CN1215865C - Kidney invigorating Chinese medicine - Google Patents

Abstract

The present invention relates to a Chinese medicine for invigorating the kidney, which is a traditional Chinese medicine especially prepared from the following traditional Chinese medicinal materials of epimedium herb, fenugreek, cherokee rose fruit, prepared rehmannia root, psoralea fruit, common cnidium fruit, fleeceflower root, desertliving cistanche, barbary wolfberry fruit, dodder seed, Chinese magnolivine fruit, palmleaf raspberry pruit, milk vetch, red ginseng, largehead atractylodes rhizome, common yan rhizome, tuckahoe, angelica, chuanxiong rhizome, small fennel, plantain seed and prepared liauorice root.

Description

A kind of kidney-nourishing tcm drug

Technical field

The present invention relates to a kind of kidney-nourishing tcm drug, particularly the Chinese medicine that is mixed with by following Chinese crude drug.

Herba Epimedii, Semen Trigonellae, Fructus Rosae Laevigatae, Radix Rehmanniae Preparata, Fructus Psoraleae, Fructus Cnidii, Radix Polygoni Multiflori, Herba Cistanches, Fructus Lycii Semen Cuscutae, Fructus Schisandrae Chinensis, Fructus Rubi, the Radix Astragali, Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi, Semen Plantaginis, Radix Glycyrrhizae Preparata.

Background technology

The present invention is the agent of the SHENBAO HEJI product of changing products, and SHENBAO HEJI ties up to " danxi's experiential therapy " WUZIYANZONG WAN, " prescription of peaceful benevolent dispensary " decoction of four noble drugs, and the product composition that adds the kidney warming benefit essence on the basis of Jing-Yue Complete Works five happinesses drink.Said preparation records in the 15 105 pages in " the Sanitation Ministry medicine standard " Chinese traditional patent formulation preparation, and said preparation is produced early than approval in 1984.This product was transplanted by Jiangxi Huiren Pharmaceutical Co., Ltd in 1996, and got the Green Light.This side's function cures mainly to YIN and YANG balance regulating, temperature male wind-supplying kidney, the controlling nocturnal emission with astringent drugs of calming the nerves, strengthening the body resistance, be used for that sexual impotence, seminal emission, waist and leg ache, lassitude, nocturia, fear of cold are afraid of cold, women's menorrhagia, all diseases of clear and thin leucorrhea.Nineteen ninety-five is treated deficiency of kidney-YANG syndrome 302 examples altogether through clinical trial, and clinical total effective rate is 79.8%.In clinical practice for many years,, be subjected to the welcome of middle-older patient deeply subsequently because determined curative effect is safe and reliable.

Because SHENBAO HEJI uses traditional method for making, complex process is taken inconvenience, thus need on the market that a kind of curative effect is better, safe ready, little, the cheap pure traditional Chinese compound medicine of side effect.

Summary of the invention

The present invention follows " inherit and do not obstinately follow tradition; development is not from the ancestor " basic principle that this Chinese medicine is inherited and development should be followed, keeping former prescription and function to cure mainly under the situation about not changing, be convenient to the film coated tablet taking, store, carry and transport by adopting new techniques such as modern high efficiency extraction, separation, purification that this dosage form is reformed, being prepared into.

We's flavour of a drug are more, the complicated component of medical material, saponin, trigonelline, pentahydroxy-methyl furfural, psoralen, osthole, ergosterol, betanin, schisandrol, ferulic acid, anisaldehyde, linolenate glycyrrhizic acid ammonia etc. are arranged, the part medical material also contains volatile oil, for reduce loss of active ingredients as far as possible, should be earlier to part medicinal material extract volatile oil: contain the medical material of saponin component, use alcohol reflux; The method that all the other medical materials adopt decocting to extract, and adopt the secondary precipitate with ethanol to separate impurity removing technology with high speed centrifugation, the impurity of removing as much as possible, reduce the rate of extract, reduce dose, make that the tablet of making can reach the curative effect height, dosage is little, toxic and side effects is little, be convenient to the purpose of transporting, store, carrying and taking again, can also overcome the stable inadequately shortcoming of liquid preparation, the storage life is prolonged, so select tablet more suitable.

Chinese medicine preparation of the present invention has YIN and YANG balance regulating, temperature male wind-supplying kidney, the controlling nocturnal emission with astringent drugs of calming the nerves, the effect of strengthening the body resistance, cure mainly insufficiency of kidney-YANG, essence and blood loses empty, and disease sees that sexual impotence, seminal emission, waist and leg ache, lassitude, nocturia, fear of cold are afraid of cold, women's menorrhagia, clear and thin leucorrhea, diseases such as pale tongue with thin fur, deep-thready pulse.

