CN1244797A - 氟代醚组合物和抑制路易斯酸存在下其降解的方法 - Google Patents
氟代醚组合物和抑制路易斯酸存在下其降解的方法 Download PDFInfo
- Publication number
- CN1244797A CN1244797A CN98802053A CN98802053A CN1244797A CN 1244797 A CN1244797 A CN 1244797A CN 98802053 A CN98802053 A CN 98802053A CN 98802053 A CN98802053 A CN 98802053A CN 1244797 A CN1244797 A CN 1244797A
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- CN
- China
- Prior art keywords
- sevoflurane
- lewis acid
- water
- fluoroether
- degradation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Catalysts (AREA)
Abstract
Description
1 | 2 | 3 | |
A | 50mg Al2O320ppm水 | 50mg Al2O3100ppm水 | 50mg Al2O3260ppm水 |
B | 20mg Al2O320ppm水 | 20mg Al2O3100ppm水 | 20mg Al2O3260ppm水 |
C | 10mg Al2O320ppm水 | 10mg Al2O3100ppm水 | 10mg Al2O3260ppm水 |
样品 | 计算的总湿度(ppm) | pH | HFIP(ppm) | 除HFIP外的总降解物(ppm) |
对照,瓶 | 6.0 | 6 | 57 | |
对照,安瓿1,RT | 3.0 | 7 | 50 | |
对照,安瓿2,RT | 4.0 | 6 | 51 | |
A装置(振荡过夜) | ||||
1 | 109 | 0 | 1.525 | 201614 |
2 | 206 | 0 | 2.456 | 105518 |
3 | 303 | 0 | 4.027 | 127134 |
4 | 595 | 5.0 | 7 | 82 |
5 | 951 | 5.0 | 12 | 84 |
B装置(不振荡) | ||||
1 | 109 | 0 | 1.936 | 195364 |
2 | 206 | 0 | 3.390 | 170869 |
3 | 303 | 0 | 5.269 | 101845 |
4 | 595 | 6.0 | 21 | 107 |
5 | 951 | 6.0 | 10 | 63 |
样品 | 总湿度 | pH | HFIP(ppm) | 总降解物(ppm) |
示踪水,60℃,144小时 | ||||
1 | 109 | 0 | 850 | 474796 |
2 | 206 | 3.5 | 78 | 4865 |
3-1 | 303 | 3.5 | 1316 | 6868 |
3-2 | 303 | 5.0 | 8 | 60 |
4 | 595 | 5.5 | 7 | 66 |
5-1 | 951 | 5.5 | 4 | 52 |
5-2 | 951 | 5.5 | 5 | 60 |
示踪水,40℃,200小时 | ||||
6-1 | 不加水 | 0 | 232 | 102435 |
6-2 | 不加水 | 2.5 | 24 | 68 |
7 | 109 | 3.0 | 40 | 77 |
8 | 206 | 5.0 | 7 | 59 |
9 | 303 | 5.0 | 6 | 59 |
10 | 595 | 6.0 | 6 | 60 |
11 | 951 | 6.0 | 5 | 60 |
降解产物(ppm) | |||
瓶号 | HFIP | P2 | 总量 |
1 | 124 | <10 | 185 |
2 | 84 | <10 | 123 |
3 | 77 | <10 | 137 |
4 | 56 | <10 | 89 |
5 | 144 | <10 | 190 |
6 | 63 | <10 | 96 |
7 | 58 | <10 | 95 |
8 | 60 | <10 | 102 |
9 | 51 | <10 | 106 |
10 | 65 | <10 | 140 |
降解产物(ppm) | |||
瓶号 | HFIP | P2 | 总量 |
1 | 1026 | 7938 | 14243 |
2 | 912 | 3013 | 6428 |
3 | 1160 | 4662 | 10474 |
4 | 908 | 3117 | 7381 |
5 | 907 | 6687 | 11774 |
6 | 1128 | 5448 | 11313 |
7 | 1152 | 2371 | 6695 |
8 | 1199 | 2925 | 7386 |
9 | 1560 | 4183 | 10325 |
10 | 1455 | 2255 | 6667 |
降解产物(ppm) | ||||||
HFIP | P2 | 总降解物 | ||||
时间 | 0小时 | 18小时 | 0小时 | 18小时 | 0小时 | 18小时 |
对照组(20ppm水) | ||||||
2 | <10 | 777 | <10 | 2291 | <50 | 5995 |
3 | <10 | 790 | <10 | 2714 | <50 | 6552 |
5 | 11 | 688 | <10 | 2446 | <50 | 5485 |
7 | <10 | 894 | <10 | 1171 | <50 | 4124 |
8 | <10 | 824 | <10 | 1950 | <50 | 5139 |
研究组(400ppm水) | ||||||
1 | 12 | 605 | <10 | <10 | <50 | 669 |
4 | <10 | 84 | <10 | <10 | <50 | 98 |
6 | <10 | 331 | <10 | <10 | <50 | 357 |
9 | <10 | 294 | <10 | <10 | <50 | 315 |
10 | 10 | 528 | <10 | <10 | <50 | 577 |
降解产物(ppm) | ||||||
HFIP | P2 | 总降解物 | ||||
时间 | 36小时 | 178小时 | 36小时 | 178小时 | 36小时 | 178小时 |
研究组(400ppm水) | ||||||
1 | <10 | 16 | <10 | <10 | <50 | <50 |
4 | <10 | <10 | <10 | <10 | <50 | <50 |
6 | <10 | 28 | <10 | <10 | <50 | <50 |
9 | <10 | 15 | <10 | <10 | <50 | <50 |
10 | <10 | 19 | <10 | <10 | <50 | <50 |
Claims (12)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/789,679 US5990176A (en) | 1997-01-27 | 1997-01-27 | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
