CN1488297A - Health food for cancer patient and preparing method thereof - Google Patents
Health food for cancer patient and preparing method thereof Download PDFInfo
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- CN1488297A CN1488297A CNA031461883A CN03146188A CN1488297A CN 1488297 A CN1488297 A CN 1488297A CN A031461883 A CNA031461883 A CN A031461883A CN 03146188 A CN03146188 A CN 03146188A CN 1488297 A CN1488297 A CN 1488297A
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Abstract
The invention discloses a health product for cancer patients and preparing method. It is made of semen coilis, Ganodorma lucidum, mushroom, ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, Radix astragali, liquorice, lily and haw. It can be made into capsule, infusion preparation, oral liquid, tablet or biscuit, and drink. It has functions of benefiting Qi, tonifying spleen, excreting dampness, and adjusting immunity of economy.
Description
Invention field
The present invention relates to a kind of health product, specifically, is that a kind of cancer patient uses health product, the invention still further relates to the preparation method of these health product.
Background technology
Malignant tumor be in the world with the disease of China's serious threat health of people and life, mortality rate is listed in first and second position of the various causes of death, sickness rate is more than 1,00/,100,000 populations.And trend of rising is gradually arranged.Malignant tumor invasion and attack human body can directly be invaded internal organs, destroys the complete sum function of organ, and damage patient's healthy energy such as spleen and stomach function weaken, and also damage body's immunological function, make it low.In the operation of tumor, radiotherapy process, many patients' healthy energy is that immunologic function, organ dysfunction also damage.The organism metabolism miopragia, resistance against diseases descends.On the therapeutic treatment, adopt immunomodulator to improve immunity at present, Chinese medicine compensate qi and blood and function and immunologic function are to strengthen patient's body organ function and resistance against diseases.As celestial board Ganoderma tea, Ganoderma spore powder etc.These can assisted surgery, chemicotherapy etc. regulated the tumour patient body function, improves the life quality, life-saving of cancer patient etc.
Therapeutic effect of malignant tumour increases year by year, but cure rate is still very low, and patient's slight illness is very big in the treatment of operation and chemicotherapy, has a delicate constitution.So not only need to work out curative effect high treatment method for cancer and medicine, also need appropriate health product, treat cancer together with auxiliary above-mentioned and other cancer therapy drugs.The inventor develops a kind of cancer patient and uses health product, thereby finished the present invention through toxicity test and the clinical verification of repeated clinical practice, animal.
Summary of the invention
The purpose of this invention is to provide the auxiliary tumour patient of a kind of energy and improve body function, improve immunity, improve the health product of its quality of life.
Another object of the present invention provides the preparation method of described health product.
The present invention has selected for use some toxicity of Medicine Food Homology very little or almost not have toxic Chinese medicine, these Chinese medicines be Semen Coicis, Ganoderma, Lentinus Edodes, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the Radix Astragali, Radix Glycyrrhizae, Bulbus Lilii, Fructus Crataegi.Wherein Radix Ginseng is a main component, its sweet temperature strongly invigorating primordial QI, spleen invigorating lung benefiting; Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying, as auxiliary element, Poria is sweet light, the eliminating dampness by diuresis spleen invigorating, Radix Glycyrrhizae is in harmonious proportion hundred medicines, adds Radix Astragali QI invigorating again with the ginseng QI invigorating of helping others, and Semen Coicis eliminating dampness by diuresis spleen invigorating is to help the effect of the Rhizoma Atractylodis Macrocephalae, Poria, the Ganoderma QI invigorating, the Lentinus Edodes QI invigorating and in, the lung moistening of Bulbus Lilii lung benefiting, the relieving dyspepsia of Fructus Crataegi removing food stagnancy.All medicines share, and play strongly invigorating primordial QI, spleen invigorating eliminating dampness by diuresis altogether, the effect of human body immunity improving power.
