CN102430086A - Traditional Chinese medicine composition with function of tonifying qi of kidneys and preparation method thereof - Google Patents
Traditional Chinese medicine composition with function of tonifying qi of kidneys and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of medicines, provides a traditional Chinese medicine composition with the functions of reinforcing the kidneys and supporting yang as well as strengthening the spleen and replenishing qi, and provides a preparation method of the traditional Chinese medicine composition. The composition provided by the invention can be used for tonifying the kidneys and strengthening yang, treating senile body weakness, improving organism immunity, preventing and treating cardiovascular and cerebrovascular diseases as well as other dysfunction diseases caused by cerebral infarction and cerebral ischemia, can also effectively treat acute and chronic nephropathy, and has a good curative effect.
Description
Invention field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of tonifying Qi of the kidney and preparation method thereof.
Background technology
Along with the development of society and the raising of living standards of the people, people's live and work rhythm is obviously accelerated, and the pressure that is born is increasing; Development of modern industry causes severe contamination to environment simultaneously, and is serious to the radiation of human body, and many people so body immunity descend; Occur suffering from a deficiency of the kidney, insufficiency of vital energy and blood etc.; Thereby cause the generation of many diseases, like the body alopecia, have a dizzy spell, disease such as sore waist and aching in the waist and the back, insomnia dysphoria with smothery sensation, and sexual disorder such as impotence and premature ejaculation, prostatosis.
That sell or common in the market treatment is because the chemicals side effect of the medicine of the above-mentioned disease that insufficiency of vital energy and blood causes is bigger, and most Chinese medicine is not very definite like curative effects such as Pilulae Penis et testis cervi, three animal penes pill and various honeybee products, and expensive.In order to solve above-mentioned deficiency, the inventor is through great deal of experimental, selects that to have a Chinese crude drug of tonifying Qi of the kidney combined for use, obtained better curative effect, and this Chinese medicine composition is cheap, has very high social benefit and economic benefit.
Summary of the invention
The object of the invention aims to provide the Chinese medicine composition of a kind of reinforcing the kidney and supporting YANG, invigorating the spleen and benefiting QI; This Chinese medicine composition is used for kidney invigorating and YANG supporting, old asthenia; Human body immunity improving power; The diseases such as other dysfunction that control cardiovascular and cerebrovascular disease and cerebral infarction, cerebral ischemia cause also can be treated the acute and chronic nephropathy effectively, to remedy treatment nephropathy medicine defect of insufficient on the present market.
Another object of the present invention aims to provide a kind of method for preparing of treating the Chinese medicine composition of acute and chronic nephropathy.
Chinese medicine composition of the present invention selects Fructus Psoraleae, Fructus Alpiniae Oxyphyllae, Gecko, Rhizoma Curculiginis and the Radix Astragali to make up, and makes each efficacy of drugs produce synergism these drug regimens, thereby can more effectively tonify Qi of the kidney.Wherein selected Fructus Psoraleae acrid in the mouth warm in nature, hardship, GUIXIN, kidney and spleen channel have the merit of reinforcing the kidney and supporting YANG, warming the spleen improving inspiration by invigorating kidney-QI, and modern medicine thinks that it has the myocardial nutrition property of increasing blood flow, improves body immunity and antidotal effect, so be monarch drug in we; Fructus Alpiniae Oxyphyllae acrid in the mouth warm in nature has the effect of strengthening the spleen stomach, reason vigour and the kidney invigorating void, and Rhizoma Curculiginis acrid in the mouth warm in nature; Have reinforcing the kidney and supporting YANG, the smart strong muscle of benefit and the effect of promoting the circulation of blood repercussive; So Rhizoma Curculiginis and Fructus Alpiniae Oxyphyllae are all ministerial drug, be total to the principal drug assistance reinforcing the kidney and supporting YANG, with the power of timeliness promoting the circulation of blood strengthening the spleen; And Gecko ability tonifying the lung gas, benefiting essence-blood, the Radix Astragali be invigorating QI to consolidate the body surface resistance, diuretic detumescent then, can help monarch-minister drug invigorating QI to consolidate the body surface resistance, the smart detumescence of benefit; So share, all medicines play the effect of tonifying Qi of the kidney altogether.In order to reach optimum curative effect, also can make up in the present composition with Radix Rosae Laevigatae, Herba Epimedii and Rhizoma Dioscoreae.Because of the flat sweet in the mouth, sour and astringent of Radix Rosae Laevigatae property, ability promoting blood circulation and stopping pain; Herba Epimedii acrid in the mouth, sweet, warm in nature, have kidney-replenishing, bone and muscle strengthening, the effect of wind-damp dispelling; Modern medicine thinks that Herba Epimedii has the kidney invigorating effect, can promote sexual function, and can increase immunity and anti-aging effects; Rhizoma Dioscoreae property is put down sweet in the mouth, ability tonifying the spleen and stomach, lung benefiting kidney; A few flavor medicines share, and the effect of reinforcing the kidney and supporting YANG, invigorating the spleen and benefiting QI is stronger.
