CN1397251A - Pulse information measuring method and equipment for pickingup pulse pressure and blood flow at same time - Google Patents
Pulse information measuring method and equipment for pickingup pulse pressure and blood flow at same time Download PDFInfo
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Abstract
A method and equipment for measuring the pulse pressure, blood flow and blood flowering power and same time is disclosed. The diameter and position of arteria radialis at wrist are first measured by blood vessel measurer. The pulse pressures at adjacent positions on corist and measured by two pressure sensors and the delay time between them is obtained by the delay measurer. The pulse pressure of downstream is calculated according to that of upstream. The dynamic compliance of blood is then calulated. The blood viscosity is measured by the relative measurer. Finally, said three parameters can be calculated.
Description
Technical field:
The present invention is relevant with the human health status diagnosis, particularly a kind of pulse wave information measuring method and the device thereof that can obtain pulse pressure and blood flow simultaneously, especially refer to a kind ofly use two according to the pressure of the tandem pressure transducer synchronous measure of blood flow direction blood vessel and change waveform etc., and then calculate the method for measurement and the device thereof of blood vessel Cdgn dyanamic compliance, blood flow and blood flow kinetic energy.
Background technology:
Present various pulse wave method for measurement all is to be used as the message that health status is judged with the variation that measures pulse pressure and waveform thereof, or transfers pulse pressure to frequency spectrum analyzed, and except the measurement of pulse pressure, also has with the Doppler ultrasound wave to measure blood flow; Measure methods such as blood flow rate with infrared ray sensing erythrocyte translational speed, but these methods all can only obtain single message respectively, just can obtain a plurality of messages by multistep, and the message of single pulse pressure, blood flow or flow velocity all is not enough to characterize the good working condition of heart and blood vessel, because under the identical pulse pressure may because of the difference of individual blood vessels caliber, vascular compliance on an equal basis different blood flows is not arranged, physical condition is also closely bound up with blood flow kinetic energy still more.This all variation is not that the message of single pulse pressure, blood flow or flow velocity can reflect.Have only a plurality of composite messages of acquisition, could make the judgement that gears to actual circumstances the state of heart and blood vessel.
The inventor learns not only based on years of researches will measure endovascular pressure, also will obtain the message of vascular flow simultaneously, both could be multiply by mutually to obtain endovascular blood flow energy, and technically, can calculate blood flow by 2 pressure differential.
If supposing blood flow is laminar flow, blood vessel is linear elastic tube, and the elastic vessel blood flow formula of being derived according to the auspicious academician of Feng Yuan is
In the formula:
Q is a blood flow
α=Δ a/p is a vascular compliance
Wherein p is a pulse pressure waveform instantaneous value, and Δ a is the changing value of blood vessels caliber
L is the distance of two amount of pressure measuring points
μ is the blood coefficient of viscosity
a
0Caliber for blood vessel
P (O), P (L) are the pulse pressure value of two amount of pressure measuring points
Therefore, as desire to obtain blood flow, then must obtain vascular compliance α, blood coefficient of viscosity μ, blood vessels caliber a with aforementioned formula
0, pulse pressure value P (O), the P (L) of two amount of pressure measuring points and the distance L of two amount of pressure measuring points, these numerical value are not to measure single message in the present various method for measurement can provide.
Especially, the distance L of two measuring points is shorter more can try to achieve blood flow more accurately, but 2 the approaching pressure differential that heals more is difficult to measurement, and with the viewpoint of pulse wave spectrum, it is good in the scope of a finger tip that the distance of these two measuring points needs.According to studies show that of the inventor, the distance L of two measuring points that define in the finger tip scope is about 2～3mm, and the pressure velocity of wave that pulse pressure is passed through at the wrist portion radial artery is about 3.5～4.5 meter per seconds, thus the time of pulse wave by these two measuring points be about 0.5 millisecond, please refer to Fig. 1.And the acquisition frequency of general curative diagnostic instruments is about 200～400Hz, is about 25～50 milliseconds its sample time, and obviously, present employed Medical Instruments is that the difference that can't manifest two measuring point pulse pressure values changes.
And following one by one problem is, distance approaching pulse pressure difference like this is minimum, the percentage error of adding in the measurement is not little, when simulating the digital error that is produced when the pulse pressure signal converts the digital signal of 12bit to, and can cause equally the problem that the pulse pressure value that can't differentiate two measuring points and difference change.
