CN103520253A - Medicine for treating strain and asthenic disease symptoms and preparation method thereof - Google Patents
Medicine for treating strain and asthenic disease symptoms and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a medicine for treating strain and asthenic disease symptoms, namely physical fatigue symptoms and a preparation method thereof. The medicine comprises effective components which are dogwood, epimedium herb, American ginseng and fermented cordyceps mycelia powder. The preparation method comprises the following steps: adding 8 times amount of 70% alcohol to the dogwood, the epimedium herb and the American ginseng which are cleaned, extracting by using a reflux extraction method to obtain an extract, filtering, combining, recycling alcohol from filtrate, concentrating the filtrate to clear paste, drying under reduced pressure, smashing, and fully and uniformly mixing the obtained paste powder and the fermented cordyceps mycelia powder; preparing the mixed powder into soft materials by using 85% alcohol, pelleting, drying, granulating and encapsulating, thus obtaining the finished product. The medicine has very good effects of tonifying qi and yin and nourishing liver and kidney and an obvious treatment effect on the strain and asthenic disease symptoms.
Description
Technical field
Content of the present invention belongs to the preparing technical field of pharmaceuticals, relates to a kind of medicine of deficient disease and preparation method thereof that strains that is used for the treatment of.
Background technology
Along with the quickening of modern society's rhythm of life, the pressure of people's work and life increases, and fatigue is just becoming " persistent ailment " that many moderns can't get rid of, and the thing followed is that people's health suffers damage silently, and passive protective physical fitness is also declining gradually.Fatigue is divided into acute fatigue and confirmed fatigue.What in the modern life, most people occurred is confirmed fatigue, its show as absent minded, lethargy is depressed, degradation under soreness of the waist and knees, loss of appetite, bradykinesia, deficiency of QI with disinclination to talk, forgetful, work or the learning efficiency, even has headache, dizzy, cardiopalmus, nervous, nauseating, thirsty, weak, asthenia, tired meaning, drowsiness, insomnia, the reaction such as impatient.Modern study thinks, chronic fatigue syndrome is that the operating pressure of the long-term accumulation of people can not get effectively alleviating and a kind of mental status with hazardness of causing.Investigation shows, the most easily the crowd in fatigue state is middle age, white collar, colleges and universities and student and teacher in secondary school, in addition, taxi driver, liked night life or also very easily tired through the people of the night work of being everlasting, though the many people in them can continue or continuous operation, but ability to work and efficiency obviously decline, its fatigue symptom also has more than by simple rest and can be eased.
Physical fatigue belongs to the category of the traditional Chinese medical science " overstrain ", " asthenia ", that is the deficient disease of straining.In in the past long-term medical practice, the ancient Chinese medicine doctor application Chinese medicine deficient disease class disease of straining has obtained a lot of successfully experiences.Due to Chinese medicine, there is the features such as curative effect is reliable, effect is comprehensive, clinical drug safety, thereby be deeply subject to vast " fatigue " patient's high praise.The known oral medicinal herb preparation that is used for the treatment of such disease has tens of kinds more than in the market, as east supernatural power capsule, OYSTER EXTRACT CAPSULE capsule, MAIWEIDIHUANGWAN, three-animal penes shake awake ball, Xueshen liquid for oral administration etc., but the cause and mechanism more complicated due to fatigue generation, existing medicine still also has certain limitation at aspects such as clinical efficacies, therefore, develop new medicine preparation evident in efficacy, lasting, that safety is good and still there is important practical value and scientific meaning.
Summary of the invention
The object of the invention is to the problem existing for prior art, the preparation method of a kind of prescription science, the medicine and this medicine that are used for the treatment of the deficient disease of straining that easy to prepare, therapeutic effect is good is provided.
