CN1228068C - Medicated liquor for dispelling wind, removing alampness and relieving pain, and preparation process thereof - Google Patents
Medicated liquor for dispelling wind, removing alampness and relieving pain, and preparation process thereof Download PDFInfo
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Abstract
The present invention provides medicated liquor with the effects of wind elimination, dehumidification and acesodyne and a preparation method thereof. The medicinal materials of the medicated liquor comprises black-tail snake, paniculate swallowwort root, periploca forrestii schlechter and wintersweet root or wintersweet stem, and the medicated liquor is prepared by soaking and extracting the medicinal materials with edible wine; the content of paeonol (C9H10O3) from the paniculate swallowwort root in each 100 ml of the medicated liquor is higher than 1.7 mg in the measurement in an HPLC method. The medicated liquor has a reasonable formula on the basis of the medicine of Miao Nationality. The present invention adopts a modern preparative technique and modern analysis means for providing the medicated liquor with the effects of wind elimination, dehumidification and acesodyne and the advantages of convenient taking, conspicuous curative effect and safety.
Description
Technical field:
The present invention relates to field of traditional Chinese, be specifically related to a kind of have dispel the wind, the medicated wine and the preparation method of dehumidifying, analgesic effect.
Background technology:
Joint disease and traumatic injury are a kind of commonly encountered diseases and frequently-occurring disease, and Miao ethnic group uses Miao Ethnomedicine to treat this disease many distinctive features, receives effect preferably, compare with similar medicine on the market more reliable, and free of toxic effects.
Summary of the invention:
Technical problem to be solved by this invention is a reasonable formula on traditional Miao Ethnomedicine basis, adopts modern technology of preparing and analysis means, a kind of taking convenience is provided, evident in efficacy, safe dispels the wind, dehumidifying, Antalgica wine.
Disclosed by the invention have dispel the wind, the medicated wine of dehumidifying, analgesic effect is to be medical material with Zaocys, Radix Cynanchi Paniculati, Heiguteng exract and Radix Chimonanthi praecocis, with edible steeping in wine bubble, to extract the back formulated, every 100ml contains Radix Cynanchi Paniculati with paeonol (C with HPLC method mensuration
9H
10O
3) count greater than 1.7mg.
The weight ratio of wherein said medical material is: Zaocys: Radix Cynanchi Paniculati: Heiguteng exract: Radix Chimonanthi praecocis=(20～40): (1～5): (1～5): (1～5).
The number of degrees of described edible wine are 40～65 degree.
Another technical problem to be solved by this invention is the preparation method that discloses above-mentioned medicated wine.
The preparation of medicated wine disclosed by the invention comprises the steps:
(1) pretreatment
Get Radix Cynanchi Paniculati, Radix Chimonanthi praecocis, Heiguteng exract crude drug, through selection, wash quickly is washed, drying, and it is standby to make clean medical material; Other gets Zaocys, and the tail of decaptitating is removed internal organs, cleans, and cutting is standby;
(2) medicated wine preparation
1, the preparation of Serpentis wine: get the processing Zaocys by proportioning, add the airtight immersion of 7～10 times of 40～65 degree Chinese liquor 2 months, stir every day 1 time, get supernatant, filter, promptly get Serpentis wine;
2, the preparation of medicated wine: get the clean medical material of Heiguteng exract, Radix Chimonanthi praecocis, Radix Cynanchi Paniculati 3 flavors by proportioning, with 100～120 times of 40～65 degree Chinese liquor reflux, extract, 2 hours, then together with in the medical material impouring container, airtight leaving standstill 2 days got supernatant, and filtration promptly gets medicated wine;
3, preparation: Serpentis wine and medicated wine are merged, and mixing adds the correctives stirring and makes dissolving, adds Chinese liquor and is made into desired concn, and mixing left standstill 24 hours, filters, and fill, promptly.
A technical problem more to be solved by this invention be disclose that above-mentioned medicated wine dispels the wind in preparation, the application in the dehumidifying, analgesic drug product.
