CN1429571A - Notoginseng pain relieving plaster and its preparation method - Google Patents
Notoginseng pain relieving plaster and its preparation method Download PDFInfo
- Publication number
- CN1429571A CN1429571A CN 01131662 CN01131662A CN1429571A CN 1429571 A CN1429571 A CN 1429571A CN 01131662 CN01131662 CN 01131662 CN 01131662 A CN01131662 A CN 01131662A CN 1429571 A CN1429571 A CN 1429571A
- Authority
- CN
- China
- Prior art keywords
- radix
- notoginseng
- pain relieving
- myrrha
- olibanum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000003143 Panax notoginseng Nutrition 0.000 title claims abstract description 55
- 241000180649 Panax notoginseng Species 0.000 title claims abstract description 55
- 239000011505 plaster Substances 0.000 title claims abstract description 37
- 208000002193 Pain Diseases 0.000 title claims description 60
- 230000036407 pain Effects 0.000 title claims description 60
- 238000002360 preparation method Methods 0.000 title claims description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 11
- 229920001971 elastomer Polymers 0.000 claims abstract description 9
- 239000011248 coating agent Substances 0.000 claims abstract description 7
- 238000000576 coating method Methods 0.000 claims abstract description 7
- 238000005520 cutting process Methods 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims abstract description 4
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000000843 powder Substances 0.000 claims description 24
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 23
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 18
- 241000717739 Boswellia sacra Species 0.000 claims description 15
- 239000004863 Frankincense Substances 0.000 claims description 15
- 241001057584 Myrrha Species 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 15
- 239000006071 cream Substances 0.000 claims description 14
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 9
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 9
- 241000628997 Flos Species 0.000 claims description 9
- 241000195474 Sargassum Species 0.000 claims description 9
- 229940025250 camphora Drugs 0.000 claims description 9
- 239000010238 camphora Substances 0.000 claims description 9
- 229960001047 methyl salicylate Drugs 0.000 claims description 9
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- RSWGJHLUYNHPMX-ONCXSQPRSA-N abietic acid Chemical compound C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C(O)=O RSWGJHLUYNHPMX-ONCXSQPRSA-N 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 6
- 238000005325 percolation Methods 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 5
- 238000010992 reflux Methods 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 208000026137 Soft tissue injury Diseases 0.000 abstract description 7
- 201000003068 rheumatic fever Diseases 0.000 abstract description 6
- 230000000146 antalgic effect Effects 0.000 abstract description 2
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 abstract 1
- 241001671653 Aconitum carmichaelii Species 0.000 abstract 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 22
- 208000024891 symptom Diseases 0.000 description 16
- 230000008961 swelling Effects 0.000 description 14
- 208000014674 injury Diseases 0.000 description 13
- 208000006820 Arthralgia Diseases 0.000 description 10
- 208000027418 Wounds and injury Diseases 0.000 description 9
- 210000003414 extremity Anatomy 0.000 description 9
- 230000008733 trauma Effects 0.000 description 9
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 7
- 206010034464 Periarthritis Diseases 0.000 description 7
- 206010052428 Wound Diseases 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 230000000472 traumatic effect Effects 0.000 description 6
- 208000025978 Athletic injury Diseases 0.000 description 5
- 208000025747 Rheumatic disease Diseases 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 230000004064 dysfunction Effects 0.000 description 5
- 230000000552 rheumatic effect Effects 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 206010014080 Ecchymosis Diseases 0.000 description 3
- 208000029549 Muscle injury Diseases 0.000 description 3
- 208000000112 Myalgia Diseases 0.000 description 3
- 208000021945 Tendon injury Diseases 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000000988 bone and bone Anatomy 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000000835 fiber Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010024453 Ligament sprain Diseases 0.000 description 2
- 241000972155 Moschus Species 0.000 description 2
- 206010034568 Peripheral coldness Diseases 0.000 description 2
- 208000010040 Sprains and Strains Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- PBQVHWFDMNCCIH-KNJAVFAGSA-N (4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;n,n-dimethyl-1-phenothiazin-10-ylpropan-2-amine;n-(4-hydroxyphenyl)acetamide;phosphoric acid;hydrochloride Chemical compound Cl.OP(O)(O)=O.CC(=O)NC1=CC=C(O)C=C1.C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1.C([C@H]1C(N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC PBQVHWFDMNCCIH-KNJAVFAGSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- UFNDONGOJKNAES-UHFFFAOYSA-N Ginsenoside Rb1 Natural products CC(=CCCC(C)(OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CC(O)C45C)C UFNDONGOJKNAES-UHFFFAOYSA-N 0.000 description 1
- 206010020651 Hyperkinesia Diseases 0.000 description 1