The great parameter that another one influences blood flow calculating is vascular compliance α, aforementioned blood flow formula is the elastic vessel for ideal, its compliance α is assumed to be constant, but relevant carotid studies show that, actual compliance α is a non-linear value, and also different when diastolic pressure and systolic pressure, therefore measuring Cdgn dyanamic compliance α is a problem that must overcome.
Vascular compliance α is defined as the ratio of this blood vessels caliber change in displacement and pulse pressure.In other words, the slope of this caliber displacement one-pressure curve just.Therefore, as if only need a pressure transducer be set and a displacement transducer gets final product at measuring point, but in fact really not so simple: at first if will obtain the pressure of this point changes, blood vessel need be fixed and push to the pressure transducer of this point in certain degree of depth; Shrink displacement if measure the expansion of blood vessel under the relative pressure, need the size of pressure sensor and movable sensor.But because pressure transducer and displacement driver are one, when pressure transducer moved, the pressure of also losing this point simultaneously changed, and causes calculating Cdgn dyanamic compliance.
In sum, pulse pressure value P (O), the P (L) of two measuring points that distance is so approaching obviously can't obtain with the existing direct measurement of measurement mode, and the compliance α of blood vessel also can't obtain with present measurement mode.
Summary of the invention:
The technical problem to be solved in the present invention is to overcome the deficiency of above-mentioned prior art, provide a kind of method for measurement and measuring equipment thereof of obtaining the pulse wave message of pulse pressure and blood flow simultaneously, with pulse pressure P (O), P (L), blood vessel Cdgn dyanamic compliance α, blood flow Q and the energy of flow E of blood in blood vessel of synchronization gain two adjacent measuring points.
Technical solution of the present invention is as follows:
A kind of pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously is characterized in that this method comprises the following steps:
1. along blood flow direction keep at a certain distance away arrange a upstream pressure sensor and a downstream pressure transducer to two at the same position of human vas mutually neighbour's point measure; With the pulse pressure P (O) that captures this upstream pressure sensor place and the pulse pressure P (L) at downstream pressure sensor place, obtain the delay time T that pulse wave passes through between the pressure transducer of upstream and downstream via a delay detection circuit again, and P (O) and τ imported a data processing equipment, capture the corresponding digital pulse compression P of this upstream pressure sensor (O) simultaneously, delayed time τ calculates the pulse pressure P (L) that tries to achieve the downstream pressure sensor place;
2. measure the displacement variable Δ a of downstream pressure sensor place blood vessels caliber with a displacement transducer;
3. measure the blood vessels caliber a at downstream pressure sensor place with a blood vessels caliber measuring equipment
0
4. with the coefficient of viscosity μ of titration measuring blood;
The pulse pressure P (O) at the pressure transducer place, upstream and downstream that 5. above-mentioned steps is obtained, P (L), range difference L and the blood vessels caliber a of downstream pressure sensor place
0And messages such as caliber displacement variable Δ a and blood coefficient of viscosity μ, calculate vascular compliance α and blood flow Q by following formula.
α＝ΔaP(L)
The distance of this upstream and downstream pressure transducer is 2～3mm.
This upstream and downstream pressure transducer system inserts in the blood vessel with the mode of infection, to measure the blood pressure of intubate inside, obtains pulse pressure.
This upstream and downstream pressure transducer system is to be pressed on the skin histology at human vas place under the non-intruding mode.
That the degree of depth system that is pressed in human vas place skin histology under this upstream and downstream pressure transducer cooperates is floating in the pulse wave spectrum, in, heavy three kinds of arteries and veins positions and deciding.
This upstream and downstream pressure transducer system is pressed on the cun,guan,chi position of human body wrist radial artery down.
This downstream pressure sensor system drives an actuator with controller and drives that this downstream pressure sensor is upper and lower to be moved, so that the pressure sensor value of this downstream pressure sensor reality levels off to zero, and measure the upper and lower mobile displacement of this downstream pressure sensor with said displacement transducer, to obtain the displacement variable Δ a of blood vessels caliber.
Place the displacement variable Δ a of downstream pressure sensor place direct sensing blood vessels caliber with a displacement transducer.
A kind of pulse wave information measuring device that can obtain pulse pressure and blood flow simultaneously is characterized in that it comprises:
One intubate, this intubate has one for the puncture portion of passing in the human skin tissue intravasation, have in this intubate according to spaced two runners of blood flow direction, each runner is penetrated out by this puncture portion respectively and has an opening, this intubate is provided with a pedestal with respect to the other end of puncture portion, this pedestal is respectively equipped with a room to two runners in should intubate, is respectively equipped with a pressure transducer in each room, for the pressure that measures in each runner;
One probe tube, an end of this probe tube is for inserting in the human vas, and this probe tube then can supply blood sampling to measure blood coefficient of viscosity μ with respect to the other end that inserts human body;
One blood vessels caliber measuring equipment is used to measure blood vessels caliber;
One displacement transducer, it is the place, tip that is located at a needle body, this needle body system is plugged in corresponding to this intubate meta in the skin histology of the opening part of the runner of downstream part, to be positioned at the blood vessels caliber offset variable of the runner opening part of downstream part in this this intubate of displacement transducer sensing.