The preparation scheme of medicine of the present invention is that designer obtains by concentrated summary development according to clinical practice for many years and on modern pharmacology experiment basis.Motherland's theory of medicine thinks, insufficiency of kidney-YANG, function of liver and spleen imbalance play a part quite main in tired Emergence and Development.Kidney storing essence and gate of vitality's fire (being kidney yin, kidney yang), main bone, raw marrow lead in brain, and it is cloudy that kidney essense belongs to, and each internal organs of human body are played to the nourishing effect that makes moist; Gate of vitality's fire i.e. " kidney yang ", and each internal organs of human body are played to warm and biochemical action, if insufficiency of kidney-YANG, limbs fatigue, is slow in action, deficient in energy.Liver storing blood, has the function of preserving and regulating blood; Liver is main muscle again, as the vital essence of liver the tendon being unable to move that declines; Liver is main catharsis also, has promoting flow of QI and blood, happy mechanism of qi, bar to reach the effect of emotion, as stagnation of QI due to depression of the liver causes taste, becomes estranged.The generation of confirmed fatigue is many due to long-term psychentonia, physical fatigue, cause the functional disorder of the yang blood and qi of internal organs, the transporting mistake department of the dysfunction of acting as a pivot of liver and gall, taste and the damp and hot retardance of three warmers etc., have influence on the catharsis of insufficiency of kidney-YANG, liver, and then cause hepatic and renal function imbalance.Therefore, nourishing the liver and kidney, supplementing QI and nourishing YIN, fully to regulate the function of liver, kidney be also the key for the treatment of alleviating physical fatigue.
The prescription of medicine of the present invention, just on above-mentioned etiology and pathogenesis understanding basis, take nourishing the liver and kidney, supplementing QI and nourishing YIN selects as principle for the treatment of, it is prepared scheme and selects the medicine materials such as Fructus Corni, Herba Epimedii, Radix Panacis Quinquefolii and fermented Cordyceps powder to form compound recipe, make multi-medicament reasonable compatibility, the effect of deficient disease class disease thereby common completed treatment strains.
For realizing the medicine that above goal of the invention develops, be a kind of capsule of being made by Fructus Corni, Herba Epimedii, Radix Panacis Quinquefolii and fermented Cordyceps powder four taste effective ingredient medicine materials, the weight proportion of each medicine material component is:
Fructus Corni 45～55, Herba Epimedii 36～44,
Radix Panacis Quinquefolii 27～33, fermented Cordyceps powder 18～22.
Technical program of the present invention also lies in, in capsule, the weight proportion of each taste effective ingredient medicine material component is:
Fructus Corni 50, Herba Epimedii 40,
Radix Panacis Quinquefolii 30, fermented Cordyceps powder 20.
Method for the preparation of this capsule comprises following processing step:
1, Fructus Corni, Herba Epimedii, the Radix Panacis Quinquefolii got after clean system are put into Chinese medicine extracting tank, adding 8 times of amount 70% ethanol adopts reflux extraction to extract 2 times, each 2 hours, extracting solution filters, merging filtrate (medicinal residues are abandoned), filtrate recycling ethanol under-0.65Mpa～-0.75Mpa, 65 ℃ of conditions, is condensed into by filtrate the clear paste that 60 ℃ of relative densities while surveying are 1.30～1.35, standby;
2, get above-mentioned alcohol extraction clear paste under-0.85Mpa condition in 65 ℃ of drying under reduced pressure, after pulverizing, cross 80 mesh sieves, gained cream powder and fermented Cordyceps powder fully mix; With 85% ethanol, make soft material, with 16 mesh sieves, granulate, 50 ℃～60 ℃ dry, and 14 mesh sieve granulate, mix, and pack capsule into No. 0, and every fills 0.4～0.5g, gets product.
The formula of medicine of the present invention be take Fructus Corni, Herba Epimedii, Radix Panacis Quinquefolii and fermented Cordyceps powder as primary raw material, and through extracting refining forming, in side, the use of each effective ingredient medicine material is according to as described below.
Fructus Corni is the drying and ripening sarcocarp of Cornaceae plant Fructus Corni.Sour in the mouth, puckery, slightly warm in nature.Return liver, kidney channel.Fructus Corni has the effect of liver and kidney tonifying, essence astringing and desertion stemming, is clinically used for the treatment of the diseases such as vertigo and tinnitus, soreness of waist and knee joint, impotence and seminal emission.Pharmacological research shows, gives mice drink-service Fructus Corni decoction pieces 6ml/kg, continuous 60 days, with borax method Measuring hemoglobin content, with swimming with a load attached to the body method, measure endurance, result shows that Fructus Corni can obviously improve the content of hemoglobin of mice, obviously strengthens mice muscular strength and anti-fatigue ability.