- 208000000269 Hyperkinesis Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 241000283956 Manis Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010028391 Musculoskeletal Pain Diseases 0.000 description 1
- 208000028389 Nerve injury Diseases 0.000 description 1
- 208000007613 Shoulder Pain Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 241001330502 Stephania Species 0.000 description 1
- YURJSTAIMNSZAE-UHFFFAOYSA-N UNPD89172 Natural products C1CC(C2(CC(C3C(C)(C)C(O)CCC3(C)C2CC2O)OC3C(C(O)C(O)C(CO)O3)O)C)(C)C2C1C(C)(CCC=C(C)C)OC1OC(CO)C(O)C(O)C1O YURJSTAIMNSZAE-UHFFFAOYSA-N 0.000 description 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000009519 contusion Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000012850 discrimination method Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- GZYPWOGIYAIIPV-JBDTYSNRSA-N ginsenoside Rb1 Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)O[C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(CC[C@H]4C(C)(C)[C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)CC[C@]4(C)[C@H]3C[C@H]2O)C)(C)CC1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GZYPWOGIYAIIPV-JBDTYSNRSA-N 0.000 description 1
- TXEWRVNOAJOINC-UHFFFAOYSA-N ginsenoside Rb2 Natural products CC(=CCCC(OC1OC(COC2OCC(O)C(O)C2O)C(O)C(O)C1O)C3CCC4(C)C3C(O)CC5C6(C)CCC(OC7OC(CO)C(O)C(O)C7OC8OC(CO)C(O)C(O)C8O)C(C)(C)C6CCC45C)C TXEWRVNOAJOINC-UHFFFAOYSA-N 0.000 description 1
- YURJSTAIMNSZAE-HHNZYBFYSA-N ginsenoside Rg1 Chemical compound O([C@@](C)(CCC=C(C)C)[C@@H]1[C@@H]2[C@@]([C@@]3(C[C@@H]([C@H]4C(C)(C)[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]2O)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)C)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YURJSTAIMNSZAE-HHNZYBFYSA-N 0.000 description 1
- CBEHEBUBNAGGKC-UHFFFAOYSA-N ginsenoside Rg1 Natural products CC(=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C2CCC3(C)C2C(O)CC4C5(C)CCC(O)C(C)(C)C5CC(OC6OC(CO)C(O)C(O)C6O)C34C)C CBEHEBUBNAGGKC-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 230000008764 nerve damage Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 210000000323 shoulder joint Anatomy 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- CGFYHILWFSGVJS-UHFFFAOYSA-N silicic acid;trioxotungsten Chemical compound O[Si](O)(O)O.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1.O=[W]1(=O)O[W](=O)(=O)O[W](=O)(=O)O1 CGFYHILWFSGVJS-UHFFFAOYSA-N 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- KOECRLKKXSXCPB-UHFFFAOYSA-K triiodobismuthane Chemical compound I[Bi](I)I KOECRLKKXSXCPB-UHFFFAOYSA-K 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
An antalgic plaster for treating soft tissue injury, rheumatic arthritis and periomethritis is prepared from 28 raw materials including notoginseng, corydalis tuber, sichuan aconite root, radix zanthoxyli, etc. through breaking 21 of them, pulverizing 3 of them, preparing extract, adding others plus rubber and rosin for forming matrix, coating, cutting and covering.
Description
Technical field
The present invention relates to a kind of external-applied ointment and preparation method thereof, particularly the preparation method of notoginseng pain relieving plaster (having another name called Radix Notoginseng cream, Radix Notoginseng analgesia ointment, Radix Notoginseng ZHITONG GAO, Moschus notoginseng pain relieving plaster, Moschus Radix Notoginseng ZHITONG GAO, Radix Notoginseng panchrest plaster, Radix Notoginseng Dieda plaster for curing traumatic injury, Radix Notoginseng ache-reliving plaster etc.) and this notoginseng pain relieving plaster thereof.
Background technology
Human soft tissue injury, motherland's medical science all belongs to the muscle and tendon injury category, by the injured cause of disease, obvious trauma history person is arranged as spraining, dampening, and hindering back to consultation time is new wound in two weeks with interior person, is old trauma with the epigenesist; As do not have obvious trauma history, because of the local hyperkinesia of limbs, be overworked for a very long period into damage person's the strain that is.No matter new wound, old trauma or impairment caused by overstrain, the cardinal symptom of muscle and tendon injury is exactly a pain, swelling and dysfunction.Rheumatic arthralgia and scapulohumeral periarthritis also are human commonly encountered diseases and frequently-occurring diseases in addition.The medicine for external use of this disease of treatment mainly is a detumescence pain stop paste at present; as Chinese patent CN1191741A disclosed " a kind of osteopatia sprain plaster and preparation method thereof "; Chinese patent CN119172A disclosed " pain is pasted "; Chinese patent CN1042657A disclosed " a kind of preparation method of adhesive plaster for treating injury pain "; Chinese patent CN1060787A disclosed " reparation technology of red medicine plaster " and the applicant produce; the athletic injury cream of selling; these plaster exist source, medicine source difficulty; as Squama Manis; state guarantee animals such as Stephania cepharatha Hayata etc.; and the not high defective of slow curative effect, cure rate.
Summary of the invention
One of the object of the invention provides wide, the eutherapeutic notoginseng pain relieving plaster in source, a kind of medicine source, to solve the problems that existing antalgic ointment exists.
Two of the object of the invention provides the preparation method of above-mentioned notoginseng pain relieving plaster.