A kind of pulse wave information measuring device that can obtain pulse pressure and blood flow simultaneously is characterized in that it comprises:
One fixture comprises a pedestal, is provided with a holding part in the pedestal, and these holding part both sides have the gas cell bag;
One blood vessels caliber measuring equipment, it is arranged at this pedestal
One pressure-sensing device, be arranged at this pedestal, this pressure-sensing device is provided with a pedestal at least corresponding to blood vessel, this pedestal is driven by a driven unit and can press down human vas, the compartment of terrain is provided with a upstream pressure sensor and a downstream pressure transducer in this pedestal, a this upstream and downstream pressure transducer and a circuit are connected, and in this pedestal and be provided with one in order to drive the actuator of the upper and lower displacement of downstream pressure sensor;
One displacement transducer is used for detecting the upper and lower mobile displacement of this downstream pressure sensor;
Divide into displacement transducer on the said downstream pressure sensor, other establishes a displacement transducer and second actuator thereof.
This blood vessels caliber measuring equipment is a hot display, and this hot display has a hot video picture chipset and an image process unit.
This hot display can measure body temperature simultaneously.Technique effect of the present invention is as follows:
1, keep at a certain distance away to arrange along blood flow direction and a upstream pressure sensor is set and a downstream pressure transducer comes the same position of human vas is measured, it captures the pulse pressure P (O) at this upstream pressure sensor place and the pulse pressure P (L) at downstream pressure sensor place, obtain via a delay detection circuit again, the delay time T that pulse wave passes through between downstream pressure sensor, and P (O) and τ imported a data processing equipment, capture the digital pulse compression P (O) of this upstream pressure sensor simultaneously, delayed time τ calculates the digital pulse compression P (L) that tries to achieve the downstream pressure sensor place, can obtain the digital pulse compression P (O) of two adjacent measuring points synchronously, the purpose of P (L).
2, drive an actuator by controller with the loop control mode and drive that this downstream pressure sensor is upper and lower to be moved, so that the pressure sensor value of this downstream pressure sensor reality levels off to zero, and measure the upper and lower mobile distance of this downstream pressure sensor with displacement transducer, to obtain the displacement variable of blood vessels caliber, can further calculate the Cdgn dyanamic compliance α of blood vessel.
3, measure the demonstration vessel position with a hot display, to measure the automatization location of position as pressure-sensing device, and can measure blood vessels caliber and human body temperature, detect the coefficient of viscosity of blood again by the blood viscosity detector, the Cdgn dyanamic compliance α that can cooperate obtained blood vessel, obtain blood flow Q as calculated, and then calculate blood mobile ENERGY E in blood vessel.
4, the mat associated dynamic data such as wrist portion temperature, blood vessel pulse pressure, Cdgn dyanamic compliance, blood vessels caliber, blood flow and blood flow kinetic energy of trying to achieve, cooperate clinical diagnosis, essence is got every physiological parameter, and through numerical statistic, pulse-taking clinical diagnosis data base is set up in analysis, as the reference of Chinese and western medicine clinic diagnosis.
Description of drawings:
Fig. 1 is the potential difference sketch map that pulse wave passes through two adjacent measuring points.
Fig. 2 is the configuration schematic diagram of first embodiment of the invention device.
Fig. 3 is the user mode sketch map that the first embodiment of the invention intrusive mood measures.
Fig. 4 is the method for measurement control flow chart of first embodiment of the invention.
Fig. 5 is apparatus of the present invention second embodiment sketch maps.
Fig. 6 is the pressure-sensing device structural representation of second embodiment of the invention.
Fig. 7 is one of second embodiment of the invention user mode sketch map.
Fig. 8 is a second embodiment of the invention method for measurement control flow chart.
Fig. 9 is two of a second embodiment of the invention user mode sketch map.
Figure 10 is apparatus of the present invention the 3rd example structure and uses sketch map ().
Figure 11 is apparatus of the present invention the 3rd example structure and uses sketch map (two).
