CN1293825C - 二氢杨梅树皮素在制备食品、化妆品或药品中的应用 - Google Patents
二氢杨梅树皮素在制备食品、化妆品或药品中的应用 Download PDFInfo
- Publication number
- CN1293825C CN1293825C CNB021346291A CN02134629A CN1293825C CN 1293825 C CN1293825 C CN 1293825C CN B021346291 A CNB021346291 A CN B021346291A CN 02134629 A CN02134629 A CN 02134629A CN 1293825 C CN1293825 C CN 1293825C
- Authority
- CN
- China
- Prior art keywords
- dihydromyricetin
- food
- application
- medicine
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KJXSIXMJHKAJOD-LSDHHAIUSA-N (+)-dihydromyricetin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC(O)=C(O)C(O)=C1 KJXSIXMJHKAJOD-LSDHHAIUSA-N 0.000 title claims abstract description 103
- KQILIWXGGKGKNX-UHFFFAOYSA-N dihydromyricetin Natural products OC1C(=C(Oc2cc(O)cc(O)c12)c3cc(O)c(O)c(O)c3)O KQILIWXGGKGKNX-UHFFFAOYSA-N 0.000 title claims abstract description 51
- 235000013305 food Nutrition 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title claims abstract description 11
- 239000002537 cosmetic Substances 0.000 title abstract description 11
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 230000003078 antioxidant effect Effects 0.000 claims description 11
- 239000003963 antioxidant agent Substances 0.000 claims description 7
- 150000003254 radicals Chemical class 0.000 claims description 6
- 230000002605 anti-dotal effect Effects 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 7
- 208000007848 Alcoholism Diseases 0.000 abstract description 4
- 201000007930 alcohol dependence Diseases 0.000 abstract description 4
- 230000003712 anti-aging effect Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 235000019261 food antioxidant Nutrition 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- BGNXCDMCOKJUMV-UHFFFAOYSA-N Tert-Butylhydroquinone Chemical compound CC(C)(C)C1=CC(O)=CC=C1O BGNXCDMCOKJUMV-UHFFFAOYSA-N 0.000 description 20
- 230000000694 effects Effects 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 239000004250 tert-Butylhydroquinone Substances 0.000 description 10
- 235000019281 tert-butylhydroquinone Nutrition 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 235000006708 antioxidants Nutrition 0.000 description 6
- 239000012043 crude product Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 description 4
- 239000000287 crude extract Substances 0.000 description 4
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 241000219099 Parthenocissus quinquefolia Species 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 229940112822 chewing gum Drugs 0.000 description 3
- 235000015218 chewing gum Nutrition 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 150000002978 peroxides Chemical class 0.000 description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- 244000246386 Mentha pulegium Species 0.000 description 2
- 235000016257 Mentha pulegium Nutrition 0.000 description 2
- 235000004357 Mentha x piperita Nutrition 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 235000006040 Prunus persica var persica Nutrition 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- 208000030303 breathing problems Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 235000001050 hortel pimenta Nutrition 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- DCYOADKBABEMIQ-OWMUPTOHSA-N myricitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=C(O)C=2)OC2=CC(O)=CC(O)=C2C1=O DCYOADKBABEMIQ-OWMUPTOHSA-N 0.000 description 2
- DCYOADKBABEMIQ-FLCVNNLFSA-N myricitrin Natural products O([C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)C1=C(c2cc(O)c(O)c(O)c2)Oc2c(c(O)cc(O)c2)C1=O DCYOADKBABEMIQ-FLCVNNLFSA-N 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 229910052573 porcelain Inorganic materials 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000010499 rapseed oil Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000015112 vegetable and seed oil Nutrition 0.000 description 2
- 239000008158 vegetable oil Substances 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- OTEKOJQFKOIXMU-UHFFFAOYSA-N 1,4-bis(trichloromethyl)benzene Chemical compound ClC(Cl)(Cl)C1=CC=C(C(Cl)(Cl)Cl)C=C1 OTEKOJQFKOIXMU-UHFFFAOYSA-N 0.000 description 1
- 241000563984 Ampelopsis Species 0.000 description 1
- 206010006458 Bronchitis chronic Diseases 0.000 description 1
- 241000238571 Cladocera Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241001628273 Moina macrocopa Species 0.000 description 1
