CN1362246A - Nano Bupleuric medicine for regulating Shaoyang and it spreparation - Google Patents
Nano Bupleuric medicine for regulating Shaoyang and it spreparation Download PDFInfo
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- CN1362246A CN1362246A CN 01100748 CN01100748A CN1362246A CN 1362246 A CN1362246 A CN 1362246A CN 01100748 CN01100748 CN 01100748 CN 01100748 A CN01100748 A CN 01100748A CN 1362246 A CN1362246 A CN 1362246A
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Abstract
The present invention discloses a nano minor-buplerum preparation medicine. It is made up by using 7 Chinese medicinal materials of nano bupleurum, nano ginger pineline, nano scutellaria, nano codonopsis, nano licorice and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of heat radiation of inducing sweat, the little bupleurum preparation medicine of the nanometer of dispersing the stagnated liver-QI for regulating the stomach the invention still further relates to the method for this medication preparation.
Herba Sidae Rhombifoliae granule is a kind of traditional Chinese patent medicine, mainly contain protect the liver, function of gallbladder promoting, analgesic, antiinflammatory, antipathogen is regulated the human body function of exempting from service, and promotes hypophysis cerebri-adrenal cortex function, anticoagulant and influence effect such as isolated smooth muscle, be used for Shaoyang disease, but traditional Herba Sidae Rhombifoliae granule disintegrate is slower, absorbs not exclusively, bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the little bupleurum preparation medicine of the nanometer of increase evident in efficacy.
Another object of the present invention provides the preparation method of the little bupleurum preparation medicine of this nanometer.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano bupleurum 220-260 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 70-110 part nanometer Radix Scutellariae 70-110 part
Nanometer Radix Codonopsis 70-110 part nanometer Radix Glycyrrhizae 70-110 part nanometer Rhizoma Zingiberis Recens 70-110 part
Nanometer Fructus Jujubae 70-110 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano bupleurum 230-250 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 80-100 part nanometer Radix Scutellariae 80-100 part
Nanometer Radix Codonopsis 80-100 part nanometer Radix Glycyrrhizae 80-100 part nanometer Rhizoma Zingiberis Recens 80-100 part
Nanometer Fructus Jujubae 80-100 part
The optimum weight proportioning of medicine of the present invention is:
90 parts of 90 parts of nanometer Radix Scutellariaes of 240 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of nano bupleurum
90 parts in 90 portions of nanometer Rhizoma Zingiberis Recenss of 90 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Codonopsis
90 parts in nanometer Fructus Jujubae
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to 0.05MPa the pressure,, get the Herba Sidae Rhombifoliae granule nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the little bupleurum preparation medicine of nanometer is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common Herba Sidae Rhombifoliae granule preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that tablet, suppository, membrane, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup of the little bupleurum preparation medicine of nanometer etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for liver and gall and digestive system disease and fever, infection or diseases associated with inflammation, anaphylaxis dermatosis, climacteric syndrome, the hyperemesis gravidarum, the constitutional neuralgia, treatments such as infectious monocytosis, clinical efficacy significantly is better than traditional Herba Sidae Rhombifoliae granule.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
90 parts of 90 parts of nanometer Radix Scutellariaes of 240 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of nano bupleurum
90 parts in 90 portions of nanometer Rhizoma Zingiberis Recenss of 90 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Codonopsis
90 parts in nanometer Fructus Jujubae
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano material by preceding method:
90 parts of 90 parts of nanometer Radix Scutellariaes of 240 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of nano bupleurum
90 parts in 90 portions of nanometer Rhizoma Zingiberis Recenss of 90 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Codonopsis
90 parts in nanometer Fructus Jujubae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the little Radix Bupleuri powder needle injection of nanometer, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Implement sharp 3:
Prepare nano raw material by preceding method:
90 parts of 90 parts of nanometer Radix Scutellariaes of 240 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of nano bupleurum
90 parts in 90 portions of nanometer Rhizoma Zingiberis Recenss of 90 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Codonopsis
90 parts in nanometer Fructus Jujubae
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the little Radix Bupleuri membrane of nanometer, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part, back, chest.
Claims (6)
1, the little bupleurum preparation medicine of a kind of nanometer is characterized in that it is the medicament that the nano raw material of following weight proportioning is made.
Nano bupleurum 220-260 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 70-110 part nanometer Radix Scutellariae 70-110 part
Nanometer Radix Codonopsis 70-110 part nanometer Radix Glycyrrhizae 70-110 part nanometer Rhizoma Zingiberis Recens 70-110 part
Nanometer Fructus Jujubae 70-110 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30--60 ℃, time is 3--72 hour, collect simultaneously volatile material in the Chinese medicine in addition: decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, the little bupleurum preparation medicine of nanometer according to claim 1, wherein the weight proportion of each nano raw material is:
Nano bupleurum 230-250 part nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 80-100 part nanometer Radix Scutellariae 80-100 part
Nanometer Radix Codonopsis 80-100 part nanometer Radix Glycyrrhizae 80-100 part nanometer Rhizoma Zingiberis Recens 80-100 part
Nanometer Fructus Jujubae 80-100 part
3, the little bupleurum preparation medicine of nanometer according to claim 1, wherein the weight proportion of each nano raw material is:
90 parts of 90 parts of nanometer Radix Scutellariaes of 240 parts of nanometer Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s of nano bupleurum
90 parts in 90 portions of nanometer Rhizoma Zingiberis Recenss of 90 parts of nanometer Radix Glycyrrhizaes of nanometer Radix Codonopsis
90 parts in nanometer Fructus Jujubae
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or the little bupleurum preparation medicine of 2 or 3 described nanometers.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or the little bupleurum preparation medicine of 2 or 3 described nanometers; Place extraction pot, solubilizer also imports microwave extracting, make it do the change in polarity motion with hundred million times/second speed of 20--30, the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour: above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to 0.05MPa the pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100748 CN1362246A (en) | 2001-01-08 | 2001-01-08 | Nano Bupleuric medicine for regulating Shaoyang and it spreparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100748 CN1362246A (en) | 2001-01-08 | 2001-01-08 | Nano Bupleuric medicine for regulating Shaoyang and it spreparation |
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| CN1362246A true CN1362246A (en) | 2002-08-07 |
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| CN 01100748 Pending CN1362246A (en) | 2001-01-08 | 2001-01-08 | Nano Bupleuric medicine for regulating Shaoyang and it spreparation |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526391A (en) * | 2010-12-16 | 2012-07-04 | 天津中敖生物科技有限公司 | Livestock Chinese medicinal composition with refrigerating function and preparation method thereof |
| CN103372193A (en) * | 2012-04-27 | 2013-10-30 | 牛登林 | Medicament for treating fever in children |
-
2001
- 2001-01-08 CN CN 01100748 patent/CN1362246A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526391A (en) * | 2010-12-16 | 2012-07-04 | 天津中敖生物科技有限公司 | Livestock Chinese medicinal composition with refrigerating function and preparation method thereof |
| CN103372193A (en) * | 2012-04-27 | 2013-10-30 | 牛登林 | Medicament for treating fever in children |
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