CN100446788C - Externally applied Chinese medicine preparation for treating eczema, tinea of feet and hands, vaginitis, etc and its preparing process - Google Patents
Externally applied Chinese medicine preparation for treating eczema, tinea of feet and hands, vaginitis, etc and its preparing process Download PDFInfo
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Abstract
The present invention relates to an externally used traditional Chinese medicine preparation for treating disease symptoms, such as eczema; eczema, tinea of feet and hands, vaginitis, etc., and a preparation method of the externally used traditional Chinese medicine preparation. The externally used traditional Chinese medicine preparation is composed of flavescent sophora root, phellodendron bark, belvedere fruit, common cnidium fruit, pepper and alum. The prescription of the present invention can aim at the disease causes of the diseases of eczema; eczema, tinea of the feet and hands and vaginitis and correctly apply the principle of pattern identification and treatment; administration. The prescription has the characteristics of simultaneous use of mediicine for treating heat and cold, matching of closure and gathering, mutual supplement, outstanding medication and concise coordination, which is a basic guarantee for good therapeutic effect and is a superior place of the present invention which is compared with the existing congener medicines. In the present invention, the traditional Chinese medicines are refined by the preparation method, the treatment effect of the original medicinal materials is kept, and the preparation which is sanitary has no medicine settlement and is relatively and comfortably used.
Description
Technical field
The present invention relates to a kind of Chinese medicine for outer use for the treatment of pruritus class diseases such as eczema, tinea manus and pedis and vaginitis and preparation method thereof.
Background technology
Pruritus class diseases such as eczema, tinea manus and pedis and vaginitis are several frequently seen and multiple diseases.Also occur some in the market and treated this type of disease Chinese medicine for outer use, as: " JIEERYIN " lotion that En Wei pharmaceutical Co. Ltd in Chengdu produces.They by the skin absorbs medicine, make medicine arrive focus with the method for external fumigation and washing, dipping, infiltration, obtain therapeutic purposes.Chinese medicine is put on the skin and washed is one of outer treating method unique in China's Chinese medicine and pharmacy, and clear " the theoretical parallel prose " sayed: " be cut in skin, thorough in interior reason; as to be photographed air-breathingly, be melted into sepage ", with its medication, can be eliminating evil, look for poison to go out, press down pathogen with internal diabetes, can set upright, Tong Yingwei increases and falls, the reason negative and positive, settling five organs, can setback five strongly fragrant gas, and moneyization source.To wash with the principle of orally taken for curing be consistent so the Chinese medicine external is put on the skin, as long as the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs of correctly using Chinese medicine and pharmacy just can reach good curative effect.Yet, in the market with document in the similar Chinese medicine for outer use reported, also unsatisfactory from curative effect, reason is that etiology and pathogenesis grabs not accurate enoughly, the Therapeutic Principle of formulation is definite inadequately.
Summary of the invention
The objective of the invention is at the problem in the prior art, Chinese medicine for outer use of pruritus class diseases such as the high treatment eczema of a kind of curative effect, vaginitis and preparation method thereof is provided.
The Chinese medicine of China is thought, and is though pruritus class disease pathogenic factors such as eczema, tinea manus and pedis, vaginitis are different, how relevant with " wind, wet, hot, malicious, worm ", " wind being the primary exopathogen, damp and hot being harmonious, locked together; as with the passing of time to pent up poison, infect evil poison and also can cause in worm-eaten the moon." so the present invention is that the Therapeutic Principle carries out prescription with " heat clearing and damp drying, dispelling wind for relieving itching, parasite killing leukorrhagia stopping ", concrete prescription scheme is as follows:
It is prepared from by weight ratio by following component:
Radix Sophorae Flavescentis 255～360 gram Cortex Phellodendris 153～216 gram Fructus Kochiae 127～180 grams
Fructus Cnidii 255～360 gram Pericarpium Zanthoxylies 85～120 Alumens 17～24 grams.
The preferable weight proportion of above-mentioned component is:
Radix Sophorae Flavescentis 290～310 gram Cortex Phellodendris 170～200 gram Fructus Kochiae 140～160 grams
Fructus Cnidii 290～310 gram Pericarpium Zanthoxylies 90～110 Alumens gram 18～21.
