CN1528436A

CN1528436A - Chinese medicine preparation using rhizoma gastrodiae and eucommia as main material and preparing method thereof

Info

Publication number: CN1528436A
Application number: CNA200310110721XA
Authority: CN
Inventors: 张乐陵
Original assignee: GUIZHOU SANLI PHARMACY Ltd
Current assignee: GUIZHOU SANLI PHARMACY Ltd
Priority date: 2003-10-09
Filing date: 2003-10-09
Publication date: 2004-09-15

Abstract

The present invention relates to a Chinese medicine preparation by using gastrodia root and eucommia bark as main raw material. Said Chinese medicine is made up by using eucommia bark, gastrodia root and Chinese angelica root through a certain preparation process. Said Chinese medicine mainly is used for curing pain of the sinews, numbness of the limbs, hemiplegia, aching lumbus and leg pain and headache which are resulted from wind stroke, and can obtain obvious therapeutic effect. Its disintegration and dissolution speed is quick and its biological utilization rate is high.

Description

It with the gastrodia tuber eucommia Chinese medicine preparation of primary raw material and preparation method thereof

Technical field: the present invention be a kind of be the Chinese medicine preparation and preparation method thereof of primary raw material with the gastrodia tuber eucommia, belong to technical field of Chinese medicines.

Technical background: numb limbs and tense tendons, walking disorder, waist and leg ache, diseases such as headache and dizziness and hypertension are commonly encountered diseases, frequently-occurring disease; Have a strong impact on people's healthy living, treating this class disease is the medicine of taking pure gastrodia capsule one class for Chinese medicine generally, because it is limited that single preparations of ephedrine is renderd a service, particularly some human bodies are for the limitation of its drug effect ability to accept, and are not obvious so effect has; At this time, often the patient can be equipped with and take Western medicine class medicine and treat, because the Western medicine side effect is bigger, so influences the normal function of human body again; Have on the market based on the Chinese medicine preparation of medicines such as Rhizoma Gastrodiae and selling, if ratio of component is more in the prescription, then production cost is higher, quality is restive; This quasi drugs of market sale generally is granular preparation, capsule preparations in addition, and inconvenience taken by the medicine of this class dosage form or the efficacy of a drug is weak, effect is unobvious especially.

Summary of the invention: the objective of the invention is to: providing a kind of is the Chinese medicine preparation of primary raw material and other preparation method with the gastrodia tuber eucommia, medicament selection Rhizoma Gastrodiae of the present invention, the Cortex Eucommiae and Radix Angelicae Sinensis make up, thereby make each flavour of a drug effect produce synergism these flavour of a drug combinations and can effectively treat numb limbs and tense tendons, walking disorder, waist and leg ache, headache and dizziness and hypertension.Wherein select for use the Rhizoma Gastrodiae nature and flavor sweet flat, return Liver Channel, the suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion, it is dizzy to be used to have a headache, numb limbs and tense tendons; The Cortex Eucommiae is sweet in flavor and warm in property, returns the Liver and kidney warp, invigorating the liver and kidney, and bone and muscle strengthening is used for lumbago due to renal deficiency, and muscles and bones is unable, hypertension; Radix Angelicae Sinensis nature and flavor Gan Xinwen, GUIXIN liver spleen channel, the promoting blood circulation and stopping pain of enriching blood is used for blood deficiency and yellow complexion, dizzy cardiopalmus, rheumatic arthralgia.All medicines share to be played the wind that looses altogether and invigorates blood circulation the effect of the meridian and relieving pain that relaxes; In order to heighten the effect of a treatment, medicine of the present invention also makes up with Radix Angelicae Pubescentis, Herba Visci, Rhizoma Et Radix Notopterygii, Rhizoma Ligustici, because the arduous tepor of Radix Angelicae Pubescentis nature and flavor is returned the kidney urinary bladder channel, and expelling wind and removing dampness, numbness relieving and pain relieving is used for anemofrigid-damp arthralgia, lumbocrural pain, few sun volt wind headache; The sweet acid of Herba Visci nature and flavor is cold, returns the Liver and kidney warp, and nourishing the liver and kidney is used for vertigo and tinnitus, soreness of the waist and knees; The arduous temperature of Rhizoma Et Radix Notopterygii nature and flavor is returned the kidney urinary bladder channel, and cold expelling dispels the wind, dehumidifying, and pain relieving is used for headche due to wind-cold, rheumatic arthralgia, aching pain in should and back; The Rhizoma Ligustici property and flavor of peppery and warm is returned urinary bladder channel, dispels the wind, and cold expelling, dehumidifying, pain relieving is used for top of the head pain, rheumatism podomere arthralgia pain.