Medicated wine of the present invention can be used for treating rheumatic arthralgia, lumbar muscle strain, numbness contracture, apoplexy, deviation of the eye and mouth.
Seedling the doctor think, diseases such as anemofrigid-damp arthralgia and psoas muscle pain, bones and muscles pain, rheumatic arthritis are because infringement human bodies such as pathogenic wind toxic, severe pathogenic cold, noxious water, thus positions such as muscle, muscles and bones, joint, waist lower limb produce pain, expand stiff, numb, weight person's activities adverse, it is limited to work.Because of noxious water, severe pathogenic cold invasion and attack cause human body, thrombosis, blood trouble must be felt frustrated, and feeling frustrated must blood trouble.Lumbar muscle strain Seedling doctor claim " earsalgia " because of gravity choose lift due to wound cause.The former is impaired because of malicious heresy causes in the body, and causes Seedling doctor alleged " hindering to bright " (interior damage); The latter refers to external force damage human body, causes " hinder and give just " (wound).According to the theoretical pattern of Seedling medicine " guiding principle, warp, disease, disease ", above-mentioned disease belongs to cold disease, when controlling it with the medicine of a warm nature.
Claim in the Shennong's Herbal that Radix Cynanchi Paniculati is " main ghost hundred essences, diseases due to noxious agents produced by various parasites epidemic, evil gas, pyrexial malaria; Obey intrepid making light of one's life by commiting suicide for a long time "; " Mingyi Bielu " called it and " prolonged life with QI invigorating for a long time ", " SHENGCAO is wanted fully ": " infusing drugs in wine removes rheumatism ", " simple and easy medical herbs ": " controlling traumatic injury, bones and muscles pain "; " Guizhou side's medicine among the people collection ": " restoring menstrual flow and invigorating blood circulation " had relatively effectively perfect summary to the major function of Radix Cynanchi Paniculati: wind-expelling pain-stopping, removing toxic substances and promoting subsidence of swelling, promoting the flow of QI in the collateral by warming the meridian, dispelling the wind and dampness pathogens osteodynia, treating swelling and pain by traumatic injury.
Heiguteng exract, Compendium of Material Medica claim " the dispelling the wind and dampness pathogens multiple abscess is gone into usefulness in the wine, " " book on Chinese herbal medicine converge with speech ": " medicine of the rheumatism numbness of loosing also, can relaxing muscles and tendons to promote blood circulation, bonesetting, sharp marrow so syndrome caused by wind pathogen is more weak unable, is obeyed informal dress for a long time, makes outstanding contributions greatly ".
Radix Chimonanthi praecocis dispels the wind and regulates the flow of vital energy, promoting blood circulation and detoxication.The dispelling the wind and dampness pathogens arthralgia pain, traumatic injury, " Guizhou side's medicine among the people collection ": " controlling sore waist and aching in the waist and the back ", " Kweiyang traditional herbal medicine ": " dispelling the wind and dampness pathogens osteodynia, abdominal pain due to stagnation of QI ".
Theoretical according to Seedling medicine, Zaocys is hot in nature in the present invention's prescription, and it is sweet to distinguish the flavor of, and belongs to the medicine of a warm nature, goes into cold warp, dispels the wind, and collateral dredging is separated disease, is principal agent.Radix Cynanchi Paniculati, hot in nature, the fragrant fiber crops of flavor belong to the medicine of a warm nature, go into cold warp, have the removing dampness of dispeling the wind, the promoting of the circulation of QI and removing the obstruction in the collaterals function.Heiguteng exract, hot in nature, acrid in the mouth belongs to the medicine of a warm nature, goes into cold warp, the meridian dredging, wind-damp dispelling, promoting blood circulation and detumescence; Radix Chimonanthi praecocis, hot in nature, acrid in the mouth belongs to the medicine of a warm nature, goes into cold warp, dispels the wind and regulates the flow of vital energy, promoting blood circulation and stopping pain; Three medicines are accessory drugs altogether.Above-mentioned major-minor medicine compatibility is played altogether and is dispeled the wind, collateral dredging, the merit of pain relieving.