Herba Epimedii is the dry aerial parts of Berberidaceae plant Herba Epimedii.Acrid in the mouth, sweet, warm in nature.Return liver, kidney channel.Herba Epimedii is conventional Psoralen tonifying YANG Chinese medicine, has the effect of kidney-replenishing, strengthening bone and muscle, is clinically used for the treatment of the diseases such as impotence and seminal emission, muscles and bones flaccidity be soft.Research shows, Herba Epimedii compound recipe has the human body of raising function, strengthens immunocompetence, promotes androgen secretion, improves body anti-oxidation function, therefore has the effect that promotes recovery and allaying tiredness, raising motor capacity.Pharmacological research also shows, Herba Epimedii has slow down aging, resisting fatigue and anoxia enduring and promotes the effect etc. of protein synthesis and nucleic acid metabolism.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii.Sweet in the mouth, micro-hardship, cool in nature.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid, for the deficiency of vital energy cloudy lose, the tired disease such as tired of interior-heat, deficiency-heat.The effect of research Radix Panacis Quinquefolii to central nervous system, find that Radix Panacis Quinquefolii has the effect of resisting fatigue, enhancing immunity and hypoxia-bearing capability, can obviously extend mice swimming time and grab the rod time, life span and toleration while extending anoxia and during mouse brain hypoxic-ischemic are to improve motor capacity, promote to recover and a kind of effective preparation of allaying tiredness.Zoopery confirms that in Radix Panacis Quinquefolii, contained ginsenoside can improve body Ldh Activity, and the content of muscle glycogen and hepatic glycogen has the effect that can reduce Serum lactic acid content simultaneously.
Fermented Cordyceps powder be in fresh Cordyceps specimen the separated Clavicipitaceae fungus peacilomyce hepiahi bacterium strain Cs-4 bacterial strain obtaining through the mycelial dried powder of liquid submerged fermentation gained.Fermented Cordyceps powder is the artificial substituting product of Cordyceps, carrying out composition relative analysis result with Qinghai product high-quality natural cordyceps proves, this product and Cordyceps chemical composition are basically identical, and pharmacological action is also basic identical with Cordyceps, there is equally antifatigue effect, and safety non-toxic evil.Fermented Cordyceps powder can have the effect of resisting fatigue by strengthening the activity of lactic acid dehydrogenase (LDH), for body provides energy.
In sum, in the present invention formula the sweet acid of Fructus Corni moistening, mainly enter Liver and kidney, can benefit essence, again can be supporing yang, be longer than the astringent or styptic treatment for spontaneous sweating part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, be the key medicine of caused by liver and kidney deficiency, instability of kidney-QI; The sweet temperature of Herba Epimedii, kidney invigorating and YANG supporting, Xin Wen is expelling wind and removing dampness again, is the key medicine of impotence due to deficiency of the kidney; Radix Panacis Quinquefolii bitter cold is let out clearly, sweet cold and cool benefit, boosting qi and nourishing yin, is the product of cold benefit; Fermented Cordyceps powder is reinforcing the kidney and supporting YANG both, and beneficial intensive culture is cloudy again, is the key medicine of deficiency of the kidney void.Above four tastes share, supplementing QI and nourishing YIN, and nourishing the liver and kidney, fully regulates the function of liver, kidney, reaches the object that improves tired patients ' life quality.
In R&D process of the present invention, for this medicament capsule of objective appraisal is to the clinical effectiveness of resisting fatigue and the safety to human body, applicant carries out clinical research to the present invention, now observed result is summarized as follows:
1, clinical data:
The insufficiency of kidney-YANG of selector combination of syndromes example standard, fatigue patient's 60 examples of function of liver and spleen imbalance are divided into matched group and treatment group, respectively include 30 examples in for two groups, two groups all without the case that comes off, treatment group man 20 examples, female's 10 examples, 42～70 years old age, matched group man 17 examples, female's 13 examples, the age was at 43～67 years old, at aspects such as age, sexes, learn by statistics processing no significant difference, there is comparability for two groups.
