CN1225641A - 使用具有催化性能的咪唑(如组氨酸)官能团催化剂稳定的过渡配合物进行酰基转移 - Google Patents
使用具有催化性能的咪唑(如组氨酸)官能团催化剂稳定的过渡配合物进行酰基转移 Download PDFInfo
- Publication number
- CN1225641A CN1225641A CN97195516.6A CN97195516A CN1225641A CN 1225641 A CN1225641 A CN 1225641A CN 97195516 A CN97195516 A CN 97195516A CN 1225641 A CN1225641 A CN 1225641A
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- CN
- China
- Prior art keywords
- functional group
- described method
- group
- chemical structure
- imidazoles
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Catalysts (AREA)
Abstract
Description
催化剂 | 速率常数s-1M-1 | 相对速率 |
SA-42RA-42PA-42KO-42LA-424-甲基咪唑富马酸单对硝基苯基酯和TFE | 5.3*10-32.8*10-23.1*10-22.6*10-15.6*10-23.4*10-31.6*10-5 | 331175019371625035002111 |
底物 | 速率常数s-1M-1 | 相对速率 |
KO-424-MeIm富马酸单对硝基苯基酯和TFE | 5.0*10-27.90*10-53.2*10-7 | 1562502471 |
底物 | KO-42s-1M-1 | 4-MeIms-1M-1 | 相对速率 |
富马酸单对硝基苯基酯乙酸对硝基苯基酯环戊烷-1,2-二羧酸单对硝基苯基酯色氨酸对硝基苯基酯(D-和L-) | 0.310.290.863.7 | 7.4*10-47.2*10-41.5*10-35.5*10-3 | 419402573540 |
Claims (37)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9601851A SE9601851D0 (sv) | 1996-05-14 | 1996-05-14 | Catalytic method and structure |
SE96018510 | 1996-05-14 | ||
SE96033238 | 1996-09-12 | ||
SE9603323A SE9603323D0 (sv) | 1996-05-14 | 1996-09-12 | Catalytic method and structure |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1225641A true CN1225641A (zh) | 1999-08-11 |
CN1329410C CN1329410C (zh) | 2007-08-01 |
Family
ID=26662614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN97195516.6A Expired - Fee Related CN1329410C (zh) | 1996-05-14 | 1997-05-13 | 使用具有催化性能的咪唑(如组氨酸)官能团催化剂稳定的过渡配合物进行酰基转移 |
Country Status (10)
Country | Link |
---|---|
US (1) | US6171819B1 (zh) |
EP (1) | EP0952980B1 (zh) |
JP (1) | JP4227193B2 (zh) |
CN (1) | CN1329410C (zh) |
AT (1) | ATE337330T1 (zh) |
AU (1) | AU715521B2 (zh) |
CA (1) | CA2254987A1 (zh) |
DE (1) | DE69736561T2 (zh) |
SE (1) | SE9603323D0 (zh) |
WO (1) | WO1997043302A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114832864A (zh) * | 2022-06-09 | 2022-08-02 | 杭州诺莘科技有限责任公司 | 基于组氨酸和/或烷基取代组氨酸的含金属超分子催化剂及其制备和应用 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998011436A1 (en) * | 1996-09-13 | 1998-03-19 | Whitehead Institute For Biomedical Research | Non-specific affinity enhancement to identify combinatorial library members |
SE9702188D0 (sv) * | 1997-06-06 | 1997-06-06 | Holdingbolaget Vid Goeteborgs | Improved method for site-selective glycosylation |
US6919178B2 (en) | 2000-11-21 | 2005-07-19 | Sunesis Pharmaceuticals, Inc. | Extended tethering approach for rapid identification of ligands |
US6998233B2 (en) | 1998-06-26 | 2006-02-14 | Sunesis Pharmaceuticals, Inc. | Methods for ligand discovery |
US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
SE0001698D0 (sv) | 2000-05-05 | 2000-05-05 | A & Science Invest Ab | Site-selective acyl transfer |
-
1996
- 1996-09-12 SE SE9603323A patent/SE9603323D0/xx unknown
-
1997
- 1997-05-13 US US09/180,670 patent/US6171819B1/en not_active Expired - Lifetime
- 1997-05-13 AU AU29194/97A patent/AU715521B2/en not_active Ceased
- 1997-05-13 CN CN97195516.6A patent/CN1329410C/zh not_active Expired - Fee Related
- 1997-05-13 DE DE69736561T patent/DE69736561T2/de not_active Expired - Lifetime
- 1997-05-13 WO PCT/SE1997/000780 patent/WO1997043302A1/en active IP Right Grant
- 1997-05-13 AT AT97923379T patent/ATE337330T1/de not_active IP Right Cessation
- 1997-05-13 EP EP97923379A patent/EP0952980B1/en not_active Expired - Lifetime
- 1997-05-13 JP JP54079797A patent/JP4227193B2/ja not_active Expired - Fee Related
- 1997-05-13 CA CA002254987A patent/CA2254987A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114832864A (zh) * | 2022-06-09 | 2022-08-02 | 杭州诺莘科技有限责任公司 | 基于组氨酸和/或烷基取代组氨酸的含金属超分子催化剂及其制备和应用 |
Also Published As
Publication number | Publication date |
---|---|
EP0952980B1 (en) | 2006-08-23 |
EP0952980A1 (en) | 1999-11-03 |
DE69736561D1 (de) | 2006-10-05 |
DE69736561T2 (de) | 2007-08-23 |
JP4227193B2 (ja) | 2009-02-18 |
WO1997043302A1 (en) | 1997-11-20 |
CA2254987A1 (en) | 1997-11-20 |
ATE337330T1 (de) | 2006-09-15 |
CN1329410C (zh) | 2007-08-01 |
SE9603323D0 (sv) | 1996-09-12 |
AU715521B2 (en) | 2000-02-03 |
US6171819B1 (en) | 2001-01-09 |
AU2919497A (en) | 1997-12-05 |
JP2000510839A (ja) | 2000-08-22 |
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