Chinese medicine preparation of the present invention, its prescription adopts SHENBAO HEJI prescription, theory of Chinese medical science thinks that kidney is a congenital foundation, viscus attributed to water and fire, vigour is gathered, for Yuanyang at all.Insufficiency of kidney-YANG, essence and blood lose empty many because of due to eipathia asthenia or the impairment of the kidney due to indulgence in sexual activities.Unit's YANG deficiency is lost in warm, so aversion to cold and cold limbs; Waist is a house of kidney, and so kidney governing bones is suffered from a deficiency of the kidney waist and leg ache; Kidney unit loses empty, essence and blood void, can not support gods, then lassitude or mind uneasiness and having a sleepless night; Kidney storing essence, main reproduction, the yang deficiency fire declines, and dysfunction of the kidney in storing essence smart closes admittedly, or suffer from a deficiency of the kidney can not astringency inducing, so sexual impotence, seminal emission, nocturia, women's clear and thin leucorrhea or menorrhagia; Pale tongue with thin fur, deep-thready pulse are insufficiency of kidney-YANG, and essence and blood loses empty resembling.Control suitable temperature male wind-supplying kidney, the nourishing kidney controlling nocturnal emission with astringent drugs is main.We tie up to the product composition that adds the kidney warming benefit essence on the basis of " danxi's experiential therapy " WUZIYANZONG WAN, " prescription of peaceful benevolent dispensary " decoction of four noble drugs and Jing-Yue Complete Works five happinesses drink.Side's Herba Epimedii, Semen Trigonellae warming the kidney to invigorate YANG, beneficial smart Conclusion Decreasing, bone and muscle strengthening; The Radix Rehmanniae Preparata replenishing kidney-essence; The sour and astringent convergence of Fructus Rosae Laevigatae, tool controlling nocturnal emission with astringent drugs, reducing urination, leukorrhagia stopping effect, four flavors are we's monarch drug, the warming the kidney to invigorate YANG that tool is very strong, replenishing essence controlling nocturnal emission with astringent drugs effect altogether.Fructus Psoraleae, Fructus Cnidii, Herba Cistanches warming YANG to expel cold, the warm unit down of principal drug assistance; Fructus Lycii, Semen Cuscutae, Radix Polygoni Multiflori Preparata benefiting essence and marrow, enriching yin and nourishing kidney, the justice of getting " treating YANG within YIN ", then can " YIN and YANG in a relative equilibrium ", YIN and YANG balance regulating; Fructus Schisandrae Chinensis, Fructus Rubi reinforce the kidney end to lose, relieving leukorrhea by astringents, more than eight flavor medicines all can strengthen the effect of monarch drug, be we's ministerial drug altogether.The Radix Astragali, Radix Ginseng Rubra, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Poria invigorating the spleen and replenishing QI are mended the foundation of acquired constitution, make guiding drug functional activities of the body fluid four so far, and then the machine convection on the whole body is logical, the essence of water and grain compress; Radix Angelicae Sinensis, Rhizoma Chuanxiong benefiting blood and regulating blood circulation; But the Fructus Foeniculi the kidney warming warms up liver, dispersing cold for relieving pain, Poria, Fructus Schisandrae Chinensis mind tranquilizing and the heart calming again; Wonderful at Herba Plantaginis simply, rush down and logical it, it is turbid to rush down tangible heresy, it is logical to hold concurrently in puckery, tonify without causing stagnation, last nine to distinguish the flavor of be adjuvant drug altogether.Make with the Radix Glycyrrhizae Preparata YIN and YANG balance regulating mediation spleen kidney, mediation reinforcing and reducing, coordinating the actions of various ingredients in a prescription.

Above-mentioned 22 the flavor medicines join and, supporing yang YIN nourishing, YIN and YANG balancing, the property of medicine is gentle, the temperature and not dry, tonify without causing stagnation really is the treasured of kidney tonifying.Essence in kidney is abundant, just is being so incensed that to fill, and can improve the resistance against diseases of body, and the invasion and attack of defence exopathogen are so we also have the effect of strengthening the body resistance.In sum, we's function is a YIN and YANG balance regulating, temperature male wind-supplying kidney, the controlling nocturnal emission with astringent drugs of calming the nerves, strengthening the body resistance.Be used for deficiency of kidney essence, all diseases of imbalance of YIN and YANG, determined curative effect.

The invention reside on the traditional handicraft basis technology is improved, wherein improvements mainly contain:

1. Herba Epimedii is extracted by percolation and change reflux, extract, into, improved content Determination of Icariin

This prescription is made up of 22 flavor medical materials, and wherein Herba Epimedii is one of monarch drug.Main Ingredients and Appearance is an icariin etc., and former process using is mixed with the four Chinese medicine materials such as Fructus Cnidii that other contains volatile oil, makes solvent with 70% ethanol, floods percolation extraction after 48 hours, and decompression recycling ethanol is stand-by after concentrating again; The Radix Ginseng Rubra Main Ingredients and Appearance is ginsenoside etc.Former process using 20% alcohol dipping reflux, extract, after 8 hours, medicinal residues are sneaked into row decoction extraction again in other medical materials.Owing to mainly contain the glycoside active ingredient in the above-mentioned 2 flavor medical materials.Shortcomings such as former technology extracting method is time-consuming, and the solvent use amount is bigger, and extracts active ingredients is incomplete.Therefore, Herba Epimedii is contained the medical material separate processes of volatile oil, the experiment proved that Herba Epimedii, Radix Ginseng Rubra two flavor medical materials are mixed, adopt 50% alcohol reflux, reclaim add to behind the ethanol carry out in the water extract-alcohol precipitation liquid remove impurity handle comparatively reasonable.Icariin content is than the percolation height in the reflux extracting liquid, and refluxes and carry substantially for twice to the greatest extent.

By infiltration filter method (SHENBAO HEJI technology) icariin content be: 10.67mg/ml

By circumfluence method (renal aid blade technolgy) icariin content be: 12.59mg/ml.

2. Radix Ginseng Rubra is changed into 50% ethanol with the Herba Epimedii reflux, extract, by 20% alcohol reflux, improved the content of Radix Ginseng Rubra Rgl and Re, be respectively 1.627mg/ml; 8.605mg/ml.

3. the medical material that Fructus Cnidii etc. is contained volatile oil is extracted by percolation and changes vapor distillation into and extract volatile oil, and volatile oil and through micropowder silica gel absorption directly adds tabletting in the granule, and the composition that has kept volatile oil has improved the utilization rate of volatile oil.

Contain the volatility active ingredient in the side in Fructus Cnidii, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Fructus Foeniculi, former process using and Herba Epimedii merge percolation and extract, and reclaim ethanol again, and volatile ingredient is because of reclaiming ethanol, and are distilled with ethanol, and technology is unreasonable.Therefore above-mentioned 4 flavor medical materials are merged with the Fructus Schisandrae Chinensis that also contains volatile oil, the Rhizoma Atractylodis Macrocephalae, extract volatile oil through vapor distillation, volatile oil directly adds tabletting in the granule again with after a small amount of differential silica gel mixing and absorption, has kept the composition of volatile oil.Mother solution after distillation device collection is in addition handled with the decocting liquid merging of decocting herbs.Through evidence, vapor distillation 10 hours, volatile oil are carried to the greatest extent substantially.Medical material has been owing to decocted 10 hours, thus medicinal residues decocting no longer, directly with mother solution in addition the decocting liquid preserved with decocting herbs of device merge processing.

4. the decocting part is changed into ethanol precipitation twice and removed impurity through high speed centrifugation by a precipitate with ethanol, reduced the rate of extract and dwindled volume, reduced dose.