In the medicated wine of the present invention prescription, Radix Cynanchi Paniculati is got the merit of its wind-expelling pain-stopping, all wind-expelling pain-stopping class medicines such as Radix Clematidis, Ramulus Mori, Herba Aristolochiae Mollissimae etc. all alternative it; Heiguteng exract is got the merit of the meridian dredging, wind-damp dispelling, anti inflammatory blood quickening, therewith the similar Caulis Piperis Kadsurae of medicine, Rhizoma Polygoni Cuspidati etc. all alternative it; Radix Chimonanthi praecocis get dispel the wind regulate the flow of vital energy, the merit of promoting blood circulation and detoxication, similar therewith Rhizoma Curcumae Longae, Caulis Spatholobi etc. all alternative it.
Carry out the relevant toxicity and the test of pesticide effectiveness with medicated wine of the present invention:
One, toxicological test:
1, acute toxicity test
Get 20 of mices, water is can't help in fasting (16 hours), irritate stomach medicated wine solution of the present invention (after alcohol is removed in volatilization in the water-bath, adding distil water is diluted to the suspension that every ml is equivalent to original liquid 20ml), irritating the stomach amount is the 0.5ml/10g body weight, put under the room temperature and observed 7 days, tried mice and all survive, the no abnormality seen reaction.Other gets 20 mices, repeated trials, and the result is the same.
Calculate by the maximum stomach volume (0.5ml/10g body weight) of irritating of maximum concentration (every ml is equivalent to original liquid 20ml) and mice, maximum tolerated dose is 1000ml/kg, be equivalent to clinical recommended drug amount (30ml/ time, Bid) 833 times.
2, long term toxicity test
Medicated wine solution water-bath Back stroke of the present invention is sent out after drinking, thin up is that every ml is equivalent to original liquid 10ml, 5ml, to rat 50ml/kg/ day, 100ml/kg/ day, gavage 90 days continuously, do not see that the toxicity variation of outward appearance, body weight gain, hemogram, liver, renal function and the heart, liver, spleen, lung, five kinds of organs and tissues of kidney appears in animal.
Above-mentioned toxicity test shows, medicated wine safety non-toxic of the present invention.
Two, the test of pesticide effectiveness:
1, anti-inflammation detumescence experiment
(1) to the influence of adjuvant-induced arthritis: select 40 of body weight 160 ± 10g healthy rats for use, male and female half and half, be divided into 4 groups, the 1st～3 group gavages medicated wine of the present invention (give birth to imperial wind dispelling liquid) 100ml/kg, 50ml/kg respectively and with 25% alcoholic solution of volume, irritating the stomach amount is the 1ml/100g body weight, every day 1 time, per 4 groups of lumbar injection hydrocortisone 12.5mg/kg, Bid, successive administration 21 days.The 3rd day right back sufficient sole of the foot intradermal injection Freund ' s of the portion Freund's complete adjuvant of every Mus 0.05 causes inflammation at (containing bacillus calmette-guerin vaccine 3.6mg/ml) after administration.Cause scorching back 18h with the volumetric method measurement, 14d, 17d, 21d foot sole of the foot volume once, is the swelling degree with the parapodum sole of the foot in the difference of the volume that causes scorching front and back, and observe each Mus ear erythema, situation appears in afterbody tuberosity etc., weigh weekly once, continue after the drug withdrawal to observe 3 days, put to death animal and dissection, take by weighing thymus, spleen, the adrenal gland, the result shows, gives birth to imperial wind dispelling liquid and can suppress arthritic constitutional of Freund ' s Freund's complete adjuvant and Secondary cases pathological changes (seeing Table 1), compares with the blank group, significant difference and highly significant, administration group and hydrocortisone group rat ear erythema, infringements such as afterbody lesser tubercle all alleviate than matched group is obvious, do not see that the animal ingestion amount obviously reduces, body weight does not have significant change, and putting to death precontract is about 280g.The gross anatomy no abnormality seen shows no obvious abnormalities thymus, adrenal gland's weight.