2, Therapeutic Method
Treatment group is taken capsule for treating of the present invention, and each 2 every day three times, 30th is a course for the treatment of; Require patient to adhere to that dietary and appropriate body are fully taken exercise every day and avoid stress and overworked, before and after treatment, all do blood, glucose in urine, liver, the inspection of kidney merit, some patients were is done immunologic function test.Matched group is made as blank, does not take any anti-fatigue effect food and medicine.
3, curative effect judging standard
Main observation: disease is improved situation, each symptom all by without, light, in, carry out the labelling before medication heavily respectively;
Clinical effective: symptom disappears substantially or all; Clinical effectively: paresthesia epilepsy number of times, degree have obviously and alleviate; Invalid is that symptom is front basic identical with treatment.
4, safety treatment
The symptom of adverse events; The chemical examination of hematuria stool routine, hepatic and renal function, Electrocardioscopy.
5, two groups of disease efficacy analysis:
5.1, two groups of patients are at Clinical efficacy comparison: effective 11 examples for the treatment of group, effective 3 examples of matched group.The former is obviously better than the latter's (table 1) at curative effect.
Table 1 liang group patient Comparison of therapeutic
| Group | Effective | Effectively | Invalid | Effectively total |
| Treatment group | 11(37％) | 15(50％) | 4(13％) | 26(87％) |
| Matched group | 3(10％) | 10(33％) | 17(57％) | 13(43％) |
5.2, the statistical effect (table 2) to fatigue symptom
Table 2: treatment group symptom is improved situation analysis chart
This clinical research statistics shows: in effective process, patient's brains is salubrious, memory obviously improves, attention is concentrated; From head to foot energetically, energetic, full of vigour, appetite increases; Cardiopalmus, the ambition pain of feeling oppressed disappears; Transaminase is normal, and after capacity for liquor promotes to some extent, awakes from a drunken sleep, brain is clear-headed; Energy relieving cough and asthma, expectorant become clear and fewer and feweri, do not pant on foot upstairs; The transference cures such as body of gland retraction, secretions disappearance, frequent micturition, urgent micturition, dysurea.
6, the observation of safety:
In this clinical observation, treatment group and matched group are not all found any untoward reaction.The inspections such as blood, urine, stool routine and the liver that experiment case is done, renal function, electrocardiogram, are showed no any abnormal change, illustrate that medicine is safe at clinical application.
7, discuss:
Clinical treatment result of study shows: medicine of the present invention is to fatigue syndrome patient, disease sees that lassitude, fatigue and weak, dizziness and blurred vision, pale white complexion, drowsiness or insomnia, cardiopalmus are nervous, soreness of the waist and knees, the symptom such as forgetful have positive effect, before and after two groups of treatments, at aspects such as disease total effectses, treatment group curative effect is obviously better than simple Primary Care.
In clinical observation, find: two groups of patients all do not observe untoward reaction, each safety observation index no abnormality seen changes simultaneously.