The consumption of each raw material of the present composition is also groped to sum up to draw through the inventor in a large number, and the each component consumption is for all to have curative effect preferably in the following weight parts scope: 15～40 parts of 20～50 parts of Fructus Psoraleaes, 10～30 parts of Fructus Alpiniae Oxyphyllae, 5～15 parts of Geckos, 15～40 parts of Rhizoma Curculiginises and the Radixs Astragali.
The consumption of each raw material of the present composition all has preferable curative effect in the following weight parts scope: 20～30 parts of 30～40 parts of Fructus Psoraleaes, 15～25 parts of Fructus Alpiniae Oxyphyllae, 8～12 parts of Geckos, 20～30 parts of Rhizoma Curculiginises and the Radixs Astragali.
The consumption of each raw material of the present composition all has better curative effect in the following weight parts scope: 25 parts of 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and the Radixs Astragali.
The inventor gropes to find through test, and the active component for preparing this medicine can also have 10～30 parts of 10～30 parts of Radix Rosae Laevigataes, 15～40 parts of Herba Epimedii and Rhizoma Dioscoreaes, the effect multiplication that the present composition is tonified Qi of the kidney.
The consumption of each raw material of the present composition has best curative effect in the following weight parts scope: 25 parts of 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and 25 parts of the Radixs Astragali, 25 parts of Radix Rosae Laevigataes, 30 parts of Herba Epimedii and Rhizoma Dioscoreaes.
The present composition can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation, comprises injection type, peroral dosage form, percutaneous dosing dosage form, mucosa absorption dosage form.For example can be with above-mentioned each raw material pulverize, mix homogeneously is processed powder and is taken after mixing it with water; Also can be with above-mentioned each raw material decocting together, the condensed water decocting liquid is mixed and made into then; Or Gecko and Fructus Psoraleae handled through alcohol, be mixed and made into after behind other raw material decoctings, concentrating again.But bring into play curative effect better for each raw material that makes this medicine, the present composition can take following method for preparing to obtain.But these can not be used to limit the protection domain of the present composition.
The present invention is method for preparing more preferably, may further comprise the steps:
A, Gecko and Fructus Psoraleae are added an amount of alcohol soaked 24～48 hours, filter, filtrating is reclaimed alcohol;
B, Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis and the Radix Astragali are added suitable quantity of water decoct 1～3 time, be respectively 0.5～3 hour at every turn, collect decocting liquid, filtering residue decocte with water 1～2 time again was respectively 1.5～3 hours at every turn, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds alcohol, stirs, and leaves standstill 24～48 hours, filters, and filtrating is reclaimed alcohol;
D, step C and A gained filtrating is merged, stir, left standstill 24～48 hours, filter, concentrate, drying promptly gets the active component of the present composition;
E, the active component of the step D gained present composition is added suitable proper quantity of medicinal auxiliary material, be prepared into corresponding pharmaceutical preparation.
