CN1281271C - Biological bacteria inhibitor - Google Patents
Biological bacteria inhibitor Download PDFInfo
- Publication number
- CN1281271C CN1281271C CNB2004100244002A CN200410024400A CN1281271C CN 1281271 C CN1281271 C CN 1281271C CN B2004100244002 A CNB2004100244002 A CN B2004100244002A CN 200410024400 A CN200410024400 A CN 200410024400A CN 1281271 C CN1281271 C CN 1281271C
- Authority
- CN
- China
- Prior art keywords
- antibacterial
- chlorhexidine gluconate
- chlorhexidine digluconate
- polyglycopeptide
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The present invention discloses a biological bacterium inhibitor which contains chlorhexidine digluconate and polyglycopeptide. The bacteria inhibitor is added to water to be prepared into a cleaning solution usually, the concentration of the chlorhexidine digluconate in the cleaning solution is 0.01 to 0.1 g/ml, and the concentration of the polyglycopeptide in the cleaning solution is 0.01 to 0.05 g/ml. The bacterium inhibitor is used for inhibiting colibacillus, staphylococcus aureus and candida. The combination of chlorhexidine digluconate and polyglycopeptide promotes each other to generate obvious bioactivity, take admirable therapeutic effect, perform the function of inhibiting the bacterium activity of chlorhexidine digluconate, improve the peripheral blood cells simultaneously, enhance the phagocytic function of a net endothelial system, synthesize various proteins required by skin repair, and activate macrophage and lymphocyte.
Description
Technical field
The present invention relates to a kind of medicine, be specifically related to a kind of external antibacterial.
Background technology
Sterile products in the market, the overwhelming majority can only sterilize with antibacterial to skin surface, for the antibacterial that is hidden in the body surface deep layer, as escherichia coli, staphylococcus aureus, Candida albicans, gram negative bacteria and positive bacteria, be difficult to kill and suppress, therefore initial in treatment, although but it arrives certain sterilization, bacteriostasis efficacy to above-mentioned pathogenic bacteria, but because the body surface deep layer still has pathogenic bacteria to exist, therefore pathogenic bacteria can grow very soon; pathological changes should not be effected a radical cure, and the sterilization of antibacterial, disinfective action and effect are restricted.
Summary of the invention
In view of existing antibacterial above shortcomings, the invention provides a kind of sterilization, the significant antibacterial of bacteriostasis efficacy, this antibacterial combines conventional wide-spectrum bactericide with modern biotechnology, make antibacterial when killing the body surface pathogenic bacteria, may penetrate into the source of disease depths of body surface deep layer, killing pathogenic bacteria fundamentally, and the position of pathological changes repaired, make diseased region rapidly, thoroughly rehabilitation.
For solving the problems referred to above that existing antibacterial exists, the following technical proposals that the present invention adopts.
The invention discloses a kind of biological bacteriostatic agent, it is characterized in that, described antibacterial comprises chlorhexidine gluconate and polysaccharide peptide.
Chlorhexidine gluconate C
22H
30CL
2N
102C
6H
12O
7Be conventional antibacterial.Main inventive point of the present invention is to be about to chlorhexidine gluconate and polysaccharide peptide (Man)
n-(GlcNAc)
2-Asn-Ser (Thr) is used in combination by intermolecular, both produce significant biological activity each other in conjunction with impelling for this, produced splendid therapeutic effect, in performance chlorhexidine gluconate bacteriostatic activity, can promote peripheral blood cells, strengthen net endothelial system phagocytic function, the synthetic required various albumen of skin of repairing, activated macrophage and lymphocyte, induce the thymocyte cell lymphocyte to produce active substance, improve and enhancing human body function and emergency capability, have the effect of enhance immunity, antiviral, infection, rising human leukocytes.
But wherein polysaccharide peptide activated macrophage and lymphocyte, strengthen the resistivity of human body self, can make simultaneously chlorhexidine gluconate infiltrate the body surface deep layer, therefore increased the sterilization and the bacteriostatic function of chlorhexidine gluconate greatly, further, the polysaccharide peptide is a protein, diseased region had quick repair, therefore increased the immunologic function and the stress ability of diseased region greatly, can make and utterly destroy source of disease, made the quick rehabilitation of diseased region.
Among the present invention, as long as make chlorhexidine gluconate and polysaccharide peptide mix use mutually, the function that has promptly possessed sterilization and inhibition, activated macrophage and lymphocyte and reparation, antibacterial all can be in body surface and body surface deep layer sterilizations, antibacterial, and can make the quick rehabilitation of diseased region.