Among the figure:
1-intubate 11-puncture portion
12,13-runner 121,131-opening
14-probe tube 15-pedestal
16,17-pressure transducer 18-blood viscosity detector
19-displacement transducer 191-needle body
The hot display 3-of 2-wrist fixture
30-pedestal 31-holding part
The hot display of 32-capsule bag 4-
5-pressure-sensing device 51-pedestal
52-upstream pressure sensor 53-downstream pressure sensor
522-upstream pressure microsensor 532-downstream pressure microsensor
521,531-housing 523,533-cover body
524,534-room 526,536-compression zone
54-actuator 55-driven unit
56,56A-displacement transducer 57-second actuator
The specific embodiment:
See also Fig. 2 and Fig. 3, be the pulse wave information measuring method of pulse pressure and blood flow and first embodiment of device thereof of can obtaining simultaneously of the present invention shown in the figure, present embodiment system forms with intrusive mood method for measurement framework, and it comprises:
One intubate 1, this intubate 1 has a puncture portion 11 for passing in the human skin tissue intravasation, have in this intubate 1 according to spaced two runners 12,13 of blood flow direction, the about 2-3mm of spacing distance of this two runner 12,13, each runner 12,13 is penetrated out by this puncture portion 11 respectively and has an opening 121,131, this intubate 1 is provided with a pedestal 15 with respect to the other end of puncture portion 11,15 pairs of this pedestals, two runners 12,13 in should intubate 1 are respectively equipped with a pressure transducer 16,17, for the pressure that measures in each runner 12,13.
One probe tube 14, an end of this probe tube 14 is in the insertion human vas, and this probe tube 14 is provided with a blood viscosity detector 18 with respect to the other end that inserts human body, supplies blood sampling to measure the coefficient of viscosity μ of blood.And this blood viscosity detector 18 can be with made blood viscosity detectors of form such as erythrocyte sedimentation or titrimetrys.
One displacement transducer 19, it is located at the place, tip of a needle body 191, in the present embodiment, this displacement transducer 19 is the light sensation inductive transducer, and this needle body 191 be plugged in to should intubate 1 meta in the skin histology at opening 131 places of the runner 13 of downstream part, with blood vessels caliber offset variable Δ a by runner 13 openings 131 places that are positioned at downstream part in this this intubate 1 of displacement transducer 19 sensings.
One blood vessels caliber measuring equipment, in the present embodiment, system with a hot display 2 as the blood vessels caliber measuring equipment, this hot display 2 is provided with has a hot video picture chipset and an image process unit, this hot video picture chipset can be covered on the skin tissue surface at tested blood vessel place, with the position and the caliber a of detecting blood vessel
0Size, but and the body temperature T of synchronous measure testee.
One data processing equipment (not shown), it is to link with aforesaid pressure transducer 16,17, blood viscosity detector 18, displacement transducer 19 and hot display 2, will measure the every signal and the data of gained, carry out computing, obtain data such as pulse pressure, compliance, blood flow and blood flow kinetic energy, according to clinical medicine acquisition eigenvalue, provide the reference on the tcm diagnosis again.
When present embodiment uses in reality, be the skin tissue surface that is covered on tested blood vessel place earlier with hot display 2, as shown in Figure 2, the position and the caliber size of detecting blood vessel.Remove hot display 2 again, the needle body 191 of intubate 1 with displacement transducer 19 inserted in blood vessel and the skin histology, as shown in Figure 3, the work that measures.
See also Fig. 4, the pulse pressure P (O) and the P (L) of two runners 12,13 of measurement control flow system's elder generation's acquisition of the present invention; Obtain delay time T via delay detection circuit, the input data processing equipment, the digital pulse compression P (O) with the DAQ gained is a benchmark simultaneously, postpones this time difference τ, calculates the digital pulse compression P (L) at pressure transducer 17 places.
Immediately by data processing equipment blood coefficient of viscosity μ, blood vessels caliber offset variable Δ a, the blood vessels caliber a that displacement transducer 19 records that blood viscosity detector 18 is measured
0And runner 12 pulse pressure P (O) and the obtained P common computings of data information such as (L) of delay calculating, can try to achieve data such as vascular compliance α, blood flow Q and blood flow kinetic energy E synchronously, to compare according to the various eigenvalues that clinical medicine captured among each obtained data and the data base again, Chinese medicine diagnosis reference is provided.