Former technology is with 16 flavor medical materials such as Fructus Rubies, adding water (10 times of amounts of medical material) decocts 2 times, each 2 hours, merge decoction liquor, filter, filtrate is concentrated into relative density 1.16 (80 ℃), add 95% ethanol and make into 85% concentration, precipitate 48 hours, get supernatant and reclaim ethanol, be concentrated into relative density 1.16 (80 ℃), standby.This technology is carried out vapor distillation with the medical material that 4 flavors such as Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae and Fructus Cnidii in this 16 flavor medical material contain volatile oil.All the other 14 flavor medical materials mainly contain water-soluble components, so adopt decocting to boil, decocting liquid merges with the decocting liquid of carrying behind the oil, has adopted ethanol precipitation twice (65%, 85%), impurity-removing method, be selection indicators and be that reference index is tested with psoralen and isopsoralen total amount with the rate of extract.The result shows: handle to such an extent that the cream amount is the 13.71g/92.4g medical material by alcohol deposition method of SHENBAO HEJI technology, psoralen and isopsoralen total amount are the 11.34mg/92.4g medical material; Handle to such an extent that the cream amount is the 10.45g/92.4g medical material by renal aid blade technolgy secondary precipitate with ethanol, psoralen and isopsoralen total amount are the 11.0mg/92.4g medical material.

5. adopt the spray drying method for preparation extract powder, row is granulated again.Can shorten man-hour greatly than vacuum drying and constant pressure and dry.Because of this technology extracting solution viscosity bigger, be prone to spray nozzle clogging, the seriously sticking wall of the extract powder of ejection, through test, treating that hydrojet (relative density is 1.05,50 ℃) adds 5% left and right sides soluble dextrins, after the stirring and dissolving, spray drying (inlet temperature is 176 ℃), 86.5 ℃ of leaving air temps, average pressure reduction 197.5kpa).Obtain satisfactory result.Three batches of spraying extract powder the rate of extract are respectively 9.5% (020529), 8.8% (020530), 8.9% (020531).

6. add the method for disintegrating agent in adopting, shortened the disintegration time of renal aid sheet.Not with disintegrating agent, disintegration is on average greater than 60 minutes; Only add disintegrating agent when the system granule, adopt inside and outside addition on average at 40 minutes disintegration, adds the fine little element of 5% hydroxypropyl when promptly making granule, mixes the fine little element of 5% hydroxypropyl with granule, and disintegration is on average at 35 minutes.

7. the thin film coating material that adopts Film coated tablets is to adopt the multi-functional Opadry II of high efficiency, low cost type thin film coating material.This material is to be solvent with full water, can save the coating time, enhances productivity, and the coating time only needs 1.0-1.5 hour, and coating solution can be prepared in 30-45 minute and finishes.Label there is high adhesive force, gloss and slickness are preferably arranged, also can increase the stability of color.These characteristics had both kept good tablet appearance also to increase flowability, were convenient to the packing of tablet.

8. owing to be prepared into the renal aid Film coated tablets, compare with SHENBAO HEJI and not only got rid of 20% sucrose but also got rid of antiseptic (1 ‰ sodium benzoate, 0.5 ‰ ethyl hydroxybenzoate).

The agent of this project is changed products product in technology content, and product appearance is taken and the aspect such as carried bigger improvement and raising are all arranged, and product will have good market prospect.

Chinese medicine preparation of the present invention, its prescription consists of:

Herba Epimedii 157-630 part Semen Trigonellae 156-626 Fructus Rosae Laevigatae 157-630 part Radix Rehmanniae Preparata 156-626 part

Fructus Psoraleae 47-190 part Fructus Cnidii 46-186 part Radix Polygoni Multiflori 124-496 part Herba Cistanches 78-314 part

Fructus Lycii 110-440 part Semen Cuscutae 110-440 part Fructus Schisandrae Chinensis 60-240 part Fructus Rubi 55-220 part Huang

Stilbene 85-342 part Radix Ginseng Rubra 33-132 part Rhizoma Atractylodis Macrocephalae 23-94 part Rhizoma Dioscoreae 77-308 part

Poria 50-200 part Radix Angelicae Sinensis 78-312 part Rhizoma Chuanxiong 47-188 part Fructus Foeniculi 24-96 part

Semen Plantaginis 27-110 part Radix Glycyrrhizae Preparata 23-94 part

Preferably

Herba Epimedii 236-420 part Semen Trigonellae 234-417 part Fructus Rosae Laevigatae 236-420 part Radix Rehmanniae Preparata 234-417 part

Fructus Psoraleae 71-126 part Fructus Cnidii 69-124 part Radix Polygoni Multiflori 186-330 part Herba Cistanches 117-209 part

Fructus Lycii 165-293 part Semen Cuscutae 165-293 part Fructus Schisandrae Chinensis 90-160 part Fructus Rubi 81-145 part

Radix Astragali 128-228 part Radix Ginseng Rubra 49-88 part Rhizoma Atractylodis Macrocephalae 35-62 part Rhizoma Dioscoreae 115-205 part

Poria 75-133 part Radix Angelicae Sinensis 117-208 part Rhizoma Chuanxiong 70-125 part Fructus Foeniculi 36-64 part

Semen Plantaginis 41-73 part Radix Glycyrrhizae Preparata 35-62 part

Be more preferably

313 parts of 315 parts of Radix Rehmanniae Preparata of 313 portions of Fructus Rosae Laevigatae of 315 parts of Semen Trigonellae of Herba Epimedii

157 parts of 248 parts of Herba Cistanches of 93 parts of Radix Polygoni Multiflori Preparatas of 95 parts of Fructus Cnidiis of Fructus Psoraleae

109 parts of 120 portions of Fructus Rubies of 220 parts of Fructus Schisandrae Chinensis of 220 parts of Semen Cuscutae of Fructus Lycii

154 parts of 47 portions of Rhizoma Dioscoreaes of 66 parts of Rhizoma Atractylodis Macrocephalaes of 171 parts of Radix Ginseng Rubra of the Radix Astragali

48 parts of 94 parts of Fructus Foeniculi of 156 parts of Rhizoma Chuanxiongs of 100 parts of Radix Angelicae Sinensis of Poria

47 parts of 55 parts of Radix Glycyrrhizae Preparatas of Semen Plantaginis

Its method for making of Chinese medicine preparation of the present invention is as follows:

More than 22 flavors, get Herba Epimedii, Radix Ginseng Rubra coarse powder with 10 times of amount 50% soak with ethanol 1 hour, reflux, extract, 2 times, each 2 hours, merge extractive liquid,, recovery ethanol is condensed into relative density and is the medicinal liquid of 1.05 (50 ℃), and is stand-by; Get Fructus Cnidii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi coarse powder, add 12 times of water gagings and soaked 40 minutes, extract volatile oil, the decocting liquid liquid after distillation device is in addition collected; Get all the other ten four Chinese medicine materials such as Fructus Rosae Laevigatae, add the water of 12 times of amounts, soaked 40 minutes, decocting secondary, each 1 hour.Decocting liquid merges with the decocting liquid of carrying behind the oil.Amalgamation liquid is condensed into the medicinal liquid that relative density is 1.10 (50 ℃), add ethanol and reach 65% to containing the alcohol amount, leave standstill more than 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is that 1.12 (50 ℃) add Herba Epimedii, the Radix Ginseng Rubra alcohol extract stirs evenly, and adds ethanol and reaches 85% to containing the alcohol amount, precipitation is more than 12 hours, reclaim ethanol, being concentrated into relative density is that 1.05 (50 ℃) are centrifugal, adds 5% soluble dextrins in the filtrate, spray drying, make dry extract, sneak into volatile oil and obtain effective ingredient, can be made into any medicament according to a conventional method with this effective ingredient.