US08/789,679 | 1997-01-27 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100368062A Division CN1321958C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1244797A true CN1244797A (zh) | 2000-02-16 |
CN1152674C CN1152674C (zh) | 2004-06-09 |
Family
ID=25148366
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2006101016375A Pending CN1899271A (zh) | 1997-01-27 | 1998-01-23 | 储存七氟烷的方法以及防止七氟烷被路易斯酸降解的方法 |
CNB98802053XA Expired - Lifetime CN1152674C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
CNB2004100368062A Expired - Lifetime CN1321958C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2006101016375A Pending CN1899271A (zh) | 1997-01-27 | 1998-01-23 | 储存七氟烷的方法以及防止七氟烷被路易斯酸降解的方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100368062A Expired - Lifetime CN1321958C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
Country Status (28)
Country | Link |
---|---|
US (6) | US5990176A (zh) |
EP (2) | EP0967975B1 (zh) |
JP (5) | JP3183520B2 (zh) |
KR (1) | KR100368672B1 (zh) |
CN (3) | CN1899271A (zh) |
AR (2) | AR011090A1 (zh) |
AT (2) | ATE320798T1 (zh) |
AU (1) | AU726733B2 (zh) |
BG (2) | BG65414B1 (zh) |
BR (1) | BR9806996A (zh) |
CA (2) | CA2626424A1 (zh) |
CO (1) | CO4920220A1 (zh) |
CZ (1) | CZ297092B6 (zh) |
DE (2) | DE69800928T2 (zh) |
DK (2) | DK1114641T3 (zh) |
ES (2) | ES2256104T3 (zh) |
GR (1) | GR3036190T3 (zh) |
HK (1) | HK1074434A1 (zh) |
HU (1) | HUP0002101A3 (zh) |
IL (1) | IL130150A (zh) |
NO (1) | NO993606L (zh) |
NZ (1) | NZ335994A (zh) |
PL (1) | PL334477A1 (zh) |
PT (2) | PT967975E (zh) |
SK (1) | SK284243B6 (zh) |
TR (1) | TR199901579T2 (zh) |
WO (1) | WO1998032430A1 (zh) |
ZA (1) | ZA98418B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102631335A (zh) * | 2005-04-18 | 2012-08-15 | 皮拉莫危急护理有限公司 | 含水量可忽略的七氟烷的制备方法 |
CN105106182A (zh) * | 2015-09-21 | 2015-12-02 | 山东新时代药业有限公司 | 七氟烷吸入剂 |
CN105193774A (zh) * | 2015-09-21 | 2015-12-30 | 山东新时代药业有限公司 | 一种七氟烷吸入剂 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990176A (en) * | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
US20030200963A1 (en) * | 1998-01-09 | 2003-10-30 | Flament-Garcia Mary Jane | Container for an inhalation anesthetic |
US6074668A (en) * | 1998-01-09 | 2000-06-13 | Abbott Laboratories | Container for an inhalation anesthetic |
US6162443A (en) * | 1998-01-09 | 2000-12-19 | Abbott Laboratories | Container for an inhalation anesthetic |
US7097849B2 (en) * | 1998-08-19 | 2006-08-29 | Jagotec Ag | Injectable aqueous dispersions of propofol |
EP1439677B9 (en) | 1999-01-08 | 2007-11-07 | Sony Deutschland GmbH | Synchronisation symbol structure for an OFDM system |
TW523409B (en) | 2000-09-15 | 2003-03-11 | Baxter Int | Container for inhalation anesthetic |
ES2289524T3 (es) * | 2003-09-10 | 2008-02-01 | Cristalia Produtos Quimicos Farmaceuticos Ltda. | Composicion farmaceutica estable de un compuesto de fluoroeter para uso anestesico, procedimiento para estabilizar un compuesto de fluoroeter, uso de un agente estabilizador para evitar la degradacion de un compuesto de fluoroeter. |
BR0303489A (pt) * | 2003-09-10 | 2005-07-05 | Cristalia Prod Quimicos Farm | Composição farmacêutica estabilizada de composto flúor-éter e método para inibir a degradação de composto flúor-éter. uso de agente estabilizante para inibir a degradação de composto flúor éter |