Table 1 is given birth to the influence of imperial wind dispelling liquid to rat assist agent arthritis
Group dosage N
Cause scorching back different time swelling value (mlX ± S.D)
18h 14d 17d 21d
Cause scorching sufficient matched group 10 1.21 ± 0.41 1.98 ± 0.22 2.01 ± 0.51 2.64 ± 1.63
(right side) high dose group 100ml/kg 10 0.37 ± 0.26
*1.01 ± 0.28
*1.20 ± 0.36
*1.18 ± 0.81
*
Low dose group 50ml/kg 10 1.06 ± 0.44 1.25 ± 0.36
*1.24 ± 0.41
*1.20 ± 0.94
*
Hydrocortisone group 12.5mg/kg 10 0.66 ± 0.31
*0.54 ± 0.35
*0.98 ± 0.28
*0.81 ± 0.67
*
To parapodum matched group 10 0.41 ± 0.15 0.53 ± 0.20 0.66 ± 0.16
(left side) high dose group 10 0.12 ± 0.21
*0.14 ± 0.18
*0.31 ± 0.24
*
Low dose group 10 0.11 ± 0.26
*0.13 ± 0.21
*0.36 ± 0.28
*
Hydrocortisone group 10 0.08 ± 0.14
*0.11 ± 0.20
*0.14 ± 0.26
*
T check: compare with matched group
*Expression P＜0.05;
*Expression P＜0.01
(2) xylol causes the influence of mice auricle swelling: get 40 of 18～20g male and female, half and half mices, be divided into 4 groups at random, press table 2 gastric infusion every day, matched group is given and is waited capacity 25% ethanol liquid, and irritating the stomach amount is continuous 7 days of 0.2ml/10g body weight.After the last administration 30 minutes, each group all is applied to two sides, ear front and back, a mice left side with dimethylbenzene, every 0.03ml after 15 minutes, puts to death mice, lay round auricle with diameter 7mm card punch at the same position of mice two ears, analyse balance very much with 1/10 and weigh, as the swelling degree, the results are shown in Table 2 with the difference of every Mus left and right sides auricle weight, as seen high dose group and matched group relatively have significant difference (P＜0.05), show that this medicine xylol causes mice auricle swelling obvious inhibitory action is arranged.
Table 2 xylol causes the influence of mice auricle swelling
Group N dosage swelling degree (mg) (the P value of X ± SD)
Matched group 10 5.48 ± 2.47
High dose group 10 200ml/kg 2.85 ± 2.07＜0.05
Low dose group 10 100ml/kg 4.26 ± 2.69
Sodium salicylate group 10 0.5g/kg 2.69 ± 1.47＜0.05
(3) on Carrageenan causes the influence of rat paw edema: select 40 of body weight 180～220g healthy rats for use, be divided into 4 groups at random, press table 3 gastric infusion every day, matched group is given and is waited capacity 25% ethanol liquid, and continuous 7 days irritate the stomach amount is the 1ml/100g body weight.After the last administration 30 minutes, it is subcutaneous that 1% carrageenin only is expelled to the right back sufficient sole of the foot of rat middle part by 0.1ml/, cause scorching afterwards 1h, 3h, 4h and measure the right back sufficient pawl Zhou Jing of rat respectively, gained week footpath value is deducted before the administration week value directly, get all footpaths difference, knot is looked into and is seen Table 3, as seen high dose group is 3 to 4 hours, low dose group was at 4 hours, with matched group significance or significant differences (P＜0.05 are arranged relatively, P＜0.01), shows that rat paw edema has obvious inhibitory action due to this medicine on Carrageenan.