For achieving the above object, the technical solution adopted in the present invention is: notoginseng pain relieving plaster is characterized in that it is the unguentum of being made by following raw materials by weight proportions:
Radix Notoginseng 20-40 part Rhizoma Corydalis 9-15 part Radix Aconiti 30-60 part
Radix Zanthoxyli 20-30 part Radix Aconiti Kusnezoffii 30-60 part Herba Hyperici Sampsonii 30-60 part
Radix Aucklandiae 30-60 part Cortex Kalopanacis 30-60 part Cortex Cinnamomi 40-120 part
Caulis Aristolochiae Manshuriensis 20-60 part Fructus Capsici 40-90 part Radix Wikstroemae 15-60 part
Radix Stephaniae Tetrandrae 30-60 part Fructus Kochiae 15-60 part Lignum Sappan 30-60 part
Olibanum (system) 20-40 part Flos Carthami 30-60 part Myrrha (processed) 20-40 part
Radix Angelicae Sinensis 15-60 part Radix Dipsaci 30-60 part Radix Et Rhizoma Rhei 20-40 part
Herba Ephedrae 15-60 part Pericarpium Zanthoxyli 5-15 part Sargassum 5-15 part
Camphora 5-15 part Mentholum 15-30 part Borneolum Syntheticum 3-15 part
Methyl salicylate 15-30 part.
A kind of production method of above-mentioned each crude drug being made notoginseng pain relieving plaster of the present invention is: Radix Notoginseng, Olibanum (system), Myrrha (processed) are ground into fine powder; Rhizoma Corydalis, Radix Aconiti, Radix Zanthoxyli, Radix Aconiti Kusnezoffii, Herba Hyperici Sampsonii, the Radix Aucklandiae, Cortex Kalopanacis, Cortex Cinnamomi, Caulis Aristolochiae Manshuriensis, Fructus Capsici, Radix Wikstroemae, Radix Stephaniae Tetrandrae, the Fructus Kochiae, Lignum Sappan, Flos Carthami, Radix Angelicae Sinensis, Radix Dipsaci, Radix Et Rhizoma Rhei, Herba Ephedrae, Pericarpium Zanthoxyli, Sargassum powder are broken into coarse powder; According to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia nineteen ninety-five version), make solvent with 90% ethanol, flood after 7 days, slowly percolation to percolate near colourless till, the collection liquid of filtering, reclaim ethanol, be concentrated into extractum, add Radix Notoginseng, Olibanum (system), Myrrha (processed) fine powder and Camphora, Mentholum, Borneolum Syntheticum, methyl salicylate successively, gross weight by said medicine, other adds the doubly heavy substrate of being made by rubber, Colophonium of 3.7-4.0, stirs and makes coating, is coated with cream, cutting, the lid lining is cut into small pieces, promptly.
The another kind of production method of above-mentioned each crude drug being made notoginseng pain relieving plaster of the present invention is: Radix Notoginseng, Olibanum (system), Myrrha (processed) are ground into fine powder; Rhizoma Corydalis, Radix Aconiti, Radix Zanthoxyli, Radix Aconiti Kusnezoffii, Herba Hyperici Sampsonii, the Radix Aucklandiae, Cortex Kalopanacis, Cortex Cinnamomi, Caulis Aristolochiae Manshuriensis, Fructus Capsici, Radix Wikstroemae, Radix Stephaniae Tetrandrae, the Fructus Kochiae, Lignum Sappan, Flos Carthami, Radix Angelicae Sinensis, Radix Dipsaci, Radix Et Rhizoma Rhei, Herba Ephedrae, Pericarpium Zanthoxyli, Sargassum powder are broken into coarse powder; With the alcohol reflux of 85%-95% three times, each 1.5 hours, merge extractive liquid,, reclaim ethanol, being concentrated into relative density is the extractum of 1.16-1.21 (55-60 ℃ of heat is surveyed), adds Radix Notoginseng, Olibanum (system), Myrrha (processed) fine powder and Camphora, Mentholum, Borneolum Syntheticum, methyl salicylate successively, gross weight by said medicine, other adds the doubly heavy substrate of being made by rubber, Colophonium of 3.7-4.0, stirs and makes coating, is coated with cream, cutting, the lid lining is cut into small pieces, promptly.
Notoginseng pain relieving plaster of the present invention is light brown or brown lamellar rubber cream, gas fragrance.
The discrimination method of notoginseng pain relieving plaster of the present invention is:
(1), get 3 of notoginseng pain relieving plasters of the present invention and add strong ammonia solution 3ml, flooded 10 minutes, add chloroform 20ml, put in the water-bath reflux 30 minutes, and put coldly, add 5% hydrochloric acid solution 30ml, stir, placed 1 hour, divide and get the sour water layer, filter, filtrate is concentrated into about 2ml, splits in three test tubes, one pipe adds silico-tungstic acid test solution 2-3 and drips, and generates pale precipitation, and a pipe adds bismuth iodide test solution 2-3 and drips, generate salmon precipitation, a pipe adds test solution of mercuric potassium iodide and generates the yellow-white precipitation.
(2), get 5 of notoginseng pain relieving plasters of the present invention, water saturated n-butyl alcohol 50ml in addition, jolting 10 minutes was soaked 2 hours, filter, filtrate is in order to the saturated water washing of n-butyl alcohol 3 times, and each 25ml discards aqueous solution, n-butyl alcohol liquid is put evaporate to dryness in the water-bath, residue adds methanol 1ml, makes dissolving, as need testing solution; Other gets ginsenoside Rb1, Rg1 and arasaponin R1 reference substance.Add methanol and make the mixed solution that contains 1mg among every 1ml, in contrast product solution.Test according to thin layer chromatography (appendix VIB of Chinese Pharmacopoeia nineteen ninety-five version), draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, upper solution with n-butyl alcohol-glacial acetic acid-water (4: 1: 5) is developing solvent, launch, take out airing, spray is with 10% ethanol solution of sulfuric acid, put 105 ℃ dry by the fire to the speckle colour developing clear.In the test sample chromatograph, with the corresponding position of matched group chromatograph on, show the speckle of same color.
