CN1225251C - 复方苦丁茶含片及其制备方法 - Google Patents
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Abstract
本发明提供了一种苦丁茶复方含片及其制备方法,含片采用天然植物苦丁茶、金银花、山豆根、玄参、甘草等经粉碎、水提、醇沉、制粒、压片得到,这种苦丁茶复方含片清热解毒、消炎抗菌,对咽喉发炎、口腔溃疡、肠胃热症、高血脂等症有较好治疗效果,既可作为口香糖、润喉糖,也可作为防止口腔、咽喉疾病的清凉含片。
Description
本发明涉及一种具有保健功能的含片,特别是从苦丁茶,金银花等天然植物中提取有效成份的保健含片及其制备方法。
目前国内外的复方含片较多,国内大多数含片也都采用从天然植物中提取有效成份做成,例如草珊瑚含片、西瓜霜含片、金嗓子喉宝、王老吉含片,这些都是精选了中国民间的传统中草药配方经加工得到,有些含片既可作为夏日解暑糖片或口香糖,也可作为清热解毒的药剂,用以治疗咽炎、扁桃体炎、支气管炎,对演员、播音员、教师清润嗓子也起较好作用,对喝酒、吸烟等造成的咽喉痛治愈效果也不错。除了商店、药店公开销售的保健含片或中草药含片外,公开文献也报道过一些用天然植物作为保健饮料或清热解毒药片的内容,如95107874号中国专利公开了含有何首乌、老鹰茶、苦丁茶、金银花、银杏叶、茉莉花提取的浓缩保健液;中国专利99114920也公开了一种由薄荷、桔梗、苦丁茶、甘草、绿茶、啤酒花、金银花等中药为原料制成止渴、消暑、解热的饮料。
从上述公开的专利文献中看到,有的中草药含片或饮料成份较复杂,有的功能单一,有的制备过程工序较多,有效成份提取不完全,有的制成含片后容易返潮,给人们携带或保存带来不方便。
本发明的目的是提供一种从苦丁茶、金银花、山豆根等天然植物中提取有效成份,做成既可作为口香糖、润喉糖、又可作为药用的,具有清热解毒、消炎抗菌的复方苦丁茶含片。
本发明的目的还提供一种制作工序简单,提取有效成份完全,制得含片容易保存和携带,不易吸湿返潮的苦丁茶复方含片的制备方法。
本发明人从中国植物手册及民间了解到许多天然植物具有较好的消炎解毒、清热降火作用,例如苦丁茶、金银花、山豆根、山芝麻、茅根、田基黄等植物,二千多年前我们祖先就用来熬水饮服治疗咽喉发炎,肠胃热症等常见病,许多山区农民还长期用其作为茶或冲剂饮服,它起到清肝利胆、提神醒脑、降火去痧等作用。目前,南方城市居民也常常将这些植物泡茶,增强其保健功能。本发明人经过大量的科学实验和试服用,精选了几种天然植物,从中提取有效成份,将其做成含片剂,发现许多人使用这些含片后对口腔消炎抗菌有作用,对扁桃体、呼吸道发炎等有较好的疗效,还具有提神醒脑、降脂降压、清肝利胆的作用,本发明人经筛选后采用了以下几种植物作为含片原料,其质量百分含量如下(以干物料计):
苦丁茶10-20,金银花15-30,玄参8-20,
山豆根10-20,甘草5-15,薄荷脑0.1-0.5,
本发明复方苦丁茶含片的制备方法主要包括原料粉碎、水回流提取、乙醇沉淀制干膏、加入蔗糖和甜味剂混合制法、干燥、压片、包装等工艺流程,具体制作方法如下:
1.先将上述除薄荷脑以外的原料粗粉碎至颗粒直径≤3毫米(可用湿原料,也可用刚采摘的鲜原料);
