CN1313750A - 包含细碳酸钙和粗碳酸钙的牙膏 - Google Patents
包含细碳酸钙和粗碳酸钙的牙膏 Download PDFInfo
- Publication number
- CN1313750A CN1313750A CN99809891A CN99809891A CN1313750A CN 1313750 A CN1313750 A CN 1313750A CN 99809891 A CN99809891 A CN 99809891A CN 99809891 A CN99809891 A CN 99809891A CN 1313750 A CN1313750 A CN 1313750A
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- CN
- China
- Prior art keywords
- calcium carbonate
- toothpaste
- microns
- weight
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 title claims abstract description 97
- 229910000019 calcium carbonate Inorganic materials 0.000 title claims abstract description 46
- 239000000606 toothpaste Substances 0.000 title claims abstract description 32
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 claims abstract description 18
- 239000002245 particle Substances 0.000 claims description 22
- 239000006072 paste Substances 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 abstract description 4
- 239000012459 cleaning agent Substances 0.000 abstract 1
- 235000010216 calcium carbonate Nutrition 0.000 description 31
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000008187 granular material Substances 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- -1 hydroxyl diphenyl ether Chemical compound 0.000 description 4
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000003082 abrasive agent Substances 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 239000007844 bleaching agent Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
- 229940038472 dicalcium phosphate Drugs 0.000 description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
- WJJMNDUMQPNECX-UHFFFAOYSA-N dipicolinic acid Chemical compound OC(=O)C1=CC=CC(C(O)=O)=N1 WJJMNDUMQPNECX-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 235000010356 sorbitol Nutrition 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- DTOUUUZOYKYHEP-UHFFFAOYSA-N 1,3-bis(2-ethylhexyl)-5-methyl-1,3-diazinan-5-amine Chemical compound CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 DTOUUUZOYKYHEP-UHFFFAOYSA-N 0.000 description 1
- GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- PXRKCOCTEMYUEG-UHFFFAOYSA-N 5-aminoisoindole-1,3-dione Chemical compound NC1=CC=C2C(=O)NC(=O)C2=C1 PXRKCOCTEMYUEG-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- 108010062877 Bacteriocins Proteins 0.000 description 1
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
- 229940123208 Biguanide Drugs 0.000 description 1