The mensuration of notoginseng pain relieving plaster paste containing amount of the present invention is measured according to the paste containing amount algoscopy (appendix IQ of Chinese Pharmacopoeia nineteen ninety-five version) under the rubber-emplastrum item, makes solvent with ether, every 100cm
2Should be no less than 1.7g.
Other everyly should meet every regulation relevant under the rubber agent item (appendix IQ of Chinese Pharmacopoeia nineteen ninety-five version) notoginseng pain relieving plaster of the present invention.
The detection method of notoginseng pain relieving plaster volatile ingredient of the present invention is: get notoginseng pain relieving plaster 35cm
2, to remove every lining, the accurate title, decided weight, put 105 ℃ of dryings 5/ hour, puts in the exsiccator and cooled off 30 minutes, and accurate title is fixed, reduces weight and should be no less than 4.0%.
Adopt the notoginseng pain relieving plaster of technical scheme preparation provided by the invention, have wide, low, the eutherapeutic advantage of product cost in source, medicine source, have the effect of activating blood circulation to dissipate blood stasis, subduing swelling and relieving pain, promoting the flow of QI in the collateral by warming the meridian, expelling wind and removing dampness.Treatment traumatic injury, rheumatic arthralgia, shoulder, arm, all kinds of soft tissue injurys of lumbago and skelalgia are had specially good effect, below are the clinical practice data of notoginseng pain relieving plaster treatment soft tissue injury of the present invention:
1, clinical data
Notoginseng pain relieving plaster group 30 examples, male's 11 examples wherein, women's 19 examples, the oldest person 84 years old, reckling 23 years old, the mean age is 46.8 years old, new wound 10 examples, old trauma 8 examples, 12 examples of straining.
Athletic injury cream group 30 examples, male's 13 examples wherein, women's 17 examples, the oldest person 72 years old, reckling 11 years old, the mean age is 41.8 years old, new wound 9 examples, old trauma 8 examples, 13 examples of straining.
2, object of observation standard
(1), the general soft tissue sprain among the outpatient, contusion or chronic strain patient.
(2), damage is new wound in two weeks with interior person; Two the week after or the chronic strain person be old wound.
(3), there are pain, tenderness, swelling in the damage part or livid purple ecchymosis is arranged.
(4), hindering limb or part can be with dysfunction and tractive pain.
3, observe the eliminating object
(1), eliminating suffers from fracture, dislocation; Blood vessel, nerve injury or tendon, ligament rapture and the non-traumatic pathological changes that swells and ache.
(2), there are dermatosis or skin injury in all parts, or to the cloth hypersensitivity person, or the anemia of pregnant woman all avoids usefulness.
(3), allly suffer from heavier internal injury or internal medicine disease, or physical weakness is repaired influential person to damaged tissue.
4, observational technique
Observed case by prescription on individual diagnosis precedence numbering, is adopted the odd or even number random packet again, and the single blind method of utilization is carried out the clinical control observation, is that observation group is a notoginseng pain relieving plaster with even number; Odd number is a matched group.Be athletic injury cream, both are 7 * 10cm by area, paste the injury with one of this cream, change dressings once in every 24-48 hour, and observed once in per three days, and keep the score, be weekly a course of treatment, observed for one to three week continuously.
5, observation item
Acute or chronic soft tissue injury, motherland's medical science all belongs to " muscle and tendon injury " category, its cardinal symptom is pain, swelling and dysfunction (seeing " traumatological department of TCM " the 5th version section teaching material 188 faces), clinical observation is by cardinal symptom pain, swelling and the handicapped 0-III group that is divided in various degree of new wound, old trauma or strain, press 0-3 respectively and divide score, the person was with score in 0.5 fen within 1 minute, full marks are 9 minutes, with this as damage index, again by the fractional percentage ratio of treatment back decline, as the foundation of evaluation curative effect.
6, score standard
(1), pain: be divided into level Four.
0 grade: no pain.
I level: mild pain: there is mild tenderness the part, hinders limb appearance activity pain when movable significantly, does not have spontaneous pain, and routine work and life are not had obviously influence.
II level: moderate pain: there is obvious tenderness in the traumatic part, the oxycinesia of living, and slight spontaneous pain is arranged, routine work and life there are certain influence.
III level: severe pain: there is the spontaneous severe pain of continuing in the traumatic part, and tenderness, and restriction limb activity influence routine work and life.
(2), swelling: be divided into level Four.
0 grade: no swelling.
I level: mild swelling: the part has swelling slightly, or ecchymosis is arranged, and bone mark is obvious.
II level: moderate swelling: local organization swelling is more obvious, and ecchymosis is arranged, and bone mark shoals.
III level: severe swelling: local organization swelling is obvious, and the skin anxiety is shinny, and bone mark disappears.
(3), dysfunction: be divided into level Four.
0 grade: no dysfunction.
The I level: slight obstacle: the traumatic part joint motion is limited slightly, and limb function is not had obvious influence.
II level: moderate obstacle: traumatic part joint motion part is limited, and limb function is had certain influence.
III level: severe obstacle: there is the manifest function obstacle in the traumatic part, and the joint active movement is also limited, or upper limb can not be prudent; Or lower limb can not be walked.
