CN1498535A - Method for preparing stable water insoluble microemulsion fluid of ramification of isothiazolin - Google Patents
Method for preparing stable water insoluble microemulsion fluid of ramification of isothiazolin Download PDFInfo
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- CN1498535A CN1498535A CNA021464286A CN02146428A CN1498535A CN 1498535 A CN1498535 A CN 1498535A CN A021464286 A CNA021464286 A CN A021464286A CN 02146428 A CN02146428 A CN 02146428A CN 1498535 A CN1498535 A CN 1498535A
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- isothiazolinone
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Abstract
A process for preparing the high-stability water-insulble microsuspension of isothiazolinone derivative features that under the existance of solvent, cosolvent and surfactant, the water-insoluble isothiazolinone derivative is used to prepare said microsuspension.
Description
The present invention relates to the preparation of water-insoluble isothiazolinone microemulsion, this microemulsion can directly or be used for the occasion that papermaking, Treatment of Industrial Water, coating etc. need sterilization processing behind the dilute with water.This microemulsion especially has effectively peels off mud, the good result of kill bacteria, fungi, algae etc. in water treatment procedure.
As everyone knows, the isothiazolinone compounds is to use at present a series bactericidal agent very widely, 5-chloro-2-methyl-4-isothiazoline-3-ketone (CMI) and 2-methyl-4-isothiazoline-3-ketone (MI) with the product of 3: 1 ratios in the commercial great success that obtained.And other have the iso thiazoline ketone compound of better bactericidal effect, for example 4, and 5-two chloro-2-n-octyls-4-isothiazoline-3-ketone (DOI), reason such as, product poorly water-soluble higher owing to manufacturing requirements fails to obtain excellent popularization at home always.
Patent CN1038978C has described the process for preparation of 20-30%DOI concentrate, but owing to used the very expensive methyl naphthalene of price, it is restricted on practicality.Owing to the good sterilizing ability of DOI, also need not to use the product of high concentration like this in actual the use simultaneously.
The present invention proposes the microemulsion prescription of a kind of like this DOI, and active component content is about 0.5-18%, and such concentration enough satisfies the application need in most occasions, and stoste and dilution have stability for storage.Its objective is both to can be used for directly adding, also can dilute the back and use.
Prescription of the present invention comprises following several composition:
(1) DOI or OIT;
(2) be used to dissolve the organic solvent of DOI or OIT;
(3) cosolvent;
(4) non-ionic surface active agent;
(5) ionic surfactant;
(6) deionized water.
Solvent of the present invention is selected from next group material:
Benzylalcohol, toluene, dimethylbenzene, trimethylbenzene, aromatic solvent naphtha, dichloroethane, dichloropropane, trichloropropane, butyl acetate, diisooctyl phthalate, dioctyl phthalate.
Cosolvent of the present invention is selected from next group material:
Ethylene glycol, glycol monomethyl ether, glycol dimethyl ether, ethylene glycol monobutyl ether (EGMBE), butyl cellosolve, diethylene glycol, propane diols, propane diols monomethyl ether, Propylene Glycol Dimethyl Ether, dipropylene glycol.
Non-ionic surface active agent of the present invention is selected from next group material:
The ethylene glycol APEO, the ethylene glycol polyoxyethylene poly-oxygen propylene aether, the propane diols APEO, the propane diols polyoxyethylene poly-oxygen propylene aether, nonyl phenol APEO, nonyl phenol polyoxyethylene poly-oxygen propylene aether, the octyl phenol APEO, the octyl phenol polyoxyethylene poly-oxygen propylene aether, polyoxyethylene glycerol ether, castor oil polyoxyethylene ether.
Ionic surfactant of the present invention is selected from next group material:
Alkylbenzenesulfonate, polyoxyethylene alkylphenol ether sulphate, quaternary ammonium salt compound.