By above-mentioned prescription scheme as can be seen, this prescription is made up of Radix Sophorae Flavescentis, Cortex Phellodendri, the Fructus Kochiae, Fructus Cnidii, Pericarpium Zanthoxyli, Alumen, Radix Sophorae Flavescentis wherein, bitter in the mouth is cold in nature, and GUIXIN, lung, kidney, large intestine channel are good at heat clearing and damp drying, dispelling wind for relieving itching, parasite killing leukorrhagia stopping, Qing Dynasty's " book on Chinese herbal medicine converges and says " calls it and is " medicine of the pathogenic fire purging removing dampness and killing parasites that dispels the wind also ", modern medicine studies have shown that also Radix Sophorae Flavescentis has the effect of antiallergic, antiinflammatory, resisting pathogenic microbes, so be monarch drug with it; Cortex Phellodendri, bitter in the mouth is cold in nature, returns kidney, bladder, large intestine channel, the function heat clearing and damp drying, eliminating fire and detoxication, Shennong's Herbal just have the record with Cortex Phellodendri treatment " gynecological's whitish metrorrhagia, pudendal pruritus phagedenoma "; The Fructus Kochiae, the acrid in the mouth bitterness is cold, return kidney, urinary bladder channel, function clearing heat and expelling damp, dispelling wind for relieving itching, the record of useful its " steam in the peeling skin; malignant boil looses " in the Collective Notes to the Canon of Materia medica, " careful south book on Chinese herbal medicine " more spell out the Fructus Kochiae have " wind of the skin of dispelling " and special effect, so be ministerial drug with Cortex Phellodendri, the Fructus Kochiae, help Radix Sophorae Flavescentis heat clearing and damp drying, dispelling wind for relieving itching, parasite killing leukorrhagia stopping; Fructus Cnidii, acrid in the mouth bitterness temperature is returned spleen, kidney channel, the energy warming the kidney to invigorate YANG, removing dampness and killing parasites, dispelling wind for relieving itching, the record of useful its treatment in the Shennong's Herbal " the cloudy fistula pruritus due to damp pathogen of man " has saying of its " main strong wind itching over the body; fry in shallow oil being recovered of soup bath " in " property of medicine opinion ", the bright doctor Chen Shifeng of the Qing Dynasty praises its " function is quite strange, and inside and outside tool can be executed and control, and external treatment is good especially "; Pericarpium Zanthoxyli, acrid in the mouth is warm in nature, returns spleen, stomach, kidney, but killing parasites for relieving itching so the two is adjuvant drug altogether with Fructus Cnidii, Pericarpium Zanthoxyli, had both helped the monarch and his subjects' medicine heat clearing and damp drying, and dispelling wind for relieving itching restricts the property of the monarch and his subjects' medicine bitter cold again, makes it eliminating evil and just do not hinder; Alumen, puckery, acid, cold in nature, the kind dampness of merit is dispeled the wind, and killing parasites for relieving itching is with being messenger drug.Full side forms, and excessive cold invading middle-JIAO(the spleen and stomach) has heat, in loosing receipts is arranged, yin-yang match, coordination of potent and mild therapies, Radix Sophorae Flavescentis bitter cold are monarch, and the Cortex Phellodendri of compatibility bitter cold, the Fructus Kochiae are minister, then heat clearing and damp drying, the antipruritic Li Genghong of pathogenic fire purging, Fructus Cnidii, Pericarpium Zanthoxyli acrid in the mouth are warm in nature, and the two is adjuvant drug altogether, can killing parasites for relieving itching, can restrict the property of the monarch and his subjects' bitter cold again, prevented cold and yang-energy that hurt sb.'s feelings, acrid in the mouth is warm in nature in addition, can inspire people's yang-energy, accelerate evil the dispersing of damp and hot poison, Alumen is for making, and sour and astringent convergence can not only detoxifying and relieving itching, and can restrict the hot diffusing property of adjuvant drug, prevent to disperse too.
In sum, the present invention has caught the cause of disease and the pathogenesis of above-mentioned disease more exactly, in prescription, correctly used the principle of determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, select YAOJING good, assembly is concise, and cold and heat are with using, receiving looses matches, complement each other, this point is the basic assurance that obtains good efficacy, also is its superior part than existing similar drug.