7, efficacy assessment standard
(1), complete more: the treatment back checks, more than three big symptoms amount to decline 91% above person before the proportions by subtraction treatment.
(2), produce effects: treatment back checks, more than three big symptoms amount to the preceding decline 70-90% person of proportions by subtraction treatment.
(3), take a turn for the better: the treatment back checks, more than three big symptoms amount to the preceding decline 36-69% person of proportions by subtraction treatment.
(4), invalid: treatment back checks, more than three big symptoms amount to decline 35% following person before the proportions by subtraction treatment.
8, therapeutic effect
(1), the notoginseng pain relieving plaster group: 5 examples more entirely, account for 16.7%, produce effects 18 examples account for 60%; 17 examples that take a turn for the better account for 56.7%; Invalid 0 example, total effective rate are 100%.
(2), athletic injury cream group: 1 example more entirely, account for 3.3%, produce effects 10 examples account for 33.3%; 17 examples that take a turn for the better account for 56.7%; Invalid 2 examples account for 6.7%, and total effective rate is 93.3%.
Two groups of curative effect contrast observings are had notable difference P＜0.01, and provable notoginseng pain relieving plaster treatment soft tissue injury is more effective than athletic injury cream.
In addition, notoginseng pain relieving plaster of the present invention is effective in cure to treatment rheumatic arthralgia and scapulohumeral periarthritis.Its clinical observation result is as follows:
1, the object of observation
1.1, rheumatic arthralgia (rheumatic arthralgia)
Diagnostic criteria is with reference to " the rheumatism four pains " standard in " up-to-date domestic and international disease treatment standard ".
(1), rheumatism it is attacked by the cold and evil history is arranged; (2), arthralgia, myalgia, limb fiber crops, chance cold symptoms increase the weight of; (3), joint movement function is limited; (4), erythrocyte sedimentation rate, anti-" O " routine blood test is normal.
1.2, scapulohumeral periarthritis
Diagnostic criteria is with reference to the 3rd edition 838 pages of Qiu Fazu chief editor " surgery " People's Health Publishers 1993.
(1), slow onset, do not have obvious trauma history; (2), the course of disease is long, shoulder pain increases the weight of gradually; (3), shoulder joint limitation of activity.
1.3, Chinese medical discrimination (reference source with 1.1)
The wind and cold wet type: (1), arthralgia, (2), myalgia, (3), limb fiber crops cold extremities, (4), part are heavy, (5), joint joint stuffiness, (6), body of the tongue are light red, Tai Bai or white greasy, (7), stringy pulse delay or moisten.
1.4, the object of observation gets rid of following several situations
(1), obvious trauma history is arranged; (2), acute rheumatic fever; (3), cloth hypersensitivity.
1.5, observe routine number
(1), rheumatic arthritis 15 examples
(2), scapulohumeral periarthritis 15 examples
2, medication and observational technique
2.1,30 examples all use notoginseng pain relieving plaster, paste the affected part, changed once in 24 hours.
2.2, be for 3 weeks the course of treatment.
2.3, observation item: clinical symptoms such as arthralgia.
3, efficacy evaluation: divide 4 grades, adopt 4 grades of scoring methods of primary symptom light and heavy degree, score-sheet is as follows:
4 grades of score-sheets of symptom
| ????+ | ????++ | ????+++ | ????++++ | |
| Arthralgia | Gently, idol has pain | Pain when movable | Pain during rest | Severe pain informal dress analgesic |
| Myalgia | Gently, idol has pain | Pain when movable | Pain during rest | Severe pain informal dress analgesic |
| Limb fiber crops cold extremities | Gently, idol has | Often have | The Chang Youxu insulation | Influence activity |
| Local heavy | Idol has sense of heaviness | Between often have | Often have | Influence activity |
| Joint stuffiness | Movable pain increases the weight of | Limitation of activity | Can not normal activity | For a long time can not normal activity |
| Bony crepitus | Idol has | Between often have | Often have | Often have obviously |
4, curative effect classification
(1), cure in the recent period, control the back symptom integral and reduce more than 91%;
(2), produce effects, control the back symptom integral and reduce more than the 70-90%;
(3), effectively, controlling the back symptom integral reduces more than the 36-69%;
(4), invalid, control the back symptom integral and reduce more than＜35%;
5, result
The clinical symptoms curative effect sees the following form
| The example number | Cure in the recent period | Produce effects | Effectively | Total effective rate (%) | Invalid | |
| Example % | Example % | Example % | Example % | |||
| Rheumatic arthritis | 15 | ?0????0 | 8???54 | 5????33 | ????87 | 2????13 |
| Scapulohumeral periarthritis | 15 | ?0????0 | 7???47 | 3????20 | ????67 | 5????33 |
| Add up to | 30 | 15??50 | 8????27 | ????77 | 7????23 |
The result shows that notoginseng pain relieving plaster of the present invention is 77% to rheumatic arthritis and scapulohumeral periarthritis total effective rate, and obvious effective rate reaches 50%, in the common symptom, to alleviate arthralgia for outstanding.
In sum, the present invention is with promoting blood circulation and stopping pain, and the Radix Notoginseng of promoting tissue regeneration by removing blood stasis is a principal agent, and compatibility Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Corydalis etc. have relaxing muscles and tendons and activating QI and blood in the collateral, and the effect of reducing swelling and alleviating pain has specially good effect to soft tissue injury, rheumatic arthritis and scapulohumeral periarthritis.
