | Preparation method of nanometer Chinese herbal medicine ultrafine powder |
| CN110960602A (en) * | 2019-12-20 | 2020-04-07 | 上海健康医学院 | Method for extracting and nanocrystallizing insoluble components in plant |
| CN113876877A (en) * | 2021-11-04 | 2022-01-04 | 纳元(宁波)生物医药科技有限公司 | Micro traditional Chinese medicine tablet and preparation method thereof |
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