CN1466455A - 用于鼻内给药的芬太尼组合物 - Google Patents
用于鼻内给药的芬太尼组合物 Download PDFInfo
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- CN1466455A CN1466455A CNA018161634A CN01816163A CN1466455A CN 1466455 A CN1466455 A CN 1466455A CN A018161634 A CNA018161634 A CN A018161634A CN 01816163 A CN01816163 A CN 01816163A CN 1466455 A CN1466455 A CN 1466455A
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- pain
- fentanyl
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Abstract
Description
范围 | 制剂I | 制剂II | 制剂III |
F(%) | 45-80 | 53-80 | 43-80 |
tmax(分) | 2-5 | 2-5 | 2-5 |
筛选/包含日 | 第一次手术日 | 第一次对照观察 | 第二次手术日 | 第二次对照观察 | |
被告知同意 | × | ||||
包含/排除的标准 | × | × | × | × | × |
体格检查 | × | ||||
既往和伴发的疾病 | × | × | × | × | × |
用于筛选药物滥用的尿液样品 | × | × | |||
用于筛选妊娠的尿液样品 | × | × | |||
用于药动学分析的血液样品 | × | × | |||
疼痛数据 | × | × | |||
氧饱和 | × | × | |||
耐受性 | × | × | |||
副作用 | × | × |
给药后的时间/分 | 血液样品 | 疼痛强度 | 耐受性 | 氧饱和 |
0 | × | × | × | × |
1 | × | |||
3 | × | |||
5 | × | |||
7 | × | |||
9 | × | |||
12 | × | |||
15 | × | × | × | × |
25 | × | |||
30 | × | × | × | |
40 | × | |||
45 | × | × | × | |
60 | × | × | × | × |
75 | × | × | × | |
90 | × | × | × | × |
105 | × | × | × | |
120 | × | × | × | × |
150 | × | × | × | |
180 | × | × | × | × |
210 | × | × | × | |
240 | × | × | × |
剂量组 | 鼻内时期*1.剂量 | 2.剂量 | 静脉内时期1.剂量 | 2.剂量 |
75μg | 芬太尼鼻内安慰剂静脉内 | 安慰剂鼻内安慰剂静脉内 | 芬太尼静脉内安慰剂鼻内 | 安慰剂静脉内安慰剂鼻内 |
100μg | 芬太尼鼻内安慰剂静脉内 | 安慰剂鼻内安慰剂静脉内 | 芬太尼静脉内安慰剂鼻内 | 安慰剂静脉内安慰剂鼻内 |
150μg | 芬太尼鼻内安慰剂静脉内 | 安慰剂鼻内安慰剂静脉内 | 芬太尼静脉内安慰剂鼻内 | 安慰剂静脉内安慰剂鼻内 |
200μg | 芬太尼鼻内安慰剂静脉内 | 安慰剂鼻内安慰剂静脉内 | 芬太尼静脉内安慰剂鼻内 | 安慰剂静脉内安慰剂鼻内 |
剂量组 | 时间“0”剂量 | 时间“5分钟”剂量 | ||
1.安瓿 | 2.安瓿 | 1.安瓿 | 2.安瓿 | |
75μg | Haldid | 无菌水 | 无菌水 | 无菌水 |
100μg | Haldid | Haldid | 无菌水 | 无菌水 |
150μg | Haldid | 无菌水 | Haldid | 无菌水 |
200μg | Haldid | Haldid | Haldid | Haldid |
Claims (82)
Applications Claiming Priority (2)
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DKPA200001154 | 2000-07-31 | ||
DKPA200001154 | 2000-07-31 |
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CNA2007101539372A Division CN101181241A (zh) | 2000-07-31 | 2001-07-31 | 用于鼻内给药的芬太尼组合物 |
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CN1466455A true CN1466455A (zh) | 2004-01-07 |
CN100346788C CN100346788C (zh) | 2007-11-07 |
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CNB018161634A Expired - Lifetime CN100346788C (zh) | 2000-07-31 | 2001-07-31 | 用于鼻内给药的芬太尼组合物 |
CNA2007101539372A Pending CN101181241A (zh) | 2000-07-31 | 2001-07-31 | 用于鼻内给药的芬太尼组合物 |
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Country Status (24)
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US (3) | US8017627B2 (zh) |
EP (3) | EP2255806A3 (zh) |
JP (2) | JP4898073B2 (zh) |
KR (2) | KR20080053423A (zh) |
CN (2) | CN100346788C (zh) |
AT (1) | ATE388705T1 (zh) |
AU (2) | AU2001281746C1 (zh) |
CA (1) | CA2417727C (zh) |
CY (2) | CY1107405T1 (zh) |
DE (2) | DE20122843U1 (zh) |
DK (2) | DK1642578T3 (zh) |
EA (1) | EA006384B1 (zh) |
EE (1) | EE05420B1 (zh) |
ES (2) | ES2427976T5 (zh) |
HK (1) | HK1089106A1 (zh) |
IL (2) | IL154041A0 (zh) |
IS (1) | IS2803B (zh) |
NO (2) | NO330565B1 (zh) |
NZ (1) | NZ524396A (zh) |
PL (1) | PL207845B1 (zh) |
PT (2) | PT1642578E (zh) |
SI (2) | SI1642578T2 (zh) |
UA (2) | UA77398C2 (zh) |
WO (1) | WO2002009707A1 (zh) |
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