For making different patients be easier to use this antibacterial, this antibacterial is a washing liquid through the dilution post-treatment usually, is about to described antibacterial and adds and be configured to washing liquid in the entry.By in antibacterial, adding certain water, be mixed with the antibacterial washing liquid, antibacterial can be used as conventional medicine and uses, and can extensively promote socially.
In the preferred described antibacterial, the concentration of described chlorhexidine gluconate in washing liquid is 0.001～0.05g/ml, and the concentration of described polysaccharide peptide in washing liquid is 0.0005～0.04g/ml.Further preferred: the concentration of described chlorhexidine gluconate in washing liquid is 0.001～0.01g/ml, and the concentration of described polysaccharide peptide in washing liquid is 0.0005～0.01g/ml.
The antibacterial that contains 0.001～0.05g/ml chlorhexidine gluconate and 0.0005～0.04g/ml polysaccharide peptide aqueous solution is white or little yellow translucent liquid, have nontoxic, tasteless characteristics, reached 99%-100% in efficient antibacterial 2 minutes, non-stimulated to skin, mucosa, safe in utilization, effective and the escherichia coli of energy, Gram-positive and negative bacterium such as staphylococcus aureus also have the good restraining effect to funguses such as Candida albicans.
In the antibacterial, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 1: 0.1～10 in the described antibacterial.Preferably: the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 10: 1～50 in the described antibacterial.
This antibacterial is used to suppress escherichia coli, staphylococcus aureus, Candida albicans etc.
Wherein the genitals candidiasis is common is 20～30 years old women, the pregnant phase sickness rate that shakes can increase one times, 75% the women of child-bearing age had the vaginal candida medical history in life at least one time, wherein 45% women possibility repeated infection, oral contraceptive, diabetes, immunodeficiency etc. are all sick therewith relevant, and common having in 7 is sick, and Candida albicans wherein is maximum to human body harm, characteristic of disease is the strongest, and the candidiasis 85～90% that goes out from vaginal secretion is Candida albicans.The nontoxic Candida albicans suppression ratio of this biological bacteriostatic agent is 2 minutes 99.99～100%, therefore can treat above-mentioned disease fast, and suppress this palindromia.
This antibacterial merges Candida albicans urethritis etc. to erythema such as monilial vaginitis, vulvitis, cervical erosion, property balanoposthitis, glans penis and coronary sulcus, erosion, men and women's urethritis, male urethra condyloma acuminatum, unique bacteriostasis is all arranged, this product has special effect to infectious dermatosis, gynaecopathia, various sexually transmitted disease (STD), this lotion porous to the source of disease depths, engulf bacterium, repair skin, obviously suppressed, and do not have any pain in one minute.
Antibacterial among the present invention has bitterness, non-stimulated to skin, mucosa, mouth, eyes, to escherichia coli, Staphyloccocus aureus, have powerful fungistatic effect, can treat gynaecopathia, various urethritiss, vulvitis, cervical erosion, balanoposthitis, vulvitis, the cervical erosion inflammation, male urethra mouth condyloma acuminatum.This antibacterial can improve and strengthen human body function and emergency capability, has the effect of enhance immunity, antiviral, infection, rising human leukocytes.
Among the present invention, can add other secondary solvent or medicament in the antibacterial, be the effect of antibacterial among explanation the present invention, under for example:
Case 1, Lee XX man and wife two all catch monilial vaginitis, use the antibacterial lotion once, do not see recurrence.
Case 2, the ninth of the ten Heavenly Stems XX, the male, crissum is caught Candida albicans, with antibacterial once, does not see recurrence.
Case 3, an X, the women, 50 years old, the coli-infection senile vaginitis with the antibacterial lotion once, was not seen recurrence.
Case 4, Xiao X, the women, 25 years old, be trichomonal vaginitis through chemical examination, with the antibacterial lotion once, check behind the first quarter moon that assay is the symptom complete obiteration.
Case 5, king XX, the women suffers from pudendum eczema, and with antibacterial once, diagnostic result is the symptom complete obiteration after 10 days.
Case 6, king X, the male, infection of staphylococcus aureus, the crown and glans penis place redness of pudendum, erosion, sepage have greyish white dense sexual secretion, and the ulcer oozing of blood is arranged, and pruritus, anaerobic infection use antibacterial once, and recurrence is not seen in the symptom complete obiteration.