Fig. 5 is the second embodiment of the present invention, and it is the measuring equipment of non-intrusion type, and the measuring equipment that can obtain vascular compliance and blood flow simultaneously of present embodiment comprises:
One wrist fixture 3, this wrist fixture 3 has a pedestal 30, be provided with a holding part 31 in this pedestal 30, wrist portion is held in this holding part 31 with wrist radial artery posture up for user, and these holding part 31 both sides have inflatable capsule bag 32, mat capsule bag 32 inflation and wrist is inserted and put fixing and does not suffer oppression wrist radial artery place.
One blood vessels caliber measuring equipment, in the present embodiment, system with a hot display 4 as the blood vessels caliber measuring equipment, this hot display 4 is to be arranged on the pedestal 30 of wrist fixture 3, it has a hot video picture chipset and an image process unit, this hot video picture core group is driven and is covered on above the wrist radial artery place, the position and the caliber size thereof of detecting radial artery.
One pressure-sensing device 5, it is arranged on the pedestal 30 of wrist fixture 3, the position, pass of its corresponding radial artery has a pedestal 51, see also Fig. 6, this pedestal 51 is driven by a driven unit 55 and can be pressed on the radial artery of wrist down, the haul distance that these driven unit 55 promotion pedestals 51 move is about about 10mm, this pedestal 51 is interval with the downstream pressure sensor 53 that a upstream pressure sensor 52 and that is positioned at upstream extremity is positioned at downstream along blood flow direction, the about 2-3mm of spacing distance of this upstream and downstream pressure transducer 52,53.
On being somebody's turn to do, downstream pressure sensor 52,53 structure has a hollow housing 521 respectively, 531, this housing 521 respectively, be respectively equipped with a upstream pressure microsensor 522 and a downstream pressure microsensor 532 in 531, and on being somebody's turn to do, downstream pressure microsensor 522,532 outer rims are covered with the cover body 523 that an elastomeric material is made respectively, 533, and each cover body 523,533 is interior and last, downstream pressure microsensor 522,532 are formed with a room 524 respectively, 534, each room 524, be filled with silicone oil in 534 respectively, and each cover body 523,533 front ends have one respectively and protrude from housing 521,531 outer compression zones 526,536, and this compression zone 526 respectively, 536 is that on-deformable hard material constitutes during by pressurized, when each compression zone 526, during 536 pressurizeds, oppress each room 524 respectively, silicone oil in 534, with by last, downstream pressure microsensor 522,532 sense the pressure of pressurized, and on being somebody's turn to do, downstream pressure microsensor 522,532 are connected with a ware circuit again, and in this pedestal 51 and be provided with one in order to drive on the downstream pressure sensor 53, the actuator 54 of bottom offset, in the present embodiment, this actuator is by marmem and (not shown) that dependency structure is formed, form the memorial alloy sheet and is connected, the variation of generation shape when the marmem sheet is switched on and producing on the thrust promotion downstream pressure sensor 53 with power supply, bottom offset.Certainly, this brake 54 also can be used the minute-pressure electric actuator except being made up of marmem and associated mechanisms, or other fine motion brake.In addition at brake 54 back device one displacement transducers 56, with the shift value of sensing blood vessels caliber.
One data processing equipment, it is that every signal and data that hardware circuit is measured gained are carried out computing, obtains data such as pulse pressure, vascular compliance, blood flow and blood flow kinetic energy, according to clinical medicine acquisition eigenvalue, provides the reference of Chinese and western medicine diagnosis again.
Present embodiment is when measuring adjacent two pulse pressures, promoting pedestal 51 by driven unit moves down, make pressure transducer 52,53 compressings in upstream and downstream on the radial artery of wrist, as shown in Figure 7, this upstream and downstream pressure transducer 52,53 presses down the back and keeps motionless, make its compression zone 526,536 be subjected to the pulse pressure pushing tow upwards, make compression zone 526,536 pressure that born be passed to upstream and downstream pressure microsensor 522,532.See also Fig. 8 again, the measurement control flow of present embodiment 2 is: driven unit promotes pedestal 51 and moves down, make pressure transducer 52,53 compressings in upstream and downstream when the radial artery of wrist, earlier the pulse pressure P (O) and the P (L) of two measuring points of acquisition; Obtain delay time T via a delay detection circuit again, again P (O) and τ are imported a data processing equipment, capture the digital pulse compression P (O) of this upstream pressure sensor, and postpone this time, calculate the pulse pressure P (L) of downstream pressure sensor.