- 239000001736 Calcium glycerylphosphate Substances 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- 229940090898 Desensitizer Drugs 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- FCEXWTOTHXCQCQ-UHFFFAOYSA-N Ethoxydihydrosanguinarine Natural products C12=CC=C3OCOC3=C2C(OCC)N(C)C(C2=C3)=C1C=CC2=CC1=C3OCO1 FCEXWTOTHXCQCQ-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000019738 Limestone Nutrition 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000001785 acacia senegal l. willd gum Substances 0.000 description 1
- 229960001138 acetylsalicylic acid Drugs 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229960005363 aluminium oxide Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002690 anti-lithiasic effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229920005601 base polymer Polymers 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- UHHRFSOMMCWGSO-UHFFFAOYSA-L calcium glycerophosphate Chemical compound [Ca+2].OCC(CO)OP([O-])([O-])=O UHHRFSOMMCWGSO-UHFFFAOYSA-L 0.000 description 1
- 229940095618 calcium glycerophosphate Drugs 0.000 description 1
- 235000019299 calcium glycerylphosphate Nutrition 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000013877 carbamide Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- QUQFTIVBFKLPCL-UHFFFAOYSA-L copper;2-amino-3-[(2-amino-2-carboxylatoethyl)disulfanyl]propanoate Chemical compound [Cu+2].[O-]C(=O)C(N)CSSCC(N)C([O-])=O QUQFTIVBFKLPCL-UHFFFAOYSA-L 0.000 description 1
- AZSFNUJOCKMOGB-UHFFFAOYSA-K cyclotriphosphate(3-) Chemical compound [O-]P1(=O)OP([O-])(=O)OP([O-])(=O)O1 AZSFNUJOCKMOGB-UHFFFAOYSA-K 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Natural products C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
- 239000001177 diphosphate Substances 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- IRXRGVFLQOSHOH-UHFFFAOYSA-L dipotassium;oxalate Chemical compound [K+].[K+].[O-]C(=O)C([O-])=O IRXRGVFLQOSHOH-UHFFFAOYSA-L 0.000 description 1
- TVQLLNFANZSCGY-UHFFFAOYSA-N disodium;dioxido(oxo)tin Chemical compound [Na+].[Na+].[O-][Sn]([O-])=O TVQLLNFANZSCGY-UHFFFAOYSA-N 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940005740 hexametaphosphate Drugs 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229960001774 octenidine Drugs 0.000 description 1
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 239000003605 opacifier Substances 0.000 description 1