Case 7, the X of Soviet Union, the male be non-pouring urethritis after diagnosing, promptly removes painful urination with behind the antibacterial number minute, chemically examines transference cure after ten days.
Case 8, XX man and wife in the wrong are mycoplasma, chlamydia, trichomonacide after diagnosing, with antibacterial once, chemically examine after March, and mycoplasma, chlamydia, trichomonacide all do not have.
Case 9, Liu XX suffer from bacterial vaginosis, and with antibacterial once, transference cure was chemically examined transference cure after 10 days at that time.
The specific embodiment:
The specific embodiment 1
A kind of antibacterial, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 80: 1 in this antibacterial.
The X of Soviet Union, the male be non-pouring urethritis after diagnosing, promptly removes painful urination after spreading upon affected part number minute with this antibacterial, chemically examines transference cure after ten days.
The specific embodiment 2
A kind of antibacterial, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 1: 90 in this antibacterial.
King X, the male, the crown and glans penis place redness of pudendum, erosion, sepage have greyish white dense sexual secretion, and the ulcer oozing of blood is arranged, and pruritus, anaerobic infection use this antibacterial to spread upon the affected part once, and recurrence is not seen in the symptom complete obiteration.
The specific embodiment 3
A kind of antibacterial, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 1: 50 in this antibacterial.
Bending the XX man and wife, is mycoplasma, chlamydia, trichomonacide after diagnosing, spreads upon the affected part once with antibacterial, chemically examines after March, and mycoplasma, chlamydia, trichomonacide all do not have.
The specific embodiment 4
A kind of antibacterial, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 50: 1 in this antibacterial.
Lee XX, the women catches monilial vaginitis, uses the antibacterial agent once, does not see recurrence.
The specific embodiment 5
A kind of antibacterial, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 1: 0.8 in this antibacterial.
Hole X, the male, the crown and glans penis place redness of pudendum, erosion, sepage have greyish white dense sexual secretion, and the ulcer oozing of blood is arranged, and pruritus, anaerobic infection use this antibacterial to spread upon the affected part once, and recurrence is not seen in the symptom complete obiteration.
The specific embodiment 6
A kind of antibacterial, chlorhexidine gluconate in this antibacterial: polysaccharide peptide: the weight ratio of glycerol is 1: 20.
The ninth of the ten Heavenly Stems XX, the male, crissum is caught Candida albicans, with antibacterial once, does not see recurrence.
The specific embodiment 7
A kind of antibacterial, chlorhexidine gluconate in this antibacterial (g): polysaccharide peptide (G): the ratio of normal saline (ml) is 1: 0.5: 200.
Open X, the women, 50 years old, be diagnosed as senile vaginitis, with the antibacterial lotion once, do not see recurrence.
The specific embodiment 7
A kind of antibacterial, chlorhexidine gluconate in this antibacterial (g): polysaccharide peptide (g): the ratio of water (ml) is 0.5: 0.25: 100.
Xiao X, the women, 25 years old, be trichomonal vaginitis through chemical examination, with the antibacterial lotion once, check behind the first quarter moon that assay is the symptom complete obiteration.
The specific embodiment 8
A kind of antibacterial aqueous solution, a kind of antibacterial, chlorhexidine gluconate in this antibacterial (g): polysaccharide peptide (g): the ratio of water (ml) is 0.45: 0.25: 100.
King XX, the women suffers from pudendum eczema, and with antibacterial once, diagnostic result is the symptom complete obiteration after 10 days.
Claims (5)
1, a kind of biological bacteriostatic agent is characterized in that, described antibacterial is made up of chlorhexidine gluconate and polysaccharide peptide.
2, biological bacteriostatic agent according to claim 1 is characterized in that, described antibacterial adds and is configured to washing liquid in the entry.
3, biological bacteriostatic agent according to claim 2 is characterized in that, the concentration of described chlorhexidine gluconate in washing liquid is 0.001～0.01g/ml, and the concentration of described polysaccharide peptide in washing liquid is 0.0005～0.01g/ml.
4, biological bacteriostatic agent according to claim 1 is characterized in that, the weight ratio of chlorhexidine gluconate and polysaccharide peptide is 10: 1～50 in the described antibacterial.