2.加8-10倍水回流提取1-2次,每次1-3小时,滤去粗渣;
3.将水提液浓缩至加水量的1/30-1/40,加入70-80%(质量分数)的乙醇进行沉淀,乙醇加入量为浓缩液的5-6倍,沉淀时间为1-2小时,过滤,滤液重复沉淀2-3次,最后浓缩至干膏状,并回收乙醇。
4.按干膏占20%,加入薄荷脑0.1-0.5%、蔗糖50-60%,甜味剂,如阿巴斯甜(Aspartame)、甜茶甙、甜菊甙、罗汉果甙或其它植物提取的甜味素1-2%,淀粉10-15%进行配料。首先将薄荷脑加入到干膏中,加适量70-80%的乙醇润湿后,投入其余组分于制粒机中混合制粒;
5.颗料过16目筛,于60-65℃干燥2-3小时;
6.在干燥好的颗粒中加入按总质量的1%的表面润滑剂,如硬脂酸镁、硬酯酸钙,混合均匀,压片,制成每片1-1.5克的含片,每片约含干膏0.2-0.3克,然后包装得到产品。
以下简述各植物成份的性能与作用:
苦丁茶又名富丁茶、苦登茶,主产于两广,该茶具有多种治疗保健功能,药茶兼用,是我国的珍惜传统保健名茶,在民间流传已有2000多年历史。苦丁茶味甘苦、性寒,具有清热降火、抑菌消炎、提神醒神、降脂降压、去痧利喉等多种药理功效和保健作用。金银花的有效成份为氯原酸和挥发油,具有清热解毒、杀菌消炎、利胆等作用,金银花能与胆固醇结合,从而可减少肠道和胆固醇的吸收。临床上常用于治疗上呼吸道感染、扁桃体炎、咽炎、支气管炎等病症。山豆根为广西特产野生植物,功用主治为清火、解毒、消肿、止痛,可治喉痛、喉风、牙龈肿痛、黄胆、热肿等,许多药物研究所对它的药理进行过研究,发现它有多种功效。玄参,能滋阴、降火、除烦、解毒、咽喉肿痛等症。薄荷、甘草为清凉和辅助作用、能加强疗效和使口感更好。上述几种天然植物一起配合使用,经科学配伍精制,更能发挥各自功能。
本发明的苦丁茶复方含片,采用了水提—乙醇沉淀杂质的方法,提高了有效成分的含量,原料及片剂配方科学考究,从而得到高品质的苦丁茶复方含片。
本发明具有以下优点:
1.由于采用了水提—乙醇沉淀的方法,除掉了大部分杂质,如蛋白质、淀粉、粘液质、脂溶性色素、树脂等,鞣质也能除去大部分。使得干膏中有效成分含量提高。
2.本发明制备的苦丁茶复方含片具有以下保健功能:
①消炎抑菌作用
本品对金黄色葡萄球菌、白色葡萄球菌、伤寒杆菌、甲型、乙型溶血性链球菌等均有抑制作用。
②治疗牙周炎、咽喉炎
临床应用证明,金银花、苦丁茶水提液对牙周炎、牙龈炎、口腔炎、咽喉炎等均有很好治疗作用。
③降脂、降压作用
下面将结合如下实施例对本发明作进一步的说明:
实施例1:
苦丁茶2kg,金银花3kg,玄参2kg,山豆根2kg,甘草1kg共10kg,适当粉碎成小于3毫米的细粒,然后加入10倍量100kg蒸馏水保持微沸回流提取3小时,冷却过滤,滤渣加8倍量蒸馏水800kg重提2小时。合并滤液,浓缩至6L左右,缓慢加入70%乙醇30L,注意边加入边搅拌,静置,过滤。滤液浓缩至糖浆状并回收乙醇,第二次加入75%乙醇30L,重复前次操作。第三次加入80%乙醇30L,重复前次操作,最后浓缩至干膏状,并回收乙醇。按干膏2kg进行片剂的配料。加入0.015kg薄荷脑,用80%乙醇500ml溶解,依次加入6.4kg的蔗糖,1.4kg的淀粉和0.185kg的阿斯巴甜或其它植物甜味素进行混合制粒,颗粒过16目筛,在60℃左右干燥3小时,用14目及80目筛整粒,加入颗粒质量1%的硬脂酸镁混匀,按每片1g进行压片。每片含干膏0.2g。