As make the dry extract that spray drying obtains in the desirable above-mentioned preparation of tablet, add an amount of, 5% hydroxypropyl cellulose of micropowder silica gel, mix, sieve, the system granule, dry, put coldly, sneak into volatile oil, 5% hydroxypropyl cellulose, 1.0% magnesium stearate, suppress 1000 in blocks with micropowder silica gel absorption, the bag film-coat, promptly.During prescription of the present invention was formed, weight was calculated with crude drug, if be unit with the gram, this composition can be made into 1000 doses of pharmaceutical preparatioies, the final drug preparation that described 1000 doses of fingers are made, as make 1000 of capsule preparations, 1000 in tablet, 1000 bags of granules, oral liquid 1000 ampoules etc. also can be made big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.

More than form, as if being unit with the gram, can be made into the preparation of 50-1000 taking dose, as tablet, make 1000, each taking dose can be the 1-20 sheet, can take 50-1000 time altogether.As granule, make 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether.

More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with gram or milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.

The ratio of above weight proportion obtains through science screening, for especial patient, and the proportioning of can corresponding adjustment forming, the amount that each component increases or reduces is no more than 100% of most preferred amount.

Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.

Chinese medicine preparation of the present invention, can add the medicine acceptable carrier when being prepared into medicament, described medicine acceptable carrier can be: starch, sucrose, lactose, mannitol, silicon derivative, cellulose and derivant thereof, alginate, gelatin, polyvinylpyrrolidone, glycerol, soil temperature 80, agar, calcium carbonate, calcium bicarbonate, surfactant, Polyethylene Glycol, cyclodextrin, beta-schardinger dextrin-, phospholipid material, Kaolin, Pulvis Talci, calcium stearate, magnesium stearate etc.

Chinese medicine preparation of the present invention can be any pharmaceutically useful dosage form, and these dosage forms comprise: tablet, sugar coated tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, suck agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, powder, solution, injection, suppository, ointment, plaster, cream, spray, drop, patch.Preparation of the present invention, peroral dosage form preferably, as: capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, unguentum etc., preferably tablet.

Preparation of the present invention is determined usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20 agent, as: 1-20 bag or grain or sheet.

Below by effect experiment beneficial effect of the present invention is described.

Use the tablet of the method preparation of embodiment 1 to be called the SB tablet in the experiment, positive control uses SHENBAO HEJI, is called the SB mixture.Experimental result sees Table 1-7.

The specific embodiment:

Further specify the present invention by the following examples.

Embodiment 1

The preparation of tablet

Herba Epimedii 315.3g Semen Trigonellae 313.3% Fructus Rosae Laevigatae 315.3g Radix Rehmanniae Preparata 313.3g

Fructus Psoraleae 95.0g Fructus Cnidii 93.3g Radix Polygoni Multiflori Preparata 248.0g Herba Cistanches 157.7g

Fructus Lycii 220.0g Semen Cuscutae 220.0g Fructus Schisandrae Chinensis 120.0g Fructus Rubi 109.7g

Radix Astragali 171.3g Radix Ginseng Rubra 66.7g Rhizoma Atractylodis Macrocephalae 47.3g Rhizoma Dioscoreae 154.3g

Poria 100.0g Radix Angelicae Sinensis 156.0g Rhizoma Chuanxiong 94.3g Fructus Foeniculi 48.0g

Semen Plantaginis 55.0g Radix Glycyrrhizae Preparata 47.3g

More than 22 flavors, get Herba Epimedii, Radix Ginseng Rubra coarse powder with 10 times of amount 50% soak with ethanol 1 hour, reflux, extract, 2 times, each 2 hours, merge extractive liquid,, recovery ethanol is condensed into relative density and is the medicinal liquid of 1.05 (50 ℃), and is stand-by; Get Fructus Cnidii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi coarse powder, add 12 times of water gagings and soaked 40 minutes, extract volatile oil, the decocting liquid liquid after distillation device is in addition collected; Get all the other ten four Chinese medicine materials such as Fructus Rosae Laevigatae, add the water of 12 times of amounts, soaked 40 minutes, decocting secondary, each 1 hour.Decocting liquid merges with the decocting liquid of carrying behind the oil.Amalgamation liquid is condensed into the medicinal liquid that relative density is 1.10 (50 ℃), add ethanol and reach 65%, leave standstill more than 12 hours, filter to containing the alcohol amount, filtrate recycling ethanol, being concentrated into relative density is that 1.12 (50 ℃) add Herba Epimedii, the Radix Ginseng Rubra alcohol extract stirs evenly, and adds ethanol and reaches 85% to containing the alcohol amount, precipitation is more than 12 hours, reclaim ethanol, being concentrated into relative density is that 1.05 (50 ℃) are centrifugal, adds 5% soluble dextrins in the filtrate, spray drying, make dry extract, it is an amount of to add micropowder silica gel, 5% hydroxypropyl cellulose mixes, sieve, the system granule, drying is put cold, sneak into volatile oil with micropowder silica gel absorption, 5% hydroxypropyl cellulose, 1.0% magnesium stearate, suppress 1000 in blocks, the bag film-coat, promptly.