See also Fig. 8, when promoting pedestal 51, driven unit moves down, make, downstream pressure sensor 52,53 compressings are behind the radial artery of wrist, can be via a controller drive actuator 54, drive that this downstream pressure sensor 53 changes along with pulse pressure and on, move down, the force value that makes 532 sensings of this downstream pressure microsensor is to level off to little contact condition of zero, and the displacement that this actuator 54 drives downstream pressure sensor 53 can be detected by displacement transducer 56, be the variation displacement a of blood vessels caliber, Δ a and the pulse pressure estimated value P (L) that passes through back micropressure sensor 532 places that postpone to calculate and obtain are calculated its rate of change, promptly obtain blood vessel Cdgn dyanamic compliance α.
Be to measure the blood coefficient of viscosity μ of testee with the blood viscosity detector in the present embodiment, if when being inconvenient to measure, five multiple value of the coefficient of viscosity that can also water are as the coefficient of viscosity μ of blood.
Moreover, because the hot video picture chipset of hot display can have 128 * 128 hotness lattice point in 1cm * 1cm, can sense the temperature difference of 40mk, therefore can be by the temperature difference between blood flow and surrounding tissue, the image that presents the blood vessel profile is estimated by image processing technique and vessel position and caliber a
0, for the usefulness of feeling the pulse location.When measuring blood vessels caliber, hot video picture chipset also can be with pacing body temperature T.
When actual use is of the present invention, testee blood drawing is earlier measured blood coefficient of viscosity μ with the blood viscosity detector, the wrist of testee is held in the holding part 31 of wrist fixture 3 with radial artery posture up again, wrist is inserted and put fixing by capsule bag 32 inflations of both sides again, as shown in Figure 9, and wrist radial artery B place is not suffered oppression, driving hot display 4 again makes hot video picture chip place wrist radial artery B top, the temperature difference between detecting radial artery B and surrounding tissue obtains the position of radial artery B and the caliber a of radial artery with measurement
0, and record the body temperature T of human body simultaneously; And after hot display 4 is backed out, driven unit 55 driving pedestals by pressure-sensing device 5 are pressed in wrist radial artery place for 51 times, make upstream and downstream pressure transducer 52,53 be pressed against position, the pass B2 of wrist radial artery B, as shown in Figure 9, this upstream and downstream pressure transducer 52,53 presses down the back and keeps motionless earlier, measure pulse pressure signal P (O) and P (L), detect delay time T via delay detection circuit; Level off to the state of zero (pressure of little contact) with the actual sensed pressure of control downstream pressure microsensor 532 immediately, and drive downstream pressure sensor 53 upper and lower moving, obtain the displacement Δ a that downstream pressure sensor 53 upper and lower amount of movements are caliber by displacement transducer 56 measurements; Digital pulse compression P (O) with upstream pressure microsensor 522 is a benchmark, does the delay of time difference τ, calculates the digital pulse compression P (L) at downstream pressure sensor 53 places, obtains blood vessel displacement one sphygmobologram, and differential can obtain blood vessel Cdgn dyanamic compliance α after handling.Calculate blood flow and blood flow kinetic energy according to the blood flow formula at last, provide further feature analysis, as the reference of Chinese and western medicine clinical diagnosis.
When measuring, driven unit drive the stroke degree of depth that pedestal 51 presses down can cooperate floating in the pulse wave spectrum, in, heavy three kinds of powers carry out respectively.
Certainly, for cooperating pulse wave spectrum very little, close, the feeling the pulse at chi position, except aforementioned corresponding radial artery closes the set sensing apparatus of position B2, also can distinguish the CUN position B1 and the chi position B3 of corresponding radial artery, as sign person among Fig. 9, respectively set up a detection sensor, be respectively equipped with a sensing body in each sensing apparatus, a built-in pressure microsensor, very little and the chi position B1 with sensing, the pulse pressure of B3, each pressure microsensor can be pressed down the very little and chi position B1 of wrist radial artery respectively respectively by driven unit driving, B3, with can cooperate aforementioned corresponding radial artery close in the set sensing apparatus of position B2 on, downstream pressure sensor, and simultaneously by in three sensing apparatus totally four pressure microsensors simultaneously the sensing radial arterys cun, close, the pulse pressure at three positions of chi and pulse pressure change waveform, obtain more detailed pulse wave and change data, to promote the accuracy that pulse-taking is judged.