实施例2:
苦丁茶4kg,金银花6kg,玄参4kg,山豆根4kg,甘草2kg共20kg,适当粉碎成小于3毫米的细粒,然后加入10倍量200kg蒸馏水保持微沸回流提取3小时,冷却过滤,滤渣加9倍量蒸馏水180kg重提1.5小时。合并滤液。滤液浓缩至糖浆状并回收乙醇,第二次加入78%乙醇65L,重复前次操作。最后浓缩至干膏状,并回收乙醇。按干膏4kg进行片剂的配料。加入0.03kg薄荷脑,用80%乙醇1000ml淀解,依次加入13kg的蔗糖,2.57kg的淀粉和0.4kg的阿斯巴甜进行混合制粒,颗粒过16目筛,在60℃左右干燥3小时,用14目及80目筛整粒,加入颗粒质量1%的硬脂酸镁混匀,按每片1g进行压片。每片含干膏0.2g。
Claims (10)
1、一种复方苦丁茶含片,其特征在于它是由下列重量配比的原料制成的:苦丁茶10-20%,金银花15-30%,玄参8-20%,山豆根10-20%,薄荷脑0.1-0.5%,甘草5-15%,其余为辅料,使重量之和达到100%。
2、根据权利要求1所述的复方苦丁茶片,其特征在于所说的辅料为蔗糖、甜味剂、淀粉和表面润滑剂。
3、根据权利要求2所述的复方苦丁茶片,其特征在于所述的甜味剂为阿巴斯甜或甜茶甙、甜菊甙、罗汉果甙,或其它植物提取的甜味素。
4、一种如权利要求1所述的复方苦丁茶含片的制备方法,其特征在于该方法的工艺步骤是先将除薄荷脑以外的原料粉碎,水回流提取,乙醇沉淀制干膏,再加入薄荷脑和蔗糖、甜味剂、淀粉,混合制粒,干燥,加表面润滑剂后压片,包装。
5、根据权利要求4所述的复方苦丁茶含片的制备方法,其特征在于原料的粉碎过程是:将苦丁茶、金银花、玄参、山豆根、甘草粉碎至直径≤3毫米的碎粒。
6、根据权利要求4所述的复方苦丁茶含片的制备方法,其特征在于水回流提取过程是在苦丁茶、金银花、玄参、山豆根、甘草粉碎的原料中加8-10倍水回流提取1-2次,每次1-3小时,滤去粗渣。
7、根据权利要求4所述的复方苦丁茶含片的制备方法,其特征在于乙醇沉淀制干膏的过程是将苦丁茶、金银花、玄参、山豆根、甘草水提取液浓缩至加水量1/30-1/40,加入质量浓度70-80%的乙醇进行沉淀,乙醇加入量为浓缩液的5 6倍,沉淀时间为1-2小时,滤液重复沉淀2-3次,最后浓缩至干膏状,并回收乙醇。
8、根据权利要求4所述的复方苦丁茶含片的制备方法,其特征在于混合制粒的过程是将0.1-0.5%的薄荷脑加到干膏中,然后加入质量浓度70-80%的乙醇润湿后,投入蔗糖50-60%,甜味剂1-2%,淀粉10-15%,在制粒机中制粒。
9、根据权利要求4所述的复方苦丁茶含片的制备方法,其特征在于干燥过程是将在制粒机中制得到的颗粒过16目筛,于60-65℃干燥2-3小时。
10、根据权利要求4所述的复方苦丁茶含片的制备方法,其特征在于压片过程是在干燥好的颗粒中加入按总质量1%的表面润滑剂混合,再压片。
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