Table 3 on Carrageenan causes the influence of rat paw edema
Group N dosage
The all footpaths of rat foot claw difference (mm) (X ± SD)
1h 2h 3h 4h
Matched group 10 5.00 ± 1.61 11.7 ± 2.33 14.8 ± 1.99 16.1 ± 1.76
High dose group 10 100mg/kg 4.00 ± 1.73 9.6 ± 3.69 11.8 ± 2.71
*12.43 ± 2.87
*
Low dose group 10 50mg/kg 4.60 ± 1.20 10.2 ± 3.57 12.7 ± 2.76 13.0 ± 3.49
*
Sodium salicylate group 10 0.5g/kg 5.00 ± 1.34 7.5 ± 3.26
*9.7 ± 2.53
*12.6 ± 4.32
*
T check: compare with matched group
*Expression P＜0.05;
*Expression P＜0.01
(4) to the influence of capillary permeability: get 40 of body weight 20～22g mices, be divided into 4 groups at random, except that positive controls, press table 4 gastric infusion every day, matched group is given and is waited capacity 25% ethanol liquid, irritated the stomach amount in continuous 7 days and be the 0.2ml/10g body weight, the positive is organized in the 7th day lumbar injection 0.025% prednisone solution.Each organizes after the last administration 1 hour, the tail vein injects the blue normal saline solution 0.1ml/10g of 0.5% ivens body weight, lumbar injection 0.6% acetic acid normal saline solution 0.2ml/ only then, put to death after 20 minutes, cut off the abdominal cavity, with 4ml normal saline flushing abdominal cavity 2 times, merge washing liquid, adding normal saline again, to make total amount be 10ml, centrifugal 10 minutes in 3000 rev/mins, get supernatant, with 72 type spectrophotometers amount of dye (representing) in every mouse peritoneal washing liquid of 590nm wavelength place's colorimetric determination with the optical density value that dyestuff appears, knot is looked into and is seen Table 4, visible height, low dose group and matched group compare, and all there were significant differences (P＜0.05) shows that this medicine has the effect of the capillary permeability of inhibition.
The influence of table 4 pair vascular permeability
Group N dosage appears amount of dye (the P value of X ± SD)
Matched group 10 0.75 ± 0.51
High dose group 10 200ml/kg 0.24 ± 0.13＜0.05
Low dose group 10 100ml/kg 0.25 ± 0.08＜0.05
Positive group 10 5mg/kg 0.21 ± 0.20＜0.01
2, analgesic test
(1) Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction: 40 of the mices of getting body weight 18～20g male and female half and half, be divided into 4 groups at random, press table 5 gastric infusion every day, continuous 7 days, matched group give to wait capacity 25% ethanol liquid, irritates the stomach amount and is the 0.2ml/10g body weight, after the last administration 30 minutes, lumbar injection 0.6% acetic acid 0.2ml/ only observes every mice and turned round the body number of times in 15 minutes.The results are shown in Table 5, visible high and low dose group and matched group relatively have significance and significant differences (P＜0.05, P＜0.01) to show that this medicine Dichlorodiphenyl Acetate induced mice writhing response has obvious inhibitory action.
Table 5 Dichlorodiphenyl Acetate causes the influence of mouse writhing reaction
Group N dosage appears amount of dye (the P value of X ± SD)
Matched group 10 28.2 ± 5.11
High dose group 10 200ml/kg 18.4 ± 4.61＜0.01
Low dose group 10 100ml/kg 21.1 ± 5.56＜0.05
Sodium salicylate group 10 5mg/kg 18.8 ± 3.09＜0.01
(2) to the influence of thermostimulation pain: the female mice of getting body weight 18～20g, put on 55 ± 0.5 ℃ the water bath with thermostatic control metallic plate, measure normal pain threshold earlier, select in 30 seconds 40 of responsive Mus for use, be divided into 4 groups at random, press table 6 gastric infusion every day, continuous 7 days, matched group was given and is waited capacity 25% ethanol liquid, irritates the stomach amount and is the 0.2ml/10g body weight, after the last administration 30 minutes, measure each mice pain threshold.The results are shown in Table 6, visible high and low dose group and matched group relatively have significant difference (P＜0.01, P＜0.05),, show that this medicine has an obvious inhibitory action to thermostimulation is pain caused.