The specific embodiment
Embodiment
The prescription total amount of a kind of capsule embodiment of the present invention is 1400g, and production technology mainly contains two parts, 1.. fermented Cordyceps powder is directly used as medicine; 2.. alcohol reflux (Fructus Corni, Herba Epimedii, Radix Panacis Quinquefolii).Its selection process demonstration test step is: take Fructus Corni 50g, Herba Epimedii 40g, Radix Panacis Quinquefolii 30g after the clean system of 1/10 recipe quantity, amount to 120g, parallel three parts, according to the process conditions of screening, above-mentioned 3 herbal medicines are inserted in HTN-0.5 type Chinese medicinal pot, the 70% alcohol reflux secondary that adds 8 times of amounts (9600g), each 2 hours, extracting solution adopts plate filter (filter material specification: 200 order stainless steel meshs) filter, merging filtrate, medicinal residues, precipitate and other solid impurity discard, filtrate is inserted in HWZ-100 type Chinese medicine concentrating tank, adopt the concentrated unit of Chinese medicine extraction filtrate recycling ethanol under-0.65Mpa～-0.75Mpa, 65 ℃ of conditions, and filtrate is condensed into the clear paste that relative density is 1.30～1.35 (60 ℃ of surveys), standby, getting above-mentioned alcohol extraction clear paste proceeds to drip pan and puts to HLK-2 type vacuum drying oven again, adjust temperature to 65 ℃, vacuum-0.85Mpa, carry out drying under reduced pressure (oven dry), dry the starting stage, every 2 hours, open dehumidifying valve dehumidifying once, 8～10 minutes time, drying course once turns over after approximately 5 hours and falls to coil, afterwards every 6 hours dehumidifying once, until dry (whole drying course approximately needs 15～20 hours), with FY-320 type high speed disintegrator by broken rear mistake 80 mesh sieves of dried cream powder, fermented Cordyceps powder 20g is added in above-mentioned bar cream powder, mix, with 85% ethanol, making hands pinches agglomerating, rub loose soft material, with 16 mesh sieves, granulate, with drip pan, be connected into the wet grain that uniform thickness is 3～5cm, put into CT-C-1 type heated-air circulation oven, 50 ℃～60 ℃ of constant temperatures, air blast, dehumidifying is dry, dried granule is crossed 14 mesh sieves, with CH-200 trough type mixing machine, mix 30 minutes, guarantee that mixing of materials is even, obtain semi-finished product granule, by semi-finished product granule with packing capsule into No. 0 after the polishing of YPJ-II type capsule polisher, every dress 0.5g, get product.
Claims (2)
1. a medicine for the treatment of the deficient disease of strain, is characterized in that it is the capsule of being made by the effective ingredient medicine material of following weight proportioning:
Fructus Corni 45～55, Herba Epimedii 36～44,
Radix Panacis Quinquefolii 27～33, fermented Cordyceps powder 18～22;
Method for the preparation of this medicine comprises following processing step:
1.1 Fructus Corni, Herba Epimedii, the Radix Panacis Quinquefoliis of getting after clean system are put into Chinese medicine extracting tank, adding 8 times of amount 70% ethanol adopts reflux extraction to extract 2 times, each 2 hours, extracting solution filters, merging filtrate, filtrate recycling ethanol under-0.65Mpa～-0.75Mpa, 65 ℃ of conditions, is condensed into by filtrate the clear paste that 60 ℃ of relative densities while surveying are 1.30～1.35, standby;
1.2 get above-mentioned alcohol extraction clear paste under-0.85Mpa condition in 65 ℃ of drying under reduced pressure, after pulverizing, cross 80 mesh sieves, gained cream powder and fermented Cordyceps powder fully mix; With 85% ethanol, make soft material, with 16 mesh sieves, granulate, 50 ℃～60 ℃ dry, and 14 mesh sieve granulate, mix, and pack capsule into No. 0, and every fills 0.4～0.5g, gets product.
2. the treatment according to claim 1 medicine of deficient disease that strains, is characterized in that it is the capsule of being made by the effective ingredient medicine material of following weight proportioning:
Fructus Corni 50, Herba Epimedii 40,
Radix Panacis Quinquefolii 30, fermented Cordyceps powder 20.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107259551A (en) * | 2017-06-20 | 2017-10-20 | 苏州市李良济健康产业有限公司 | A kind of preparation method for the health products for improving muscle power |
| CN108478620A (en) * | 2018-06-05 | 2018-09-04 | 江西安顺堂生物科技有限公司 | It is a kind of to have benefiting essence-blood, nourishing and strengthening Yin and Yang, anti-aging, health products that are antifatigue, improving sexual performance |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107259551A (en) * | 2017-06-20 | 2017-10-20 | 苏州市李良济健康产业有限公司 | A kind of preparation method for the health products for improving muscle power |
| CN108478620A (en) * | 2018-06-05 | 2018-09-04 | 江西安顺堂生物科技有限公司 | It is a kind of to have benefiting essence-blood, nourishing and strengthening Yin and Yang, anti-aging, health products that are antifatigue, improving sexual performance |
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Application publication date: 20140122 |