More than the common assistant of four flavors help the monarch and his subjects' the product wind that looses to invigorate blood circulation the merit of the meridian and relieving pain that relaxes.In order to reach better therapeutic, medicine of the present invention has increased Radix Aconiti Kusnezoffii Preparata and Radix Aconiti Lateralis Preparata on the combinations thereof basis, because the arduous heat of Radix Aconiti Kusnezoffii Preparata nature and flavor, GUIXIN liver spleen kidney channel, expelling wind and removing dampness, antalgic is used for anemofrigid-damp arthralgia, arthralgia; The big heat of Radix Aconiti Lateralis Preparata acrid-sweet flavor, GUIXIN kidney spleen channel, it is supporing yang to mend fire, by wind-cold damp pathogen, is used for the cold extremities faint pulse, arthralgia due to cold-dampnes.More than the common assistant of two flavors help its diffusing wind removing damp and stopping pain, the power in sharp joint.In order to obtain optimum curative effect, medicine of the present invention has increased Radix Scrophulariae and Radix Rehmanniae on combinations thereof Ji Chu, because Radix Scrophulariae nature and flavor sweetness and bitterness is salty, returns lung stomach kidney channel, and the removing heat from blood YIN nourishing is used for consumption of YIN caused by febrile disease, carbuncle; Radix Rehmanniae is sweet in flavor and cold in property, GUIXIN Liver and kidney warp, and clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting is used for interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever.Make it with this two flavor, thereby reach the YIN nourishing removing heat from blood, the merit of subduing swelling and relieving pain.

The present invention constitutes like this: with the gastrodia tuber eucommia is the Chinese medicine preparation of primary raw material, and it mainly is to be made by following bulk drugs: 6～14 parts of 4～12 parts in Rhizoma Gastrodiae, 4～12 parts of the Cortexs Eucommiae and Radix Angelicae Sinensis.Specifically: it mainly is to be made by following bulk drugs: 10 parts of 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae and Radix Angelicae Sinensis.This be the preparation method of the Chinese medicine preparation of primary raw material: a with the gastrodia tuber eucommia, take by weighing each crude drug Rhizoma Gastrodiae, the Cortex Eucommiae and Radix Angelicae Sinensis, standby; B, Rhizoma Gastrodiae powder is broken into fine powder, Radix Angelicae Sinensis extracts volatile oil, and its medicinal residues and the Cortex Eucommiae are decocted with water twice, merge twice decocting liquid, filter, filtrate is condensed into cream, mixes with the Rhizoma Gastrodiae fine powder that obtains, drying, is ground into the active constituent that powder just has been prepared into medicine of the present invention.In the Chinese medicine preparation that with the gastrodia tuber eucommia is primary raw material, also have: 2～9 parts of 3～7 parts of Radix Angelicae Pubescentiss, 2～9 parts of Herba Viscis, 6～14 parts of Rhizoma Et Radix Notopterygiis and Rhizoma Ligusticis.Specifically: wherein the consumption of each component is: 6 parts of 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Angelicae Pubescentiss, 6 parts of Herba Viscis, 10 parts of Rhizoma Et Radix Notopterygiis and Rhizoma Ligusticis.In this case with the gastrodia tuber eucommia be that the preparation method of the Chinese medicine preparation of primary raw material comprises the following steps: a, takes by weighing Rhizoma Gastrodiae, the Cortex Eucommiae, Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Herba Visci, Rhizoma Et Radix Notopterygii and Rhizoma Ligustici, standby; B, get Rhizoma Gastrodiae powder and be broken into fine powder, extract volatile oil from Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii, the residual medicine dreg and the Cortex Eucommiae, Herba Visci add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with Rhizoma Gastrodiae medicated powder combination drying, pulverize, cross 100 mesh sieves, get extract powder, just be prepared into the active constituent of medicine of the present invention.This is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, wherein also has in the crude drug: 0.5～1.5 part of Radix Aconiti Kusnezoffii Preparata, 0.5～1.5 part of Radix Aconiti Lateralis Preparata.Specifically: wherein the consumption of each component is: 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Angelicae Pubescentiss, 6 parts of Herba Viscis, 10 parts of Rhizoma Et Radix Notopterygiis, 6 parts of Rhizoma Ligusticis, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Radix Aconiti Lateralis Preparata.It is the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia: take by weighing each crude drug according to given ratio, get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, and the medicinal residues and the Cortex Eucommiae, Herba Visci, Radix Aconiti Kusnezoffii Preparata and Radix Aconiti Lateralis Preparata add water, decoct two