Group N dosage
The pain response time (X ± SD)
Last administration before the administration
30 minutes 60 minutes 90 minutes
Matched group 10 21.3 ± 4.6 24.5 ± 5.4 25.1 ± 7.8 28.5 ± 10.7
High dose group 10 200ml/kg 21.8 ± 7.3 31.4 ± 8.5
*51.3 ± 10.8
*50.6 ± 11.1
*
Low dose group 10 100ml/kg 20.3 ± 5.6 29.6 ± 6.7
*32.7 ± 11.3
*34.6 ± 10.2
*
Sodium salicylate group 10 5mg/kg 21.5 ± 6.5 31.8 ± 4.1
*55.9 ± 9.2
*56.8 ± 12.3
*
T check: compare with matched group
*Expression P＜0.05;
*Expression P＜0.01
Above-mentioned result of the test shows that medicated wine of the present invention has the obvious suppression effect to adjuvant-induced arthritis, and inflammatory swelling has the obvious suppression effect due to xylol and the carrageenin, and chemical pain and thermostimulation pain are all had significant analgesia role.Show that this medicine has antiinflammatory, detumescence, analgesic pharmacological action.
Carry out 30 routine clinical observations with medicated wine of the present invention, symptom is cured improvement rate and reached 90%, and is wherein especially particularly remarkable to the migratory arthralgia in the Chinese medical discrimination, damp arthralgia, arthralgia aggravated by cold, pyretic arthralgia effect, general to paralysis and rheumatoid arthritis effect; Better effects is recovered normally to have to erythrocyte sedimentation rate, anti-" O " in treatment back, and rheumatoid factor is turned out cloudy and reactive protein also has certain effect.Untoward reaction takes place in none example of clinical 30 routine application results, illustrates that this product has no side effect.Medicated wine of the present invention is to treat the effective medicine of rheumatism clinically, is worthy of popularization.
The specific embodiment:
Embodiment 1,
Congratulate * *, the woman, 58 years old, because of double knee joint, ankle joint pain 10+ is " rheumatic arthritis " at how tame hospital diagnosis, takes pathogenic wind expelling and blood circulation promoting collateral dredging Chinese medicine for a long time, informal dress Bu Luofen, ibuprofen pain relieving during arthralgia at ordinary times, the back is 3.0～3.5 * 103/L because of taking said medicine to leukopenia for a long time.The patient begins to take June 30 in 1997 and gives birth to imperial wind dispelling liquid, each 20ml, and every day three times, and chafe the place with this liquid.Through obviously alleviating with one week back pain, continue to take that pain disappears after 20 days, recur again.
Embodiment 2,
Prescription:
Radix Cynanchi Paniculati 2g
Heiguteng exract 3g
Radix Chimonanthi praecocis 2g
Zaocys 100g
Sucrose 50g
50 degree Chinese liquor 1000g
A, pretreatment
Get Radix Cynanchi Paniculati, Radix Chimonanthi praecocis, Heiguteng exract crude drug, through selection, wash quickly is washed, drying, and it is standby to make clean medical material; Other gets Zaocys, and the tail of decaptitating is removed internal organs, cleans, and cutting is standby;
B, medicated wine preparation
1, the preparation of Serpentis wine: get and handle Zaocys 100g, add the airtight immersion of 700g50 degree Chinese liquor 2 months, stir every day 1 time, get supernatant, filter, promptly get Serpentis wine;
2, the preparation of medicated wine: get the clean medical material of Heiguteng exract, Radix Chimonanthi praecocis, Radix Cynanchi Paniculati 3 flavors by proportioning, with 300g50 degree Chinese liquor reflux, extract, 2 hours, then together with in the medical material impouring container, airtight leaving standstill 2 days got supernatant, filters, and promptly gets medicated wine;
3, preparation: Serpentis wine and medicated wine are merged, and mixing adds sucrose 50g stirring and makes dissolving, adds Chinese liquor and is made into 1000ml, and mixing left standstill 24 hours, filters, and fill, promptly.Paeonol content is 0.017mg/ml.