According to pharmacological testing, Radix Ginseng has two-ways regulation central nervous system, resisting fatigue, antireflecting effect, the human endocrine of adjustment is also arranged, regulate organism metabolism, enhancing human body immunity power, particularly strengthen cellular immune function, promote leukocyte to generate anti-allergic effects and antidiuretic activity.The Rhizoma Atractylodis Macrocephalae can suppress chemicotherapy dialogue cell inhibiting.The Radix Astragali can promote the humoral immunization and the cellular immunity of body.Ganoderma also can enhancing body cellular immunization and humoral immune function.And pharmacological testing proves that Radix Ginseng, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Semen Coicis, Bulbus Lilii, Ganoderma, Fructus Crataegi, Lentinus Edodes, Radix Glycyrrhizae have certain inhibitory action to animal experiment tumor (different tumors).As Radix Ginseng mice S180 and adenocarcinoma 755 there is inhibitory action.Rhizoma Atractylodis Macrocephalae volatile oil has the inhibition killing action to the S180 ehrlich carcinoma.Poria can significantly increase the inhibition effect of cyclophosphamide to tumor.Fructus Crataegi and Semen Coicis prescription have remarkable inhibitory action to the mice ehrlich ascites cell, and Monosodium glycyrrhetin and derivant thereof have inhibitory action to mice ehrlich carcinoma and sarcoma.Glycyrrhizin can suppress the yoshida sarcoma of hypodermic type.Glycyrrhizins etc. change rat ascites hepatocarcinoma and ehrlich ascites cell form.
In one embodiment of the invention, health product of the present invention can be made by the raw material of following consumption: Radix Ginseng 1-2%, Radix Astragali 15-20%, Rhizoma Atractylodis Macrocephalae 5-10%, Poria 5-10%, Semen Coicis 15-20%, Bulbus Lilii 3-8%, Ganoderma 5-10%, Fructus Crataegi 3-8%, Lentinus Edodes 5-10% and Radix Glycyrrhizae 5-10%.
In a preferred embodiment of the invention, health product of the present invention are preferably made by following raw materials according: Radix Ginseng 1.2%, the Radix Astragali 19.4%, the Rhizoma Atractylodis Macrocephalae 9.6%, Poria 9.6%, Semen Coicis 19.4%, Bulbus Lilii 6%, Ganoderma 9.6%, Fructus Crataegi 6%, Lentinus Edodes 9.6% and Radix Glycyrrhizae 9.6%.
The routine techniques that health product of the present invention can adopt above-mentioned raw materials and/or adjuvant commonly used pharmaceutically pharmaceutical field is prepared into different dosage forms such as capsule, electuary, tablet, oral liquid with it; Perhaps above-mentioned raw materials is added in the common food as cookies, bread, beverage etc. as additive.
The effective ingredient of health product of the present invention can adopt the following step to make:
A) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is condensed into extractum;
B) Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng powder are broken into fine powder, make the effective ingredient of health product of the present invention with above-mentioned extractum mixing.
The effective ingredient of health product of the present invention also can adopt the following step to make:
Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is condensed into the effective ingredient that extractum is made health product of the present invention.
The effective ingredient of health product of the present invention can adopt the following step to make again: Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, with the alcohol reflux of 60-95%, reclaim ethanol and obtain the effective ingredient that concentrate is health product of the present invention.
Preferred health product of the present invention are the capsules that adopt the following step to make:
A) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali and Fructus Crataegi powder are broken into coarse powder, steeped 10 minutes, boiled 30 minutes, filter 2 times with 25 ℃ of water loggings, merging filtrate, filtrate refilters after clarification, and 90 ℃ are condensed into extractum;
B) Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng powder are broken into fine powder and cross 80 mesh sieves, and granulate behind the above-mentioned extractum mixing;
C) wet grain was in 90 ℃ of oven dry 6 hours, and sterilization is made dry granular, filled capsules.