Embodiment 2

The preparation of capsule

Herba Epimedii 315.3g Semen Trigonellae 313.3% Fructus Rosae Laevigatae 315.3g Radix Rehmanniae Preparata 313.3g

Fructus Psoraleae 95.0g Fructus Cnidii 93.3g Radix Polygoni Multiflori Preparata 248.0g Herba Cistanches 157.7g

Fructus Lycii 220.0g Semen Cuscutae 220.0g Fructus Schisandrae Chinensis 120.0g Fructus Rubi 109.7g

Radix Astragali 171.3g Radix Ginseng Rubra 66.7g Rhizoma Atractylodis Macrocephalae 47.3g Rhizoma Dioscoreae 154.3g

Poria 100.0g Radix Angelicae Sinensis 156.0g Rhizoma Chuanxiong 94.3g Fructus Foeniculi 48.0g

Semen Plantaginis 55.0g Radix Glycyrrhizae Preparata 47.3g

More than 22 flavors, get Herba Epimedii, Radix Ginseng Rubra coarse powder with 10 times of amount 50% soak with ethanol 1 hour, reflux, extract, 2 times, each 2 hours, merge extractive liquid,, recovery ethanol is condensed into relative density and is the medicinal liquid of 1.05 (50 ℃), and is stand-by; Get Fructus Cnidii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi coarse powder, add 12 times of water gagings and soaked 40 minutes, extract volatile oil, the decocting liquid liquid after distillation device is in addition collected; Get all the other ten four Chinese medicine materials such as Fructus Rosae Laevigatae, add the water of 12 times of amounts, soaked 40 minutes, decocting secondary, each 1 hour.Decocting liquid merges with the decocting liquid of carrying behind the oil.Amalgamation liquid is condensed into the medicinal liquid that relative density is 1.10 (50 ℃), adds ethanol and reaches 65% to containing the alcohol amount, leaves standstill more than 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is that 1.12 (50 ℃) add Herba Epimedii, the Radix Ginseng Rubra alcohol extract, stir evenly, add ethanol and reach 85% to containing the alcohol amount, precipitation reclaimed ethanol more than 12 hours, being concentrated into relative density is that 1.05 (50 ℃) are centrifugal, the soluble dextrins of adding 5% in the filtrate, spray drying is made dry extract, it is an amount of to add micropowder silica gel, 5% hydroxypropyl cellulose, mix, sieve, the system granule, dry, put coldly, sneak into volatile oil with micropowder silica gel absorption, mixing, 1000 gelatine capsules of packing into.

Embodiment 3

The preparation of granule

Herba Epimedii 315.3g Semen Trigonellae 313.3% Fructus Rosae Laevigatae 315.3g Radix Rehmanniae Preparata 313.3g

Fructus Psoraleae 95.0g Fructus Cnidii 93.3g Radix Polygoni Multiflori Preparata 248.0g Herba Cistanches 157.7g

Fructus Lycii 220.0g Semen Cuscutae 220.0g Fructus Schisandrae Chinensis 120.0g Fructus Rubi 109.7g

Radix Astragali 171.3g Radix Ginseng Rubra 66.7g Rhizoma Atractylodis Macrocephalae 47.3g Rhizoma Dioscoreae 154.3g

Poria 100.0g Radix Angelicae Sinensis 156.0g Rhizoma Chuanxiong 94.3g Fructus Foeniculi 48.0g

Semen Plantaginis 55.0g Radix Glycyrrhizae Preparata 47.3g

More than 22 flavors, get Herba Epimedii, Radix Ginseng Rubra coarse powder with 10 times of amount 50% soak with ethanol 1 hour, reflux, extract, 2 times, each 2 hours, merge extractive liquid,, recovery ethanol is condensed into relative density and is the medicinal liquid of 1.05 (50 ℃), and is stand-by; Get Fructus Cnidii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi coarse powder, add 12 times of water gagings and soaked 40 minutes, extract volatile oil, the decocting liquid liquid after distillation device is in addition collected; Get all the other ten four Chinese medicine materials such as Fructus Rosae Laevigatae, add the water of 12 times of amounts, soaked 40 minutes, decocting secondary, each 1 hour.Decocting liquid merges with the decocting liquid of carrying behind the oil.Amalgamation liquid is condensed into the medicinal liquid that relative density is 1.10 (50 ℃), adds ethanol and reaches 65% to containing the alcohol amount, leaves standstill more than 12 hours, filter, filtrate recycling ethanol, being concentrated into relative density is that 1.12 (50 ℃) add Herba Epimedii, the Radix Ginseng Rubra alcohol extract, stir evenly, add ethanol and reach 85% to containing the alcohol amount, precipitation is more than 12 hours, reclaim ethanol, being concentrated into relative density is that 1.05 (50 ℃) are centrifugal, adds 5% soluble dextrins in the filtrate, spray drying, make dry extract, it is an amount of to add micropowder silica gel, 5% hydroxypropyl cellulose, sucrose 80g, mix, sieve system granule, drying, put cold, sneak into the volatile oil with micropowder silica gel absorption, mixing is dressed up 250 bags granule.

Table 1 renal aid tablet and mixture are to the influence of insufficiency of kidney-YANG mice body weight and body temperature (X ± S)

After the preceding modeling of group modeling

Body weight (g) body temperature (℃) body weight (g) body temperature (℃)

Normal control group 25.8 ± 2.13 37.3 ± 0.57 29.05 ± 2.30 37.3 ± 0.46

Insufficiency of kidney-YANG model group 26.5 ± 2.23 37.7 ± 0.35 26.2 ± 2.40 36.9 ± 0.46**

Give birth to arteries and veins liquid group 28.3 ± 2.20 37.4 ± 0.43 29.0 ± 2.63 37.1 ± 0.49

SB sheet low dose group 29.9 ± 1.45 37.3 ± 0.46 29.7 ± 1.64 37.4 ± 0.42

Dosage group 29.8 in the SB sheet ± 1.36 37.3 ± 0.38 30.1 ± 1.21 37.2 ± 0.46

SB sheet high dose group 30.0 ± 1.30 37.3 ± 0.29 30.3 ± 2.36 37.3 ± 0.27

SB closes low dose group 28.4 ± 1.79 36.8 ± 0.57 27.7 ± 2.94 36.9 ± 0.48

SB closes middle dosage group 27.7 ± 2.27 36.9 ± 0.47 27.1 ± 3.32 36.9 ± 0.49

SB closes high dose group 28.5 ± 2.30 37.0 ± 0.42 27.9 ± 2.75 37.2 ± 0.31

Compare * P＜0.05 * * P＜0.01 before and after the model group modeling;

Compare P＞0.05 before and after renal aid tablet and the mixture modeling

Table 2 renal aid tablet and mixture are to the influence of autonomic activities number of times and the swimming time of insufficiency of kidney-YANG mice (X ± S)

Group dosage number of animals autonomic activities number of times swimming time

