CN1276764C - 一种中药组合物在制备治疗缺铁性贫血药物中的应用 - Google Patents
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Abstract
Description
组别 | 剂量(g/kg) | WBC(×109个/L) | RBC(×1012个/L) | Hb(g/L) | Pt 骨(×109个/L) | 髓有核细胞数(×101个/股骨) |
正常对照组 | 等体积水 | 9.6±2.1 | 5.6±0.4 | 124.1±5.4 | 194.9±34.2 | 1012±384 |
CY模型组 | 等体积水 | 2.9±0.4△ | 6.4±0.3* | 118.0±3.8* | 97.2±9.3△ | 315±186△ |
CY+四物汤 | 10.0 | 6.1±1.1*** | 6.6±0.4* | 121.4±6.8* | 129.8±12.3*** | 767±272** |
CY+本发明颗粒 | 8.6 | 4.2±0.8*** | 6.7±0.3* | 119.3±6.4* | 139.5±14.5*** | 486±178* |
CY+本发明颗粒 | 17.2 | 5.2±1.1*** | 6.7±0.4* | 120.8±5.6* | 163.3±16.3*** | 734±209** |
CY+本发明颗粒 | 34.4 | 6.0±1.2*** | 6.9±0.2 | 123.1±4.5* | 172.0±22.5*** | 845±266** |
组别 | 剂量(g/kg) | 脾指数(g/100g) |
正常对照组 | 等体积水 | 0.487±0.167 |
CY模型组 | 等体积水 | 0.221±0.082△ |
CY+本发明颗粒 | 10.0 | 0.448±0.071*** |
CY+本发明颗粒 | 8.6 | 0.391±0.120** |
CY+本发明颗粒 | 17.2 | 0.427±0.082*** |
CY+本发明颗粒 | 34.4 | 0.455±0.057*** |
组别 | 剂量(g/kg) | 体重(g) | WBC(×109个/L) | RBC(×1012个/L) | Hb(g/L) | Pt(×109个/L) |
正常照组 | 等体积水 | 25.2+5.3 | 9.1+1.0 | 6.4±0.5 | 116.9±6.2 | 229.1±32.1 |
CO60模型组 | 等体积水 | 22.1±2.7△ | 5.1±0.5△ | 6.8±0.3 | 106.9±6.0△ | 183.4±16.1△ |
CO60+四物汤 | 10.0 | 25.2±1.6** | 6.3±0.4*** | 6.9±0.3 | 127.7±8.8*** | 205.8±26.4** |
CO60+本发明颗粒 | 17.22 | 5.8±2.3** | 7.2±0.6*** | 7.0±0.4 | 136.0±5.1*** | 209.3±18.1** |
CO60+本发明颗粒 | 34.4 | 26.7±2.5** | 7.4±0.6*** | 7.2±0.2 | 135.8±8.4*** | 225.2±24.8*** |
组别 | 例数 | 男/女 | 年龄(岁) | 症状积分(分) |
试验组 | 71 | 22/49 | 43.00±12.99 | 10.72±4.23 |
对照组 | 30 | 9/21 | 40.10±10.95 | 10.63±2.48 |
组别 | 例数 | 临床控制(%) | 显效(%) | 显效以上(%) | 有效(%) | 无效(%) | 总有效(%) |
试验组 | 71 | 2(2.8) | 19(26.76) | 21(29.58) | 40(56.34) | 10(14.08) | 61(85.92) |
对照组 | 30 | 2(6.67) | 2(6.67) | 16(53.33) | 10(33.33) | 20(66.67) |
组别 | 例数 | 治疗前症状总积分(分) | 治疗后症状总积分(分) |
试验组 | 71 | 10.72±4.32 | 5.11±3.28 |
对照组 | 30 | 10.63±2.48 | 6.70±2.88 |
试验组 | 对照组 | |||||||
治疗前 | 治疗后 | 治疗前 | 治疗后 | |||||
例 | X±SD | 例 | X±SD | 例 | X±SD | 例 | X±SD | |
头晕眼花 | 60 | 1.99±0.61 | 22/69 | 0.80±0.63 | 29 | 2.14±0.52 | 3.29 | 1.21±0.62 |
神疲乏力 | 69 | 2.00±0.62 | 16/69 | 0.91±0.61 | 29 | 1.93±0.37 | 4/29 | 1.21±0.62 |
少气懒言 | 53 | 1.83±0.64 | 20/53 | 0.76±0.67 | 22 | 1.68±0.48 | 4/22 | 1.09±0.68 |
纳少 | 44 | 1.52±0.70 | 19/44 | 0.67±0.64 | 20 | 1.30±0.47 | 7/20 | 0.67±0.66 |
失眠 | 40 | 1.53±0.78 | 10/40 | 0.79±0.61 | 23 | 1.43±0.51 | 9/23 | 0.78±0.74 |
心悸 | 38 | 1.61±0.75 | 17/38 | 0.71±0.69 | 18 | 1.43±0.62 | 4/18 | 0.83±0.51 |
自汗 | 11 | 1.55±0.52 | 5/11 | 0.50±0.67 | 8 | 1.13±0.35 | 4/8 | 0.63±0.74 |
面色苍白 | 45 | 1.60±0.65 | 14/45 | 0.84±0.71 | 16 | 1.50±0.63 | 4/16 | 1.12±0.60 |
手足麻木 | 28 | 1.57±0.50 | 9/28 | 0.69±0.54 | 10 | 1.60±0.52 | 2/10 | 1.13±0.58 |
*** | 28 | 1.82±0.72 | 6/28 | 1.14±0.85 | 11 | 1.64±0.50 | 3/11 | 0.81±0.60 |
试验组 | 对照组 | |||||||
例 | 治疗前 | 例 | 治疗后 | 例 | 治疗前 | 例 | 治疗后 | |
HB | 70 | 90.30±11.94 | 70 | 105.3±12.8 | 30 | 88.93±11.68 | 30 | 99.28±14.57 |
RBC | 36 | 3.266±0.41 | 36 | 3.68±0.46 | 15 | 3.27±0.66 | 15 | 4.51±0.47 |
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CN103381217B (zh) * | 2013-05-13 | 2015-12-09 | 深圳国源国药有限公司 | 一种六味补血胶囊及其质量控制方法与应用 |
CN104855938A (zh) * | 2015-04-29 | 2015-08-26 | 桐城市佳明农业发展有限公司 | 一种香菇鸡肉酱及其制备方法 |
CN105214003A (zh) * | 2015-11-10 | 2016-01-06 | 李玉宾 | 一种治疗贫血的药物组合物及其制备方法 |
CN106214823A (zh) * | 2016-08-10 | 2016-12-14 | 湖南敬和堂制药有限公司 | ***放化疗后毒副作用的中药组合物及其制备方法 |
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