Inferior, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverizes, and crosses 100 mesh sieves, extract powder, just be prepared into the active constituent of medicine of the present invention.In the Chinese medicine preparation that originally is primary raw material, also have in the crude drug: 2～9 parts of Radix Scrophulariaes, 12～20 parts of Radix Rehmanniae with the gastrodia tuber eucommia.The consumption of each more specific component is: 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Angelicae Pubescentiss, 6 parts of Herba Viscis, 10 parts of Rhizoma Et Radix Notopterygiis, 6 parts of Rhizoma Ligusticis, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Radix Aconiti Lateralis Preparata, 6 parts of Radix Scrophulariaes, 16 parts of Radix Rehmanniae.Its preparation method is: take by weighing each crude drug according to given ratio, get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, the medicinal residues and the Cortex Eucommiae, Herba Visci, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, Radix Scrophulariae and Radix Rehmanniae add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverizes, cross 100 mesh sieves, promptly get extract powder, just be prepared into the active constituent of medicine of the present invention.Utilizing this is the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, the active component that makes can be made into oral formulations, comprises with soft capsule preparation adjuvant commonly used being made into soft capsule preparation.

Compared with prior art: product character provided by the invention: be soft capsule, content is the thick extractum of sepia, gas perfume (or spice), sweet in the mouth.Function cures mainly: diffusing wind is invigorated blood circulation, muscles and tendons relaxing to alleviate pain.Be used for wind-induced ache tendon and vessel, numb limbs and tense tendons, walking disorder, waist and leg ache, headache and dizziness etc.Usage and dosage: oral (soft capsule), one time 4～6,2 times on the 1st.Appearance of the present invention is neat and artistic, covers the uncomfortable taste of medicine, swallows easily; Remedy the deficiency of other dosage form, be convenient to store and carry; Improve medicine stability; Drug particles is thin, even, and disintegrate is molten looses soon the drug bioavailability height.Soft capsule is the advanced dosage form of Chinese medicine, and is with high content of technology, and the Chinese medicinal soft capsule kind is few at present.The hard capsule poor stability, the moisture absorption is rotten easily, and content is a grease in the soft capsule, is difficult for the moisture absorption, good stability.Contain volatile oil in this product, then sealing is poor to make hard capsule, easily volatilization, and make soft capsule increase seal with prevent volatile ingredient wave diffusing, thereby improve product stability.The hard capsule content is a granule, and drug effect is slow after the medication, and bioavailability is low; Soft capsule content is almost micron or nano material, and drug effect is rapid after the medication, and the bioavailability height; So we select to be prepared into soft capsule when product ommercialization.