WO2009049460A1 (fr) * | 2007-10-15 | 2009-04-23 | Jiangsu Hengrui Medicine Co., Ltd. | Nouveau matériau conditionné de sévoflurane |
DK2244737T3 (da) * | 2008-01-22 | 2019-07-08 | Univ Texas | Flygtige anæstetiske sammensætninger omfattende ekstraktionsopløsningsmidler til regional anæstesi og/eller smertelindring |
US20090275785A1 (en) | 2008-05-01 | 2009-11-05 | Barry Jones | Distillation Method For The Purification Of Sevoflurane And The Maintenance Of Certain Equipment That May Be Used In The Distillation Process |
US8563115B2 (en) | 2008-08-12 | 2013-10-22 | Xerox Corporation | Protective coatings for solid inkjet applications |
US8092822B2 (en) * | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
US8283643B2 (en) * | 2008-11-24 | 2012-10-09 | Cymer, Inc. | Systems and methods for drive laser beam delivery in an EUV light source |
US8191992B2 (en) * | 2008-12-15 | 2012-06-05 | Xerox Corporation | Protective coatings for solid inkjet applications |
US9278048B2 (en) * | 2009-05-06 | 2016-03-08 | Baxter International, Inc. | Pharmaceutical product and method of use |
US9102604B1 (en) | 2010-02-15 | 2015-08-11 | Baxter International Inc. | Methods for cleaning distilling columns |
CA2952552C (en) * | 2016-11-02 | 2018-05-15 | Central Glass Company, Limited | Method for washing sevoflurane storage container and method for storing sevoflurane |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2992276A (en) * | 1959-05-20 | 1961-07-11 | Du Pont | Process for preparing polyfluoro alkyl compounds |
US3527813A (en) * | 1966-10-03 | 1970-09-08 | Air Reduction | 1,1,2 - trifluoro - 2 - chloroethyl difluoromethyl ether and its method of preparation |
US3689571A (en) * | 1970-07-31 | 1972-09-05 | Baxter Laboratories Inc | Fluorinated ether |
GB1499818A (en) * | 1974-12-06 | 1978-02-01 | Ici Ltd | Anaesthetic composition |
US4469898A (en) * | 1979-12-26 | 1984-09-04 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
JP2786108B2 (ja) * | 1994-03-31 | 1998-08-13 | セントラル硝子株式会社 | フルオロメチル−1,1,1,3,3,3−ヘキサフルオロイソプロピルエーテルの精製方法 |
IT1270239B (it) * | 1994-06-17 | 1997-04-29 | Zambon Spa | Composizione farmaceutica solida contenente acido (s)-2-(4- isobutilfenil) propionico come principio attivo |
US5990176A (en) * | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
-
1997
- 1997-01-27 US US08/789,679 patent/US5990176A/en not_active Expired - Lifetime
-
1998
- 1998-01-19 ZA ZA98418A patent/ZA98418B/xx unknown
- 1998-01-23 AU AU59300/98A patent/AU726733B2/en not_active Expired
- 1998-01-23 CZ CZ0256199A patent/CZ297092B6/cs not_active IP Right Cessation
- 1998-01-23 CA CA002626424A patent/CA2626424A1/en not_active Abandoned
- 1998-01-23 DE DE69800928T patent/DE69800928T2/de not_active Revoked
- 1998-01-23 NZ NZ335994A patent/NZ335994A/xx not_active IP Right Cessation
- 1998-01-23 EP EP98902707A patent/EP0967975B1/en not_active Revoked
- 1998-01-23 CO CO98003122A patent/CO4920220A1/es unknown
- 1998-01-23 PT PT98902707T patent/PT967975E/pt unknown
- 1998-01-23 CN CNA2006101016375A patent/CN1899271A/zh active Pending
- 1998-01-23 ES ES01107733T patent/ES2256104T3/es not_active Expired - Lifetime