(g.kg) (only) (in the 10min) (second)

Normal control group equivalent NS 19 30.68 ± 14.29 650.89 ± 420.82

Insufficiency of kidney-YANG model group NS+ hydrogen can 19 16.86 ± 6.25##, 198.67 ± 103.60##

Giving birth to arteries and veins liquid group 10ml+ hydrogen can 19 23.35 ± 7.41**, 306.88 ± 174.05*

SB sheet low dose group 7.5+ hydrogen can 19 24.24 ± 6.83**, 302.47 ± 154.37*

Dosage group 15+ hydrogen can 19 24.88 ± 10.75*, 303.41 ± 171.21* in the SB sheet

SB sheet high dose group 30+ hydrogen can 19 23.06 ± 8.36*, 324.67 ± 201.08*

SB closes low dose group 7.5+ hydrogen can 19 22.61 ± 6.61* 255.94 ± 123.82

Dosage group 15+ hydrogen can 19 22.56 ± 6.98*, 336.11 ± 239.67* during SB closed

SB closes high dose group 30+ hydrogen can 19 19.94 ± 6.82 279.94 ± 122.65*

Relatively compare with the normal control group * P＜0.05 * * P＜0.01 with the insufficiency of kidney-YANG model group

#P＜0.05 ##P＜0.01; Renal aid tablet and mixture be P＞0.05 relatively

Experimental result shows: the insufficiency of kidney-YANG mouse temperature obviously descends, the autonomic activities number of times reduces, the spirit atrophy, swimming time shortens, relatively has significant difference (P＜0.01) with the normal control group, prompting, modeling is successful, renal aid tablet 7.5g/kg, 15g/kg and 30g/kg dosage group can prevent the decline of insufficiency of kidney-YANG mouse temperature, increase the autonomic activities number of times and prolong swimming time, SHENBAO HEJI 7.5g/kg, 15g/kg dosage group can increase the autonomic activities number of times, 15g/kg and 30g/kg dosage group can prolong swimming time, renal aid tablet and SHENBAO HEJI are not seen notable difference (P＞0.05) prompting: renal aid tablet and SHENBAO HEJI all have the antifatigue effect, and be comparatively remarkable with the effect of renal aid tablet

Table 3 renal aid tablet and SHENBAO HEJI are to the influence of insufficiency of kidney-YANG animal viscera coefficient (X ± S)

Group body weight spleen index thymus index adrenal gland index

Normal control group 30.3 ± 3.89 0.065 ± 0.017 0.0278 ± 0.0071 0.0039 ± 0.0014

Model control group 25.1 ± 4.08# 0.047 ± 0.021## 0.0099 ± 0.0038## 0.0034 ± 0.0013

Give birth to arteries and veins liquid group 25.8 ± 2.75 0.046 ± 0.017 0.0131 ± 0.0033**, 0.0046 ± 0.0017*

The low group 26.5 ± 3.55 0.040 ± 0.010 0.0131 ± 0.0074 0.0045 ± 0.0017 of SB tablet

Organize 25.9 ± 3.33 0.047 ± 0.021 0.0138 ± 0.0066* 0.0039 ± 0.0014 in the SB tablet

The high group of SB tablet 25.6 ± 3.29 0.039 ± 0.015 0.0148 ± 0.0045**, 0.0045 ± 0.0017*

The low group 23.4 ± 4.84 0.041 ± 0.012 0.0119 ± 0.0019 0.0040 ± 0.0012 of SB mixture

Organize 25.4 ± 3.37 0.042 ± 0.012 0.0123 ± 0.0025* 0.0040 ± 0.0020 in the SB mixture

The high group of SB mixture 24.9 ± 3.67 0.041 ± 0.021 0.0123 ± 0.0026* 0.0041 ± 0.0014

Compare * P＜0.05 * * P＜0.01 with the insufficiency of kidney-YANG model group; Compare with the normal control group

#P＜0.05 ##P＜0.01; Renal aid tablet and mixture be P＞0.05 relatively

Table 4 renal aid tablet and SHENBAO HEJI are to the influence of insufficiency of kidney-YANG animal viscera coefficient (X ± S)

Group testis index seminal vesicle index preputial glands index

Normal control group 0.0498 ± 0.0103 0.0291 ± 0.0105 0.0168 ± 0.0048

Model control group 0.0610 ± 0.0158## 0.0229 ± 0.0083# 0.0133 ± 0.0032#

Give birth to arteries and veins liquid group 0.0601 ± 0.0137 0.0309 ± 0.0102* 0.0162 ± 0.0039*

The low group of SB tablet 0.0656 ± 0.0082 0.0311 ± 0.0097 0.0173 ± 0.0034**

Organize 0.0637 ± 0.0161 0.0321 ± 0.0130*, 0.0175 ± 0.0047** in the SB tablet

The high group of SB tablet 0.0624 ± 0.0129 0.0300 ± 0.0122* 0.0167 ± 0.0041**

The low group of SB mixture 0.0623 ± 0.0156 0.0283 ± 0.0067* 0.0160 ± 0.0039*

Organize 0.0634 ± 0.0115 0.0293 ± 0.0083*, 0.0172 ± 0.0065* in the SB mixture

The high group of SB mixture 0.0539 ± 0.0167 0.0286 ± 0.0067* 0.0143 ± 0.0031

Compare * P＜0.05 * * P＜0.01 with the insufficiency of kidney-YANG model group; Compare with the normal control group

#P＜0.05 ##P＜0.01; Renal aid tablet and mixture be P＞0.05 relatively

Experimental result shows: the insufficiency of kidney-YANG model group loses weight, and spleen, thymus, adrenal gland, testis, seminal vesicle and preputial glands index all reduce, and compares with the normal control group, has significant difference (P＜0.05, P＜0.01).The tablet 7.5g/kg of renal aid place, 15g/kg and 30g/kg dosage group can obviously increase seminal vesicle and preputial glands index, 15g/kg and 30g/kg dosage group can obviously increase thymus index, 30g/kg dosage group can increase adrenal gland's index, relatively has significant difference (P＜0.05 with the insufficiency of kidney-YANG model group, P＜0.01), SHENBAO HEJI 15g/kg and 30g/kg dosage group can obviously increase thymus index, 7.5g/kg, 15g/kg and 30g/kg dosage group can obviously increase seminal vesicle index 7.5g/kg, 15g/kg dosage group can obviously increase the preputial glands index, relatively has significant difference (P＜0.05) renal aid tablet with the insufficiency of kidney-YANG model group and SHENBAO HEJI is not seen bright difference (P＞0.05), prompting: renal aid tablet and SHENBAO HEJI have the effect that prevents body of gland and sexual organ's atrophy, and be comparatively remarkable with the effect of renal aid tablet.