The specific embodiment
Notoginseng pain relieving plaster is the unguentum of making by following proportioning weighting raw materials:
Radix Notoginseng 25g Rhizoma Corydalis 10g Radix Aconiti 45g Radix Zanthoxyli 25g
Radix Aconiti Kusnezoffii 45g Herba Hyperici Sampsonii 45g Radix Aucklandiae 25g Cortex Kalopanacis 45g
Cortex Cinnamomi 80g Caulis Aristolochiae Manshuriensis 45g Fructus Capsici 65g Radix Wikstroemae 40g
Radix Stephaniae Tetrandrae 45g Fructus Kochiae 40g Lignum Sappan 45g Olibanum (system) 25g
Flos Carthami 45g Myrrha (processed) 25g Radix Angelicae Sinensis 40g Radix Dipsaci 45g
Radix Et Rhizoma Rhei 25g Herba Ephedrae 45g Pericarpium Zanthoxyli 10g Sargassum 10g
Camphora 10g Mentholum 20g Borneolum Syntheticum 9g methyl salicylate 20g.
Its production method can be as follows:
Radix Notoginseng, Olibanum (system), Myrrha (processed) are ground into fine powder; Rhizoma Corydalis, Radix Aconiti, Radix Zanthoxyli, Radix Aconiti Kusnezoffii, Herba Hyperici Sampsonii, the Radix Aucklandiae, Cortex Kalopanacis, Cortex Cinnamomi, Caulis Aristolochiae Manshuriensis, Fructus Capsici, Radix Wikstroemae, Radix Stephaniae Tetrandrae, the Fructus Kochiae, Lignum Sappan, Flos Carthami, Radix Angelicae Sinensis, Radix Dipsaci, Radix Et Rhizoma Rhei, Herba Ephedrae, Pericarpium Zanthoxyli, Sargassum powder are broken into coarse powder; According to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia nineteen ninety-five version), make solvent with 90% ethanol, flood after 7 days, slowly percolation to percolate near colourless till, the collection liquid of filtering, reclaim ethanol, be concentrated into extractum, add Radix Notoginseng, Olibanum (system), Myrrha (processed) fine powder and Camphora, Mentholum, Borneolum Syntheticum, methyl salicylate successively, gross weight by said medicine, other adds the doubly heavy substrate of being made by rubber, Colophonium of 3.7-4.0, stirs and makes coating, is coated with cream, cutting, the lid lining is cut into small pieces, promptly.
Its production method also can be as follows:
Radix Notoginseng, Olibanum (system), Myrrha (processed) are ground into fine powder; Rhizoma Corydalis, Radix Aconiti, Radix Zanthoxyli, Radix Aconiti Kusnezoffii, Herba Hyperici Sampsonii, the Radix Aucklandiae, Cortex Kalopanacis, Cortex Cinnamomi, Caulis Aristolochiae Manshuriensis, Fructus Capsici, Radix Wikstroemae, Radix Stephaniae Tetrandrae, the Fructus Kochiae, Lignum Sappan, Flos Carthami, Radix Angelicae Sinensis, Radix Dipsaci, Radix Et Rhizoma Rhei, Herba Ephedrae, Pericarpium Zanthoxyli, Sargassum powder are broken into coarse powder; With the alcohol reflux of 85%-95% three times, each 1.5 hours, merge extractive liquid,, reclaim ethanol, being concentrated into relative density is the extractum of 1.16-1.21 (55-60 ℃ of heat is surveyed), adds Radix Notoginseng, Olibanum (system), Myrrha (processed) fine powder and Camphora, Mentholum, Borneolum Syntheticum, methyl salicylate successively, gross weight by said medicine, other adds the doubly heavy substrate of being made by rubber, Colophonium of 3.7-4.0, stirs and makes coating, is coated with cream, cutting, the lid lining is cut into small pieces, promptly.
Claims (3)
1, notoginseng pain relieving plaster is characterized in that it is the unguentum of being made by following raw materials by weight proportions:
Radix Notoginseng 20-40 part Rhizoma Corydalis 9-15 part Radix Aconiti 30-60 part
Radix Zanthoxyli 20-30 part Radix Aconiti Kusnezoffii 30-60 part Herba Hyperici Sampsonii 30-60 part
Radix Aucklandiae 30-60 part Cortex Kalopanacis 30-60 part Cortex Cinnamomi 40-120 part
Caulis Aristolochiae Manshuriensis 20-60 part Fructus Capsici 40-90 part Radix Wikstroemae 15-60 part
Radix Stephaniae Tetrandrae 30-60 part Fructus Kochiae 15-60 part Lignum Sappan 30-60 part
Olibanum (system) 20-40 part Flos Carthami 30-60 part Myrrha (processed) 20-40 part
Radix Angelicae Sinensis 15-60 part Radix Dipsaci 30-60 part Radix Et Rhizoma Rhei 20-40 part
Herba Ephedrae 15-60 part Pericarpium Zanthoxyli 5-15 part Sargassum 5-15 part
Camphora 5-15 part Mentholum 15-30 part Borneolum Syntheticum 3-15 part
Methyl salicylate 15-30 part.