- 208000018569 Respiratory Tract disease Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- -1 acyl radical Chemical class 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000031016 anaphase Effects 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 208000007451 chronic bronchitis Diseases 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000005021 gait Effects 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000003859 lipid peroxidation Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000020795 whole food diet Nutrition 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
处理 | 水蚤数(只) | 平均寿命(天) | 最高寿命(天) |
1 | 20 | 8.32 | 11 |
2 | 20 | 10.75 | 14 |
3 | 20 | 12.35 | 16 |
4 | 20 | 13.71 | 17 |
组别 | 小鼠 | 兴奋不安(%) | 步态不稳(%) | 呼吸加快(X±S) | 跌倒(X±SD) | 醒酒时间(X±S) |
1 | 20 | 0 | 0 | 0 | 0 | 0 |
2 | 20 | 75 | 95 | 100 | 75 | 103.6±45.00 |
3 | 20 | 100 | 70 | 100 | 20 | 45.65±16.5 |
4 | 20 | 95 | 60 | 100 | 15 | 30.00±10.37 |
例数 | 临床控制 | 显效 | 有效 | 无效 | 总有效率(%) | |
急性上感 | 20 | 14 | 3 | 3 | 0 | 100 |
急性咽炎 | 22 | 16 | 3 | 3 | 0 | 100 |
慢性咽炎 | 15 | 3 | 9 | 3 | 0 | 100 |
慢性支气管炎 | 13 | 1 | 8 | 4 | 0 | 100 |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021346291A CN1293825C (zh) | 2002-08-30 | 2002-08-30 | 二氢杨梅树皮素在制备食品、化妆品或药品中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB021346291A CN1293825C (zh) | 2002-08-30 | 2002-08-30 | 二氢杨梅树皮素在制备食品、化妆品或药品中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1399916A CN1399916A (zh) | 2003-03-05 |
CN1293825C true CN1293825C (zh) | 2007-01-10 |
Family
ID=4747820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021346291A Expired - Lifetime CN1293825C (zh) | 2002-08-30 | 2002-08-30 | 二氢杨梅树皮素在制备食品、化妆品或药品中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1293825C (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100389766C (zh) * | 2003-10-30 | 2008-05-28 | 湖南省中医药研究院 | 二氢杨梅素在制备药物中的应用 |
CN100356858C (zh) * | 2004-09-28 | 2007-12-26 | 广东省农业科学院蚕业与农产品加工研究所 | 一种天然果蔬及果蔬制品护色剂的用途 |
CN101485655B (zh) * | 2009-02-12 | 2012-08-22 | 华南理工大学 | 二氢杨梅素在制备防治肿瘤放化疗不良反应的药物的应用 |
EP2608786A2 (en) * | 2010-08-24 | 2013-07-03 | The Regents of the University of California | Methods of treating alcohol intoxication, alcohol use disorders and alcohol abuse which comprise the administration of dihydromyricetin |
CN106491582A (zh) * | 2015-09-06 | 2017-03-15 | 中国科学院上海生命科学研究院 | 含二氢杨梅素的抗醉制剂及其用途 |
CN105232350B (zh) * | 2015-11-05 | 2018-03-23 | 浙江中医药大学 | 水面膜及其制作方法 |
CN105902534B (zh) * | 2016-04-19 | 2019-06-14 | 梁京 | 苯酚茶酸素在制备治疗或预防呼吸***疾病药物中的应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63208506A (ja) * | 1987-02-24 | 1988-08-30 | Nonogawa Shoji:Kk | 化粧料 |
CN1288747A (zh) * | 1999-09-16 | 2001-03-28 | 宋新荣 | 含有二氢杨梅素的药物组合物 |
JP2002065201A (ja) * | 2000-08-24 | 2002-03-05 | Maruzen Pharmaceut Co Ltd | 色素の退色防止剤 |
JP2002159566A (ja) * | 2000-08-28 | 2002-06-04 | Maruzen Pharmaceut Co Ltd | 消臭剤及び抗菌剤 |
-
2002
- 2002-08-30 CN CNB021346291A patent/CN1293825C/zh not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS63208506A (ja) * | 1987-02-24 | 1988-08-30 | Nonogawa Shoji:Kk | 化粧料 |
CN1288747A (zh) * | 1999-09-16 | 2001-03-28 | 宋新荣 | 含有二氢杨梅素的药物组合物 |
JP2002065201A (ja) * | 2000-08-24 | 2002-03-05 | Maruzen Pharmaceut Co Ltd | 色素の退色防止剤 |
JP2002159566A (ja) * | 2000-08-28 | 2002-06-04 | Maruzen Pharmaceut Co Ltd | 消臭剤及び抗菌剤 |
Also Published As
Publication number | Publication date |
---|---|
CN1399916A (zh) | 2003-03-05 |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU ABADIE PHARMACEUTICAL BIOLOGY LTD. Free format text: FORMER OWNER: ZHANG YOUSHENG Effective date: 20030417 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20030417 Address after: Guangzhou Wanbao Industrial Park 511495 Panyu District Village Applicant after: Guangzhou Bio-technology Co.,Ltd. Address before: 510640 Guangdong city of Guangzhou province Tianhe District Wushan South China University of Technology Food College Applicant before: Zhang Yousheng |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 511495 Wanbao North Street, Panyu District, Guangzhou, Guangdong Province, No. 1 Patentee after: GUANGZHOU BAIYUSHAN BAIDI BIOTECHNOLOGY CO.,LTD. Address before: Wanbao Industrial Park, Panyu District bell village, Guangzhou Patentee before: Guangzhou Bio-technology Co.,Ltd. |
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CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20070110 |