Ionic surfactant of the present invention is preferably from organizing material with next:
Neopelex, 12～stearyl dimethyl benzyl ammonium chloride, 12～OTAC, two eight～eicosyl alkyl dimethyl ammonium chlorides.
The relative amount of various components is in the described microemulsion:
DOI or OIT 0.5-18%
Solvent 10-20%
Cosolvent 10-20%
Surfactant 15-45%
Deionized water 30-60%
Embodiment 1:
The preparation of 5%DOI microemulsion
Various raw materials add in following ratio, preparation DOI emulsion 1000g:
| DOI | 50g |
| Benzylalcohol | 110g |
| Glycol dimethyl ether | 135g |
| 1,2-propane diols polyoxyethylene poly-oxygen propylene aether | 120g |
| Dodecyl benzyl dimethyl ammonium chloride | 58g |
| Neopelex | 30g |
| Silicone defoaming agent | 2g |
| Deionized water | 495g |
This sample can be preserved under 50 ℃ and reach 138 days and do not occur being separated, and still remains with 4.57% active component content (HPLC).
Embodiment 2:
The preparation of 0.5%DOI dilution
Get the sample 100g of the foregoing description 1, add deionized water 900g, dispersed with stirring.
This sample can be preserved under 50 ℃ and reach 73 days and do not occur being separated, and still remains with 0.45% active component content (HPLC).
The detailed description that the present invention did, be enough to make those skilled in the art can utilize method of the present invention, but from the front disclosed content still can obviously find out various replacements, revise do not break away from the spirit and scope of the present invention with improved method.
Claims (10)
1. a stable water-insoluble isothiazolinone derivatives microemulsion composition comprises water-insoluble isothiazolinone derivatives, solvent, cosolvent, surfactant and deionized water in the said composition.
2. the described microemulsion composition of claim 1 comprises following component in the said composition:
(1) 4,5-two chloro-2-n-octyls-4-isothiazoline-3-ketone (DOI) or 2-n-octyl-4-isothiazoline-3-ketone (OIT);
(2) be used to dissolve the solvent of above-mentioned isothiazolinone;
(3) be used to form the cosolvent of above-mentioned isothiazolinone microemulsion;
(4) non-ionic surface active agent;
(5) ionic surfactant;
(6) deionized water.
3. the described composition of claim 1, described isothiazolinone content is 0.5～18%, both can be directly used in the sterilization occasion, also can dilute the back and use.
4. the described composition of claim 1, wherein solvent is selected from following one group of material: benzylalcohol, toluene, dimethylbenzene, trimethylbenzene, aromatic solvent naphtha, dichloroethane, dichloropropane, trichloropropane, butyl acetate, diisooctyl phthalate, dioctyl phthalate.
5. the described composition of claim 1, wherein cosolvent is selected from following one group of material: ethylene glycol, glycol monomethyl ether, glycol dimethyl ether, ethylene glycol monobutyl ether (EGMBE), butyl cellosolve, diethylene glycol, propane diols, the propane diols monomethyl ether, Propylene Glycol Dimethyl Ether, dipropylene glycol.
6. the composition of claim 1, wherein non-ionic surface active agent is selected from following one group of material: the ethylene glycol APEO, the ethylene glycol polyoxyethylene poly-oxygen propylene aether, propane diols APEO, propane diols polyoxyethylene poly-oxygen propylene aether, the nonyl phenol APEO, the nonyl phenol polyoxyethylene poly-oxygen propylene aether, octyl phenol APEO, octyl phenol polyoxyethylene poly-oxygen propylene aether, polyoxyethylene glycerol ether, castor oil polyoxyethylene ether.
7. the described composition of claim 1, wherein ionic surfactant is selected from: alkylbenzenesulfonate, polyoxyethylene alkylphenol ether sulphate, quaternary ammonium salt compound.
8. the described composition of claim 1, wherein ionic surfactant is preferably from following one group of material: neopelex, 12～stearyl dimethyl benzyl ammonium chloride, 12～OTAC, two eight～eicosyl alkyl dimethyl ammonium chlorides.