For the curative effect and the medication comfort level that improve this preparation, preparation method of the present invention is as follows:
(1), dissolving Alumen: take by weighing Alumen according to quantity, add the water of 5～7 times of Alumen weight, boil dissolving, filter filtrate for later use;
(2), extract the volatile oil of Fructus Cnidii and Pericarpium Zanthoxyli: take by weighing Fructus Cnidii and Pericarpium Zanthoxyli according to quantity, extract volatile oil with steam distillation, collect volatile oil, water liquid and medicinal residues are standby;
(3), decocting and alcohol extraction Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae: take by weighing Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae according to quantity, and with Fructus Cnidii and Pericarpium Zanthoxyli medicinal residues decocting twice, decocting liquid merges, filter, filtrate is concentrated into relative density 1.10～1.15 (60 ℃), and cooling adds ethanol in the concentrated solution, make ethanol content reach 50～70% of concentrated solution, stir, leave standstill, get supernatant, reclaim ethanol, get extracting solution;
(4), finished product is synthetic: add the Fructus Cnidii of (2) step gained, the volatile oil of Pericarpium Zanthoxyli and the white alum solution of water liquid and (1) step gained in Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae extracting solution of (3) step gained, stir, leave standstill, get supernatant, filter, dilution, get product, the dilution ratio of its herb liquid and water is: 1: 2.8～5.6.
Can more intactly extract the volatile ingredient of volatile components (Fructus Cnidii, Pericarpium Zanthoxyli) by above-mentioned preparation method, this volatile ingredient is extremely important concerning the external preparation, and it can promote the absorption and the osmosis of medicine, improves the whole curative effect of medicine.This preparation method also makes Chinese medicine be made with extra care, and has not only guaranteed to imitate preferably to treat, and also makes it compare health, not have the medicine sediment, uses pleasant.
This preparation has carried out the pharmacodynamics animal experiment by the Shaanxi Province college of traditional Chinese medicine, the Shaanxi Province academy of traditional Chinese medicine, and the result shows: this preparation can significantly resist the mice ear swelling that Oleum Tiglii causes; The effect of itch-threshold of Cavia porcellus is significantly increased; The mice of Dichlorodiphenyl Acetate writhing method has analgesic activity; The mice microcirculation can enlarge markedly the mice external caliber, and the expansion microcirculatory vascular is accelerated blood flow rate, promotes the healing of wound; To escherichia coli, Candida albicans, acrothesium floccosum, microsporum lanosum, staphylococcus aureus, micrococcus catarrhalis, first streptococcus, dysentery bacterium, microsporon gypseum, oidium schoenleinii etc. have inhibitory action; (HSV-Z) has tangible antagonism to the II herpes simplex virus type.
This preparation has carried out the acute toxicity animal experiment by the Shaanxi Province college of traditional Chinese medicine, the Shaanxi Province academy of traditional Chinese medicine, and the result shows: this preparation is 320g/kg to the maximum tolerated dose of mice lavage; This preparation external 8g crude drug/ml does not have the acute toxicity effect to Cavia porcellus complete sum damaged skin; Complete and damaged skin does not all have the obvious stimulation effect to this preparation to Cavia porcellus; This preparation does not have irritated reaction to guinea pig skin; The rat vagina mucosa there is not the obvious stimulation effect.
This preparation is through the attached institute of ShanXi Chinese Medicine Academy, the attached First Academy of Xian Medical Univ, and the clinical observation of the 5th the People's Hospital, Xi'an has obtained comparatively satisfied curative effect.Three tame hospitals observe case 445 examples altogether, wherein 320 examples are organized in treatment, matched group 125 examples, the matched group medication is " JIEERYIN " lotion, respectively acute eczema, tinea manus and pedis, three kinds of diseases of vaginitis have been carried out medication, to acute eczema and tinea manus and pedis patient, medication directly is coated with puts affected part on the skin, to the vaginitis patient, pudendum and washing vagina are cleaned in medication.The result shows: three kinds of cases listing observation in are passed through the treatment of this preparation and " JIEERYIN " lotion respectively, the obvious effective rate of its treatment group and effective percentage are apparently higher than matched group (P＜0.05), prompting is when these three kinds of diseases of treatment, use said preparation curative effect height, short treating period, alleviate patient's misery, be worth promoting clinically.This preparation is under like product is had numerous rivals situation, screens active drug on the empirical basis of doctor family treatment in ancient times, develops in conjunction with for many years clinical experience.Through our clinic trial well-content curative effect is arranged, do not find toxic and side effects.