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229920002432 poly(vinyl methyl ether) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229940084560 sanguinarine Drugs 0.000 description 1
- YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000013024 sodium fluoride Nutrition 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 229960000414 sodium fluoride Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229940079864 sodium stannate Drugs 0.000 description 1
- YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 159000000008 strontium salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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Abstract
本发明涉及包含作为主擦洗剂的颗粒碳酸钙的牙膏。通过使用较细颗粒碳酸钙和一定量的较粗颗粒碳酸钙的混合物,与只使用较细颗粒碳酸钙的牙膏相比,所述牙膏能提供一个降低的RDA值,同时保持相同的清洁率。
Description
本发明涉及含有存在于适当液状或糊状介质中的并且作为主擦洗剂的颗粒碳酸钙的牙膏。
颗粒碳酸钙在牙膏中是一种众所周知的擦洗剂,含有这种擦洗剂的牙膏已经面市几十年。各种类型和来源的颗粒碳酸钙已经被使用或建议,诸如颗粒天然碳酸钙,其实例为粉状石灰石、磨细大理石、白云石粉、磨细环层石(groud vaterite)、磨细霰石和研细白垩,以及合成的颗粒碳酸钙诸如沉淀碳酸钙。合成的颗粒碳酸钙比天然颗粒碳酸钙使用更普遍并通常作为优选。使用的各种颗粒碳酸钙的平均颗粒尺寸可在较宽的范围内变化,通常重量平均直径为40微米或40微米以下。
虽然碳酸钙对牙齿有良好的清洁作用,但作为擦洗剂的颗粒碳酸钙的缺点之一为:与其它擦洗剂诸如磷酸二钙和不溶性偏磷酸钠相比,它们更能磨损和破坏牙齿的釉质和牙质。人们也知道颗粒碳酸钙的磨损性随重量平均颗粒尺寸的增大而增大,这就是为什么使用范围为1-15微米的低重量平均颗粒尺寸的原因。
目前令人吃惊和出乎意料地发现:内含少量粗得多的颗粒碳酸钙的重量平均颗粒尺寸为15微米或15微米以下的颗粒碳酸钙能降低后者的磨损性,同时保持相同的清洁率。由此我们发现:75-92.5%(重量)的重量平均颗粒尺寸为15微米或15微米以下的颗粒碳酸钙(在下文被称为"细碳酸钙")与25-7.5%(重量)的重量平均颗粒尺寸为30微米或30微米以上的颗粒碳酸钙(在下文被称为"粗碳酸钙")的混合物与100%的重量平均颗粒尺寸为15微米或15微米以下的颗粒碳酸钙相比,具有相同的清洁率,但是磨损性降低。
粗碳酸钙的重量平均颗粒尺寸范围为30微米到120微米,优选50到100微米和尤其优选70到90微米。在整个颗粒碳酸钙混合物中的粗碳酸钙的含量是混合物的7.5-25%(重量),优选10-20%(重量)和尤其优选12.5-17.5%(重量)。
细碳酸钙的重量平均颗粒尺寸为1到15微米之间,优选2-10微米。在本发明所述牙膏中用作擦洗剂的细和粗的碳酸钙的总量为所述牙膏的25-60%(重量),优选35-50%(重量)。
所述粗粒和细粒碳酸钙中的各自来源不是天然的就是合成的。粗粒和细粒碳酸钙的混合物可通过对适当数量的每种物质的简单混合来得到;当它们为同一来源时,也可以将某一来源的颗粒碳酸钙分级成具有所需重量平均颗粒尺寸的两个部分,随后按所需比例混合这两个部分。当然,所述细和粗的碳酸钙也可以在后续生产中分别添加到所述牙膏中。
颗粒尺寸采用型号X版本1.2a的Malvern Mastersizer,使用说明书手册中列出的测量程序,使用检测体系中的300毫米的透镜进行测量。这里采用的参考规格为D50,这是指颗粒总量中50%(重量)比所述颗粒尺寸大和颗粒总量中50%(重量)比所述颗粒尺寸小。
本发明牙膏中含有的液状或糊状介质可能还包含任选的常用成分诸如可接受的药用载体如淀粉、蔗糖、水或水/醇体系等。少量的表面活性剂也可以包括在内,诸如阴离子、非离子、阳离子和两性表面活性剂。当按配方加入到所述牙膏中时,这种配方可能含有所有常用的牙膏成分。
因此,它可能包含其它的颗粒研磨物质诸如二氧化硅、氧化铝、磷酸二钙、焦磷酸钙、羟基磷灰石、三偏磷酸盐、不溶性六偏磷酸盐等,包括凝聚的颗粒研磨物质,数量少于碳酸钙的数量,研磨物质的总量不超过混合物的60%(重量)。
而且,所述牙膏可以包含润湿剂诸如甘油、山梨醇,丙二醇、木糖醇、乳糖醇等。
胶粘剂和增稠剂诸如羧甲基纤维素钠、黄原胶、***胶、增稠型二氧化硅等也可以包括在内。
香料诸如薄荷油和留兰香油也可以包括在内,防腐剂、遮光剂、着色剂、pH调节剂、脱臭剂、牙齿增白剂、过氧化漂白剂等也同样如此。过氧化漂白剂用的稳定剂诸如吡啶二羧酸或锡酸钠也可能有用而包括在内。而且,完全中和的聚丙烯酸盐也可以包括在内以提高碳酸钙和氟化物的相容性。
抗菌剂也可以包括在内,诸如三氯羟基二苯醚、洗必泰、铜-、锌-和亚锡盐诸如柠檬酸锌、柠檬酸锌钠和焦磷酸亚锡、血根碱提取物、2-甲基-5-硝基-1-咪唑基-乙醇。抗菌剂其它的实例为季铵化合物诸如十六烷基氯化吡啶鎓;双胍诸如二葡糖酸洗必泰、双辛氢啶、癸双辛胺啶、双胍啶;卤代双酚化合物诸如2,2′亚甲基双-(4-氯-6-溴酚)。