Preferred, the method for preparing of Chinese medicine composition of the present invention may further comprise the steps:
A, Gecko and Fructus Psoraleae are added an amount of alcohol soaked 24～48 hours, filter, filtrating is reclaimed alcohol;
B, Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added suitable quantity of water decoct 1～3 time, be respectively 0.5～3 hour at every turn, collect decocting liquid, filtering residue decocte with water 1～2 time again was respectively 1.5～3 hours at every turn, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds alcohol, stirs, and leaves standstill 24～48 hours, filters, and filtrating is reclaimed alcohol;
D, Herba Epimedii is added 2～7 times in water amount decocted 0.5～2 hour, collect volatile oil simultaneously, subsequent use, medicinal liquid device is in addition collected;
E, step C and A gained filtrating is merged, stir, left standstill 24～48 hours, filter, with the combining medicine of step D gained, concentrate, add step D gained volatile oil, drying promptly gets the active component of the present composition;
F, the active component of the step e gained present composition is added suitable proper quantity of medicinal auxiliary material, be prepared into corresponding pharmaceutical preparation.
The resulting active component of said method is added various conventional pharmaceutic adjuvant such as disintegrating agent, lubricant, binding agent of corresponding peroral dosage form etc., be prepared into oral drug preparation with the method for Chinese medicinal of routine.Described oral drug preparation is tablet, capsule, drop pill, suck any peroral dosage forms such as agent, granule, pill, oral liquid and powder.
The present composition can be prepared into oral liquid as follows:
A, take by weighing 25 parts of 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and 25 parts of the Radixs Astragali, 25 parts of Radix Rosae Laevigataes, 30 parts of Herba Epimedii and Rhizoma Dioscoreaes, subsequent use;
B, Gecko and Fructus Psoraleae are added 65% soak with ethanol 40 hours of 8 times of amounts, filter filtrate recycling ethanol;
C, the decocting that Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added 10 times of amounts boil 2 times, and 2 hours for the first time, 1 hour for the second time, collect decocting liquid, the decocting that filtering residue adds 8 times of amounts again boiled 3 hours, filtered merging filtrate;
D, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds ethanol and reaches 55～65% to containing the alcohol amount, stirs, and leaves standstill 40 hours, filters filtrate recycling ethanol;
E, the decocting that Herba Epimedii is added 5 times of amounts boiled 1 hour, collected volatile oil simultaneously, and subsequent use, medicinal liquid device is in addition collected;
F, step C and A gained filtrating is merged, stir, left standstill 40 hours, filter, with the combining medicine of step D gained, add step D gained volatile oil again, add Mel adjustment total amount, stir, promptly get oral liquid of the present invention to 1000ml.
The present composition has the effect of reinforcing the kidney and supporting YANG, invigorating the spleen and benefiting QI; Can be used for kidney invigorating and YANG supporting, old asthenia; Human body immunity improving power, the diseases such as other dysfunction that control cardiovascular and cerebrovascular disease and cerebral infarction, cerebral ischemia cause also can be treated the acute and chronic nephropathy effectively.Still adopt the side effect (like degradation under leukopenia, the immune function) that oral liquid of the present invention causes as antitumor drug respectively adjuvant and chronic renal failure medicine tumour hospital and Hunan Province Affiliated Hospital of the academy of traditional Chinese medicine have carried out relevant Clinical Comparison Study in the Hunan Province, existing result of study is reported respectively as follows:
Test Example 1 oral liquid of the present invention is as the clinical observation of antineoplastic adjuvant
One, physical data
90 cases that we observe are the inpatient who makes a definite diagnosis through pathological section, are divided into two treatment groups and matched group, every group of each 30 example.Three groups of personnel are basic together neat at aspects such as occupation, work post and the state of an illness, have comparability.
Treat 1 group of male's 16 example, the oldest 82 years old, minimum 47 years old, 53.9 years old mean age.Women's 14 examples, maximum 75 years old, minimum 36 years old, 48.7 years old mean age.Pulmonary carcinoma 3 examples in male's case, rhinocarcinoma 4 examples, malignant lymphoma 2 examples, intestinal cancer 2 examples, esophageal carcinoma 3 examples, gastric cancer 2 examples; Cervical cancer 4 examples in women's case, breast carcinoma 2 examples, pulmonary carcinoma 3 examples, gastric cancer 4 examples, laryngeal carcinoma 1 example.