Preferred health product of the present invention are the oral liquids that adopt the following step to make: Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, be soaked in water, boiled 30-60 minute, filter, filtrate is condensed into extractum, makes oral liquid adding sweeting agents such as distilled water and Mel in the extractum.
Preferred health product of the present invention are to adopt the following step to make tablet: Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, alcohol reflux with 60-95%, reclaim ethanol and obtain concentrate, excipient that gained concentrate and preparation tablet is commonly used such as starch etc. are made wet granular, tabletting.
Health product of the present invention are to adopt following method to make cookies:
A) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is concentrated;
B) make cookies in the concentrated solution adding cookies raw material with the above-mentioned steps preparation.
Health product of the present invention have QI invigorating, spleen invigorating, eliminating dampness by diuresis, adjusting body's immunity, are a kind of ideal auxiliary health product or the food of tumor patient.Health product of the present invention can be taken for a long time and not have toxic and side effects, thereby the various treatments that the cooperation cancer patient accepts are to improve curative effect.
Concrete embodiment
Below, further set forth the beneficial effect of health product of the present invention by test.These tests comprise toxicity, pharmacodynamics test and the quality testing evaluation etc. of food of the present invention.
Embodiment 1:The capsular preparation of the present invention
A) according to following consumption raw materials weighing: Radix Ginseng 100g, Radix Astragali 1600g, Rhizoma Atractylodis Macrocephalae 800g, Poria 800g, Semen Coicis 1600g, Bulbus Lilii 500g, Ganoderma 800g, Fructus Crataegi 500g, Lentinus Edodes 800g and Radix Glycyrrhizae 800g;
B) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali and Fructus Crataegi powder are broken into coarse powder, steeped 10 minutes, boiled 30 minutes, filter 2 times with 25 ℃ of water loggings, merging filtrate, filtrate refilters after clarification, and 90 ℃ are condensed into extractum;
C) Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng powder are broken into fine powder and cross 80 mesh sieves, and granulate behind the above-mentioned extractum mixing;
D) wet grain was in 90 ℃ of oven dry 6 hours, and sterilization is made dry granular, filled capsules.
Embodiment 2:The preparation of tablet of the present invention
Take by weighing Radix Ginseng 100g, Radix Astragali 2000g, Rhizoma Atractylodis Macrocephalae 500g, Poria 500g, Semen Coicis 1500g, Bulbus Lilii 300g, Ganoderma 500g, Fructus Crataegi 400g, Lentinus Edodes 500g and Radix Glycyrrhizae 500g; Be ground into coarse powder, the alcohol reflux with 70% reclaims ethanol and obtains concentrate, and excipient that gained concentrate and preparation tablet is commonly used such as starch etc. are made wet granular, tabletting.
Embodiment 3:The preparation of electuary of the present invention:
A) take by weighing Radix Ginseng 200g, Radix Astragali 1500g, Rhizoma Atractylodis Macrocephalae 500g, Poria 500g, Semen Coicis 1500g, Bulbus Lilii 300g, Ganoderma 1000g, Fructus Crataegi 800g, Lentinus Edodes 1000g and Radix Glycyrrhizae 1000g;
B) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali and Fructus Crataegi powder are broken into coarse powder, steeped 10 minutes, boiled 30 minutes, filter 2 times with 25 ℃ of water loggings, merging filtrate, filtrate refilters after clarification, and 90 ℃ are condensed into extractum;
C) Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng powder are broken into fine powder and cross 80 mesh sieves, and granulate behind the above-mentioned extractum mixing;
D) with the particle drying of above-mentioned steps preparation, pack.
Embodiment 4:The preparation of oral liquid of the present invention
Take by weighing Radix Ginseng 150g, Radix Astragali 1600g, Rhizoma Atractylodis Macrocephalae 700g, Poria 700g, Semen Coicis 1600g, Bulbus Lilii 600g, Ganoderma 700g, Fructus Crataegi 500g, Lentinus Edodes 700g and Radix Glycyrrhizae 700g; Be ground into coarse powder, be soaked in water, boiled 30-60 minute, filter, filtrate is condensed into extractum, make oral liquid adding sweeting agents such as distilled water and Mel in the extractum.