Embodiments of the invention 1: get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, seven flavors such as the medicinal residues and the Cortex Eucommiae, add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverize, cross 100 mesh sieves, promptly get extract powder.Get extract powder, volatile oil and vegetable oil (or Polyethylene Glycol), Cera Flava by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the content fill is pressed into 1000 soft capsules, typing below 25 ℃, soft with the ethanol flush away

Capsule appearance oil reservoir in dry below 25 ℃, takes out promptly.

Embodiments of the invention 2: according to given ratio, Rhizoma Gastrodiae powder is broken into micropowder more than 200 orders, and Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, and medicinal residues and the Cortex Eucommiae etc. seven are distinguished the flavor of, add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, the filtrate spray drying gets extract powder, with the Rhizoma Gastrodiae powder mixing.Get and mix extract powder, volatile oil and vegetable oil (or Polyethylene Glycol), Cera Flava by making suspended matter at 1: 1: 0.02, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the content fill is pressed into 1000 soft capsules, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out promptly.

The present invention is that preparation process research is carried out on the basis with best preferred compositions prescription, in this way to all the other combined preparation processing, its method unanimity.

Embodiments of the invention 3: Rhizoma Gastrodiae powder is broken into coarse powder, according to the percolation under fluid extract and the extractum item, makes solvent with 60% ethanol, floods and carries out percolation after 24 hours, collects the liquid of filtering, and concentrating under reduced pressure becomes extractum I.Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, and seven flavors such as the medicinal residues and the Cortex Eucommiae add water, decoct twice, and 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, spray drying gets extract powder behind filtrate and the extractum I mixing.Get extract powder, volatile oil and vegetable oil (or Polyethylene Glycol), Cera Flava by making suspended matter at 3: 2: 0.04, with gelatin: glycerol: water is that 1: 0.35: 0.9 ratio prepares rubber, then the content fill is pressed into 500 soft capsules, typing below 25 ℃, with ethanol flush away soft capsule appearance oil reservoir, in dry below 25 ℃, take out promptly.

Embodiments of the invention 4: get 10 kilograms of 8 kilograms in Rhizoma Gastrodiae, 8.5 kilograms of the Cortexs Eucommiae and Radix Angelicae Sinensis.Carry out according to the following step: a, take by weighing each crude drug Rhizoma Gastrodiae, the Cortex Eucommiae and Radix Angelicae Sinensis, standby; B, Rhizoma Gastrodiae powder is broken into fine powder, Radix Angelicae Sinensis extracts volatile oil, its medicinal residues and the Cortex Eucommiae are decocted with water twice, merge twice decocting liquid, filter, filtrate is condensed into cream, mix with the Rhizoma Gastrodiae fine powder that obtains, dry, be ground into the active constituent that powder just has been prepared into medicine of the present invention, be made into granular preparation according to prior art again.

Embodiments of the invention 5: get 6 kilograms of 8 kilograms in Rhizoma Gastrodiae, 8.5 kilograms of the Cortexs Eucommiae, 10 kilograms of Radix Angelicae Sinensis, 5 kilograms of Radix Angelicae Pubescentiss, 6 kilograms of Herba Viscis, 10 kilograms of Rhizoma Et Radix Notopterygiis and Rhizoma Ligusticis; According to the following step: a, take by weighing Rhizoma Gastrodiae, the Cortex Eucommiae, Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Herba Visci, Rhizoma Et Radix Notopterygii and Rhizoma Ligustici, standby; B, get Rhizoma Gastrodiae powder and be broken into fine powder, extract volatile oil from Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii, the residual medicine dreg and the Cortex Eucommiae, Herba Visci add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with Rhizoma Gastrodiae medicated powder combination drying, pulverize, cross 100 mesh sieves, get extract powder, just be prepared into the active constituent of medicine of the present invention; Be made into oral liquid formulations according to prior art again.