2, a kind of preparation method of notoginseng pain relieving plaster as claimed in claim 1 is characterized in that Radix Notoginseng, Olibanum (system), Myrrha (processed) are ground into fine powder; Rhizoma Corydalis, Radix Aconiti, Radix Zanthoxyli, Radix Aconiti Kusnezoffii, Herba Hyperici Sampsonii, the Radix Aucklandiae, Cortex Kalopanacis, Cortex Cinnamomi, Caulis Aristolochiae Manshuriensis, Fructus Capsici, Radix Wikstroemae, Radix Stephaniae Tetrandrae, the Fructus Kochiae, Lignum Sappan, Flos Carthami, Radix Angelicae Sinensis, Radix Dipsaci, Radix Et Rhizoma Rhei, Herba Ephedrae, Pericarpium Zanthoxyli, Sargassum powder are broken into coarse powder; According to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia nineteen ninety-five version), make solvent with 90% ethanol, flood after 7 days, slowly percolation to percolate near colourless till, the collection liquid of filtering, reclaim ethanol, be concentrated into extractum, add Radix Notoginseng, Olibanum (system), Myrrha (processed) fine powder and Camphora, Mentholum, Borneolum Syntheticum, methyl salicylate successively, gross weight by said medicine, other adds the doubly heavy substrate of being made by rubber, Colophonium of 3.7-4.0, stirs and makes coating, is coated with cream, cutting, the lid lining is cut into small pieces, promptly.
3, a kind of preparation method of notoginseng pain relieving plaster as claimed in claim 1 is characterized in that Radix Notoginseng, Olibanum (system), Myrrha (processed) are ground into fine powder; Rhizoma Corydalis, Radix Aconiti, Radix Zanthoxyli, Radix Aconiti Kusnezoffii, Herba Hyperici Sampsonii, the Radix Aucklandiae, Cortex Kalopanacis, Cortex Cinnamomi, Caulis Aristolochiae Manshuriensis, Fructus Capsici, Radix Wikstroemae, Radix Stephaniae Tetrandrae, the Fructus Kochiae, Lignum Sappan, Flos Carthami, Radix Angelicae Sinensis, Radix Dipsaci, Radix Et Rhizoma Rhei, Herba Ephedrae, Pericarpium Zanthoxyli, Sargassum powder are broken into coarse powder; With the alcohol reflux of 85%-95% three times, each 1.5 hours, merge extractive liquid,, reclaim ethanol, being concentrated into relative density is the extractum of 1.16-1.21 (55-60 ℃ of heat is surveyed), adds Radix Notoginseng, Olibanum (system), Myrrha (processed) fine powder and Camphora, Mentholum, Borneolum Syntheticum, methyl salicylate successively, gross weight by said medicine, other adds the doubly heavy substrate of being made by rubber, Colophonium of 3.7-4.0, stirs and makes coating, is coated with cream, cutting, the lid lining is cut into small pieces, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011316624A CN100335094C (en) | 2001-12-30 | 2001-12-30 | Notoginseng pain relieving plaster and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011316624A CN100335094C (en) | 2001-12-30 | 2001-12-30 | Notoginseng pain relieving plaster and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1429571A true CN1429571A (en) | 2003-07-16 |
| CN100335094C CN100335094C (en) | 2007-09-05 |
Family
ID=4670771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011316624A Expired - Lifetime CN100335094C (en) | 2001-12-30 | 2001-12-30 | Notoginseng pain relieving plaster and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100335094C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327872C (en) * | 2004-08-13 | 2007-07-25 | 赵长有 | Plaster for treating the bone disease |
| CN1330362C (en) * | 2005-04-21 | 2007-08-08 | 福州海王金象中药制药有限公司 | Wound dispelling swell dispersing tincture and its preparation method |
| CN100353996C (en) * | 2005-10-24 | 2007-12-12 | 广州中医药大学 | Medicine composition for treating soft tissue damage and osteoarthropathy and its prepn process |
| CN100364512C (en) * | 2005-08-25 | 2008-01-30 | 叶耀良 | Houjiling prepn for treating throat diseases and its use |
| CN101940672A (en) * | 2010-08-30 | 2011-01-12 | 昆明肾脏病研究所 | Medicament for curing gout and preparation method thereof |
| CN102078421A (en) * | 2010-12-08 | 2011-06-01 | 何永恒 | Chinese medicine external preparation for postoperative analgesia and healing promotion and preparation method thereof |
| CN104435323A (en) * | 2014-10-28 | 2015-03-25 | 王铁创 | Externally-applied traditional Chinese medicine composition for treating traumatic injury and administration mode thereof |
| CN115944677A (en) * | 2023-03-15 | 2023-04-11 | 赛灵药业科技集团股份有限公司北京分公司 | Notoginseng pain-relieving paste with stable effective components and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1129135A (en) * | 1995-09-28 | 1996-08-21 | 李绍魁 | Swelling-diminishing pain-relieving tincture |
| CN1240663A (en) * | 1999-06-28 | 2000-01-12 | 高福安 | Plaster for treating trauma, bone fracture and rheumatism and its preparing process |
-
2001
- 2001-12-30 CN CNB011316624A patent/CN100335094C/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327872C (en) * | 2004-08-13 | 2007-07-25 | 赵长有 | Plaster for treating the bone disease |
| CN1330362C (en) * | 2005-04-21 | 2007-08-08 | 福州海王金象中药制药有限公司 | Wound dispelling swell dispersing tincture and its preparation method |
| CN100364512C (en) * | 2005-08-25 | 2008-01-30 | 叶耀良 | Houjiling prepn for treating throat diseases and its use |
| CN100353996C (en) * | 2005-10-24 | 2007-12-12 | 广州中医药大学 | Medicine composition for treating soft tissue damage and osteoarthropathy and its prepn process |