能提高活性组分传递的聚合化合物诸如抗菌剂也可以包括在内。这类聚合物的实施例为聚乙烯基甲基醚和顺丁烯二酸酐的共聚物和例如DE-A-3,942,643(高露洁)中所描述的那些其它类似的可提高传递的聚合物。
另外消炎剂诸如布洛芬、氟比洛芬、阿司匹林、消炎痛等也可以包括在内。
防龋剂诸如氟化钠、单氟磷酸钠、氟化亚锡、氟化胺,牙菌斑缓冲剂诸如尿素、乳酸钙、甘油磷酸钙、聚丙烯酸锶也可以包括在内。其它任选成分包括维生素诸如维生素C和植物提取液。脱敏剂诸如甘油单油酸酯、柠檬酸钾、氯化钾、酒石酸钾、碳酸氢钾、草酸钾、硝酸钾以及锶盐也可以包括在内。
缓冲牙膏pH和离子强度的缓冲剂和盐也可以包括在内,诸如正磷酸单钠或正磷酸三钠。也使用脂质体和其它包囊剂提高活性成分的传递或稳定性。
另外,所述牙膏可以包含抗结石剂诸如焦磷酸碱金属盐、含次磷酸的聚合物、有机膦酸酯、磷酸柠檬酸盐等。
此外,所述牙膏可以包含功能性生命分子诸如细菌素、抗体、酶等。
其它任选成分也可以包括在内例如漂白剂、例如EP-A-0,545,594中描述的那些、发泡体系诸如碳酸氢钠/柠檬酸体系、颜色改变体系等。
本发明牙膏可以按单独一个配方配制而成,或按不同配方在多个间隔容器中配制而成,例如一个含有碳酸钙以及与它相容的成分,另一个含有其余成分。
本发明将通过实施例作进一步说明。
实施例1
下面牙膏的相对牙质磨损值(RDA)是通过Grabenstetter及其他人在J.Dent.Res.37(1958)1060-1068页中所描述的相对牙质磨损法(RDA法)测量的。
这些糊状物的清洁力是通过Stookey在J.Dent.Res.61(11)(1982)1236-1239页中所描述的体外沾污模型法测量的。
所述牙膏具有以下组成:
得到以下结果:
组成 | A | B | C |
颗粒白垩(D50=8毫米) | 35 | 32.5 | 30 |
颗粒白垩(D50=76毫米) | 2.5 | 5 | |
正磷酸三钠 | 1 | 1 | 1 |
增稠型二氧化硅 | 2 | 2 | 2 |
山梨醇(70%) | 30 | 30 | 30 |
羧甲基纤维素钠 | 0.9 | 0.9 | 0.9 |
十二烷基硫酸钠 | 2.5 | 2.5 | 2.5 |
二氧化钛 | 0.5 | 0.5 | 0.5 |
*** | 0.075 | 0.075 | 0.075 |
糖精钠 | 0.22 | 0.22 | 0.22 |
香料 | 1.1 | 1.1 | 1.1 |
水 | 适量 | 适量 | 适量 |
A B C
RDA值 113 122 86
A与B之间,无显著差异;
A与C之间,有显著差异(P<0.05)
%清洁率(敲击750次后) 55 65 50
%清洁率(敲击1500次后) 55 70 55
A、B、C之间无显著差异。
这些结果表明产品C具有显著降低的RDA值并保持本发明牙膏的清洁效率。
Claims (8)
1.包括存在于液状或糊状介质中的并且作为主擦洗剂的颗粒碳酸钙的牙膏,其特征在于所述颗粒碳酸钙含有75-92.5%(重量)的重量平均颗粒尺寸为1微米到15微米之间的细粒碳酸钙混合物与7.5-25%(重量)的重量平均颗粒尺寸为30微米到120微米之间的粗粒碳酸钙混合物的混合物。
2.按照权利要求1的牙膏,其特征在于所述细粒碳酸钙的重量平均颗粒尺寸为2微米到10微米之间。
3.按照权利要求1或2的牙膏,其特征在于所述粗粒碳酸钙的重量平均颗粒尺寸为50微米到100微米之间。
4.按照权利要求1-3的牙膏,其特征在于所述粗粒碳酸钙的重量平均颗粒尺寸为70微米到90微米之间。
5.按照权利要求1-4的牙膏,其特征在于它含有10-20%(重量)的粗粒碳酸钙的混合物。
6.按照权利要求5的牙膏,其特征在于它含有12.5-17.5%(重量)的粗粒碳酸钙的混合物。
7.按照权利要求1-6的牙膏,其特征在于所述牙膏含有占所述牙膏重量的25%到60%的颗粒碳酸钙的混合物。
8.按照权利要求7的牙膏,其特征在于它含有占所述牙膏重量的35%到50%的颗粒碳酸钙的混合物。
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CN103476385A (zh) * | 2011-04-18 | 2013-12-25 | 荷兰联合利华有限公司 | 牙齿再矿化口腔护理组合物 |
CN103930089A (zh) * | 2011-09-23 | 2014-07-16 | 荷兰联合利华有限公司 | 口腔护理组合物 |
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CN1298310C (zh) * | 2001-10-02 | 2007-02-07 | 荷兰联合利华有限公司 | 含有精细研磨的天然白垩的口腔组合物 |
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AU2013389356B2 (en) * | 2013-05-13 | 2016-03-31 | Colgate-Palmolive Company | Oral care composition containing pumice and calcium carbonate |
MX2016007267A (es) * | 2013-12-11 | 2016-09-07 | Colgate Palmolive Co | Metodos para tratar la gingivitis usando pasta dental con un alto contenido de sal. |