Embodiment 3,
Prescription:
Radix Cynanchi Paniculati 5g
Heiguteng exract 4g
Radix Chimonanthi praecocis 3g
Zaocys 100g
Sucrose 50g
65 degree Chinese liquor 1000g
Preparation method is with embodiment 2, and the medicated wine paeonol content is 0.03mg/ml.
Claims (4)
1, a kind of have dispel the wind, the medicated wine of dehumidifying, analgesic effect, it is characterized in that this medicated wine is is medical material with Zaocys, Radix Cynanchi Paniculati, Heiguteng exract and Radix Chimonanthi praecocis, with edible steeping in wine bubble, to extract the back formulated, every 100ml with HPLC method mensuration contain Radix Cynanchi Paniculati in paeonol greater than 1.7mg; Wherein the weight ratio of each medical material is: Zaocys: Radix Cynanchi Paniculati: Heiguteng exract: Radix Chimonanthi praecocis=20～40: 1～5: 1～5: 1～5.
2, a kind of medicated wine as claimed in claim 1, the number of degrees that it is characterized in that wherein said edible wine are 40～65 degree.
3, a kind of preparation method of medicated wine as claimed in claim 1 is characterized in that the preparation of this medicated wine comprises the steps:
A, pretreatment
Get Radix Cynanchi Paniculati, Radix Chimonanthi praecocis, Heiguteng exract crude drug, through selection, wash quickly is washed, drying, and it is standby to make clean medical material; Other gets Zaocys, and the tail of decaptitating is removed internal organs, cleans, and cutting is standby;
B, medicated wine preparation
1) preparation of Serpentis wine: get the processing Zaocys by proportioning, add the airtight immersion of 7～10 times of 40～65 degree Chinese liquor 2 months, stir every day 1 time, get supernatant, filter, promptly get Serpentis wine;
2) preparation of medicated wine: get the clean medical material of Heiguteng exract, Radix Chimonanthi praecocis, Radix Cynanchi Paniculati 3 flavors by proportioning, with 100～120 times of 40～65 degree Chinese liquor reflux, extract, 2 hours, then together with in the medical material impouring container, airtight leaving standstill 2 days got supernatant, and filtration promptly gets medicated wine;
3) preparation: Serpentis wine and medicated wine are merged, and mixing adds the correctives stirring and makes dissolving, adds Chinese liquor and is made into desired concn, and mixing left standstill 24 hours, filters, and fill, promptly.
4, a kind of medicated wine as claimed in claim 1 dispel the wind in preparation, the application in the dehumidifying, analgesic drug product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02150737 CN1228068C (en) | 2002-11-27 | 2002-11-27 | Medicated liquor for dispelling wind, removing alampness and relieving pain, and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02150737 CN1228068C (en) | 2002-11-27 | 2002-11-27 | Medicated liquor for dispelling wind, removing alampness and relieving pain, and preparation process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1502360A CN1502360A (en) | 2004-06-09 |
| CN1228068C true CN1228068C (en) | 2005-11-23 |
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| CN 02150737 Expired - Fee Related CN1228068C (en) | 2002-11-27 | 2002-11-27 | Medicated liquor for dispelling wind, removing alampness and relieving pain, and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100346803C (en) * | 2005-09-19 | 2007-11-07 | 蓝子花 | Tiekuaizi medicated liquor |
| CN103083489B (en) * | 2013-01-24 | 2014-09-17 | 王林祥 | Traditional Chinese medicine wine for treating lumbar spondylosis, cervical spondylosis, early osteoproliferation and old wounds |
| CN112826851A (en) * | 2021-02-08 | 2021-05-25 | 上海和黄药业有限公司 | Analgesic medicine and preparation method and application thereof |
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2002
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