Embodiments of the invention 6: 8 kilograms in Rhizoma Gastrodiae, 8.5 kilograms of the Cortexs Eucommiae, 10 kilograms of Radix Angelicae Sinensis, 5 kilograms of Radix Angelicae Pubescentiss, 6 kilograms of Herba Viscis, 10 kilograms of Rhizoma Et Radix Notopterygiis, 6 kilograms of Rhizoma Ligusticis, 1 kilogram of Radix Aconiti Kusnezoffii Preparata, 1 kilogram of Radix Aconiti Lateralis Preparata; Get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, and the medicinal residues and the Cortex Eucommiae, Herba Visci, Radix Aconiti Kusnezoffii Preparata and Radix Aconiti Lateralis Preparata add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverizes, cross 100 mesh sieves, extract powder, just be prepared into the active constituent of medicine of the present invention; Be prepared into the dosage form that needs then as required.

Embodiments of the invention 7: claim 8 kilograms in Rhizoma Gastrodiae, 8.5 kilograms of the Cortexs Eucommiae, 10 kilograms of Radix Angelicae Sinensis, 5 kilograms of Radix Angelicae Pubescentiss, 6 kilograms of Herba Viscis, 10 kilograms of Rhizoma Et Radix Notopterygiis, 6 kilograms of Rhizoma Ligusticis, 1 kilogram of Radix Aconiti Kusnezoffii Preparata, 1 kilogram of Radix Aconiti Lateralis Preparata, 6 kilograms of Radix Scrophulariaes, 16 kilograms of Radix Rehmanniae; Get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, the medicinal residues and the Cortex Eucommiae, Herba Visci, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, Radix Scrophulariae and Radix Rehmanniae, add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverize, cross 100 mesh sieves, promptly get extract powder, just be prepared into the active constituent of medicine of the present invention; Be prepared into the dosage form that needs then as required.

Drug efficacy study

For estimating this curative effect of medication, according to main pharmacodynamics investigative technique requirement the carrying out pharmacological testing research of apoplexy, be subjects with the rat, adopt ligation rat bilateral carotid arteries test method, its result is as follows:

This test was taked ischemia 16 hours, visible 46.56% cranial nerve cell necrosis under light microscopic, 32.89% cranial nerve cell degeneration, only deposit 20.55% normal brain activity cell, with sham operated rats highly significant difference (P＜0.001) is arranged relatively, after showing that ligation rat bilateral carotid arteries reaches 16 hours, caused the rat cerebral ischemia damage.Give the rats gavaged medicine after 5 days continuously, compare with matched group, administration group cerebral tissue non-viable non-apoptotic cell obviously reduces (P＜0.05) normal cell and increases (P＜0.05), and cerebral tissue lipid peroxide (LPO) growing amount reduces (P＜0.05).Simultaneously the inductive platelet aggregation of ADP there is remarkable inhibitory action.Show that this medicine has obvious protective effect to ischemic tissue of brain, and have function of promoting blood circulation to disperse blood clots that prompting this product is relevant with above-mentioned effect to the therapeutical effect of apoplexy and sequela thereof.

Toxicity research

For estimating the toxic and side effects of this medicine, instruct clinical application, require to carry out toxicological test research according to the drug toxicology investigative technique, be subjects with rat and mice, its result is as follows:

(1) acute toxicity test: the clinical recommendation consumption of this medicine is 4.8g/d (12/day, the 0.4g/ grain), is the 60kg conversion to become body weight for humans, is equivalent to 0.08g/kg.d.The maximum dosage of this test mice is that the maximum dosage of 64g/kg.d, rat is 60g/kg.d (allowing maximum stomach concentration and the maximum stomach volume of irritating of irritating to reach), be equivalent to 800 and 750 times of clinical consumption respectively, do not see in observation period that toxic reaction and death appear in animal, show this product oral medication safety.