Table 5 renal aid tablet and SHENBAO HEJI are to the influence of castrated rats organ index (g/100g) (X ± S)

Group thymus adrenal gland preputial glands seminal vesicle

Normal control group 0.329 ± 0.031 0.027 ± 0.004 0.042 ± 0.006 0.039 ± 0.013

Castration model group 0.309 ± 0.055 0.023 ± 0.005 0.027 ± 0.006##, 0.016 ± 0.005##

Five-seed Yanzong group 0.345 ± 0.049 0.032 ± 0.009 0.032 ± 0.009 0.021 ± 0.008

Propanoic acid testis group 0.275 ± 0.051 0.025 ± 0.005 0.048 ± 0.014*, 0.039 ± 0.071*

SB sheet low dose group 0.316 ± 0.069 0.029 ± 0.007 0.033 ± 0.007 0.019 ± 0.009

Dosage group 0.338 in the SB sheet ± 0.048 0.027 ± 0.006 0.031 ± 0.007 0.019 ± 0.006

SB sheet high dose group 0.329 ± 0.061 0.025 ± 0.003 0.029 ± 0.007 0.021 ± 0.005

SB closes low dose group 0.328 ± 0.061 0.027 ± 0.005 0.030 ± 0.008 0.019 ± 0.007

SB closes middle dosage group 0.338 ± 0.053 0.028 ± 0.006 0.029 ± 0.005 0.019 ± 0.005

SB closes high dose group 0.333 ± 0.069 0.028 ± 0.004 0.030 ± 0.005 0.019 ± 0.007

Compare * P＜0.05 with the castration model group, compare #P＜0.05 with the normal control group, ##P＜0.01 renal aid tablet and mixture be P＞0.05 relatively

Experimental result shows: after rat testicle was extractd, seminal vesicle and preputial glands index obviously descended, and relatively have significant difference (P＜0.01) with the normal control group, and the prompting castration is performed the operation successfully.Renal aid tablet and SHENBAO HEJI 5g/kg, 10g/kg and 20g/kg are to thymus, adrenal gland, seminal vesicle and preputial glands index have ascendant trend, the load not statistically significant, renal aid tablet and SHENBAO HEJI are not seen notable difference (P＞0.05), and prompting: renal aid tablet and SHENBAO HEJI do not see that to the castrated rats gonad obvious effect is arranged.

Table 6 renal aid tablet and SHENBAO HEJI are to the influence of rat sexual behaviour and testosterone levels (X ± S)

The number of times testosterone is caught in erect incubation period sexual behaviour of group incubation period

In (second) (second) 20 minutes (ng/dl)

Normal control group 12.1 ± 2.51 127.9 ± 82.18 11.9 ± 6.69 108.25 ± 36.77

Castration model group 19.3 ± 4.47## 259.4 ± 69.10## 5.1 ± 1.59## 56.36 ± 13.78##

Five-seed Yanzong group 15.1 ± 3.90* 202.8 ± 91.46 7.4 ± 3.06* 63.68 ± 5.35

Propanoic acid testis group 12.0 ± 4.13** 153.2 ± 84.64** 9.8 ± 4.13** 290.05 ± 111.22**

SB sheet low dose group 14.5 ± 4.79* 213.8 ± 99.12 7.6 ± 2.98*, 69.41 ± 8.65*

Dosage group 14.0 ± 4.49* 178.7 ± 98.54* 7.8 ± 3.45* 71.15 ± 9.46* in the SB sheet

SB sheet high dose group 14.1 ± 3.63** 170.2 ± 73.55** 7.3 ± 2.86* 71.52 ± 8.21*

SB closes low dose group 15.2 ± 4.58 198.0 ± 88.54 6.8 ± 3.01 69.91 ± 8.72

SB closes middle dosage group 14.1 ± 4.46* 194.6 ± 66.95* 7.2 ± 2.78* 65.54 ± 9.24

SB closes high dose group 14.1 ± 4.55* 176.7 ± 105.89* 7.6 ± 3.20* 64.66 ± 4.78

Compare * P＜0.05 with the castration model group, #P＜0.05 is compared with the normal control group in * * P＜0.01, ##P＜0.01, and renal aid tablet and mixture be P＞0.05 relatively

Experimental result shows; After the male Mus castration, electricity irritation is obviously prolonged to the erection time, the sexual behaviour prolongation of latency is caught number of times and is reduced, and testosterone levels descends in the blood, relatively has significance with the normal control group and closes difference, prompting castration modeling success.

Renal aid tablet 5g/kg, 10g/kg and 20g/kg dosage group all can make castrated rats erection shortening incubation period, the sexual behaviour increased frequency, sexual behaviour shortening incubation period, testosterone levels increases in the blood, relatively has significant difference (P＜0.05, P＜0.01) with the castration model group.SHENBAO HEJI 10g/kg and 20g/kg dosage group can make erect incubation period and sexual behaviour shortening incubation period, the sexual behaviour increased frequency, relatively has significant difference (P＜0.05) with the castration model group, 5g/kg dosage group can make that testosterone levels increases in the blood, relatively has significant difference (P＜0.05) with the castration model group, 10g/kg and 20g/kg can make that testosterone levels has the trend of increasing in the blood, but not statistically significant.Renal aid tablet and SHENBAO HEJI are not seen notable difference (P＞0.05), prompting: renal aid tablet and SHENBAO HEJI can increase its irritability to castrated rats sexual behaviour certain promotion, can impel and secrete testosterone in the blood, improve testosterone levels, more than effect renal aid tablet obviously is better than SHENBAO HEJI.