9. the composition of claim 1, application is papermaking, water treatment, coating, printing ink, leather, textile industry.
10. the composition of claim 1, especially can be used in the water treatment field sterilization, remove algae and mud is peeled off.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021464286A CN1498535A (en) | 2002-11-07 | 2002-11-07 | Method for preparing stable water insoluble microemulsion fluid of ramification of isothiazolin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA021464286A CN1498535A (en) | 2002-11-07 | 2002-11-07 | Method for preparing stable water insoluble microemulsion fluid of ramification of isothiazolin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1498535A true CN1498535A (en) | 2004-05-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA021464286A Pending CN1498535A (en) | 2002-11-07 | 2002-11-07 | Method for preparing stable water insoluble microemulsion fluid of ramification of isothiazolin |
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| CN (1) | CN1498535A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103317566A (en) * | 2013-06-28 | 2013-09-25 | 北京林业大学 | Micro-emulsion-type wood and bamboo mould-proof agent, as well as preparation method and application thereof |
| CN105072905A (en) * | 2013-03-28 | 2015-11-18 | 罗门哈斯公司 | Synergistic combination of a flurochloridone compound and oit for dry film protection |
| CN106614639A (en) * | 2016-12-26 | 2017-05-10 | 常熟市胜阳干燥剂贸易有限公司 | Broad-spectrum high-efficiency safe mildewproof material |
| CN110037041A (en) * | 2019-04-30 | 2019-07-23 | 三河市霍夫曼化学品制造有限公司 | A kind of isothiazolinone built-up microemulsion type biocide mildewcide, preparation method and application |
| CN113305962A (en) * | 2021-07-01 | 2021-08-27 | 黄山市竹溪堂徽雕艺术有限公司 | Anti-corrosion anti-cracking agent for bamboo and wood artware and preparation method thereof |
| CN113455514A (en) * | 2021-06-28 | 2021-10-01 | 陕西西大华特科技实业有限公司 | Agricultural application of bactericidal compound 4, 5-dichloro-2-n-octyl-4-isothiazoline-3-ketone |
-
2002
- 2002-11-07 CN CNA021464286A patent/CN1498535A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105072905A (en) * | 2013-03-28 | 2015-11-18 | 罗门哈斯公司 | Synergistic combination of a flurochloridone compound and oit for dry film protection |
| CN105072905B (en) * | 2013-03-28 | 2017-10-31 | 罗门哈斯公司 | Fluorochloridone compound and OIT synergistic combination are protected for dry film |
| CN103317566A (en) * | 2013-06-28 | 2013-09-25 | 北京林业大学 | Micro-emulsion-type wood and bamboo mould-proof agent, as well as preparation method and application thereof |
| CN103317566B (en) * | 2013-06-28 | 2015-12-23 | 北京林业大学 | A kind of micro-emulsion-type wood bamboo mould-proof agent, and its preparation method and application |
| CN106614639A (en) * | 2016-12-26 | 2017-05-10 | 常熟市胜阳干燥剂贸易有限公司 | Broad-spectrum high-efficiency safe mildewproof material |
| CN110037041A (en) * | 2019-04-30 | 2019-07-23 | 三河市霍夫曼化学品制造有限公司 | A kind of isothiazolinone built-up microemulsion type biocide mildewcide, preparation method and application |
| CN113455514A (en) * | 2021-06-28 | 2021-10-01 | 陕西西大华特科技实业有限公司 | Agricultural application of bactericidal compound 4, 5-dichloro-2-n-octyl-4-isothiazoline-3-ketone |
| CN113305962A (en) * | 2021-07-01 | 2021-08-27 | 黄山市竹溪堂徽雕艺术有限公司 | Anti-corrosion anti-cracking agent for bamboo and wood artware and preparation method thereof |
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