(1) long term toxicity test: rat is irritated stomach every day and gives and this medicine 0.4g/kg, 1.0g/kg, 2.0g/kg, is respectively 10 times, 25 times and 50 times of clinical medicine dose, establishes a physiology saline control group simultaneously, 12 weeks of continuous use.Outward appearance, behavior, feed and the defecation of each administration group rat are normal in observation period, body weight gain and internal organs coefficient and matched group basically identical, none animal dead.All in normal range, main organs gross necropsy and histopathology microscopy are not seen obvious pathological change for the hemogram of each medication group, liver function, renal function, compare no significant difference with matched group.Show this product oral by the dosage of recommending and the course of treatment be safe.

Clinical efficacy research

For further estimating this curative effect of medication, carry out clinical experimental study according to the Clinical Researches of New Drugs specification requirement, its result is as follows:

(1) health giving quality result

1, clinical efficacy: this study population 315 examples, clinical efficacy total effective rate are 89.84%.

2, tcm syndrome curative effect: this study population 315 examples, tcm syndrome curative effect total effective rate is 93.02%.

3, neurological functional deficit curative effect: function of nervous system's single index and comprehensive neurological functional deficit are estimated comparing difference before and after the patient treatment all statistical significance, show the apoplexy neurological deficit is all had some improvement, and can improve patient's viability state, clinical treatment meaning is preferably arranged.

4, tcm clinical practice symptom curative effect: tcm clinical practice symptom single index and aggregative indicator total mark are estimated comparing difference before and after the patient treatment all statistical significance, show the ache tendon and vessel that paralytic's traditional Chinese medical science is belonged to deficiency of the liver and kindey, syndrome of upper hyperactivity of liver yang patient performance, numb limbs and tense tendons, walking disorder, waist and leg ache, symptoms such as headache and dizziness all have some improvement and comprehensive improvement effect, and clinical treatment meaning is preferably arranged.

5, blood pressure curative effect: the analysis of blood pressure result to patient before and after the treatment shows that patient's hypertension all has decline, and prompting has the clinical treatment meaning to paralytic's hypertension.

6, apoplexy curative effect by stages: stroke in convalescent stage and sequela stage clinical efficacy are identical, and curative effect is preferably all arranged, but to reconvalescent's clinical symptoms improve and curative effect better.

7, treatment group Western medicine diagnose curative effect of disease: the clinical and tcm syndrome of cerebral hemorrhage and Cerebral Infarction Patients all has curative effect preferably.

(2) safety results

Vital sign and lab testing result show no obvious toxic-side effects in the clinical use of 315 routine patients.

(3), conclusion

This medicine has expelling wind and activating blood circulation, the effect of the meridian and relieving pain that relaxes, and the clinical apoplexy traditional Chinese medical science that is used for belongs to the ache tendon and vessel that deficiency of the liver and kindey, syndrome of upper hyperactivity of liver yang cause, numb limbs and tense tendons, walking disorder, waist and leg ache, headache and dizziness and hypertension etc., evident in efficacy, no obvious toxic-side effects.

Claims

1, a kind of is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: it mainly is to be made by following bulk drugs: 6～14 parts of 4～12 parts in Rhizoma Gastrodiae, 4～12 parts of the Cortexs Eucommiae and Radix Angelicae Sinensis.

2, described according to claim 1 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, and it is characterized in that: it mainly is to be made by following bulk drugs: 10 parts of 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae and Radix Angelicae Sinensis.

3, according to claim 1 or 2 described be the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: a, take by weighing each crude drug Rhizoma Gastrodiae, the Cortex Eucommiae and Radix Angelicae Sinensis, standby; B, Rhizoma Gastrodiae powder is broken into fine powder, Radix Angelicae Sinensis extracts volatile oil, and its medicinal residues and the Cortex Eucommiae are decocted with water twice, merge twice decocting liquid, filter, filtrate is condensed into cream, mixes with the Rhizoma Gastrodiae fine powder that obtains, drying, is ground into the active constituent that powder just has been prepared into medicine of the present invention.

4, described according to claim 1 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: wherein also have in the crude drug: 2～9 parts of 3～7 parts of Radix Angelicae Pubescentiss, 2～9 parts of Herba Viscis, 6～14 parts of Rhizoma Et Radix Notopterygiis and Rhizoma Ligusticis.