The specific embodiment
1, prescription:
| The medicine name | Consumption (embodiment 1) | Consumption (embodiment 2) | Consumption (embodiment 3) |
| Radix Sophorae Flavescentis | 255 grams | 290～310 grams | 360 grams |
| Cortex Phellodendri | 153 grams | 170～200 grams | 216 grams |
| The Fructus Kochiae | 127 grams | 140～160 grams | 180 grams |
| Fructus Cnidii | 255 grams | 290～310 grams | 360 grams |
| Pericarpium Zanthoxyli | 85 grams | 90～110 grams | 120 grams |
| Alumen | 17 grams | 18～21 grams | 24 grams |
2, preparation method
(1), dissolving Alumen: take by weighing Alumen according to quantity, add the water of 6 times of Alumen weight, boil dissolving, filter filtrate for later use;
(2), extract the volatile oil of Fructus Cnidii and Pericarpium Zanthoxyli: take by weighing Fructus Cnidii and Pericarpium Zanthoxyli according to quantity, extract volatile oil with steam distillation, collect volatile oil, water liquid and medicinal residues are standby;
(3), decocting and alcohol extraction Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae: take by weighing Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae according to quantity, and with Fructus Cnidii and Pericarpium Zanthoxyli medicinal residues decocting twice, 2 hours for the first time, 1.5 hours for the second time, decocting liquid merged, and filtered, filtrate is concentrated into relative density 1.10～1.15 (60 ℃), is cooled to room temperature, adds ethanol in the concentrated solution, make ethanol content reach 60% of concentrated solution, stir, left standstill 24 hours, get supernatant, reclaim ethanol, get extracting solution;
(4), finished product is synthetic: add the Fructus Cnidii of (2) step gained, the volatile oil of Pericarpium Zanthoxyli and the white alum solution of water liquid and (1) step gained in Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae extracting solution of (3) step gained, stir, leave standstill, get supernatant, filter, dilution, get product, its herb liquid and water dilution ratio are: 1: 2.8～5.6.
Claims (1)
1, a kind of preparation method for the treatment of the Chinese medicine for outer use of eczema, vaginitis, etc, its step is as follows:
(1), dissolving Alumen: take by weighing Alumen 17～24 grams, add the water of 5～7 times of Alumen weight, boil dissolving, filter filtrate for later use;
(2), extract the volatile oil of Fructus Cnidii and Pericarpium Zanthoxyli: take by weighing Fructus Cnidii 255～360 grams and Pericarpium Zanthoxyli 85～120 grams, extract volatile oil with steam distillation, collect volatile oil, water liquid and medicinal residues are standby;
(3), decocting and alcohol extraction Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae: take by weighing Radix Sophorae Flavescentis 255～360 grams, Cortex Phellodendri 153～216 grams and the Fructus Kochiae 127～180 grams, and with Fructus Cnidii and Pericarpium Zanthoxyli medicinal residues decocting twice, decocting liquid merges, filter, filtrate is concentrated into relative density 1.10～1.15 under 60 ℃ temperature, cooling adds ethanol in the concentrated solution, make ethanol content reach 50～70% of concentrated solution, stir, leave standstill, get supernatant, reclaim ethanol, get extracting solution;
(4), finished product is synthetic: add the Fructus Cnidii of (2) step gained, the volatile oil of Pericarpium Zanthoxyli and the white alum solution of water liquid and (1) step gained in Radix Sophorae Flavescentis, Cortex Phellodendri and the Fructus Kochiae extracting solution of (3) step gained, stir, leave standstill, get supernatant, filter, dilution, get product, the dilution ratio of its herb liquid and water is: 1: 2.8～5.6.
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| CN102579602A (en) * | 2012-03-06 | 2012-07-18 | 徐金红 | Medicinal composition for treating eczema |
| CN104027421A (en) * | 2014-06-23 | 2014-09-10 | 广西博士海意信息科技有限公司 | Externally-applied eczema medicament |
| CN104800361B (en) * | 2015-05-07 | 2018-04-10 | 泸州医学院附属中医医院 | A kind of Chinese medicine composition and its production and use |
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| CN113876851B (en) * | 2021-09-27 | 2023-03-21 | 广州中医药大学(广州中医药研究院) | Cedar lotion, preparation method thereof and application thereof in animal fungal dermatopathy |
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| CN1583092A (en) * | 2004-06-14 | 2005-02-23 | 权赫锋 | Chinese medicinal composition for skin diseases |
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| CN1583092A (en) * | 2004-06-14 | 2005-02-23 | 权赫锋 | Chinese medicinal composition for skin diseases |
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| CN1857503A (en) | 2006-11-08 |
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