| CN101940672A (en) * | 2010-08-30 | 2011-01-12 | 昆明肾脏病研究所 | Medicament for curing gout and preparation method thereof |
| CN102078421A (en) * | 2010-12-08 | 2011-06-01 | 何永恒 | Chinese medicine external preparation for postoperative analgesia and healing promotion and preparation method thereof |
| CN104435323A (en) * | 2014-10-28 | 2015-03-25 | 王铁创 | Externally-applied traditional Chinese medicine composition for treating traumatic injury and administration mode thereof |
| CN115944677A (en) * | 2023-03-15 | 2023-04-11 | 赛灵药业科技集团股份有限公司北京分公司 | Notoginseng pain-relieving paste with stable effective components and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100335094C (en) | 2007-09-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1228071C (en) | Medicament for treating cervical spondylosis and its preparation method | |
| CN1308012C (en) | Chinese medicine composition for treating cerebral hemorrhage and its prepn | |
| CN1055297A (en) | A kind of autofrettage of skin-moistening burn and scald medicine | |
| CN1586547A (en) | Medicine for treating bone wound | |
| CN100335094C (en) | Notoginseng pain relieving plaster and its preparation method | |
| CN101053618A (en) | Ointment for treating hyperplasia carbuncle wound and its preparing process | |
| CN1915375A (en) | Chinese traditional medicine for expeling wind and cold, relaxing muscles and tendons, harmonizing link and alleviating pain, and method for fabricating dog skin plaster purpose made | |
| CN102579583A (en) | External patch for treating injury of tendons and muscles | |
| CN102258633B (en) | Negundo chastetree fruit extract and application thereof | |
| CN1092981C (en) | Medicine for curing arthralgia-syndrome resulted from wind,cold and dampness and its preparation method | |
| CN1272066C (en) | Medicinal composition for relieving itching | |
| CN1723935A (en) | Paste for removing obstruction in channels to relieve pain for treating osteoarthritis, and its prepn. method | |
| CN1695682A (en) | External use preparation for treating rheumatisma and bone injuries | |
| CN101040949A (en) | Medicine compound for creating rheumatism and rheumatoid arthritis and the preparing method and apllication | |
| CN1663599A (en) | Improved plaster for treating rheumatic and rheumatoid diseases and preparation method thereof | |
| CN1186067C (en) | Medicine for curing acute injury of muscle and tendon and its preparation method | |
| CN1215595A (en) | External use medicine for treating soft tissue injury and its producing method | |
| CN110731992A (en) | paralysis plaster, its preparation method and paralysis plaster prepared thereby | |
| CN1203876C (en) | Medicine for curing postpartum subinvolution of uterus and its preparation method | |
| CN1899490A (en) | Liniment for treating acute and chronic soft tissue injury of qi stagnation and blood stasis and its preparing method | |
| CN1186058C (en) | Medicine for treating arthritis pain and its preparation method | |
| CN1762437A (en) | Bolus for treating rheumatic or rheumatoid arthritis and its preparation method | |
| CN1050298C (en) | Traditional Chinese medicine powder for bone-setting, and method for preparing same | |
| CN1201791C (en) | Wind dispelling and pain relieving ointment | |
| CN1323656C (en) | Medicine for treating rheumatic arthritis and preparation technology of its spray agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: SANJIU WEIKANG PHARMACEUTICAL CO., LTD., HUNAN PR Free format text: FORMER OWNER: HUNAN HENGYANG SANITARY MATERIAL CO., LTD. Effective date: 20050325 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20050325 Address after: 421001 Hunan city of Hengyang Province Huang Cha Ling No. 55 Applicant after: Sanjiu Weikang Pharmaceutical Co., Ltd., Hunan Prov. Address before: 421001 No. 55 Huang Cha Road, Hengyang, Hunan Applicant before: Hunan Hengyang Sanitary Material Co., Ltd. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20090109 Address after: Hunan city of Hengyang Province Huang Cha Ling No. 55 Patentee after: Hunan WICANDERS Pharmaceutical Co., Ltd. Address before: Hunan city of Hengyang Province Huang Cha Ling No. 55 Patentee before: Sanjiu Weikang Pharmaceutical Co., Ltd., Hunan Prov. |
|
| ASS | Succession or assignment of patent right |
Owner name: HUNAN WEIKANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SANJIU WEIKANG PHARMACEUTICAL CO., LTD., HUNAN PROV. Effective date: 20090109 |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20200131 Address after: 653100 Daying street, Hongta District, Yunnan, Yuxi Patentee after: YUNNAN CRYSTAL NATURAL PHARMACEUTICAL CO., LTD. Address before: 421008 Hunan city of Hengyang Province Huang Cha Ling No. 55 Patentee before: Hunan WICANDERS Pharmaceutical Co., Ltd. |
|
| TR01 | Transfer of patent right | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 653100 Daying street, Hongta District, Yunnan, Yuxi Patentee after: Sailing Pharmaceutical Technology Group Co., Ltd Address before: 653100 Daying street, Hongta District, Yunnan, Yuxi Patentee before: Yunnan Kress Pharmaceutical Co.,Ltd. |
|
| CP01 | Change in the name or title of a patent holder | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070905 |
|
| CX01 | Expiry of patent term |