Figure 10, Figure 11 are the structures of apparatus of the present invention embodiment 3 and use sketch map.Present embodiment and Fig. 6 embodiment 2 are basic identical, and its difference is no longer to establish displacement transducer 56 on this downstream pressure sensor 53, and other is provided with a displacement transducer 56A and second actuator 57 thereof.After the upstream and downstream pressure transducer is measured P (O), τ, mention after this downstream pressure sensor 53, this displacement transducer 56A places the change in displacement Δ a of these downstream pressure sensor 53 part direct sensing blood vessels under the driving of actuator 57.Thereby capture the digital pulse compression p (O) of upstream pressure sensor and the displacement a of downstream bits displacement sensor place blood vessel simultaneously, send into data processing unit such as computer (PC), digital signal processor (DSP), single-chip controller etc., go out the downstream pulse pressure with the delayed Time Calculation of upstream pulse pressure, with the downstream displacement data, calculate the Cdgn dyanamic compliance of downstream blood vessel again.
The above embodiment is not that promptly the displacement of the change of numerical value or equivalent elements must belong to protection scope of the present invention such as in order to restriction the present invention only in order to explanation the present invention.
Claims (12)
1, a kind of pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously is characterized in that this method comprises the following steps:
1. along blood flow direction keep at a certain distance away L arrange a upstream pressure sensor and a downstream pressure transducer to two at the same position of human vas mutually neighbour's point measure; With the pulse pressure P (O) that captures this upstream pressure sensor place and the pulse pressure P (L) at downstream pressure sensor place, obtain the delay time T that pulse wave passes through between the pressure transducer of upstream and downstream via a delay detection circuit, and P (O) and τ imported a data processing equipment, capture the corresponding digital pulse compression P of upstream pressure sensor (O) simultaneously, delayed time τ calculates the pulse pressure P (L) that tries to achieve the downstream pressure sensor place;
2. measure the displacement variable Δ a of downstream pressure sensor place blood vessels caliber with a displacement transducer;
3. measure the blood vessels caliber a at downstream pressure sensor place with a blood vessels caliber measuring equipment
0
4. measure blood coefficient of viscosity μ with the blood viscosity detector;
The pulse pressure P (O) at the pressure transducer place, upstream and downstream that 5. above-mentioned steps is obtained, P (L), range difference L and the blood vessels caliber a of downstream pressure sensor place
0And messages such as caliber displacement variable Δ a and blood coefficient of viscosity μ, calculate vascular compliance α and blood flow Q by following formula.
α＝Δa/P(L)
2, the pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously according to claim 1, the distance L that it is characterized in that this upstream and downstream pressure transducer is 2～3mm.
3, the pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously according to claim 1 is characterized in that this upstream and downstream pressure transducer system inserts in the blood vessel with the mode of infection, to measure the blood pressure of intubate inside, obtains pulse pressure.
4, the pulse wave message method that can obtain pulse pressure and blood flow simultaneously according to claim 1 is characterized in that this upstream and downstream pressure transducer system is to be pressed on the skin histology at human vas place under the non-intruding mode.
5, the pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously according to claim 4, that the degree of depth system that it is characterized in that being pressed under this upstream and downstream pressure transducer human vas place skin histology cooperates is floating in the pulse wave spectrum, in, heavy three kinds of arteries and veins positions and deciding.
6, the pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously according to claim 4 is characterized in that this upstream and downstream pressure transducer system is pressed on the cun,guan,chi position of human body wrist radial artery down.
7, the pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously according to claim 4, it is characterized in that this downstream pressure sensor system drives an actuator with controller and drives that this downstream pressure sensor is upper and lower to be moved, so that the pressure sensor value of this downstream pressure sensor reality levels off to zero, and measure the upper and lower mobile displacement of this downstream pressure sensor with said displacement transducer, to obtain the displacement variable Δ a of blood vessels caliber.
8, the pulse wave information measuring method that can obtain pulse pressure and blood flow simultaneously according to claim 4 is characterized in that placing with a displacement transducer displacement variable Δ a of downstream pressure sensor place direct sensing blood vessels caliber.
9, a kind ofly implement the pulse wave information measuring device that the described method for measurement of claim 1 can be obtained pulse pressure and blood flow simultaneously, it is characterized in that it comprises:
One intubate, this intubate has one for the puncture portion of passing in the human skin tissue intravasation, have in this intubate according to spaced two runners of blood flow direction, each runner is penetrated out by this puncture portion respectively and has an opening, this intubate is provided with a pedestal with respect to the other end of puncture portion, this pedestal is respectively equipped with a room to two runners in should intubate, is respectively equipped with a pressure transducer in each room, for the pressure that measures in each runner;
One probe tube, an end of this probe tube is for inserting in the human vas, and this probe tube then can supply blood sampling to measure blood coefficient of viscosity μ with respect to the other end that inserts human body;
One blood vessels caliber measuring equipment is used to measure blood vessels caliber;
One displacement transducer, it is the place, tip that is located at a needle body, this needle body system is plugged in corresponding to this intubate meta in the skin histology of the opening part of the runner of downstream part, to be positioned at the blood vessels caliber offset variable of the runner opening part of downstream part in this this intubate of displacement transducer sensing.