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EP2921173A1 (en) | 2014-03-21 | 2015-09-23 | Omya International AG | Surface-reacted calcium carbonate for desensitizing teeth |
DE102015014073A1 (de) * | 2015-10-30 | 2017-05-04 | Black Forest Dental GbR (vertreten durch die Gesellschafter: Ralf Stempel, 79809 Weilheim, Jürgen Breinlinger, 5323 Rietheim) | Zahnputzmittel |
CN107280984B (zh) * | 2017-07-26 | 2020-08-25 | 广西满庭芳精细化工有限公司 | 一种口腔护理摩擦剂及其制备方法和应用 |
EP3733154A1 (en) | 2019-05-03 | 2020-11-04 | Omya International AG | Magnesium ion-containing materials as white pigments in oral care compositions |
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FR2625676B1 (fr) * | 1988-01-07 | 1994-03-04 | Pharmascience Laboratoires | Dentifrice a bon rapport pouvoir nettoyant/ pouvoir abrasif |
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- 1999-07-23 BR BRPI9913159-5A patent/BR9913159B1/pt not_active IP Right Cessation
- 1999-07-23 DE DE69917465T patent/DE69917465T2/de not_active Expired - Lifetime
- 1999-07-23 HU HU0301541A patent/HU229472B1/hu not_active IP Right Cessation
- 1999-07-23 ES ES99938351T patent/ES2220100T3/es not_active Expired - Lifetime
- 1999-07-23 WO PCT/EP1999/005362 patent/WO2000010520A1/en active IP Right Grant
- 1999-07-23 CN CNB998098914A patent/CN1155362C/zh not_active Expired - Fee Related
- 1999-07-23 PL PL346057A patent/PL197044B1/pl unknown
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103476385A (zh) * | 2011-04-18 | 2013-12-25 | 荷兰联合利华有限公司 | 牙齿再矿化口腔护理组合物 |
CN103476385B (zh) * | 2011-04-18 | 2015-12-09 | 荷兰联合利华有限公司 | 牙齿再矿化口腔护理组合物 |
CN103930089A (zh) * | 2011-09-23 | 2014-07-16 | 荷兰联合利华有限公司 | 口腔护理组合物 |
CN103930089B (zh) * | 2011-09-23 | 2016-03-16 | 荷兰联合利华有限公司 | 口腔护理组合物 |
Also Published As
Publication number | Publication date |
---|---|
HUP0301541A3 (en) | 2012-09-28 |
CA2338639A1 (en) | 2000-03-02 |
PL346057A1 (en) | 2002-01-14 |
BR9913159A (pt) | 2001-05-15 |
ATE267003T1 (de) | 2004-06-15 |
HU229472B1 (en) | 2014-01-28 |
ID28029A (id) | 2001-05-03 |
TR200100567T2 (tr) | 2001-06-21 |
EP1107725A1 (en) | 2001-06-20 |
EP1107725B1 (en) | 2004-05-19 |
BR9913159B1 (pt) | 2013-05-28 |
HUP0301541A2 (hu) | 2003-08-28 |
DE69917465T2 (de) | 2005-06-02 |
CN1155362C (zh) | 2004-06-30 |
MXPA01001977A (es) | 2005-07-25 |
ES2220100T3 (es) | 2004-12-01 |
AU5288399A (en) | 2000-03-14 |
WO2000010520A1 (en) | 2000-03-02 |
PL197044B1 (pl) | 2008-02-29 |
DE69917465D1 (de) | 2004-06-24 |
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