Table 7 renal aid tablet and SHENBAO HEJI are to the influence of mice organ index (X ± S)

Group thymus adrenal gland seminal vesicle preputial glands testis

(g/10g) (g/10g) (g/10g) (g/10g) (g/10g)

Normal control group 0.028 ± 0.007 0.003 ± 0.001 0.035 ± 0.008 0.027 ± 0.004 0.06 ± 0.009

SB tablet I organizes 0.029 ± 0.006 0.003 ± 0.001 0.042 ± 0.008*, 0.033 ± 0.005* 0.06 ± 0.008

SB tablet II organizes 0.027 ± 0.005 0.003 ± 0.001 0.042 ± 0.005*, 0.032 ± 0.004* 0.06 ± 0.003

SB tablet III organizes 0.033 ± 0.011 0.003 ± 0.001 0.045 ± 0.001* 0.029 ± 0.007 0.07 ± 0.021*

SB mixture I group 0.028 ± 0.006 0.003 ± 0.001 0.030 ± 0.009 0.028 ± 0.004 0.07 ± 0.008

SB mixture II organizes 0.028 ± 0.008 0.003 ± 0.001 0.035 ± 0.011*, 0.032 ± 0.005* 0.07 ± 0.013

SB mixture III organizes 0.028 ± 0.007 0.003 ± 0.001 0.043 ± 0.010* 0.030 ± 0.006 0.07 ± 0.010*

Compare * P＜0.05 with the normal control group, renal aid tablet and mixture be P＞0.05 relatively,

Shown in the experimental result: renal aid tablet 7.5g/kg, 15g/kg and 30g/kg dosage group have the effect that promotes seminal vesicle and preputial glands growth, 30g/kg dosage group also can promote the testis growth, relatively have significant difference (P＜0.05) SHENBAO HEJI 15g/kg and 30g/kg dosage group with the normal control group and can promote the testis growth, relatively has significant difference (P＜0.05) with the normal control group, renal aid tablet and SHENBAO HEJI are not seen notable difference (P＞0.05), prompting renal aid tablet and SHENBAO HEJI have the normal young Mus sexual organ of the promotion suppression of growing, and the effect of renal aid tablet obviously is better than SHENBAO HEJI.

Claims (3)

1. the preparation method of a Chinese medicine preparation, this Chinese medicine is made by following Chinese medicine raw materials by weight proportion,

Herba Epimedii 157-630 part Semen Trigonellae 156-626 part Fructus Rosae Laevigatae 157-630 part Radix Rehmanniae Preparata 156-626 part

Fructus Psoraleae 47-190 part Fructus Cnidii 46-186 part Radix Polygoni Multiflori 124-496 part Herba Cistanches 78-314 part

Fructus Lycii 110-440 part Semen Cuscutae 110-440 part Fructus Schisandrae Chinensis 60-240 part Fructus Rubi 55-220 part

Radix Astragali 85-342 part Radix Ginseng Rubra 33-132 part Rhizoma Atractylodis Macrocephalae 23-94 part Rhizoma Dioscoreae 77-308 part

Poria 50-200 part Radix Angelicae Sinensis 78-312 part Rhizoma Chuanxiong 47-188 part Fructus Foeniculi 24-96 part

Semen Plantaginis 27-110 part Radix Glycyrrhizae Preparata 23-94 part

It is characterized in that this preparation method may further comprise the steps:

A. the Herba Epimedii in the side of getting, Radix Ginseng Rubra alcohol reflux concentrate, and be stand-by;

B. get Fructus Cnidii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi coarse powder, vapor distillation extracts volatile oil, and the decocting liquid after distillation device is in addition collected;

C. get all the other ten four Chinese medicine materials such as Fructus Rosae Laevigatae, extracting in water;

The decocting liquid of d.b and c step merges with the decocting liquid of carrying behind the oil, concentrates, and adds ethanol, leave standstill, filter filtrate recycling ethanol, concentrate, add Herba Epimedii, Radix Ginseng Rubra alcohol extract, stir evenly, add ethanol precipitation, reclaim ethanol, concentrate drying, make dry extract, sneak into volatile oil and obtain effective ingredient;

E. make medicament according to a conventional method with this effective ingredient.

2. according to the preparation method of claim 1, wherein medicament described in the step e is a tablet.

3. according to the preparation method of claim 2, it is characterized in that the method for making of making 1000 tablets of tablets is as follows:

Herba Epimedii 315.3g Semen Trigonellae 313.3g Fructus Rosae Laevigatae 315.3g Radix Rehmanniae Preparata 313.3g

Fructus Psoraleae 95.0g Fructus Cnidii 93.3g Radix Polygoni Multiflori Preparata 248.0g Herba Cistanches 157.7g

Fructus Lycii 220.0g Semen Cuscutae 220.0g Fructus Schisandrae Chinensis 120.0g Fructus Rubi 109.7g

Radix Astragali 171.3g Radix Ginseng Rubra 66.7g Rhizoma Atractylodis Macrocephalae 47.3g Rhizoma Dioscoreae 154.3g

Poria 100.0g Radix Angelicae Sinensis 156.0g Rhizoma Chuanxiong 94.3g Fructus Foeniculi 48.0g

Semen Plantaginis 55.0g Radix Glycyrrhizae Preparata 47.3g

More than 22 flavors, get Herba Epimedii, Radix Ginseng Rubra coarse powder with 10 times of amount 50% soak with ethanol 1 hour, reflux, extract, 2 times, each 2 hours, merge extractive liquid,, recovery ethanol is condensed into relative density and is the medicinal liquid of 1.05 (50 ℃), and is stand-by; Get Fructus Cnidii, Fructus Schisandrae Chinensis, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Fructus Foeniculi coarse powder, add 12 times of water gagings and soaked 40 minutes, extract volatile oil, the decocting liquid liquid after distillation device is in addition collected; Get all the other ten four Chinese medicine materials such as Fructus Rosae Laevigatae, add the water of 12 times of amounts, soaked 40 minutes, decocting secondary, each 1 hour; Decocting liquid merges with the decocting liquid of carrying behind the oil; Amalgamation liquid is condensed into the medicinal liquid that relative density is 1.10 (50 ℃), add ethanol and reach 65%, leave standstill more than 12 hours, filter to containing the alcohol amount, filtrate recycling ethanol, being concentrated into relative density is that 1.12 (50 ℃) add Herba Epimedii, the Radix Ginseng Rubra alcohol extract stirs evenly, and adds ethanol and reaches 85% to containing the alcohol amount, precipitation is more than 12 hours, reclaim ethanol, being concentrated into relative density is that 1.05 (50 ℃) are centrifugal, adds 5% soluble dextrins in the filtrate, spray drying, make dry extract, it is an amount of to add micropowder silica gel, 5% hydroxypropyl cellulose mixes, sieve, the system granule, drying is put cold, sneak into volatile oil with micropowder silica gel absorption, 5% hydroxypropyl cellulose, 1.0% magnesium stearate, suppress 1000 in blocks, the bag film-coat, promptly.