(52) with a downstream pressure transducer (53), this upstream and downstream pressure transducer and a circuit are connected, and in this pedestal (51) and be provided with an actuator (54) in order to driving downstream pressure sensor (53) upper and lower displacement;
One displacement transducer (56) is used for detecting the upper and lower mobile displacement of this downstream pressure sensor (53);
10, the pulse wave information measuring device that can obtain pulse pressure and blood flow simultaneously according to claim 10, it is characterized in that not establishing displacement transducer (56) on the said downstream pressure sensor (53), and set a displacement transducer (56A) and second actuator (57) thereof in addition.
11, according to claim 9 or the 10 or 11 described pulse wave information measuring devices that can obtain pulse pressure and blood flow simultaneously, it is characterized in that this blood vessels caliber measuring equipment is a hot display, this hot display has a hot video picture chipset and an image process unit.
12, the pulse wave information measuring device that can obtain pulse pressure and blood flow simultaneously according to claim 12 is characterized in that this hot display can measure body temperature simultaneously.
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| CN 02112432 CN1229074C (en) | 2002-07-09 | 2002-07-09 | Pulse information measuring method and equipment for pickingup pulse pressure and blood flow at same time |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2387916A (en) * | 2002-04-26 | 2003-10-29 | E Med Biotech Inc | Sphygmogram measurement involving calculation of blood flow rate |
| CN1299639C (en) * | 2003-04-04 | 2007-02-14 | 欧姆龙健康医疗事业株式会社 | Pulse wave measuring apparatus |
| CN105658138A (en) * | 2013-06-14 | 2016-06-08 | 诺瓦达克技术公司 | Quantification of absolute blood flow in tissue using fluorescence mediated photoplethysmography |
| CN105769140A (en) * | 2016-03-21 | 2016-07-20 | 安徽工程大学 | Multi-point radial artery pulse condition acquisition system and method |
| CN106999064A (en) * | 2014-11-13 | 2017-08-01 | 范德堡大学 | Apparatus and method and its application of recovery are detected and guided for bleeding |
| CN108403093A (en) * | 2018-02-27 | 2018-08-17 | 京东方科技集团股份有限公司 | Devices and methods therefor for the position for determining blood vessel |
| CN108784664A (en) * | 2018-06-28 | 2018-11-13 | 上海掌门科技有限公司 | Pulse diagnosing device based on pressure sensor and image capture device |
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2002
- 2002-07-09 CN CN 02112432 patent/CN1229074C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2387916A (en) * | 2002-04-26 | 2003-10-29 | E Med Biotech Inc | Sphygmogram measurement involving calculation of blood flow rate |
| GB2388913A (en) * | 2002-04-26 | 2003-11-26 | E Med Biotech Inc | Sphygmogram measurement of pulse pressure at two adjacent points |
| GB2388913B (en) * | 2002-04-26 | 2006-04-26 | E Med Biotech Inc | Sphygmogram measurement of pulse pressure at two adjacent points |
| GB2387916B (en) * | 2002-04-26 | 2006-06-14 | E Med Biotech Inc | Sphygmogram measurement involving calculation of blood flow rate |
| CN1299639C (en) * | 2003-04-04 | 2007-02-14 | 欧姆龙健康医疗事业株式会社 | Pulse wave measuring apparatus |
| CN105658138A (en) * | 2013-06-14 | 2016-06-08 | 诺瓦达克技术公司 | Quantification of absolute blood flow in tissue using fluorescence mediated photoplethysmography |
| CN106999064A (en) * | 2014-11-13 | 2017-08-01 | 范德堡大学 | Apparatus and method and its application of recovery are detected and guided for bleeding |
| CN105769140A (en) * | 2016-03-21 | 2016-07-20 | 安徽工程大学 | Multi-point radial artery pulse condition acquisition system and method |
| CN108403093A (en) * | 2018-02-27 | 2018-08-17 | 京东方科技集团股份有限公司 | Devices and methods therefor for the position for determining blood vessel |
| US11311236B2 (en) | 2018-02-27 | 2022-04-26 | Boe Technology Group Co., Ltd. | Device for determining location of blood vessel and method thereof |
| CN108784664A (en) * | 2018-06-28 | 2018-11-13 | 上海掌门科技有限公司 | Pulse diagnosing device based on pressure sensor and image capture device |
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