- 1998-01-23 PT PT01107733T patent/PT1114641E/pt unknown
- 1998-01-23 AT AT01107733T patent/ATE320798T1/de active
- 1998-01-23 DK DK01107733T patent/DK1114641T3/da active
- 1998-01-23 EP EP01107733A patent/EP1114641B1/en not_active Expired - Lifetime
- 1998-01-23 BR BR9806996-9A patent/BR9806996A/pt active IP Right Grant
- 1998-01-23 HU HU0002101A patent/HUP0002101A3/hu unknown
- 1998-01-23 DK DK98902707T patent/DK0967975T3/da active
- 1998-01-23 ES ES98902707T patent/ES2170474T3/es not_active Expired - Lifetime
- 1998-01-23 AT AT98902707T patent/ATE201987T1/de not_active IP Right Cessation
- 1998-01-23 CN CNB98802053XA patent/CN1152674C/zh not_active Expired - Lifetime
- 1998-01-23 JP JP53216898A patent/JP3183520B2/ja not_active Expired - Lifetime
- 1998-01-23 WO PCT/US1998/001376 patent/WO1998032430A1/en active Application Filing
- 1998-01-23 IL IL13015098A patent/IL130150A/en not_active IP Right Cessation
- 1998-01-23 CN CNB2004100368062A patent/CN1321958C/zh not_active Expired - Lifetime
- 1998-01-23 PL PL98334477A patent/PL334477A1/xx not_active IP Right Cessation
- 1998-01-23 KR KR10-1999-7006724A patent/KR100368672B1/ko not_active IP Right Cessation
- 1998-01-23 SK SK861-99A patent/SK284243B6/sk not_active IP Right Cessation
- 1998-01-23 DE DE69833884T patent/DE69833884T2/de not_active Expired - Lifetime
- 1998-01-23 TR TR1999/01579T patent/TR199901579T2/xx unknown
- 1998-01-23 CA CA002278133A patent/CA2278133C/en not_active Expired - Lifetime
- 1998-01-26 AR ARP980100336A patent/AR011090A1/es active IP Right Grant
-
1999
- 1999-07-23 NO NO19993606A patent/NO993606L/no not_active Application Discontinuation
- 1999-08-10 BG BG103656A patent/BG65414B1/bg unknown
- 1999-08-10 BG BG109751A patent/BG109751A/bg unknown
- 1999-11-23 US US09/447,853 patent/US6288127B1/en not_active Expired - Lifetime
-
2000
- 2000-11-16 JP JP2000349024A patent/JP3664648B2/ja not_active Expired - Lifetime
-
2001
- 2001-07-06 GR GR20010401038T patent/GR3036190T3/el not_active IP Right Cessation
- 2001-08-08 US US09/924,573 patent/US6444859B2/en not_active Expired - Lifetime
-
2002
- 2002-07-03 US US10/190,271 patent/US6677492B2/en not_active Expired - Lifetime
-
2003
- 2003-06-26 US US10/606,821 patent/US20040048932A1/en not_active Abandoned
-
2005
- 2005-04-06 JP JP2005109476A patent/JP2005279283A/ja not_active Ceased
- 2005-06-29 HK HK05105456A patent/HK1074434A1/xx not_active IP Right Cessation
- 2005-12-27 JP JP2005374621A patent/JP2006143742A/ja not_active Ceased
- 2005-12-27 JP JP2005374622A patent/JP2006137769A/ja not_active Ceased
-
2006
- 2006-02-27 US US11/362,954 patent/US20060148906A1/en not_active Abandoned
- 2006-11-16 AR ARP060105042A patent/AR057610A2/es unknown
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102631335A (zh) * | 2005-04-18 | 2012-08-15 | 皮拉莫危急护理有限公司 | 含水量可忽略的七氟烷的制备方法 |
CN101180250B (zh) * | 2005-04-18 | 2013-05-22 | 皮拉莫危急护理有限公司 | 含水量可忽略的七氟烷的制备方法 |
CN105106182A (zh) * | 2015-09-21 | 2015-12-02 | 山东新时代药业有限公司 | 七氟烷吸入剂 |
CN105193774A (zh) * | 2015-09-21 | 2015-12-30 | 山东新时代药业有限公司 | 一种七氟烷吸入剂 |
CN105106182B (zh) * | 2015-09-21 | 2017-12-29 | 山东新时代药业有限公司 | 七氟烷吸入剂 |
CN105193774B (zh) * | 2015-09-21 | 2018-01-16 | 山东新时代药业有限公司 | 一种七氟烷吸入剂 |
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