5, described according to claim 4 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, and it is characterized in that: wherein the consumption of each component is: 6 parts of 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Angelicae Pubescentiss, 6 parts of Herba Viscis, 10 parts of Rhizoma Et Radix Notopterygiis and Rhizoma Ligusticis.

6, according to claim 4 or 5 described be the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: it comprises the following steps: a, takes by weighing Rhizoma Gastrodiae, the Cortex Eucommiae, Radix Angelicae Sinensis, Radix Angelicae Pubescentis, Herba Visci, Rhizoma Et Radix Notopterygii and Rhizoma Ligustici, and is standby; B, get Rhizoma Gastrodiae powder and be broken into fine powder, extract volatile oil from Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis and Rhizoma Et Radix Notopterygii, the residual medicine dreg and the Cortex Eucommiae, Herba Visci add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with Rhizoma Gastrodiae medicated powder combination drying, pulverize, cross 100 mesh sieves, get extract powder, just be prepared into the active constituent of medicine of the present invention.

7, described according to claim 4 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: wherein also have in the crude drug: 0.5～1.5 part of Radix Aconiti Kusnezoffii Preparata, 0.5～1.5 part of Radix Aconiti Lateralis Preparata.

8, described according to claim 7 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, and it is characterized in that: wherein the consumption of each component is: 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Angelicae Pubescentiss, 6 parts of Herba Viscis, 10 parts of Rhizoma Et Radix Notopterygiis, 6 parts of Rhizoma Ligusticis, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Radix Aconiti Lateralis Preparata.

9, according to claim 7 or 8 described be the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: take by weighing each crude drug according to given ratio, get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii are extracted volatile oil, the medicinal residues and the Cortex Eucommiae, Herba Visci, Radix Aconiti Kusnezoffii Preparata and Radix Aconiti Lateralis Preparata add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverizes, cross 100 mesh sieves, extract powder, just be prepared into the active constituent of medicine of the present invention.

10, described according to claim 7 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: wherein also have in the crude drug: 2～9 parts of Radix Scrophulariaes, 12～20 parts of Radix Rehmanniae.

11, described according to claim 10 is the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, and it is characterized in that: wherein the consumption of each component is: 8 parts in Rhizoma Gastrodiae, 8.5 parts of the Cortexs Eucommiae, 10 parts of Radix Angelicae Sinensis, 5 parts of Radix Angelicae Pubescentiss, 6 parts of Herba Viscis, 10 parts of Rhizoma Et Radix Notopterygiis, 6 parts of Rhizoma Ligusticis, 1 part of Radix Aconiti Kusnezoffii Preparata, 1 part of Radix Aconiti Lateralis Preparata, 6 parts of Radix Scrophulariaes, 16 parts of Radix Rehmanniae.

12, according to claim 10 or 11 described be the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: take by weighing each crude drug according to given ratio, get Rhizoma Gastrodiae powder and be broken into fine powder, Radix Angelicae Pubescentis, Rhizoma Ligustici, Radix Angelicae Sinensis, Rhizoma Et Radix Notopterygii is extracted volatile oil, the medicinal residues and the Cortex Eucommiae, Herba Visci, Radix Aconiti Kusnezoffii Preparata, Radix Aconiti Lateralis Preparata, Radix Scrophulariae and Radix Rehmanniae, add water, decoct twice, 3 hours for the first time, 1 hour for the second time, merge decocting liquid twice, filter, filtrate is condensed into cream, with above-mentioned medicated powder combination drying, pulverize, cross 100 mesh sieves, promptly get extract powder, just be prepared into the active constituent of medicine of the present invention.

13, according to claim 3,6,9 or 11 described be the preparation method of the Chinese medicine preparation of primary raw material with the gastrodia tuber eucommia, it is characterized in that: the active component that makes is made into oral formulations, comprises with soft capsule preparation adjuvant commonly used being made into soft capsule preparation.