Embodiment 5:The preparation of cookies of the present invention
A) take by weighing Radix Ginseng 20g, Radix Astragali 200g, Rhizoma Atractylodis Macrocephalae 100g, Poria 70g, Semen Coicis 160g, Bulbus Lilii 60g, Ganoderma 70g, Fructus Crataegi 80g, Lentinus Edodes 70g and Radix Glycyrrhizae 70g;
B) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is concentrated;
C) make cookies in the concentrated solution adding cookies raw material with the above-mentioned steps preparation.
Experimental example 1:The safety toxicological test of health product of the present invention
1. material and method:
Sample: the effective ingredient of health product of the present invention
Experimental animal: select Sanitation and Anti-epidemic Station, Fujian Prov. for use, the SD mice that the healthy Kunming mouse of animal field breeding and experimental animal center, Chinese Academy of Sciences Shanghai provide.
2. choose healthy Kunming mouse, each 20 of male and female, body weight 18-22g is divided into two groups, and male and female half and half take by weighing sample 5.0g and are dissolved in an amount of distilled water, and supersonic oscillations 30 minutes are molten to 15ml, make the sample suspension, are reference substance with the distilled water.Sample sets and matched group all give the sample suspension respectively by the 0.03ml/g body weight and distilled water is irritated stomach, observes for 2 weeks.Record poisoning manifestations and death condition.
3. the result shows: the both sexes mice does not see poisoning all and does not have death.Acute toxicity is 10g/kg.
Experimental example 2Mutagenicity test
1.Ames test; Adopt satisfactory mouse typhus Salmonella histidine defect type A97, TA98, TA100 and TA102 four strain test strains to test.Adopt the even oar of the inductive rats'liver of Polychlorinated biphenyls to make external metabolism activation system.The pasteurization degerming is used in the preparation of animal subject adding distil water.According to the determination of acute toxicity result, 5mg/IIII, 2.5mg/IIII, 1.25mg/IIII, 0.63mg/IIII, 0.32mg/IIII, five dosage groups are established in test, establish simultaneously from beaming back the change group, positive controls and S9 mixing matched group were cultivated 48 hours at 37 ℃, counted per four times and became clump count.If animal subject return to become clump count increase surpass from beam back become clump count more than 2 times and have dose response, be decided to be the positive.The result shows: each dosage group of health product of the present invention there is no the positive.There is not dose-response relationship yet.Explanation does not have inducing action to TA97, TA98, TA100 and TA102 four strain test organismss.
2. bone marrow cells in mice polychromatic erythrocyte micronucleus test: adopted 24 hours at interval, twice per os irritated stomach and tested.With 50 of body weight 25-30g healthy mices, be divided into 5 groups at random by body weight, every group 10, male and female half and half are with the positive contrast of cyclophosphamide of 100mg/kg body weight dosage, the negative contrast of distilled water, the animal subject adding distil water is made into three dosage groups, be respectively 1.66g/kg, 0.66g/kg, 0.33g/kg body weight, pressed the 0.02ml/g body weight 24 hours at interval, twice in continuous irrigation stomach.Last is irritated behind the stomach and the dislocation of animal subject cervical vertebra to be put to death animal in 6 hours.Get the marrow of thymus, dilute smear with calf serum, through formaldehyde fixed, Giemasa dyeing.Under optical microscope, observe.Every zoometer is than 1000 polychromatic erythrocytes, and microkernel incidence is asked 95% fiducial limit to contain microgranule PEC permillage by the Poisson distribution at random.The result shows: the micronuclear rates of each dosage group of health product of the present invention is all in this test reality in normal range.There is not significance (P＞0.05) with the negative control group comparing difference.And the cyclophosphamide positive controls relatively is highly significant (P＜0.01).Point out health product of the present invention not have the mouse bone marrow cells of bringing out PCE micronucleus formation effect.