Treat 2 groups of male's 13 examples, the oldest 79 years old, minimum 50 years old, 54.8 years old mean age.Women's 17 examples, maximum 77 years old, minimum 32 years old, 48.1 years old mean age.Pulmonary carcinoma 5 examples in male's case, rhinocarcinoma 2 examples, malignant lymphoma 1 example, intestinal cancer 3 examples, esophageal carcinoma 2 examples; Cervical cancer 5 examples in women's case, breast carcinoma 4 examples, pulmonary carcinoma 2 examples, gastric cancer 3 examples, laryngeal carcinoma 3 examples.
Matched group male 15 examples, the oldest 80 years old, minimum 49 years old, 54.3 years old mean age.Women's 15 examples, maximum 77 years old, minimum 35 years old, 47.6 years old mean age.Pulmonary carcinoma 5 examples in male's case, nasopharyngeal carcinoma 2 examples, malignant lymphoma 2 examples, intestinal cancer 6 examples; Cervical cancer 5 examples in women's case, breast carcinoma 3 examples, pulmonary carcinoma 2 examples, gastric cancer 5 examples.
Two, research method
Observe the patient that case all adopts chemicals (hereinafter to be referred as chemotherapy) and radiotherapy (hereinafter to be referred as radiotherapy); When beginning to accept chemotherapy or radiotherapy; Wherein treat and 1 group of every day sooner or later respectively obey oral liquid 1 of the present invention and (form for 25 parts by 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and the Radix Astragali; As follows) 20ml; Treat and 2 groups of every days sooner or later respectively obey oral liquid 2 of the present invention and (form for 25 parts by 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and 25 parts of the Radixs Astragali, 25 parts of Radix Rosae Laevigataes, 30 parts of Herba Epimedii and Rhizoma Dioscoreae; As follows) 20ml, and take leucogen, batyl alcohol, polyactin sheet conventional medicine simultaneously, two months is a course of treatment; Matched group except that not taking oral liquid of the present invention other all with the treatment group.
Observation index: all carry out the detection of immunoglobulin IGG, IGM, IGA before and after the treatment of three groups of cases, all carry out one time leukocyte, the detection of hematochrome weekly.Other PE of three groups of cases, biochemical analysis, make the rounds of the wards and pathography is all undertaken by routine.Three groups of cases are white before treatment, the cytometer number average is no less than 4000/mm
3, hematochrome is all more than 8.5g.
Three, result of study:
Behind the chemotherapy and radiation through a course of treatment, treat in 1 group leukopenia to 4000/mm
3Below 10 people are arranged, rate of descent is 33.3%, treats in 2 groups leukopenia to 4000/mm
3Below 5 people are arranged, rate of descent is 16.7%, drops to 4000/mm in the matched group
3Below 16 people are arranged, rate of descent is 53.3%, P＜0.01.
Effect to hematochrome: treat 8 examples that have that are lower than in 1 group below the 8g, rate of descent is 26.7%, treats 4 examples that have that are lower than in 2 groups below the 8g, and rate of descent is 13.3%, and 14 examples are arranged in the matched group, and rate of descent is 46.6%, P＜0.05.
Influence to immune indexes: three groups are respectively detected 20 examples, and treating 1 group has 7 routine IGG than reduction before treating, and rate of descent is 35.0%, and treating 2 groups has 4 routine IGG to reduce than treatment is preceding, and rate of descent is 20.0%, and matched group has 10 examples, reduces than before treating, and rate of descent is 50.0%.
Detection IGM treats 1 group has 9 examples than the preceding decline of treatment, and rate of descent is 30.0%, and treating 2 groups has 6 examples than the preceding decline of treatment, and rate of descent is 20.0%, and 13 examples are arranged in the matched group, and rate of descent is 43.3%.
Detection IGA treats 1 group has 8 examples than the preceding decline of treatment, and rate of descent is 26.7%, and treating 2 groups has 5 examples than the preceding decline of treatment, and rate of descent is 16.7%, and 12 examples are arranged in the matched group, and rate of descent is 40%.