5, any described biological bacteriostatic agent of claim is used for suppressing the purposes of the washing liquid of escherichia coli, staphylococcus aureus, Candida albicans in the claim 1～4 in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100244002A CN1281271C (en) | 2004-07-04 | 2004-07-04 | Biological bacteria inhibitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100244002A CN1281271C (en) | 2004-07-04 | 2004-07-04 | Biological bacteria inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1602955A CN1602955A (en) | 2005-04-06 |
| CN1281271C true CN1281271C (en) | 2006-10-25 |
Family
ID=34663479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100244002A Expired - Fee Related CN1281271C (en) | 2004-07-04 | 2004-07-04 | Biological bacteria inhibitor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1281271C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2612729C (en) * | 2005-07-01 | 2018-02-27 | Kane Biotech Inc. | Antimicrobial compositions for inhibiting growth and proliferation of a microbial biofilm on medical devices |
| CN107326738A (en) * | 2017-06-30 | 2017-11-07 | 广西点图包装有限公司 | Paper product antibacterial finish agent |
| CN114766516B (en) * | 2022-04-20 | 2023-06-16 | 四川大学 | Lipopeptide compound antibacterial agent applicable to trichoderma and penicillium on bone cultural relics, and preparation method and application thereof |
-
2004
- 2004-07-04 CN CNB2004100244002A patent/CN1281271C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1602955A (en) | 2005-04-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101725175B1 (en) | Antimicrobial composition | |
| RU2409368C2 (en) | Composition and method to control and maintain bacterial microflora and acidity of vagina | |
| CN108158995A (en) | A kind of gynaecology's anti-bacteria foaming agent containing chitosan and preparation method thereof | |
| US20120046556A1 (en) | Methods and Kits for Preventing the Spread of Sexually Transmitted Microorganisms | |
| CN107998461A (en) | A kind of sheath that is exclusively used in has the function of the soluble oil of composite antibacterial | |
| CN107952059A (en) | A kind of gynaecology's bacteriostatic gel and preparation method thereof | |
| CN1788568A (en) | Quick-effective iodine disinfectant and production method thereof | |
| CN108404111B (en) | A bacteriostatic and antiviral preparation containing semen Phaseoli vulgaris phytohemagglutinin as main ingredient | |
| CN1372974A (en) | Exterior-applied gel contaiing lysozyme as primary component and its preparing process | |
| CN1281271C (en) | Biological bacteria inhibitor | |
| CN104487054A (en) | Compositions and methods for enhancing the efficacy of contraceptive microbicides | |
| CN108926577A (en) | A kind of method that electric potential water is used for Wound antibiotic healing cleaning-nursing | |
| CN100592915C (en) | Ecological vagina cleaning bacteriostasis liquid | |
| CN106267158A (en) | A kind of wound healing and the gel of reparation cervical mucosa | |
| Banerjee et al. | Bees make medicine for mankind | |
| RU2390341C2 (en) | Method of conservative treatment of bladder leukoplakia (squamous metaplasia) | |
| CN100388949C (en) | Lysostaphin freeze dried powder used for preventing and treating cattle edometritis | |
| CN111632073A (en) | Antibacterial and anti-inflammatory female privates probiotic composition and preparation thereof | |
| CN1431012A (en) | Externally used Chinese herbal medicine for treating gynecology inflammation | |
| CN101249084B (en) | Disinfection composing prescription of preventability transmitted diseases | |
| CN1056774C (en) | Keyoulin sterilizing bactericide | |
| CN105997858A (en) | Natural protein substance compound lotion | |
| CN102552885A (en) | Piles and anus internal epithelium and rectum mucous epithelium cell anti-inflammation celltrex made of marine organisms | |
| CN1270752C (en) | Antiseptic and its processing method | |
| CN1528341A (en) | Povidone-iodine foamable composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANGHAI ZHONGSHENG PHARMACEUTICAL TECHNOLOGY CO., Free format text: FORMER OWNER: ZHONG HOULU Effective date: 20110624 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 563002 INSIDE OF ZUNYI JINLONGKUI BIOTECHNOLOGY DEVELOPMENT CO., LTD., NO. 79, GAOXIANG ROAD, HUICHUAN DISTRICT, ZUNYI CITY, GUIZHOU PROVINCE TO: 200137 ROOM 103, BUILDING 1, NO. 399, XINGNAN ROAD, PUDONG NEW DISTRICT, SHANGHAI |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20110624 Address after: 103 room 399, building /1, No. 200137 South Road, Shanghai, Pudong New Area Patentee after: Shanghai Zhongsheng Pharmaceutical Technology Co., Ltd. Address before: 563002, Zunyi Jinlong Biotechnology Development Co., Ltd., 79 alley Road, Zunyi, Guizhou, Huichuan District Patentee before: Zhong Houlu |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20061025 Termination date: 20100704 |