3. mouse sperm distortion test: with 30 of body weight 30-35g sexual maturity male mices, be divided into 5 groups at random, cyclophosphamide abdominal part with the 30mg/kg body weight is injected positive contrast, the negative matched group of distilled water, tried the thing adding distil water and be made into 3 dosage groups, be respectively 1.25g/kg, 2.5g/kg, 5g/kg body weight, irritated the stomach one-time continuous every day 5 days.Last was irritated behind the stomach 30 days, put to death 5 animals, got the film-making of bilateral tail of epididymis, dyeing, microscopic examination sperm distortion incidence rate for every group.Health product of the present invention do not take place obviously to change to the mouse sperm deformity incidence rate, and each dosage group mouse sperm deformity rate of animal subject is all in this test chamber in normal range.There is not significance (P＞0.05) with the negative control group comparing difference.And the difference of cyclophosphamide positive controls and negative control group has highly significant (P＜0.01).Point out health product of the present invention that mouse sperm is not produced the distortion effect.
4. 30 days feeding trials of rat: the female 66.83+2.82g of rat, male 66.38+4.97g is divided into 4 groups at random by body weight, and 20 every group, male and female half and half.Test reception test animal per is 50,100,200 times of month recommended dose 6.0g only, establish three dosage groups and be 5.0,10.0, the 20.0g/kg body weight.Other establishes feminine gender and blank group.Feedstuff is with the weight of animals 10% conversion, and every preparation sample, by 3 dosage sample is evenly admixed in the feedstuff, feeds.Ad lib drinking-water.Duration of test is observed zoomorphism, weighs in the record feed consumption weekly.Feed after 30 days, routine blood test is made in blood sampling and biochemical indicator is measured, and the execution animal is got liver,kidney,spleen, stomach is done the pathology inspection.Biochemical indicator carries out with the reagent that Chinese-foreign joint Shanghai Long March Kang Ren medical science company limited provides.Hemoglobin dilution colorimetric method for determining, the GPT reitman-frankel method, BUN measures with two hexanoyl monoxime methods, and total protein is measured with biuret method, and albumin is measured with the green method of Australia's cresol.
The result shows: the animal gross morphology, the rat hair matter gloss of 3 dosage groups of health product of the present invention, mode of appearance and negative control group be indistinction relatively, does not also have the phenomena of mortality.The growth of body weight and efficiency of feed utilization there are no significant difference (P＞0.05).Hemoglobin content erythrocyte, leukocyte powder and leukocyte differential count and negative control group relatively there are no significant difference (P＞0.05).Each animal subject group liver body ratio, kidney body ratio, spleen body are than comparing there was no significant difference (P＞0.05) with negative control group.Liver,kidney,spleen, gastric tissue are learned inspection and are not seen the specificity pathological change.
5. rat tertogenicity test: select the ripe male and female Mus of health to carry out copulation, find negative morning every day, be decided to be the 0th day that this Mus is become pregnant by 1: 1.The Mus of will becoming pregnant is divided into 5 groups at random, be respectively three dosage groups of sample (2.5g/kg, 5g/kg, 10g/kg), positive controls (APC250mg/kg body weight) and negative control group (distilled water) at 7-16 days that become pregnant, every day, per os was tried thing, totally 20 days.Pregnant Mus is put to death.Laparotomy inspection absorbs tire number, stillborn fetus number, the tire number of living.Survey tire Mus alive height, body weight are used the alizarin red colouration with double several Mus, check the skeleton situation, and single tire drops into the liquid-solid fixed 5 heaven-made internal organs inspections of Bouins.
The result shows: health product of the present invention make the increase of pregnant Mus body weight be slightly less than the blank group.Low dose group tire rate alive is lower than the blank group.Average tire is counted no abnormality seen.Pregnant Os Mus bone is not seen teratogenesis.Tire Mus internal organs are not seen teratogenesis yet.