Four, conclusion
Through bimestrial clinical observation; Oral liquid of the present invention is as a kind of nurishing tonic for building body article; Leukocyte increasing is truly had certain function, and particularly drug combination has tangible curative effect to patient's leukocyte increasing of chemotherapy radiotherapy, and the effect of hematochrome is also had obvious curative effects; Human body immunity improving power is had certain effect, can be used as one of adjuvant therapy medicaments of the side effect that antitumor drug causes.
Test Example 2 present compositions treatment chronic renal failure clinical observation on the therapeutic effect
One, case is selected
Early metaphase chronic renal failure patient 60 examples are Hunan Province Affiliated Hospital of academy of traditional Chinese medicine clinic case, are divided into 1 group of treatment, treatment 2 groups and matched group at random by the prescription on individual diagnosis order, treat 1 group of 20 example; Male's 8 examples, women's 12 examples, 63.8 years old mean age; The cause of disease has chronic nephritis 5 examples; Hypertensive nephropathy 2 examples, diabetic nephropathy 7 examples, gouty nephropathy 6 examples; Treat 2 group of 20 example, male's 11 examples, women's 9 examples, 65.2 years old mean age, the cause of disease has chronic nephritis 7 examples, hypertensive nephropathy 1 example, diabetic nephropathy 5 examples, gouty nephropathy 7 examples; Matched group 20 examples, male's 10 examples, women's 10 examples, 67.5 years old mean age, the cause of disease has chronic nephritis 5 examples, hypertensive nephropathy 4 examples, diabetic nephropathy 4 examples, gouty nephropathy 7 examples.
Relatively, Bun, Scr no significant difference have comparability (P>0.05) before treatment group and the treatment of control group.
Two, Therapeutic Method
The treatment group is identical with matched group patient's general treatment method, dispels the reversible factors such as the control infection that cause renal function to go down, and controlling blood pressure, blood glucose are corrected gout etc.
Two treatment groups are under above-mentioned general treatment situation; Adding granule 1 of the present invention respectively (is made up of for 25 parts 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and the Radix Astragali; As follows) and granule of the present invention 2 (form for 25 parts by 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and 25 parts of the Radixs Astragali, 25 parts of Radix Rosae Laevigataes, 30 parts of Herba Epimedii and Rhizoma Dioscoreae; As follows), every day 3 times, each 1 bag (5g).
Matched group adds Coated Aldehyde Oxystarch under above-mentioned general treatment situation, every day 3 times, each 1 bag (5 gram).
Two groups was a course of treatment with two months all, judged curative effect in treatment after two months.
Three, statistical method
Each indicator-specific statistics method all adopts pairing measurement data t check before and after the treatment; Relatively adopt single factor variance between each group.Data are represented with mean and standard deviation, add up with the spss software kit.
Four, curative effect determinate standard
Produce effects: treatment back glomerular filtration rate increases >=20%, and serum creatinine descends >=20%;
Effectively: glomerular filtration rate increases >=10%, and serum creatinine descends >=10%;
Invalid: < 10%, serum creatinine does not have decline in the glomerular filtration rate increase.
Five, result
Through clinical statistics, in this test the treatment 1 group in produce effects 5 examples, effective 10 examples, invalid 5 examples; Total effective rate is 75%; Treat produce effects 8 examples in 2 groups, effective 9 examples, invalid 3 examples; Total effective rate is 85%; Produce effects 3 examples in the matched group, effective 8 examples, invalid 9 examples; Total effective rate is 55%.
1, respectively organize Bun before and after the patient treatment, Scr changes relatively, see for details table 1 (with ratio before the treatment, P 0.05 with treatment of control group before and after difference compare, P 0.05)
Bun, Scr change relatively before and after the table 1 liang group patient treatment
2, granule of the present invention influences patient's urine protein qualitatively, sees table 2 for details
Table 2 the present invention influences patient's urine protein qualitatively
In sum; Chinese medicine composition of the present invention not only has tangible reduction effect to serum creatinine, urine protein, and can improve glomerular filtration rate in the treatment of kidney disease process that above-mentioned a variety of causes causes; Renal insufficiency is all had significant curative effect, particularly chronic renal failure better curative effect is arranged.
The specific embodiment
The preparation of embodiment 1, medicinal granule of the present invention
Take by weighing Fructus Psoraleae 700g, Fructus Alpiniae Oxyphyllae 400g, Gecko 200g, Rhizoma Curculiginis 500g and Radix Astragali 500g respectively, be prepared into granule as follows:
A, Gecko and Fructus Psoraleae are added 60% soak with ethanol 24 hours of 8 times of amounts, filter filtrate recycling ethanol;
B, the decocting that Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis and the Radix Astragali are added 10 times of amounts boil 3 times, are respectively 1 hour at every turn, collect decocting liquid, and filtering residue decocte with water 2 times again was respectively 1.5 hours at every turn, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds ethanol and makes and contain the alcohol amount and reach 65%, stirs, and leaves standstill 48 hours, filters filtrate recycling ethanol;
D, step C and A gained filtrating is merged, stir, left standstill 48 hours, filter, concentrate, drying promptly gets the active component of the present composition;
E, the active component of the step D gained present composition is added suitable an amount of granule pharmaceutic adjuvant, be prepared into granule 1000 bags.
The preparation of embodiment 2, medicinal granule of the present invention
Take by weighing Fructus Psoraleae 700g, Fructus Alpiniae Oxyphyllae 400g, Gecko 200g, Rhizoma Curculiginis 500g, Radix Astragali 500g, Radix Rosae Laevigatae 500g, Herba Epimedii 600g and Rhizoma Dioscoreae 500g respectively, be prepared into granule as follows:
A, Gecko and Fructus Psoraleae are added the soak with ethanol 40 hours of 5 times of amounts 70%, filter filtrate recycling ethanol;
B, Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added suitable quantity of water decoct 2 times, the decocting that adds 8 times of amounts for the first time boiled 1 hour, and the decocting that adds 10 times of amounts for the second time boiled 2 hours, collected decocting liquid, filtered merging filtrate; Filtering residue decocte with water again decocted 3 hours for 1 time, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds ethanol and makes and contain the alcohol amount and reach 60%, stirs, and leaves standstill 48 hours, filters filtrate recycling ethanol;
D, Herba Epimedii is added 5 times in water amount decocted 2 hours, it is subsequent use to collect volatile oil simultaneously, and medicinal liquid device is in addition collected;
E, step C and A gained filtrating is merged, stir, left standstill 40 hours, filter, with the combining medicine of step D gained, concentrate, add step D gained volatile oil, drying promptly gets the active component of the present composition;
F, the active component of the step e gained present composition is added the pharmaceutic adjuvant of suitable an amount of granule, be prepared into granule 1000 bags.
The preparation of embodiment 3, medicine oral liquid of the present invention
Take by weighing Fructus Psoraleae 750g, Fructus Alpiniae Oxyphyllae 150g, Gecko 75g, Rhizoma Curculiginis 600g and Radix Astragali 300g respectively, be prepared into oral liquid as follows:
A, Gecko and Fructus Psoraleae are added the soak with ethanol 48 hours of 10 times of amounts 75%, filter filtrate recycling ethanol;
B, the decocting that Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added 8 times of amounts boiled 3 hours, and the decocting that filtering residue adds 6 times of amounts again boils 2 times, each 3 hours, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds ethanol and makes and contain the alcohol amount and reach 65%, stirs, and leaves standstill 24 hours, filters filtrate recycling ethanol;
D, Herba Epimedii is added 8 times in water amount decocted 1 hour, it is subsequent use to collect volatile oil simultaneously, and medicinal liquid device is in addition collected;
E, step C and A gained filtrating is merged, stir, left standstill 48 hours, filter, with the combining medicine of step D gained, concentrate again, add step D gained volatile oil, add the pharmaceutic adjuvant of suitable an amount of oral liquid, be prepared into oral liquid 1000ml.