Experimental example 3:Health product of the present invention suppress the tumor test
Animal and feedstuff: Kunming mouse, standing feedstuff and BACB/C special feed provide (the animal quality certification number: medical science word 01-3001 number) by experimental animal institute of Chinese Academy of Sciences breeding field.The BACB/C mice provides (the animal quality certification number: No. 081, capital moving pipe matter word) by Nat'l Pharmaceutical ﹠ Biological Products Control Institute experimental animal center.
Material and reagent: S180 and H22 cell strain are all available from Chinese medicine institute institute of materia medica.Chicken red blood cell picks up from male and healthy Hangzhoupro chicken.The Yac-1 cell is available from five of Military Medical Science Institutes, and 1640 culture medium are available from U.S. GIBCO company, and NP-40 is a magnificent company product, and CDH substrate liquid and other reagent are domestic reagent (analytical pure).
The animal transplanting tumor test
A.180 cell strain test: male mice in kunming, body weight 18-22g is divided into 4 groups of normal control group (NC), high dose (HD), middle dosage (MD) and low dosages (CD), 12 every group at random.Health product of the present invention are diluted with dissolved in distilled water, irritate stomach (3.0g, 1.0g, 0.33g/kg body weight, 30,10 and 3.3 times of suitable human oral dosage respectively), the NC group is 0.4ml/20g simultaneously with distilled water.Irritated stomach the 13rd day, and under aseptic condition, continued to give animal subject in inoculation S180 tumor cell (5 * 106 cell/0.2ml/ only) inoculation back down in the right side axillary fossa.After 11 days, mice is put to death in the cervical vertebra dislocation, takes out the tumor body and weighs.Positive findings appears in The data one factor analysis of variance statistics, the requirement of instrument program, by above-mentioned test method once with 12 male mice repeated trials.The result shows: twice repeated trials shows that the tumor weight average of each dosage mice is lower than each dosage group of contrast, and certain dose-response relationship is arranged between group.High dose group and matched group comparing difference have significance (P＜0.05).High dose group presses down tumor greater than 30%.Its animal subject dosage group body weight difference of comparing with matched group does not have significance (P＞0.05).
B.H-22 cell strain test: male mice in kunming body weight 18-22g.Be divided into 4 groups of normal group (NC), high dose (HD), middle dosage (MD) and low dosages (CD) at random, 12 every group.Health product of the present invention are diluted with dissolved in distilled water, irritate stomach (3.0g, 1.0g, 0.33g/kg body weight, 30,10 and 3.3 times of suitable human oral dosage respectively), the NC group is irritated stomach with distilled water simultaneously, is 0.4ml/20g.Irritated stomach the 13rd day, and under aseptic condition, continued to give animal subject in inoculation H-22 tumor cell (5 * 106 cell/0.2ml/ only) inoculation back down in the right side axillary fossa.After 11 days, mice is put to death in the cervical vertebra dislocation, takes out the tumor body and weighs.Positive findings appears in The data one factor analysis of variance statistics, the requirement of instrument program, by above-mentioned test method once with 12 male mice repeated trials.
The result shows: twice repeated trials shows that the tumor weight average of each dosage mice is lower than each dosage group of contrast, and certain dose-response relationship is arranged.High, middle dosage group and matched group comparing difference have significance (P＜0.05).High dose group presses down tumor greater than 30%.But small dose group then difference does not have significance (P＞0.05).
Test example 4:The immunologic function test
Female BACB/C mice body weight 18-22g about six ages in week, experimental animal are divided into 4 groups of normal group (NC), high dose (HD), middle dosage (MD) and low dosages (CD), 10 every group at random.Health product of the present invention are irritated stomach, and sample treatment is tested with S180.High, medium and low dosage is respectively 3.0g, 1.0g, 0.33g/kg (the phagocytic activity test is 0.30g/kg), and the NC group is irritated stomach with distilled water simultaneously, and irritating the stomach amount is 0.4ml/20g.Continue to irritate stomach and kill after 20 days, carry out peritoneal macrophage and engulf the chicken red blood cell test, and measure the test of NKT (NK) cellularity with lactic acid dehydrogenase (CDH) method.The result shows that each dosage group phagocytic index and matched group more all have significant difference (P＜0.05).The NK activity (stomach) of high dose group is significantly higher than matched group (P＜0.05).