The preparation of embodiment 4, medicine oral liquid of the present invention
Take by weighing Fructus Psoraleae 500g, Fructus Alpiniae Oxyphyllae 750g, Gecko 125g, Rhizoma Curculiginis 375g, Radix Astragali 375g, Radix Rosae Laevigatae 750g, Herba Epimedii 375g and Rhizoma Dioscoreae 250g respectively, be prepared into oral liquid as follows:
A, Gecko and Fructus Psoraleae are added 65% soak with ethanol 40 hours of 8 times of amounts, filter filtrate recycling ethanol;
C, the decocting that Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added 10 times of amounts boil 2 times, and 2 hours for the first time, 1 hour for the second time, collect decocting liquid, the decocting that filtering residue adds 8 times of amounts again boiled 3 hours, filtered merging filtrate;
D, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds ethanol and reaches 55～65% to containing the alcohol amount, stirs, and leaves standstill 40 hours, filters filtrate recycling ethanol;
E, the decocting that Herba Epimedii is added 5 times of amounts boiled 1 hour, collected volatile oil simultaneously, and subsequent use, medicinal liquid device is in addition collected;
F, step C and A gained filtrating is merged, stir, left standstill 40 hours, filter, with the combining medicine of step D gained, add step D gained volatile oil again, add Mel adjustment total amount, stir, promptly get oral liquid of the present invention to 1000ml.
The preparation of embodiment 5, drug powder of the present invention
Take by weighing Fructus Psoraleae 300g, Fructus Alpiniae Oxyphyllae 200g, Gecko 100g, Rhizoma Curculiginis 250g, Radix Astragali 250g, Radix Rosae Laevigatae 200g, Herba Epimedii 250g and Rhizoma Dioscoreae 200g respectively, each flavor medical material pulverize separately is become fine powder, mix homogeneously promptly gets powder 1000 bags of the present invention.
The preparation of embodiment 6, medicine capsule of the present invention
Take by weighing Fructus Psoraleae 450g, Fructus Alpiniae Oxyphyllae 225g, Gecko 120g, Rhizoma Curculiginis 300g, Radix Astragali 300g, Radix Rosae Laevigatae 150g, Herba Epimedii 225g and Rhizoma Dioscoreae 150g respectively; Each flavor medical material pulverize separately is become coarse powder, mix homogeneously, the decocting that adds 5 times of amounts boiled 2 hours; Filter; Filtrating concentrates, and drying under reduced pressure adds suitable an amount of capsule adjuvant and gets 1000 of capsules of the present invention.
Claims (10)
1. Chinese medicine composition of tonifying Qi of the kidney, the parts by weight of raw materials that it is characterized in that preparing the main active of this medicine is: 15～40 parts of 20～50 parts of Fructus Psoraleaes, 10～30 parts of Fructus Alpiniae Oxyphyllae, 5～15 parts of Geckos, 15～40 parts of Rhizoma Curculiginises and the Radixs Astragali.
2. Chinese medicine composition according to claim 1, the parts by weight of raw materials that it is characterized in that preparing the main active of this medicine is: 20～30 parts of 30～40 parts of Fructus Psoraleaes, 15～25 parts of Fructus Alpiniae Oxyphyllae, 8～12 parts of Geckos, 20～30 parts of Rhizoma Curculiginises and the Radixs Astragali.
3. Chinese medicine composition according to claim 1, the parts by weight of raw materials that it is characterized in that preparing the main active of this medicine is: 25 parts of 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and the Radixs Astragali.
4. the method for preparing of each described Chinese medicine composition of claim 1 to 3, it may further comprise the steps:
A, Gecko and Fructus Psoraleae are added an amount of alcohol soaked 24～48 hours, filter, filtrating is reclaimed alcohol;
B, Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis and the Radix Astragali are added suitable quantity of water decoct 1～3 time, be respectively 0.5～3 hour at every turn, collect decocting liquid, filtering residue decocte with water 1～2 time again was respectively 1.5～3 hours at every turn, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds alcohol, stirs, and leaves standstill 24～48 hours, filters, and filtrating is reclaimed alcohol;
D, step C and A gained filtrating is merged, stir, left standstill 24～48 hours, filter, concentrate, drying promptly gets the active component of the present composition;
E, the active component of the step D gained present composition is added suitable proper quantity of medicinal auxiliary material, be prepared into corresponding pharmaceutical preparation.
5. Chinese medicine composition according to claim 1, wherein crude drug can also have 10～30 parts of 10～30 parts of Radix Rosae Laevigataes, 15～40 parts of Herba Epimedii and Rhizoma Dioscoreaes.
6. Chinese medicine composition according to claim 1, the weight portion of raw material that it is characterized in that preparing the main active of this medicine is: 25 parts of 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and 25 parts of the Radixs Astragali, 25 parts of Radix Rosae Laevigataes, 30 parts of Herba Epimedii and Rhizoma Dioscoreaes.
7. according to the method for preparing of claim 5 or 6 said Chinese medicine compositions, it may further comprise the steps:
A, Gecko and Fructus Psoraleae are added an amount of alcohol soaked 24～48 hours, filter, filtrating is reclaimed alcohol;
B, Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added suitable quantity of water decoct 1～3 time, be respectively 0.5～3 hour at every turn, collect decocting liquid, filtering residue decocte with water 1～2 time again was respectively 1.5～3 hours at every turn, filtered merging filtrate;
C, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds alcohol, stirs, and leaves standstill 24～48 hours, filters, and filtrating is reclaimed alcohol;
D, Herba Epimedii is added 2～7 times in water amount decocted 0.5～2 hour, collect volatile oil simultaneously, subsequent use, medicinal liquid device is in addition collected;
E, step C and A gained filtrating is merged, stir, left standstill 24～48 hours, filter, with the combining medicine of step D gained, concentrate, add step D gained volatile oil, drying promptly gets the active component of the present composition;
F, the active component of the step e gained present composition is added suitable proper quantity of medicinal auxiliary material, be prepared into corresponding pharmaceutical preparation.
8. according to each described Chinese medicine composition of claim 1～7; Said composition is to be prepared into any pharmaceutical preparation that allows on the pharmaceutics by described main active and pharmacy acceptable adjuvant, can process peroral dosage form, injection type and transdermal dosage form.
9. Chinese medicine composition according to claim 8 is characterized in that the pharmaceutical preparation that said Chinese medicine composition is processed is oral liquid.
10. the method for preparing of the said oral liquid of the present invention of claim 9, it may further comprise the steps:
A, take by weighing 25 parts of 35 parts of Fructus Psoraleaes, 20 parts of Fructus Alpiniae Oxyphyllae, 10 parts of Geckos, 25 parts of Rhizoma Curculiginises and 25 parts of the Radixs Astragali, 25 parts of Radix Rosae Laevigataes, 30 parts of Herba Epimedii and Rhizoma Dioscoreaes, subsequent use;
B, Gecko and Fructus Psoraleae are added 65% soak with ethanol 40 hours of 8 times of amounts, filter filtrate recycling ethanol;
C, the decocting that Fructus Alpiniae Oxyphyllae, Rhizoma Curculiginis, the Radix Astragali, Radix Rosae Laevigatae and Rhizoma Dioscoreae are added 10 times of amounts boil 2 times, and 2 hours for the first time, 1 hour for the second time, collect decocting liquid, the decocting that filtering residue adds 8 times of amounts again boiled 3 hours, filtered merging filtrate;
D, step B gained filtrating is condensed into density is 1.12～1.28 clear paste, adds ethanol and reaches 55～65% to containing the alcohol amount, stirs, and leaves standstill 40 hours, filters filtrate recycling ethanol;
E, the decocting that Herba Epimedii is added 5 times of amounts boiled 1 hour, collected volatile oil simultaneously, and subsequent use, medicinal liquid device is in addition collected;
F, step C and A gained filtrating is merged, stir, left standstill 40 hours, filter, with the combining medicine of step D gained, add step D gained volatile oil again, add Mel adjustment total amount, stir, promptly get oral liquid of the present invention to 1000ml.
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Cited By (1)
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| CN103083434A (en) * | 2013-02-22 | 2013-05-08 | 上海市普陀区中心医院 | Yang warming and blood activating traditional Chinese compound preparation for preventing and treating chronic kidney diseases and application thereof |
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Application publication date: 20120502 |