Claims (10)
1. a cancer patient uses health product, it is characterized in that its effective ingredient can be made by following raw materials according: Radix Ginseng 1-2%, Radix Astragali 15-20%, Rhizoma Atractylodis Macrocephalae 5-10%, Poria 5-10%, Semen Coicis 15-20%, Bulbus Lilii 3-8%, Ganoderma 5-10%, Fructus Crataegi 3-8%, Lentinus Edodes 5-10% and Radix Glycyrrhizae 5-10%.
2. use health product according to the described cancer patient of claim 1, wherein prepare raw materials of effective components and consumption thereof and be: Radix Ginseng 1.2%, the Radix Astragali 19.4%, the Rhizoma Atractylodis Macrocephalae 9.6%, Poria 9.6%, Semen Coicis 19.4%, Bulbus Lilii 6%, Ganoderma 9.6%, Fructus Crataegi 6%, Lentinus Edodes 9.6% and Radix Glycyrrhizae 9.6%.
3. use health product according to the described cancer patient of claim 2, it is capsule, electuary, tablet, oral liquid, cookies or drink form.
4. the preparation method of any one described health product among the claim 1-3, it comprises the following steps:
A) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is condensed into extractum;
B) Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng powder are broken into fine powder, make effective ingredient with above-mentioned extractum mixing.
5. in accordance with the method for claim 4, it also comprises the following steps:
A) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali and Fructus Crataegi powder are broken into coarse powder, steeped 10 minutes, boiled 30 minutes, filter 2 times with 25 ℃ of water loggings, merging filtrate, filtrate refilters after clarification, and 90 ℃ are condensed into extractum;
B) Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng powder are broken into fine powder and cross 80 mesh sieves, and granulate behind the above-mentioned extractum mixing;
C) wet grain was in 90 ℃ of oven dry 6 hours, and sterilization is made dry granular, filled capsules.
6. the preparation method of any one described health product among the claim 1-3, it comprises the following steps:
Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is condensed into extractum makes effective ingredient.
7. according to the described preparation method of claim 6, it comprises the following steps:
Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, be soaked in water, boiled 30-60 minute, filter, filtrate is condensed into extractum, makes oral liquid adding sweeting agents such as distilled water and Mel in the extractum.
8. according to the described preparation method of claim 6, it comprises the following steps:
A) Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, are soaked in water, boiled 30-60 minute, filter, filtrate is concentrated;
B) make cookies in the concentrated solution adding cookies raw material with the above-mentioned steps preparation.
9. the preparation method of any one described health product among the claim 1-3, it comprises the following steps:
Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, and with the alcohol reflux of 60-95%, recovery ethanol obtains concentrate and makes effective ingredient.
10. in accordance with the method for claim 9, it comprises the following steps:
Semen Coicis, the Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, the Radix Astragali, Ganoderma, Lentinus Edodes, Poria, Bulbus Lilii, Radix Ginseng and Fructus Crataegi powder are broken into coarse powder, alcohol reflux with 70%, reclaim ethanol and obtain concentrate, excipient that gained concentrate and preparation tablet is commonly used such as starch etc. are made wet granular, tabletting.
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| CNB031461883A CN1225209C (en) | 2003-07-28 | 2003-07-28 | Health food for cancer patient and preparing method thereof |
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| CN109662250A (en) * | 2019-01-18 | 2019-04-23 | 湖南泽迈生物科技有限公司 | A kind of health care product and formula preparation method with enhancing immune function |
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